| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P0CF34 | 1048 | YL017_YEAST Putative guanine nucleotide excha... | 409 | 1e-35 | 147 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 2 | Q02342 | 1095 | CDC25_LACKL Cell division control protein 25 ... | 432 | 3e-34 | 143 | 29 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 3 | B5VMS9 | 1265 | SDC25_YEAS6 Guanine nucleotide exchange facto... | 98 | 2.6 | 35 | 21 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 4 | B3LTF3 | 1252 | SDC25_YEAS1 Guanine nucleotide exchange facto... | 93 | 2.6 | 35 | 22 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 5 | A7A0P0 | 1252 | SDC25_YEAS7 Guanine nucleotide exchange facto... | 93 | 2.8 | 35 | 22 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 6 | P0CF32 | 1253 | SDC25_YEASX Guanine nucleotide exchange facto... | 409 | 7e-34 | 142 | 26 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 7 | C8ZCV7 | 1252 | SDC25_YEAS8 Guanine nucleotide exchange facto... | 93 | 2.5 | 35 | 22 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 8 | P43069 | 1333 | CDC25_CANAL Cell division control protein 25 ... | 71 | 0.16 | 38.9 | 25 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:CGD. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; IMP:CGD.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0071333; P:cellular response to glucose stimulus; IMP:CGD.::GO:0030447; P:filamentous growth; IMP:CGD.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IGI:CGD.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 9 | P04821 | 1589 | CDC25_YEAST Cell division control protein 25 ... | 64 | 0.94 | 36.6 | 30 | 47 | GO:0005829; C:cytosol; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:SGD. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IMP:SGD.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0001302; P:replicative cell aging; IMP:SGD.::GO:0007089; P:traversing start control point of mitotic cell cycle; IMP:SGD. | 10 | B0M0P8 | 2356 | GEFL_DICDI Ras guanine nucleotide exchange fa... | 391 | 1e-27 | 123 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0003779; F:actin binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017048; F:Rho GTPase binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.::GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase.::GO:0043052; P:thermotaxis; IMP:dictyBase. | 11 | Q02384 | 1333 | SOS2_MOUSE Son of sevenless homolog 2 OS=Mus ... | 388 | 1e-26 | 120 | 23 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI. | 12 | Q07890 | 1332 | SOS2_HUMAN Son of sevenless homolog 2 OS=Homo... | 387 | 2e-26 | 119 | 24 | 47 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB. | 13 | Q07889 | 1333 | SOS1_HUMAN Son of sevenless homolog 1 OS=Homo... | 395 | 2e-25 | 116 | 24 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005100; F:Rho GTPase activator activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome. | 14 | Q62245 | 1319 | SOS1_MOUSE Son of sevenless homolog 1 OS=Mus ... | 395 | 2e-25 | 115 | 24 | 47 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI. | 15 | Q9USU1 | 987 | EFC25_SCHPO Ras guanine nucleotide exchange f... | 402 | 6e-24 | 111 | 24 | 45 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IMP:PomBase. | | | | | | | | | | GO:0032488; P:Cdc42 protein signal transduction; TAS:PomBase.::GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.::GO:0007163; P:establishment or maintenance of cell polarity; IGI:PomBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 16 | Q54PQ4 | 605 | GEFA_DICDI Ras guanine nucleotide exchange fa... | 379 | 1e-22 | 106 | 23 | 44 | GO:0005829; C:cytosol; IDA:dictyBase. | | | | | | | | | | GO:0030250; F:guanylate cyclase activator activity; IMP:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007190; P:activation of adenylate cyclase activity; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 17 | Q54TK8 | 1502 | GEFP_DICDI Ras guanine nucleotide exchange fa... | 403 | 2e-21 | 103 | 24 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 18 | Q8IS15 | 824 | GEFI_DICDI Ras guanine nucleotide exchange fa... | 369 | 8e-21 | 101 | 23 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 19 | Q8IS14 | 812 | GEFJ_DICDI Ras guanine nucleotide exchange fa... | 395 | 1e-20 | 100 | 24 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 20 | Q8SSQ3 | 929 | GEFM_DICDI Ras guanine nucleotide exchange fa... | 154 | 1.2 | 36.2 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:dictyBase.::GO:0050850; P:positive regulation of calcium-mediated signaling; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 21 | Q552M5 | 1508 | GEFY_DICDI Ras guanine nucleotide exchange fa... | 199 | 6e-20 | 98.6 | 31 | 52 | GO:0005813; C:centrosome; IDA:dictyBase. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 22 | P26674 | 911 | STE6_SCHPO Protein ste6 OS=Schizosaccharomyce... | 392 | 1e-19 | 97.1 | 23 | 47 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000747; P:conjugation with cellular fusion; IMP:PomBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 23 | P26675 | 1596 | SOS_DROME Protein son of sevenless OS=Drosoph... | 402 | 5e-18 | 92.8 | 23 | 42 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0008595; P:anterior/posterior axis specification, embryo; TAS:FlyBase.::GO:0045749; P:negative regulation of S phase of mitotic cell cycle; IMP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0045500; P:sevenless signaling pathway; TAS:FlyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0008293; P:torso signaling pathway; TAS:FlyBase.::GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase. | 24 | Q9NZL6 | 768 | RGL1_HUMAN Ral guanine nucleotide dissociatio... | 427 | 2e-17 | 90.5 | 24 | 42 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 25 | Q8IS18 | 1037 | GEFE_DICDI Ras guanine nucleotide exchange fa... | 48 | 1.5 | 35.8 | 33 | 60 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0043052; P:thermotaxis; IMP:dictyBase. | 26 | Q8ST25 | 1556 | GEFG_DICDI Ras guanine nucleotide exchange fa... | 404 | 3e-17 | 90.1 | 23 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 27 | Q55GH9 | 1172 | GEFW_DICDI Ras guanine nucleotide exchange fa... | 412 | 3e-17 | 90.1 | 21 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 28 | Q13905 | 1077 | RPGF1_HUMAN Rap guanine nucleotide exchange f... | 378 | 3e-17 | 90.1 | 25 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; TAS:Reactome. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 29 | B0UXH6 | 581 | RGPS1_DANRE Ras-specific guanine nucleotide-r... | 185 | 4e-17 | 89 | 28 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 30 | Q60695 | 768 | RGL1_MOUSE Ral guanine nucleotide dissociatio... | 427 | 1e-16 | 87.8 | 24 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 31 | Q86G47 | 1298 | GEFQ_DICDI Ras guanine nucleotide exchange fa... | 238 | 1e-16 | 87.8 | 28 | 47 | GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0005829; C:cytosol; IDA:dictyBase. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0045159; F:myosin II binding; IPI:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0043520; P:regulation of myosin II filament assembly; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. |
