| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q32N25 | 594 | GRP2A_XENLA RAS guanyl-releasing protein 2-A ... | 295 | 0.0000000000004 | 75.9 | 25 | 46 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 62 | A4IFE4 | 472 | RGF1B_BOVIN Ras-GEF domain-containing family ... | 385 | 0.0000000000005 | 75.5 | 24 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 63 | Q5TJE5 | 780 | RGL2_CANFA Ral guanine nucleotide dissociatio... | 404 | 0.0000000000005 | 75.9 | 24 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 64 | Q9Y4G8 | 1499 | RPGF2_HUMAN Rap guanine nucleotide exchange f... | 187 | 0.0000000000006 | 76.3 | 30 | 48 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0005622; C:intracellular; TAS:GOC. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; NAS:UniProtKB.::GO:0000165; P:MAPK cascade; NAS:UniProtKB.::GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:UniProtKB. | 65 | F1M386 | 1496 | RPGF2_RAT Rap guanine nucleotide exchange fac... | 185 | 0.0000000000006 | 76.3 | 30 | 49 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 66 | Q8CHG7 | 1496 | RPGF2_MOUSE Rap guanine nucleotide exchange f... | 185 | 0.0000000000006 | 76.3 | 30 | 49 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 67 | Q3UYI5 | 709 | RGL3_MOUSE Ral guanine nucleotide dissociatio... | 224 | 0.0000000000009 | 75.1 | 25 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; IDA:MGI.::GO:0017016; F:Ras GTPase binding; IDA:MGI. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:MGI. | 68 | Q03385 | 852 | GNDS_MOUSE Ral guanine nucleotide dissociatio... | 244 | 0.000000000001 | 75.1 | 25 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 69 | Q03386 | 895 | GNDS_RAT Ral guanine nucleotide dissociation ... | 144 | 0.57 | 37.4 | 23 | 44 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; TAS:RGD. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:RGD. | 70 | Q8IV61 | 690 | GRP3_HUMAN Ras guanyl-releasing protein 3 OS=... | 221 | 0.000000000004 | 73.2 | 26 | 48 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB. | | | | | | | | | | GO:0000165; P:MAPK cascade; NAS:UniProtKB. | 71 | Q54FF3 | 1557 | GEFK_DICDI Ras guanine nucleotide exchange fa... | 244 | 0.000000000004 | 73.6 | 27 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 72 | Q8IZJ4 | 473 | RGDSR_HUMAN Ral-GDS-related protein OS=Homo s... | 155 | 0.000000000005 | 72.4 | 30 | 52 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 73 | Q8IS21 | 1529 | GEFB_DICDI Ras guanine nucleotide exchange fa... | 405 | 0.000000000005 | 73.2 | 20 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IGI:dictyBase. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0030866; P:cortical actin cytoskeleton organization; IMP:dictyBase.::GO:0051271; P:negative regulation of cellular component movement; IMP:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:dictyBase.::GO:0050766; P:positive regulation of phagocytosis; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0019953; P:sexual reproduction; IEP:dictyBase. | 74 | Q3MIN7 | 710 | RGL3_HUMAN Ral guanine nucleotide dissociatio... | 410 | 0.000000000006 | 72.8 | 22 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 75 | Q6DCK3 | 594 | GRP2B_XENLA RAS guanyl-releasing protein 2-B ... | 295 | 0.000000000008 | 72 | 25 | 46 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 76 | Q8IS20 | 1457 | GEFC_DICDI Ras guanine nucleotide exchange fa... | 126 | 0.00001 | 52.8 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 77 | O95267 | 797 | GRP1_HUMAN RAS guanyl-releasing protein 1 OS=... | 217 | 0.00000000006 | 69.3 | 27 | 48 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; TAS:ProtInc.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome.::GO:0008289; F:lipid binding; TAS:ProtInc. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 78 | Q12967 | 914 | GNDS_HUMAN Ral guanine nucleotide dissociatio... | 244 | 0.0000000001 | 68.9 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IDA:UniProtKB. | | | | | | | | | | GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 79 | Q1LZ97 | 673 | GRP4_BOVIN RAS guanyl-releasing protein 4 OS=... | 310 | 0.0000000002 | 67.4 | 24 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0016049; P:cell growth; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0009991; P:response to extracellular stimulus; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 80 | P0C643 | 608 | GRP2_RAT RAS guanyl-releasing protein 2 OS=Ra... | 167 | 0.0000000003 | 67 | 29 | 47 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 81 | Q7LDG7 | 609 | GRP2_HUMAN RAS guanyl-releasing protein 2 OS=... | 167 | 0.0000000003 | 67 | 29 | 47 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 82 | Q8C0Q9 | 814 | RPGF5_MOUSE Rap guanine nucleotide exchange f... | 209 | 0.0000000003 | 67 | 25 | 45 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0030742; F:GTP-dependent protein binding; ISS:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 83 | Q9Z1S3 | 795 | GRP1_MOUSE RAS guanyl-releasing protein 1 OS=... | 217 | 0.0000000004 | 66.6 | 27 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 84 | P83900 | 580 | RPGF5_RAT Rap guanine nucleotide exchange fac... | 209 | 0.0000000004 | 66.2 | 25 | 45 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 85 | Q9R1K8 | 795 | GRP1_RAT RAS guanyl-releasing protein 1 OS=Ra... | 216 | 0.0000000005 | 66.6 | 27 | 47 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; TAS:RGD. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 86 | Q9QUG9 | 608 | GRP2_MOUSE RAS guanyl-releasing protein 2 OS=... | 167 | 0.0000000006 | 65.9 | 29 | 47 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 87 | A0JM95 | 475 | RGF1A_XENTR Ras-GEF domain-containing family ... | 414 | 0.0000000006 | 65.5 | 21 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 88 | Q92565 | 580 | RPGF5_HUMAN Rap guanine nucleotide exchange f... | 199 | 0.0000000008 | 65.5 | 25 | 45 | GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0030742; F:GTP-dependent protein binding; IPI:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:0007399; P:nervous system development; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB. | 89 | Q8N431 | 466 | RGF1C_HUMAN Ras-GEF domain-containing family ... | 371 | 0.000000003 | 63.5 | 22 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 90 | Q6NTL4 | 791 | GRP1_XENLA RAS guanyl-releasing protein 1 OS=... | 216 | 0.000000004 | 63.5 | 25 | 46 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 91 | Q6DBW1 | 475 | RG1BB_DANRE Ras-GEF domain-containing family ... | 378 | 0.000000005 | 62.8 | 20 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
