rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
121 | Q54J14 | 928 | GXCH_DICDI RhoGEF domain-containing protein g... | 174 | 1.3 | 36.2 | 24 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 122 | Q08DN7 | 844 | VAV_BOVIN Proto-oncogene vav OS=Bos taurus (B... | 182 | 1.3 | 36.2 | 21 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 123 | Q6ZPF3 | 1715 | TIAM2_MOUSE T-lymphoma invasion and metastasi... | 188 | 1.6 | 36.2 | 22 | 43 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:MGI. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 124 | A1L390 | 1219 | PKHG3_HUMAN Pleckstrin homology domain-contai... | 177 | 2 | 35.8 | 25 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 125 | Q5VV41 | 709 | ARHGG_HUMAN Rho guanine nucleotide exchange f... | 244 | 2.1 | 35.4 | 23 | 40 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:0032864; P:activation of Cdc42 GTPase activity; IDA:BHF-UCL.::GO:0032863; P:activation of Rac GTPase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0060326; P:cell chemotaxis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 126 | Q9Y4F1 | 1045 | FARP1_HUMAN FERM, RhoGEF and pleckstrin domai... | 168 | 2.1 | 35.8 | 24 | 42 | GO:0005737; C:cytoplasm; IEA:InterPro.::GO:0005856; C:cytoskeleton; TAS:ProtInc.::GO:0019898; C:extrinsic to membrane; IEA:InterPro. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 127 | Q4VAC9 | 1341 | PKHG3_MOUSE Pleckstrin homology domain-contai... | 177 | 2.2 | 35.8 | 26 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 128 | O94989 | 841 | ARHGF_HUMAN Rho guanine nucleotide exchange f... | 196 | 2.5 | 35.4 | 21 | 40 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0030425; C:dendrite; ISS:UniProtKB. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:2000297; P:negative regulation of synapse maturation; ISS:UniProtKB.::GO:0051496; P:positive regulation of stress fiber assembly; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 129 | A2AAJ9 | 8891 | OBSCN_MOUSE Obscurin OS=Mus musculus (Mouse).... | 95 | 2.6 | 35.4 | 26 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 130 | Q8IVF5 | 1701 | TIAM2_HUMAN T-lymphoma invasion and metastasi... | 188 | 2.9 | 35.4 | 22 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 131 | Q8BW86 | 850 | ARG33_MOUSE Rho guanine nucleotide exchange f... | 198 | 3.1 | 35 | 28 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 132 | A8MVX0 | 844 | ARG33_HUMAN Rho guanine nucleotide exchange f... | 198 | 3.1 | 35 | 27 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 133 | Q86VW2 | 580 | ARHGP_HUMAN Rho guanine nucleotide exchange f... | 193 | 3.3 | 35 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 134 | A6WKS2 | 554 | HCP_SHEB8 Hydroxylamine reductase OS=Shewanel... | 77 | 3.7 | 34.7 | 34 | 53 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016661; F:oxidoreductase activity, acting on other nitrogenous compounds as donors; IEA:InterPro. | | | | | | | | | | | 135 | A9L5Q1 | 554 | HCP_SHEB9 Hydroxylamine reductase OS=Shewanel... | 77 | 4.1 | 34.7 | 34 | 53 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016661; F:oxidoreductase activity, acting on other nitrogenous compounds as donors; IEA:InterPro. | | | | | | | | | | | 136 | A1IGU5 | 675 | ARH37_HUMAN Rho guanine nucleotide exchange f... | 146 | 6.2 | 33.9 | 26 | 45 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 137 | Q91VS8 | 1065 | FARP2_MOUSE FERM, RhoGEF and pleckstrin domai... | 205 | 6.6 | 34.3 | 25 | 41 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0019898; C:extrinsic to membrane; IEA:InterPro. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 138 | P40995 | 872 | SCD1_SCHPO Rho guanine nucleotide exchange fa... | 195 | 6.8 | 33.9 | 23 | 44 | GO:0071521; C:Cdc42 GTPase complex; TAS:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0043332; C:mating projection tip; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0005819; C:spindle; IDA:PomBase. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:PomBase. | | | | | | | | | | GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0032488; P:Cdc42 protein signal transduction; IC:PomBase.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0032955; P:regulation of barrier septum assembly; IGI:PomBase.::GO:0043088; P:regulation of Cdc42 GTPase activity; TAS:PomBase.::GO:0008360; P:regulation of cell shape; IMP:PomBase.::GO:0030100; P:regulation of endocytosis; IMP:PomBase.::GO:0032878; P:regulation of establishment or maintenance of cell polarity; IMP:PomBase.::GO:0032887; P:regulation of spindle elongation; IMP:PomBase.::GO:0032005; P:signal transduction involved in conjugation with cellular fusion; IMP:PomBase. | 139 | Q8DZQ2 | 233 | PYRF_STRA5 Orotidine 5'-phosphate decarboxyla... | 190 | 7.3 | 33.1 | 23 | 41 | | | | | | | | | | | GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC. | | | | | | | | | | GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro. | 140 | Q03F66 | 690 | SYGB_PEDPA Glycine--tRNA ligase beta subunit ... | 38 | 8.1 | 33.9 | 39 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004814; F:arginine-tRNA ligase activity; IEA:InterPro.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004820; F:glycine-tRNA ligase activity; IEA:EC. | | | | | | | | | | GO:0006420; P:arginyl-tRNA aminoacylation; IEA:InterPro.::GO:0006426; P:glycyl-tRNA aminoacylation; IEA:InterPro. |