| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | O13359 | 938 | KEX2_CANAW Kexin OS=Candida albicans (strain ... | 669 | 6e-163 | 506 | 41 | 59 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 2 | P09231 | 756 | KEX1A_KLULA Protease KEX1 OS=1267 / NRRL Y-11... | 550 | 7e-161 | 496 | 45 | 63 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 3 | Q09175 | 709 | KRP1_SCHPO Dibasic-processing endoprotease OS... | 708 | 2e-153 | 474 | 39 | 55 | GO:0009986; C:cell surface; NAS:PomBase.::GO:0005794; C:Golgi apparatus; IDA:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IDA:PomBase. | | | | | | | | | | GO:0071432; P:peptide mating pheromone maturation involved in conjugation with cellular fusion; TAS:PomBase.::GO:0016485; P:protein processing; ISS:RefGenome.::GO:0006508; P:proteolysis; IGI:PomBase. | 4 | P13134 | 814 | KEX2_YEAST Kexin OS=Saccharomyces cerevisiae ... | 562 | 1e-152 | 476 | 44 | 62 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005802; C:trans-Golgi network; IDA:SGD. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IDA:SGD. | | | | | | | | | | GO:0007323; P:peptide pheromone maturation; IMP:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 5 | P42781 | 976 | XPR6_YARLI Dibasic-processing endoprotease OS... | 635 | 3e-139 | 445 | 40 | 56 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 6 | P28840 | 752 | NEC1_RAT Neuroendocrine convertase 1 OS=Rattu... | 633 | 7e-116 | 377 | 35 | 55 | GO:0043679; C:axon terminus; IDA:RGD.::GO:0030425; C:dendrite; IDA:RGD.::GO:0005615; C:extracellular space; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.::GO:0030141; C:secretory granule; IDA:RGD.::GO:0005802; C:trans-Golgi network; IDA:RGD.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051087; F:chaperone binding; IPI:RGD.::GO:0043559; F:insulin binding; IPI:RGD.::GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0009790; P:embryo development; IEP:RGD.::GO:0022008; P:neurogenesis; IEP:RGD.::GO:0031016; P:pancreas development; IEP:RGD.::GO:0016486; P:peptide hormone processing; IDA:RGD.::GO:0021983; P:pituitary gland development; IEP:RGD.::GO:0050714; P:positive regulation of protein secretion; IDA:RGD.::GO:0016540; P:protein autoprocessing; IMP:RGD.::GO:0006508; P:proteolysis; IMP:RGD.::GO:0048678; P:response to axon injury; IEP:RGD.::GO:0051592; P:response to calcium ion; IEP:RGD.::GO:0010157; P:response to chlorate; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0070542; P:response to fatty acid; IEP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.::GO:0009749; P:response to glucose stimulus; IEP:RGD.::GO:0070555; P:response to interleukin-1; IEP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.::GO:0043278; P:response to morphine; IEP:RGD.::GO:0031667; P:response to nutrient levels; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IEP:RGD. | 7 | P29120 | 753 | NEC1_HUMAN Neuroendocrine convertase 1 OS=Hom... | 640 | 2e-115 | 376 | 35 | 54 | GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0005794; C:Golgi apparatus; IBA:RefGenome.::GO:0030141; C:secretory granule; TAS:Reactome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; ISS:BHF-UCL. | | | | | | | | | | GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.::GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0043043; P:peptide biosynthetic process; ISS:BHF-UCL.::GO:0016486; P:peptide hormone processing; TAS:Reactome.::GO:0006508; P:proteolysis; TAS:ProtInc.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 8 | P63240 | 753 | NEC1_MUSCO Neuroendocrine convertase 1 OS=Mus... | 641 | 3e-115 | 375 | 35 | 54 | GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 9 | P63239 | 753 | NEC1_MOUSE Neuroendocrine convertase 1 OS=Mus... | 641 | 9e-115 | 374 | 35 | 54 | GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0005794; C:Golgi apparatus; IBA:RefGenome.::GO:0030141; C:secretory granule; TAS:Reactome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.::GO:0016486; P:peptide hormone processing; IDA:BHF-UCL.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 10 | P23377 | 793 | FURIN_RAT Furin OS=Rattus norvegicus (Rat). G... | 530 | 5e-114 | 374 | 38 | 58 | GO:0005789; C:endoplasmic reticulum membrane; IDA:RGD.::GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0031985; C:Golgi cisterna; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IMP:RGD. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:RGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 11 | Q9GLR1 | 753 | NEC1_BOVIN Neuroendocrine convertase 1 OS=Bos... | 636 | 1e-113 | 371 | 35 | 55 | GO:0005615; C:extracellular space; ISS:RefGenome.::GO:0005794; C:Golgi apparatus; ISS:RefGenome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 12 | P09958 | 794 | FURIN_HUMAN Furin OS=Homo sapiens (Human). GN... | 503 | 8e-113 | 370 | 39 | 59 | GO:0009986; C:cell surface; IDA:BHF-UCL.::GO:0005796; C:Golgi lumen; TAS:Reactome.::GO:0000139; C:Golgi membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0045121; C:membrane raft; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005802; C:trans-Golgi network; IDA:BHF-UCL.::GO:0030140; C:trans-Golgi network transport vesicle; IDA:MGI. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0048406; F:nerve growth factor binding; IDA:BHF-UCL.::GO:0042277; F:peptide binding; IDA:BHF-UCL.::GO:0002020; F:protease binding; IPI:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.::GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:BHF-UCL. | | | | | | | | | | GO:0008283; P:cell proliferation; IMP:BHF-UCL.::GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.::GO:0032804; P:negative regulation of low-density lipoprotein particle receptor catabolic process; IDA:HGNC.::GO:0032911; P:negative regulation of transforming growth factor beta1 production; IMP:BHF-UCL.::GO:0032455; P:nerve growth factor processing; TAS:Reactome.::GO:0032902; P:nerve growth factor production; IDA:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.::GO:0017187; P:peptidyl-glutamic acid carboxylation; TAS:Reactome.::GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IC:BHF-UCL.::GO:0043687; P:post-translational protein modification; TAS:Reactome.::GO:0006508; P:proteolysis; TAS:Reactome.::GO:0032940; P:secretion by cell; IDA:BHF-UCL.::GO:0006465; P:signal peptide processing; IDA:HGNC.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.::GO:0019067; P:viral assembly, maturation, egress, and release; IEP:BHF-UCL. | 13 | P23188 | 793 | FURIN_MOUSE Furin OS=Mus musculus (Mouse). GN... | 534 | 1e-112 | 370 | 38 | 57 | GO:0005769; C:early endosome; TAS:MGI.::GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0016021; C:integral to membrane; TAS:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0012510; C:trans-Golgi network transport vesicle membrane; TAS:MGI. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 14 | Q28193 | 797 | FURIN_BOVIN Furin OS=Bos taurus (Bovine). GN=... | 535 | 2e-112 | 369 | 39 | 58 | GO:0005615; C:extracellular space; ISS:RefGenome.::GO:0005794; C:Golgi apparatus; ISS:RefGenome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 15 | Q78EH2 | 678 | PCSK4_RAT Proprotein convertase subtilisin/ke... | 508 | 1e-111 | 364 | 39 | 57 | | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0006508; P:proteolysis; IBA:RefGenome. | 16 | P29121 | 655 | PCSK4_MOUSE Proprotein convertase subtilisin/... | 487 | 8e-109 | 356 | 40 | 57 | GO:0002080; C:acrosomal membrane; IDA:MGI.::GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0007340; P:acrosome reaction; IMP:MGI.::GO:0007339; P:binding of sperm to zona pellucida; IMP:MGI.::GO:0006508; P:proteolysis; IBA:RefGenome.::GO:0048240; P:sperm capacitation; IMP:MGI. | 17 | Q6UW60 | 755 | PCSK4_HUMAN Proprotein convertase subtilisin/... | 514 | 3e-108 | 357 | 38 | 57 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0006508; P:proteolysis; IBA:RefGenome. | 18 | P29122 | 969 | PCSK6_HUMAN Proprotein convertase subtilisin/... | 583 | 3e-108 | 362 | 37 | 54 | GO:0009986; C:cell surface; IDA:BHF-UCL.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0031012; C:extracellular matrix; IDA:BHF-UCL.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0005796; C:Golgi lumen; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:BHF-UCL. | | | | | | | | | | GO:0043499; F:eukaryotic cell surface binding; IDA:BHF-UCL.::GO:0008201; F:heparin binding; IDA:BHF-UCL.::GO:0048406; F:nerve growth factor binding; IDA:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0009100; P:glycoprotein metabolic process; IDA:BHF-UCL.::GO:0032455; P:nerve growth factor processing; TAS:Reactome.::GO:0032902; P:nerve growth factor production; IDA:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030510; P:regulation of BMP signaling pathway; TAS:BHF-UCL.::GO:0032940; P:secretion by cell; IDA:BHF-UCL. | 19 | Q63415 | 937 | PCSK6_RAT Proprotein convertase subtilisin/ke... | 546 | 2e-107 | 359 | 38 | 55 | GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0005794; C:Golgi apparatus; IBA:RefGenome. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0016486; P:peptide hormone processing; IEP:RGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 20 | P29119 | 783 | FURI1_XENLA Furin-1 OS=Xenopus laevis (Africa... | 535 | 3e-107 | 355 | 37 | 56 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 21 | P21661 | 637 | NEC2_MOUSE Neuroendocrine convertase 2 OS=Mus... | 507 | 2e-106 | 349 | 40 | 58 | GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0034230; P:enkephalin processing; IDA:BHF-UCL.::GO:0007399; P:nervous system development; IEP:HGNC.::GO:0016540; P:protein autoprocessing; IDA:HGNC.::GO:0006508; P:proteolysis; IMP:MGI. | 22 | Q03333 | 638 | NEC2_PIG Neuroendocrine convertase 2 OS=Sus s... | 530 | 2e-106 | 349 | 38 | 59 | GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 23 | P28841 | 637 | NEC2_RAT Neuroendocrine convertase 2 OS=Rattu... | 510 | 2e-106 | 348 | 39 | 58 | GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct.::GO:0004252; F:serine-type endopeptidase activity; IMP:BHF-UCL. | | | | | | | | | | GO:0034231; P:islet amyloid polypeptide processing; IMP:BHF-UCL.::GO:0006508; P:proteolysis; IMP:RGD. | 24 | Q5REC2 | 638 | NEC2_PONAB Neuroendocrine convertase 2 OS=Pon... | 509 | 3e-106 | 348 | 39 | 59 | GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 25 | P16519 | 638 | NEC2_HUMAN Neuroendocrine convertase 2 OS=Hom... | 509 | 3e-106 | 348 | 39 | 59 | GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0016020; C:membrane; IDA:BHF-UCL.::GO:0030141; C:secretory granule; TAS:Reactome.::GO:0005625; C:soluble fraction; IDA:BHF-UCL.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0034230; P:enkephalin processing; ISS:BHF-UCL.::GO:0030070; P:insulin processing; IDA:BHF-UCL.::GO:0034231; P:islet amyloid polypeptide processing; ISS:BHF-UCL.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 26 | Q9GLR0 | 638 | NEC2_BOVIN Neuroendocrine convertase 2 OS=Bos... | 533 | 1e-105 | 347 | 38 | 58 | GO:0005615; C:extracellular space; ISS:RefGenome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome. | | | | | | | | | | GO:0007399; P:nervous system development; ISS:AgBase.::GO:0016486; P:peptide hormone processing; ISS:AgBase.::GO:0016540; P:protein autoprocessing; ISS:AgBase.::GO:0006508; P:proteolysis; ISS:AgBase. | 27 | P51559 | 943 | BLI4_CAEEL Endoprotease bli-4 OS=Caenorhabdit... | 506 | 6e-105 | 353 | 38 | 56 | GO:0016021; C:integral to membrane; NAS:UniProtKB.::GO:0005634; C:nucleus; IDA:WormBase. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; NAS:UniProtKB. | | | | | | | | | | GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0040002; P:collagen and cuticulin-based cuticle development; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 28 | Q16549 | 785 | PCSK7_HUMAN Proprotein convertase subtilisin/... | 529 | 3e-104 | 347 | 38 | 57 | GO:0030173; C:integral to Golgi membrane; IDA:UniProtKB. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0016486; P:peptide hormone processing; NAS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 29 | Q62849 | 783 | PCSK7_RAT Proprotein convertase subtilisin/ke... | 579 | 9e-104 | 346 | 37 | 55 | | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 30 | Q61139 | 770 | PCSK7_MOUSE Proprotein convertase subtilisin/... | 579 | 1e-103 | 345 | 36 | 54 | GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome. | | | | | | | | | | GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. | | | | | | | | | | GO:0016485; P:protein processing; IBA:RefGenome.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 31 | P30432 | 1679 | FUR2_DROME Furin-like protease 2 OS=Drosophil... | 540 | 2e-102 | 354 | 39 | 56 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; ISS:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IDA:FlyBase.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. |
