| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q58DL7 | 561 | ARHG9_BOVIN Rho guanine nucleotide exchange f... | 288 | 0.00000001 | 63.2 | 22 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 32 | P52734 | 960 | FGD1_MOUSE FYVE, RhoGEF and PH domain-contain... | 312 | 0.00000001 | 63.2 | 23 | 37 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0001726; C:ruffle; IDA:MGI. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0008360; P:regulation of cell shape; IDA:UniProtKB. | 33 | P98174 | 961 | FGD1_HUMAN FYVE, RhoGEF and PH domain-contain... | 312 | 0.00000002 | 62.8 | 24 | 37 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; IDA:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; IDA:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0009887; P:organ morphogenesis; TAS:ProtInc.::GO:0043088; P:regulation of Cdc42 GTPase activity; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 34 | O88842 | 733 | FGD3_MOUSE FYVE, RhoGEF and PH domain-contain... | 94 | 0.0002 | 49.7 | 34 | 55 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IDA:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 35 | Q21653 | 1182 | YNG2_CAEEL Uncharacterized protein R02F2.2 OS... | 287 | 0.00000002 | 62.4 | 24 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 36 | Q8CHE4 | 1687 | PHLP1_MOUSE PH domain leucine-rich repeat-con... | 195 | 6.7 | 35 | 23 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. | 37 | Q9ULL1 | 1385 | PKHG1_HUMAN Pleckstrin homology domain-contai... | 320 | 0.00000004 | 62 | 22 | 38 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 38 | B0W6M9 | 628 | SUR8_CULQU Leucine-rich repeat protein soc-2 ... | 85 | 0.82 | 37.7 | 28 | 49 | | | | | | | | | | | | | | | | | | | | | | 39 | Q8C033 | 1345 | ARHGA_MOUSE Rho guanine nucleotide exchange f... | 309 | 0.00000007 | 60.8 | 23 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 40 | P91620 | 2061 | SIF2_DROME Protein still life, isoforms C/SIF... | 328 | 0.00000008 | 60.8 | 23 | 40 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0050770; P:regulation of axonogenesis; IGI:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0050803; P:regulation of synapse structure and activity; TAS:FlyBase. | 41 | Q07139 | 913 | ECT2_MOUSE Protein ECT2 OS=Mus musculus (Mous... | 303 | 0.0000001 | 60.5 | 22 | 41 | GO:0097149; C:centralspindlin complex; ISS:UniProtKB.::GO:0032154; C:cleavage furrow; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0030496; C:midbody; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005923; C:tight junction; ISS:UniProtKB. | | | | | | | | | | GO:0005096; F:GTPase activator activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.::GO:0032863; P:activation of Rac GTPase activity; ISS:UniProtKB.::GO:0033205; P:cell cycle cytokinesis; ISS:UniProtKB.::GO:0000902; P:cell morphogenesis; IDA:MGI.::GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.::GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0043089; P:positive regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0071777; P:positive regulation of cell cycle cytokinesis; ISS:UniProtKB.::GO:0045666; P:positive regulation of neuron differentiation; IMP:UniProtKB.::GO:0042307; P:positive regulation of protein import into nucleus; IDA:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; ISS:UniProtKB.::GO:0070830; P:tight junction assembly; ISS:UniProtKB. | 42 | P97924 | 2959 | KALRN_RAT Kalirin OS=Rattus norvegicus (Rat).... | 77 | 0.27 | 39.7 | 29 | 45 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0043005; C:neuron projection; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0007409; P:axonogenesis; IDA:RGD.::GO:0035556; P:intracellular signal transduction; IDA:HGNC.::GO:0050773; P:regulation of dendrite development; IDA:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 43 | O60229 | 2985 | KALRN_HUMAN Kalirin OS=Homo sapiens (Human). ... | 77 | 0.26 | 39.7 | 29 | 45 | GO:0015629; C:actin cytoskeleton; TAS:ProtInc.::GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007399; P:nervous system development; ISS:HGNC.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0016192; P:vesicle-mediated transport; TAS:ProtInc. | 44 | A2CG49 | 2964 | KALRN_MOUSE Kalirin OS=Mus musculus (Mouse). ... | 77 | 0.26 | 39.7 | 29 | 45 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 45 | Q60610 | 1591 | TIAM1_MOUSE T-lymphoma invasion and metastasi... | 275 | 0.0000001 | 60.1 | 24 | 41 | GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0031547; P:brain-derived neurotrophic factor receptor signaling pathway; IDA:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; IDA:UniProtKB. | 46 | O88520 | 582 | SHOC2_MOUSE Leucine-rich repeat protein SHOC-... | 131 | 4.6 | 35 | 26 | 48 | GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000164; C:protein phosphatase type 1 complex; ISS:UniProtKB. | | | | | | | | | | GO:0019903; F:protein phosphatase binding; ISS:UniProtKB. | | | | | | | | | | GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB. | 47 | Q6AYI5 | 582 | SHOC2_RAT Leucine-rich repeat protein SHOC-2 ... | 131 | 4.1 | 35.4 | 26 | 48 | GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000164; C:protein phosphatase type 1 complex; ISS:UniProtKB. | | | | | | | | | | GO:0019903; F:protein phosphatase binding; ISS:UniProtKB. | | | | | | | | | | GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB. | 48 | Q13009 | 1591 | TIAM1_HUMAN T-lymphoma invasion and metastasi... | 274 | 0.0000002 | 59.7 | 24 | 41 | GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 49 | Q08DN7 | 844 | VAV_BOVIN Proto-oncogene vav OS=Bos taurus (B... | 168 | 0.0000002 | 58.9 | 28 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 50 | O61967 | 699 | LAP1_CAEEL Protein lap1 OS=Caenorhabditis ele... | 96 | 0.33 | 38.9 | 28 | 48 | GO:0005912; C:adherens junction; IDA:UniProtKB.::GO:0016323; C:basolateral plasma membrane; IDA:WormBase. | | | | | | | | | | | | | | | | | | | | GO:0030029; P:actin filament-based process; IMP:WormBase.::GO:0007155; P:cell adhesion; IMP:WormBase.::GO:0007043; P:cell-cell junction assembly; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0007163; P:establishment or maintenance of cell polarity; IEP:UniProtKB.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.::GO:0030728; P:ovulation; IMP:WormBase.::GO:0060465; P:pharynx development; IMP:WormBase.::GO:0015031; P:protein transport; IEP:UniProtKB.::GO:0045108; P:regulation of intermediate filament polymerization or depolymerization; IMP:UniProtKB. | 51 | Q5R5T1 | 737 | FGD3_PONAB FYVE, RhoGEF and PH domain-contain... | 94 | 0.00007 | 50.8 | 34 | 54 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 52 | Q9CRC8 | 602 | LRC40_MOUSE Leucine-rich repeat-containing pr... | 83 | 2.2 | 36.2 | 34 | 60 | | | | | | | | | | | | | | | | | | | | | | 53 | Q5JSP0 | 725 | FGD3_HUMAN FYVE, RhoGEF and PH domain-contain... | 94 | 0.00003 | 52.4 | 35 | 55 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 54 | Q9VEK6 | 641 | SUR8_DROME Leucine-rich repeat protein soc-2 ... | 122 | 3.3 | 35.8 | 29 | 41 | | | | | | | | | | | | | | | | | | | | | | 55 | Q01631 | 2300 | CYAA_NEUCR Adenylate cyclase OS=1257 / FGSC 9... | 129 | 2.1 | 36.6 | 25 | 47 | | | | | | | | | | | GO:0004016; F:adenylate cyclase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 56 | Q54C71 | 1125 | KXCB_DICDI Kinase and exchange factor for Rac... | 322 | 0.0000005 | 58.2 | 20 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 57 | Q6KAU7 | 1340 | PKHG2_MOUSE Pleckstrin homology domain-contai... | 291 | 0.0000006 | 58.2 | 21 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 58 | F1MCA7 | 1536 | LRRC7_BOVIN Leucine-rich repeat-containing pr... | 100 | 0.027 | 42.7 | 28 | 44 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | | 59 | B4JTV9 | 622 | SUR8_DROGR Leucine-rich repeat protein soc-2 ... | 85 | 1.8 | 36.6 | 28 | 47 | | | | | | | | | | | | | | | | | | | | | | 60 | Q22875 | 559 | SHOC2_CAEEL Leucine-rich repeat protein soc-2... | 102 | 0.88 | 37.4 | 32 | 53 | | | | | | | | | | | | | | | | | | | | | GO:0008543; P:fibroblast growth factor receptor signaling pathway; IGI:WormBase.::GO:0007517; P:muscle organ development; IMP:WormBase.::GO:0046579; P:positive regulation of Ras protein signal transduction; IMP:UniProtKB.::GO:0031344; P:regulation of cell projection organization; IMP:WormBase.::GO:0040025; P:vulval development; IMP:UniProtKB. | 61 | B4LXW1 | 614 | SUR8_DROVI Leucine-rich repeat protein soc-2 ... | 85 | 3.5 | 35.8 | 28 | 48 | | | | | | | | | | | | | | | | | | | | | |
