rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
121 | Q3UMG5 | 773 | LRCH2_MOUSE Leucine-rich repeat and calponin ... | 100 | 1.6 | 37 | 27 | 46 | | | | | | | | | | | | | | | | | | | | | | 122 | P52735 | 878 | VAV2_HUMAN Guanine nucleotide exchange factor... | 104 | 0.00003 | 52.4 | 33 | 55 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 123 | Q4R3P6 | 602 | LRC40_MACFA Leucine-rich repeat-containing pr... | 82 | 1.8 | 36.6 | 32 | 51 | | | | | | | | | | | | | | | | | | | | | | 124 | Q9H9A6 | 602 | LRC40_HUMAN Leucine-rich repeat-containing pr... | 100 | 6.2 | 34.7 | 25 | 52 | | | | | | | | | | | | | | | | | | | | | | 125 | Q5RFE9 | 602 | LRC40_PONAB Leucine-rich repeat-containing pr... | 100 | 5.5 | 35 | 25 | 52 | | | | | | | | | | | | | | | | | | | | | | 126 | Q9Z1I6 | 919 | ARHG1_RAT Rho guanine nucleotide exchange fac... | 293 | 0.00003 | 52.4 | 22 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 127 | Q9NZM3 | 1697 | ITSN2_HUMAN Intersectin-2 OS=Homo sapiens (Hu... | 90 | 0.00003 | 52.4 | 36 | 54 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 128 | Q5VUJ6 | 765 | LRCH2_HUMAN Leucine-rich repeat and calponin ... | 100 | 1.1 | 37.4 | 28 | 46 | | | | | | | | | | | | | | | | | | | | | | 129 | Q8K3W2 | 274 | LRC10_MOUSE Leucine-rich repeat-containing pr... | 98 | 0.004 | 44.3 | 34 | 51 | GO:0005856; C:cytoskeleton; IDA:MGI.::GO:0005739; C:mitochondrion; IDA:MGI.::GO:0030016; C:myofibril; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI. | | | | | | | | | | | | | | | | | | | | | 130 | Q9H7P9 | 1386 | PKHG2_HUMAN Pleckstrin homology domain-contai... | 293 | 0.00004 | 52 | 22 | 41 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 131 | A4D1F6 | 860 | LRRD1_HUMAN Leucine-rich repeat and death dom... | 104 | 0.21 | 39.7 | 29 | 45 | | | | | | | | | | | | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 132 | A7SFP1 | 577 | SHOC2_NEMVE Leucine-rich repeat protein soc-2... | 98 | 3.8 | 35.4 | 26 | 47 | | | | | | | | | | | | | | | | | | | | | | 133 | B0M0P8 | 2356 | GEFL_DICDI Ras guanine nucleotide exchange fa... | 129 | 0.006 | 45.1 | 29 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0003779; F:actin binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017048; F:Rho GTPase binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.::GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase.::GO:0043052; P:thermotaxis; IMP:dictyBase. | 134 | Q8BXA7 | 1320 | PHLP2_MOUSE PH domain leucine-rich repeat-con... | 83 | 0.009 | 44.3 | 35 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 135 | O15013 | 1369 | ARHGA_HUMAN Rho guanine nucleotide exchange f... | 242 | 1 | 37.7 | 22 | 37 | GO:0005813; C:centrosome; IDA:BHF-UCL.::GO:0005829; C:cytosol; NAS:BHF-UCL.::GO:0005625; C:soluble fraction; IDA:BHF-UCL. | | | | | | | | | | GO:0019894; F:kinesin binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:BHF-UCL. | | | | | | | | | | GO:0051298; P:centrosome duplication; IMP:BHF-UCL.::GO:0022011; P:myelination in peripheral nervous system; IMP:BHF-UCL.::GO:0033126; P:positive regulation of GTP catabolic process; IDA:BHF-UCL.::GO:0051496; P:positive regulation of stress fiber assembly; IMP:BHF-UCL.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0090307; P:spindle assembly involved in mitosis; IMP:BHF-UCL. | 136 | Q5M8G4 | 605 | LRC40_XENTR Leucine-rich repeat-containing pr... | 129 | 7.1 | 34.7 | 25 | 45 | | | | | | | | | | | | | | | | | | | | | | 137 | A6NIV6 | 560 | LRIQ4_HUMAN Leucine-rich repeat and IQ domain... | 108 | 1.3 | 37 | 28 | 48 | | | | | | | | | | | | | | | | | | | | | | 138 | Q1L8Y7 | 561 | SHOC2_DANRE Leucine-rich repeat protein SHOC-... | 84 | 9.8 | 34.3 | 29 | 48 | GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000164; C:protein phosphatase type 1 complex; ISS:UniProtKB. | | | | | | | | | | GO:0019903; F:protein phosphatase binding; ISS:UniProtKB. | | | | | | | | | | GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB. | 139 | Q553D3 | 1173 | GXCJJ_DICDI Rac guanine nucleotide exchange f... | 87 | 0.00007 | 51.2 | 33 | 56 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 140 | A2AWP8 | 1280 | ARGAL_MOUSE Rho guanine nucleotide exchange f... | 221 | 0.00008 | 51.2 | 24 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 141 | Q6TXD4 | 1580 | DNMBP_MOUSE Dynamin-binding protein OS=Mus mu... | 281 | 0.00008 | 51.2 | 22 | 39 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 142 | O22938 | 890 | Y2182_ARATH Leucine-rich repeat receptor-like... | 263 | 0.00008 | 50.8 | 24 | 42 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 143 | Q05C16 | 580 | LRC63_HUMAN Leucine-rich repeat-containing pr... | 99 | 0.19 | 39.7 | 27 | 46 | | | | | | | | | | | | | | | | | | | | | | 144 | Q29RM4 | 1237 | ARGAL_BOVIN Rho guanine nucleotide exchange f... | 221 | 0.0001 | 50.8 | 24 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 145 | Q5RDX5 | 709 | NGEF_PONAB Ephexin-1 OS=Pongo abelii (Sumatra... | 230 | 0.0001 | 50.4 | 23 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 146 | A4IIK1 | 997 | MFHA1_XENTR Malignant fibrous histiocytoma-am... | 107 | 0.07 | 41.2 | 30 | 47 | | | | | | | | | | | GO:0005525; F:GTP binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 147 | Q5FVI3 | 239 | LRC57_RAT Leucine-rich repeat-containing prot... | 109 | 0.0001 | 48.9 | 34 | 54 | | | | | | | | | | | | | | | | | | | | | | 148 | Q9Y4F1 | 1045 | FARP1_HUMAN FERM, RhoGEF and pleckstrin domai... | 325 | 0.0001 | 50.4 | 22 | 39 | GO:0005737; C:cytoplasm; IEA:InterPro.::GO:0005856; C:cytoskeleton; TAS:ProtInc.::GO:0019898; C:extrinsic to membrane; IEA:InterPro. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 149 | Q8N5V2 | 710 | NGEF_HUMAN Ephexin-1 OS=Homo sapiens (Human).... | 230 | 0.0001 | 50.1 | 23 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 150 | Q60992 | 868 | VAV2_MOUSE Guanine nucleotide exchange factor... | 104 | 0.0002 | 50.1 | 31 | 55 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005154; F:epidermal growth factor receptor binding; IPI:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IGI:MGI.::GO:0030032; P:lamellipodium assembly; IGI:MGI.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI. | 151 | Q86YR7 | 1114 | MF2L2_HUMAN Probable guanine nucleotide excha... | 97 | 0.0002 | 50.1 | 32 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |