| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | B2RTY4 | 2548 | MYO9A_HUMAN Unconventional myosin-IXa OS=Homo... | 154 | 0.00000000005 | 68.9 | 29 | 52 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0016461; C:unconventional myosin complex; NAS:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0007601; P:visual perception; TAS:ProtInc. | 62 | Q54G18 | 1115 | GACW_DICDI Rho GTPase-activating protein gacW... | 160 | 0.00000000005 | 68.6 | 26 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 63 | P0CAX5 | 802 | OPHN1_RAT Oligophrenin-1 OS=Rattus norvegicus... | 220 | 0.00000000007 | 68.2 | 24 | 45 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0035255; F:ionotropic glutamate receptor binding; IPI:RGD.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro. | 64 | Q7YQL5 | 802 | OPHN1_PONPY Oligophrenin-1 OS=Pongo pygmaeus ... | 220 | 0.00000000007 | 67.8 | 25 | 45 | GO:0030424; C:axon; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro. | 65 | Q7YQL6 | 802 | OPHN1_PANTR Oligophrenin-1 OS=Pan troglodytes... | 220 | 0.00000000007 | 67.8 | 25 | 45 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro. | 66 | O60890 | 802 | OPHN1_HUMAN Oligophrenin-1 OS=Homo sapiens (H... | 220 | 0.00000000007 | 67.8 | 25 | 45 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005100; F:Rho GTPase activator activity; TAS:ProtInc.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:ProtInc.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0006930; P:substrate-dependent cell migration, cell extension; TAS:ProtInc. | 67 | O14559 | 1287 | RHG33_HUMAN Rho GTPase-activating protein 33 ... | 216 | 0.00000000008 | 68.2 | 25 | 47 | | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro. | 68 | Q99J31 | 802 | OPHN1_MOUSE Oligophrenin-1 OS=Mus musculus (M... | 220 | 0.00000000009 | 67.8 | 24 | 45 | GO:0015629; C:actin cytoskeleton; IDA:MGI.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.::GO:0043195; C:terminal button; IDA:MGI. | | | | | | | | | | GO:0003779; F:actin binding; IDA:MGI.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005100; F:Rho GTPase activator activity; IMP:MGI.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IDA:MGI.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0030100; P:regulation of endocytosis; IMP:MGI.::GO:0051966; P:regulation of synaptic transmission, glutamatergic; IMP:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0048488; P:synaptic vesicle endocytosis; IMP:MGI. | 69 | Q640N3 | 1101 | RHG30_MOUSE Rho GTPase-activating protein 30 ... | 221 | 0.00000000009 | 67.8 | 24 | 48 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 70 | A6NI28 | 874 | RHG42_HUMAN Rho GTPase-activating protein 42 ... | 222 | 0.00000000009 | 67.8 | 26 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro. | 71 | P11274 | 1271 | BCR_HUMAN Breakpoint cluster region protein O... | 152 | 0.0000000001 | 67.8 | 26 | 49 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 72 | Q86IG9 | 566 | GACH_DICDI Rho GTPase-activating protein gacH... | 183 | 0.0000000001 | 67.4 | 25 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 73 | Q6PAJ1 | 1270 | BCR_MOUSE Breakpoint cluster region protein O... | 152 | 0.0000000001 | 67.4 | 26 | 49 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0030675; F:Rac GTPase activator activity; IGI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IGI:MGI.::GO:0007420; P:brain development; IGI:MGI.::GO:0042472; P:inner ear morphogenesis; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030336; P:negative regulation of cell migration; IGI:MGI.::GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.::GO:0043314; P:negative regulation of neutrophil degranulation; IGI:MGI.::GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.::GO:0050766; P:positive regulation of phagocytosis; IGI:MGI.::GO:0051726; P:regulation of cell cycle; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; IMP:MGI. | 74 | Q5ZMW5 | 760 | RHG26_CHICK Rho GTPase-activating protein 26 ... | 224 | 0.0000000002 | 67 | 24 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro. | 75 | A6QNS3 | 859 | ABR_BOVIN Active breakpoint cluster region-re... | 152 | 0.0000000002 | 66.6 | 27 | 51 | | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 76 | Q12979 | 859 | ABR_HUMAN Active breakpoint cluster region-re... | 152 | 0.0000000002 | 66.2 | 27 | 51 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 77 | Q5SSL4 | 859 | ABR_MOUSE Active breakpoint cluster region-re... | 152 | 0.0000000002 | 66.2 | 27 | 51 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IGI:MGI.::GO:0007420; P:brain development; IGI:MGI.::GO:0042472; P:inner ear morphogenesis; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030336; P:negative regulation of cell migration; IGI:MGI.::GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.::GO:0043314; P:negative regulation of neutrophil degranulation; IGI:MGI.::GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.::GO:0050766; P:positive regulation of phagocytosis; IGI:MGI.::GO:0032496; P:response to lipopolysaccharide; IMP:MGI. | 78 | Q54FG5 | 873 | GACJJ_DICDI Rho GTPase-activating protein gac... | 182 | 0.0000000002 | 66.2 | 25 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 79 | A4II46 | 862 | ABR_XENTR Active breakpoint cluster region-re... | 152 | 0.0000000003 | 66.2 | 27 | 50 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 80 | Q80YF9 | 1305 | RHG33_MOUSE Rho GTPase-activating protein 33 ... | 214 | 0.0000000003 | 66.2 | 25 | 47 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:MGI. | | | | | | | | | | GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro. | 81 | Q8IWW6 | 846 | RHG12_HUMAN Rho GTPase-activating protein 12 ... | 188 | 0.0000000005 | 65.5 | 25 | 46 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 82 | Q9BE31 | 847 | RHG12_MACFA Rho GTPase-activating protein 12 ... | 188 | 0.0000000005 | 65.5 | 26 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 83 | Q54MV3 | 906 | GACJ_DICDI Rho GTPase-activating protein gacJ... | 154 | 0.0000000006 | 65.1 | 27 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 84 | Q8K0Q5 | 663 | RHG18_MOUSE Rho GTPase-activating protein 18 ... | 183 | 0.0000000007 | 64.7 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 85 | Q91Z69 | 1062 | SRGP1_MOUSE SLIT-ROBO Rho GTPase-activating p... | 233 | 0.0000000007 | 65.1 | 23 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005100; F:Rho GTPase activator activity; IDA:MGI.::GO:0017048; F:Rho GTPase binding; IDA:MGI. | | | | | | | | | | GO:0016477; P:cell migration; IDA:MGI.::GO:0007266; P:Rho protein signal transduction; IDA:MGI. | 86 | B2RQE8 | 841 | RHG42_MOUSE Rho GTPase-activating protein 42 ... | 220 | 0.0000000008 | 64.7 | 25 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro. | 87 | P85298 | 464 | RHG08_HUMAN Rho GTPase-activating protein 8 O... | 169 | 0.0000000009 | 63.9 | 27 | 48 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005515; F:protein binding; IPI:BHF-UCL.::GO:0005100; F:Rho GTPase activator activity; IDA:BHF-UCL. | | | | | | | | | | GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 88 | Q8AVG0 | 862 | ABR_XENLA Active breakpoint cluster region-re... | 152 | 0.000000001 | 64.3 | 26 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 89 | Q6REY9 | 1182 | RHG20_RAT Rho GTPase-activating protein 20 OS... | 167 | 0.000000001 | 64.3 | 28 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017048; F:Rho GTPase binding; TAS:RGD. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; TAS:RGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 90 | Q9UNA1 | 814 | RHG26_HUMAN Rho GTPase-activating protein 26 ... | 240 | 0.000000001 | 64.3 | 25 | 45 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005100; F:Rho GTPase activator activity; NAS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0007399; P:nervous system development; NAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 91 | Q8C0D4 | 838 | RHG12_MOUSE Rho GTPase-activating protein 12 ... | 153 | 0.000000001 | 64.3 | 26 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. |
