| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q5MNU5 | 1279 | SCAP_PIG Sterol regulatory element-binding pr... | 469 | 1e-25 | 119 | 27 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. | 2 | A2RRU4 | 1276 | SCAP_RAT Sterol regulatory element-binding pr... | 483 | 1e-24 | 115 | 25 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD. | | | | | | | | | | | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. | 3 | Q6GQT6 | 1276 | SCAP_MOUSE Sterol regulatory element-binding ... | 483 | 4e-24 | 114 | 25 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0015485; F:cholesterol binding; TAS:MGI.::GO:0005515; F:protein binding; IPI:MGI. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IDA:MGI.::GO:0045540; P:regulation of cholesterol biosynthetic process; IMP:MGI.::GO:0042304; P:regulation of fatty acid biosynthetic process; IMP:MGI.::GO:0001666; P:response to hypoxia; IMP:MGI.::GO:0032868; P:response to insulin stimulus; IMP:MGI. | 4 | A6QM06 | 1278 | SCAP_BOVIN Sterol regulatory element-binding ... | 483 | 4e-23 | 110 | 25 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. | 5 | P97260 | 1276 | SCAP_CRIGR Sterol regulatory element-binding ... | 168 | 5e-23 | 110 | 38 | 57 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008022; F:protein C-terminus binding; IPI:UniProtKB. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0006994; P:positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; ISS:UniProtKB.::GO:0006993; P:sterol regulatory element binding protein import into nucleus involved in sterol depletion response; IMP:UniProtKB. | 6 | Q12770 | 1279 | SCAP_HUMAN Sterol regulatory element-binding ... | 168 | 1e-22 | 109 | 37 | 57 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; NAS:UniProtKB. | | | | | | | | | | GO:0051082; F:unfolded protein binding; NAS:UniProtKB. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0045541; P:negative regulation of cholesterol biosynthetic process; NAS:UniProtKB.::GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; NAS:UniProtKB.::GO:0006994; P:positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; IMP:UniProtKB. | 7 | A0JPH4 | 1311 | SCAP_XENLA Sterol regulatory element-binding ... | 193 | 2e-22 | 108 | 34 | 54 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. | 8 | O43043 | 1086 | SCAP_SCHPO Sterol regulatory element-binding ... | 173 | 0.0000000000004 | 78.2 | 31 | 50 | GO:0071458; C:integral to cytosolic side of endoplasmic reticulum membrane; TAS:PomBase.::GO:0030173; C:integral to Golgi membrane; TAS:PomBase.::GO:0032936; C:SREBP-SCAP complex; IDA:PomBase. | | | | | | | | | | GO:0032810; F:sterol response element binding; IDA:PomBase.::GO:0032935; F:sterol sensor activity; TAS:PomBase. | | | | | | | | | | GO:0071456; P:cellular response to hypoxia; TAS:PomBase.::GO:0035437; P:maintenance of protein localization in endoplasmic reticulum; IMP:PomBase.::GO:0072592; P:oxygen metabolic process; IMP:PomBase.::GO:0070452; P:positive regulation of ergosterol biosynthetic process; IMP:PomBase.::GO:0071073; P:positive regulation of phospholipid biosynthetic process; TAS:PomBase.::GO:0035104; P:positive regulation of transcription via sterol regulatory element binding; IMP:PomBase.::GO:0050821; P:protein stabilization; IMP:PomBase.::GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.::GO:0035103; P:sterol regulatory element binding protein cleavage; IMP:PomBase.::GO:0019432; P:triglyceride biosynthetic process; NAS:PomBase. | 9 | O35595 | 1182 | PTC2_MOUSE Protein patched homolog 2 OS=Mus m... | 156 | 0.000000005 | 64.7 | 26 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008158; F:hedgehog receptor activity; IEA:InterPro. | | | | | | | | | | GO:0042633; P:hair cycle; IMP:MGI.::GO:0043588; P:skin development; IMP:MGI. | 10 | Q61115 | 1434 | PTC1_MOUSE Protein patched homolog 1 OS=Mus m... | 160 | 0.00000005 | 61.2 | 28 | 44 | GO:0005576; C:extracellular region; TAS:Roslin.::GO:0005887; C:integral to plasma membrane; TAS:MGI.::GO:0030496; C:midbody; IDA:UniProtKB. | | | | | | | | | | GO:0015485; F:cholesterol binding; TAS:Roslin.::GO:0030332; F:cyclin binding; IPI:BHF-UCL.::GO:0008158; F:hedgehog receptor activity; TAS:MGI.::GO:0008201; F:heparin binding; IDA:Roslin.::GO:0005113; F:patched binding; IDA:Roslin.::GO:0032403; F:protein complex binding; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; NAS:Roslin. | | | | | | | | | | GO:0007420; P:brain development; IMP:BHF-UCL.::GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI.::GO:0061005; P:cell differentiation involved in kidney development; IGI:MGI.::GO:0072203; P:cell proliferation involved in metanephros development; IMP:MGI.::GO:0071397; P:cellular response to cholesterol; IEP:BHF-UCL.::GO:0021904; P:dorsal/ventral neural tube patterning; IMP:MGI.::GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.::GO:0008544; P:epidermis development; IMP:MGI.::GO:0042593; P:glucose homeostasis; IMP:MGI.::GO:0003007; P:heart morphogenesis; IMP:MGI.::GO:0035137; P:hindlimb morphogenesis; IMP:MGI.::GO:0043616; P:keratinocyte proliferation; IMP:MGI.::GO:0060603; P:mammary gland duct morphogenesis; IMP:MGI.::GO:0060644; P:mammary gland epithelial cell differentiation; IMP:MGI.::GO:0051782; P:negative regulation of cell division; IMP:BHF-UCL.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:MGI.::GO:0045879; P:negative regulation of smoothened signaling pathway; IGI:BHF-UCL.::GO:0021997; P:neural plate axis specification; IMP:BHF-UCL.::GO:0001843; P:neural tube closure; IMP:MGI.::GO:0016485; P:protein processing; IMP:MGI.::GO:0007346; P:regulation of mitotic cell cycle; IMP:MGI.::GO:0032880; P:regulation of protein localization; IDA:BHF-UCL.::GO:0010157; P:response to chlorate; IDA:MGI.::GO:0007224; P:smoothened signaling pathway; IDA:MGI.::GO:0061053; P:somite development; IMP:BHF-UCL. | 11 | Q13635 | 1447 | PTC1_HUMAN Protein patched homolog 1 OS=Homo ... | 160 | 0.00000005 | 61.2 | 28 | 44 | GO:0005901; C:caveola; IDA:BHF-UCL.::GO:0005887; C:integral to plasma membrane; ISS:BHF-UCL.::GO:0043231; C:intracellular membrane-bounded organelle; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL. | | | | | | | | | | GO:0015485; F:cholesterol binding; IDA:BHF-UCL.::GO:0030332; F:cyclin binding; IPI:BHF-UCL.::GO:0097108; F:hedgehog family protein binding; IPI:BHF-UCL.::GO:0008158; F:hedgehog receptor activity; IEA:InterPro.::GO:0005119; F:smoothened binding; IPI:BHF-UCL. | | | | | | | | | | GO:0007420; P:brain development; ISS:BHF-UCL.::GO:0071397; P:cellular response to cholesterol; IMP:BHF-UCL.::GO:0030326; P:embryonic limb morphogenesis; ISS:UniProtKB.::GO:0040015; P:negative regulation of multicellular organism growth; ISS:UniProtKB.::GO:0045668; P:negative regulation of osteoblast differentiation; IMP:BHF-UCL.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0045879; P:negative regulation of smoothened signaling pathway; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0021997; P:neural plate axis specification; ISS:BHF-UCL.::GO:0060037; P:pharyngeal system development; IMP:BHF-UCL.::GO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL.::GO:0016485; P:protein processing; ISS:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; IDA:BHF-UCL.::GO:0007224; P:smoothened signaling pathway; IEP:UniProtKB.::GO:0061053; P:somite development; IMP:BHF-UCL. | 12 | Q90693 | 1442 | PTC1_CHICK Protein patched homolog 1 OS=Gallu... | 160 | 0.00000005 | 61.2 | 28 | 44 | GO:0005887; C:integral to plasma membrane; NAS:Roslin. | | | | | | | | | | GO:0008158; F:hedgehog receptor activity; IEA:InterPro. | | | | | | | | | | GO:0007224; P:smoothened signaling pathway; NAS:Roslin. | 13 | Q9Y6C5 | 1203 | PTC2_HUMAN Protein patched homolog 2 OS=Homo ... | 156 | 0.0000002 | 59.3 | 24 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0097108; F:hedgehog family protein binding; IPI:BHF-UCL.::GO:0008158; F:hedgehog receptor activity; TAS:BHF-UCL.::GO:0005119; F:smoothened binding; IPI:BHF-UCL. | | | | | | | | | | GO:0045879; P:negative regulation of smoothened signaling pathway; TAS:BHF-UCL. | 14 | Q0EEE2 | 906 | PTHD3_MOUSE Patched domain-containing protein... | 165 | 0.000001 | 56.6 | 23 | 50 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008158; F:hedgehog receptor activity; IEA:InterPro. | | | | | | | | | | | 15 | Q98864 | 1220 | PTC1_DANRE Protein patched homolog 1 OS=Danio... | 158 | 0.00003 | 52 | 28 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008158; F:hedgehog receptor activity; IEA:InterPro. | | | | | | | | | | | 16 | Q12200 | 1170 | NPC1_YEAST Niemann-Pick type C-related protei... | 185 | 0.0004 | 48.5 | 23 | 45 | GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008158; F:hedgehog receptor activity; IEA:InterPro.::GO:0046624; F:sphingolipid transporter activity; IMP:SGD. | | | | | | | | | | GO:0006665; P:sphingolipid metabolic process; IMP:SGD. | 17 | Q9UHC9 | 1359 | NPCL1_HUMAN Niemann-Pick C1-like protein 1 OS... | 192 | 0.009 | 44.3 | 24 | 48 | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IDA:UniProtKB. | | | | | | | | | | GO:0008158; F:hedgehog receptor activity; IEA:InterPro.::GO:0031489; F:myosin V binding; IPI:UniProtKB.::GO:0017137; F:Rab GTPase binding; IPI:UniProtKB. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IMP:HGNC.::GO:0030299; P:intestinal cholesterol absorption; IMP:HGNC.::GO:0042157; P:lipoprotein metabolic process; IMP:HGNC. | 18 | Q09614 | 1408 | PTC1_CAEEL Protein patched homolog 1 OS=Caeno... | 172 | 0.031 | 42.4 | 22 | 42 | GO:0005887; C:integral to plasma membrane; IDA:WormBase. | | | | | | | | | | GO:0008158; F:hedgehog receptor activity; IEA:InterPro. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase. | 19 | P87314 | 932 | HIR1_SCHPO Protein hir1 OS=Schizosaccharomyce... | 98 | 0.037 | 42 | 30 | 45 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0000417; C:HIR complex; IDA:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase. | | | | | | | | | | GO:0003682; F:chromatin binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003714; F:transcription corepressor activity; TAS:PomBase. | | | | | | | | | | GO:0006995; P:cellular response to nitrogen starvation; IMP:PomBase.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:PomBase.::GO:0006336; P:DNA replication-independent nucleosome assembly; TAS:PomBase.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:0007070; P:negative regulation of transcription from RNA polymerase II promoter during mitosis; IMP:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 20 | Q6T3U3 | 1331 | NPCL1_RAT Niemann-Pick C1-like protein 1 OS=R... | 246 | 0.045 | 42 | 23 | 43 | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0031526; C:brush border membrane; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008144; F:drug binding; IDA:RGD.::GO:0008158; F:hedgehog receptor activity; IEA:InterPro. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0030301; P:cholesterol transport; IEA:InterPro.::GO:0042493; P:response to drug; IEP:RGD. | 21 | Q05B17 | 678 | WDR48_XENTR WD repeat-containing protein 48 O... | 119 | 0.048 | 41.6 | 29 | 51 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | GO:0016579; P:protein deubiquitination; ISS:UniProtKB. | 22 | Q6PFM9 | 677 | WDR48_DANRE WD repeat-containing protein 48 O... | 105 | 0.062 | 41.2 | 30 | 52 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | GO:0016579; P:protein deubiquitination; ISS:UniProtKB. | 23 | Q5F3K4 | 678 | WDR48_CHICK WD repeat-containing protein 48 O... | 105 | 0.077 | 40.8 | 30 | 52 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | GO:0016579; P:protein deubiquitination; ISS:UniProtKB. | 24 | Q03602 | 844 | PTR9_CAEEL Patched-related protein 9 OS=Caeno... | 155 | 0.09 | 40.8 | 23 | 48 | GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | | | | | | | | | | | GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase. | 25 | Q8TAF3 | 677 | WDR48_HUMAN WD repeat-containing protein 48 O... | 105 | 0.1 | 40.4 | 30 | 52 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0016579; P:protein deubiquitination; IDA:UniProtKB. | 26 | Q8BH57 | 676 | WDR48_MOUSE WD repeat-containing protein 48 O... | 105 | 0.1 | 40.4 | 30 | 52 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | GO:0016579; P:protein deubiquitination; ISS:UniProtKB. | 27 | Q32PG3 | 677 | WDR48_BOVIN WD repeat-containing protein 48 O... | 105 | 0.11 | 40.4 | 30 | 52 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | GO:0016579; P:protein deubiquitination; ISS:UniProtKB. | 28 | Q5RAW8 | 677 | WDR48_PONAB WD repeat-containing protein 48 O... | 105 | 0.11 | 40.4 | 30 | 52 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | GO:0016579; P:protein deubiquitination; ISS:UniProtKB. | 29 | Q4R2Z6 | 622 | WDR48_MACFA WD repeat-containing protein 48 O... | 105 | 0.13 | 40 | 30 | 52 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | GO:0016579; P:protein deubiquitination; ISS:UniProtKB. | 30 | Q6T3U4 | 1333 | NPCL1_MOUSE Niemann-Pick C1-like protein 1 OS... | 248 | 0.15 | 40 | 24 | 43 | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008158; F:hedgehog receptor activity; IEA:InterPro. | | | | | | | | | | GO:0042632; P:cholesterol homeostasis; IMP:MGI. | 31 | Q2KIG2 | 334 | WDR5_BOVIN WD repeat-containing protein 5 OS=... | 261 | 0.36 | 38.5 | 23 | 41 | GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB.::GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0048188; C:Set1C/COMPASS complex; ISS:UniProtKB. | | | | | | | | | | GO:0035064; F:methylated histone residue binding; ISS:UniProtKB. | | | | | | | | | | GO:0051568; P:histone H3-K4 methylation; ISS:UniProtKB.::GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.::GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.::GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
