| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P11586 | 935 | C1TC_HUMAN C-1-tetrahydrofolate synthase, cyt... | 939 | 0 | 1115 | 60 | 75 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; TAS:ProtInc. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:Reactome.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:Reactome.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.::GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity; TAS:Reactome. | | | | | | | | | | GO:0046655; P:folic acid metabolic process; TAS:Reactome.::GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.] | 2 | P27653 | 935 | C1TC_RAT C-1-tetrahydrofolate synthase, cytop... | 939 | 0 | 1105 | 59 | 75 | GO:0005737; C:cytoplasm; TAS:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:RGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:RGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.::GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity; TAS:RGD. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEP:RGD.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; TAS:RGD.] | 3 | Q5R8P0 | 935 | C1TC_PONAB C-1-tetrahydrofolate synthase, cyt... | 939 | 0 | 1101 | 60 | 75 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 4 | Q8WZJ7 | 937 | C1TC_SCHPO C-1-tetrahydrofolate synthase, cyt... | 938 | 0 | 1100 | 60 | 77 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:PomBase.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IDA:PomBase.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IDA:PomBase.::GO:0003697; F:single-stranded DNA binding; IDA:PomBase. | | | | | | | | | | GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IDA:PomBase.::GO:0046656; P:folic acid biosynthetic process; IDA:PomBase.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IDA:PomBase.::GO:0009113; P:purine base biosynthetic process; IDA:PomBase.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 5 | Q922D8 | 935 | C1TC_MOUSE C-1-tetrahydrofolate synthase, cyt... | 939 | 0 | 1099 | 60 | 75 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IMP:MGI.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0006548; P:histidine catabolic process; IMP:MGI.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 6 | O43007 | 969 | C1TM_SCHPO C-1-tetrahydrofolate synthase, mit... | 951 | 0 | 1050 | 55 | 73 | GO:0005739; C:mitochondrion; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; ISS:PomBase.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; ISS:PomBase.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; ISS:PomBase. | | | | | | | | | | GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; ISS:PomBase.::GO:0046656; P:folic acid biosynthetic process; ISS:PomBase.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; ISS:PomBase.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 7 | P09440 | 975 | C1TM_YEAST C-1-tetrahydrofolate synthase, mit... | 943 | 0 | 1045 | 56 | 73 | GO:0005739; C:mitochondrion; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:SGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IDA:SGD.::GO:0004479; F:methionyl-tRNA formyltransferase activity; IMP:SGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IDA:SGD. | | | | | | | | | | GO:0046656; P:folic acid biosynthetic process; IDA:SGD.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 8 | Q27772 | 933 | C1TC_SPOFR C-1-tetrahydrofolate synthase, cyt... | 935 | 0 | 1030 | 56 | 73 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 9 | O96553 | 968 | C1TC_DROME C-1-tetrahydrofolate synthase, cyt... | 946 | 0 | 1030 | 56 | 73 | GO:0005737; C:cytoplasm; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; NAS:UniProtKB.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; NAS:UniProtKB.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; NAS:UniProtKB. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 10 | P07245 | 946 | C1TC_YEAST C-1-tetrahydrofolate synthase, cyt... | 958 | 0 | 1022 | 56 | 72 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IMP:SGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IMP:SGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IMP:SGD. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; IMP:SGD.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 11 | Q0VCR7 | 975 | C1TM_BOVIN Monofunctional C1-tetrahydrofolate... | 937 | 0 | 914 | 53 | 68 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 12 | Q6UB35 | 978 | C1TM_HUMAN Monofunctional C1-tetrahydrofolate... | 939 | 0 | 895 | 52 | 67 | GO:0005739; C:mitochondrion; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:BHF-UCL.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:BHF-UCL.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0015942; P:formate metabolic process; IDA:BHF-UCL.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:BHF-UCL. | 13 | Q3V3R1 | 977 | C1TM_MOUSE Monofunctional C1-tetrahydrofolate... | 936 | 0 | 885 | 52 | 67 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 14 | Q9SPK5 | 634 | FTHS_ARATH Formate--tetrahydrofolate ligase O... | 636 | 0 | 801 | 63 | 77 | GO:0048046; C:apoplast; IDA:TAIR.::GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005829; C:cytosol; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005507; F:copper ion binding; IDA:TAIR.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046686; P:response to cadmium ion; IEP:TAIR. | 15 | P28723 | 637 | FTHS_SPIOL Formate--tetrahydrofolate ligase O... | 636 | 0 | 798 | 63 | 77 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 16 | A4J0S6 | 567 | FTHS_DESRM Formate--tetrahydrofolate ligase O... | 631 | 0 | 579 | 49 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 17 | A5UPV2 | 564 | FTHS_ROSS1 Formate--tetrahydrofolate ligase O... | 625 | 0 | 570 | 50 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 18 | A7NGQ9 | 564 | FTHS_ROSCS Formate--tetrahydrofolate ligase O... | 625 | 0 | 551 | 48 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 19 | A4YAP3 | 570 | FTHS_SHEPC Formate--tetrahydrofolate ligase O... | 625 | 0 | 545 | 49 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 20 | Q8EJA7 | 570 | FTHS_SHEON Formate--tetrahydrofolate ligase O... | 626 | 0 | 543 | 48 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 21 | A1RFN3 | 570 | FTHS_SHESW Formate--tetrahydrofolate ligase O... | 625 | 0 | 543 | 49 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 22 | A6WSY9 | 585 | FTHS_SHEB8 Formate--tetrahydrofolate ligase O... | 638 | 1e-179 | 540 | 47 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 23 | A3QA17 | 564 | FTHS_SHELP Formate--tetrahydrofolate ligase O... | 625 | 2e-179 | 539 | 48 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 24 | Q0HMS6 | 570 | FTHS_SHESM Formate--tetrahydrofolate ligase O... | 626 | 4e-179 | 538 | 48 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 25 | A3CZY6 | 585 | FTHS_SHEB5 Formate--tetrahydrofolate ligase O... | 638 | 8e-179 | 538 | 47 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 26 | A0KSN0 | 570 | FTHS_SHESA Formate--tetrahydrofolate ligase O... | 626 | 2e-178 | 536 | 47 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 27 | B1KJC0 | 570 | FTHS_SHEWM Formate--tetrahydrofolate ligase O... | 630 | 6e-178 | 535 | 47 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 28 | B8ECE1 | 580 | FTHS_SHEB2 Formate--tetrahydrofolate ligase O... | 631 | 7e-178 | 535 | 48 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 29 | Q0HR05 | 569 | FTHS_SHESR Formate--tetrahydrofolate ligase O... | 626 | 1e-177 | 534 | 48 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 30 | A9L3Z6 | 585 | FTHS_SHEB9 Formate--tetrahydrofolate ligase O... | 636 | 1e-176 | 532 | 47 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 31 | B7VSJ2 | 582 | FTHS_VIBSL Formate--tetrahydrofolate ligase O... | 631 | 2e-176 | 531 | 46 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. |
