| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
391 | A1Y2K1 | 537 | FYN_PIG Tyrosine-protein kinase Fyn OS=Sus sc... | 283 | 7e-18 | 92.4 | 28 | 49 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 392 | P34152 | 1090 | FAK1_MOUSE Focal adhesion kinase 1 OS=Mus mus... | 287 | 7e-18 | 93.6 | 26 | 46 | GO:0016324; C:apical plasma membrane; IDA:MGI.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:MGI.::GO:0021955; P:central nervous system neuron axonogenesis; IMP:MGI.::GO:0043542; P:endothelial cell migration; IMP:MGI.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0040023; P:establishment of nucleus localization; IDA:MGI.::GO:0030198; P:extracellular matrix organization; IMP:MGI.::GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.::GO:0000226; P:microtubule cytoskeleton organization; IDA:MGI.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0050771; P:negative regulation of axonogenesis; IMP:MGI.::GO:0046621; P:negative regulation of organ growth; IGI:MGI.::GO:0051964; P:negative regulation of synapse assembly; IMP:MGI.::GO:0001764; P:neuron migration; IDA:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.::GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; ISS:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.::GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0045667; P:regulation of osteoblast differentiation; ISS:UniProtKB.::GO:0007172; P:signal complex assembly; IEA:InterPro.::GO:0001570; P:vasculogenesis; IMP:MGI. | 393 | Q63686 | 496 | CDK16_RAT Cyclin-dependent kinase 16 OS=Rattu... | 200 | 7e-18 | 92 | 31 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 394 | A7E3S4 | 648 | RAF1_BOVIN RAF proto-oncogene serine/threonin... | 274 | 7e-18 | 92.8 | 29 | 49 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 395 | Q05397 | 1052 | FAK1_HUMAN Focal adhesion kinase 1 OS=Homo sa... | 287 | 7e-18 | 93.2 | 26 | 46 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008432; F:JUN kinase binding; IDA:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; TAS:UniProtKB.::GO:0007411; P:axon guidance; TAS:UniProtKB.::GO:0048870; P:cell motility; TAS:UniProtKB.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0009790; P:embryo development; TAS:UniProtKB.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0030010; P:establishment of cell polarity; TAS:UniProtKB.::GO:0060396; P:growth hormone receptor signaling pathway; IDA:BHF-UCL.::GO:0003007; P:heart morphogenesis; TAS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; IMP:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0022408; P:negative regulation of cell-cell adhesion; IDA:BHF-UCL.::GO:0038007; P:netrin-activated signaling pathway; TAS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0001890; P:placenta development; TAS:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; TAS:UniProtKB.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:UniProtKB.::GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:UniProtKB.::GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0051493; P:regulation of cytoskeleton organization; TAS:UniProtKB.::GO:0010594; P:regulation of endothelial cell migration; TAS:UniProtKB.::GO:0051893; P:regulation of focal adhesion assembly; TAS:UniProtKB.::GO:0045667; P:regulation of osteoblast differentiation; IMP:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; TAS:UniProtKB.::GO:0007172; P:signal complex assembly; IEA:InterPro. | 396 | Q26614 | 972 | FGFR_STRPU Fibroblast growth factor receptor ... | 306 | 7e-18 | 93.2 | 26 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 397 | Q5R5M7 | 648 | RAF1_PONAB RAF proto-oncogene serine/threonin... | 274 | 8e-18 | 92.4 | 29 | 49 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 398 | P04049 | 648 | RAF1_HUMAN RAF proto-oncogene serine/threonin... | 274 | 8e-18 | 92.4 | 29 | 49 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005741; C:mitochondrial outer membrane; TAS:ProtInc.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:UniProtKB.::GO:0031333; P:negative regulation of protein complex assembly; IDA:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0045595; P:regulation of cell differentiation; TAS:UniProtKB.::GO:2000145; P:regulation of cell motility; TAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; TAS:UniProtKB.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 399 | P15054 | 587 | SRC_AVIS2 Tyrosine-protein kinase transformin... | 288 | 8e-18 | 92.4 | 27 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 400 | P21803 | 821 | FGFR2_MOUSE Fibroblast growth factor receptor... | 307 | 8e-18 | 92.8 | 26 | 45 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0060076; C:excitatory synapse; IMP:UniProtKB.::GO:0005576; C:extracellular region; TAS:MGI.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IDA:MGI.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IEA:InterPro.::GO:0008201; F:heparin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0001525; P:angiogenesis; IGI:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007409; P:axonogenesis; IMP:MGI.::GO:0030282; P:bone mineralization; IMP:MGI.::GO:0060349; P:bone morphogenesis; IMP:MGI.::GO:0060667; P:branch elongation involved in salivary gland morphogenesis; IMP:MGI.::GO:0060670; P:branching involved in embryonic placenta morphogenesis; IMP:MGI.::GO:0048755; P:branching morphogenesis of a nerve; IMP:MGI.::GO:0060449; P:bud elongation involved in lung branching; IMP:MGI.::GO:0045165; P:cell fate commitment; IDA:MGI.::GO:0048557; P:embryonic digestive tract morphogenesis; IMP:MGI.::GO:0009880; P:embryonic pattern specification; IMP:MGI.::GO:0061031; P:endodermal digestive tract morphogenesis; IMP:MGI.::GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IMP:MGI.::GO:0035603; P:fibroblast growth factor receptor signaling pathway involved in hemopoiesis; IMP:UniProtKB.::GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; IMP:MGI.::GO:0035602; P:fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow; IMP:UniProtKB.::GO:0035607; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; IMP:UniProtKB.::GO:0035604; P:fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; IMP:UniProtKB.::GO:0031069; P:hair follicle morphogenesis; IMP:MGI.::GO:0032808; P:lacrimal gland development; IMP:MGI.::GO:0060601; P:lateral sprouting from an epithelium; IMP:MGI.::GO:0070307; P:lens fiber cell development; IGI:MGI.::GO:0060174; P:limb bud formation; IMP:MGI.::GO:0048286; P:lung alveolus development; IMP:MGI.::GO:0060463; P:lung lobe morphogenesis; IMP:MGI.::GO:0060484; P:lung-associated mesenchyme development; IMP:MGI.::GO:0060615; P:mammary gland bud formation; IMP:MGI.::GO:0003149; P:membranous septum morphogenesis; IMP:MGI.::GO:0060915; P:mesenchymal cell differentiation involved in lung development; IGI:MGI.::GO:0060916; P:mesenchymal cell proliferation involved in lung development; IMP:MGI.::GO:0030901; P:midbrain development; IGI:MGI.::GO:0035264; P:multicellular organism growth; IMP:MGI.::GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.::GO:0045839; P:negative regulation of mitosis; IGI:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0007528; P:neuromuscular junction development; IMP:MGI.::GO:0042476; P:odontogenesis; IMP:MGI.::GO:0035265; P:organ growth; IMP:MGI.::GO:0030916; P:otic vesicle formation; IMP:MGI.::GO:0003148; P:outflow tract septum morphogenesis; IMP:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:MGI.::GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IGI:MGI.::GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.::GO:0051781; P:positive regulation of cell division; IMP:MGI.::GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IMP:MGI.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IGI:MGI.::GO:0002053; P:positive regulation of mesenchymal cell proliferation; IGI:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IMP:MGI.::GO:0060523; P:prostate epithelial cord elongation; IMP:MGI.::GO:0021860; P:pyramidal neuron development; IMP:UniProtKB.::GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IMP:MGI.::GO:0010453; P:regulation of cell fate commitment; IMP:MGI.::GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IMP:MGI.::GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.::GO:0051150; P:regulation of smooth muscle cell differentiation; IMP:MGI.::GO:0008589; P:regulation of smoothened signaling pathway; IMP:MGI.::GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; IMP:MGI.::GO:0048489; P:synaptic vesicle transport; IMP:MGI.::GO:0001657; P:ureteric bud development; IGI:MGI.::GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; TAS:DFLAT.::GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:MGI.::GO:0021847; P:ventricular zone neuroblast division; IMP:UniProtKB. | 401 | Q8JG38 | 817 | FGFR2_DANRE Fibroblast growth factor receptor... | 303 | 8e-18 | 92.8 | 26 | 45 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0008284; P:positive regulation of cell proliferation; IEA:InterPro. | 402 | P08941 | 2311 | ROS1_CHICK Proto-oncogene tyrosine-protein ki... | 298 | 8e-18 | 93.6 | 29 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0016049; P:cell growth; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0002066; P:columnar/cuboidal epithelial cell development; ISS:UniProtKB.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0032006; P:regulation of TOR signaling cascade; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. | 403 | O35346 | 1055 | FAK1_RAT Focal adhesion kinase 1 OS=Rattus no... | 287 | 9e-18 | 93.2 | 26 | 46 | GO:0016324; C:apical plasma membrane; IDA:RGD.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IDA:RGD.::GO:0014704; C:intercalated disc; IDA:RGD.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0016604; C:nuclear body; IDA:RGD.::GO:0005730; C:nucleolus; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0042383; C:sarcolemma; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005178; F:integrin binding; IPI:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030644; P:cellular chloride ion homeostasis; IMP:RGD.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0045444; P:fat cell differentiation; IEP:RGD.::GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.::GO:0007254; P:JNK cascade; IMP:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0030336; P:negative regulation of cell migration; IMP:RGD.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0045785; P:positive regulation of cell adhesion; IMP:RGD.::GO:0030307; P:positive regulation of cell growth; IMP:RGD.::GO:0060252; P:positive regulation of glial cell proliferation; IMP:RGD.::GO:0050766; P:positive regulation of phagocytosis; IMP:RGD.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.::GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; ISS:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.::GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.::GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.::GO:0050806; P:positive regulation of synaptic transmission; IMP:RGD.::GO:0045909; P:positive regulation of vasodilation; IMP:RGD.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0045667; P:regulation of osteoblast differentiation; ISS:UniProtKB.::GO:0046685; P:response to arsenic-containing substance; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0032355; P:response to estradiol stimulus; IEP:RGD.::GO:0009749; P:response to glucose stimulus; IEP:RGD.::GO:0009612; P:response to mechanical stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IEP:RGD.::GO:0007172; P:signal complex assembly; IEA:InterPro. | 404 | O35832 | 451 | CKD18_RAT Cyclin-dependent kinase 18 OS=Rattu... | 200 | 9e-18 | 91.3 | 32 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 405 | P24062 | 1370 | IGF1R_RAT Insulin-like growth factor 1 recept... | 302 | 9e-18 | 93.2 | 26 | 47 | GO:0005901; C:caveola; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0043005; C:neuron projection; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0001965; F:G-protein alpha-subunit binding; IPI:RGD.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.::GO:0005010; F:insulin-like growth factor-activated receptor activity; ISS:UniProtKB.::GO:0043548; F:phosphatidylinositol 3-kinase binding; ISS:UniProtKB. | | | | | | | | | | GO:0007409; P:axonogenesis; IMP:RGD.::GO:0030010; P:establishment of cell polarity; IMP:RGD.::GO:0051389; P:inactivation of MAPKK activity; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; IMP:RGD.::GO:0032467; P:positive regulation of cytokinesis; IMP:RGD.::GO:0090031; P:positive regulation of steroid hormone biosynthetic process; IMP:BHF-UCL.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0051262; P:protein tetramerization; ISS:UniProtKB.::GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB.::GO:0033197; P:response to vitamin E; IEP:RGD. | 406 | Q91738 | 1068 | FAK1_XENLA Focal adhesion kinase 1 OS=Xenopus... | 297 | 9e-18 | 92.8 | 27 | 48 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007172; P:signal complex assembly; IEA:InterPro. | 407 | P29321 | 372 | EPHA8_RAT Ephrin type-A receptor 8 OS=Rattus ... | 272 | 9e-18 | 90.1 | 28 | 46 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.::GO:0043005; C:neuron projection; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005004; F:GPI-linked ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; ISS:UniProtKB.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0016322; P:neuron remodeling; ISS:UniProtKB.::GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0006929; P:substrate-dependent cell migration; ISS:UniProtKB. | 408 | P11362 | 822 | FGFR1_HUMAN Fibroblast growth factor receptor... | 310 | 9e-18 | 92.8 | 25 | 45 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; NAS:UniProtKB.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IDA:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:UniProtKB.::GO:0008201; F:heparin binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:ProtInc.::GO:0001764; P:neuron migration; TAS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:UniProtKB.::GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.::GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.::GO:0045666; P:positive regulation of neuron differentiation; IMP:UniProtKB.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; TAS:UniProtKB.::GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0048705; P:skeletal system morphogenesis; TAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 409 | Q25410 | 1607 | MIPR_LYMST Putative molluscan insulin-related... | 292 | 9e-18 | 93.2 | 27 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. | 410 | Q60751 | 1373 | IGF1R_MOUSE Insulin-like growth factor 1 rece... | 303 | 1e-17 | 93.2 | 26 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.::GO:0005010; F:insulin-like growth factor-activated receptor activity; ISS:UniProtKB.::GO:0043548; F:phosphatidylinositol 3-kinase binding; ISS:UniProtKB. | | | | | | | | | | GO:0007420; P:brain development; IMP:MGI.::GO:0031017; P:exocrine pancreas development; IMP:MGI.::GO:0030238; P:male sex determination; IMP:MGI.::GO:0030879; P:mammary gland development; IMP:MGI.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:MGI.::GO:0043410; P:positive regulation of MAPK cascade; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:MGI.::GO:0060740; P:prostate gland epithelium morphogenesis; IMP:MGI.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0051262; P:protein tetramerization; ISS:UniProtKB. | 411 | P16092 | 822 | FGFR1_MOUSE Fibroblast growth factor receptor... | 310 | 1e-17 | 92.4 | 25 | 45 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IPI:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:MGI.::GO:0008201; F:heparin binding; ISS:UniProtKB. | | | | | | | | | | GO:0001525; P:angiogenesis; IGI:MGI.::GO:0060117; P:auditory receptor cell development; IMP:MGI.::GO:0060445; P:branching involved in salivary gland morphogenesis; IMP:MGI.::GO:0048469; P:cell maturation; IMP:MGI.::GO:0002062; P:chondrocyte differentiation; IGI:MGI.::GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.::GO:0035607; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IGI:MGI.::GO:0042472; P:inner ear morphogenesis; IMP:MGI.::GO:0060484; P:lung-associated mesenchyme development; IGI:MGI.::GO:0048762; P:mesenchymal cell differentiation; IGI:MGI.::GO:0030901; P:midbrain development; IMP:MGI.::GO:0042474; P:middle ear morphogenesis; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0001759; P:organ induction; IMP:MGI.::GO:0042473; P:outer ear morphogenesis; IMP:MGI.::GO:0048339; P:paraxial mesoderm development; IGI:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IGI:MGI.::GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.::GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.::GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.::GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; IGI:MGI.::GO:0010863; P:positive regulation of phospholipase C activity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IDA:MGI.::GO:0048378; P:regulation of lateral mesodermal cell fate specification; IGI:MGI.::GO:0007605; P:sensory perception of sound; IMP:MGI.::GO:0001657; P:ureteric bud development; IGI:MGI.::GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; TAS:DFLAT.::GO:0021847; P:ventricular zone neuroblast division; IMP:UniProtKB. | 412 | P00540 | 346 | MOS_HUMAN Proto-oncogene serine/threonine-pro... | 303 | 1e-17 | 89.7 | 27 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 413 | P00524 | 526 | SRC_RSVSA Tyrosine-protein kinase transformin... | 281 | 1e-17 | 91.7 | 27 | 48 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 414 | P00525 | 526 | SRC_AVISR Tyrosine-protein kinase transformin... | 281 | 1e-17 | 91.7 | 27 | 48 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 415 | P13116 | 532 | SRC2_XENLA Tyrosine-protein kinase Src-2 OS=X... | 278 | 1e-17 | 91.7 | 28 | 47 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 416 | P14617 | 1300 | INSRR_CAVPO Insulin receptor-related protein ... | 303 | 1e-17 | 92.8 | 25 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043560; F:insulin receptor substrate binding; IEA:InterPro.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0071469; P:cellular response to alkalinity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. | 417 | P10936 | 537 | YES_XENLA Tyrosine-protein kinase Yes OS=Xeno... | 286 | 1e-17 | 91.7 | 28 | 47 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 418 | P34265 | 437 | KIN31_CAEEL Probable tyrosine-protein kinase ... | 276 | 1e-17 | 90.5 | 30 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 419 | Q00944 | 1053 | FAK1_CHICK Focal adhesion kinase 1 OS=Gallus ... | 287 | 1e-17 | 92.4 | 27 | 46 | GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0007172; P:signal complex assembly; IEA:InterPro. | 420 | Q91286 | 824 | FGFR2_PLEWA Fibroblast growth factor receptor... | 309 | 1e-17 | 92.4 | 26 | 44 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007409; P:axonogenesis; ISS:UniProtKB.::GO:0030282; P:bone mineralization; ISS:UniProtKB.::GO:0060349; P:bone morphogenesis; ISS:UniProtKB.::GO:0060667; P:branch elongation involved in salivary gland morphogenesis; ISS:UniProtKB.::GO:0048755; P:branching morphogenesis of a nerve; ISS:UniProtKB.::GO:0060449; P:bud elongation involved in lung branching; ISS:UniProtKB.::GO:0045165; P:cell fate commitment; ISS:UniProtKB.::GO:0007267; P:cell-cell signaling; ISS:UniProtKB.::GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.::GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.::GO:0048730; P:epidermis morphogenesis; ISS:UniProtKB.::GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; ISS:UniProtKB.::GO:0032808; P:lacrimal gland development; ISS:UniProtKB.::GO:0060601; P:lateral sprouting from an epithelium; ISS:UniProtKB.::GO:0060174; P:limb bud formation; ISS:UniProtKB.::GO:0048286; P:lung alveolus development; ISS:UniProtKB.::GO:0060463; P:lung lobe morphogenesis; ISS:UniProtKB.::GO:0060484; P:lung-associated mesenchyme development; ISS:UniProtKB.::GO:0003149; P:membranous septum morphogenesis; ISS:UniProtKB.::GO:0060915; P:mesenchymal cell differentiation involved in lung development; ISS:UniProtKB.::GO:0060916; P:mesenchymal cell proliferation involved in lung development; ISS:UniProtKB.::GO:0030901; P:midbrain development; ISS:UniProtKB.::GO:0016331; P:morphogenesis of embryonic epithelium; ISS:UniProtKB.::GO:0035264; P:multicellular organism growth; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0042476; P:odontogenesis; ISS:UniProtKB.::GO:0035265; P:organ growth; ISS:UniProtKB.::GO:0030916; P:otic vesicle formation; ISS:UniProtKB.::GO:0003148; P:outflow tract septum morphogenesis; ISS:UniProtKB.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISS:UniProtKB.::GO:0051781; P:positive regulation of cell division; ISS:UniProtKB.::GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0009791; P:post-embryonic development; ISS:UniProtKB.::GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; ISS:UniProtKB.::GO:0060523; P:prostate epithelial cord elongation; ISS:UniProtKB.::GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; ISS:UniProtKB.::GO:0010453; P:regulation of cell fate commitment; ISS:UniProtKB.::GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.::GO:0051150; P:regulation of smooth muscle cell differentiation; ISS:UniProtKB.::GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.::GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; ISS:UniProtKB.::GO:0001657; P:ureteric bud development; ISS:UniProtKB.::GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; ISS:UniProtKB. | 421 | P13115 | 532 | SRC1_XENLA Tyrosine-protein kinase Src-1 OS=X... | 278 | 1e-17 | 91.3 | 28 | 47 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | |
