| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
151 | P93050 | 617 | RKF3_ARATH Probable LRR receptor-like serine/... | 285 | 3e-21 | 103 | 32 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 152 | P54761 | 987 | EPHB4_MOUSE Ephrin type-B receptor 4 OS=Mus m... | 277 | 3e-21 | 103 | 31 | 48 | GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:MGI. | | | | | | | | | | GO:0007155; P:cell adhesion; ISS:UniProtKB.::GO:0002042; P:cell migration involved in sprouting angiogenesis; ISS:UniProtKB.::GO:0003007; P:heart morphogenesis; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 153 | P42679 | 507 | MATK_HUMAN Megakaryocyte-associated tyrosine-... | 264 | 3e-21 | 102 | 30 | 49 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc. | 154 | Q60750 | 977 | EPHA1_MOUSE Ephrin type-A receptor 1 OS=Mus m... | 287 | 5e-21 | 103 | 29 | 47 | GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005005; F:transmembrane-ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; ISS:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.::GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0001954; P:positive regulation of cell-matrix adhesion; ISS:UniProtKB.::GO:0051496; P:positive regulation of stress fiber assembly; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; ISS:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB. | 155 | P08630 | 786 | BTKL_DROME Tyrosine-protein kinase Btk29A OS=... | 275 | 5e-21 | 103 | 28 | 51 | GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0045172; C:germline ring canal; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IMP:FlyBase.::GO:0007349; P:cellularization; IMP:FlyBase.::GO:0007619; P:courtship behavior; NAS:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.::GO:0042023; P:DNA endoreduplication; IMP:FlyBase.::GO:0007391; P:dorsal closure; TAS:FlyBase.::GO:0007301; P:female germline ring canal formation; IDA:UniProtKB.::GO:0008258; P:head involution; IMP:FlyBase.::GO:0007485; P:imaginal disc-derived male genitalia development; IMP:UniProtKB.::GO:0007254; P:JNK cascade; TAS:FlyBase.::GO:0030717; P:karyosome formation; IMP:FlyBase.::GO:0007424; P:open tracheal system development; IMP:FlyBase.::GO:0030723; P:ovarian fusome organization; IMP:FlyBase.::GO:0030833; P:regulation of actin filament polymerization; IMP:FlyBase.::GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.::GO:0046960; P:sensitization; IMP:FlyBase. | 156 | Q07912 | 1038 | ACK1_HUMAN Activated CDC42 kinase 1 OS=Homo s... | 287 | 5e-21 | 103 | 30 | 45 | GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0070436; C:Grb2-EGFR complex; IDA:BHF-UCL.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005154; F:epidermal growth factor receptor binding; IDA:BHF-UCL.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:ProtInc.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IDA:UniProtKB.::GO:0050699; F:WW domain binding; ISS:BHF-UCL. | | | | | | | | | | GO:0007166; P:cell surface receptor signaling pathway; TAS:UniProtKB.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:2000369; P:regulation of clathrin-mediated endocytosis; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:ProtInc. | 157 | Q5U2X5 | 1040 | ACK1_RAT Activated CDC42 kinase 1 OS=Rattus n... | 287 | 5e-21 | 103 | 30 | 45 | GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 158 | Q03526 | 625 | ITK_MOUSE Tyrosine-protein kinase ITK/TSK OS=... | 280 | 6e-21 | 102 | 28 | 50 | GO:0005829; C:cytosol; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; IMP:UniProtKB.::GO:0002250; P:adaptive immune response; IMP:UniProtKB.::GO:0032609; P:interferon-gamma production; IMP:MGI.::GO:0032633; P:interleukin-4 production; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001865; P:NK T cell differentiation; IMP:MGI.::GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB. | 159 | O61460 | 1122 | VAB1_CAEEL Ephrin receptor 1 OS=Caenorhabditi... | 325 | 6e-21 | 103 | 28 | 44 | GO:0030424; C:axon; IDA:WormBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:WormBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; IEA:InterPro.::GO:0019904; F:protein domain specific binding; IPI:WormBase. | | | | | | | | | | GO:0007411; P:axon guidance; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0010172; P:embryonic body morphogenesis; IMP:UniProtKB.::GO:0016331; P:morphogenesis of embryonic epithelium; IMP:UniProtKB.::GO:0060280; P:negative regulation of ovulation; IMP:WormBase.::GO:0001556; P:oocyte maturation; IMP:WormBase.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:WormBase. | 160 | Q86IX1 | 737 | DST1_DICDI Serine/threonine-protein kinase ds... | 263 | 6e-21 | 102 | 30 | 47 | GO:0005737; C:cytoplasm; ISS:dictyBase.::GO:0005634; C:nucleus; ISS:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:dictyBase. | | | | | | | | | | GO:0006915; P:apoptotic process; ISS:dictyBase.::GO:0008283; P:cell proliferation; ISS:dictyBase.::GO:0007165; P:signal transduction; ISS:dictyBase. | 161 | P42689 | 334 | SRK3_SPOLA Tyrosine-protein kinase SRK3 OS=Sp... | 283 | 6e-21 | 99.8 | 28 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 162 | Q5E9L6 | 487 | STK4_BOVIN Serine/threonine-protein kinase 4 ... | 267 | 7e-21 | 101 | 30 | 48 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0035329; P:hippo signaling cascade; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB. | 163 | Q802A6 | 491 | STK4_SQUAC Serine/threonine-protein kinase 3/... | 267 | 7e-21 | 101 | 30 | 47 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0035329; P:hippo signaling cascade; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB. | 164 | Q07014 | 512 | LYN_RAT Tyrosine-protein kinase Lyn OS=Rattus... | 266 | 7e-21 | 101 | 27 | 50 | GO:0034666; C:alpha2-beta1 integrin complex; IDA:RGD.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0030061; C:mitochondrial crista; IDA:RGD.::GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043208; F:glycosphingolipid binding; IPI:RGD.::GO:0005178; F:integrin binding; IDA:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0051219; F:phosphoprotein binding; IPI:RGD.::GO:0005161; F:platelet-derived growth factor receptor binding; IPI:RGD.::GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD. | | | | | | | | | | GO:0001782; P:B cell homeostasis; ISS:UniProtKB.::GO:0034605; P:cellular response to heat; IEP:RGD.::GO:0050663; P:cytokine secretion; IMP:RGD.::GO:0097028; P:dendritic cell differentiation; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; ISS:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB.::GO:0002553; P:histamine secretion by mast cell; IMP:RGD.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; ISS:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; ISS:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; IEP:RGD.::GO:0002576; P:platelet degranulation; ISS:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; ISS:UniProtKB.::GO:0060369; P:positive regulation of Fc receptor mediated stimulatory signaling pathway; IMP:RGD.::GO:0060252; P:positive regulation of glial cell proliferation; IDA:RGD.::GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; IMP:RGD.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; ISS:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IMP:RGD.::GO:0043200; P:response to amino acid stimulus; IEP:RGD.::GO:0048678; P:response to axon injury; IEP:RGD.::GO:0009743; P:response to carbohydrate stimulus; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0032868; P:response to insulin stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0006991; P:response to sterol depletion; IEP:RGD.::GO:0009636; P:response to toxin; IEP:RGD.::GO:0002513; P:tolerance induction to self antigen; ISS:UniProtKB. | 165 | Q54RB7 | 527 | SHKA_DICDI Dual specificity protein kinase sh... | 271 | 7e-21 | 101 | 30 | 50 | GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051219; F:phosphoprotein binding; ISS:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IDA:dictyBase.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0009968; P:negative regulation of signal transduction; IMP:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase. | 166 | P54763 | 994 | EPHB2_MOUSE Ephrin type-B receptor 2 OS=Mus m... | 286 | 7e-21 | 102 | 30 | 48 | GO:0030424; C:axon; IDA:UniProtKB.::GO:0030425; C:dendrite; IDA:UniProtKB.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.::GO:0045202; C:synapse; NAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005005; F:transmembrane-ephrin receptor activity; IDA:UniProtKB. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:UniProtKB.::GO:0007413; P:axonal fasciculation; IMP:UniProtKB.::GO:0071679; P:commissural neuron axon guidance; IMP:UniProtKB.::GO:0022038; P:corpus callosum development; IMP:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; IMP:UniProtKB.::GO:0042472; P:inner ear morphogenesis; IMP:UniProtKB.::GO:0060021; P:palate development; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0051965; P:positive regulation of synapse assembly; IDA:UniProtKB.::GO:0050878; P:regulation of body fluid levels; IMP:UniProtKB.::GO:0001655; P:urogenital system development; IMP:UniProtKB. | 167 | O54748 | 491 | STK3_RAT Serine/threonine-protein kinase 3 OS... | 266 | 9e-21 | 100 | 30 | 47 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0035329; P:hippo signaling cascade; ISS:UniProtKB. | 168 | Q90330 | 713 | FGFR4_COTCO Fibroblast growth factor receptor... | 323 | 9e-21 | 102 | 28 | 46 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0008284; P:positive regulation of cell proliferation; IEA:InterPro. | 169 | Q60805 | 994 | MERTK_MOUSE Tyrosine-protein kinase Mer OS=Mu... | 311 | 9e-21 | 102 | 29 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0043277; P:apoptotic cell clearance; IMP:UniProtKB.::GO:0030168; P:platelet activation; IMP:MGI.::GO:0043491; P:protein kinase B signaling cascade; IGI:MGI.::GO:0060041; P:retina development in camera-type eye; IMP:MGI.::GO:0032940; P:secretion by cell; IMP:MGI.::GO:0034446; P:substrate adhesion-dependent cell spreading; IMP:MGI. | 170 | P42690 | 506 | SRK4_SPOLA Tyrosine-protein kinase isoform SR... | 281 | 9e-21 | 100 | 26 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 171 | Q8S8Y8 | 567 | WNK6_ARATH Probable serine/threonine-protein ... | 248 | 1e-20 | 101 | 32 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 172 | Q1KL86 | 976 | EPHA2_MACFA Ephrin type-A receptor 2 OS=Macac... | 285 | 1e-20 | 102 | 27 | 48 | GO:0005925; C:focal adhesion; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; ISS:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046849; P:bone remodeling; ISS:UniProtKB.::GO:0060444; P:branching involved in mammary gland duct morphogenesis; ISS:UniProtKB.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0060326; P:cell chemotaxis; ISS:UniProtKB.::GO:0070309; P:lens fiber cell morphogenesis; ISS:UniProtKB.::GO:0033598; P:mammary gland epithelial cell proliferation; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; ISS:UniProtKB.::GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.::GO:0030316; P:osteoclast differentiation; ISS:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:UniProtKB.::GO:0043491; P:protein kinase B signaling cascade; ISS:UniProtKB.::GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0010591; P:regulation of lamellipodium assembly; ISS:UniProtKB.::GO:0070848; P:response to growth factor stimulus; ISS:UniProtKB. | 173 | Q9Z1J2 | 792 | NEK4_MOUSE Serine/threonine-protein kinase Ne... | 283 | 1e-20 | 102 | 26 | 48 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 174 | P29317 | 976 | EPHA2_HUMAN Ephrin type-A receptor 2 OS=Homo ... | 285 | 1e-20 | 102 | 27 | 48 | GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; IMP:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; IDA:UniProtKB.::GO:0046849; P:bone remodeling; ISS:UniProtKB.::GO:0060444; P:branching involved in mammary gland duct morphogenesis; ISS:UniProtKB.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0060326; P:cell chemotaxis; IMP:UniProtKB.::GO:0030216; P:keratinocyte differentiation; IMP:UniProtKB.::GO:0070309; P:lens fiber cell morphogenesis; ISS:UniProtKB.::GO:0033598; P:mammary gland epithelial cell proliferation; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IDA:UniProtKB.::GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.::GO:0030316; P:osteoclast differentiation; ISS:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:UniProtKB.::GO:0043491; P:protein kinase B signaling cascade; IDA:UniProtKB.::GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.::GO:0043535; P:regulation of blood vessel endothelial cell migration; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IDA:UniProtKB.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0010591; P:regulation of lamellipodium assembly; IMP:UniProtKB.::GO:0070848; P:response to growth factor stimulus; IMP:UniProtKB. | 175 | P28693 | 1004 | EPHB2_CHICK Ephrin type-B receptor 2 OS=Gallu... | 286 | 1e-20 | 102 | 29 | 48 | GO:0030424; C:axon; ISS:UniProtKB.::GO:0030425; C:dendrite; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005005; F:transmembrane-ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0007411; P:axon guidance; ISS:UniProtKB.::GO:0007413; P:axonal fasciculation; ISS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB. | 176 | P32577 | 450 | CSK_RAT Tyrosine-protein kinase CSK OS=Rattus... | 273 | 1e-20 | 100 | 28 | 49 | GO:0045121; C:membrane raft; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0070064; F:proline-rich region binding; IPI:BHF-UCL.::GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL. | | | | | | | | | | GO:0034332; P:adherens junction organization; IEP:RGD.::GO:0007420; P:brain development; IEP:RGD.::GO:0071375; P:cellular response to peptide hormone stimulus; IDA:RGD.::GO:0045779; P:negative regulation of bone resorption; IDA:RGD.::GO:0008285; P:negative regulation of cell proliferation; IDA:RGD.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:RGD.::GO:0032715; P:negative regulation of interleukin-6 production; IDA:RGD.::GO:0033673; P:negative regulation of kinase activity; IDA:RGD.::GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IDA:RGD.::GO:0050765; P:negative regulation of phagocytosis; IDA:RGD.::GO:0048709; P:oligodendrocyte differentiation; IEP:RGD.::GO:0043406; P:positive regulation of MAP kinase activity; IDA:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0060368; P:regulation of Fc receptor mediated stimulatory signaling pathway; IDA:RGD. | 177 | Q9JI11 | 487 | STK4_MOUSE Serine/threonine-protein kinase 4 ... | 269 | 1e-20 | 100 | 31 | 48 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0060706; P:cell differentiation involved in embryonic placenta development; IGI:MGI.::GO:0007417; P:central nervous system development; IGI:MGI.::GO:0003157; P:endocardium development; IGI:MGI.::GO:0035329; P:hippo signaling cascade; IMP:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IGI:MGI.::GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.::GO:0046621; P:negative regulation of organ growth; IGI:MGI.::GO:0001841; P:neural tube formation; IGI:MGI.::GO:0001569; P:patterning of blood vessels; IGI:MGI.::GO:0060215; P:primitive hemopoiesis; IGI:MGI. | 178 | Q03142 | 799 | FGFR4_MOUSE Fibroblast growth factor receptor... | 321 | 1e-20 | 101 | 28 | 45 | GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; ISS:UniProtKB.::GO:0008201; F:heparin binding; ISS:UniProtKB. | | | | | | | | | | GO:0061144; P:alveolar secondary septum development; IGI:MGI.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; IMP:UniProtKB.::GO:0001759; P:organ induction; IMP:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0055062; P:phosphate ion homeostasis; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0048554; P:positive regulation of metalloenzyme activity; ISS:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; IMP:UniProtKB.::GO:2000188; P:regulation of cholesterol homeostasis; IMP:UniProtKB.::GO:0010715; P:regulation of extracellular matrix disassembly; ISS:UniProtKB. | 179 | A4K2M3 | 487 | STK4_PAPAN Serine/threonine-protein kinase 4 ... | 269 | 2e-20 | 100 | 31 | 48 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0035329; P:hippo signaling cascade; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB. | 180 | Q08881 | 620 | ITK_HUMAN Tyrosine-protein kinase ITK/TSK OS=... | 280 | 2e-20 | 100 | 28 | 50 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; ISS:UniProtKB.::GO:0002250; P:adaptive immune response; ISS:UniProtKB.::GO:0006968; P:cellular defense response; TAS:ProtInc.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. | 181 | Q556S2 | 513 | PAKH_DICDI Serine/threonine-protein kinase pa... | 281 | 2e-20 | 100 | 31 | 50 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:dictyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:dictyBase. | | | | | | | | | | |
