| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
121 | Q06187 | 659 | BTK_HUMAN Tyrosine-protein kinase BTK OS=Homo... | 285 | 2e-22 | 107 | 27 | 52 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:HGNC.::GO:0005634; C:nucleus; TAS:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; TAS:HGNC.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:UniProtKB.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB. | | | | | | | | | | GO:0002250; P:adaptive immune response; TAS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042113; P:B cell activation; TAS:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; TAS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; TAS:HGNC.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:UniProtKB.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0045579; P:positive regulation of B cell differentiation; TAS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:UniProtKB.::GO:0002902; P:regulation of B cell apoptotic process; TAS:UniProtKB.::GO:0002721; P:regulation of B cell cytokine production; TAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 122 | Q91571 | 985 | EPB1A_XENLA Ephrin type-B receptor 1-A OS=Xen... | 276 | 2e-22 | 107 | 31 | 49 | GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.::GO:0031901; C:early endosome membrane; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005005; F:transmembrane-ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; ISS:UniProtKB.::GO:0060326; P:cell chemotaxis; ISS:UniProtKB.::GO:0031589; P:cell-substrate adhesion; ISS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB.::GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB. | 123 | P24604 | 630 | TEC_MOUSE Tyrosine-protein kinase Tec OS=Mus ... | 281 | 2e-22 | 106 | 28 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 124 | Q2QXC6 | 417 | WNK9_ORYSJ Probable serine/threonine-protein ... | 199 | 3e-22 | 104 | 38 | 52 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 125 | Q91736 | 902 | EPB1B_XENLA Ephrin type-B receptor 1-B OS=Xen... | 276 | 3e-22 | 107 | 31 | 49 | GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.::GO:0031901; C:early endosome membrane; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005005; F:transmembrane-ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; ISS:UniProtKB.::GO:0060326; P:cell chemotaxis; ISS:UniProtKB.::GO:0031589; P:cell-substrate adhesion; ISS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB.::GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB. | 126 | P21709 | 976 | EPHA1_HUMAN Ephrin type-A receptor 1 OS=Homo ... | 288 | 3e-22 | 107 | 29 | 47 | GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0005005; F:transmembrane-ephrin receptor activity; IDA:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; IDA:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.::GO:0006469; P:negative regulation of protein kinase activity; IDA:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0045766; P:positive regulation of angiogenesis; IMP:UniProtKB.::GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0001954; P:positive regulation of cell-matrix adhesion; IDA:UniProtKB.::GO:0051496; P:positive regulation of stress fiber assembly; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; IDA:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; IDA:UniProtKB. | 127 | P16591 | 822 | FER_HUMAN Tyrosine-protein kinase Fer OS=Homo... | 268 | 4e-22 | 106 | 30 | 51 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.::GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005154; F:epidermal growth factor receptor binding; IDA:UniProtKB.::GO:0008289; F:lipid binding; IDA:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0008283; P:cell proliferation; IMP:UniProtKB.::GO:0044331; P:cell-cell adhesion mediated by cadherin; ISS:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IMP:UniProtKB.::GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.::GO:0050904; P:diapedesis; ISS:UniProtKB.::GO:0035426; P:extracellular matrix-cell signaling; ISS:UniProtKB.::GO:0038095; P:Fc-epsilon receptor signaling pathway; ISS:UniProtKB.::GO:0038028; P:insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.::GO:0070102; P:interleukin-6-mediated signaling pathway; IMP:UniProtKB.::GO:0038109; P:Kit signaling pathway; ISS:UniProtKB.::GO:0000226; P:microtubule cytoskeleton organization; IMP:UniProtKB.::GO:0000278; P:mitotic cell cycle; IMP:UniProtKB.::GO:0033007; P:negative regulation of mast cell activation involved in immune response; ISS:UniProtKB.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; IMP:UniProtKB.::GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; TAS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; IMP:UniProtKB.::GO:0010591; P:regulation of lamellipodium assembly; IDA:UniProtKB.::GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.::GO:0036119; P:response to platelet-derived growth factor stimulus; ISS:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB.::GO:0042503; P:tyrosine phosphorylation of Stat3 protein; IDA:UniProtKB. | 128 | P09760 | 823 | FER_RAT Tyrosine-protein kinase Fer OS=Rattus... | 268 | 5e-22 | 106 | 30 | 51 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IPI:RGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0045296; F:cadherin binding; IPI:RGD.::GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0045295; F:gamma-catenin binding; IPI:RGD.::GO:0008289; F:lipid binding; ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0017137; F:Rab GTPase binding; IPI:RGD. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0044331; P:cell-cell adhesion mediated by cadherin; ISS:UniProtKB.::GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.::GO:0050904; P:diapedesis; ISS:UniProtKB.::GO:0035426; P:extracellular matrix-cell signaling; ISS:UniProtKB.::GO:0038095; P:Fc-epsilon receptor signaling pathway; ISS:UniProtKB.::GO:0038028; P:insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.::GO:0038109; P:Kit signaling pathway; ISS:UniProtKB.::GO:0000226; P:microtubule cytoskeleton organization; ISS:UniProtKB.::GO:0033007; P:negative regulation of mast cell activation involved in immune response; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0010591; P:regulation of lamellipodium assembly; ISS:UniProtKB.::GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.::GO:0036119; P:response to platelet-derived growth factor stimulus; ISS:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB. | 129 | Q9TTY2 | 823 | FER_CANFA Tyrosine-protein kinase Fer OS=Cani... | 268 | 5e-22 | 106 | 29 | 50 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 130 | P70451 | 823 | FER_MOUSE Tyrosine-protein kinase Fer OS=Mus ... | 268 | 6e-22 | 106 | 30 | 51 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0008289; F:lipid binding; ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.::GO:0008157; F:protein phosphatase 1 binding; IPI:UniProtKB. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB.::GO:0044331; P:cell-cell adhesion mediated by cadherin; IMP:UniProtKB.::GO:0034614; P:cellular response to reactive oxygen species; IMP:UniProtKB.::GO:0006935; P:chemotaxis; IMP:MGI.::GO:0050904; P:diapedesis; IMP:UniProtKB.::GO:0035426; P:extracellular matrix-cell signaling; IMP:UniProtKB.::GO:0038095; P:Fc-epsilon receptor signaling pathway; IMP:UniProtKB.::GO:0038028; P:insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; IDA:UniProtKB.::GO:0038109; P:Kit signaling pathway; IMP:UniProtKB.::GO:0000226; P:microtubule cytoskeleton organization; ISS:UniProtKB.::GO:0033007; P:negative regulation of mast cell activation involved in immune response; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0010762; P:regulation of fibroblast migration; IMP:UniProtKB.::GO:0010591; P:regulation of lamellipodium assembly; ISS:UniProtKB.::GO:0001932; P:regulation of protein phosphorylation; IMP:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; IMP:UniProtKB.::GO:0036119; P:response to platelet-derived growth factor stimulus; IDA:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; IMP:UniProtKB. | 131 | Q07498 | 988 | EPHB3_CHICK Ephrin type-B receptor 3 OS=Gallu... | 281 | 8e-22 | 106 | 30 | 48 | GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007413; P:axonal fasciculation; ISS:UniProtKB.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB.::GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0050770; P:regulation of axonogenesis; ISS:UniProtKB.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0022407; P:regulation of cell-cell adhesion; ISS:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; ISS:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB. | 132 | Q8LST2 | 557 | WNK7_ARATH Probable serine/threonine-protein ... | 248 | 8e-22 | 104 | 33 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 133 | P42681 | 527 | TXK_HUMAN Tyrosine-protein kinase TXK OS=Homo... | 285 | 8e-22 | 104 | 29 | 51 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:ProtInc.::GO:0001012; F:RNA polymerase II regulatory region DNA binding; IDA:UniProtKB. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; ISS:UniProtKB.::GO:0002250; P:adaptive immune response; ISS:UniProtKB.::GO:0032729; P:positive regulation of interferon-gamma production; IDA:UniProtKB.::GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 134 | Q55EC7 | 960 | GEFX_DICDI RasGEF domain-containing serine/th... | 279 | 8e-22 | 105 | 30 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 135 | O13147 | 500 | EPHB3_DANRE Ephrin type-B receptor 3 OS=Danio... | 292 | 9e-22 | 103 | 30 | 47 | GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; ISS:UniProtKB.::GO:0007413; P:axonal fasciculation; ISS:UniProtKB.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB.::GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0050770; P:regulation of axonogenesis; ISS:UniProtKB.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0022407; P:regulation of cell-cell adhesion; ISS:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; ISS:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB. | 136 | P09208 | 2144 | INSR_DROME Insulin-like receptor OS=Drosophil... | 308 | 1e-21 | 106 | 27 | 43 | GO:0005911; C:cell-cell junction; IDA:FlyBase.::GO:0005899; C:insulin receptor complex; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IC:FlyBase.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0043559; F:insulin binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.::GO:0005009; F:insulin-activated receptor activity; IDA:FlyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0043548; F:phosphatidylinositol 3-kinase binding; ISS:UniProtKB.::GO:0051425; F:PTB domain binding; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007411; P:axon guidance; IMP:UniProtKB.::GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.::GO:0007391; P:dorsal closure; TAS:FlyBase.::GO:0048132; P:female germ-line stem cell division; IMP:FlyBase.::GO:0060180; P:female mating behavior; IMP:FlyBase.::GO:0007390; P:germ-band shortening; IGI:FlyBase.::GO:0060250; P:germ-line stem-cell niche homeostasis; IMP:FlyBase.::GO:0007446; P:imaginal disc growth; IMP:FlyBase.::GO:0007626; P:locomotory behavior; IMP:FlyBase.::GO:0048133; P:male germ-line stem cell division; IMP:FlyBase.::GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0045793; P:positive regulation of cell size; NAS:FlyBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:UniProtKB.::GO:0046622; P:positive regulation of organ growth; IMP:UniProtKB.::GO:0007285; P:primary spermatocyte growth; IMP:FlyBase.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0051290; P:protein heterotetramerization; ISS:UniProtKB.::GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:FlyBase.::GO:0034059; P:response to anoxia; IDA:FlyBase.::GO:0042220; P:response to cocaine; IGI:FlyBase.::GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.::GO:0007584; P:response to nutrient; TAS:FlyBase.::GO:0007296; P:vitellogenesis; TAS:FlyBase. | 137 | P42683 | 508 | LCK_CHICK Proto-oncogene tyrosine-protein kin... | 282 | 1e-21 | 103 | 28 | 51 | GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB. | 138 | P00528 | 552 | SRC64_DROME Tyrosine-protein kinase Src64B OS... | 275 | 1e-21 | 103 | 30 | 49 | GO:0045172; C:germline ring canal; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0007349; P:cellularization; IMP:FlyBase.::GO:0007391; P:dorsal closure; TAS:FlyBase.::GO:0008302; P:female germline ring canal formation, actin assembly; IMP:FlyBase.::GO:0008335; P:female germline ring canal stabilization; IMP:FlyBase.::GO:0030708; P:germarium-derived female germ-line cyst encapsulation; IMP:FlyBase.::GO:0007254; P:JNK cascade; TAS:FlyBase.::GO:0030717; P:karyosome formation; IMP:FlyBase.::GO:0016319; P:mushroom body development; IMP:FlyBase.::GO:0008355; P:olfactory learning; IMP:FlyBase.::GO:0030723; P:ovarian fusome organization; IMP:FlyBase.::GO:0030046; P:parallel actin filament bundle assembly; IMP:FlyBase.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IGI:FlyBase.::GO:0008064; P:regulation of actin polymerization or depolymerization; IMP:FlyBase.::GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase. | 139 | P36894 | 532 | BMR1A_HUMAN Bone morphogenetic protein recept... | 303 | 2e-21 | 103 | 29 | 46 | GO:0016021; C:integral to membrane; TAS:ProtInc.::GO:0005886; C:plasma membrane; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:HGNC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.::GO:0046332; F:SMAD binding; IDA:HGNC.::GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.::GO:0006955; P:immune response; IMP:BHF-UCL.::GO:0030501; P:positive regulation of bone mineralization; IMP:BHF-UCL.::GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL.::GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.::GO:0060391; P:positive regulation of SMAD protein import into nucleus; IDA:BHF-UCL.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc. | 140 | Q01621 | 509 | LCK_RAT Proto-oncogene tyrosine-protein kinas... | 274 | 2e-21 | 103 | 28 | 50 | GO:0030139; C:endocytic vesicle; IDA:RGD.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0003823; F:antigen binding; IPI:RGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0032403; F:protein complex binding; IDA:RGD. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0006915; P:apoptotic process; IEP:RGD.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.::GO:0070474; P:positive regulation of uterine smooth muscle contraction; IMP:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0042542; P:response to hydrogen peroxide; IDA:RGD.::GO:0009612; P:response to mechanical stimulus; IMP:RGD.::GO:0010043; P:response to zinc ion; IEP:RGD. | 141 | P36895 | 532 | BMR1A_MOUSE Bone morphogenetic protein recept... | 303 | 2e-21 | 103 | 29 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI.::GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; IDA:MGI.::GO:0051216; P:cartilage development; IMP:MGI.::GO:0048589; P:developmental growth; IMP:MGI.::GO:0009950; P:dorsal/ventral axis specification; IMP:MGI.::GO:0007398; P:ectoderm development; IMP:MGI.::GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.::GO:0048568; P:embryonic organ development; IMP:MGI.::GO:0003272; P:endocardial cushion formation; IMP:MGI.::GO:0060914; P:heart formation; IMP:MGI.::GO:0035137; P:hindlimb morphogenesis; IMP:MGI.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0048368; P:lateral mesoderm development; IMP:MGI.::GO:0030324; P:lung development; IMP:MGI.::GO:0048382; P:mesendoderm development; IMP:MGI.::GO:0001707; P:mesoderm formation; IMP:MGI.::GO:0001880; P:Mullerian duct regression; IMP:MGI.::GO:0050768; P:negative regulation of neurogenesis; IMP:MGI.::GO:0014032; P:neural crest cell development; IMP:MGI.::GO:0021998; P:neural plate mediolateral regionalization; IMP:MGI.::GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.::GO:0060021; P:palate development; IMP:MGI.::GO:0048352; P:paraxial mesoderm structural organization; IMP:MGI.::GO:0021983; P:pituitary gland development; IMP:MGI.::GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:MGI.::GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.::GO:0048378; P:regulation of lateral mesodermal cell fate specification; IGI:MGI.::GO:0001756; P:somitogenesis; IMP:MGI.::GO:0019827; P:stem cell maintenance; IMP:MGI. | 142 | Q78EA7 | 532 | BMR1A_RAT Bone morphogenetic protein receptor... | 303 | 2e-21 | 103 | 29 | 46 | GO:0030425; C:dendrite; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0043025; C:neuronal cell body; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro. | | | | | | | | | | | 143 | Q03145 | 977 | EPHA2_MOUSE Ephrin type-A receptor 2 OS=Mus m... | 285 | 2e-21 | 104 | 27 | 48 | GO:0005925; C:focal adhesion; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; ISS:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048320; P:axial mesoderm formation; IMP:MGI.::GO:0046849; P:bone remodeling; IMP:UniProtKB.::GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:UniProtKB.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0060326; P:cell chemotaxis; ISS:UniProtKB.::GO:0070309; P:lens fiber cell morphogenesis; IDA:UniProtKB.::GO:0033598; P:mammary gland epithelial cell proliferation; IMP:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; ISS:UniProtKB.::GO:0021915; P:neural tube development; IMP:MGI.::GO:0030182; P:neuron differentiation; IDA:MGI.::GO:0060035; P:notochord cell development; IMP:MGI.::GO:0014028; P:notochord formation; IMP:MGI.::GO:0001649; P:osteoblast differentiation; IMP:UniProtKB.::GO:0030316; P:osteoclast differentiation; IDA:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:UniProtKB.::GO:0043491; P:protein kinase B signaling cascade; ISS:UniProtKB.::GO:0045765; P:regulation of angiogenesis; IDA:UniProtKB.::GO:0043535; P:regulation of blood vessel endothelial cell migration; IDA:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0010591; P:regulation of lamellipodium assembly; ISS:UniProtKB.::GO:0070848; P:response to growth factor stimulus; ISS:UniProtKB.::GO:0001501; P:skeletal system development; IMP:MGI.::GO:0035121; P:tail morphogenesis; IMP:MGI.::GO:0001570; P:vasculogenesis; IMP:MGI. | 144 | P29323 | 1055 | EPHB2_HUMAN Ephrin type-B receptor 2 OS=Homo ... | 286 | 2e-21 | 104 | 30 | 48 | GO:0030424; C:axon; ISS:UniProtKB.::GO:0030425; C:dendrite; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005005; F:transmembrane-ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0007413; P:axonal fasciculation; ISS:UniProtKB.::GO:0071679; P:commissural neuron axon guidance; ISS:UniProtKB.::GO:0022038; P:corpus callosum development; ISS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB.::GO:0042472; P:inner ear morphogenesis; ISS:UniProtKB.::GO:0060021; P:palate development; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.::GO:0050878; P:regulation of body fluid levels; ISS:UniProtKB.::GO:0001655; P:urogenital system development; ISS:UniProtKB. | 145 | P06240 | 509 | LCK_MOUSE Proto-oncogene tyrosine-protein kin... | 274 | 2e-21 | 103 | 28 | 50 | GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; IDA:MGI.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IMP:MGI.::GO:0010628; P:positive regulation of gene expression; IDA:MGI.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IDA:MGI.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0050856; P:regulation of T cell receptor signaling pathway; IDA:MGI.::GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB. | 146 | P06239 | 509 | LCK_HUMAN Tyrosine-protein kinase Lck OS=Homo... | 285 | 2e-21 | 103 | 28 | 49 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0045121; C:membrane raft; IDA:UniProtKB.::GO:0000242; C:pericentriolar material; IDA:UniProtKB.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051117; F:ATPase binding; IPI:UniProtKB.::GO:0042609; F:CD4 receptor binding; IPI:UniProtKB.::GO:0042610; F:CD8 receptor binding; IPI:UniProtKB.::GO:0001948; F:glycoprotein binding; IPI:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:UniProtKB.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; IEP:UniProtKB.::GO:0006917; P:induction of apoptosis; IMP:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0050862; P:positive regulation of T cell receptor signaling pathway; NAS:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.::GO:0042493; P:response to drug; IDA:UniProtKB.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0030217; P:T cell differentiation; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome. | 147 | P22455 | 802 | FGFR4_HUMAN Fibroblast growth factor receptor... | 319 | 2e-21 | 104 | 28 | 44 | GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IDA:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:UniProtKB.::GO:0008201; F:heparin binding; IDA:UniProtKB. | | | | | | | | | | GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0055062; P:phosphate ion homeostasis; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.::GO:2000573; P:positive regulation of DNA biosynthetic process; IMP:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0048554; P:positive regulation of metalloenzyme activity; IMP:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; IMP:UniProtKB.::GO:2000188; P:regulation of cholesterol homeostasis; ISS:UniProtKB.::GO:0010715; P:regulation of extracellular matrix disassembly; IMP:UniProtKB. | 148 | P54760 | 987 | EPHB4_HUMAN Ephrin type-B receptor 4 OS=Homo ... | 277 | 2e-21 | 104 | 31 | 48 | GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007155; P:cell adhesion; IDA:UniProtKB.::GO:0002042; P:cell migration involved in sprouting angiogenesis; IDA:UniProtKB.::GO:0003007; P:heart morphogenesis; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB. | 149 | P51957 | 841 | NEK4_HUMAN Serine/threonine-protein kinase Ne... | 283 | 2e-21 | 104 | 26 | 48 | GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 150 | O54967 | 1055 | ACK1_MOUSE Activated CDC42 kinase 1 OS=Mus mu... | 287 | 3e-21 | 104 | 30 | 45 | GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0030424; C:axon; IDA:MGI.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IDA:MGI.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0030426; C:growth cone; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0050699; F:WW domain binding; IPI:BHF-UCL. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 151 | P93050 | 617 | RKF3_ARATH Probable LRR receptor-like serine/... | 285 | 3e-21 | 103 | 32 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW. | | | | | | | | | | |
