| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
91 | O14408 | 382 | KCC1_METAN Calcium/calmodulin-dependent prote... | 122 | 0.046 | 42 | 27 | 44 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 92 | Q91819 | 408 | AURAB_XENLA Aurora kinase A-B OS=Xenopus laev... | 148 | 0.052 | 41.6 | 28 | 45 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0005876; C:spindle microtubule; ISS:UniProtKB.::GO:0000922; C:spindle pole; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019894; F:kinesin binding; ISS:UniProtKB.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0018105; P:peptidyl-serine phosphorylation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0090307; P:spindle assembly involved in mitosis; ISS:UniProtKB. | 93 | Q91820 | 407 | AURAA_XENLA Aurora kinase A-A OS=Xenopus laev... | 148 | 0.053 | 41.6 | 29 | 44 | GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005876; C:spindle microtubule; IDA:UniProtKB.::GO:0000922; C:spindle pole; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019894; F:kinesin binding; IPI:UniProtKB.::GO:0008017; F:microtubule binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0018105; P:peptidyl-serine phosphorylation; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IMP:UniProtKB.::GO:0090307; P:spindle assembly involved in mitosis; IMP:UniProtKB. | 94 | Q9D2Y4 | 472 | MLKL_MOUSE Mixed lineage kinase domain-like p... | 182 | 0.055 | 41.6 | 23 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:InterPro.::GO:0004672; F:protein kinase activity; IEA:InterPro. | | | | | | | | | | | 95 | Q6XUX0 | 930 | DUSTY_CHICK Dual serine/threonine and tyrosin... | 123 | 0.059 | 42 | 24 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 96 | O70126 | 345 | AURKB_MOUSE Aurora kinase B OS=Mus musculus (... | 169 | 0.059 | 41.6 | 26 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071777; P:positive regulation of cell cycle cytokinesis; ISS:UniProtKB.::GO:0034501; P:protein localization to kinetochore; ISS:UniProtKB.::GO:0051256; P:spindle midzone assembly involved in mitosis; ISS:UniProtKB. | 97 | Q54RB7 | 527 | SHKA_DICDI Dual specificity protein kinase sh... | 98 | 0.06 | 41.6 | 24 | 51 | GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051219; F:phosphoprotein binding; ISS:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IDA:dictyBase.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0009968; P:negative regulation of signal transduction; IMP:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase. | 98 | Q12706 | 436 | PSK1_SCHPO Serine/threonine-protein kinase ps... | 168 | 0.065 | 41.6 | 29 | 45 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | GO:0007165; P:signal transduction; IC:PomBase. | 99 | Q07832 | 603 | PLK1_MOUSE Serine/threonine-protein kinase PL... | 155 | 0.067 | 41.6 | 23 | 48 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0030496; C:midbody; ISS:UniProtKB.::GO:0051233; C:spindle midzone; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007092; P:activation of mitotic anaphase-promoting complex activity; ISS:UniProtKB.::GO:0051297; P:centrosome organization; ISS:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.::GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0071168; P:protein localization to chromatin; ISS:UniProtKB. | 100 | Q96GD4 | 344 | AURKB_HUMAN Aurora kinase B OS=Homo sapiens (... | 101 | 0.067 | 41.2 | 32 | 50 | GO:0032133; C:chromosome passenger complex; IPI:UniProtKB.::GO:0000780; C:condensed nuclear chromosome, centromeric region; IDA:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030496; C:midbody; TAS:UniProtKB.::GO:0005819; C:spindle; TAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; TAS:UniProtKB. | | | | | | | | | | GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0008608; P:attachment of spindle microtubules to kinetochore; TAS:UniProtKB.::GO:0034644; P:cellular response to UV; IDA:UniProtKB.::GO:0016570; P:histone modification; TAS:UniProtKB.::GO:0000236; P:mitotic prometaphase; TAS:Reactome.::GO:0002903; P:negative regulation of B cell apoptotic process; IDA:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0071777; P:positive regulation of cell cycle cytokinesis; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.::GO:0034501; P:protein localization to kinetochore; IMP:UniProtKB.::GO:0051983; P:regulation of chromosome segregation; TAS:UniProtKB.::GO:0051256; P:spindle midzone assembly involved in mitosis; IMP:UniProtKB. | 101 | P10533 | 367 | RMIL_AVII1 Serine/threonine-protein kinase-tr... | 205 | 0.069 | 41.2 | 21 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 102 | P35761 | 856 | TTK_MOUSE Dual specificity protein kinase TTK... | 178 | 0.071 | 41.6 | 21 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 103 | Q8T2I8 | 1167 | SEPA_DICDI Serine/threonine-protein kinase se... | 185 | 0.071 | 41.6 | 24 | 42 | GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW. | 104 | P70032 | 598 | PLK1_XENLA Serine/threonine-protein kinase PL... | 155 | 0.074 | 41.6 | 24 | 46 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0000776; C:kinetochore; ISS:UniProtKB.::GO:0030496; C:midbody; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0051233; C:spindle midzone; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007092; P:activation of mitotic anaphase-promoting complex activity; ISS:UniProtKB.::GO:0051297; P:centrosome organization; ISS:UniProtKB.::GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.::GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.::GO:0007067; P:mitosis; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0001556; P:oocyte maturation; IDA:UniProtKB.::GO:0071168; P:protein localization to chromatin; ISS:UniProtKB. | 105 | Q9Z986 | 932 | PKND_CHLPN Serine/threonine-protein kinase pk... | 193 | 0.075 | 41.6 | 24 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 106 | P27966 | 450 | RMIL_AVEVR Serine/threonine-protein kinase-tr... | 171 | 0.075 | 41.2 | 20 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 107 | Q3U214 | 1321 | MAST3_MOUSE Microtubule-associated serine/thr... | 154 | 0.078 | 41.6 | 23 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 108 | Q7TXA9 | 1110 | PKNK_MYCBO Probable serine/threonine-protein ... | 187 | 0.081 | 41.6 | 21 | 45 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 109 | P47809 | 397 | MP2K4_MOUSE Dual specificity mitogen-activate... | 156 | 0.081 | 41.2 | 26 | 46 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0000165; P:MAPK cascade; IPI:MGI.::GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 110 | Q5R8Z4 | 681 | PAK6_PONAB Serine/threonine-protein kinase PA... | 186 | 0.082 | 41.6 | 25 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 111 | Q62673 | 603 | PLK1_RAT Serine/threonine-protein kinase PLK1... | 155 | 0.082 | 41.2 | 23 | 48 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0030496; C:midbody; ISS:UniProtKB.::GO:0051233; C:spindle midzone; IDA:RGD.::GO:0000922; C:spindle pole; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007092; P:activation of mitotic anaphase-promoting complex activity; ISS:UniProtKB.::GO:0051297; P:centrosome organization; ISS:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.::GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.::GO:0000236; P:mitotic prometaphase; IMP:RGD.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0040038; P:polar body extrusion after meiotic divisions; IMP:RGD.::GO:0071168; P:protein localization to chromatin; ISS:UniProtKB.::GO:0046677; P:response to antibiotic; IEP:RGD. | 112 | Q9NQU5 | 681 | PAK6_HUMAN Serine/threonine-protein kinase PA... | 186 | 0.084 | 41.2 | 25 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; TAS:UniProtKB. | 113 | P45985 | 399 | MP2K4_HUMAN Dual specificity mitogen-activate... | 156 | 0.085 | 41.2 | 26 | 46 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0007254; P:JNK cascade; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 114 | Q1DN93 | 969 | ATG1_COCIM Serine/threonine-protein kinase AT... | 181 | 0.085 | 41.6 | 23 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 115 | Q05397 | 1052 | FAK1_HUMAN Focal adhesion kinase 1 OS=Homo sa... | 171 | 0.088 | 41.6 | 23 | 46 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008432; F:JUN kinase binding; IDA:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; TAS:UniProtKB.::GO:0007411; P:axon guidance; TAS:UniProtKB.::GO:0048870; P:cell motility; TAS:UniProtKB.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0009790; P:embryo development; TAS:UniProtKB.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0030010; P:establishment of cell polarity; TAS:UniProtKB.::GO:0060396; P:growth hormone receptor signaling pathway; IDA:BHF-UCL.::GO:0003007; P:heart morphogenesis; TAS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; IMP:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0022408; P:negative regulation of cell-cell adhesion; IDA:BHF-UCL.::GO:0038007; P:netrin-activated signaling pathway; TAS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0001890; P:placenta development; TAS:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; TAS:UniProtKB.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:UniProtKB.::GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:UniProtKB.::GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0051493; P:regulation of cytoskeleton organization; TAS:UniProtKB.::GO:0010594; P:regulation of endothelial cell migration; TAS:UniProtKB.::GO:0051893; P:regulation of focal adhesion assembly; TAS:UniProtKB.::GO:0045667; P:regulation of osteoblast differentiation; IMP:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; TAS:UniProtKB.::GO:0007172; P:signal complex assembly; IEA:InterPro. | 116 | O35346 | 1055 | FAK1_RAT Focal adhesion kinase 1 OS=Rattus no... | 171 | 0.089 | 41.6 | 23 | 46 | GO:0016324; C:apical plasma membrane; IDA:RGD.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IDA:RGD.::GO:0014704; C:intercalated disc; IDA:RGD.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0016604; C:nuclear body; IDA:RGD.::GO:0005730; C:nucleolus; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0042383; C:sarcolemma; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005178; F:integrin binding; IPI:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030644; P:cellular chloride ion homeostasis; IMP:RGD.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0045444; P:fat cell differentiation; IEP:RGD.::GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.::GO:0007254; P:JNK cascade; IMP:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0030336; P:negative regulation of cell migration; IMP:RGD.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0045785; P:positive regulation of cell adhesion; IMP:RGD.::GO:0030307; P:positive regulation of cell growth; IMP:RGD.::GO:0060252; P:positive regulation of glial cell proliferation; IMP:RGD.::GO:0050766; P:positive regulation of phagocytosis; IMP:RGD.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.::GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; ISS:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.::GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.::GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.::GO:0050806; P:positive regulation of synaptic transmission; IMP:RGD.::GO:0045909; P:positive regulation of vasodilation; IMP:RGD.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0045667; P:regulation of osteoblast differentiation; ISS:UniProtKB.::GO:0046685; P:response to arsenic-containing substance; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0032355; P:response to estradiol stimulus; IEP:RGD.::GO:0009749; P:response to glucose stimulus; IEP:RGD.::GO:0009612; P:response to mechanical stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IEP:RGD.::GO:0007172; P:signal complex assembly; IEA:InterPro. | 117 | P53350 | 603 | PLK1_HUMAN Serine/threonine-protein kinase PL... | 155 | 0.089 | 41.2 | 23 | 48 | GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0000942; C:condensed nuclear chromosome outer kinetochore; IDA:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030496; C:midbody; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005876; C:spindle microtubule; IDA:BHF-UCL.::GO:0051233; C:spindle midzone; IDA:UniProtKB.::GO:0000922; C:spindle pole; IDA:BHF-UCL. | | | | | | | | | | GO:0010997; F:anaphase-promoting complex binding; IPI:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; IDA:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007092; P:activation of mitotic anaphase-promoting complex activity; IDA:UniProtKB.::GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0051297; P:centrosome organization; IMP:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; IDA:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:UniProtKB.::GO:0001578; P:microtubule bundle formation; IDA:UniProtKB.::GO:0007091; P:mitotic metaphase/anaphase transition; TAS:Reactome.::GO:0000236; P:mitotic prometaphase; TAS:Reactome.::GO:0000088; P:mitotic prophase; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity; IMP:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IMP:BHF-UCL.::GO:0031648; P:protein destabilization; IDA:UniProtKB.::GO:0071168; P:protein localization to chromatin; IDA:UniProtKB.::GO:0016567; P:protein ubiquitination; IDA:UniProtKB.::GO:0090007; P:regulation of mitotic anaphase; IMP:BHF-UCL.::GO:0043393; P:regulation of protein binding; IMP:BHF-UCL. | 118 | Q07192 | 446 | MP2K2_XENLA Dual specificity mitogen-activate... | 156 | 0.09 | 41.2 | 26 | 44 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 119 | P34152 | 1090 | FAK1_MOUSE Focal adhesion kinase 1 OS=Mus mus... | 171 | 0.093 | 41.2 | 23 | 46 | GO:0016324; C:apical plasma membrane; IDA:MGI.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:MGI.::GO:0021955; P:central nervous system neuron axonogenesis; IMP:MGI.::GO:0043542; P:endothelial cell migration; IMP:MGI.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0040023; P:establishment of nucleus localization; IDA:MGI.::GO:0030198; P:extracellular matrix organization; IMP:MGI.::GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.::GO:0000226; P:microtubule cytoskeleton organization; IDA:MGI.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0050771; P:negative regulation of axonogenesis; IMP:MGI.::GO:0046621; P:negative regulation of organ growth; IGI:MGI.::GO:0051964; P:negative regulation of synapse assembly; IMP:MGI.::GO:0001764; P:neuron migration; IDA:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.::GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; ISS:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.::GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0045667; P:regulation of osteoblast differentiation; ISS:UniProtKB.::GO:0007172; P:signal complex assembly; IEA:InterPro.::GO:0001570; P:vasculogenesis; IMP:MGI. | 120 | Q6P0Q8 | 1798 | MAST2_HUMAN Microtubule-associated serine/thr... | 154 | 0.095 | 41.6 | 25 | 47 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0019902; F:phosphatase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0045075; P:regulation of interleukin-12 biosynthetic process; ISS:UniProtKB.::GO:0048515; P:spermatid differentiation; ISS:UniProtKB. | 121 | D7UQM5 | 407 | AURK_ASTPE Aurora kinase OS=Asterina pectinif... | 100 | 0.097 | 40.8 | 34 | 46 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. |
