| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
301 | P04049 | 648 | RAF1_HUMAN RAF proto-oncogene serine/threonin... | 123 | 4.6 | 35.8 | 23 | 50 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005741; C:mitochondrial outer membrane; TAS:ProtInc.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:UniProtKB.::GO:0031333; P:negative regulation of protein complex assembly; IDA:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0045595; P:regulation of cell differentiation; TAS:UniProtKB.::GO:2000145; P:regulation of cell motility; TAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; TAS:UniProtKB.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 302 | P22517 | 447 | KCC2_YEAST Calcium/calmodulin-dependent prote... | 101 | 4.6 | 35.4 | 33 | 48 | GO:0005737; C:cytoplasm; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:SGD. | | | | | | | | | | GO:0007165; P:signal transduction; NAS:SGD. | 303 | Q1ZXR2 | 844 | Y7566_DICDI Probable serine/threonine-protein... | 194 | 4.6 | 35.8 | 21 | 44 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 304 | Q16W24 | 769 | PLK4_AEDAE Serine/threonine-protein kinase PL... | 205 | 4.7 | 35.8 | 24 | 39 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 305 | Q683C9 | 282 | AUR2_ARATH Serine/threonine-protein kinase Au... | 122 | 4.9 | 35 | 30 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035175; F:histone kinase activity (H3-S10 specific); IDA:TAIR. | | | | | | | | | | | 306 | Q5R4F3 | 898 | TAOK3_PONAB Serine/threonine-protein kinase T... | 187 | 5.1 | 35.8 | 24 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB. | 307 | O15021 | 2626 | MAST4_HUMAN Microtubule-associated serine/thr... | 154 | 5.1 | 35.8 | 24 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 308 | B4LDJ6 | 781 | PLK4_DROVI Serine/threonine-protein kinase PL... | 174 | 5.4 | 35.4 | 26 | 44 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 309 | P83102 | 828 | DYRK3_DROME Putative dual specificity tyrosin... | 146 | 5.4 | 35.4 | 25 | 40 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 310 | Q9H2K8 | 898 | TAOK3_HUMAN Serine/threonine-protein kinase T... | 188 | 5.5 | 35.4 | 24 | 40 | GO:0005739; C:mitochondrion; IDA:HPA.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.::GO:0004674; F:protein serine/threonine kinase activity; IDA:HGNC. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; IMP:UniProtKB.::GO:0000165; P:MAPK cascade; IMP:HGNC.::GO:0046329; P:negative regulation of JNK cascade; IDA:HGNC.::GO:0046330; P:positive regulation of JNK cascade; IMP:HGNC.::GO:0046777; P:protein autophosphorylation; IDA:HGNC. | 311 | Q9NZJ5 | 1116 | E2AK3_HUMAN Eukaryotic translation initiation... | 110 | 5.7 | 35.4 | 24 | 46 | GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IDA:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.::GO:0030282; P:bone mineralization; ISS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.::GO:0002063; P:chondrocyte development; ISS:UniProtKB.::GO:0031018; P:endocrine pancreas development; IMP:UniProtKB.::GO:0007029; P:endoplasmic reticulum organization; ISS:UniProtKB.::GO:0006983; P:ER overload response; IDA:UniProtKB.::GO:0030073; P:insulin secretion; ISS:UniProtKB.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.::GO:0032057; P:negative regulation of translational initiation in response to stress; TAS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0051260; P:protein homooligomerization; IMP:UniProtKB. | 312 | Q99N57 | 648 | RAF1_MOUSE RAF proto-oncogene serine/threonin... | 123 | 6 | 35.4 | 23 | 50 | GO:0005829; C:cytosol; TAS:MGI.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0031143; C:pseudopodium; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0017016; F:Ras GTPase binding; IPI:MGI. | | | | | | | | | | GO:0006915; P:apoptotic process; IMP:MGI.::GO:0007010; P:cytoskeleton organization; IMP:MGI.::GO:0048011; P:nerve growth factor receptor signaling pathway; IMP:MGI. | 313 | Q811L6 | 2618 | MAST4_MOUSE Microtubule-associated serine/thr... | 153 | 6.1 | 35.4 | 24 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 314 | Q9M077 | 294 | AUR1_ARATH Serine/threonine-protein kinase Au... | 105 | 6.1 | 34.7 | 30 | 44 | GO:0009504; C:cell plate; IDA:TAIR.::GO:0005874; C:microtubule; IDA:TAIR.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005730; C:nucleolus; IDA:TAIR.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035175; F:histone kinase activity (H3-S10 specific); IDA:TAIR. | | | | | | | | | | | 315 | Q6PHR2 | 472 | ULK3_HUMAN Serine/threonine-protein kinase UL... | 86 | 6.4 | 35 | 31 | 51 | GO:0000407; C:pre-autophagosomal structure; TAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006914; P:autophagy; TAS:UniProtKB.::GO:0090398; P:cellular senescence; TAS:UniProtKB.::GO:0045879; P:negative regulation of smoothened signaling pathway; IDA:UniProtKB.::GO:0045880; P:positive regulation of smoothened signaling pathway; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB. | 316 | B4J3F1 | 762 | PLK4_DROGR Serine/threonine-protein kinase PL... | 174 | 7.5 | 35 | 25 | 45 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 317 | Q9BQI3 | 630 | E2AK1_HUMAN Eukaryotic translation initiation... | 165 | 7.6 | 35 | 23 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IDA:UniProtKB.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB. | | | | | | | | | | GO:0046986; P:negative regulation of hemoglobin biosynthetic process; ISS:UniProtKB.::GO:0045993; P:negative regulation of translational initiation by iron; NAS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0009605; P:response to external stimulus; IEP:UniProtKB.::GO:0006950; P:response to stress; IEP:UniProtKB. | 318 | A2QIL5 | 1007 | ATG1_ASPNC Serine/threonine-protein kinase at... | 181 | 8.2 | 35 | 23 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 319 | B4KYX8 | 778 | PLK4_DROMO Serine/threonine-protein kinase PL... | 98 | 8.5 | 35 | 32 | 48 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 320 | Q9QY01 | 1037 | ULK2_MOUSE Serine/threonine-protein kinase UL... | 175 | 8.8 | 35 | 25 | 43 | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0034045; C:pre-autophagosomal structure membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0048675; P:axon extension; IMP:MGI.::GO:0048671; P:negative regulation of collateral sprouting; IMP:MGI.::GO:0010506; P:regulation of autophagy; IMP:UniProtKB.::GO:0042594; P:response to starvation; IDA:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 321 | P97756 | 505 | KKCC1_RAT Calcium/calmodulin-dependent protei... | 152 | 8.8 | 34.7 | 22 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:RGD. | | | | | | | | | | GO:0032147; P:activation of protein kinase activity; IDA:RGD. | 322 | Q8VDG6 | 1002 | M3KL4_MOUSE Mitogen-activated protein kinase ... | 148 | 9.2 | 34.7 | 24 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | |
