| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | A1IGU5 | 675 | ARH37_HUMAN Rho guanine nucleotide exchange f... | 175 | 0.00000001 | 62.8 | 25 | 44 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 2 | A1IGU3 | 676 | ARH37_RAT Rho guanine nucleotide exchange fac... | 175 | 0.00000004 | 60.8 | 26 | 43 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 3 | A1IGU4 | 676 | ARH37_MOUSE Rho guanine nucleotide exchange f... | 164 | 0.0000006 | 57 | 24 | 41 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 4 | Q9NHV9 | 793 | VAV_DROME Protein vav OS=Drosophila melanogas... | 193 | 0.00002 | 52.4 | 26 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IDA:FlyBase.::GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0007155; P:cell adhesion; IMP:FlyBase.::GO:0016477; P:cell migration; IMP:FlyBase.::GO:0007417; P:central nervous system development; IGI:FlyBase.::GO:0007391; P:dorsal closure; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007520; P:myoblast fusion; IMP:FlyBase.::GO:0007424; P:open tracheal system development; IMP:FlyBase.::GO:0072499; P:photoreceptor cell axon guidance; IMP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 5 | O15068 | 1137 | MCF2L_HUMAN Guanine nucleotide exchange facto... | 164 | 0.00007 | 50.4 | 24 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 6 | Q63406 | 1149 | MCF2L_RAT Guanine nucleotide exchange factor ... | 185 | 0.0001 | 49.7 | 24 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 7 | Q6TXD4 | 1580 | DNMBP_MOUSE Dynamin-binding protein OS=Mus mu... | 164 | 0.0001 | 49.7 | 21 | 41 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 8 | Q6XZF7 | 1577 | DNMBP_HUMAN Dynamin-binding protein OS=Homo s... | 182 | 0.0003 | 48.9 | 21 | 42 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 9 | Q15052 | 776 | ARHG6_HUMAN Rho guanine nucleotide exchange f... | 243 | 0.0003 | 48.5 | 23 | 41 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; NAS:UniProtKB.::GO:0034329; P:cell junction assembly; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0007254; P:JNK cascade; NAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 10 | Q5XXR3 | 772 | ARHG6_RAT Rho guanine nucleotide exchange fac... | 217 | 0.0003 | 48.5 | 24 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 11 | Q8K4I3 | 771 | ARHG6_MOUSE Rho guanine nucleotide exchange f... | 217 | 0.0005 | 47.8 | 24 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 12 | P91620 | 2061 | SIF2_DROME Protein still life, isoforms C/SIF... | 228 | 0.0007 | 47.4 | 22 | 38 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0050770; P:regulation of axonogenesis; IGI:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0050803; P:regulation of synapse structure and activity; TAS:FlyBase. | 13 | Q9NR80 | 690 | ARHG4_HUMAN Rho guanine nucleotide exchange f... | 225 | 0.001 | 46.6 | 23 | 40 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IMP:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 14 | Q86VW2 | 580 | ARHGP_HUMAN Rho guanine nucleotide exchange f... | 201 | 0.001 | 46.6 | 23 | 40 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 15 | Q45FX5 | 1007 | VAV_CAEEL Protein vav-1 OS=Caenorhabditis ele... | 215 | 0.001 | 46.6 | 24 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:WormBase.::GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 16 | P27870 | 845 | VAV_MOUSE Proto-oncogene vav OS=Mus musculus ... | 196 | 0.001 | 46.2 | 24 | 45 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IGI:MGI. | | | | | | | | | | GO:0006955; P:immune response; IMP:MGI.::GO:0007229; P:integrin-mediated signaling pathway; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0006909; P:phagocytosis; IGI:MGI.::GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.::GO:0043087; P:regulation of GTPase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0030217; P:T cell differentiation; TAS:MGI. | 17 | P91621 | 2072 | SIF1_DROME Protein still life, isoform SIF ty... | 220 | 0.001 | 46.2 | 22 | 38 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0050770; P:regulation of axonogenesis; IGI:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0050803; P:regulation of synapse structure and activity; TAS:FlyBase. | 18 | Q6P720 | 579 | ARHGP_RAT Rho guanine nucleotide exchange fac... | 201 | 0.002 | 45.4 | 23 | 39 | GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 19 | P54100 | 843 | VAV_RAT Proto-oncogene vav OS=Rattus norvegic... | 196 | 0.003 | 45.1 | 24 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0048468; P:cell development; TAS:RGD.::GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IEP:RGD.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 20 | Q5ZLR6 | 764 | ARHG6_CHICK Rho guanine nucleotide exchange f... | 218 | 0.003 | 45.1 | 21 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 21 | Q9NXL2 | 219 | ARH38_HUMAN Rho guanine nucleotide exchange f... | 95 | 0.004 | 43.5 | 26 | 54 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 22 | Q91VS8 | 1065 | FARP2_MOUSE FERM, RhoGEF and pleckstrin domai... | 204 | 0.004 | 44.7 | 23 | 42 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0019898; C:extrinsic to membrane; IEA:InterPro. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 23 | Q64096 | 1149 | MCF2L_MOUSE Guanine nucleotide exchange facto... | 186 | 0.005 | 44.7 | 25 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005545; F:1-phosphatidylinositol binding; IDA:MGI.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:MGI. | | | | | | | | | | GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; IDA:MGI. | 24 | Q08DN7 | 844 | VAV_BOVIN Proto-oncogene vav OS=Bos taurus (B... | 196 | 0.006 | 44.3 | 24 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 25 | Q80VK6 | 219 | ARH38_MOUSE Rho guanine nucleotide exchange f... | 133 | 0.006 | 43.1 | 22 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 26 | Q9H7P9 | 1386 | PKHG2_HUMAN Pleckstrin homology domain-contai... | 156 | 0.009 | 43.9 | 23 | 38 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 27 | Q54B37 | 1155 | GXCJ_DICDI RhoGEF domain-containing protein g... | 187 | 0.009 | 43.9 | 23 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 28 | Q12802 | 2813 | AKP13_HUMAN A-kinase anchor protein 13 OS=Hom... | 121 | 0.041 | 41.6 | 23 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004691; F:cAMP-dependent protein kinase activity; NAS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0004871; F:signal transducer activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 29 | Q80U35 | 2057 | ARHGH_MOUSE Rho guanine nucleotide exchange f... | 213 | 0.044 | 41.6 | 23 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 30 | P15498 | 845 | VAV_HUMAN Proto-oncogene vav OS=Homo sapiens ... | 193 | 0.045 | 41.2 | 23 | 44 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome. | 31 | P97433 | 1693 | RGNEF_MOUSE Rho-guanine nucleotide exchange f... | 201 | 0.049 | 41.2 | 19 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0021955; P:central nervous system neuron axonogenesis; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0060052; P:neurofilament cytoskeleton organization; IMP:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |
