ID 5H1A_HUMAN STANDARD; PRT; 422 AA. AC P08908; DT 01-NOV-1988 (Rel. 09, Created) DT 01-APR-1993 (Rel. 25, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 1A receptor (5-HT-1A) (Serotonin receptor 1A) (5- DE HT1A) (G-21). GN HTR1A. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=87315369; PubMed=3041227; RA Kobilka B.K., Frielle T., Collins S., Yang-Feng T.L., Kobilka T.S., RA Francke U., Lefkowitz R.J., Caron M.G.; RT "An intronless gene encoding a potential member of the family of RT receptors coupled to guanine nucleotide regulatory proteins."; RL Nature 329:75-79(1987). RN [2] RP SEQUENCE FROM N.A. RA Saltzman A.G., Morse B., Felder S.; RL Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RA Kitano T., Kobayakawa H., Saitou N.; RT "Silver project."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP FUNCTION. RX MEDLINE=88334700; PubMed=3138543; RA Fargin A., Raymond J.R., Lohse M.L., Kobilka B.K., Caron M.G., RA Lefkowitz R.J.; RT "The genomic clone G-21 which resembles a beta-adrenergic receptor RT sequence encodes the 5-HT1A receptor."; RL Nature 335:358-360(1988). RN [6] RP VARIANTS SER-22 AND VAL-28. RX MEDLINE=95275307; PubMed=7755630; RA Nakhai B., Nielsen D.A., Linnoila M., Goldman D.; RT "Two naturally occurring amino acid substitutions in the human 5-HT1A RT receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28."; RL Biochem. Biophys. Res. Commun. 210:530-536(1995). RN [7] RP VARIANTS LEU-16 AND ASP-273. RX MEDLINE=98425601; PubMed=9754630; RA Kawanishi Y., Harada S., Tachikawa H., Okubo T., Shiraishi H.; RT "Novel mutations in the promoter and coding region of the human 5-HT1A RT receptor gene and association analysis in schizophrenia."; RL Am. J. Med. Genet. 81:434-439(1998). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Strongest to the other 5HT-1 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M28269; AAA36440.1; -. DR EMBL; X13556; CAA31908.1; -. DR EMBL; X57829; CAA40962.1; -. DR EMBL; M83181; AAA66493.1; -. DR EMBL; AB041403; BAA94488.1; -. DR EMBL; AF498978; AAM21125.1; -. DR PIR; I38209; I38209. DR HSSP; P08913; 1HLL. DR Genew; HGNC:5286; HTR1A. DR MIM; 109760; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007610; P:behavior; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00512; 5HT1ARECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Polymorphism. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 62 1 (Potential). FT DOMAIN 63 73 Cytoplasmic (Potential). FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 109 Extracellular (Potential). FT TRANSMEM 110 132 3 (Potential). FT DOMAIN 133 152 Cytoplasmic (Potential). FT TRANSMEM 153 178 4 (Potential). FT DOMAIN 179 191 Extracellular (Potential). FT TRANSMEM 192 217 5 (Potential). FT DOMAIN 218 345 Cytoplasmic (Potential). FT TRANSMEM 346 367 6 (Potential). FT DOMAIN 368 378 Extracellular (Potential). FT TRANSMEM 379 403 7 (Potential). FT DOMAIN 404 422 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT DISULFID 109 187 By similarity. FT VARIANT 16 16 P -> L (in dbSNP:1800041). FT /FTId=VAR_003446. FT VARIANT 22 22 G -> S (in dbSNP:1799920). FT /FTId=VAR_011826. FT VARIANT 28 28 I -> V (in dbSNP:1799921). FT /FTId=VAR_011827. FT VARIANT 184 184 P -> L (in dbSNP:1800043). FT /FTId=VAR_011828. FT VARIANT 220 220 R -> L (in dbSNP:1800044). FT /FTId=VAR_011829. FT VARIANT 273 273 G -> D (in dbSNP:1800042). FT /FTId=VAR_011830. FT CONFLICT 152 154 RAA -> PR (in Ref. 1). FT CONFLICT 172 172 M -> I (in Ref. 1). FT CONFLICT 418 418 K -> N (in Ref. 1). SQ SEQUENCE 422 AA; 46106 MW; 762664FCF62CFD8F CRC64; MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC RQ // ID A2AA_HUMAN STANDARD; PRT; 450 AA. AC P08913; Q9BZK1; DT 01-NOV-1988 (Rel. 09, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A DE adrenoreceptor) (Alpha-2AAR subtype C10). GN ADRA2A OR ADRA2R OR ADRAR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=89308571; PubMed=2568356; RA Fraser C.M., Arakawa S., McCombie W.R., Venter J.C.; RT "Cloning, sequence analysis, and permanent expression of a human RT alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence RT for independent pathways of receptor coupling to adenylate cyclase RT attenuation and activation."; RL J. Biol. Chem. 264:11754-11761(1989). RN [2] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC TISSUE=Platelet; RX MEDLINE=88042789; PubMed=2823383; RA Kobilka B.K., Matsui H., Kobilka T.S., Yang-Feng T.L., Francke U., RA Caron M.G., Lefkowitz R.J., Regan J.W.; RT "Cloning, sequencing, and expression of the gene coding for the human RT platelet alpha 2-adrenergic receptor."; RL Science 238:650-656(1987). RN [3] RP REVISIONS TO 333-365. RX MEDLINE=91009167; PubMed=2170371; RA Guyer C.A., Horstman D.A., Wilson A.L., Clark J.D., Kragoe E.J. Jr., RA Limbird L.E.; RT "Cloning, sequencing, and expression of the gene encoding the porcine RT alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and RT amiloride analogs."; RL J. Biol. Chem. 265:17307-17317(1990). RN [4] RP SEQUENCE FROM N.A. RA Castellano M., Giacche' M., Rossi F., Rivadossi F., Perani C., RA Beschi M., Agabiti Rosei E.; RT "A search for genetic variability in the human alpha-2 adrenergic RT receptor on chromosome 10."; RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE FROM N.A., AND VARIANT LYS-251. RX MEDLINE=20556293; PubMed=10948191; RA Small K.M., Forbes S.L., Brown K.M., Liggett S.B.; RT "An Asn to Lys polymorphism in the third intracellular loop of the RT human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted RT Gi coupling."; RL J. Biol. Chem. 275:38518-38523(2000). RN [6] RP SEQUENCE FROM N.A. RA Mao Z.-M., Tang K., Li B.-M., Jing N.-H.; RT "Cloning and expression of human alpha-2A adrenergic receptor in SY5Y RT cells."; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [7] RP SEQUENCE FROM N.A. RA Liu L., Yuan L.; RT "Human alpha-2A adrenergic receptor gene and the genotype of -1296 RT nucleotide and motionsickness."; RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. RN [8] RP SEQUENCE FROM N.A. RC TISSUE=PNS; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [9] RP MUTAGENESIS OF PHE-412. RX MEDLINE=91332079; PubMed=1678390; RA Suryanarayana S., Daunt D.A., von Zastrow M., Kobilka B.K.; RT "A point mutation in the seventh hydrophobic domain of the alpha 2 RT adrenergic receptor increases its affinity for a family of beta RT receptor antagonists."; RL J. Biol. Chem. 266:15488-15492(1991). RN [10] RP MUTAGENESIS OF ASPARTIC ACID AND SERINE RESIDUES. RX MEDLINE=91342598; PubMed=1678850; RA Wang C.-D., Buck M.A., Fraser C.M.; RT "Site-directed mutagenesis of alpha 2a-adrenergic receptors: RT Identification of amino acids involved in ligand binding and receptor RT activation by agonists."; RL Mol. Pharmacol. 40:168-179(1991). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. The rank order of potency for agonists of this receptor CC is oxymetazoline > clonidine > epinephrine > norepinephrine > CC phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = CC p-octopamine. For antagonists, the rank order is yohimbine > CC phentolamine = mianserine > chlorpromazine = spiperone = prazosin CC > propanolol > alprenolol = pindolol. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M23533; AAA51665.1; -. DR EMBL; M18415; AAA51664.1; -. DR EMBL; AF262016; AAG00447.2; -. DR EMBL; AF281308; AAF91441.1; -. DR EMBL; AF316894; AAK01634.1; -. DR EMBL; AF284095; AAK26743.1; -. DR EMBL; AY032736; AAK51162.1; -. DR EMBL; BC050414; AAH50414.2; -. DR PIR; A34169; A34169. DR PDB; 1HLL; 10-APR-02. DR PDB; 1HO9; 24-JUL-02. DR PDB; 1HOD; 24-JUL-02. DR PDB; 1HOF; 24-JUL-02. DR Genew; HGNC:281; ADRA2A. DR MIM; 104210; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004938; F:alpha2-adrenergic receptor activity; TAS. DR GO; GO:0015459; F:potassium channel regulator activity; TAS. DR GO; GO:0030036; P:actin cytoskeleton organization and biogenesis; TAS. DR GO; GO:0000187; P:activation of MAPK; TAS. DR GO; GO:0006928; P:cell motility; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0007194; P:negative regulation of adenylate cyclase ac...; TAS. DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS. DR GO; GO:0007265; P:RAS protein signal transduction; TAS. DR GO; GO:0007266; P:Rho protein signal transduction; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00558; ADRENRGCA2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate; KW Polymorphism; 3D-structure. FT DOMAIN 1 33 Extracellular (Potential). FT TRANSMEM 34 59 1 (Potential). FT DOMAIN 60 70 Cytoplasmic (Potential). FT TRANSMEM 71 96 2 (Potential). FT DOMAIN 97 106 Extracellular (Potential). FT TRANSMEM 107 129 3 (Potential). FT DOMAIN 130 149 Cytoplasmic (Potential). FT TRANSMEM 150 173 4 (Potential). FT DOMAIN 174 192 Extracellular (Potential). FT TRANSMEM 193 217 5 (Potential). FT DOMAIN 218 374 Cytoplasmic (Potential). FT TRANSMEM 375 399 6 (Potential). FT DOMAIN 400 406 Extracellular (Potential). FT TRANSMEM 407 430 7 (Potential). FT DOMAIN 431 450 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT DISULFID 106 188 By similarity. FT LIPID 442 442 S-palmitoyl cysteine (By similarity). FT SITE 113 113 IMPLICATED IN LIGAND BINDING. FT SITE 200 200 IMPLICATED IN CATECHOL AGONIST BINDING FT AND RECEPTOR ACTIVATION. FT SITE 204 204 IMPLICATED IN CATECHOL AGONIST BINDING FT AND RECEPTOR ACTIVATION. FT VARIANT 251 251 N -> K (rare polymorphism; frequency FT in Caucasians 0.004 and in African- FT Americans 0.05; 40% increase in agonist- FT promoted Gi coupling; dbSNP:1800035). FT /FTId=VAR_014957. FT MUTAGEN 79 79 D->N: No change in binding affinity. FT eliminates guanine nucleotide-sensitive FT agonist binding. FT MUTAGEN 113 113 D->N: No binding to yohimbine. Increase FT in adenylate cyclase activity. FT MUTAGEN 130 130 D->N: Lower affinity for agonists. FT Eliminates guanine nucleotide-sensitive FT agonist binding. FT MUTAGEN 200 200 S->A: Lower affinity for agonists. No FT change in guanine nucleotide-sensitive FT agonist binding. FT MUTAGEN 204 204 S->A: Lower affinity for agonists. FT Reduced guanine nucleotide-sensitive FT agonist binding. FT MUTAGEN 412 412 F->N: 350-fold reduced affinity for FT alpha-2 antagonist yohimbine, 3000-fold FT increase for beta-antagonist alprenolol. FT CONFLICT 104 104 A -> T (in Ref. 2). FT CONFLICT 157 157 V -> C (in Ref. 2). FT CONFLICT 333 365 PRRGPGATGIGTPAAGPGEERVGAAKASRWRGR -> RGAG FT RGRRGSGRRLQGRGRSASGLPRRRAGAGG (in Ref. 1 FT and 2). FT CONFLICT 368 368 R -> L (in Ref. 2). FT HELIX 119 128 FT TURN 129 129 FT HELIX 130 139 FT HELIX 140 142 SQ SEQUENCE 450 AA; 48956 MW; A703CF262F04E8AC CRC64; MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLLTVFG NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI KAIIITVWVI SAVISFPPLI SIEKKGGGGG PQPAEPRCEI NDQKWYVISS CIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDAVA APPGGTERRP NGLGPERSAG PGGAEAEPLP TQLNGAPGEP APAGPRDTDA LDLEESSSSD HAERPPGPRR PERGPRGKGK ARASQVKPGD SLPRRGPGAT GIGTPAAGPG EERVGAAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLTAVG CSVPRTLFKF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV // ID B1AR_MACMU STANDARD; PRT; 480 AA. AC P47899; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1 DE adrenoreceptor). GN ADRB1. OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95078456; PubMed=7987008; RA Searles R.P., Nipper V.J., Machida C.A.; RT "The rhesus macaque beta 1-adrenergic receptor gene: structure of the RT gene and comparison of the flanking sequences with the rat beta 1- RT adrenergic receptor gene."; RL DNA Seq. 4:231-241(1994). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. This receptor binds epinephrine and norepinephrine with CC approximatively equal affinity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Homologous desensitization of the receptor is mediated by its CC phosphorylation by beta-adrenergic receptor kinase. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X75540; CAA53228.1; -. DR PIR; I53053; I53053. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00561; ADRENRGCB1AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR TIGRFAMs; TIGR01732; tiny_TM_bacill; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 59 Extracellular (Potential). FT TRANSMEM 60 83 1 (Potential). FT DOMAIN 84 96 Cytoplasmic (Potential). FT TRANSMEM 97 120 2 (Potential). FT DOMAIN 121 131 Extracellular (Potential). FT TRANSMEM 132 155 3 (Potential). FT DOMAIN 156 175 Cytoplasmic (Potential). FT TRANSMEM 176 199 4 (Potential). FT DOMAIN 200 221 Extracellular (Potential). FT TRANSMEM 222 245 5 (Potential). FT DOMAIN 246 328 Cytoplasmic (Potential). FT TRANSMEM 329 352 6 (Potential). FT DOMAIN 353 359 Extracellular (Potential). FT TRANSMEM 360 383 7 (Potential). FT DOMAIN 384 480 Cytoplasmic (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Probable). FT DISULFID 131 209 By similarity. FT MOD_RES 315 315 Phosphoserine (by PKA) (Potential). FT MOD_RES 415 415 Phosphoserine (by PKA) (Potential). FT LIPID 395 395 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 480 AA; 51608 MW; 25CB18FA03128084 CRC64; MGAGALVLGA SEPGNLSSAA PLPDGVATAA RLLVPASPPA SLLPPASEGP EPLSQQWTAG MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPS PSPVPAPPPG PPRPAAAAAT TAPLVNGRAG KRRPSRLVAL REQKALKTLG IIMGVFTLCW LPFFLANVVK AFHRELVPDR LFVFFNWLGY ANSAFNPIIY CRSPDFRNAF QRLLCCARRA ARRRHAAHGD RPRASGCLAR PGPPPSPGAA SDDDDDDVVG ATQPARLLEP WAGCNGGAAA DSDSSLDEPC RPGFASESKV // ID B1AR_HUMAN STANDARD; PRT; 477 AA. AC P08588; Q9UKG7; Q9UKG8; DT 01-AUG-1988 (Rel. 08, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1 DE adrenoreceptor). GN ADRB1 OR ADRB1R OR B1AR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RX MEDLINE=88068509; PubMed=2825170; RA Frielle T., Collins S., Daniel K.W., Caron M.G., Lefkowitz R.J., RA Kobilka B.K.; RT "Cloning of the cDNA for the human beta 1-adrenergic receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 84:7920-7924(1987). RN [2] RP SEQUENCE FROM N.A., AND VARIANTS GLY-49 AND GLY-389. RX MEDLINE=99407229; PubMed=10477438; RA Moore J.D., Mason D.A., Green S.A., Hsu J., Liggett S.B.; RT "Racial differences in the frequencies of cardiac beta(1)-adrenergic RT receptor polymorphisms: analysis of c145A>G and c1165G>C."; RL Hum. Mutat. 14:271-271(1999). RN [3] RP SEQUENCE FROM N.A., AND VARIANTS GLY-49; GLY-389 AND LEU-389. RA Rieder M.J., Daniels R.L., da Ponte S.H., Hastings N.C., Ahearn M.O., RA Rajkumar N., Yi Q., Nickerson D.A.; RT "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW- RT FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP VARIANT GLY-389. RX MEDLINE=99230291; PubMed=10212248; RA Mason D.A., Moore J.D., Green S.A., Liggett S.B.; RT "A gain-of-function polymorphism in a G-protein coupling domain of the RT human beta1-adrenergic receptor."; RL J. Biol. Chem. 274:12670-12674(1999). RN [5] RP VARIANT GLY-49. RX MEDLINE=20507547; PubMed=11052857; RA Borjesson M., Magnusson Y., Hjalmarson A., Andersson B.; RT "A novel polymorphism in the gene coding for the beta(1)-adrenergic RT receptor associated with survival in patients with heart failure."; RL Eur. Heart J. 21:1853-1858(2000). RN [6] RP VARIANT GLY-49. RX MEDLINE=21881226; PubMed=11854867; RA Ranade K., Jorgenson E., Sheu W.H.-H., Pei D., Hsiung C.A., RA Chiang F.-T., Chen Y.-D.I., Pratt R., Olshen R.A., Curb D., Cox D.R., RA Botstein D., Risch N.; RT "A polymorphism in the beta1 adrenergic receptor is associated with RT resting heart rate."; RL Am. J. Hum. Genet. 70:935-942(2002). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. This receptor binds epinephrine and norepinephrine with CC approximatively equal affinity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Homologous desensitization of the receptor is mediated by its CC phosphorylation by beta-adrenergic receptor kinase. CC -!- POLYMORPHISM: The variant Ser-49 is associated with high mean CC resting heart rate. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; J03019; AAA51667.1; -. DR EMBL; AF169006; AAD53696.1; -. DR EMBL; AF169007; AAD53697.1; -. DR EMBL; AY567837; AAS66983.1; -. DR PIR; A39911; QRHUB1. DR Genew; HGNC:285; ADRB1. DR MIM; 109630; -. DR MIM; 607276; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004940; F:beta1-adrenergic receptor activity; TAS. DR GO; GO:0007190; P:adenylate cyclase activation; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00561; ADRENRGCB1AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR TIGRFAMs; TIGR01732; tiny_TM_bacill; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate; KW Polymorphism. FT DOMAIN 1 59 Extracellular (Potential). FT TRANSMEM 60 83 1 (Potential). FT DOMAIN 84 96 Cytoplasmic (Potential). FT TRANSMEM 97 120 2 (Potential). FT DOMAIN 121 131 Extracellular (Potential). FT TRANSMEM 132 155 3 (Potential). FT DOMAIN 156 175 Cytoplasmic (Potential). FT TRANSMEM 176 199 4 (Potential). FT DOMAIN 200 221 Extracellular (Potential). FT TRANSMEM 222 245 5 (Potential). FT DOMAIN 246 325 Cytoplasmic (Potential). FT TRANSMEM 326 349 6 (Potential). FT DOMAIN 350 356 Extracellular (Potential). FT TRANSMEM 357 380 7 (Potential). FT DOMAIN 381 477 Cytoplasmic (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Probable). FT DISULFID 131 209 By similarity. FT MOD_RES 312 312 Phosphoserine (by PKA) (Potential). FT MOD_RES 412 412 Phosphoserine (by PKA) (Potential). FT LIPID 392 392 S-palmitoyl cysteine (By similarity). FT VARIANT 49 49 S -> G (in dbSNP:1801252). FT /FTId=VAR_009879. FT VARIANT 389 389 R -> G (reduced binding to G proteins; FT dbSNP:1801253). FT /FTId=VAR_009880. FT VARIANT 389 389 R -> L. FT /FTId=VAR_018742. SQ SEQUENCE 477 AA; 51322 MW; 0950F2684E4721B8 CRC64; MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP EPLSQQWTAG MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RELVPDRLFV FFNWLGYANS AFNPIIYCRS PDFRKAFQRL LCCARRAARR RHATHGDRPR ASGCLARPGP PPSPGAASDD DDDDVVGATP PARLLEPWAG CNGGAAADSD SSLDEPCRPG FASESKV // ID B1AR_CANFA STANDARD; PRT; 473 AA. AC P79148; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1 DE adrenoreceptor). GN ADRB1. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97364078; PubMed=9220370; RA Huang R.-R.C., Rapoport D., Schaeffer M.-T., Cascieri M.A., RA Fong T.M.; RT "Molecular cloning of the dog beta 1 and beta 2 adrenergic RT receptors."; RL J. Recept. Signal Transduct. Res. 17:599-607(1997). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. This receptor binds epinephrine and norepinephrine with CC approximatively equal affinity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Homologous desensitization of the receptor is mediated by its CC phosphorylation by beta-adrenergic receptor kinase (By CC similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U73207; AAB93648.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00561; ADRENRGCB1AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 59 Extracellular (Potential). FT TRANSMEM 60 83 1 (Potential). FT DOMAIN 84 96 Cytoplasmic (Potential). FT TRANSMEM 97 120 2 (Potential). FT DOMAIN 121 131 Extracellular (Potential). FT TRANSMEM 132 155 3 (Potential). FT DOMAIN 156 175 Cytoplasmic (Potential). FT TRANSMEM 176 199 4 (Potential). FT DOMAIN 200 221 Extracellular (Potential). FT TRANSMEM 222 245 5 (Potential). FT DOMAIN 246 322 Cytoplasmic (Potential). FT TRANSMEM 323 346 6 (Potential). FT DOMAIN 347 353 Extracellular (Potential). FT TRANSMEM 354 377 7 (Potential). FT DOMAIN 378 473 Cytoplasmic (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Probable). FT DISULFID 131 209 By similarity. FT MOD_RES 309 309 Phosphoserine (by PKA) (Potential). FT LIPID 389 389 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 473 AA; 50060 MW; 361357F7DF9DBD7E CRC64; MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVPASPSA SPLAPTSEGP APLSQQWTAG IGLLMALIVL LIVAGNVLVI AAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVM RGRWEYGSFL CELWTSVDVL CVTASIETLC VIALDRYLAI TAPFRYQSLL TRARARALVC TVWAISALVS FLPILMHWWR AGGDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPAPPPAPA PAPPPAPGSP RPAAAAPLAN GRVGRRRPSR LVALREQKAL KTLGIIMGVF TLCWLPFFLA NVVKAFHRDL VPDRLFVFFN WLGYANSAFN PIIYCRSPDF RRAFQRLLCC ARRAARGSHG AAGDPPRARP PPSPGAASDD DDDDEDDAGA GAGAAPPARL LEPWAGCNGG AAADSDSSLD GAGSPAGASE SRV // ID D2DR_MOUSE STANDARD; PRT; 444 AA. AC P61168; P13953; DT 01-JAN-1990 (Rel. 13, Created) DT 01-JAN-1990 (Rel. 13, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE D(2) dopamine receptor. GN DRD2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. (ISOFORMS LONG AND SHORT). RX MEDLINE=91122293; PubMed=1991517; RA Montmayeur J.P., Bausero P., Amlaiky N., Maroteaux L., Hen R., RA Borrelli E.; RT "Differential expression of the mouse D2 dopamine receptor isoforms."; RL FEBS Lett. 278:239-243(1991). CC -!- FUNCTION: This is one of the five types (D1 to D5) of receptors CC for dopamine. The activity of this receptor is mediated by G CC proteins which inhibit adenylyl cyclase. CC -!- SUBUNIT: Interacts with neurabin II (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Long; CC IsoId=P61168-1, P13953-1; Sequence=Displayed; CC Name=Short; CC IsoId=P61168-2, P13953-2; Sequence=VSP_010241; CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X55674; CAA39209.1; -. DR PIR; S13921; DYMSD2. DR MGD; MGI:94924; Drd2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PRINTS; PR00567; DOPAMINED2R. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Alternative splicing. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 60 1 (Potential). FT DOMAIN 61 71 Cytoplasmic (Potential). FT TRANSMEM 72 97 2 (Potential). FT DOMAIN 98 108 Extracellular (Potential). FT TRANSMEM 109 130 3 (Potential). FT DOMAIN 131 151 Cytoplasmic (Potential). FT TRANSMEM 152 174 4 (Potential). FT DOMAIN 175 186 Extracellular (Potential). FT TRANSMEM 187 210 5 (Potential). FT DOMAIN 211 374 Cytoplasmic (Potential). FT TRANSMEM 375 398 6 (Potential). FT DOMAIN 399 406 Extracellular (Potential). FT TRANSMEM 407 430 7 (Potential). FT DOMAIN 431 444 Cytoplasmic (Potential). FT DOMAIN 211 374 Interaction with neurabin II (By FT similarity). FT SITE 193 193 Implicated in catechol agonist binding. FT SITE 194 194 Implicated in receptor activation. FT SITE 197 197 Implicated in receptor activation. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT DISULFID 107 182 By similarity. FT VARSPLIC 242 270 Missing (in isoform Short). FT /FTId=VSP_010241. SQ SEQUENCE 444 AA; 50903 MW; 216E56CEE5CA32FB CRC64; MDPLNLSWYD DDLERQNWSR PFNGSEGKAD RPHYNYYAML LTLLIFIIVF GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFMK ILHC // ID D2DR_RAT STANDARD; PRT; 444 AA. AC P61169; P13953; DT 01-JAN-1990 (Rel. 13, Created) DT 01-JAN-1990 (Rel. 13, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE D(2) dopamine receptor. GN DRD2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. (ISOFORM SHORT). RC TISSUE=Brain; RX MEDLINE=89082643; PubMed=2974511; RA Bunzow J.R., van Tol H.H.M., Grandy D.K., Albert P., Salon J., RA Christie M., Machida C.A., Neve K.A., Civelli O.; RT "Cloning and expression of a rat D2 dopamine receptor cDNA."; RL Nature 336:783-787(1988). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=90081866; PubMed=2531846; RA Eidne K.A., Taylor P.L., Zabavnik J., Saunders P.T.K., Inglis J.D.; RT "D2 receptor, a missing exon."; RL Nature 342:865-865(1989). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=90081872; PubMed=2531847; RA Giros B., Sokoloff P., Martres M.-P., Riou J.-F., Emorine L.J., RA Schwartz J.-C.; RT "Alternative splicing directs the expression of two D2 dopamine RT receptor isoforms."; RL Nature 342:923-926(1989). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=90081873; PubMed=2480527; RA Monsma F.J. Jr., McVittie L.D., Gerfen C.R., Mahan L.C., Sibley D.R.; RT "Multiple D2 dopamine receptors produced by alternative RNA RT splicing."; RL Nature 342:926-929(1989). RN [5] RP SEQUENCE FROM N.A. RX MEDLINE=90235966; PubMed=2139615; RA Rao D.D., McKelvy J., Kebabian J., MacKenzie R.G.; RT "Two forms of the rat D2 dopamine receptor as revealed by the RT polymerase chain reaction."; RL FEBS Lett. 263:18-22(1990). RN [6] RP SEQUENCE FROM N.A. (ISOFORM LONG). RC STRAIN=Sprague-Dawley; RA Taylor P.L., Inglis J.D., Eidne K.A.; RT "5'untranslated region of rat pituitary dopamine D2(B) receptor RT contains a putative CpG island."; RL Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases. RN [7] RP SEQUENCE OF 242-270 FROM N.A. RX MEDLINE=90147685; PubMed=2137336; RA Miller J.C., Wang Y., Filer D.; RT "Identification by sequence analysis of a second rat brain cDNA RT encoding the dopamine (D2) receptor."; RL Biochem. Biophys. Res. Commun. 166:109-112(1990). RN [8] RP SEQUENCE OF 242-270 FROM N.A. RX MEDLINE=90201380; PubMed=2138567; RA O'Dowd B.F., Nguyen T., Tirpak A., Jarvie K.R., Israel Y., Seeman P., RA Niznik H.B.; RT "Cloning of two additional catecholamine receptors from rat brain."; RL FEBS Lett. 262:8-12(1990). RN [9] RP MUTAGENESIS OF SER-193; SER-194; SER-197 AND SER-420. RX MEDLINE=92333328; PubMed=1321233; RA Cox B.A., Henningsen R.A., Spanoyannis A., Neve R.L., Neve K.A.; RT "Contributions of conserved serine residues to the interactions of RT ligands with dopamine D2 receptors."; RL J. Neurochem. 59:627-635(1992). RN [10] RP INTERACTION WITH NEURABIN II. RX MEDLINE=99321921; PubMed=10391935; RA Smith F.D., Oxford G.S., Milgram S.L.; RT "Association of the D2 dopamine receptor third cytoplasmic loop with RT spinophilin, a protein phosphatase-1-interacting protein."; RL J. Biol. Chem. 274:19894-19900(1999). RN [11] RP 3D-STRUCTURE MODELING. RX MEDLINE=93038566; PubMed=1358063; RA Livingstone C.D., Strange P.G., Naylor L.H.; RT "Molecular modelling of D2-like dopamine receptors."; RL Biochem. J. 287:277-282(1992). CC -!- FUNCTION: This is one of the five types (D1 to D5) of receptors CC for dopamine. The activity of this receptor is mediated by G CC proteins which inhibit adenylyl cyclase. CC -!- SUBUNIT: Interacts with neurabin II. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Long; CC IsoId=P61169-1, P13953-1; Sequence=Displayed; CC Name=Short; CC IsoId=P61169-2, P13953-2; Sequence=VSP_001871; CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M36831; AAA41075.1; -. DR EMBL; X53278; CAA37373.1; -. DR EMBL; X56065; CAA39543.1; -. DR EMBL; M32241; AAA41074.1; -. DR PIR; S08146; S08146. DR RGD; 2520; Drd2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PRINTS; PR00567; DOPAMINED2R. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Alternative splicing. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 60 1 (Potential). FT DOMAIN 61 71 Cytoplasmic (Potential). FT TRANSMEM 72 97 2 (Potential). FT DOMAIN 98 108 Extracellular (Potential). FT TRANSMEM 109 130 3 (Potential). FT DOMAIN 131 151 Cytoplasmic (Potential). FT TRANSMEM 152 174 4 (Potential). FT DOMAIN 175 186 Extracellular (Potential). FT TRANSMEM 187 210 5 (Potential). FT DOMAIN 211 374 Cytoplasmic (Potential). FT TRANSMEM 375 398 6 (Potential). FT DOMAIN 399 406 Extracellular (Potential). FT TRANSMEM 407 430 7 (Potential). FT DOMAIN 431 444 Cytoplasmic (Potential). FT DOMAIN 211 374 Interaction with neurabin II. FT SITE 193 193 Implicated in catechol agonist binding. FT SITE 194 194 Implicated in receptor activation. FT SITE 197 197 Implicated in receptor activation. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT DISULFID 107 182 By similarity. FT VARSPLIC 242 270 Missing (in isoform Short). FT /FTId=VSP_001871. FT MUTAGEN 193 193 S->A: Moderate decrease in ligand FT binding. 200-fold reduction of agonist- FT mediated cAMP inhibition. FT MUTAGEN 194 194 S->A: Small decrease in agonist binding. FT Complete loss of agonist-mediated cAMP FT inhibition. FT MUTAGEN 197 197 S->A: Small decrease in agonist binding. FT 18-fold reduction of agonist-mediated FT cAMP inhibition. FT MUTAGEN 420 420 S->A: Moderate decrease in ligand FT binding. FT CONFLICT 99 99 E -> D (in Ref. 5). FT CONFLICT 173 173 G -> R (in Ref. 5). FT CONFLICT 180 180 N -> G (in Ref. 5). SQ SEQUENCE 444 AA; 50903 MW; 216E56CEE5CA32FB CRC64; MDPLNLSWYD DDLERQNWSR PFNGSEGKAD RPHYNYYAML LTLLIFIIVF GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFMK ILHC // ID A1AA_RAT STANDARD; PRT; 466 AA. AC P43140; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A- DE adrenoreceptor) (Alpha-1C adrenergic receptor). GN ADRA1A OR ADRA1C. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Heart muscle; RX MEDLINE=95008062; PubMed=7923624; RA Stewart A.F., Rokosh D.G., Bailey B.A., Karns L.R., Chang K.C., RA Long C.S., Kariya K., Simpson P.C.; RT "Cloning of the rat alpha 1C-adrenergic receptor from cardiac RT myocytes. Alpha 1C, alpha 1B, and alpha 1D mRNAs are present in RT cardiac myocytes but not in cardiac fibroblasts."; RL Circ. Res. 75:796-802(1994). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=95021119; PubMed=7935320; RA Laz T.M., Forray C., Smith K.E., Bard J.A., Vaysse P.J., RA Branchek T.A., Weinshank R.L.; RT "The rat homologue of the bovine alpha 1c-adrenergic receptor shows RT the pharmacological properties of the classical alpha 1A subtype."; RL Mol. Pharmacol. 46:414-422(1994). CC -!- FUNCTION: This alpha-adrenergic receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. Its effect is mediated by G(q) CC and G(11) proteins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated CC (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U13368; AAA52103.1; -. DR EMBL; U07126; AAA62866.1; -. DR PIR; I57959; I57959. DR RGD; 2055; Adra1a. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00557; ADRENRGCA1AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 51 1 (Potential). FT DOMAIN 52 64 Cytoplasmic (Potential). FT TRANSMEM 65 88 2 (Potential). FT DOMAIN 89 99 Extracellular (Potential). FT TRANSMEM 100 122 3 (Potential). FT DOMAIN 123 143 Cytoplasmic (Potential). FT TRANSMEM 144 167 4 (Potential). FT DOMAIN 168 181 Extracellular (Potential). FT TRANSMEM 182 205 5 (Potential). FT DOMAIN 206 273 Cytoplasmic (Potential). FT TRANSMEM 274 297 6 (Potential). FT DOMAIN 298 305 Extracellular (Potential). FT TRANSMEM 306 329 7 (Potential). FT DOMAIN 330 466 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT DISULFID 99 176 By similarity. FT MOD_RES 215 215 Phosphoserine (by PKA) (Potential). FT LIPID 345 345 S-palmitoyl cysteine (Potential). FT CONFLICT 39 39 F -> L (in Ref. 1). FT CONFLICT 67 67 N -> G (in Ref. 1). SQ SEQUENCE 466 AA; 51597 MW; 4962D3A72E971A36 CRC64; MVLLSENASE GSNCTHPPAP VNISKAILLG VILGGLIIFG VLGNILVILS VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGVRALLCV WVLSLVISIG PLFGWRQPAP EDETICQINE EPGYVLFSAL GSFYVPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN VPAEGGGVSS AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRRQ SSKHALGYTL HPPSQALEGQ HRDMVRIPVG SGETFYKISK TDGVCEWKFF SSMPQGSARI TVPKDQSACT TARVRSKSFL QVCCCVGSSA PRPEENHQVP TIKIHTISLG ENGEEV // ID 5HT_HELVI STANDARD; PRT; 466 AA. AC Q25190; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE 5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor). OS Heliothis virescens (Noctuid moth) (Owlet moth). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; OC Noctuidae; Heliothinae; Heliothis. OX NCBI_TaxID=7102; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Antenna; RX MEDLINE=97166608; PubMed=9014328; RA von Nickisch-Rosenegk E., Krieger J., Kubick S., Laage R., Strobel J., RA Strotmann J., Breer H.; RT "Cloning of biogenic amine receptors from moths (Bombyx mori and RT Heliothis virescens)."; RL Insect Biochem. Mol. Biol. 26:817-827(1996). CC -!- FUNCTION: THIS IS A RECEPTOR FOR 5-HYDROXYTRYPTAMINE (SEROTONIN), CC A BIOGENIC HORMONE THAT FUNCTION AS A NEUROTRANSMITTER, A HORMONE, CC AND A MITOGEN (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X95605; CAA64863.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 66 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 67 89 1 (POTENTIAL). FT DOMAIN 90 99 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 100 121 2 (POTENTIAL). FT DOMAIN 122 136 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 137 158 3 (POTENTIAL). FT DOMAIN 159 177 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 178 200 4 (POTENTIAL). FT DOMAIN 201 228 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 229 250 5 (POTENTIAL). FT DOMAIN 251 386 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 387 410 6 (POTENTIAL). FT DOMAIN 411 419 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 420 442 7 (POTENTIAL). FT DOMAIN 443 466 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 10 10 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 29 29 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 41 41 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 45 45 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 50 50 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 135 215 BY SIMILARITY. SQ SEQUENCE 466 AA; 52094 MW; AD29A38EC37106EB CRC64; MNASRLPGFN DTSQDQPYPT SSEWFDGSNC SWVDAVSWGC NVTINGTSTN ATSTDVTSFV LMAVTSVVLA LIILATIVGN VFVIAAIIIE RNLQNVANYL VASLAVADLM VACLVMPLGA VYEVSQGWIL GPELCDMWTS SDVLCSSASI LHLVAIATDR YWAVTDVDYI HIRNEKRIFT MIVLVWGAAL VVSLAPQLGW KDPDYLARIT QQQKCLVSQD LAYQIFATMS TFYVPLAVIL ILYWKIFQTA RRRIRRRRDP PPPRPTSADG ATPSGRPVQS ARDRRFVKKR FLNLKKCNQR TRAETLAAAL LLTEGQSTST VDTLDEEPRT TAFTINEKVP PSVSPEKSSS TVTNGSKPER AIVPAPTHRE KKESLEAKRE RKAAKTLAII TGAFVFCWLP FFIMALVMPI CQTCVISDYL ASFFLWLGYF NSTLNPVIYT IFSPDFRQAF ARILFGTHRR RRYKKF // ID 5H1D_HUMAN STANDARD; PRT; 377 AA. AC P28221; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 1D receptor (5-HT-1D) (Serotonin receptor 1D) DE (5-HT-1D-alpha). GN HTR1D OR HTR1DA. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91342595; PubMed=1652050; RA Hamblin M.W., Metcalf M.A.; RT "Primary structure and functional characterization of a human 5-HT1D- RT type serotonin receptor."; RL Mol. Pharmacol. 40:143-148(1991). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RX MEDLINE=92228840; PubMed=1565658; RA Weinshank R.L., Zgombick J.M., Macchi M.J., Branchek T.A., RA Hartig P.R.; RT "Human serotonin 1D receptor is encoded by a subfamily of two RT distinct genes: 5-HT1D alpha and 5-HT1D beta."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992). RN [3] RP SEQUENCE FROM N.A. RA Frankland J.; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE FROM N.A. RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Eye; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [6] RP VARIANT LEU-265. RX MEDLINE=99318093; PubMed=10391209; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [7] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Strongest to the other 5HT-1 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M89955; AAA35491.1; -. DR EMBL; M81589; AAA60315.1; -. DR EMBL; AL049576; CAB81617.1; -. DR EMBL; AF498979; AAM21126.1; -. DR EMBL; BC007720; AAH07720.1; -. DR PIR; A53279; A53279. DR HSSP; P08913; 1HLL. DR Genew; HGNC:5289; HTR1D. DR MIM; 182133; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00514; 5HT1DRECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Polymorphism. FT DOMAIN 1 38 Extracellular (Potential). FT TRANSMEM 39 62 1 (Potential). FT DOMAIN 63 75 Cytoplasmic (Potential). FT TRANSMEM 76 98 2 (Potential). FT DOMAIN 99 108 Extracellular (Potential). FT TRANSMEM 109 134 3 (Potential). FT DOMAIN 135 154 Cytoplasmic (Potential). FT TRANSMEM 155 176 4 (Potential). FT DOMAIN 177 194 Extracellular (Potential). FT TRANSMEM 195 218 5 (Potential). FT DOMAIN 219 302 Cytoplasmic (Potential). FT TRANSMEM 303 326 6 (Potential). FT DOMAIN 327 335 Extracellular (Potential). FT TRANSMEM 336 360 7 (Potential). FT DOMAIN 361 377 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT DISULFID 111 188 By similarity. FT VARIANT 265 265 S -> L (in dbSNP:6299). FT /FTId=VAR_011834. SQ SEQUENCE 377 AA; 41906 MW; 0A4FCF81FFE2322A CRC64; MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL ATVLSNAFVL TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI THTWNFGQIL CDIWLSSDIT CCTASILHLC VIALDRYWAI TDALEYSKRR TAGHAATMIA IVWAISICIS IPPLFWRQAK AQEEMSDCLV NTSQISYTIY STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT TAHLITGSAG SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL INPIIYTVFN EEFRQAFQKI VPFRKAS // ID A2AR_LABOS STANDARD; PRT; 432 AA. AC Q91081; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Alpha-2 adrenergic receptor (Alpha-2 adrenoceptor) (Alpha-2 DE adrenoreceptor). OS Labrus ossifagus (Cuckoo wrasse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Labroidei; OC Labridae; Labrus. OX NCBI_TaxID=30800; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94035926; PubMed=7693288; RA Svensson S.P.S., Bailey T.J., Pepperl D.J., Grundstroem N., RA Ala-Uotila S., Scheinin M., Karlsson J.O.G., Regan J.W.; RT "Cloning and expression of a fish alpha 2-adrenoceptor."; RL Br. J. Pharmacol. 110:54-60(1993). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U07743; AAA17386.1; -. DR PIR; I50829; I50829. DR HSSP; P08913; 1HLL. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00560; ADRENRGCA2CR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 32 Extracellular (Potential). FT TRANSMEM 33 57 1 (Potential). FT DOMAIN 58 69 Cytoplasmic (Potential). FT TRANSMEM 70 95 2 (Potential). FT DOMAIN 96 105 Extracellular (Potential). FT TRANSMEM 106 128 3 (Potential). FT DOMAIN 129 149 Cytoplasmic (Potential). FT TRANSMEM 150 172 4 (Potential). FT DOMAIN 173 188 Extracellular (Potential). FT TRANSMEM 189 212 5 (Potential). FT DOMAIN 213 356 Cytoplasmic (Potential). FT TRANSMEM 357 380 6 (Potential). FT DOMAIN 381 393 Extracellular (Potential). FT TRANSMEM 394 413 7 (Potential). FT DOMAIN 414 432 Cytoplasmic (Potential). FT DISULFID 105 183 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 432 AA; 48563 MW; 0A42FAF9849FA8BA CRC64; MDPLNATGMD AFTAIHLNAS WSADSGYSLA AIASIAALVS FLILFTVVGN ILVVIAVLTS RALKAPQNLF LVSLATADIL VATLVMPFSL ANELMGYWYF GKVWCGIYLA LDVLFCTSSI VHLCAISLDR YWSVTQAVEY NLKRTPKRVK CIIVIVWLIS AFISSPPLLS IDSNNYISSQ PQCMLNDDTW YILSSSMASF FAPCLIMILV YIRIYQVAKT RTRSMSGKEP RPDGVTQTEN GLNKANSPCH GDRENGHCQC PPTPSQRTVT IGQQTDDADM DESFSSEGKG HKPQRQDSQR AKRPGLKKSS ISKQSARISR VSNKSVDLFA SRRKRRRSSI AEKKVSQARE KRFTFVLAVV MGVFVVCWFP FFFSYSLHAV CRDYCKIPDT LFKFFWIGYC NSSLNPAIYT IFNRDFRRAF QKILCKSWKK SF // ID ACM2_MOUSE STANDARD; PRT; 466 AA. AC Q9ERZ4; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Muscarinic acetylcholine receptor M2. GN CHRM2 OR CHRM-2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RA Gomeza J., Wess J.; RT "Isolation, sequence and functional expression of mouse muscarinic RT acetylcholine receptor genes."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is adenylate cyclase inhibition. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF264049; AAG14343.1; -. DR MGD; MGI:88397; Chrm2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PRINTS; PR00539; MUSCRINICM2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Postsynaptic membrane; Glycoprotein; Transmembrane; Phosphorylation; KW Multigene family; G-protein coupled receptor. FT DOMAIN 1 22 Extracellular (Potential). FT TRANSMEM 23 45 1 (Potential). FT DOMAIN 46 59 Cytoplasmic (Potential). FT TRANSMEM 60 80 2 (Potential). FT DOMAIN 81 97 Extracellular (Potential). FT TRANSMEM 98 119 3 (Potential). FT DOMAIN 120 139 Cytoplasmic (Potential). FT TRANSMEM 140 162 4 (Potential). FT DOMAIN 163 184 Extracellular (Potential). FT TRANSMEM 185 207 5 (Potential). FT DOMAIN 208 388 Cytoplasmic (Potential). FT TRANSMEM 389 409 6 (Potential). FT DOMAIN 410 423 Extracellular (Potential). FT TRANSMEM 424 443 7 (Potential). FT DOMAIN 444 466 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT DISULFID 96 176 By similarity. FT MOD_RES 446 446 Phosphothreonine (Potential). FT MOD_RES 450 450 Phosphothreonine (Potential). FT MOD_RES 465 465 Phosphothreonine (Potential). SQ SEQUENCE 466 AA; 51515 MW; CDCF281AD28276F8 CRC64; MNNSTNSSNN GLAITSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKE KKEPVANQDP VSPSLVQGRI VKPNNNNMPG GDGGLEHNKI QNGKALRDGG TENCVQGEEK ESSNDSTSVS AVASNMRDDE ITQDENTVST SLGHSKDDNS RQTCIKIVTK TQKGDACTPT STTVELVGSS GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR // ID 5H1D_CANFA STANDARD; PRT; 377 AA. AC P11614; DT 01-OCT-1989 (Rel. 12, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 1D receptor (5-HT-1D) (Serotonin receptor 1D). GN HTR1D OR RDC4. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Thyroid; RX MEDLINE=89242119; PubMed=2541503; RA Libert F., Parmentier M., Lefort A., Dinsart C., van Sande J., RA Maenhaut C., Simons M.-J., Dumont J.E., Vassart G.; RT "Selective amplification and cloning of four new members of the G RT protein-coupled receptor family."; RL Science 244:569-572(1989). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Thyroid; RX MEDLINE=90245610; PubMed=2159630; RA Libert F., Parmentier M., Lefort A., Dumont J.E., Vassart G.; RT "Complete nucleotide sequence of a putative G protein coupled RT receptor: RDC4."; RL Nucleic Acids Res. 18:1916-1916(1990). RN [3] RP FUNCTION. RX MEDLINE=92062181; PubMed=1659418; RA Maenhaut C., van Sande J., Massart C., Dinsart C., Libert F., RA Monferini E., Giraldo E., Ladinsky H., Vassart G., Dumont J.E.; RT "The orphan receptor cDNA RDC4 encodes a 5-HT1D serotonin receptor."; RL Biochem. Biophys. Res. Commun. 180:1460-1468(1991). RN [4] RP FUNCTION. RX MEDLINE=92100052; PubMed=1758439; RA Zgombick J.M., Weinshank R.L., Macchi M., Schechter L.E., RA Branchek T.A., Hartig P.R.; RT "Expression and pharmacological characterization of a canine 5- RT hydroxytryptamine1D receptor subtype."; RL Mol. Pharmacol. 40:1036-1042(1991). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Strongest to the other 5HT-1 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X14049; CAA32207.1; -. DR PIR; B30341; B30341. DR HSSP; P08913; 1HLL. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00514; 5HT1DRECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 38 Extracellular (Potential). FT TRANSMEM 39 62 1 (Potential). FT DOMAIN 63 75 Cytoplasmic (Potential). FT TRANSMEM 76 98 2 (Potential). FT DOMAIN 99 108 Extracellular (Potential). FT TRANSMEM 109 134 3 (Potential). FT DOMAIN 135 154 Cytoplasmic (Potential). FT TRANSMEM 155 176 4 (Potential). FT DOMAIN 177 194 Extracellular (Potential). FT TRANSMEM 195 218 5 (Potential). FT DOMAIN 219 302 Cytoplasmic (Potential). FT TRANSMEM 303 326 6 (Potential). FT DOMAIN 327 335 Extracellular (Potential). FT TRANSMEM 336 360 7 (Potential). FT DOMAIN 361 377 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT DISULFID 111 188 By similarity. SQ SEQUENCE 377 AA; 41882 MW; 8E6406DCE2123EE4 CRC64; MSPPNQSLEG LLQEASNRSL NATETPEAWG PETLQALKIS LALLLSIITM ATALSNAFVL TTIFLTRKLH TPANYLIGSL AMTDLLVSIL VMPISIAYTT TRTWSFGQIL CDIWLSSDIT CCTASILHLC VIALDRYWAI TDALEYSKRR TAGRAAVMIA TVWVISICIS IPPLFWRQAK AQEDMSDCQV NTSQISYTIY STCGAFYIPS VLLIILYGRI YVAARNRILN PPSLYGKRFT TAQLITGSAG SSLCSLSPSL QEERSHAAGP PLFFNHVQVK LAEGVLERKR ISAARERKAT KTLGIILGAF IVCWLPFFVA SLVLPICRAS CWLHPALFDF FTWLGYLNSL INPIIYTVFN EEFRQAFQRV VHVRKAS // ID ACM2_RAT STANDARD; PRT; 466 AA. AC P10980; Q9Z2Z1; DT 01-JUL-1989 (Rel. 11, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Muscarinic acetylcholine receptor M2. GN CHRM2 OR CHRM-2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=88068581; PubMed=2825184; RA Gocayne J.D., Robinson D.A., Fitzgerald M.G., Chung F.-Z., RA Kerlavage A.R., Lentes K.-U., Lai J., Wang C.-D., Fraser C.M., RA Venter J.C.; RT "Primary structure of rat cardiac beta-adrenergic and muscarinic RT cholinergic receptors obtained by automated DNA sequence analysis: RT further evidence for a multigene family."; RL Proc. Natl. Acad. Sci. U.S.A. 84:8296-8300(1987). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Iris; RX MEDLINE=99138467; PubMed=9972520; RA Furuta M., Ohya S., Imaizumi Y., Watanabe M.; RT "Molecular cloning of m3 muscarinic acetylcholine receptor in rat RT iris."; RL J. Smooth Muscle Res. 34:111-122(1998). CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is adenylate cyclase inhibition. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; J03025; AAA40926.1; -. DR EMBL; AB017655; BAA36838.1; -. DR PIR; S10856; S10856. DR RGD; 620023; Chrm2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PRINTS; PR00539; MUSCRINICM2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Postsynaptic membrane; Glycoprotein; Transmembrane; Phosphorylation; KW Multigene family; G-protein coupled receptor. FT DOMAIN 1 22 Extracellular (Potential). FT TRANSMEM 23 45 1 (Potential). FT DOMAIN 46 59 Cytoplasmic (Potential). FT TRANSMEM 60 80 2 (Potential). FT DOMAIN 81 97 Extracellular (Potential). FT TRANSMEM 98 119 3 (Potential). FT DOMAIN 120 139 Cytoplasmic (Potential). FT TRANSMEM 140 162 4 (Potential). FT DOMAIN 163 184 Extracellular (Potential). FT TRANSMEM 185 207 5 (Potential). FT DOMAIN 208 388 Cytoplasmic (Potential). FT TRANSMEM 389 409 6 (Potential). FT DOMAIN 410 423 Extracellular (Potential). FT TRANSMEM 424 443 7 (Potential). FT DOMAIN 444 466 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT DISULFID 96 176 By similarity. FT MOD_RES 446 446 Phosphothreonine (Potential). FT MOD_RES 450 450 Phosphothreonine (Potential). FT MOD_RES 465 465 Phosphothreonine (Potential). FT CONFLICT 51 51 N -> S (in Ref. 1). FT CONFLICT 273 273 N -> T (in Ref. 1). FT CONFLICT 289 290 VS -> SA (in Ref. 1). FT CONFLICT 313 313 G -> D (in Ref. 1). FT CONFLICT 337 337 C -> Y (in Ref. 1). FT CONFLICT 353 353 N -> S (in Ref. 1). FT CONFLICT 360 360 I -> V (in Ref. 1). FT CONFLICT 369 369 T -> P (in Ref. 1). SQ SEQUENCE 466 AA; 51539 MW; 70ECCD86366A676B CRC64; MNNSTNSSNN GLAITSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKE KKEPVANQDP VSPSLVQGRI VKPNNNNMPG GDGGLEHNKI QNGKAPRDGV TENCVQGEEK ESSNDSTSVS AVASNMRDDE ITQDENTVST SLGHSRDDNS KQTCIKIVTK AQKGDVCTPT STTVELVGSS GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR // ID OAR1_LYMST STANDARD; PRT; 638 AA. AC O77408; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE Octopamine receptor 1 (OA1). OS Lymnaea stagnalis (Great pond snail). OC Eukaryota; Metazoa; Mollusca; Gastropoda; Pulmonata; Basommatophora; OC Lymnaeoidea; Lymnaeidae; Lymnaea. OX NCBI_TaxID=6523; RN [1] RP SEQUENCE FROM N.A., AND CHARACTERIZATION. RC TISSUE=CNS; RX MEDLINE=97347296; PubMed=9203635; RA Gerhardt C.C., Bakker R.A., Piek G.J., Planta R.J., Vreugdenhil E., RA Leysen J.E., van Heerikhuizen H.; RT "Molecular cloning and pharmacological characterization of a molluscan RT octopamine receptor."; RL Mol. Pharmacol. 51:293-300(1997). CC -!- FUNCTION: G-PROTEIN COUPLED RECEPTOR FOR OCTOPAMINE (OA), WHICH IS CC A NEUROTRANSMITTER, NEUROHORMONE, AND NEUROMODULATOR IN CC INVERTEBRATES. ACTIVATION OF THIS RECEPTOR BY OCTOPAMINE INDUCES CC AN INCREASE IN BOTH INOSITOL PHOSPHATES AND CYCLIC AMP. THE CC COUPLING TO ADENYLYL CYCLASE SEEMS TO BE LESS EFFICIENT THAN THE CC COUPLING TO PHOSPHOLIPASE C. THE RANK ORDER OF POTENCY FOR CC AGONISTS IS P-SYNEPHRINE >= CLONDINE > P-OCTOPAMINE = CC XYLOMETHAZOLINE = PHENYLEPHRINE = OXYMETAZOLINE > B-HT920 > CC SEROTONIN = P-TYRAMINE > EPINEPHRINE > NOREPINEPHRINE > CC METHOXAMINE = DOPAMINE = HISTAMINE. FOR ANTAGONISTS, THE RANK CC ORDER IS YOHIMBINE > CHLOPROMAZINE / SPIPERONE > PHENTOLAMINE > CC MIANSERINE > RAUWOLSCINE > PRAZOSIN > ALPRENOLOL / PROPANOLOL > CC PINDOLOL. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: EXPRESSED IN THE CENTRAL NERVOUS SYSTEM. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U62771; AAC61296.1; -. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 53 POTENTIAL. FT DOMAIN 54 64 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 65 87 POTENTIAL. FT DOMAIN 88 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 124 POTENTIAL. FT DOMAIN 125 147 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 148 167 POTENTIAL. FT DOMAIN 168 239 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 240 259 POTENTIAL. FT DOMAIN 260 520 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 521 545 POTENTIAL. FT DOMAIN 546 551 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 552 575 POTENTIAL. FT DOMAIN 576 638 CYTOPLASMIC (POTENTIAL). FT DISULFID 101 230 BY SIMILARITY. FT CARBOHYD 178 178 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 207 207 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 215 215 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 638 AA; 70000 MW; 65FA928B5C01D34F CRC64; MSRDIFMKRL RLHLLFDEVA MVTHIVGDVL SSVLLCAVVL LVLVGNTLVV AAVATSRKLR TVTNVFIVNL ACADLLLGVL VLPFSAVNEI KDVWIFGHVW CQVWLAVDVW LCTASILNLC CISLDRYLAI TRPIRYPGLM SAKRAKTLVA GVWLFSFVIC CPPLIGWNDG GDGIMDYNGT TATPIPVTTT QTPVTGRDDV LCDNGFNYST NSNMNTTCTY SGDSSLSTTC ELTNSRGYRI YAALGSFFIP MLVMVFFYLQ IYRAAVKTIS AYAKGELKTK YSVRENGSKT NSVTLRIHRG GRGPSTGSSV YRHGSTYGGS AAGAATREGC GDKDAAGGRR FGRQEMDSHL PVRKCRSSDA SLVTLTGLKC EIIDNGNAKH GPISELIKGR GKSFFWRKEK KRSVGGERES FENSTRNGRS TRAKLCGGRC LAIETDICSS GECSPRTKRI KEHARATQHN SLPVTPSLSS QNEETDAVFV RGTSNSEYKP RRSRLSAHKP GHAMRLHMQK FNREKKAAKT LAIIVGAFIM CWMPFFTIYL VGAFCENCIS PIVFSVAFWL GYCNSAMNPC VYALFSRDFR FAFRKLLTCS CKAWSKNRSF RPQTSDVPAI QLHCATQDDA KSSSDIGPTA SGGNGGYT // ID D1DR_FUGRU STANDARD; PRT; 459 AA. AC P53452; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE D(1)-like dopamine receptor. GN D14. OS Fugu rubripes (Japanese pufferfish) (Takifugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; OC Tetradontoidea; Tetraodontidae; Takifugu. OX NCBI_TaxID=31033; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95309911; PubMed=7789977; RA Machae A.D., Brenner S.; RT "Analysis of the dopamine receptor family in the compact genome of RT the puffer fish Fugu rubripes."; RL Genomics 25:436-446(1995). CC -!- FUNCTION: RECEPTOR FOR DOPAMINE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X80174; CAA56455.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 23 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 24 49 1 (POTENTIAL). FT DOMAIN 50 60 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 61 87 2 (POTENTIAL). FT DOMAIN 88 96 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 97 119 3 (POTENTIAL). FT DOMAIN 120 138 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 139 164 4 (POTENTIAL). FT DOMAIN 165 191 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 192 216 5 (POTENTIAL). FT DOMAIN 217 269 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 270 297 6 (POTENTIAL). FT DOMAIN 298 311 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 312 333 7 (POTENTIAL). FT DOMAIN 334 459 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 96 187 BY SIMILARITY. SQ SEQUENCE 459 AA; 51080 MW; B69857A3A4E4E10B CRC64; MAQNFSTVGD GKQMLLERDS SKRVLTGCFL SLLIFTTLLG NTLVCVAVTK FRHLRSKVTN FFVISLAISD LLVAILVMPW KAATEIMGFW PFGEFCNIWV AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKVA CLMISVAWTL SVLISFIPVQ LNWHKAQTAS YVELNGTYAG DLPPDNCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR IAQKQIRRIS ALERAAESAQ NRHSSMGNSL SMESECSFKM SFKRETKVLK TLSVIMGVFV CCWLPFFILN CMVPFCEADD TTDFPCISST TFDVFVWFGW ANSSLNPIIY AFNADFRKAF SILLGCHRLC PGNSAIEIVS INNTGAPLSN PSCQYQPKSH IPKEGNHSSS YVIPHSILCQ EEELQKKDGF GGEMEVGLVN NAMEKVSPAI SGNFDSDAAV TLETINPITQ NGQHKSMSC // ID B2AR_FELCA STANDARD; PRT; 418 AA. AC Q9TST5; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2 DE adrenoreceptor). GN ADRB2. OS Felis silvestris catus (Cat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Felidae; Felis. OX NCBI_TaxID=9685; RN [1] RP SEQUENCE FROM N.A. RA Cully D.F., Tremml G., Zachwieja S.; RT "Felis domesticus beta adrenergic receptor subtype 2."; RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. The beta-2-adrenergic receptor binds epinephrine with an CC approximately 30-fold greater affinity than it does CC norepinephrine (By similarity). CC -!- SUBUNIT: Binds SLC9A3R1 (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Palmitoylated; may reduce accessibility of Ser-345 and Ser- CC 346 by anchoring Cys-341 to the plasma membrane. Agonist CC stimulation promotes depalmitoylation and further allows Ser-345 CC and Ser-346 phosphorylation (By similarity). CC -!- PTM: Phosphorylated by PKA and BARK; mediate homologous CC desensitization of the receptor. PKA-mediated phosphorylation CC seems to facilitate phosphorylation by BARK (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF192345; AAF04304.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00562; ADRENRGCB2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 34 Extracellular (Potential). FT TRANSMEM 35 58 1 (Potential). FT DOMAIN 59 71 Cytoplasmic (Potential). FT TRANSMEM 72 95 2 (Potential). FT DOMAIN 96 106 Extracellular (Potential). FT TRANSMEM 107 129 3 (Potential). FT DOMAIN 130 150 Cytoplasmic (Potential). FT TRANSMEM 151 174 4 (Potential). FT DOMAIN 175 196 Extracellular (Potential). FT TRANSMEM 197 220 5 (Potential). FT DOMAIN 221 274 Cytoplasmic (Potential). FT TRANSMEM 275 298 6 (Potential). FT DOMAIN 299 305 Extracellular (Potential). FT TRANSMEM 306 329 7 (Potential). FT DOMAIN 330 418 Cytoplasmic (Potential). FT SITE 113 113 IMPLICATED IN CATECHOL AGONIST AND FT ANTAGONIST BINDING (BY SIMILARITY). FT SITE 204 204 Implicated in catechol agonist binding FT (By similarity). FT SITE 207 207 Implicated in catechol agonist binding FT (By similarity). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Probable). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Probable). FT DISULFID 106 184 By similarity. FT LIPID 341 341 S-palmitoyl cysteine (By similarity). FT MOD_RES 262 262 Phosphoserine (by PKA) (Potential). FT MOD_RES 345 345 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 346 346 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 355 355 Phosphoserine (by BARK) (Probable). SQ SEQUENCE 418 AA; 46735 MW; C0D32A6A2C72472B CRC64; MGQPGNRSVF LLAPNGSHAP DQDGTQERND AWVVGMGIVM SLIVLAIVFG NVLVITAIAR FERLQTVTNY FITSLACADL VMGLAVVPFG ASHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVVILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYAKETC CDFFTNQAYA IASSIVSFYL PLVVMVFVYS RVFQVAQRQL QKIDKSEGRF HAQNLSQVEQ DGRSGHGHRR ASKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD NLIPKEVYIL LNWVGYVNSA FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSNNSNS RTDYAGEHSG GPLGQEKDSE VLCEDPPGTE NLANRQGTVP NDSIDSQGQN GSTNDSLL // ID B2AR_CANFA STANDARD; PRT; 415 AA. AC P54833; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2 DE adrenoreceptor). GN ADRB2. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Heart muscle; RX MEDLINE=97034778; PubMed=8880434; RA Emala C.W., Kuhl J., Hirshman C.A., Levine M.A.; RT "Rapid communication: cloning and sequencing of a canine beta 2- RT adrenergic receptor cDNA."; RL J. Anim. Sci. 74:2285-2286(1996). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=97364078; PubMed=9220370; RA Huang R.-R.C., Rapoport D., Schaeffer M.-T., Cascieri M.A., RA Fong T.M.; RT "Molecular cloning of the dog beta 1 and beta 2 adrenergic RT receptors."; RL J. Recept. Signal Transduct. Res. 17:599-607(1997). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. The beta-2-adrenergic receptor binds epinephrine with an CC approximately 30-fold greater affinity than it does CC norepinephrine. CC -!- SUBUNIT: Binds SLC9A3R1 (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Palmitoylated; may reduce accessibility of Ser-345 and Ser- CC 346 by anchoring Cys-341 to the plasma membrane. Agonist CC stimulation promotes depalmitoylation and further allows Ser-345 CC and Ser-346 phosphorylation (By similarity). CC -!- PTM: Phosphorylated by PKA and BARK; mediate homologous CC desensitization of the receptor. PKA-mediated phosphorylation CC seems to facilitate phosphorylation by BARK (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X94608; CAA64316.1; -. DR EMBL; U73206; AAB93647.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00562; ADRENRGCB2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 34 Extracellular (Potential). FT TRANSMEM 35 58 1 (Potential). FT DOMAIN 59 71 Cytoplasmic (Potential). FT TRANSMEM 72 95 2 (Potential). FT DOMAIN 96 106 Extracellular (Potential). FT TRANSMEM 107 129 3 (Potential). FT DOMAIN 130 150 Cytoplasmic (Potential). FT TRANSMEM 151 174 4 (Potential). FT DOMAIN 175 196 Extracellular (Potential). FT TRANSMEM 197 220 5 (Potential). FT DOMAIN 221 274 Cytoplasmic (Potential). FT TRANSMEM 275 298 6 (Potential). FT DOMAIN 299 305 Extracellular (Potential). FT TRANSMEM 306 329 7 (Potential). FT DOMAIN 330 415 Cytoplasmic (Potential). FT SITE 113 113 IMPLICATED IN CATECHOL AGONIST AND FT ANTAGONIST BINDING (BY SIMILARITY). FT SITE 204 204 Implicated in catechol agonist binding FT (By similarity). FT SITE 207 207 Implicated in catechol agonist binding FT (By similarity). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Probable). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Probable). FT DISULFID 106 184 By similarity. FT LIPID 341 341 S-palmitoyl cysteine. FT MOD_RES 261 261 Phosphoserine (by PKA) (Potential). FT MOD_RES 262 262 Phosphoserine (by PKA) (Potential). FT MOD_RES 345 345 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 346 346 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 355 355 Phosphoserine (by BARK) (Probable). SQ SEQUENCE 415 AA; 46588 MW; 392588623833445E CRC64; MGQPANRSVF LLAPNGSHAP DQGDSQERSE AWVVGMGIVM SLIVLAIVFG NVLVITAIAR FERLQTVTNY FITSLACADL VMGLAVVPFG ASHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVVILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYAKETC CDFFTNQAYA IASSIVSFYL PLVVMVFVYS RVFQVAQRQL QKIDRSEGRF HAQNLSQVEQ DGRSGHGHRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD NLIPKEVYIL LNWVGYVNSA FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSNNSNS RSDYAGEHSG CHLGQEKDSE LLCEDPPGTE DRQGTVPSDS VDSQGRNCST NDSLL // ID 5H7_MOUSE STANDARD; PRT; 448 AA. AC P32304; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 7 receptor (5-HT-7) (Serotonin receptor 7) (5-HT- DE X) (5HT7). GN HTR7. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93360913; PubMed=8394987; RA Plassat J.-L., Amlaiky N., Hen R.; RT "Molecular cloning of a mammalian serotonin receptor that activates RT adenylate cyclase."; RL Mol. Pharmacol. 44:229-236(1993). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that stimulate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Z23107; CAA80654.1; -. DR PIR; I48779; S36402. DR MGD; MGI:99841; Htr7. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00652; 5HT7RECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 84 Extracellular (Potential). FT TRANSMEM 85 111 1 (Potential). FT DOMAIN 112 121 Cytoplasmic (Potential). FT TRANSMEM 122 147 2 (Potential). FT DOMAIN 148 159 Extracellular (Potential). FT TRANSMEM 160 181 3 (Potential). FT DOMAIN 182 201 Cytoplasmic (Potential). FT TRANSMEM 202 225 4 (Potential). FT DOMAIN 226 240 Extracellular (Potential). FT TRANSMEM 241 263 5 (Potential). FT DOMAIN 264 331 Cytoplasmic (Potential). FT TRANSMEM 332 355 6 (Potential). FT DOMAIN 356 367 Extracellular (Potential). FT TRANSMEM 368 390 7 (Potential). FT DOMAIN 391 448 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 69 69 N-linked (GlcNAc...) (Potential). FT DISULFID 158 234 By similarity. FT LIPID 404 404 S-palmitoyl cysteine (Potential). SQ SEQUENCE 448 AA; 49861 MW; 01C7380300991C30 CRC64; MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA GNCLVVISVC FVKNVRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK CMAKMILSVW PLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK EVEECANLSR LLKHERKNIS SFKREQKAAT TLGIIVGAFT VCWLPFFLLS TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYSFF NRDLRTTYRS LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT // ID B2AR_MESAU STANDARD; PRT; 418 AA. AC P04274; DT 20-MAR-1987 (Rel. 04, Created) DT 20-MAR-1987 (Rel. 04, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2 DE adrenoreceptor). GN ADRB2. OS Mesocricetus auratus (Golden hamster). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Cricetinae; OC Mesocricetus. OX NCBI_TaxID=10036; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=86203654; PubMed=3010132; RA Dixon R.A.F., Kobilka B.K., Strader D.J., Benovic J.L., Dohlman H.G., RA Frielle T., Bolanowski M.A., Bennett C.D., Rands E., Diehl R.E., RA Mumford R.A., Slater E.E., Sigal I.S., Caron M.G., Lefkowitz R.J., RA Strader C.D.; RT "Cloning of the gene and cDNA for mammalian beta-adrenergic receptor RT and homology with rhodopsin."; RL Nature 321:75-79(1986). RN [2] RP MUTAGENESIS TO CONFIRM GLYCOSYLATION SITES. RX MEDLINE=90285215; PubMed=2162359; RA Rands E., Candelore M.R., Cheung A.H., Will W.S., Strader C.D., RA Dixon R.A.F.; RT "Mutational analysis of beta-adrenergic receptor glycosylation."; RL J. Biol. Chem. 265:10759-10764(1990). RN [3] RP MUTAGENESIS OF SER-204 AND SER-207. RX MEDLINE=89340434; PubMed=2547766; RA Strader C.D., Candelore M.R., Hill W.S., Sigal I.S., Dixon R.A.F.; RT "Identification of two serine residues involved in agonist activation RT of the beta-adrenergic receptor."; RL J. Biol. Chem. 264:13572-13578(1989). RN [4] RP MUTAGENESIS OF ASP-79 AND ASP-113. RX MEDLINE=88273123; PubMed=2899076; RA Strader C.D., Sigal I.S., Candelore M.R., Rands E., Hill W.S., RA Dixon R.A.F.; RT "Conserved aspartic acid residues 79 and 113 of the beta-adrenergic RT receptor have different roles in receptor function."; RL J. Biol. Chem. 263:10267-10271(1988). RN [5] RP 3D-STRUCTURE MODELING. RX MEDLINE=92292166; PubMed=1318386; RA Huss K.M., Lybrand T.P.; RT "Three-dimensional structure for the beta 2 adrenergic receptor RT protein based on computer modeling studies."; RL J. Mol. Biol. 225:859-871(1992). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. The beta-2-adrenergic receptor binds epinephrine with an CC approximately 30-fold greater affinity than it does CC norepinephrine. CC -!- SUBUNIT: Binds SLC9A3R1 (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Palmitoylated; may reduce accessibility of Ser-345 and Ser- CC 346 by anchoring Cys-341 to the plasma membrane. Agonist CC stimulation promotes depalmitoylation and further allows Ser-345 CC and Ser-346 phosphorylation (By similarity). CC -!- PTM: Phosphorylated by PKA and BARK; mediate homologous CC desensitization of the receptor. PKA-mediated phosphorylation CC seems to facilitate phosphorylation by BARK (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X03804; CAA27430.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00562; ADRENRGCB2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 34 Extracellular (Potential). FT TRANSMEM 35 58 1 (Potential). FT DOMAIN 59 71 Cytoplasmic (Potential). FT TRANSMEM 72 95 2 (Potential). FT DOMAIN 96 106 Extracellular (Potential). FT TRANSMEM 107 129 3 (Potential). FT DOMAIN 130 150 Cytoplasmic (Potential). FT TRANSMEM 151 174 4 (Potential). FT DOMAIN 175 196 Extracellular (Potential). FT TRANSMEM 197 220 5 (Potential). FT DOMAIN 221 274 Cytoplasmic (Potential). FT TRANSMEM 275 298 6 (Potential). FT DOMAIN 299 305 Extracellular (Potential). FT TRANSMEM 306 329 7 (Potential). FT DOMAIN 330 418 Cytoplasmic (Potential). FT SITE 113 113 IMPLICATED IN CATECHOL AGONIST AND FT ANTAGONIST BINDING. FT SITE 204 204 Implicated in catechol agonist binding. FT SITE 207 207 Implicated in catechol agonist binding. FT CARBOHYD 6 6 N-linked (GlcNAc...). FT CARBOHYD 15 15 N-linked (GlcNAc...). FT DISULFID 106 184 By similarity. FT LIPID 341 341 S-palmitoyl cysteine (By similarity). FT MOD_RES 261 261 Phosphoserine (by PKA) (Potential). FT MOD_RES 262 262 Phosphoserine (by PKA) (Potential). FT MOD_RES 345 345 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 346 346 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 355 355 Phosphoserine (by BARK) (Probable). FT MOD_RES 356 356 Phosphoserine (by BARK) (Probable). FT MUTAGEN 79 79 D->A: Small decrease in agonist binding. FT No effect on antagonist binding. FT MUTAGEN 113 113 D->A: Drastic decrease in agonist and FT antagonist binding. Stimulates adenylyl FT cyclase activity. FT MUTAGEN 204 204 S->A: Decrease in catechol agonist FT binding. FT MUTAGEN 207 207 S->A: Decrease in catechol agonist FT binding. SQ SEQUENCE 418 AA; 46861 MW; 9B20478F91FB284E CRC64; MGPPGNDSDF LLTTNGSHVP DHDVTEERDE AWVVGMAILM SVIVLAIVFG NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG ASHILMKMWN FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYIAITSPFK YQSLLTKNKA RMVILMVWIV SGLTSFLPIQ MHWYRATHQK AIDCYHKETC CDFFTNQAYA IASSIVSFYV PLVVMVFVYS RVFQVAKRQL QKIDKSEGRF HSPNLGQVEQ DGRSGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD NLIPKEVYIL LNWLGYVNSA FNPLIYCRSP DFRIAFQELL CLRRSSSKAY GNGYSSNSNG KTDYMGEASG CQLGQEKESE RLCEDPPGTE SFVNCQGTVP SLSLDSQGRN CSTNDSPL // ID HH1R_PANTR STANDARD; PRT; 487 AA. AC Q9N2B2; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Histamine H1 receptor. GN HRH1. OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP SEQUENCE FROM N.A. RA Kitano T., Kobayakawa H., Saitou N.; RT "Silver project."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: In peripheral tissues, the H1 subclass of histamine CC receptors mediates the contraction of smooth muscles, increase in CC capillary permeability due to contraction of terminal venules, and CC catecholamine release from adrenal medulla, as well as mediating CC neurotransmission in the central nervous system (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Potential sites of phosphorylation in the third cytoplasmic CC loop may play an important role in regulating signal transduction CC through the receptor molecule (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB041381; BAA94466.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00530; HISTAMINEH1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate; Phosphorylation. FT DOMAIN 1 29 Extracellular (Potential). FT TRANSMEM 30 49 1 (Potential). FT DOMAIN 50 63 Cytoplasmic (Potential). FT TRANSMEM 64 83 2 (Potential). FT DOMAIN 84 101 Extracellular (Potential). FT TRANSMEM 102 123 3 (Potential). FT DOMAIN 124 145 Cytoplasmic (Potential). FT TRANSMEM 146 165 4 (Potential). FT DOMAIN 166 189 Extracellular (Potential). FT TRANSMEM 190 210 5 (Potential). FT DOMAIN 211 418 Cytoplasmic (Potential). FT TRANSMEM 419 438 6 (Potential). FT DOMAIN 439 450 Extracellular (Potential). FT TRANSMEM 451 470 7 (Potential). FT DOMAIN 471 487 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT DISULFID 100 180 By similarity. FT LIPID 445 445 S-palmitoyl cysteine (Potential). SQ SEQUENCE 487 AA; 55634 MW; 1BCDAAC8450C0527 CRC64; MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLKYRT KTRASATILG AWFLSFLWVI PILGWNHFMQ QTSVRREDKC ETDFYDVTWF KVMTAIINFY LPTLLMLWFY AKIYKAVRQH CQHRELINGS LPSFSEIKLR PENPKGDAKK PGKESPWEVL KRKPKDAGGG SVLKSPSQTX KEMKSPVVFS QEDDREVDKL HCFPLDIVPM QTAAEGSSRD YVAVNQSHGQ LKTDEQGLNT HGASEISEDQ MLGDSQSFSR TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ YVSGLHMNRE RKAAKQLGFI MAAFILCWIP YFIFFMVIAF CKNCCNEHLH MFTIWLGYIN STLNPLIYPL CNENFKKTFK RILHIRS // ID 5H2A_CRIGR STANDARD; PRT; 471 AA. AC P18599; DT 01-NOV-1990 (Rel. 16, Created) DT 01-NOV-1990 (Rel. 16, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 2A receptor (5-HT-2A) (Serotonin receptor 2A) DE (5-HT-2). GN HTR2A. OS Cricetulus griseus (Chinese hamster). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Cricetinae; OC Cricetulus. OX NCBI_TaxID=10029; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=90384833; PubMed=2402449; RA Chambard J.-C., van Obberghen-Schilling E., Haslam R.J., Vouret V., RA Pouyssegur J.; RT "Chinese hamster serotonin (5-HT) type 2 receptor cDNA sequence."; RL Nucleic Acids Res. 18:5282-5282(1990). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. This receptor CC mediates its action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. This CC receptor is involved in tracheal smooth muscle contraction, CC bronchoconstriction, and control of aldosterone production. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of g-protein coupled receptors. CC Strongest to the other 5HT-2 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X53791; CAA37800.1; -. DR PIR; S11280; S11280. DR HSSP; P08913; 1HLL. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00516; 5HT2ARECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 75 Extracellular (Potential). FT TRANSMEM 76 99 1 (Potential). FT DOMAIN 100 110 Cytoplasmic (Potential). FT TRANSMEM 111 132 2 (Potential). FT DOMAIN 133 147 Extracellular (Potential). FT TRANSMEM 148 171 3 (Potential). FT DOMAIN 172 191 Cytoplasmic (Potential). FT TRANSMEM 192 215 4 (Potential). FT DOMAIN 216 233 Extracellular (Potential). FT TRANSMEM 234 254 5 (Potential). FT DOMAIN 255 324 Cytoplasmic (Potential). FT TRANSMEM 325 346 6 (Potential). FT DOMAIN 347 362 Extracellular (Potential). FT TRANSMEM 363 384 7 (Potential). FT DOMAIN 385 471 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). FT CARBOHYD 44 44 N-linked (GlcNAc...) (Potential). FT CARBOHYD 51 51 N-linked (GlcNAc...) (Potential). FT CARBOHYD 54 54 N-linked (GlcNAc...) (Potential). FT DISULFID 148 227 By similarity. SQ SEQUENCE 471 AA; 52702 MW; A05242652039B869 CRC64; MEILCEDNTS LSSIPNSLMQ VDGDSGLYRN DFNSRDANSS DASNWTIDGE NRTNLSFEGY LPPTCLSILH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW TISVGVSMPI PVFGLQDDSK VFKQGSCLLA DDNFVLIGSF VAFFIPLTIM VITYFLTIKS LQKEATLCVS DLSTRAKLAS FSFLPQSSLS SEKLFQRSIH REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEHVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENRKPLQLIL VNTIPALAYK SSQLQAGQNK DSKEDAEPTD NDCSMVTLGK QQSEETCTDN INTVNEKVSC V // ID 5H2C_HUMAN STANDARD; PRT; 458 AA. AC P28335; Q9NP28; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 2C receptor (5-HT-2C) (Serotonin receptor 2C) DE (5HT-1C). GN HTR2C OR HTR1C. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=92109767; PubMed=1722404; RA Saltzman A.G., Morse B., Whitman M.M., Ivanshchenko Y., Jaye M., RA Felder S.; RT "Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes."; RL Biochem. Biophys. Res. Commun. 181:1469-1478(1991). RN [2] RP SEQUENCE FROM N.A., AND FUNCTION. RC TISSUE=Hippocampus, and Placenta; RX MEDLINE=95203331; PubMed=7895773; RA Stam N.J., Vanderheyden P., Van Alebeek C., Klomp J., De Boer T., RA Van Delft A.M.L., Olijve W.; RT "Genomic organisation and functional expression of the gene encoding RT the human serotonin 5-HT2C receptor."; RL Eur. J. Pharmacol. 269:339-348(1994). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=97001158; PubMed=8812491; RA Xie E., Zhao L., Levine A.J., Shenk T., Chang L.-S.; RT "The human serotonin 5-HT2C receptor: complete cDNA, genomic RT structure, and alternatively spliced variant."; RL Genomics 35:551-561(1996). RN [4] RP SEQUENCE FROM N.A., AND RNA EDITING OF POSITIONS 156; 158 AND 160. RC TISSUE=Brain; RX MEDLINE=99127198; PubMed=9928237; RA Niswender C.M., Sanders-Bush E., Emeson R.B.; RT "Identification and characterization of RNA editing events within the RT 5-HT2C receptor."; RL Ann. N. Y. Acad. Sci. 861:38-48(1998). RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE OF 1-116 FROM N.A. RA Kalicki J., Mead K.; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. RN [7] RP VARIANT SER-23. RX MEDLINE=96044432; PubMed=7557992; RA Lappalainen J., Zhang L., Dean M., Oz M., Ozaki N., Yu D., RA Virkkunen M., Weight F., Linnoila M., Goldman D.; RT "Identification, expression, and pharmacology of a Cys23-Ser23 RT substitution in the human 5-HT2c receptor gene (HTR2C)."; RL Genomics 27:274-279(1995). RN [8] RP VARIANT SER-23. RX MEDLINE=99221071; PubMed=10206230; RA Samochowiec J., Smolka M., Winterer G., Rommelspacher H., RA Schmidt L.G., Sander T.; RT "Association analysis between a Cys23Ser substitution polymorphism of RT the human 5-HT2c receptor gene and neuronal hyperexcitability."; RL Am. J. Med. Genet. 88:126-130(1999). RN [9] RP VARIANT SER-23. RX MEDLINE=20049881; PubMed=10581480; RA Marshall S.E., Bird T.G., Hart K., Welsh K.I.; RT "Unified approach to the analysis of genetic variation in serotonergic RT pathways."; RL Am. J. Med. Genet. 88:621-627(1999). RN [10] RP VARIANT SER-23. RX MEDLINE=99318093; PubMed=10391209; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [11] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. This receptor CC mediates its action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- RNA EDITING: Modified_positions=156, 158, 160; Note=Partially CC edited. RNA editing generates receptor isoforms that differ in CC their ability to interact with the phospholipase C signaling CC cascade in a transfected cell line, suggesting that this RNA CC processing event may contribute to the modulation of serotonergic CC neurotransmission in the central nervous system. CC -!- POLYMORPHISM: Position 23 is polymorphic; the frequencies in CC unrelated Caucasians are 0.87 for Cys and 0.13 for Ser. CC -!- SIMILARITY: Belongs to family 1 of g-protein coupled receptors. CC Strongest to the other 5HT-2 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M81778; AAA60317.1; -. DR EMBL; X80763; CAB59978.1; -. DR EMBL; U49516; AAB40898.1; -. DR EMBL; AF208053; AAF35842.1; -. DR EMBL; AF498983; AAM21130.1; -. DR EMBL; AC004822; AAC71658.1; -. DR PIR; JS0616; JS0616. DR HSSP; P08913; 1HLL. DR Genew; HGNC:5295; HTR2C. DR MIM; 312861; -. DR GO; GO:0007631; P:feeding behavior; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00517; 5HT2CRECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Polymorphism; KW Multigene family; RNA editing. FT DOMAIN 1 52 Extracellular (Potential). FT TRANSMEM 53 78 1 (Potential). FT DOMAIN 79 89 Cytoplasmic (Potential). FT TRANSMEM 90 110 2 (Potential). FT DOMAIN 111 127 Extracellular (Potential). FT TRANSMEM 128 150 3 (Potential). FT DOMAIN 151 170 Cytoplasmic (Potential). FT TRANSMEM 171 193 4 (Potential). FT DOMAIN 194 213 Extracellular (Potential). FT TRANSMEM 214 235 5 (Potential). FT DOMAIN 236 311 Cytoplasmic (Potential). FT TRANSMEM 312 333 6 (Potential). FT DOMAIN 334 348 Extracellular (Potential). FT TRANSMEM 349 371 7 (Potential). FT DOMAIN 372 458 Cytoplasmic (Potential). FT CARBOHYD 39 39 N-linked (GlcNAc...) (Potential). FT DISULFID 127 207 By similarity. FT VARIANT 23 23 C -> S (in dbSNP:6318). FT /FTId=VAR_003450. FT VARIANT 156 156 I -> V (in RNA edited version). FT /FTId=VAR_010166. FT VARIANT 158 158 N -> S (in RNA edited version). FT /FTId=VAR_010167. FT VARIANT 160 160 I -> V (in RNA edited version). FT /FTId=VAR_010168. SQ SEQUENCE 458 AA; 51821 MW; 9E76B3FFD3E09C93 CRC64; MVNLRNAVHS FLVHLIGLLV WQCDISVSPV AAIVTDIFNT SDGGRFKFPD GVQNWPALSI VIIIIMTIGG NILVIMAVSM EKKLHNATNY FLMSLAIADM LVGLLVMPLS LLAILYDYVW PLPRYLCPVW ISLDVLFSTA SIMHLCAISL DRYVAIRNPI EHSRFNSRTK AIMKIAIVWA ISIGVSVPIP VIGLRDEEKV FVNNTTCVLN DPNFVLIGSF VAFFIPLTIM VITYCLTIYV LRRQALMLLH GHTEEPPGLS LDFLKCCKRN TAEEENSANP NQDQNARRRK KKERRPRGTM QAINNERKAS KVLGIVFFVF LIMWCPFFIT NILSVLCEKS CNQKLMEKLL NVFVWIGYVC SGINPLVYTL FNKIYRRAFS NYLRCNYKVE KKPPVRQIPR VAATALSGRE LNVNIYRHTN EPVIEKASDN EPGIEMQVEN LELPVNPSSV VSERISSV // ID 5H4_HUMAN STANDARD; PRT; 388 AA. AC Q13639; Q96KH9; Q96KI0; Q9H199; Q9NY73; Q9UBM6; Q9UBT4; Q9UE22; AC Q9UE23; Q9UQR6; DT 01-NOV-1997 (Rel. 35, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 4 receptor (5-HT-4) (Serotonin receptor 4) (5- DE HT4). GN HTR4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORMS 5-HT4(A); 5-HT4(B); 5-HT4(C) AND RP 5-HT4(D)). RC TISSUE=Gut; RX MEDLINE=98264328; PubMed=9603189; RA Blondel O., Gastineau M., Dahmoune Y., Langlois M., Fischmeister R.; RT "Cloning, expression, and pharmacology of four human 5- RT hydroxytryptamine 4 receptor isoforms produced by alternative splicing RT in the carboxyl terminus."; RL J. Neurochem. 70:2252-2261(1998). RN [2] RP SEQUENCE FROM N.A. (ISOFORMS 5-HT4(A) AND 5HT4(B)). RC TISSUE=Brain; RA Van den Wyngaert I., Gommeren W., Jurzak M., Verhasselt P., Gordon R., RA Leysen J., Luyten W., Bender E.; RT "Cloning and expression of 5-HT4 receptor species and splice RT variants."; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. (ISOFORM 5-HT4(A)). RC TISSUE=Heart; RX MEDLINE=98012006; PubMed=9351641; RA Claeysen S., Faye P., Sebben M., Lemaire S., Bockaert J., Dumuis A.; RT "Cloning and expression of human 5-HT4S receptors. Effect of receptor RT density on their coupling to adenylyl cyclase."; RL NeuroReport 8:3189-3195(1997). RN [4] RP SEQUENCE FROM N.A. (ISOFORM 5-HT4(E)). RC TISSUE=Brain; RX MEDLINE=99238795; PubMed=10220570; RA Claeysen S., Sebben M., Becamel C., Bockaert J., Dumuis A.; RT "Novel brain-specific 5-HT4 receptor splice variants show marked RT constitutive activity: role of the C-terminal intracellular domain."; RL Mol. Pharmacol. 55:910-920(1999). RN [5] RP SEQUENCE FROM N.A. (ISOFORMS 5-HT4(A); 5-HT4(E) AND 5-HT4(G)). RC TISSUE=Hippocampus; RA Vilaro M.T., Domenech T., Palacios J.M., Mengod G.; RT "Cloning and characterization of multiple human 5-HT4 receptor RT variants including a novel variant that lacks the alternatively RT spliced C-terminal exon."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE OF 10-388 FROM N.A. (ISOFORM 5-HT4(F)). RX MEDLINE=20110418; PubMed=10646498; RA Bender E., Pindon A., van Oers I., Zhang Y.B., Gommeren W., RA Verhasselt P., Jurzak M., Leysen J., Luyten W.; RT "Structure of the human serotonin 5-HT4 receptor gene and cloning of a RT novel 5-HT4 splice variant."; RL J. Neurochem. 74:478-489(2000). RN [7] RP SEQUENCE OF 112-255 FROM N.A. RC TISSUE=Brain; RX MEDLINE=95385798; PubMed=7656980; RA Ullmer C., Schmuck K., Kalkman H.O., Lubbert H.; RT "Expression of serotonin receptor mRNAs in blood vessels."; RL FEBS Lett. 370:215-221(1995). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that stimulate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=7; CC Comment=Additional isoforms seem to exist; CC Name=5-HT4(B); CC IsoId=Q13639-1; Sequence=Displayed; CC Name=5-HT4(A); Synonyms=5-HT4S; CC IsoId=Q13639-2; Sequence=VSP_001849; CC Name=5-HT4(C); CC IsoId=Q13639-3; Sequence=VSP_001848; CC Name=5-HT4(D); CC IsoId=Q13639-4; Sequence=VSP_001847; CC Name=5-HT4(E); Synonyms=H5-HT4(g); CC IsoId=Q13639-5; Sequence=VSP_001846; CC Name=5-HT4(F); CC IsoId=Q13639-6; Sequence=VSP_001845; CC Name=5-HT4(G); CC IsoId=Q13639-7; Sequence=VSP_001850; CC -!- TISSUE SPECIFICITY: Isoform 5-HT4(A) is expressed in ileum, brain, CC and atrium, but not in the ventricle. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y12505; CAA73107.1; -. DR EMBL; Y12506; CAA73108.1; -. DR EMBL; Y12507; CAA73109.1; -. DR EMBL; Y10437; CAA71462.1; -. DR EMBL; Y08756; CAA70002.1; -. DR EMBL; Y09586; CAA70774.1; -. DR EMBL; Y13584; CAA73911.1; -. DR EMBL; AJ011371; CAA09600.1; -. DR EMBL; AJ243213; CAB71316.1; -. DR EMBL; AJ278979; CAC22248.1; -. DR EMBL; AJ278981; CAC22250.1; -. DR EMBL; AJ278982; CAC22251.1; -. DR EMBL; Z48150; CAA88167.1; -. DR PIR; S66493; S66493. DR HSSP; P08913; 1HLL. DR Genew; HGNC:5299; HTR4. DR MIM; 602164; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate; Alternative splicing. FT DOMAIN 1 19 Extracellular (Potential). FT TRANSMEM 20 40 1 (Potential). FT DOMAIN 41 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT DOMAIN 80 93 Extracellular (Potential). FT TRANSMEM 94 116 3 (Potential). FT DOMAIN 117 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 4 (Potential). FT DOMAIN 159 192 Extracellular (Potential). FT TRANSMEM 193 213 5 (Potential). FT DOMAIN 214 260 Cytoplasmic (Potential). FT TRANSMEM 261 281 6 (Potential). FT DOMAIN 282 294 Extracellular (Potential). FT TRANSMEM 295 315 7 (Potential). FT DOMAIN 316 388 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT DISULFID 93 184 By similarity. FT LIPID 329 329 S-palmitoyl cysteine (By similarity). FT VARSPLIC 169 169 L -> LERSLNQGLGQDFHA (in isoform FT 5-HT4(F)). FT /FTId=VSP_001845. FT VARSPLIC 359 388 RDAVECGGQWESQCHPPATSPLVAAQPSDT -> SGCSPVS FT SFLLLFCNRPVPV (in isoform 5-HT4(E)). FT /FTId=VSP_001846. FT VARSPLIC 359 388 RDAVECGGQWESQCHPPATSPLVAAQPSDT -> SSGTETD FT RRNFGIRKRRLTKPS (in isoform 5-HT4(D)). FT /FTId=VSP_001847. FT VARSPLIC 360 388 DAVECGGQWESQCHPPATSPLVAAQPSDT -> F (in FT isoform 5-HT4(C)). FT /FTId=VSP_001848. FT VARSPLIC 360 388 DAVECGGQWESQCHPPATSPLVAAQPSDT -> YTVLHRGH FT HQELEKLPIHNDPESLESCF (in isoform FT 5-HT4(A)). FT /FTId=VSP_001849. FT VARSPLIC 360 388 Missing (in isoform 5-HT4(G)). FT /FTId=VSP_001850. SQ SEQUENCE 388 AA; 43761 MW; 7FCFEC60E7BDF560 CRC64; MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD AVECGGQWES QCHPPATSPL VAAQPSDT // ID 5H6_HUMAN STANDARD; PRT; 440 AA. AC P50406; Q13640; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 6 receptor (5-HT-6) (Serotonin receptor 6). GN HTR6. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Striatum; RX MEDLINE=96102917; PubMed=8522988; RA Kohen R., Metcalf M.A., Khan N., Druck T., Huebner K., Lachowicz J.E., RA Sibley D.R., Roth B., Hamblin M.W.; RT "Cloning, characterization, and chromosomal localization of a human RT 5-HT6 serotonin receptor."; RL J. Neurochem. 66:47-56(1996). RN [2] RP SEQUENCE OF 215-280 FROM N.A. RC TISSUE=Striatum; RX MEDLINE=95385798; PubMed=7656980; RA Ullmer C., Schmuck K., Kalkman H.O., Lubbert H.; RT "Expression of serotonin receptor mRNAs in blood vessels."; RL FEBS Lett. 370:215-221(1995). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that stimulate adenylate CC cyclase. It has a high affinity for tricyclic psychotropic drugs. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in several human brain regions, most CC prominently in the caudate nucleus. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L41147; AAA92622.1; -. DR EMBL; Z49119; CAA88929.1; -. DR PIR; JC5520; JC5520. DR HSSP; P08913; 1HLL. DR Genew; HGNC:5301; HTR6. DR MIM; 601109; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004969; F:histamine receptor activity; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 34 Extracellular (Potential). FT TRANSMEM 35 57 1 (Potential). FT DOMAIN 58 64 Cytoplasmic (Potential). FT TRANSMEM 65 85 2 (Potential). FT DOMAIN 86 100 Extracellular (Potential). FT TRANSMEM 101 122 3 (Potential). FT DOMAIN 123 144 Cytoplasmic (Potential). FT TRANSMEM 145 166 4 (Potential). FT DOMAIN 167 184 Extracellular (Potential). FT TRANSMEM 185 208 5 (Potential). FT DOMAIN 209 265 Cytoplasmic (Potential). FT TRANSMEM 266 290 6 (Potential). FT DOMAIN 291 295 Extracellular (Potential). FT TRANSMEM 296 320 7 (Potential). FT DOMAIN 321 440 Cytoplasmic (Potential). FT DISULFID 99 180 By similarity. FT CONFLICT 247 247 V -> M (in Ref. 2). SQ SEQUENCE 440 AA; 46954 MW; C888F47650C1D2EF CRC64; MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN // ID 5H5A_HUMAN STANDARD; PRT; 357 AA. AC P47898; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 5A receptor (5-HT-5A) (Serotonin receptor 5A) DE (5-HT-5). GN HTR5A. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95080386; PubMed=7988681; RA Rees S., den Daas I., Foord S., Goodson S., Bull D., Kilpatrick G., RA Lee M.; RT "Cloning and characterisation of the human 5-HT5A serotonin RT receptor."; RL FEBS Lett. 355:242-246(1994). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC STRONGEST TO THE OTHER 5HT-5 SUBTYPE RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X81411; CAA57168.1; -. DR EMBL; X81412; CAA57168.1; JOINED. DR EMBL; AF498985; AAM21132.1; -. DR PIR; I37107; I37107. DR HSSP; P08913; 1HLL. DR Genew; HGNC:5300; HTR5A. DR MIM; 601305; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00518; 5HT5ARECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 40 Extracellular (Potential). FT TRANSMEM 41 63 1 (Potential). FT DOMAIN 64 78 Cytoplasmic (Potential). FT TRANSMEM 79 99 2 (Potential). FT DOMAIN 100 115 Extracellular (Potential). FT TRANSMEM 116 137 3 (Potential). FT DOMAIN 138 158 Cytoplasmic (Potential). FT TRANSMEM 159 181 4 (Potential). FT DOMAIN 182 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 282 Cytoplasmic (Potential). FT TRANSMEM 283 303 6 (Potential). FT DOMAIN 304 320 Extracellular (Potential). FT TRANSMEM 321 341 7 (Potential). FT DOMAIN 342 357 Cytoplasmic (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT DISULFID 120 192 By similarity. SQ SEQUENCE 357 AA; 40255 MW; 92F8A78C69169790 CRC64; MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH // ID TAR3_RAT STANDARD; PRT; 338 AA. AC Q923Y6; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Trace amine receptor 3 (TaR-3). GN TRAR3 OR TAR3 OR TA3. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=21374364; PubMed=11459929; DOI=10.1073/pnas.151105198; RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., RA Branchek T.A., Gerald C.; RT "Trace amines: identification of a family of mammalian G protein- RT coupled receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001). CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Trace amines are biogenic amines present in very low levels in CC mammalian tissues. Although some trace amines have clearly defined CC roles as neurotransmitters in invertebrates, the extent to which CC they function as true neurotransmitters in vertebrates has CC remained speculative. Trace amines are likely to be involved in a CC variety of physiological functions that have yet to be fully CC understood. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF380190; AAK71241.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01831; TRACEAMINE1R. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 44 1 (Potential). FT DOMAIN 45 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT DOMAIN 80 97 Extracellular (Potential). FT TRANSMEM 98 118 3 (Potential). FT DOMAIN 119 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 4 (Potential). FT DOMAIN 159 187 Extracellular (Potential). FT TRANSMEM 188 208 5 (Potential). FT DOMAIN 209 249 Cytoplasmic (Potential). FT TRANSMEM 250 270 6 (Potential). FT DOMAIN 271 284 Extracellular (Potential). FT TRANSMEM 285 305 7 (Potential). FT DOMAIN 306 338 Cytoplasmic (Potential). FT DISULFID 95 180 By similarity. FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 338 AA; 37846 MW; F8BC058A21664EA4 CRC64; MELCYENVNG SCIKSSYSPW PRAILYAVLG LGALLAVFGN LLVITAILHF KQLHTPTNFL VASLACADFL VGVTVMPFST VRSVEGCWYF GDTYCKFHTC FDTSFCFASL FHLCCISIDR YVAVTDPLTY PTKFTISVSG VCIALSWFFS VTYSFSIFYT GANEEGIEEL VVALTCVGGC QAPLNQNWVL LCFLLFFLPT VVMVFLYGRI FLVAKQQARK IEGSANQPQA SSESYKERVA RRERKAAKTL GIAMAAFLVS WLPYIIDAVI DAYMNFITPA YVYEILVWCV YYNSAMNPLI YAFFYPWFRK AIKLIVSGKV FRADSSRTNL FSEEAGAG // ID TAR6_RAT STANDARD; PRT; 358 AA. AC Q923Y4; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Trace amine receptor 6 (TaR-6). GN TRAR6 OR TAR6 OR TA6. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=21374364; PubMed=11459929; DOI=10.1073/pnas.151105198; RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., RA Branchek T.A., Gerald C.; RT "Trace amines: identification of a family of mammalian G protein- RT coupled receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001). CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Trace amines are biogenic amines present in very low levels in CC mammalian tissues. Although some trace amines have clearly defined CC roles as neurotransmitters in invertebrates, the extent to which CC they function as true neurotransmitters in vertebrates has CC remained speculative. Trace amines are likely to be involved in a CC variety of physiological functions that have yet to be fully CC understood. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF380194; AAK71245.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 47 Extracellular (Potential). FT TRANSMEM 48 68 1 (Potential). FT DOMAIN 69 83 Cytoplasmic (Potential). FT TRANSMEM 84 104 2 (Potential). FT DOMAIN 105 125 Extracellular (Potential). FT TRANSMEM 126 143 3 (Potential). FT DOMAIN 144 166 Cytoplasmic (Potential). FT TRANSMEM 167 187 4 (Potential). FT DOMAIN 188 217 Extracellular (Potential). FT TRANSMEM 218 238 5 (Potential). FT DOMAIN 239 274 Cytoplasmic (Potential). FT TRANSMEM 275 295 6 (Potential). FT DOMAIN 296 309 Extracellular (Potential). FT TRANSMEM 310 333 7 (Potential). FT DOMAIN 334 358 Cytoplasmic (Potential). FT DISULFID 120 205 By similarity. FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential). FT CARBOHYD 210 210 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 358 AA; 40074 MW; CAE028CF89943DCE CRC64; MATDDESFPW DQDSILSRDL LSALSPQLCY ENLNRSCVRS PYSPGPRLIL YAVFGFGAVL AVCGNLLVMT SILHFRQLHS PANFLVASLA CADLLVGLTV MPFSMVRSVE GCWYFGDSYC KLHTSFDMSF CCSSLLHLCF ISVDRYIAVS DPLIYPIRFT ASVSGKCITF SWFLSIIYGF SLIYTGASEA GLKDLVSALS CVGGCQIPMN QSCVLINFLL FLVPTLVMMT VYSKIFLIAK QQAQNMEKMS KQTTRASDSY KDRVAKRERK AAKTLGIAVA AFLLSWLPYL IDSIIDAFLG FITPSYVYEI LVWIVYYNSA MNPLIYAFFY PWFRNAIKLI VTGKILKQNS STTNLFSE // ID TA10_RAT STANDARD; PRT; 344 AA. AC Q923Y0; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Trace amine receptor 10 (TaR-10). GN TRAR10 OR TAR10 OR TA10. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=21374364; PubMed=11459929; DOI=10.1073/pnas.151105198; RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., RA Branchek T.A., Gerald C.; RT "Trace amines: identification of a family of mammalian G protein- RT coupled receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001). CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Trace amines are biogenic amines present in very low levels in CC mammalian tissues. Although some trace amines have clearly defined CC roles as neurotransmitters in invertebrates, the extent to which CC they function as true neurotransmitters in vertebrates has CC remained speculative. Trace amines are likely to be involved in a CC variety of physiological functions that have yet to be fully CC understood. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF380198; AAK71249.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 57 1 (Potential). FT DOMAIN 58 67 Cytoplasmic (Potential). FT TRANSMEM 68 88 2 (Potential). FT DOMAIN 89 102 Extracellular (Potential). FT TRANSMEM 103 127 3 (Potential). FT DOMAIN 128 146 Cytoplasmic (Potential). FT TRANSMEM 147 167 4 (Potential). FT DOMAIN 168 196 Extracellular (Potential). FT TRANSMEM 197 217 5 (Potential). FT DOMAIN 218 260 Cytoplasmic (Potential). FT TRANSMEM 261 281 6 (Potential). FT DOMAIN 282 295 Extracellular (Potential). FT TRANSMEM 296 319 7 (Potential). FT DOMAIN 320 344 Cytoplasmic (Potential). FT DISULFID 96 189 By similarity. FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 344 AA; 38015 MW; 6AB7A52CE3BEB692 CRC64; MTSNFSQATL QLCYENVNAS CIKTPYSPGL RVLLYMVFGF GAVLAVCGNL LVVISVLHFK QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG DTFCSLHSCC DVAFCYSSAL HLCFISVDRY IAVTDPLVYP TKFTVSVSGI CISISWILPL VYSSAVFYTG ISAMGIENLV SALNCVGGCQ VVVNQDWVLI SFLLFFIPTL VMIILYSKIF LVAKQQAVKI ETSVSGSKGE SSLESHKARV AKRERKAAKT LGVTVLAFIV SWLPYTIDTL IDAFMGFITP AYVYEFCCWS AYYNSAMNPL IYAFFYPWFR KAMKLILSGK ILKGHSSTTS LFSE // ID CKR5_GORGO STANDARD; PRT; 352 AA. AC P56439; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5). GN CCR5 OR CMKBR5. OS Gorilla gorilla gorilla (Lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97268687; PubMed=9108095; RA Edinger A.L., Amedee A., Miller K., Doranz B.J., Endres M., RA Sharron M., Samson M., Lu Z.H., Clements J.E., Murphey-Corb M., RA Peiper S.C., Parmentier M., Broder C.C., Doms R.W.; RT "Differential utilization of CCR5 by macrophage and T cell tropic RT simian immunodeficiency virus strains."; RL Proc. Natl. Acad. Sci. U.S.A. 94:4005-4010(1997). CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, CC MIP-1-beta and RANTES and subsequently transduces a signal by CC increasing the intracellular calcium ions level. May play a role CC in the control of granulocytic lineage proliferation or CC differentiation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF005659; AAB62553.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Sulfation. FT DOMAIN 1 30 Extracellular (Potential). FT TRANSMEM 31 58 1 (Potential). FT DOMAIN 59 68 Cytoplasmic (Potential). FT TRANSMEM 69 89 2 (Potential). FT DOMAIN 90 102 Extracellular (Potential). FT TRANSMEM 103 124 3 (Potential). FT DOMAIN 125 141 Cytoplasmic (Potential). FT TRANSMEM 142 166 4 (Potential). FT DOMAIN 167 198 Extracellular (Potential). FT TRANSMEM 199 218 5 (Potential). FT DOMAIN 219 235 Cytoplasmic (Potential). FT TRANSMEM 236 260 6 (Potential). FT DOMAIN 261 277 Extracellular (Potential). FT TRANSMEM 278 301 7 (Potential). FT DOMAIN 302 352 Cytoplasmic (Potential). FT DISULFID 101 178 By similarity. FT MOD_RES 3 3 Sulfotyrosine (By similarity). FT MOD_RES 10 10 Sulfotyrosine (By similarity). FT MOD_RES 14 14 Sulfotyrosine (By similarity). FT MOD_RES 15 15 Sulfotyrosine (By similarity). SQ SEQUENCE 352 AA; 40515 MW; D0E6FCB9FE5EAC84 CRC64; MDYQVSSPTY DIDYYTSEPC QKTNVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII LLTIDRYLAI VHAVFALKAR TVTFGVVTSV ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL // ID AG2R_SHEEP STANDARD; PRT; 359 AA. AC O77590; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Type-1 angiotensin II receptor (AT1). GN AGTR1. OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99103586; PubMed=9888511; RA Millican D.S., Bird I.M.; RT "Isolation of an ovine genomic sequence containing the full-length RT angiotensin II type-1 receptor."; RL Endocr. Res. 24:387-390(1998). RN [2] RP SEQUENCE OF 1-132 FROM N.A. RC TISSUE=Adrenal cortex; RX MEDLINE=98351904; PubMed=9687288; RA Bird I.M., Millican D.S., Magness R.R.; RT "Specific pregnancy-induced angiotensin II type-1 receptor expression RT in ovine uterine artery does not involve formation of alternate splice RT variants or alternate promoter usage."; RL Biol. Reprod. 59:219-224(1998). CC -!- FUNCTION: Receptor for angiotensin II. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF069750; AAC99344.1; -. DR EMBL; AF056308; AAC32613.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 27 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 28 52 1 (POTENTIAL). FT DOMAIN 53 64 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 65 87 2 (POTENTIAL). FT DOMAIN 88 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 124 3 (POTENTIAL). FT DOMAIN 125 142 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 143 162 4 (POTENTIAL). FT DOMAIN 163 192 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 193 214 5 (POTENTIAL). FT DOMAIN 215 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 262 6 (POTENTIAL). FT DOMAIN 263 275 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 276 296 7 (POTENTIAL). FT DOMAIN 297 359 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 176 176 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 188 188 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 101 180 BY SIMILARITY. FT LIPID 355 355 S-palmitoyl cysteine (Potential). SQ SEQUENCE 359 AA; 41046 MW; C07010F1A4110CF7 CRC64; MILNSSTEDG IKRIQDDCPK AGRHNYIFIM IPTLYSIIFV VGLFGNSLVV IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASGSVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPTIIHRNVF FIENTNITVC AFHYESQNST LPVGLGLTKN ILGFLFPFLI ILTSYTLIWK TLKKAYEIQK NKPRKDDIFK IILAIVLFFF FSWVPHQIFT FMDVLIQLGL IRDCKIEDIV DTAMPITICL AYFNNCLNPP FYGFLGKKFK KYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSENGNSSTK KPAPCTEVE // ID AG2S_HUMAN STANDARD; PRT; 359 AA. AC Q13725; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Type-1B angiotensin II receptor (AT1B) (AT1BR). GN AGTR1B OR AT2R1B. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RX MEDLINE=94183213; PubMed=8135787; RA Konishi H., Kuroda S., Inada Y., Fujisawa Y.; RT "Novel subtype of human angiotensin II type 1 receptor: cDNA cloning RT and expression."; RL Biochem. Biophys. Res. Commun. 199:467-474(1994). CC -!- FUNCTION: Receptor for angiotensin II. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: EXPRESSED IN THE LUNG, PLACENTA AND LIVER. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D13814; BAA02968.1; -. DR PIR; I39418; I39418. DR HSSP; P34996; 1DDD. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004945; F:angiotensin type II receptor activity; NAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 27 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 28 52 1 (POTENTIAL). FT DOMAIN 53 64 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 65 87 2 (POTENTIAL). FT DOMAIN 88 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 124 3 (POTENTIAL). FT DOMAIN 125 142 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 143 162 4 (POTENTIAL). FT DOMAIN 163 192 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 193 214 5 (POTENTIAL). FT DOMAIN 215 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 262 6 (POTENTIAL). FT DOMAIN 263 275 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 276 296 7 (POTENTIAL). FT DOMAIN 297 359 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 176 176 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 188 188 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 101 180 BY SIMILARITY. FT LIPID 355 355 S-palmitoyl cysteine (Potential). SQ SEQUENCE 359 AA; 41020 MW; 298DFD3FF50D4EA4 CRC64; MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESRNST LPIGLGLTKN ILGSCFPFLI ILTSYTLIWK ALKKAYEIQK NNPRNDDIFR IIMAIVLFFF FSWIPHQIFT FLDVLIQQGI IRDCRIADIV DTAMPITIWI AYFNNCLNPL FYGFLGKKFK KDILQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE // ID IL8B_MACMU STANDARD; PRT; 353 AA. AC Q28519; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE High affinity interleukin-8 receptor B (IL-8R B) (CXCR-2) (Fragment). GN IL8RB OR CXCR2. OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=96175151; PubMed=9110929; RA Alvarez V., Coto E., Setien F., Gonzalez S., Gonzalez-Roces S., RA Lopez-Larrea C.; RT "Characterization of interleukin-8 receptors in non-human primates."; RL Immunogenetics 43:261-267(1996). CC -!- FUNCTION: RECEPTOR TO INTERLEUKIN-8, WHICH IS A POWERFUL CC NEUTROPHILS CHEMOTACTIC FACTOR. BINDING OF IL-8 TO THE RECEPTOR CC CAUSES ACTIVATION OF NEUTROPHILS. THIS RESPONSE IS MEDIATED VIA A CC G-PROTEIN THAT ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND CC MESSENGER SYSTEM. THIS RECEPTOR BINDS TO IL-8 WITH A HIGH AFFINITY CC AND TO GRO/MGSA AND NAP-2 ALSO WITH A HIGH AFFINITY. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X91116; CAA62565.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Chemotaxis. FT NON_TER 1 1 FT DOMAIN <1 45 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 46 72 1 (POTENTIAL). FT DOMAIN 73 81 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 82 102 2 (POTENTIAL). FT DOMAIN 103 117 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 118 139 3 (POTENTIAL). FT DOMAIN 140 160 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 161 180 4 (POTENTIAL). FT DOMAIN 181 205 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 206 228 5 (POTENTIAL). FT DOMAIN 229 248 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 249 270 6 (POTENTIAL). FT DOMAIN 271 291 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 292 312 7 (POTENTIAL). FT DOMAIN 313 >353 CYTOPLASMIC (POTENTIAL). FT DISULFID 116 193 BY SIMILARITY. FT CARBOHYD 19 19 N-LINKED (GLCNAC...) (POTENTIAL). FT NON_TER 353 353 SQ SEQUENCE 353 AA; 39947 MW; EC8B38130657C713 CRC64; FNMESDSFED LWKGEDFSNY SYSSDLPPSL PDVAPCRPES LEINKYFVVI IYALVFLLSL LGNSLVMLVI LYSRVGRSVT DVYLLNLALA DLLFALTLPI WAASKVNGWI FGTFLCKVVS LLKEVNFYSG ILLLACISVD RYLAIVHATR TLTQKRYLVK FICLSIWGLS LLLALPVLLF RRTVYSSNVS PACYEDMGNN TANWRMLLRI LPQSFGFIVP LLIMLFCYGF TLRTLFKAHM GQKHRAMRVI FAVVLIFLLC WLPYSLVLLA DTLMRTQVIQ ETCERRNHID RALDATEILG ILHSCLNPLI YAFIGQKFRH GLLKILAIHG LISKDSLPKD SRPSFVGSSS GHT // ID CKR9_HUMAN STANDARD; PRT; 357 AA. AC P51686; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (GPR-9- DE 6). GN CCR9 OR CMKBR9. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Lautens L.L., Tiffany H.L., Gao J.-L., Modi W., Murphy P.M., RA Bonner T.I.; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RA Warren C.N., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP CHARACTERIZATION. RX MEDLINE=99248139; PubMed=10229797; RA Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.; RT "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the RT receptor for the chemokine TECK."; RL J. Immunol. 162:5671-5675(1999). CC -!- FUNCTION: Receptor for chemokine SCYA25/TECK. Subsequently CC transduces a signal by increasing the intracellular calcium ions CC level. Alternative coreceptor with CD4 for HIV-1 infection. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Highly expressed in the thymus and low in CC lymph nodes and spleen. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U45982; AAA93319.1; -. DR EMBL; AY242127; AAO92294.1; -. DR Genew; HGNC:1610; CCR9. DR MIM; 604738; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0006968; P:cellular defense response; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR004069; CC_9_receptor. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01531; CHEMOKINER9. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 64 1 (Potential). FT DOMAIN 65 73 Cytoplasmic (Potential). FT TRANSMEM 74 94 2 (Potential). FT DOMAIN 95 108 Extracellular (Potential). FT TRANSMEM 109 130 3 (Potential). FT DOMAIN 131 148 Cytoplasmic (Potential). FT TRANSMEM 149 169 4 (Potential). FT DOMAIN 170 198 Extracellular (Potential). FT TRANSMEM 199 226 5 (Potential). FT DOMAIN 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 268 6 (Potential). FT DOMAIN 269 292 Extracellular (Potential). FT TRANSMEM 293 310 7 (Potential). FT DOMAIN 311 357 Cytoplasmic (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT DISULFID 107 186 By similarity. SQ SEQUENCE 357 AA; 40713 MW; 96982E0B922F6B31 CRC64; MADDYGSEST SSMEDYVNFN FTDFYCEKNN VRQFASHFLP PLYWLVFIVG ALGNSLVILV YWYCTRVKTM TDMFLLNLAI ADLLFLVTLP FWAIAAADQW KFQTFMCKVV NSMYKMNFYS CVLLIMCISV DRYIAIAQAM RAHTWREKRL LYSKMVCFTI WVLAAALCIP EILYSQIKEE SGIAICTMVY PSDESTKLKS AVLTLKVILG FFLPFVVMAC CYTIIIHTLI QAKKSSKHKA LKVTITVLTV FVLSQFPYNC ILLVQTIDAY AMFISNCAVS TNIDICFQVT QTIAFFHSCL NPVLYVFVGE RFRRDLVKTL KNLGCISQAQ WVSFTRREGS LKLSSMLLET TSGALSL // ID AG2R_XENLA STANDARD; PRT; 362 AA. AC P32303; Q91383; DT 01-OCT-1993 (Rel. 27, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Type-1-like angiotensin II receptor 1 (AT1). OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus. OX NCBI_TaxID=8355; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Heart; RX MEDLINE=93343933; PubMed=7688227; RA Ji H., Sandberg K., Zhang Y., Catt K.J.; RT "Molecular cloning, sequencing and functional expression of an RT amphibian angiotensin II receptor."; RL Biochem. Biophys. Res. Commun. 194:756-762(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Heart; RX MEDLINE=94325348; PubMed=7519446; RA Nishimatsu S., Koyasu N., Sugaya T., Ohnishi J., Yamagishi T., RA Murakami K., Miyazaki H.; RT "Isolation and characterization of two alternatively spliced RT complementary DNAs encoding a Xenopus laevis angiotensin II RT receptor."; RL Biochim. Biophys. Acta 1218:401-407(1994). CC -!- FUNCTION: Receptor for angiotensin II. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L16463; AAA49647.1; -. DR EMBL; S73388; AAD14966.2; -. DR EMBL; S73274; AAC60749.1; -. DR PIR; JN0694; JN0694. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 53 1 (POTENTIAL). FT DOMAIN 54 65 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 66 88 2 (POTENTIAL). FT DOMAIN 89 103 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 104 125 3 (POTENTIAL). FT DOMAIN 126 143 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 144 163 4 (POTENTIAL). FT DOMAIN 164 193 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 194 215 5 (POTENTIAL). FT DOMAIN 216 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 261 6 (POTENTIAL). FT DOMAIN 262 274 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 275 295 7 (POTENTIAL). FT DOMAIN 296 362 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 3 3 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 177 177 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 102 181 BY SIMILARITY. FT LIPID 361 361 S-palmitoyl cysteine (Potential). SQ SEQUENCE 362 AA; 41293 MW; 7E0CA09B185E7D57 CRC64; MSNASTVETS DVERIAVNCS KSGMHNYIFI AIPIIYSTIF VVGVFGNSMV VIVIYSYMKM KTVASIFLMN LALSDLCFVI TLPLWAAYTA MHYHWPFGNF LCKVASTAIT LNLYTTVFLL TCLSIDRYSA IVHPMKSRIW RTAMVARLTC VGIWLVAFLA SMPSIIYRQI YLFHDTNQTV CAIVYDSGHI YFMVGMSLAK NIVGFLIPFL IILTSYTLIG KTLKEVYRAQ RARNDDIFKM IVAVVLLFFF CWIPYQVFTF LDVLIQMDVI QNCKMYDIVD TGMPITICIA YFNSCLNPFL YGFFGKNFRK HFLQLIKYIP PKMRTHASVN TKSSLVSSSL SDTKRASKKI ALQMTDNEEH CK // ID CCR4_CERTO STANDARD; PRT; 352 AA. AC O62747; DT 15-DEC-1998 (Rel. 37, Created) DT 15-DEC-1998 (Rel. 37, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (SDF-1 receptor) DE (Stromal cell-derived factor 1 receptor) (Fusin) (LESTR). GN CXCR4. OS Cercocebus torquatus atys (Red-crowned mangabey) (Sooty mangabey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Cercocebus. OX NCBI_TaxID=9531; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98321155; PubMed=9656999; RA Chen Z., Gettie A., Ho D.D., Marx P.A.; RT "Primary SIVsm isolates use the CCR5 coreceptor from sooty mangabeys RT naturally infected in west Africa: a comparison of coreceptor usage RT of primary SIVsm, HIV-2, and SIVmac."; RL Virology 246:113-124(1998). CC -!- FUNCTION: Receptor for the C-X-C chemokine SDF-1. Transduces a CC signal by increasing the intracellular calcium ions level. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Sulfated (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF051906; AAC39834.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Sulfation. FT DOMAIN 1 39 Extracellular (Potential). FT TRANSMEM 40 63 1 (Potential). FT DOMAIN 64 79 Cytoplasmic (Potential). FT TRANSMEM 80 99 2 (Potential). FT DOMAIN 100 110 Extracellular (Potential). FT TRANSMEM 111 132 3 (Potential). FT DOMAIN 133 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 4 (Potential). FT DOMAIN 176 200 Extracellular (Potential). FT TRANSMEM 201 220 5 (Potential). FT DOMAIN 221 240 Cytoplasmic (Potential). FT TRANSMEM 241 261 6 (Potential). FT DOMAIN 262 285 Extracellular (Potential). FT TRANSMEM 286 305 7 (Potential). FT DOMAIN 306 352 Cytoplasmic (Potential). FT MOD_RES 21 21 Sulfotyrosine (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT DISULFID 109 186 By similarity. SQ SEQUENCE 352 AA; 39648 MW; 4027432B8032F87E CRC64; MEGISIYTSD NYTEEMGSGD YDSIKEPCFR EKNAHFNRIF LPTIYSIIFL TGIVGNGLVI LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL YSSVLILAFI SLDRYLAIVH ATNSQKPRKL LAEKVVYVGV WIPALLLTIP GFIFASVSEA DDRFICDRFY PNDLWVVVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS // ID CKR6_MOUSE STANDARD; PRT; 367 AA. AC O54689; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (KY411). GN CCR6 OR CMKBR6. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RA Yanagihara S., Komura E., Yamaguchi Y.; RT "Mouse G protein-coupled receptor KY411."; RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=99077268; PubMed=9862452; RA Varona R., Zaballos A., Gutierrez J., Martin P., Roncal F., RA Albar J.P., Ardavin C., Marquez G.; RT "Molecular cloning, functional characterization and mRNA expression RT analysis of the murine chemokine receptor CCR6 and its specific ligand RT MIP-3alpha."; RL FEBS Lett. 440:188-194(1998). CC -!- FUNCTION: RECEPTOR FOR A C-C TYPE CHEMOKINE. BINDS TO MIP-3- CC ALPHA/LARC AND SUBSEQUENTLY TRANSDUCES A SIGNAL BY INCREASING THE CC INTRACELLULAR CALCIUM IONS LEVEL. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB009369; BAA23776.1; -. DR EMBL; AJ222714; CAA10956.1; -. DR MGD; MGI:1333797; Ccr6. DR InterPro; IPR004067; CC_chemkine6. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01529; CHEMOKINER6. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 39 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 40 66 1 (POTENTIAL). FT DOMAIN 67 75 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 76 96 2 (POTENTIAL). FT DOMAIN 97 111 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 112 133 3 (POTENTIAL). FT DOMAIN 134 151 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 152 172 4 (POTENTIAL). FT DOMAIN 173 203 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 204 230 5 (POTENTIAL). FT DOMAIN 231 246 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 247 271 6 (POTENTIAL). FT DOMAIN 272 295 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 296 313 7 (POTENTIAL). FT DOMAIN 314 367 CYTOPLASMIC (POTENTIAL). FT DISULFID 110 189 BY SIMILARITY. FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 35 35 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 367 AA; 42102 MW; 6A309AF833B1117E CRC64; MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV FGLLGNIMVV MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT NTWVFSDALC KLMKGTYAVN FNCGMLLLAC ISMDRYIAIV QATKSFRVRS RTLTHSKVIC VAVWFISIII SSPTFIFNKK YELQDRDVCE PRYRSVSEPI TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK RHRAIRVVIA VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS RQTSETVEND NASSFTM // ID OPRD_RAT STANDARD; PRT; 372 AA. AC P33533; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Delta-type opioid receptor (DOR-1) (Opioid receptor A). GN OPRD1 OR ROR-A. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=93351652; PubMed=8394245; RA Fukuda K., Kato S., Mori K., Nishi M., Takeshima H.; RT "Primary structures and expression from cDNAs of rat opioid receptor RT delta- and mu-subtypes."; RL FEBS Lett. 327:311-314(1993). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RX MEDLINE=94322412; PubMed=7519274; RA Abood M.E., Noel M.A., Farnsworth J.S., Tao Q.; RT "Molecular cloning and expression of a delta-opioid receptor from rat RT brain."; RL J. Neurosci. Res. 37:714-719(1994). CC -!- FUNCTION: Inhibits neurotransmitter release by reducing calcium CC ion currents and increasing potassium ion conductance. Highly CC stereoselective. receptor for enkephalins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D16348; BAA03851.1; -. DR EMBL; U00475; AAA19939.1; -. DR PIR; S34592; S34592. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 45 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 46 75 1 (POTENTIAL). FT DOMAIN 76 84 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 85 102 2 (POTENTIAL). FT DOMAIN 103 124 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 125 144 3 (POTENTIAL). FT DOMAIN 145 174 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 175 190 4 (POTENTIAL). FT DOMAIN 191 215 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 216 238 5 (POTENTIAL). FT DOMAIN 239 261 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 262 284 6 (POTENTIAL). FT DOMAIN 285 293 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 294 310 7 (POTENTIAL). FT DOMAIN 311 372 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 33 33 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 121 198 BY SIMILARITY. FT LIPID 333 333 S-palmitoyl cysteine (Potential). SQ SEQUENCE 372 AA; 40449 MW; F578BD1F64C61D50 CRC64; MEPVPSARAE LQFSLLANVS DTFPSAFPSA SANASGSPGA RSASSLALAI AITALYSAVC AVGLLGNVLV MFGIVRYTKL KTATNIYIFN LALADALATS TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTQ PRDGAVVCTL QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDIN RRDPLVVAAL HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRAPCGGQ EPGSLRRPRQ ATARERVTAC TPSDGPGGGA AA // ID SSR4_HUMAN STANDARD; PRT; 388 AA. AC P31391; Q9UIY1; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Somatostatin receptor type 4 (SS4R). GN SSTR4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93290656; PubMed=8512564; RA Xu Y., Song J., Bruno J.F., Berelowitz M.; RT "Molecular cloning and sequencing of a human somatostatin receptor, RT hSSTR4."; RL Biochem. Biophys. Res. Commun. 193:648-652(1993). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=93248256; PubMed=8483934; RA Rohrer L., Raulf F., Bruns C., Buettner R., Hofstaedter F., RA Schuele R.; RT "Cloning and characterization of a fourth human somatostatin RT receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 90:4196-4200(1993). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=93384611; PubMed=8373420; RA Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., RA Ihara Y., Li Q., Imura H., Seino S., Seino Y.; RT "Cloning, functional expression and pharmacological characterization RT of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor RT subtype."; RL Biochem. Biophys. Res. Commun. 195:844-852(1993). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=93302729; PubMed=8100352; RA Demchyshyn L.L., Srikant C.B., Sunahara R.K., Kent G., Seeman P., RA van Tol H.H.M., Panetta R., Patel Y.C., Niznik H.B.; RT "Cloning and expression of a human somatostatin-14-selective receptor RT variant (somatostatin receptor 4) located on chromosome 20."; RL Mol. Pharmacol. 43:894-901(1993). RN [5] RP SEQUENCE FROM N.A. RX MEDLINE=21638749; PubMed=11780052; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). CC -!- FUNCTION: Receptor for somatostatin-14. The activity of this CC receptor is mediated by G proteins which inhibits adenylyl CC cyclase. It is functionally coupled not only to inhibition of CC adenylate cyclase, but also to activation of both arachidonate CC release and mitogen-activated protein (MAP) kinase cascade. CC Mediates antiproliferative action of somatostatin in tumor cells. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Specifically expressed in fetal and adult CC brain, lung tissue, stomach, and in lesser quantities in the CC kidney, pituitary and adrenals. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D16826; BAA04106.1; -. DR EMBL; L14856; AAA36623.1; -. DR EMBL; L07833; AAA60565.1; -. DR EMBL; L07061; -; NOT_ANNOTATED_CDS. DR EMBL; AL049651; CAB51953.1; -. DR PIR; JN0605; JN0605. DR HSSP; P02699; 1BOJ. DR Genew; HGNC:11333; SSTR4. DR MIM; 182454; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004994; F:somatostatin receptor activity; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0008285; P:negative regulation of cell proliferation; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00590; SOMATOSTTN4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate; Phosphorylation; KW Polymorphism. FT DOMAIN 1 46 Extracellular (Potential). FT TRANSMEM 47 73 1 (Potential). FT DOMAIN 74 83 Cytoplasmic (Potential). FT TRANSMEM 84 104 2 (Potential). FT DOMAIN 105 120 Extracellular (Potential). FT TRANSMEM 121 142 3 (Potential). FT DOMAIN 143 161 Cytoplasmic (Potential). FT TRANSMEM 162 185 4 (Potential). FT DOMAIN 186 208 Extracellular (Potential). FT TRANSMEM 209 232 5 (Potential). FT DOMAIN 233 260 Cytoplasmic (Potential). FT TRANSMEM 261 280 6 (Potential). FT DOMAIN 281 291 Extracellular (Potential). FT TRANSMEM 292 314 7 (Potential). FT DOMAIN 315 388 Cytoplasmic (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT DISULFID 119 198 By similarity. FT LIPID 327 327 S-palmitoyl cysteine (Potential). FT VARIANT 83 83 N -> T (in dbSNP:1065191). FT /FTId=VAR_011703. FT CONFLICT 284 284 V -> F (in Ref. 4 and 5). FT CONFLICT 321 321 S -> F (in Ref. 5). FT CONFLICT 365 365 P -> K (in Ref. 2). SQ SEQUENCE 388 AA; 41894 MW; 8BCCD69B5F3BC2F5 CRC64; MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI QCIYALVCLV GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV PFVASSAALR HWPFGSVLCR AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH PLRAATYRRP SVAKLINLGV WLASLLVTLP IAIFADTRPA RGGQAVACNL QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA VALRAGWQQR RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLVVTSLDA TVNHVSLILS YANSCANPIL YGFLSDNFRR SFQRVLCLRC CLLEGAGGAE EEPLDYYATA LKSKGGAGCM CPPLPCQQEA LQPEPGRKRI PLTRTTTF // ID SSR2_BOVIN STANDARD; PRT; 368 AA. AC P34993; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Somatostatin receptor type 2 (SS2R) (SRIF-1). GN SSTR2. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Xin W.W., Wong M.-L., Rimland J., Nestler E.J., Duman R.S.; RT "Characterization and functional expression of a somatostatin receptor RT isolated from locus Coeruleus."; RL Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for somatostatins-14 and -28. This receptor is CC coupled via pertussis toxin sensitive G proteins to inhibition of CC adenylyl cyclase. In addition it stimulates phosphotyrosine CC phosphatase and PLC via pertussis toxin insensitive as well as CC sensitive G proteins. In RIN-5F cells, this receptor inhibits CC calcium entry by suppressing voltage dependent calcium-channels. CC -!- SUBUNIT: The C-terminus interacts with SHANK1 PDZ domain (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L06613; AAA30764.1; -. DR HSSP; P02699; 1BOJ. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00588; SOMATOSTTN2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 42 Extracellular (Potential). FT TRANSMEM 43 66 1 (Potential). FT DOMAIN 67 77 Cytoplasmic (Potential). FT TRANSMEM 78 102 2 (Potential). FT DOMAIN 103 117 Extracellular (Potential). FT TRANSMEM 118 137 3 (Potential). FT DOMAIN 138 160 Cytoplasmic (Potential). FT TRANSMEM 161 180 4 (Potential). FT DOMAIN 181 206 Extracellular (Potential). FT TRANSMEM 207 228 5 (Potential). FT DOMAIN 229 252 Cytoplasmic (Potential). FT TRANSMEM 253 277 6 (Potential). FT DOMAIN 278 287 Extracellular (Potential). FT TRANSMEM 288 302 7 (Potential). FT DOMAIN 303 368 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT DISULFID 114 192 By similarity. FT LIPID 327 327 S-palmitoyl cysteine (Potential). SQ SEQUENCE 368 AA; 41133 MW; B5852262A6BB080B CRC64; MDLVSELNET QPWLTTPFDL NGSVGAANIS NQTEPYYDLA SNVVLTFIYF VVCIIGLCGN TLVIYVILRY AKMKTITNIY ILNLAIADEL FMLGLPFLAM QVALVHWPFG KAICRVVMTV DGINQFTSIF CLTVMSIDRY LAVVHPIKSA KWRRPRTAKM INVAVWGVSL LVILPIMIYA GLRSNQWGRS SCTINWPGES GAWYTGFIIY AFILGFLVPL TIICLCYLFI IIKVKSSGIR VGSSKRKKSE KKVTRMVSIV VAVFIFCWLP FYIFNVSSVS VAISPTPALK GMFDFVVVLT YANSCANPIL YAFLSDNFKK SFQNVLCLVK VSGTDDGERS DSKQDKSRLN ETTETQRTLL NGDLQTSI // ID SSR4_MOUSE STANDARD; PRT; 384 AA. AC P49660; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Somatostatin receptor type 4 (SS4R). GN SSTR4 OR SMSTR4. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=129/SvJ; TISSUE=Liver; RX MEDLINE=96194903; PubMed=8654950; RA Schwabe W., Brennan M.B., Hochgeschwender U.; RT "Isolation and characterization of the mouse (Mus musculus) RT somatostatin receptor type-4-encoding gene (mSSTR4)."; RL Gene 168:233-235(1996). CC -!- FUNCTION: RECEPTOR FOR SOMATOSTATIN-14. THE ACTIVITY OF THIS CC RECEPTOR IS MEDIATED BY G PROTEINS WHICH INHIBITS ADENYLYL CC CYCLASE. IT IS FUNCTIONALLY COUPLED NOT ONLY TO INHIBITION OF CC ADENYLATE CYCLASE, BUT ALSO TO ACTIVATION OF BOTH ARACHIDONATE CC RELEASE AND MITOGEN-ACTIVATED PROTEIN (MAP) KINASE CASCADE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U26176; AAA67561.1; -. DR PIR; JC4629; JC4629. DR HSSP; P02699; 1BOJ. DR MGD; MGI:105372; Sstr4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 41 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 42 69 1 (POTENTIAL). FT DOMAIN 70 79 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 80 105 2 (POTENTIAL). FT DOMAIN 106 116 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 117 138 3 (POTENTIAL). FT DOMAIN 139 160 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 161 181 4 (POTENTIAL). FT DOMAIN 182 203 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 204 228 5 (POTENTIAL). FT DOMAIN 229 254 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 255 280 6 (POTENTIAL). FT DOMAIN 281 287 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 288 311 7 (POTENTIAL). FT DOMAIN 312 384 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 21 21 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 115 194 BY SIMILARITY. FT LIPID 323 323 S-palmitoyl cysteine (Potential). SQ SEQUENCE 384 AA; 42089 MW; 04DB0751481C6BFB CRC64; MNAPATLLRG VEDTTWTPGI NASWAPEQEE DAMGSDGTGT AGMVTIQCIY ALVCLVGLVG NALVIFVILR YAKMKTATNI YLLNLAVADE LFMLSVPFVR SAAALRHWPF GAVLCRAVLS VDGLNMFTSV FCLTVLSVDR YVAVVHPLRT ATYRRPSVAK LINLGVWLAS LLVTLPIAVF ADTRPARGGE AVACNLHWPH PAWSAVFVIY TFLLGFLPPV LAIGLCYLLI VGKMRAVALR GGWQQRRRSE KKITRLVLMV VTVFVLCWMP FYVVQLLNLF VTSLDATVNH VSLILSYANS CANPILYGFL SDNFRRSFQR VLCLRCCLLE TTGGAEEEPL DYYATALKSR GGAGCICPPL PCQQEPVQAE PGCKQVPFTK TTTF // ID APJ_MACMU STANDARD; PRT; 380 AA. AC O97666; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Apelin receptor (G protein-coupled receptor APJ) (Angiotensin DE receptor-like 1). GN AGTRL1 OR APJ. OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Spleen; RX MEDLINE=21354176; PubMed=11461684; RA Margulies B.J., Hauer D.A., Clements J.E.; RT "Identification and comparison of eleven rhesus macaque chemokine RT receptors."; RL AIDS Res. Hum. Retroviruses 17:981-986(2001). CC -!- FUNCTION: Receptor for apelin coupled to G proteins that inhibit CC adenylate cyclase activity. Alternative coreceptor with CD4 for CC SIV infection. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF100206; AAC72404.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 26 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 27 51 1 (POTENTIAL). FT DOMAIN 52 66 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 67 91 2 (POTENTIAL). FT DOMAIN 92 100 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 101 125 3 (POTENTIAL). FT DOMAIN 126 144 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 145 166 4 (POTENTIAL). FT DOMAIN 167 200 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 201 221 5 (POTENTIAL). FT DOMAIN 222 244 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 245 271 6 (POTENTIAL). FT DOMAIN 272 284 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 285 308 7 (POTENTIAL). FT DOMAIN 309 380 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 15 15 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 175 175 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 380 AA; 42606 MW; E84F03E31FABF7ED CRC64; MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF SCKLSSYLIF VNMYASVFCL TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVFRTT GDLENTTKVQ CYMDYSMVAT VSSDWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNV FPYCTCISYV NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK GGEQMHEKSI PYSQETLVVD // ID CCR5_RAT STANDARD; PRT; 374 AA. AC P34997; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt'S lymphoma DE receptor 1 homolog) (Neurolymphatic receptor) (NLR). GN BLR1 OR CXCR5. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Spleen; RX MEDLINE=93238948; PubMed=8386678; RA Kouba M., Vanetti M., Wang X., Schaefer M., Hoellt V.; RT "Cloning of a novel putative G-protein-coupled receptor (NLR) which RT is expressed in neuronal and lymphatic tissue."; RL FEBS Lett. 321:173-178(1993). CC -!- FUNCTION: Cytokine receptor that binds to B lymphocyte CC chemoattractant (BLC) (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in neuronal and lymphatic tissue. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X71463; CAA50582.1; -. DR PIR; S32785; S32785. DR RGD; 62010; Blr1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00564; CXCCHMKINER5. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW B-cell activation; G-protein coupled receptor; Transmembrane; KW Glycoprotein. FT DOMAIN 1 57 Extracellular (Potential). FT TRANSMEM 58 78 1 (Potential). FT DOMAIN 79 90 Cytoplasmic (Potential). FT TRANSMEM 91 111 2 (Potential). FT DOMAIN 112 126 Extracellular (Potential). FT TRANSMEM 127 147 3 (Potential). FT DOMAIN 148 169 Cytoplasmic (Potential). FT TRANSMEM 170 190 4 (Potential). FT DOMAIN 191 221 Extracellular (Potential). FT TRANSMEM 222 242 5 (Potential). FT DOMAIN 243 261 Cytoplasmic (Potential). FT TRANSMEM 262 282 6 (Potential). FT DOMAIN 283 306 Extracellular (Potential). FT TRANSMEM 307 327 7 (Potential). FT DOMAIN 328 374 Cytoplasmic (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT CARBOHYD 198 198 N-linked (GlcNAc...) (Potential). FT DISULFID 124 204 Potential. SQ SEQUENCE 374 AA; 42012 MW; D87A3AC816207319 CRC64; MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS FKTIFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF LFALPELLFA KVVQPHNNES LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY VGVVHRLLQA QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPGWRKS SLSESENATS LTTF // ID APJ_MOUSE STANDARD; PRT; 377 AA. AC Q9WV08; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Apelin receptor (G protein-coupled receptor APJ) (Angiotensin DE receptor-like 1) (MSR). GN AGTRL1 OR APJ. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99400121; PubMed=10473142; RA Devic E., Rizzoti K., Bodin S., Knibiehler B., Audigier Y.; RT "Amino acid sequence and embryonic expression of msr/apj, the mouse RT homolog of Xenopus X-msr and human APJ."; RL Mech. Dev. 84:199-203(1999). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=FVB/N; TISSUE=Mammary gland; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for apelin coupled to G proteins that inhibit CC adenylate cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Detected in the endothelium of the primary CC blood vessels and the forming heart. Might be expressed in a CC subpopulation of endothelial precursors and a mesenchymal CC population derived from paraaxial mesoderm. CC -!- DEVELOPMENTAL STAGE: Detected from embryonic day 8 (E8) and CC throughout the subsequent stages of formation of the CC cardiovascular system. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AJ007612; CAB50696.1; -. DR EMBL; BC039224; AAH39224.1; -. DR MGD; MGI:1346086; Agtrl1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 24 Extracellular (Potential). FT TRANSMEM 25 49 1 (Potential). FT DOMAIN 50 64 Cytoplasmic (Potential). FT TRANSMEM 65 89 2 (Potential). FT DOMAIN 90 98 Extracellular (Potential). FT TRANSMEM 99 123 3 (Potential). FT DOMAIN 124 142 Cytoplasmic (Potential). FT TRANSMEM 143 164 4 (Potential). FT DOMAIN 165 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 242 Cytoplasmic (Potential). FT TRANSMEM 243 269 6 (Potential). FT DOMAIN 270 282 Extracellular (Potential). FT TRANSMEM 283 306 7 (Potential). FT DOMAIN 307 377 Cytoplasmic (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 173 173 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 377 AA; 42266 MW; AA443A7800A24E0B CRC64; MEDDGYNYYG ADNQSECDYA DWKPSGALIP AIYMLVFLLG TTGNGLVLWT VFRTSREKRR SADIFIASLA VADLTFVVTL PLWATYTYRE FDWPFGTFSC KLSSYLIFVN MYASVFCLTG LSFDRYLAIV RPVANARLRL RVSGAVATAV LWVLAALLAV PVMVFRSTDA SENGTKIQCY MDYSMVATSN SEWAWEVGLG VSSTAVGFVV PFTIMLTCYF FIAQTIAGHF RKERIEGLRK RRRLLSIIVV LVVTFALCWM PYHLVKTLYM LGSLLHWPCD FDIFLMNVFP YCTCISYVNS CLNPFLYAFF DPRFRQACTS MLCCDQSGCK GTPHSSSAEK SASYSSGHSQ GPGPNMGKGG EQMHEKSIPY SQETLVD // ID R3R1_MOUSE STANDARD; PRT; 472 AA. AC Q8BGE9; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Relaxin 3 receptor 1 (G-protein coupled receptor SALPR homolog). GN SALPR. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6J; TISSUE=Brain, Cerebellum, and Dorsal root ganglion; RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for relaxin-3. Binding of the ligand inhibit CC cAMP accumulation (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AK043414; BAC31542.1; -. DR EMBL; AK046367; BAC32691.1; -. DR EMBL; AK084001; BAC39091.1; -. DR EMBL; BC053073; AAH53073.1; -. DR MGD; MGI:2441827; Salpr. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 81 Extracellular (Potential). FT TRANSMEM 82 102 1 (Potential). FT DOMAIN 103 119 Cytoplasmic (Potential). FT TRANSMEM 120 140 2 (Potential). FT DOMAIN 141 156 Extracellular (Potential). FT TRANSMEM 157 177 3 (Potential). FT DOMAIN 178 215 Cytoplasmic (Potential). FT TRANSMEM 216 236 4 (Potential). FT DOMAIN 237 270 Extracellular (Potential). FT TRANSMEM 271 291 5 (Potential). FT DOMAIN 292 298 Cytoplasmic (Potential). FT TRANSMEM 299 319 6 (Potential). FT DOMAIN 320 332 Extracellular (Potential). FT TRANSMEM 333 353 7 (Potential). FT DOMAIN 354 472 Cytoplasmic (Potential). FT DOMAIN 67 70 Poly-Gly. FT DOMAIN 308 311 Poly-Ala. FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CARBOHYD 40 40 N-linked (GlcNAc...) (Potential). FT DISULFID 155 247 By similarity. SQ SEQUENCE 472 AA; 51573 MW; A0688FCBE06022B1 CRC64; MQVASATPAA TVRKAAAGDE LSEFFALTPD LLEVANASGN ASLQLQDLWW ELGLELPDGA APGHPPGGGG AESTDTEARV RILISAVYWV VCALGLAGNL LVLYLMKSKQ GWRKSSINLF VTNLALTDFQ FVLTLPFWAV ENALDFKWPF GKAMCKIVSM VTSMNMYASV FFLTAMSVAR YHSVASALKS HRTRGRGRGD CCGQSLRESC CFSAKVLCGL IWASAALASL PNAIFSTTIR VLGEELCLMH FPDKLLGWDR QFWLGLYHLQ KVLLGFLLPL SIISLCYLLL VRFISDRRVV GTTDAVGAAA APGGGLSTAS ARRRSKVTKS VTIVVLSFFL CWLPNQALTT WSILIKFNAV PFSQEYFQCQ VYAFPVSVCL AHSNSCLNPI LYCLVRREFR KALKNLLWRI ASPSLTNMRP FTATTKPEPE DHGLQALAPL NAAAEPDLIY YPPGVVVYSG GRYDLLPSSS AY // ID R3R1_HUMAN STANDARD; PRT; 469 AA. AC Q9NSD7; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Relaxin 3 receptor 1 (Somatostatin- and angiogenin-like peptide DE receptor) (G-protein coupled receptor SALPR) (GPCR135). GN SALPR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain cortex; RX MEDLINE=20267860; PubMed=10806363; RA Matsumoto M., Kamohara M., Sugimoto T., Hidaka K., Takasaki J., RA Saito T., Okada M., Yamaguchi T., Furuichi K.; RT "The novel G-protein coupled receptor SALPR shares sequence similarity RT with somatostatin and angiotensin receptors."; RL Gene 248:183-189(2000). RN [2] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A., AND FUNCTION. RX PubMed=14522968; RA Liu C., Eriste E., Sutton S., Chen J., Roland B., Kuei C., Farmer N., RA Joernvall H., Sillard R., Lovenberg T.W.; RT "Identification of relaxin-3/INSL7 as an endogenous ligand for the RT orphan G-protein coupled receptor GPCR135."; RL J. Biol. Chem. 278:50754-50764(2003). CC -!- FUNCTION: Receptor for relaxin-3. Binding of the ligand inhibit CC cAMP accumulation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed predominantly in brain regions. CC Highest expression in substantia nigra and pituitary, followed by CC hippocampus, spinal cord, amygdala, caudate nucleus and corpus CC callosum, quite low level in cerebellum. In peripheral tissues, CC relatively high levels in adrenal glands, low levels in pancreas, CC salivery gland, placenta, mammary gland and testis. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D88437; BAA93001.1; -. DR EMBL; AY236541; AAO92063.1; -. DR EMBL; AY394501; AAQ92315.1; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 81 Extracellular (Potential). FT TRANSMEM 82 102 1 (Potential). FT DOMAIN 103 119 Cytoplasmic (Potential). FT TRANSMEM 120 140 2 (Potential). FT DOMAIN 141 156 Extracellular (Potential). FT TRANSMEM 157 177 3 (Potential). FT DOMAIN 178 215 Cytoplasmic (Potential). FT TRANSMEM 216 236 4 (Potential). FT DOMAIN 237 270 Extracellular (Potential). FT TRANSMEM 271 291 5 (Potential). FT DOMAIN 292 329 Cytoplasmic (Potential). FT TRANSMEM 330 350 6 (Potential). FT DOMAIN 351 356 Extracellular (Potential). FT TRANSMEM 357 377 7 (Potential). FT DOMAIN 378 469 Cytoplasmic (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CARBOHYD 40 40 N-linked (GlcNAc...) (Potential). FT DISULFID 155 247 By similarity. SQ SEQUENCE 469 AA; 51123 MW; 932E7B3001689F7B CRC64; MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW ELGLELPDGA PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL LVLYLMKSMQ GWRKSSINLF VTNLALTDFQ FVLTLPFWAV ENALDFKWPF GKAMCKIVSM VTSMNMYASV FFLTAMSVTR YHSVASALKS HRTRGHGRGD CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK VMGEELCLVR FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI LIKFNAVPFS QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL KSLLWRIASP SITSMRPFTA TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP GVVVYSGGRY DLLPSSSAY // ID FMLR_MOUSE STANDARD; PRT; 364 AA. AC P33766; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) DE (FPR) (N-formylpeptide chemoattractant receptor). GN FPR1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94064602; PubMed=8244972; RA Gao J.-L., Murphy P.M.; RT "Species and subtype variants of the N-formyl peptide chemotactic RT receptor reveal multiple important functional domains."; RL J. Biol. Chem. 268:25395-25401(1993). CC -!- FUNCTION: HIGH AFFINITY RECEPTOR FOR N-FORMYL-METHIONYL PEPTIDES, CC WHICH ARE POWERFUL NEUTROPHILS CHEMOTACTIC FACTORS. BINDING OF CC FMLP TO THE RECEPTOR CAUSES ACTIVATION OF NEUTROPHILS. THIS CC RESPONSE IS MEDIATED VIA A G-PROTEIN THAT ACTIVATES A CC PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L22181; AAA16110.1; -. DR MGD; MGI:107443; Fpr1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Chemotaxis. FT DOMAIN 1 35 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 36 58 1 (POTENTIAL). FT DOMAIN 59 69 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 70 91 2 (POTENTIAL). FT DOMAIN 92 108 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 109 129 3 (POTENTIAL). FT DOMAIN 130 148 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 149 170 4 (POTENTIAL). FT DOMAIN 171 216 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 217 237 5 (POTENTIAL). FT DOMAIN 238 253 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 254 277 6 (POTENTIAL). FT DOMAIN 278 296 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 297 316 7 (POTENTIAL). FT DOMAIN 317 364 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 10 10 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 106 187 POTENTIAL. SQ SEQUENCE 364 AA; 40327 MW; 2F59193CF1D74DB2 CRC64; MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL GNGLVIWVAG FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP FGWFMCKFIY TVIDINLFGS VFLIALIALD RCICVLHPVW AQNHRTVSLA KKVIIVPWIC AFLLTLPVII RLTTVPNSRL GPGKTACTFD FSPWTKDPVE KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH RQGLIKSSRP LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG TNSTSLSENT LNAM // ID CCKR_RAT STANDARD; PRT; 444 AA. AC P30551; DT 01-APR-1993 (Rel. 25, Created) DT 01-APR-1993 (Rel. 25, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Cholecystokinin type A receptor (CCK-A receptor) (CCK-AR). GN CCKAR. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 111-158; 270-314 AND 392-402. RC TISSUE=Pancreas; RX MEDLINE=92212981; PubMed=1313582; RA Wank S.A., Harkins R., Jensen R.T., Shapira H., de Weerth A., RA Slattery T.; RT "Purification, molecular cloning, and functional expression of the RT cholecystokinin receptor from rat pancreas."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3125-3129(1992). RN [2] RP SEQUENCE FROM N.A., TISSUE SPECIFICITY, AND FUNCTION. RX MEDLINE=95382845; PubMed=7654260; RA Takata Y., Takiguchi S., Funakoshi A., Kono A.; RT "Gene structure of rat cholecystokinin type-A receptor."; RL Biochem. Biophys. Res. Commun. 213:958-966(1995). RN [3] RP DISULFIDE BONDS. RX MEDLINE=22798228; PubMed=12916469; RA Ding X.Q., Dolu V., Hadac E.M., Schuetz M., Miller L.J.; RT "Disulfide bond structure and accessibility of cysteines in the RT ectodomain of the cholecystokinin receptor: specific mono-reactive RT receptor constructs examine charge-sensitivity of loop regions."; RL Recept. Channels 9:83-91(2003). RN [4] RP ANTAGONIST BINDING. RX PubMed=8024583; RA Mantamadiotis T., Baldwin G.S.; RT "The seventh transmembrane domain of gastrin/CCK receptors contributes RT to non-peptide antagonist binding."; RL Biochem. Biophys. Res. Commun. 201:1382-1389(1994). CC -!- FUNCTION: Receptor for cholecystokinin. Mediates pancreatic CC growth and enzyme secretion, smooth muscle contraction of the CC gallbladder and stomach. Has a 1000-fold higher affinity for CCK CC rather than for gastrin. It modulates feeding and dopamine-induced CC behavior in the central and peripheral nervous system. This CC receptor mediates its action by association with G proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Pancreas and brain. Also expressed in CC the gastrointestinal system and vagus nerve. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M88096; AAA40899.1; -. DR EMBL; D50608; BAA09170.1; -. DR PIR; A42685; A42685. DR HSSP; P32238; 1HZN. DR RGD; 2289; Cckar. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01822; CCYSTOKININR. DR PRINTS; PR00524; CCYSTOKNINAR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Direct protein sequencing. FT DOMAIN 1 56 Extracellular (Potential). FT TRANSMEM 57 82 1 (Potential). FT DOMAIN 83 92 Cytoplasmic (Potential). FT TRANSMEM 93 119 2 (Potential). FT DOMAIN 120 130 Extracellular (Potential). FT TRANSMEM 131 152 3 (Potential). FT DOMAIN 153 172 Cytoplasmic (Potential). FT TRANSMEM 173 193 4 (Potential). FT DOMAIN 194 225 Extracellular (Potential). FT TRANSMEM 226 249 5 (Potential). FT DOMAIN 250 329 Cytoplasmic (Potential). FT TRANSMEM 330 350 6 (Potential). FT DOMAIN 351 365 Extracellular (Potential). FT TRANSMEM 366 389 7 (Potential). FT DOMAIN 390 444 Cytoplasmic (Potential). FT DISULFID 33 44 FT CARBOHYD 25 25 N-linked (GlcNAc...) (Potential). FT CARBOHYD 39 39 N-linked (GlcNAc...) (Potential). FT CARBOHYD 205 205 N-linked (GlcNAc...) (Potential). FT DISULFID 129 211 By similarity. FT LIPID 403 403 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 444 AA; 49657 MW; B435BE7505C2FB11 CRC64; MSHSPARQHL VESSRMDVVD SLLMNGSNIT PPCELGLENE TLFCLDQPQP SKEWQSALQI LLYSIIFLLS VLGNTLVITV LIRNKRMRTV TNIFLLSLAV SDLMLCLFCM PFNLIPNLLK DFIFGSAVCK TTTYFMGTSV SVSTFNLVAI SLERYGAICR PLQSRVWQTK SHALKVIAAT WCLSFTIMTP YPIYSNLVPF TKNNNQTANM CRFLLPSDAM QQSWQTFLLL ILFLLPGIVM VVAYGLISLE LYQGIKFDAS QKKSAKEKKP STGSSTRYED SDGCYLQKSR PPRKLELQQL SSGSGGSRLN RIRSSSSAAN LIAKKRVIRM LIVIVVLFFL CWMPIFSANA WRAYDTVSAE KHLSGTPISF ILLLSYTSSC VNPIIYCFMN KRFRLGFMAT FPCCPNPGPP GVRGEVGEEE DGRTIRALLS RYSYSHMSTS APPP // ID NK2R_HUMAN STANDARD; PRT; 398 AA. AC P21452; Q9UDE7; DT 01-MAY-1991 (Rel. 18, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Substance-K receptor (SKR) (Neurokinin A receptor) (NK-2 receptor) DE (NK-2R) (Tachykinin receptor 2). GN TACR2 OR TAC2R OR NK2R. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Stomach, and Trachea; RX MEDLINE=91056095; PubMed=2173708; RA Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.; RT "The human neurokinin A (substance K) receptor. Molecular cloning of RT the gene, chromosome localization, and isolation of cDNA from RT tracheal and gastric tissues."; RL J. Biol. Chem. 265:20455-20462(1990). RN [2] RP ERRATUM. RX MEDLINE=91093253; PubMed=1845990; RA Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.; RL J. Biol. Chem. 266:1354-1354(1991). RN [3] RP SEQUENCE FROM N.A., AND VARIANT THR-23. RC TISSUE=Lung; RX MEDLINE=91254341; PubMed=1710456; RA Graham A., Hopkins B., Powell S.J., Danks P., Briggs I.; RT "Isolation and characterisation of the human lung NK-2 receptor gene RT using rapid amplification of cDNA ends."; RL Biochem. Biophys. Res. Commun. 177:8-16(1991). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=92060616; PubMed=1659296; RA Gerard N.P., Gerard C.; RT "Molecular cloning of the human neurokinin-2 receptor cDNA by RT polymerase chain reaction and isolation of the gene."; RL Ann. N. Y. Acad. Sci. 632:389-390(1991). RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Stomach; RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide CC substance K (neurokinin A). It is associated with G proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- MISCELLANEOUS: The rank order of affinity of this receptor to CC tachykinins is: substance K > neuromedin K > substance P. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to other tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M57414; AAC31760.1; -. DR EMBL; M60284; AAA60347.1; -. DR EMBL; M57415; AAA60347.1; JOINED. DR EMBL; M60281; AAA60347.1; JOINED. DR EMBL; M60282; AAA60347.1; JOINED. DR EMBL; M60283; AAA60347.1; JOINED. DR EMBL; M75105; AAB05897.1; -. DR EMBL; M75101; AAB05897.1; JOINED. DR EMBL; M75102; AAB05897.1; JOINED. DR EMBL; M75103; AAB05897.1; JOINED. DR EMBL; M75104; AAB05897.1; JOINED. DR EMBL; AY322545; AAP84358.1; -. DR PIR; JQ1059; JQ1059. DR HSSP; P02699; 1F88. DR Genew; HGNC:11527; TACR2. DR MIM; 162321; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004995; F:tachykinin receptor activity; TAS. DR GO; GO:0007588; P:excretion; TAS. DR GO; GO:0006936; P:muscle contraction; TAS. DR GO; GO:0007217; P:tachykinin signaling pathway; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01025; NEUROKININ2R. DR PRINTS; PR00244; NEUROKININR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate; Polymorphism. FT DOMAIN 1 32 Extracellular (Potential). FT TRANSMEM 33 56 1 (Potential). FT DOMAIN 57 69 Cytoplasmic (Potential). FT TRANSMEM 70 90 2 (Potential). FT DOMAIN 91 107 Extracellular (Potential). FT TRANSMEM 108 129 3 (Potential). FT DOMAIN 130 149 Cytoplasmic (Potential). FT TRANSMEM 150 170 4 (Potential). FT DOMAIN 171 196 Extracellular (Potential). FT TRANSMEM 197 218 5 (Potential). FT DOMAIN 219 251 Cytoplasmic (Potential). FT TRANSMEM 252 272 6 (Potential). FT DOMAIN 273 290 Extracellular (Potential). FT TRANSMEM 291 310 7 (Potential). FT DOMAIN 311 398 Cytoplasmic (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT DISULFID 106 181 By similarity. FT LIPID 324 324 S-palmitoyl cysteine (Potential). FT VARIANT 23 23 I -> T (in dbSNP:5030920). FT /FTId=VAR_016159. FT VARIANT 375 375 R -> H (in dbSNP:2229170). FT /FTId=VAR_014680. FT CONFLICT 38 38 T -> P (in Ref. 1). SQ SEQUENCE 398 AA; 44439 MW; 7AF15BB1372463A1 CRC64; MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG NAIVIWIILA HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA VIAGIWLVAL ALASPQCFYS TVTMDQGATK CVVAWPEDSG GKTLLLYHLV VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR HLQAKKKFVK TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR CHTKETLFMA GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI // ID GASR_RAT STANDARD; PRT; 452 AA. AC P30553; DT 01-APR-1993 (Rel. 25, Created) DT 01-APR-1993 (Rel. 25, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR). GN CCKBR. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=92409582; PubMed=1528881; RA Wank S.A., Pisegna J.R., de Weerth A.; RT "Brain and gastrointestinal cholecystokinin receptor family: RT structure and functional expression."; RL Proc. Natl. Acad. Sci. U.S.A. 89:8691-8695(1992). CC -!- FUNCTION: RECEPTOR FOR GASTRIN AND CHOLECYSTOKININ. THE CKK-B CC RECEPTORS OCCUR THROUGHOUT THE CENTRAL NERVOUS SYSTEM WHERE THEY CC MODULATE ANXIETY, ANALGESIA, AROUSAL, AND NEUROLEPTIC ACTIVITY. CC THIS RECEPTOR MEDIATES ITS ACTION BY ASSOCIATION WITH G PROTEINS CC THAT ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER CC SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Parietal cells, pancreas, brain and various CC neoplastic tissues. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M99418; AAA40925.1; -. DR PIR; A46195; A46195. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 57 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 58 79 1 (POTENTIAL). FT DOMAIN 80 87 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 88 109 2 (POTENTIAL). FT DOMAIN 110 131 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 132 150 3 (POTENTIAL). FT DOMAIN 151 170 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 171 189 4 (POTENTIAL). FT DOMAIN 190 219 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 220 242 5 (POTENTIAL). FT DOMAIN 243 338 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 339 360 6 (POTENTIAL). FT DOMAIN 361 378 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 379 399 7 (POTENTIAL). FT DOMAIN 400 452 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 7 7 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 30 30 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 36 36 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 127 205 BY SIMILARITY. FT LIPID 413 413 S-palmitoyl cysteine (By similarity). FT DOMAIN 221 226 POLY-LEU. SQ SEQUENCE 452 AA; 48956 MW; 006D811A6AA065C6 CRC64; MELLKLNRSV QGPGPGSGSS LCRPGVSLLN SSSAGNLSCD PPRIRGTGTR ELEMAIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF IFGTVICKAI SYLMGVSVSV STLNLVAIAL ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTMVQPVGP RVLQCMHRWP SARVQQTWSV LLLLLLFFIP GVVIAVAYGL ISRELYLGLH FDGENDSETQ SRARNQGGLP GGAAPGPVHQ NGGCRPVTSV AGEDSDGCCV QLPRSRLEMT TLTTPTPGPV PGPRPNQAKL LAKKRVVRML LVIVLLFFLC WLPVYSVNTW RAFDGPGAQR ALSGAPISFI HLLSYVSACV NPLVYCFMHR RFRQACLDTC ARCCPRPPRA RPQPLPDEDP PTPSIASLSR LSYTTISTLG PG // ID NFF1_RAT STANDARD; PRT; 432 AA. AC Q9EP86; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Neuropeptide FF receptor 1 (RFamide-related peptide receptor OT7T022). GN NPFF1. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A., AND TISSUE SPECIFICITY. RC TISSUE=Brain stem; RX MEDLINE=20482175; PubMed=11025660; RA Hinuma S., Shintani Y., Fukusumi S., Iijima N., Matsumoto Y., RA Hosoya M., Fujii R., Watanabe T., Kikuchi K., Terao Y., Yano T., RA Yamamoto T., Kawamata Y., Habata Y., Asada M., Kitada C., Kurokawa T., RA Onda H., Nishimura O., Tanaka M., Ibata Y., Fujino M.; RT "New neuropeptides containing carboxy-terminal RFamide and their RT receptor in mammals."; RL Nat. Cell Biol. 2:703-708(2000). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Hypothalamus; RX MEDLINE=20564301; PubMed=11024015; RA Bonini J.A., Jones K.A., Adham N., Forray C., Artymyshyn R., RA Durkin M.M., Smith K.E., Tamm J.A., Boteju L.W., Lakhlani P.P., RA Raddatz R., Yao W.-J., Ogozalek K.L., Boyle N., Kouranova E.V., RA Quan Y., Vaysse P.J., Wetzel J.M., Branchek T.A., Gerald C., RA Borowsky B.; RT "Identification and characterization of two G protein-coupled RT receptors for neuropeptide FF."; RL J. Biol. Chem. 275:39324-39331(2000). CC -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) CC neuropeptides, also known as morphine-modulating peptides. Can CC also be activated by a variety of naturally ocurring or synthetic CC FMRF-amide like ligands. This receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed at high levels in the hypothalamus. CC Moderate levels found in the midbrain, thalamus, medulla CC oblongata, testis, eye, whole brain, cerebral cortex, striatum, CC hippocampus, cerebellum, optic nerve, placenta, spinal cord, CC pituitary gland and ovary. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB040103; BAB17676.1; -. DR EMBL; AF268901; AAG41400.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005395; NPFF_receptor. DR InterPro; IPR005396; NPFF_receptor1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01570; NPFFRECEPTOR. DR PRINTS; PR01571; NPFFRECEPTR1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 43 Extracellular (Potential). FT TRANSMEM 44 64 1 (Potential). FT DOMAIN 65 80 Cytoplasmic (Potential). FT TRANSMEM 81 101 2 (Potential). FT DOMAIN 102 117 Extracellular (Potential). FT TRANSMEM 118 138 3 (Potential). FT DOMAIN 139 158 Cytoplasmic (Potential). FT TRANSMEM 159 179 4 (Potential). FT DOMAIN 180 214 Extracellular (Potential). FT TRANSMEM 215 235 5 (Potential). FT DOMAIN 236 273 Cytoplasmic (Potential). FT TRANSMEM 274 294 6 (Potential). FT DOMAIN 295 309 Extracellular (Potential). FT TRANSMEM 310 330 7 (Potential). FT DOMAIN 331 432 Cytoplasmic (Potential). FT DISULFID 116 203 By similarity. FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 113 113 N-linked (GlcNAc...) (Potential). FT CARBOHYD 195 195 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 432 AA; 48323 MW; 827325849444C408 CRC64; MEAEPSQPPN GSWPLGQNGS DVETSMATSL TFSSYYQHSS PVAAMFIAAY VLIFLLCMVG NTLVCFIVLK NRHMRTVTNM FILNLAVSDL LVGIFCMPTT LVDNLITGWP FDNATCKMSG LVQGMSVSAS VFTLVAIAVE RFRCIVHPFR EKLTLRKALF TIAVIWALAL LIMCPSAVTL TVTREEHHFM LDARNRSYPL YSCWEAWPEK GMRKVYTAVL FAHIYLVPLA LIVVMYVRIA RKLCQAPGPA RDTEEAVAEG GRTSRRRARV VHMLVMVALF FTLSWLPLWV LLLLIDYGEL SELQLHLLSV YAFPLAHWLA FFHSSANPII YGYFNENFRR GFQAAFRAQL CWPPWAAHKQ AYSERPNRLL RRRVVVDVQP SDSGLPSESG PSSGVPGPGR LPLRNGRVAH QDGPGEGPGC NHMPLTIPAW NI // ID GALR_MOUSE STANDARD; PRT; 348 AA. AC P56479; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Galanin receptor type 1 (GAL1-R) (GALR1). GN GALR1 OR GALNR1 OR GALNR. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=97415411; PubMed=9271210; RA Wang S., He C., Maguire M.T., Clemmons A.L., Burrier R.E., Guzzi M.F., RA Strader C.D., Parker E.M., Bayne M.L.; RT "Genomic organization and functional characterization of the mouse RT GalR1 galanin receptor."; RL FEBS Lett. 411:225-230(1997). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=129; RX MEDLINE=98035873; PubMed=9367674; RA Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., RA Bottema C.D.K., Shine J., Iismaa T.P.; RT "Structural organization of the mouse and human GALR1 galanin RT receptor genes (Galnr and GALNR) and chromosomal localization of the RT mouse gene."; RL Genomics 45:496-508(1997). CC -!- FUNCTION: Receptor for the hormone galanin. The activity of this CC receptor is mediated by G proteins that inhibit adenylate cyclase CC activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: THREE CYSTEINE RESIDUES ARE FOUND IN THE C-TERMINUS, AT LEAST CC ONE OF WHICH MAY BE PALMITOYLATED (BY SIMILARITY). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y15004; CAA75237.1; -. DR EMBL; U90657; AAB87748.1; -. DR EMBL; U90655; AAB87748.1; JOINED. DR EMBL; U90656; AAB87748.1; JOINED. DR MGD; MGI:1096364; Galr1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 34 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 35 55 1 (POTENTIAL). FT DOMAIN 56 70 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 71 91 2 (POTENTIAL). FT DOMAIN 92 109 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 110 131 3 (POTENTIAL). FT DOMAIN 132 151 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 152 172 4 (POTENTIAL). FT DOMAIN 173 197 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 198 218 5 (POTENTIAL). FT DOMAIN 219 247 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 248 268 6 (POTENTIAL). FT DOMAIN 269 270 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 271 291 7 (POTENTIAL). FT DOMAIN 292 348 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 7 7 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 12 12 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 182 182 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 108 186 BY SIMILARITY. FT LIPID 319 319 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 348 AA; 39114 MW; 6F52D752BAA19F9A CRC64; MELAMVNLSE GNGSDPEPPA PESRPLFGIG VENFITLVVF GLIFAMGVLG NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGFIW ALSIAMASPV AYHQRLFHRD SNQTFCWEQW PNKLHKKAYV VCTFVFGYLL PLLLICFCYA KVLNHLHKKL KNMSKKSEAS KKKTAQTVLV VVVVFGISWL PHHVVHLWAE FGAFPLTPAS FFFRITAHCL AYSNSSVNPI IYAFLSENFR KAYKQVFKCH VCDESPRSET KENKSRMDTP PSTNCTHV // ID NFF2_MOUSE STANDARD; PRT; 417 AA. AC Q924H0; Q8BKR6; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Neuropeptide FF receptor 2 (Neuropeptide NPFF receptor) (G protein- DE coupled receptor 74). GN GPR74 OR NPFF2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RA Liu Q., Guan X.-M., McDonald T.P., Jiang Q., Zeng Z., Marlene J., RA Williams D.L. Jr., Hong Y., Figueroa D., Clements M.K., Mallee J., RA Wang R., Evans J., Gould R., Austin C.P.; RT "Identification and characterization of two cognate receptors for RT mammalian FMRFamide-like neuropeptides."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6J; RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). CC -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) CC neuropeptides, also known as morphine-modulating peptides. Can CC also be activated by a variety of naturally ocurring or synthetic CC FMRF-amide like ligands. This receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF330054; AAK94198.1; -. DR EMBL; AK050939; BAC34468.1; -. DR MGD; MGI:1860130; Gpr74. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005395; NPFF_receptor. DR InterPro; IPR005397; NPFF_receptor2. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01570; NPFFRECEPTOR. DR PRINTS; PR01572; NPFFRECEPTR2. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 45 Extracellular (Potential). FT TRANSMEM 46 66 1 (Potential). FT DOMAIN 67 82 Cytoplasmic (Potential). FT TRANSMEM 83 103 2 (Potential). FT DOMAIN 104 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT DOMAIN 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT DOMAIN 182 217 Extracellular (Potential). FT TRANSMEM 218 238 5 (Potential). FT DOMAIN 239 274 Cytoplasmic (Potential). FT TRANSMEM 275 295 6 (Potential). FT DOMAIN 296 310 Extracellular (Potential). FT TRANSMEM 311 331 7 (Potential). FT DOMAIN 332 417 Cytoplasmic (Potential). FT DISULFID 118 206 By similarity. FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT CARBOHYD 198 198 N-linked (GlcNAc...) (Potential). FT CONFLICT 89 89 I -> T (in Ref. 1). FT CONFLICT 260 260 V -> E (in Ref. 1). FT CONFLICT 368 368 I -> M (in Ref. 1). SQ SEQUENCE 417 AA; 47449 MW; BB8D85EF405D5786 CRC64; MSEKWDSNSS ESWNHIWSGN DTQHHWYSDI NITYVNYYLH QPQVAAVFIS SYLLIFVLCM VGNTVVCFIV IRNRHMHTVT NFFILNLAIS DLLVGIFCMP ITLLDNIIAG WPFGSSMCKI SGLVQGISVA ASVFTLVAIA VDRFRCVVYP FKPKLTVKTA FVTIVIIWGL AIAIMTPSAI MLHVQEEKYY RVRLSSHNKT STVYWCREDW PRHEMRRIYT TVLFATIYLA PLSLIVIMYA RIGASLFKTA AHCTGKQRPV QWHVSKKKQK VIKMLLTVAL LFILSWLPLW TLMMLSDYTD LSPNKLRIIN IYIYPFAHWL AFCNSSVNPI IYGFFNENFR NGFQDAFQIC QKKAKPQEAY SLRAKRNIVI NTSGLLVQEP VSQNPGGENL GCGKSADNPT QESLIEEMGE ATNSTVA // ID NFF2_HUMAN STANDARD; PRT; 522 AA. AC Q9Y5X5; Q96RV1; Q9NR49; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Neuropeptide FF receptor 2 (Neuropeptide G protein-coupled receptor) DE (G protein-coupled receptor 74) (G-protein-coupled receptor HLWAR77). GN GPR74 OR NPGPR OR NPFF2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Fetal; RX MEDLINE=99180505; PubMed=10079187; RA Cikos S., Gregor P., Koppel J.; RT "Sequence and tissue distribution of a novel G-protein-coupled RT receptor expressed prominently in human placenta."; RL Biochem. Biophys. Res. Commun. 256:352-356(1999). RN [2] RP SEQUENCE FROM N.A. (ISOFORM 2), AND CHARACTERIZATION. RC TISSUE=Brain; RX MEDLINE=20408933; PubMed=10851242; RA Elshourbagy N.A., Ames R.S., Fitzgerald L.R., Foley J.J., RA Chambers J.K., Szekeres P.G., Evans N.A., Schmidt D.B., Buckley P.T., RA Dytko G.M., Murdock P.R., Milligan G., Groarke D.A., Tan K.B., RA Shabon U., Nuthulaganti P., Wang D.Y., Wilson S., Bergsma D.J., RA Sarau H.M.; RT "Receptor for the pain modulatory neuropeptides FF and AF is an orphan RT G protein-coupled receptor."; RL J. Biol. Chem. 275:25965-25971(2000). RN [3] RP SEQUENCE FROM N.A. (ISOFORM 2), AND CHARACTERIZATION. RC TISSUE=Spinal cord; RX MEDLINE=20564301; PubMed=11024015; RA Bonini J.A., Jones K.A., Adham N., Forray C., Artymyshyn R., RA Durkin M.M., Smith K.E., Tamm J.A., Boteju L.W., Lakhlani P.P., RA Raddatz R., Yao W.-J., Ogozalek K.L., Boyle N., Kouranova E.V., RA Quan Y., Vaysse P.J., Wetzel J.M., Branchek T.A., Gerald C., RA Borowsky B.; RT "Identification and characterization of two G protein-coupled RT receptors for neuropeptide FF."; RL J. Biol. Chem. 275:39324-39331(2000). RN [4] RP SEQUENCE FROM N.A. (ISOFORM 3). RX MEDLINE=20299143; PubMed=10837915; RA Parker R.M.C., Copeland N.G., Eyre H.J., Liu M., Gilbert D.J., RA Crawford J., Couzens M., Sutherland G.R., Jenkins N.A., Herzog H.; RT "Molecular cloning and characterisation of GPR74 a novel G-protein RT coupled receptor closest related to the Y-receptor family."; RL Brain Res. Mol. Brain Res. 77:199-208(2000). RN [5] RP SEQUENCE FROM N.A. (ISOFORM 2). RA Liu Q., Guan X.-M., McDonald T.P., Jiang Q., Zeng Z., Marlene J., RA Williams D.L. Jr., Hong Y., Figueroa D., Clements M.K., Mallee J., RA Wang R., Evans J., Gould R., Austin C.P.; RT "Identification and characterization of two cognate receptors for RT mammalian FMRFamide-like neuropeptides."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE FROM N.A. (ISOFORM 4). RA Laemmle B.S., Schindler M., Beilmann M., Hamilton B.S., Doods H.N., RA Wieland H.A.; RT "Cloning and characterization of the NPGP receptor and identification RT of a novel short mRNA isoform in human hypothalamus."; RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) CC neuropeptides, also known as morphine-modulating peptides. Can CC also be activated by a variety of naturally ocurring or synthetic CC FMRF-amide like ligands. This receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Comment=Experimental confirmation may be lacking for some CC isoforms; CC Name=1; Synonyms=long form; CC IsoId=Q9Y5X5-1; Sequence=Displayed; CC Name=2; Synonyms=short form; CC IsoId=Q9Y5X5-2; Sequence=VSP_001907; CC Name=3; CC IsoId=Q9Y5X5-3; Sequence=VSP_001908, VSP_001909; CC Name=4; CC IsoId=Q9Y5X5-4; Sequence=VSP_001910, VSP_001911; CC -!- TISSUE SPECIFICITY: Isoform 1 is abundant in placenta. Relatively CC highly expressed in thymus, testis, and small intestine. Expressed CC at low levels in several tissues including spleen, prostate, CC brain, heart, ovary, colon, kidney, lung, liver and pancreas and CC not expressed in skeletal muscle and leukocytes. Highest but CC relatively low level of isoform 2 in placenta and very low level CC in numerous tissues including adipose tissue and many brain CC regions. Isoform 3 is expressed in brain and heart and, at lower CC levels, in kidney, liver, lung and pancreas. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- CAUTION: Ref.4 sequence differs from that shown due to a CC frameshift in position 503. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF119815; AAD22047.1; -. DR EMBL; AF257210; AAF87078.1; -. DR EMBL; AF268899; AAG41398.1; -. DR EMBL; AF236083; AAK58513.1; ALT_FRAME. DR EMBL; AF330053; AAK94197.1; -. DR EMBL; AJ311393; CAC85427.1; -. DR Genew; HGNC:4525; GPR74. DR MIM; 607449; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0008151; P:cell growth and/or maintenance; TAS. DR GO; GO:0009582; P:detection of abiotic stimulus; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005395; NPFF_receptor. DR InterPro; IPR005397; NPFF_receptor2. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01570; NPFFRECEPTOR. DR PRINTS; PR01572; NPFFRECEPTR2. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Alternative splicing. FT DOMAIN 1 147 Extracellular (Potential). FT TRANSMEM 148 168 1 (Potential). FT DOMAIN 169 184 Cytoplasmic (Potential). FT TRANSMEM 185 205 2 (Potential). FT DOMAIN 206 221 Extracellular (Potential). FT TRANSMEM 222 242 3 (Potential). FT DOMAIN 243 262 Cytoplasmic (Potential). FT TRANSMEM 263 283 4 (Potential). FT DOMAIN 284 319 Extracellular (Potential). FT TRANSMEM 320 340 5 (Potential). FT DOMAIN 341 377 Cytoplasmic (Potential). FT TRANSMEM 378 398 6 (Potential). FT DOMAIN 399 413 Extracellular (Potential). FT TRANSMEM 414 434 7 (Potential). FT DOMAIN 435 522 Cytoplasmic (Potential). FT DISULFID 220 308 By similarity. FT CARBOHYD 110 110 N-linked (GlcNAc...) (Potential). FT CARBOHYD 122 122 N-linked (GlcNAc...) (Potential). FT CARBOHYD 133 133 N-linked (GlcNAc...) (Potential). FT CARBOHYD 300 300 N-linked (GlcNAc...) (Potential). FT VARSPLIC 1 102 Missing (in isoform 2). FT /FTId=VSP_001907. FT VARSPLIC 1 99 Missing (in isoform 3). FT /FTId=VSP_001908. FT VARSPLIC 100 100 R -> M (in isoform 3). FT /FTId=VSP_001909. FT VARSPLIC 101 132 FIMNEKWDTNSSENWHPIWNVNDTKHHLYSDI -> MAIWK FT HDVQDQWIGPGNICRSFSLYVSCNCCR (in isoform FT 4). FT /FTId=VSP_001910. FT VARSPLIC 133 522 Missing (in isoform 4). FT /FTId=VSP_001911. FT CONFLICT 466 466 A -> T (in Ref. 1 and 4). SQ SEQUENCE 522 AA; 60270 MW; 40CB9FCD42F77041 CRC64; MNSFFGTPAA SWCLLESDVS SAPDKEAGRE RRALSVQQRG GPAWSGSLEW SRQSAGDRRR LGLSRQTAKS SWSRSRDRTC CCRRAWWILV PAADRARRER FIMNEKWDTN SSENWHPIWN VNDTKHHLYS DINITYVNYY LHQPQVAAIF IISYFLIFFL CMMGNTVVCF IVMRNKHMHT VTNLFILNLA ISDLLVGIFC MPITLLDNII AGWPFGNTMC KISGLVQGIS VAASVFTLVA IAVDRFQCVV YPFKPKLTIK TAFVIIMIIW VLAITIMSPS AVMLHVQEEK YYRVRLNSQN KTSPVYWCRE DWPNQEMRKI YTTVLFANIY LAPLSLIVIM YGRIGISLFR AAVPHTGRKN QEQWHVVSRK KQKIIKMLLI VALLFILSWL PLWTLMMLSD YADLSPNELQ IINIYIYPFA HWLAFGNSSV NPIIYGFFNE NFRRGFQEAF QLQLCQKRAK PMEAYALKAK SHVLINTSNQ LVQESTFQNP HGETLLYRKS AEKPQQELVM EELKETTNSS EI // ID NY1R_PIG STANDARD; PRT; 383 AA. AC O02835; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Neuropeptide Y receptor type 1 (NPY1-R). GN NPY1R. OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Hypothalamus; RX MEDLINE=99017380; PubMed=9802394; RA Malmstroem R.E., Hoekfelt T., Bjoerkman J.-A., Nihlen C., Bystroem M., RA Ekstrand A.J., Lundberg J.M.; RT "Characterization and molecular cloning of vascular neuropeptide Y RT receptor subtypes in pig and dog."; RL Regul. Pept. 75:55-70(1998). RN [2] RP SEQUENCE FROM N.A. RA Wraith A., Tornsten A., Chardon P., Harbitz I., Chowdhary B.P., RA Andersson L., Larhammar D.; RT "Porcine NPY receptors NPY1R, NPY2R and NPY5R: cloning, mapping and RT comparative analysis."; RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: RECEPTOR FOR NEUROPEPTIDE Y AND PEPTIDE YY. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF005779; AAC26836.1; -. DR EMBL; AF106081; AAD13776.2; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 39 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 40 62 1 (POTENTIAL). FT DOMAIN 63 72 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 73 94 2 (POTENTIAL). FT DOMAIN 95 114 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 115 136 3 (POTENTIAL). FT DOMAIN 137 156 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 157 177 4 (POTENTIAL). FT DOMAIN 178 210 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 211 232 5 (POTENTIAL). FT DOMAIN 233 263 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 264 286 6 (POTENTIAL). FT DOMAIN 287 299 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 300 323 7 (POTENTIAL). FT DOMAIN 324 383 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 11 11 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 17 17 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 113 198 BY SIMILARITY. FT LIPID 338 338 S-palmitoyl cysteine (Potential). FT CONFLICT 203 203 L -> P (IN REF. 2). SQ SEQUENCE 383 AA; 44327 MW; 0D58CBCA549B62CF CRC64; MNSTLSSQVE NHSIYYNFSE KNSQFLAFEN DDCHLPLAMI FTLALAYGAV IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY TLMDHWVFGE VMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP SNRHAYVGIA VIWVLAVASS LPFLIYQVLT DEPFQNVTLD AFKDKYVCFD KFLSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD NKYRSSETKR INVMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL LFLLCHLTAM ISTCINPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYEVI AMSTMHTDVS KTSLKQASPV ALKKIHSDDN EKI // ID NFF2_RAT STANDARD; PRT; 417 AA. AC Q9EQD2; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Neuropeptide FF receptor 2 (Neuropeptide G protein-coupled receptor) DE (G protein-coupled receptor 74). GN GPR74 OR NPGPR OR NPFF2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=20564301; PubMed=11024015; RA Bonini J.A., Jones K.A., Adham N., Forray C., Artymyshyn R., RA Durkin M.M., Smith K.E., Tamm J.A., Boteju L.W., Lakhlani P.P., RA Raddatz R., Yao W.-J., Ogozalek K.L., Boyle N., Kouranova E.V., RA Quan Y., Vaysse P.J., Wetzel J.M., Branchek T.A., Gerald C., RA Borowsky B.; RT "Identification and characterization of two G protein-coupled RT receptors for neuropeptide FF."; RL J. Biol. Chem. 275:39324-39331(2000). CC -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) CC neuropeptides, also known as morphine-modulating peptides. Can CC also be activated by a variety of naturally ocurring or synthetic CC FMRF-amide like ligands. This receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF268900; AAG41399.1; -. DR RGD; 620168; Npgpr. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005395; NPFF_receptor. DR InterPro; IPR005397; NPFF_receptor2. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01570; NPFFRECEPTOR. DR PRINTS; PR01572; NPFFRECEPTR2. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 45 Extracellular (Potential). FT TRANSMEM 46 66 1 (Potential). FT DOMAIN 67 82 Cytoplasmic (Potential). FT TRANSMEM 83 103 2 (Potential). FT DOMAIN 104 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT DOMAIN 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT DOMAIN 182 217 Extracellular (Potential). FT TRANSMEM 218 238 5 (Potential). FT DOMAIN 239 274 Cytoplasmic (Potential). FT TRANSMEM 275 295 6 (Potential). FT DOMAIN 296 310 Extracellular (Potential). FT TRANSMEM 311 331 7 (Potential). FT DOMAIN 332 417 Cytoplasmic (Potential). FT DISULFID 118 206 By similarity. FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT CARBOHYD 198 198 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 417 AA; 47710 MW; DFEB6AC63AF2AAD6 CRC64; MGKRWDSNSS GSWDHIWSGN DTQHPWYSDI NITYMNYYLH QPHVTAVFIS SYFLIFFLCM VGNTVVCFVV IRNRYMHTVT NFFIFNLAIS DLLVGIFCMP ITLLDNIIAG WPFGSSMCKI SGLVQGISVA ASVFTLVAIA VDRFRCVVYP FKPKLTVKTA FVMIVIIWGL AITIMTPSAI MLHVQEEKYY RVRLSSHNKT STVYWCREDW PNQEMRRIYT TVLFATIYLA PLSLIVIMYA RIGASLFKTS AHSTGKQRLE QWHVSKKKQK VIKMLLTVAL LFILSWLPLW TLMMLSDYAD LSPNKLRVIN IYVYPFAHWL AFCNSSVNPI IYGFFNENFR SGFQDAFQFC QKKVKPQEAY GLRAKRNLDI NTSGLLVHEP ASQNPSGENL GCRKSADNPT QESLMEETGE ATNSTET // ID NY1R_XENLA STANDARD; PRT; 366 AA. AC P34992; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Neuropeptide Y receptor type 1 (NPY1-R). OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus. OX NCBI_TaxID=8355; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Hypothalamus; RX MEDLINE=95260870; PubMed=7742373; RA Blomqvist A.G., Roubos E.W., Larhammar D., Martens G.J.; RT "Cloning and sequence analysis of a neuropeptide Y/peptide YY RT receptor Y1 cDNA from Xenopus laevis."; RL Biochim. Biophys. Acta 1261:439-441(1995). CC -!- FUNCTION: RECEPTOR FOR NEUROPEPTIDE Y AND PEPTIDE YY. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L25416; AAA49918.1; -. DR PIR; S71152; S71152. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 34 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 35 57 1 (POTENTIAL). FT DOMAIN 58 67 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 68 89 2 (POTENTIAL). FT DOMAIN 90 109 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 110 131 3 (POTENTIAL). FT DOMAIN 132 151 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 152 172 4 (POTENTIAL). FT DOMAIN 173 205 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 206 227 5 (POTENTIAL). FT DOMAIN 228 258 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 259 281 6 (POTENTIAL). FT DOMAIN 282 294 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 295 318 7 (POTENTIAL). FT DOMAIN 319 366 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 9 9 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 15 15 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 181 181 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 108 193 BY SIMILARITY. FT LIPID 333 333 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 366 AA; 42252 MW; B82C3C19A603FC67 CRC64; MNFSTYFENL SVPNNISGNI TFPISEDCAL PLPMIFTLAL AYGAVIILGL SGNLALIIII LKQKEMRNVT NILIVNLSFS DLLATIMCLP FTLIYTLMDH WIFGEVMCKL NEYIQCVSVT VSIFSLVLIA IERHQLIINP RGWRPNNRHA CFGITVIWGF AMACSTPLMM YSVLTDEPFK NISLDSYIGK YVCLEDFPED KFRLSYTTLL FILQYLGPLC FIFVCYTKIF LRLKRRNNMM DKIRDNKYRS SETKRINIML LSIVVGFALC WLPFFIFNLV FDWNHEAVAT CNHNLLFLIC HLTAMISTCV NPIFYGFLNK NFQRDLQFFF NFCDFRSRED DYETIAMSTM HTDVSKTSLK QASPIA // ID GP44_HUMAN STANDARD; PRT; 395 AA. AC Q9Y5Y4; O94765; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Putative G protein-coupled receptor GPR44 (Chemoattractant receptor- DE homologous molecule expressed on Th2 cells). GN GPR44 OR CRTH2 OR DL1R. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99156852; PubMed=10036181; RA Marchese A., Sawzdargo M., Nguyen T., Cheng R., Heng H.H., Nowak T., RA Im D.S., Lynch K.R., George S.R., O'dowd B.F.; RT "Discovery of three novel orphan G-protein-coupled receptors."; RL Genomics 56:12-21(1999). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Blood; RX MEDLINE=99138803; PubMed=9973380; RA Nagata K., Tanaka K., Ogawa K., Kemmotsu K., Imai T., Yoshie O., RA Abe H., Tada K., Nakamura M., Sugamura K., Takano S.; RT "Selective expression of a novel surface molecule by human Th2 cells RT in vivo."; RL J. Immunol. 162:1278-1286(1999). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RA Methner A., Schroeder S.; RT "Tissue expression and chromosomal organization of a novel G protein- RT coupled receptor."; RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: ORPHAN RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF118265; AAD21055.1; ALT_INIT. DR EMBL; AB008535; BAA74518.1; -. DR EMBL; AF144308; AAD34539.1; -. DR Genew; HGNC:4502; GPR44. DR MIM; 604837; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 33 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 34 56 1 (POTENTIAL). FT DOMAIN 57 67 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 68 89 2 (POTENTIAL). FT DOMAIN 90 106 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 107 127 3 (POTENTIAL). FT DOMAIN 128 146 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 147 168 4 (POTENTIAL). FT DOMAIN 169 210 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 211 231 5 (POTENTIAL). FT DOMAIN 232 247 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 248 269 6 (POTENTIAL). FT DOMAIN 270 288 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 289 308 7 (POTENTIAL). FT DOMAIN 309 395 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 25 25 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 104 182 POTENTIAL. FT CONFLICT 375 395 GSCAASPQTGPLNRALSSTSS -> VQLRSVPADGPPEPGA FT EQHLELEPGPRRAALTRESITRVPRFNSISGLLPQ (IN FT REF. 1). SQ SEQUENCE 395 AA; 43239 MW; 9DBBB53B2008C1D1 CRC64; MSANATLKPL CPILEQMSRL QSHSNTSIRY IDHAAVLLHG LASLLGLVEN GVILFVVGCR MRQTVVTTWV LHLALSDLLA SASLPFFTYF LAVGHSWELG TTFCKLHSSI FFLNMFASGF LLSAISLDRC LQVVRPVWAQ NHRTVAAAHK VCLVLWALAV LNTVPYFVFR DTISRLDGRI MCYYNVLLLN PGPDRDATCN SRQAALAVSK FLLAFLVPLA IIASSHAAVS LRLQHRGRRR PGRFVRLVAA VVAAFALCWG PYHVFSLLEA RAHANPGLRP LVWRGLPFVT SLAFFNSVAN PVLYVLTCPD MLRKLRRSLR TVLESVLVDD SELGGAGSSR RRRTSSTARS ASPLALCSRP EEPRGPARLL GWLLGSCAAS PQTGPLNRAL SSTSS // ID NY2R_MOUSE STANDARD; PRT; 385 AA. AC P97295; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor). GN NPY2R. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=97071731; PubMed=8914576; RA Nakamura M., Aoki Y., Hirano D.; RT "Cloning and functional expression of a cDNA encoding a mouse type 2 RT neuropeptide Y receptor."; RL Biochim. Biophys. Acta 1284:134-137(1996). CC -!- FUNCTION: RECEPTOR FOR NEUROPEPTIDE Y AND PEPTIDE YY. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D86238; BAA13050.1; -. DR MGD; MGI:108418; Npy2r. DR GO; GO:0001601; F:peptide YY receptor activity; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 53 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 54 76 1 (POTENTIAL). FT DOMAIN 77 86 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 87 108 2 (POTENTIAL). FT DOMAIN 109 128 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 129 150 3 (POTENTIAL). FT DOMAIN 151 170 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 171 191 4 (POTENTIAL). FT DOMAIN 192 218 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 219 244 5 (POTENTIAL). FT DOMAIN 245 272 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 273 295 6 (POTENTIAL). FT DOMAIN 296 308 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 309 332 7 (POTENTIAL). FT DOMAIN 333 385 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 15 15 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 127 207 BY SIMILARITY. FT LIPID 346 346 S-palmitoyl cysteine (Potential). SQ SEQUENCE 385 AA; 43099 MW; 5AD7E4C9B7077085 CRC64; MVLKMGPVGA EADENQTVEV KVEPYGPGHT TPRGELPPDP EPELIDSTKL VEVQVILILA YCSIILLGVV GNSLVIHVVI KFKSMRTVTN FFIANLAVAD LLVNTLCLPF TLTYTLMGEW KMGPVLCHLV PYAQGLAVQV STITLTVIAL DRHRCIVYHL ESKISKRISF LIIGLAWGIS ALLASPLAIF REYSLIEIIP DFEIVACTEK WPGEEKSVYG TVYSLSTLLI LYVLPLGIIS FSYTRIWSKL RNHVSPGAAS DHYHQRRHKM TKMLVCVVVV FAVSWLPLHA FQLAVDIDSH VLDLKEYKLI FTVFHIIAMC STFANPLLYG WMNSNYRKAF LSAFRCEQRL DAIHSEVSMT FKAKKNLEVK KNNGPTDSFS EATNV // ID MTR_BUFMA STANDARD; PRT; 389 AA. AC Q90252; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Mesotocin receptor (MTR). OS Bufo marinus (Giant toad) (Cane toad). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Bufo. OX NCBI_TaxID=8386; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Urinary bladder; RX MEDLINE=96235243; PubMed=8647123; RA Akhundova A., Getmanova E., Gorboulev V., Garnazzi E., Eggena P., RA Fahrenholz F.; RT "Cloning and functional characterization of the amphibian mesotocin RT receptor, a member of the oxytocin/vasopressin receptor superfamily."; RL Eur. J. Biochem. 237:759-767(1996). CC -!- FUNCTION: Binds to mesotocin and may play a role in the regulation CC of water and salt transport. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Highly expressed in the bladder. Also CC expressed in kidney, brain and skeletal muscle. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X93313; CAA63713.1; -. DR PIR; S71336; S71336. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Transmembrane. FT DOMAIN 1 50 Extracellular (Potential). FT TRANSMEM 51 71 1 (Potential). FT DOMAIN 72 87 Cytoplasmic (Potential). FT TRANSMEM 88 108 2 (Potential). FT DOMAIN 109 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT DOMAIN 141 159 Cytoplasmic (Potential). FT TRANSMEM 160 180 4 (Potential). FT DOMAIN 181 207 Extracellular (Potential). FT TRANSMEM 208 228 5 (Potential). FT DOMAIN 229 275 Cytoplasmic (Potential). FT TRANSMEM 276 296 6 (Potential). FT DOMAIN 297 308 Extracellular (Potential). FT TRANSMEM 309 329 7 (Potential). FT DOMAIN 330 389 Cytoplasmic (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 27 27 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT DISULFID 117 192 By similarity. SQ SEQUENCE 389 AA; 44384 MW; D24EBF372EBB6B38 CRC64; MEGLCLNLDC SELPNSSWVN SSMENQNHSS NSTRDPLKRN EEVAKVEVTV LALILFLALA GNICVLLGIY INRHKHSRMY FFMKHLSIAD LVVAIFQVLP QLIWDITFRF YAPDLVCRLV TYLQVVGMFA STYMLLLMSL DRCLAICQPL RSLHRRSDCV YVLFTWILSF LLSTPQTVIF SLTEVGNGVY DCRADFIQPW GPKAYITWIT LAVYIIPVMI LSVCYGLISY KIWQNIRLKT VCESNLRLST SRRATLSRVS SVRLISKAKI RTVKMTFIIV LAYIVCWTPF FFVQMWSVWD PNPPKEASLF IIAMLLGSLN SCCNPWIYML FTGHLFHDLL QSFLCCSARY LKTQQQGSDL SASRKSNSST FVLSRKSSSQ KSITQPSTA // ID BRB1_MOUSE STANDARD; PRT; 334 AA. AC Q61125; Q9Z1F4; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE B1 bradykinin receptor (BK-1 receptor) (B1R). GN BDKRB1 OR BDKRB. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A., AND INDUCTION. RC STRAIN=129/SvJ; RX MEDLINE=96176983; PubMed=8602848; RA Pesquero J.B., Pesquero J.L., Oliveira S.M., Roscher A.A., Metzger R., RA Ganten D., Bader M.; RT "Molecular cloning and functional characterization of a mouse RT bradykinin B1 receptor gene."; RL Biochem. Biophys. Res. Commun. 220:219-225(1996). RN [2] RP SEQUENCE FROM N.A. RA Yanagawa T., Prado G.N., Paquet J.L., Bestian S., Cousins B., RA Navarro J.; RT "Novel pharmacological selectivity of the cloned murine B1 bradykinin RT receptor."; RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in CC chronic pain and inflammation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in heart, liver and lung. CC -!- INDUCTION: By lipopolysaccharide (LPS) in heart, liver and lung CC five hours after treatment. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U47281; AAA99778.1; -. DR EMBL; U44436; AAD00029.1; -. DR PIR; JC4681; JC4681. DR MGD; MGI:88144; Bdkrb1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00425; BRADYKININR. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 41 Extracellular (Potential). FT TRANSMEM 42 62 1 (Potential). FT DOMAIN 63 80 Cytoplasmic (Potential). FT TRANSMEM 81 101 2 (Potential). FT DOMAIN 102 118 Extracellular (Potential). FT TRANSMEM 119 139 3 (Potential). FT DOMAIN 140 161 Cytoplasmic (Potential). FT TRANSMEM 162 182 4 (Potential). FT DOMAIN 183 214 Extracellular (Potential). FT TRANSMEM 215 235 5 (Potential). FT DOMAIN 236 258 Cytoplasmic (Potential). FT TRANSMEM 259 279 6 (Potential). FT DOMAIN 280 302 Extracellular (Potential). FT TRANSMEM 303 323 7 (Potential). FT DOMAIN 324 334 Cytoplasmic (Potential). FT DISULFID 117 196 By similarity. FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT CARBOHYD 192 192 N-linked (GlcNAc...) (Potential). FT CONFLICT 216 216 L -> V (in Ref. 2). FT CONFLICT 260 260 L -> P (in Ref. 2). FT CONFLICT 263 265 VAS -> SSL (in Ref. 2). FT CONFLICT 331 334 LGTL -> WELYKRCTSLKNAVLPSRKELFQLSCWN (in FT Ref. 2). SQ SEQUENCE 334 AA; 37885 MW; 77C806203AC5C6CC CRC64; MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG LLGNLLVLSF FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW AENVGNRFNW PFGSDLCRVV SGVIKANLFI SIFLVVAISQ DRYRLLVYPM TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF LLRSVKVVPD LNISACILLF PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK EASRTRCGGP KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL // ID OXYR_SHEEP STANDARD; PRT; 391 AA. AC Q28756; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE Oxytocin receptor (OT-R). GN OXTR. OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Endometrium; RX MEDLINE=96116215; PubMed=8800644; RA Riley P.R., Flint A.P.F., Abayasekara D.R.E., Stewart H.J.; RT "Structure and expression of an ovine endometrial oxytocin receptor RT cDNA."; RL J. Mol. Endocrinol. 15:195-202(1995). RN [2] RP CHARACTERIZATION. RX MEDLINE=96296280; PubMed=8691097; RA Riley P.R., Abayasekara D.R.E., Stewart H.J., Flint A.P.F.; RT "Functional characterisation of an ovine endometrial oxytocin receptor RT cDNA transiently expressed in Cos-7 cells."; RL J. Endocrinol. 149:389-396(1996). CC -!- FUNCTION: RECEPTOR FOR OXYTOCIN. THE ACTIVITY OF THIS RECEPTOR IS CC MEDIATED BY G PROTEINS WHICH ACTIVATE A PHOSPHATIDYLINOSITOL- CC CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X87986; CAA61239.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 63 1 (POTENTIAL). FT DOMAIN 64 74 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 75 97 2 (POTENTIAL). FT DOMAIN 98 113 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 114 135 3 (POTENTIAL). FT DOMAIN 136 154 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 155 175 4 (POTENTIAL). FT DOMAIN 176 202 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 203 225 5 (POTENTIAL). FT DOMAIN 226 277 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 278 296 6 (POTENTIAL). FT DOMAIN 297 311 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 312 334 7 (POTENTIAL). FT DOMAIN 335 391 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 15 15 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 26 26 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 112 187 BY SIMILARITY. SQ SEQUENCE 391 AA; 43271 MW; 6FE5D67C8B8E7E69 CRC64; MEGAFAANWS AEAVNGSAAP PGTEGNRTAG PPQRNEALAR VEVAVLSLIL FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLAVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTEAAAA EASAGAEGAA ADCAGRAALA RVSNVKLISK AKIRTVKMTF IVVLAFIVCW TPFFFKQMWS VWDADAPKEA SAFIIAMLLA SLNSCCNPWI YMLFTGHLFQ DLVQRFLCCS FRRLKGSQLG ETSVTKKIHS YTFVLSRHSS SQRSCSQPST V // ID C5AR_CANFA STANDARD; PRT; 352 AA. AC P30992; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE C5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR). GN C5R1. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93111969; PubMed=1472004; RA Perret J.J., Raspe E., Vassart G., Parmentier M.; RT "Cloning and functional expression of the canine anaphylatoxin C5a RT receptor. Evidence for high interspecies variability."; RL Biochem. J. 288:911-917(1992). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C5a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Sulfation plays a critical role in the association of C5aR CC with C5a, but no significant role in the ability of the receptor CC to transduce a signal and mobilize calcium in response to a small CC peptide agonist (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X65860; CAA46690.1; -. DR PIR; S27357; S27357. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Sulfation; KW Chemotaxis. FT DOMAIN 1 38 Extracellular (Potential). FT TRANSMEM 39 61 1 (Potential). FT DOMAIN 62 72 Cytoplasmic (Potential). FT TRANSMEM 73 95 2 (Potential). FT DOMAIN 96 111 Extracellular (Potential). FT TRANSMEM 112 133 3 (Potential). FT DOMAIN 134 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 4 (Potential). FT DOMAIN 176 202 Extracellular (Potential). FT TRANSMEM 203 228 5 (Potential). FT DOMAIN 229 244 Cytoplasmic (Potential). FT TRANSMEM 245 267 6 (Potential). FT DOMAIN 268 284 Extracellular (Potential). FT TRANSMEM 285 305 7 (Potential). FT DOMAIN 306 352 Cytoplasmic (Potential). FT DISULFID 110 189 By similarity. FT MOD_RES 11 11 Sulfotyrosine (By similarity). FT MOD_RES 14 14 Sulfotyrosine (By similarity). SQ SEQUENCE 352 AA; 39212 MW; A31F8F1F8D02F135 CRC64; MASMNFSPPE YPDYGTATLD PNIFVDESLN TPKLSVPDMI ALVIFVMVFL VGVPGNFLVV WVTGFEVRRT INAIWFLNLA VADLLSCLAL PILFSSIVQQ GYWPFGNAAC RILPSLILLN MYASILLLTT ISADRFVLVF NPIWCQNYRG PQLAWAACSV AWAVALLLTV PSFIFRGVHT EYFPFWMTCG VDYSGVGVLV ERGVAILRLL MGFLGPLVIL SICYTFLLIR TWSRKATRST KTLKVVVAVV VSFFVLWLPY QVTGMMMALF YKHSESFRRV SRLDSLCVAV AYINCCINPI IYVLAAQGFH SRFLKSLPAR LRQVLAEESV GRDSKSITLS TVDTPAQKSQ GV // ID PAR1_CRILO STANDARD; PRT; 428 AA. AC Q00991; Q60461; DT 01-APR-1993 (Rel. 25, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Proteinase activated receptor 1 precursor (PAR-1) (Thrombin receptor). GN F2R OR PAR1. OS Cricetulus longicaudatus (Long-tailed hamster) (Chinese hamster). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Cricetinae; OC Cricetulus. OX NCBI_TaxID=10030; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=91348247; PubMed=1652467; RA Rasmussen U.B., Vouret-Craviari V., Jallat S., Schlesinger Y., RA Pages G., Pavirani A., Lecocq J.P., Pouyssegur J., RA Obberghen-Schilling E.; RT "cDNA cloning and expression of a hamster alpha-thrombin receptor RT coupled to Ca2+ mobilization."; RL FEBS Lett. 288:123-128(1991). RN [2] RP SEQUENCE OF 42-428 FROM N.A. RX MEDLINE=96028007; PubMed=7488069; RA Hartmann T., Grace M.B., Buzard G.S., Ruoss S.J.; RT "Thrombin receptor polymorphism in Chinese hamster."; RL Biochem. Biophys. Res. Commun. 215:974-980(1995). CC -!- FUNCTION: High affinity receptor for activated thrombin coupled to CC G proteins that stimulate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: A proteolytic cleavage generates a new amino terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X61958; CAA43957.1; -. DR EMBL; U34047; AAA86747.1; -. DR PIR; S17148; S17148. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Blood coagulation; Polymorphism. FT SIGNAL 1 21 POTENTIAL. FT PROPEP 22 41 REMOVED FOR RECEPTOR ACTIVATION (BY FT SIMILARITY). FT CHAIN 42 428 PROTEINASE ACTIVATED RECEPTOR 1. FT DOMAIN 42 105 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 106 131 1 (POTENTIAL). FT DOMAIN 132 140 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 141 160 2 (POTENTIAL). FT DOMAIN 161 179 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 180 201 3 (POTENTIAL). FT DOMAIN 202 221 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 222 242 4 (POTENTIAL). FT DOMAIN 243 271 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 272 291 5 (POTENTIAL). FT DOMAIN 292 314 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 315 337 6 (POTENTIAL). FT DOMAIN 338 352 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 353 377 7 (POTENTIAL). FT DOMAIN 378 428 CYTOPLASMIC (POTENTIAL). FT DOMAIN 60 63 ASP/GLU-RICH (ACIDIC). FT DOMAIN 301 304 POLY-SER. FT SITE 41 42 CLEAVAGE (BY THROMBIN) (BY SIMILARITY). FT DISULFID 178 257 BY SIMILARITY. FT CARBOHYD 65 65 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 78 78 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 253 253 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 262 262 N-LINKED (GLCNAC...) (POTENTIAL). FT VARIANT 84 84 MISSING (IN AN ALLELE). FT CONFLICT 384 384 H -> T (IN REF. 1). SQ SEQUENCE 428 AA; 47602 MW; E5492AB2CD877E2F CRC64; MGPQRLLLVA AGLSLCGPLL SSRVPVRQPE SEMTDATVNP RSFFLRNPGE NTFELIPLGD EEEKNESTLP EGRAIYLNKS HSPPAPLAPF ISEDASGYLT SPWLRLFIPS VYTFVFVVSL PLNILAIAVF VLKMKVKKPA VVYMLHLAMA DVLFVSVLPL KISYYFSGSD WQFGSGMCRF ATAAFYCNMY ASIMLMTVIS IDRFLAVVYP IQSLSWRTLG RANFTCLVIW VMAIMGVVPL LLKEQTTRVP GLNITTCHDV LNETLLQGFY SYYFSAFSAV FFLVPLIIST ICYMSIIRCL SSSSVANRSK KSRALFLSAA VFCVFIVCFG PTNVLLIMHY LLLSDSPATE KAYFAYLLCV CVSSVSCCID PLIYYYASSE CQRHLYGILC CKESSDPNSY NSTGQLMPSK MDTCSSHLNN SIYKKLLA // ID NTR1_RAT STANDARD; PRT; 424 AA. AC P20789; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1991 (Rel. 17, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Neurotensin receptor type 1 (NT-R-1) (High-affinity levocabastine- DE insensitive neurotensin receptor) (NTRH). GN NTSR1. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=90297956; PubMed=1694443; RA Tanaka K., Masu M., Nakanishi S.; RT "Structure and functional expression of the cloned rat neurotensin RT receptor."; RL Neuron 4:847-854(1990). CC -!- FUNCTION: RECEPTOR FOR THE TRIDECAPEPTIDE NEUROTENSIN. IT IS CC ASSOCIATED WITH G PROTEINS THAT ACTIVATE A PHOSPHATIDYLINOSITOL- CC CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. DR PIR; JH0164; JH0164. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003985; NT1_receptor. DR InterPro; IPR003984; NT_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01479; NEUROTENSINR. DR PRINTS; PR01480; NEUROTENSN1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 64 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 65 87 1 (POTENTIAL). FT DOMAIN 88 96 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 97 121 2 (POTENTIAL). FT DOMAIN 122 143 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 144 165 3 (POTENTIAL). FT DOMAIN 166 188 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 189 210 4 (POTENTIAL). FT DOMAIN 211 235 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 236 260 5 (POTENTIAL). FT DOMAIN 261 308 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 309 330 6 (POTENTIAL). FT DOMAIN 331 348 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 349 372 7 (POTENTIAL). FT DOMAIN 373 424 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 38 38 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 42 42 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 142 225 BY SIMILARITY. FT LIPID 388 388 S-palmitoyl cysteine (Potential). SQ SEQUENCE 424 AA; 47054 MW; A9C2F7EAF8D9BCD3 CRC64; MHLNSSVPQG TPGEPDAQPF SGPQSEMEAT FLALSLSNGS GNTSESDTAG PNSDLDVNTD IYSKVLVTAI YLALFVVGTV GNSVTAFTLA RKKSLQSLQS TVHYHLGSLA LSDLLILLLA MPVELYNFIW VHHPWAFGDA GCRGYYFLRD ACTYATALNV ASLSVERYLA ICHPFKAKTL MSRSRTKKFI SAIWLASALL AIPMLFTMGL QNRSGDGTHP GGLVCTPIVD TATVKVVIQV NTFMSFLFPM LVISILNTVI ANKLTVMVHQ AAEQGRVCTV GTHNGLEHST FNMTIEPGRV QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRHRRKKRPT FSRKPNSMSS NHAFSTSATR ETLY // ID V2R_PIG STANDARD; PRT; 370 AA. AC P32307; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Vasopressin V2 receptor (Renal-type arginine vasopressin receptor) DE (Antidiuretic hormone receptor) (AVPR V2). GN AVPR2. OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Kidney; RX MEDLINE=93345481; PubMed=8393786; RA Gorbulev V., Buechner H., Akhundova A., Fahrenholz F.; RT "Molecular cloning and functional characterization of V2 [8-lysine] RT vasopressin and oxytocin receptors from a pig kidney cell line."; RL Eur. J. Biochem. 215:1-7(1993). CC -!- FUNCTION: RECEPTOR FOR ARGININE VASOPRESSIN. THE ACTIVITY OF THIS CC RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE ADENYLATE CC CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X71795; CAA50678.1; -. DR PIR; S34042; S34042. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 37 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 38 62 1 (POTENTIAL). FT DOMAIN 63 76 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 77 97 2 (POTENTIAL). FT DOMAIN 98 112 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 113 134 3 (POTENTIAL). FT DOMAIN 135 158 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 159 179 4 (POTENTIAL). FT DOMAIN 180 199 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 200 219 5 (POTENTIAL). FT DOMAIN 220 270 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 271 292 6 (POTENTIAL). FT DOMAIN 293 307 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 308 327 7 (POTENTIAL). FT DOMAIN 328 370 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 21 21 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 340 340 S-palmitoyl cysteine (By similarity). FT LIPID 341 341 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 370 AA; 40537 MW; 18079C128B689F2F CRC64; MLRATTSAVP RALSWPAAPG NGSEREPLDD RDPLLARVEL ALLSTVFVAV ALSNGLVLGA LVRRGRRGRW APMHVFIGHL CLADLAVALF QVLPQLAWDA TYRFRGPDAL CRAVKYLQMV GMYASSYMIL AMTLDRHRAI CRPMLAYRHG GGARWNRPVL VAWAFSLLLS LPQLFIFAQR DVGDGSGVLD CWASFAEPWG LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHTSLVPGPA ERAGGHRGGR RAGSPREGAR VSAAMAKTAR MTLVIVAVYV LCWAPFFLVQ LWSVWDPKAP REGPPFVLLM LLASLNSCTN PWIYASFSSS ISSELRSLLC CPRRRTPPSL RPQEESCATA SSFSARDTSS // ID MCR2_HUMAN STANDARD; PRT; 340 AA. AC Q969V1; Q9BXA8; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Melanin-concentrating hormone receptor 2 (MCH receptor 2) (MCHR-2) DE (MCH-R2) (MCH2R) (MCH-2R) (MCH2) (G protein coupled receptor 145) DE (GPRv17). GN GPR145 OR MCHR2 OR SLT. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21255282; PubMed=11355873; RA Mori M., Harada M., Terao Y., Sugo T., Watanabe T., Shimomura Y., RA Abe M., Shintani Y., Onda H., Nishimura O., Fujino M.; RT "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the RT melanin-concentrating hormone receptor."; RL Biochem. Biophys. Res. Commun. 283:1013-1018(2001). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Fetal brain; RX MEDLINE=21309932; PubMed=11404457; RA Sailer A.W., Sano H., Zeng Z., McDonald T.P., Pan J., Pong S.-S., RA Feighner S.D., Tan C.P., Fukami T., Iwaasa H., Hreniuk D.L., RA Morin N.R., Sadowski S.J., Ito M., Ito M., Bansal A., Ky B., RA Figueroa D.J., Jiang Q., Austin C.P., MacNeil D.J., Ishihara A., RA Ihara M., Kanatani A., Van der Ploeg L.H.T., Howard A.D., Liu Q.; RT "Identification and characterization of a second melanin-concentrating RT hormone receptor, MCH-2R."; RL Proc. Natl. Acad. Sci. U.S.A. 98:7564-7569(2001). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=21433976; PubMed=11459838; RA Wang S., Behan J., O'Neill K., Weig B., Fried S., Laz T., Bayne M., RA Gustafson E., Hawes B.E.; RT "Identification and pharmacological characterization of a novel human RT melanin-concentrating hormone receptor, MCH-R2."; RL J. Biol. Chem. 276:34664-34670(2001). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=21282939; PubMed=11274220; RA Hill J., Duckworth M., Murdock P., Rennie G., Sabido-David C., RA Ames R.S., Szekeres P., Wilson S., Bergsma D.J., Gloger I.S., RA Levy D.S., Chambers J.K., Muir A.I.; RT "Molecular cloning and functional characterization of MCH2, a novel RT human MCH receptor."; RL J. Biol. Chem. 276:20125-20129(2001). RN [5] RP SEQUENCE FROM N.A. RA Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M., RA Kamohara M., Saito T., Soga T., Saito Y., Oda T., Masuho Y., RA Furuichi K.; RT "Molecular characterization of a novel melanin-concentrating hormone RT receptor: evidence of its expression in lateral hypothalamus."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to G CC proteins that activate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Specifically expressed in the brain, with CC highest levels in cerebral cortex, hippocampus and amygdala. No CC expression detected in the cerebellum, thalamus or hypothalamus. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB060151; BAB55677.1; -. DR EMBL; AY029596; AAK38157.1; -. DR EMBL; AF399937; AAL05528.1; -. DR EMBL; AF347063; AAK32193.1; -. DR EMBL; AB058849; BAB87842.1; -. DR PIR; JC7695; JC7695. DR Genew; HGNC:20867; GPR145. DR MIM; 606111; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008362; MCH2_receptor. DR InterPro; IPR008361; MCH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01784; MCH2RECEPTOR. DR PRINTS; PR01783; MCHRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 39 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 40 60 1 (POTENTIAL). FT DOMAIN 61 69 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 70 90 2 (POTENTIAL). FT DOMAIN 91 104 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 105 129 3 (POTENTIAL). FT DOMAIN 130 154 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 155 175 4 (POTENTIAL). FT DOMAIN 176 200 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 201 221 5 (POTENTIAL). FT DOMAIN 222 252 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 253 273 6 (POTENTIAL). FT DOMAIN 274 288 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 289 309 7 (POTENTIAL). FT DOMAIN 310 340 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 10 10 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 17 17 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 340 AA; 38849 MW; 754A302BB951FAC6 CRC64; MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV GNILIVFTII RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTRWRTRYKT IRINLGLWAA SFILALPVWV YSKVIKFKDG VESCAFDLTS PDDVLWYTLY LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF // ID PKR2_MOUSE STANDARD; PRT; 381 AA. AC Q8K458; Q80XQ0; Q8BIR4; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Prokineticin receptor 2 (PK-R2) (G protein-coupled receptor 73-like DE 1). GN GPR73L1 OR PKR2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6; RX MEDLINE=22022134; PubMed=12024206; RA Cheng M.Y., Bullock C.M., Li C., Lee A.G., Bermak J.C., Belluzzi J., RA Weaver D.R., Leslie F.M., Zhou Q.-Y.; RT "Prokineticin 2 transmits the behavioural circadian rhythm of the RT suprachiasmatic nucleus."; RL Nature 417:405-410(2002). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, Pituitary, and Thymus; RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for prokineticin 2. Exclusively coupled to the CC G(q) subclass of heteromeric G proteins. Activation leads to CC mobilization of calcium, stimulation of phosphoinositide turnover CC and activation of p44/p42 mitogen-activated protein kinase (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in several regions of the brain, CC including paraventricular hypothalamic nucleus, dorsal medial CC hypothalamic nucleus, paratenial thalamic nuclei, paracentral CC thalamic nucleus, lateral habenular nucleus, lateral septal CC nucleus, lateral globus pallidus and amygdala. Highest expression CC seen in paraventricular thalamic nuclei and is also extensively CC expressed in the suprachiasmatic nucleus. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF487279; AAM49571.1; -. DR EMBL; AK030458; BAC26971.1; ALT_INIT. DR EMBL; AK041586; BAC30994.1; -. DR EMBL; AK080980; BAC38103.1; -. DR EMBL; BC043116; AAH43116.1; -. DR MGD; MGI:2181363; Gpr73l1. DR GO; GO:0007623; P:circadian rhythm; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 51 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 52 72 1 (POTENTIAL). FT DOMAIN 73 86 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 87 107 2 (POTENTIAL). FT DOMAIN 108 133 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 134 154 3 (POTENTIAL). FT DOMAIN 155 168 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 169 189 4 (POTENTIAL). FT DOMAIN 190 220 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 221 241 5 (POTENTIAL). FT DOMAIN 242 270 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 271 291 6 (POTENTIAL). FT DOMAIN 292 310 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 311 331 7 (POTENTIAL). FT DOMAIN 332 381 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 7 7 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 24 24 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 125 205 BY SIMILARITY. FT CONFLICT 244 244 S -> P (IN REF. 3). FT CONFLICT 375 375 V -> L (IN REF. 2; BAC26971). SQ SEQUENCE 381 AA; 43375 MW; 1981FD101324166D CRC64; MGPQNRNTSF APDLNPPQDH VSLNYSYGDY DLPLGEDEDV TKTQTFFAAK IVIGVALAGI MLVCGIGNFV FIAALARYKK LRNLTNLLIA NLAISDFLVA IVCCPFEMDY YVVRQLSWAH GHVLCASVNY LRTVSLYVST NALLAIAIDR YLAIVHPLKP RMNYQTASFL IALVWMVSIL IAVPSAYFTT ETILVIVKNQ EKIFCGQIWS VDQQLYYKSY FLFVFGLEFV GPVVTMTLCY ARISQELWFK AVPGFQTEQI RKRLRCRRKT VLLLMGILTA YVLCWAPFYG FTIVRDFFPT VVVKEKHYLT AFYVVECIAM SNSMINTICF VTVKNNTMKY FKKMLRLHWR PSHYGSKSSA DLDLKTSGVP ATEEVDCIRL K // ID GP32_HUMAN STANDARD; PRT; 356 AA. AC O75388; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Probable G protein-coupled receptor GPR32. GN GPR32. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98317543; PubMed=9653656; RA Marchese A., Nguyen T., Malik P., Xu S., Cheng R., Xie Z., RA Heng H.H.Q., George S.R., Kolakowski L.F. Jr., O'Dowd B.F.; RT "Cloning genes encoding receptors related to chemoattractant RT receptors."; RL Genomics 50:281-286(1998). CC -!- FUNCTION: ORPHAN RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF045764; AAC39801.1; -. DR Genew; HGNC:4487; GPR32. DR MIM; 603195; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Polymorphism. FT DOMAIN 1 44 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 45 67 1 (POTENTIAL). FT DOMAIN 68 78 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 79 100 2 (POTENTIAL). FT DOMAIN 101 116 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 117 137 3 (POTENTIAL). FT DOMAIN 138 156 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 157 178 4 (POTENTIAL). FT DOMAIN 179 220 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 221 241 5 (POTENTIAL). FT DOMAIN 242 257 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 258 280 6 (POTENTIAL). FT DOMAIN 281 300 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 301 320 7 (POTENTIAL). FT DOMAIN 321 356 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 30 30 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 199 199 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 114 191 POTENTIAL. FT VARIANT 327 327 F -> L (IN DBSNP:1864011). FT /FTId=VAR_011860. SQ SEQUENCE 356 AA; 40087 MW; 0E00DCF4BD7F4C3A CRC64; MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL SASIVVGVLG NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY YIVSRQWLLG EWACKLYITF VFLSYFASNC LLVFISVDRC ISVLYPVWAL NHRTVQRASW LAFGVWLLAA ALCSAHLKFR TTRKWNGCTH CYLAFNSDNE TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR AKLLREGWVH ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR GNAPRE // ID MSHR_CALJA STANDARD; PRT; 344 AA. AC Q864H7; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Callithrix jacchus (Common marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Callitrichidae; Callithrix. OX NCBI_TaxID=9483; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 292; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205120; AAP30994.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 344 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 344 AA; 37574 MW; A13AF8051C9A603C CRC64; MPMQGAQRKL LGSLNSTPTA TSNPGLAANH TGAPCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SSMYYFICCL ALSDLLVSGS NMLETAIILL LEAGTLATRA SVVQQLHNTI DVLTCSSMLC SLCFLGAIAV DRYISIFYAL RYHSIMTLPR AQRAIAAIWV ASVLSSTLFI TYYDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG IIRLHNRQLP AHKGFGLRGA ATLTILLGIF FLCWGPFFLH LTLVVFCPQH LTCNCIFKNF KVFLTLIICN TIIDPLIYAF RSQELRRTLK EVLLCSSWPG CWAEGGGDSV WPGSCVTLRG PLPP // ID MSHR_DAMDA STANDARD; PRT; 317 AA. AC P56446; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R OR MSHR. OS Dama dama (Fallow deer) (Cervus dama). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Cervidae; OC Cervinae; Cervus. OX NCBI_TaxID=30532; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20093783; PubMed=10628296; RA Klungland H., Roed K.H., Nesbo C.L., Jakobsen K.S., Vage D.I.; RT "The melanocyte-stimulating hormone receptor (MC1-R) gene as a tool RT in evolutionary studies of artiodactyles."; RL Hereditas 131:39-46(1999). CC -!- FUNCTION: Receptor for MSH (alpha, beta) and ACTH. Does not seem CC to be active with gamma-MSH. The activity of this receptor is CC mediated by G proteins which activate adenylate cyclase. Could be CC involved in spermatogenesis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y13963; CAA74297.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). SQ SEQUENCE 317 AA; 34910 MW; 3E4368D13D11F70E CRC64; MPVLGSQRRL LGSLNCTPPA TFPLTLAPNR TGPQCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SPMYYFICCL AMSDLLVSVS NVLETAVMLL LEAGALAAQA AVVQQLDNVI DVLICGSMVS SLCFLGAIAV DRYISIFYAL RYHSVVTLPR AWRIIAAIWV ASILTSLLFI TYYNHTVVLL CLVGFFIAML ALMAVLYVHM LARACQHARG IARLQKRQRP IHQGFGLKGA ATLTILLGVF FLCWGPFFLH LSLIVLCPQH PTCGCIFKNF NLFLALIICN AIVDPLIYAF RSQELRKTLQ EVLQCSW // ID MSHR_PANON STANDARD; PRT; 317 AA. AC Q865E8; Q865E7; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Panthera onca (Jaguar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Felidae; Panthera. OX NCBI_TaxID=9690; RN [1] RP SEQUENCE FROM N.A., AND VARIANT ALLELE MC1R-DELTA-15. RC STRAIN=Isolate Pon72; RX MEDLINE=22507909; PubMed=12620197; RA Eizirik E., Yuhki N., Johnson W.E., Menotti-Raymond M., Hannah S.S., RA O'Brien S.J.; RT "Molecular genetics and evolution of melanism in the cat family."; RL Curr. Biol. 13:448-453(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta) and ACTH. Does not seem CC to be active with gamma-MSH. The activity of this receptor is CC mediated by G proteins which activate adenylate cyclase. Could be CC involved in spermatogenesis (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- POLYMORPHISM: The allele MC1R-delta-15 is associated with CC melanistic coat coloration. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY237396; AAO62413.1; -. DR EMBL; AY237397; AAO62414.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate; Polymorphism. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT VARIANT 101 106 LEAGTL -> T (in allele MC1R-delta-15). SQ SEQUENCE 317 AA; 34721 MW; 293AF0431B9093C7 CRC64; MSVQGPQRRL LGSLNSTSPA APRLGLAANQ TGPRCLEVSV PDGLFLSLGL VSVVENVLVV AAIAKNRNLH SPMYYFICCL AVSDLLVSVS SVLETAVMLL LEAGTLAGRA AVVQQLDDVI DVLVCGAMVS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR AWRAISAIWV ASVLSSTLFI AYYDHTAVLL CLVSFFVAML VLMAVLYVHM LARACQHARG IARLHKRQRP VHQGLGLKGA ATLTILLGIF FLCWGPFFLH LSLMVLCPRH PICGCVFKNF NLFLTLIICN SIVDPLIYAF RSQELRKTLQ EVLLCSW // ID MSHR_FELCA STANDARD; PRT; 317 AA. AC Q865E9; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Felis silvestris catus (Cat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Felidae; Felis. OX NCBI_TaxID=9685; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate Fca273; RX MEDLINE=22507909; PubMed=12620197; RA Eizirik E., Yuhki N., Johnson W.E., Menotti-Raymond M., Hannah S.S., RA O'Brien S.J.; RT "Molecular genetics and evolution of melanism in the cat family."; RL Curr. Biol. 13:448-453(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta) and ACTH. Does not seem CC to be active with gamma-MSH. The activity of this receptor is CC mediated by G proteins which activate adenylate cyclase. Could be CC involved in spermatogenesis (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY237395; AAO62412.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). SQ SEQUENCE 317 AA; 34751 MW; 57A04CC0E2DAB442 CRC64; MSVQGPQRRL LGSLNSTSPA APRLGLAANQ TGPRCLELSV PDGLFLGLGL VSVVENVLVV AAIAKNRNLH SPMYYFICCL AVSDLLVSVS SVLETAVMLL LEAGALAGRA AVVQRLDDII DVLVCGAMVS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR AWRAISAIWV ASVLSSTLFI AYYDHTAVLL CLVSFFVAML VLMAVLYVHM LARACQHARG IARLHKRQRP VHQGLGLKGA ATLTILLGIF FLCWGPFFLH LSLMVLCPRH PICGCVFKNF NLFLTLIICN SIVDPFIYAF RSQELRKTLQ EVLLCSW // ID MSHR_MANSP STANDARD; PRT; 317 AA. AC Q864J1; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Mandrillus sphinx (Mandrill) (Papio sphinx). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Mandrillus. OX NCBI_TaxID=9561; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 1; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205106; AAP30980.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34778 MW; 2C31DC1D317929E3 CRC64; MPVQGSQRRL LGSLNSTPTA TPHLGLAANQ TGVRCLEVSV PDGLFLSLGL VSLVENVLVV TAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLETAVTLL LEAGALAARA AVVQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR ARRAVAAIWV ASVLFSTLFI AYYDHAAVLL CLVIFFLAML VLMAVLYVHM LARACQHAQG IARLHKRQRL AHQGFGLKGA ATLTILLGIF FLCWGPFFLH LTLIVLCPQH PTCSCIFKNF NLFLALIICN AIIDPLIYAF RSQELRRTLK EVLLCSW // ID MSHR_CERNE STANDARD; PRT; 317 AA. AC Q864K1; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Cercopithecus neglectus (Debrazza's monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Cercopithecus. OX NCBI_TaxID=36227; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 2; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205096; AAP30970.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34763 MW; C99B8C7A8ADEE145 CRC64; MPVQGSQRRL LGSLNSTPTA PPHLGLAANQ TGTRCLEVSI PDGLFLSLGL VSLVENVLVV TAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLETAVILL LEAGALAARA AVVQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR ARRAVAAIWV ASVLFSMLFI AYYDHAAVLL CLVVFFLAML VLMAVLYIHM LARACQHAQG IARLHKRQCP AHQGFGLKGA ATLTILLGIF FLCWGPFFLH LTLIVLCPQH PTCSCIFKNF NLFLALIICN AIIDPLIYAF RSQELRRTLK EVLLCSW // ID MSHR_COLGU STANDARD; PRT; 317 AA. AC Q864J0; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Colobus guereza (Black-and-white colobus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Colobinae; OC Colobus. OX NCBI_TaxID=33548; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 1; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205107; AAP30981.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34709 MW; 027527FB6DD430A4 CRC64; MPVQGSQRRL LGSLNSTPTA TPKLGLAANQ TGAWCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLETAVILL LEAGALAARA AVVQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR AQRVVAAIWV ASVLFSTLFI AYYDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG IAQLHKRQRP AHQGFGLKGA ATLTILLGIF FLCWGPFFLH LTLIVLCPQH PTCSCIFKNF NLFLALIICN AIIDPLIYAF RSQELRRTLK EVLLCSW // ID MSHR_MACSY STANDARD; PRT; 317 AA. AC Q864J6; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Macaca sylvanus (Barbary ape). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9546; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 1; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205101; AAP30975.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34731 MW; D2C8A533AF14463F CRC64; MPVQGSQRRL LGSLNSTPTA TPHLGLAANQ TGARCLEVSV PDGLFLSLGL VSLVENVLVV TAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLETAVTLL LEAGALAARA AVVQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR ARRAVAAIWV ASVLCSTLFI AYYDHXAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG IARLHKRQRL AHQGFGLKGA ATLTILLGIF FLCWGPFFLH LTLIVLCPQH PTCSCIFKNF NLFLALIICN AIIDPLIYAF RSQELRRTLK EVLLCSW // ID MSHR_ALOPA STANDARD; PRT; 317 AA. AC Q864G2; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Alouatta palliata (Mantled howler monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Alouattinae; OC Alouatta. OX NCBI_TaxID=30589; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 1; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205135; AAP31009.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34670 MW; D5414E350E2435DE CRC64; MPMQGAQRRL LGSLNSTPTA TPNLGLAANH TGAPCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLETAVILL LEAGALATRA SVVQQLQNTI DVLTCSSMLC SLCFLGAIAV DRYVSIFYAL RYHSIVTLPR ARRAIAAIWV ASVLSSTLFI AYCDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG ITRLHKRQLP AHQGFGLRGA ATLTILLGIF FLCWGPFFLH LMLVVLCPQH LTCSCIFKNF KVFLTLIICN TIIDPLIYAF RSQELCRTLK EVLLCSW // ID MSHR_HYLLA STANDARD; PRT; 317 AA. AC Q864K8; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Hylobates lar (Common gibbon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hylobatidae; Hylobates. OX NCBI_TaxID=9580; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 1; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205089; AAP30963.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34823 MW; 1BDCC156B09BB18D CRC64; MAVQGFQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI PDGLFLSLGL VSLVENVLVV ATIAKNRNLH SPTYCFICCL ALSDLLVSGG NVLETVVILL LEASALAARA AVVQPLDNVI DVITCSSMVS SLCFLGAIAM DRYVSIFYAL RYHSIVTLPR ARQAIAAIWV ASVLFSTLFI AYYDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG IARLHKRQRP LHQGFGLKGA VTLTILLGIF FLCWGPFFLH LTLIVLCPQH PTCSCIFKNF NLFLTLIICN AIIDPLIYAF RRQELRRTLK EGLTCSW // ID MSHR_PANTR STANDARD; PRT; 317 AA. AC Q9TUK4; Q864L1; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP SEQUENCE FROM N.A. RA Rees J.L., Harding R.M., Healy E., Jackson I.J., Ray A.J., Ellis N.S., RA Flanagan N., Todd C., Dixon C., Matthews J.N., Sajantila A., RA Birch-Machin M.A.; RT "Chimpanzee melanocortin 1 sequence."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 3; RX MEDLINE=22572539; PubMed=12687585; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AJ245705; CAB53398.1; -. DR EMBL; AY205086; AAP30960.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). SQ SEQUENCE 317 AA; 34699 MW; 6615D2146E1D247F CRC64; MAVQGSQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI PDGLFLSLGL VSLVENMLVV ATIAKNRNLH SPMYCFICCL ALSDLLVSGS NVLETAVILL LEAGALVARA AVLQQVDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR ARRAIAAIWV ASVLFSTLFI AYCDHTAVLL CLVVFFLAVL VLMAVLYVHM LARACQHAQG IARLHKRQRP VHQGFGLKGA VTLTILLGIF FLCWGPFFLH LTLIVLCPEH PTCGCIFKNF NLFLALIICN AIIDPLIYAF HSQELRRTLK EVLTCSW // ID MSHR_HYLCO STANDARD; PRT; 317 AA. AC Q864K6; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Hylobates concolor (Crested gibbon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hylobatidae; Hylobates. OX NCBI_TaxID=29089; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 1; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205091; AAP30965.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34775 MW; DABEEF166B477468 CRC64; MAVQGFQRRL LGSLNSTPTA IPQLRLAANQ TGARCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SPTYCFICCL ALSDLLVSGG NVLETVVILL LEASALAARA AVVQQLDNVI DVITCSSMVS SLCFLGAIAV DRHVSIFYAL RYHSIVTLPR ARQAIAAIWV ASVLFSALFI AYCDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG IAQLHKRQRP LHQGFGLKGA VTLSILLGIF FLCWGPFFLH LTLIVLCPQH PTCSCIFKNF NLFLTLIICN AIIDPLIYAF RRQELRRTLK EVLTCSW // ID MSHR_ALOSA STANDARD; PRT; 317 AA. AC Q864G4; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Alouatta sara (Bolivian red howler monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Alouattinae; OC Alouatta. OX NCBI_TaxID=121123; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 449; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205133; AAP31007.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34686 MW; BA7E14AFEC7EA971 CRC64; MPMQGAQRRL LGSLNSTPTA TPNLGLAANH TGAPCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLEMAVILL LEAGALATRA SVVQQLQNTI DVLTCSSMLC SLCFLGAIAV DRYVSIFYAL RYHSIVTLPR ARRAIAAIWV ASVLSSTLFI AYCDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG ITRLHKRQLP AHQGFGLRGA ATLTILLGIF FVCWGPFFLH LMLVVLCPQH LTCSCIFKNF KVFLTLIICN TIIDPLIYAF RSQELCRTLK EVLLCSW // ID MSHR_ATEPA STANDARD; PRT; 317 AA. AC Q864G7; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Ateles paniscus (Black spider monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Atelinae; Ateles. OX NCBI_TaxID=9510; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 3; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205130; AAP31004.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34719 MW; 5481D6A1B9085D43 CRC64; MPMQGAQKRL LGSLNSTPTA TPNLGLAANH TGAPCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SPMYCFICCL ALSDLLVSSS NMLETAVILL LEAGALATRA SVVQQLQNTI DVLTCSSMLC SLCFLGAIAV DRHVSIFYAL RYHSIMTLAR ARRAIAAIWV ASVLSSTLFI AYCDHAXVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG ITRLHQRQPP AHQGFGFRGA ATLTILLGIF FLCWGPFFLH LTLVVLCPQH LTCSCIFKNF KVFLTLIICS TIIDPLIYAF RSQELRRTLK ELLLCSW // ID MC4R_MOUSE STANDARD; PRT; 332 AA. AC P56450; Q9EQM7; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocortin-4 receptor (MC4-R). GN MC4R. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=129/Sv; RA Dumont L.M., Wu C.S., Mountjoy K.G.; RT "Characterization of the melanocortin-4 receptor gene."; RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 112-295 FROM N.A. RC STRAIN=ICR; TISSUE=Anterior pituitary; RA Morooka Y., Oomizu S., Takeuchi S., Takahashi S.; RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor specific to the heptapeptide core common to CC adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This CC receptor is mediated by G proteins that stimulate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF201662; AAG35602.1; -. DR EMBL; AB009664; BAA24015.1; -. DR MGD; MGI:99457; Mc4r. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0007631; P:feeding behavior; IMP. DR GO; GO:0019222; P:regulation of metabolism; IMP. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000155; Mcort_receptor4. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR001908; Mlncort_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00535; MELNOCORTINR. DR PRINTS; PR01062; MELNOCORTN4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 43 Extracellular (Potential). FT TRANSMEM 44 69 1 (Potential). FT DOMAIN 70 81 Cytoplasmic (Potential). FT TRANSMEM 82 106 2 (Potential). FT DOMAIN 107 123 Extracellular (Potential). FT TRANSMEM 124 145 3 (Potential). FT DOMAIN 146 165 Cytoplasmic (Potential). FT TRANSMEM 166 186 4 (Potential). FT DOMAIN 187 191 Extracellular (Potential). FT TRANSMEM 192 215 5 (Potential). FT DOMAIN 216 248 Cytoplasmic (Potential). FT TRANSMEM 249 271 6 (Potential). FT DOMAIN 272 280 Extracellular (Potential). FT TRANSMEM 281 304 7 (Potential). FT DOMAIN 305 332 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT CARBOHYD 108 108 N-linked (GlcNAc...) (Potential). FT LIPID 318 318 S-palmitoyl cysteine (Potential). FT CONFLICT 291 291 I -> M (in Ref. 2). SQ SEQUENCE 332 AA; 36988 MW; 571708415BD424D3 CRC64; MNSTHHHGMY TSLHLWNRSS YGLHSNASES LGKGHPDGGC YEQLFVSPEV FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT IFYALQYHNI MTVRRVGIII SCIWAACTVS GVLFIIYSDS SAVIICLISM FFTMLVLMAS LYVHMFLMAR LHIKRIAVLP GTGTIRQGTN MKGAITLTIL IGVFVVCWAP FFLHLLFYIS CPQNPYCVCF MSHFNLYLIL IMCNAVIDPL IYALRSQELR KTFKEIICFY PLGGICELSS RY // ID MC4R_RAT STANDARD; PRT; 332 AA. AC P70596; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocortin-4 receptor (MC4-R). GN MC4R. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=96387362; PubMed=8794897; RA Alvaro J.D., Tatro J.B., Quillan J.M., Fogliano M., Eisenhard M., RA Lerner M.R., Nestler E.J., Duman R.S.; RT "Morphine down-regulates melanocortin-4 receptor expression in brain RT regions that mediate opiate addiction."; RL Mol. Pharmacol. 50:583-591(1996). CC -!- FUNCTION: Receptor specific to the heptapeptide core common to CC adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This CC receptor is mediated by G proteins that stimulate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain, enriched in the striatum, nucleus CC accumbens, and periaque-ductal gray. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U67863; AAB36517.1; -. DR RGD; 3057; Mc4r. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00535; MELNOCORTINR. DR PRINTS; PR01062; MELNOCORTN4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 43 Extracellular (Potential). FT TRANSMEM 44 69 1 (Potential). FT DOMAIN 70 81 Cytoplasmic (Potential). FT TRANSMEM 82 106 2 (Potential). FT DOMAIN 107 123 Extracellular (Potential). FT TRANSMEM 124 145 3 (Potential). FT DOMAIN 146 165 Cytoplasmic (Potential). FT TRANSMEM 166 186 4 (Potential). FT DOMAIN 187 191 Extracellular (Potential). FT TRANSMEM 192 215 5 (Potential). FT DOMAIN 216 248 Cytoplasmic (Potential). FT TRANSMEM 249 271 6 (Potential). FT DOMAIN 272 280 Extracellular (Potential). FT TRANSMEM 281 304 7 (Potential). FT DOMAIN 305 332 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT LIPID 318 318 S-palmitoyl cysteine (Potential). SQ SEQUENCE 332 AA; 36886 MW; E0E9BAC7E7D168E6 CRC64; MNSTHHHGMY TSLHLWNRSS HGLHGNASES LGKGHSDGGC YEQLFVSPEV FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT IFYALQYHNI MTVRRVGIII SCIWAACTVS GVLFIIYSDS SAVIICLITM FFTMLVLMAS LYVHMFLMAR LHIKRIAVLP GTGTIRQGAN MKGAITLTIL IGVFVVCWAP FFLHLLFYIS CPQNPYCVCF MSHFNLYLIL IMCNAVIDPL IYALRSQELR KTFKEIICFY PLGGICELPG RY // ID TSHR_CANFA STANDARD; PRT; 764 AA. AC P14763; DT 01-APR-1990 (Rel. 14, Created) DT 01-APR-1990 (Rel. 14, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Thyrotropin receptor precursor (TSH-R) (Thyroid stimulating hormone DE receptor). GN TSHR. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Thyroid; RX MEDLINE=90098886; PubMed=2602159; RA Parmentier M., Libert F., Maenhaut C., Lefort A., Gerard C., RA Perret J., van Sande J., Dumont J.E., Vassart G.; RT "Nucleotide sequence of the dog thyrotropin receptor cDNA."; RL Nucleic Acids Res. 17:10493-10493(1989). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Thyroid; RX MEDLINE=90084524; PubMed=2556796; RA Parmentier M., Libert F., Maenhaut C., Lefort A., Gerard C., RA Perret J., van Sande J., Dumont J.E., Vassart G.; RT "Molecular cloning of the thyrotropin receptor."; RL Science 246:1620-1622(1989). CC -!- FUNCTION: Receptor for thyrothropin. Plays a central role in CC controlling thyroid cell metabolism. The activity of this receptor CC is mediated by G proteins which activate adenylate cyclase. Also CC acts as a receptor for thyrostimulin (GPA2+GPB5). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Long; CC IsoId=P14763-1; Sequence=Displayed; CC Name=Short; CC IsoId=P14763-2; Sequence=VSP_001980; CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC FSH/LSH/TSH subfamily. CC -!- SIMILARITY: Contains 4 leucine-rich (LRR) repeats. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X17146; CAA35026.1; -. DR EMBL; X17147; CAA35027.1; -. DR EMBL; M29957; AAA30901.1; -. DR EMBL; M90047; AAA30902.1; -. DR PIR; A40077; A40077. DR HSSP; P16473; 1XUM. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001611; LRR. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF00560; LRR; 3. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Phosphorylation; Repeat; Leucine-rich repeat; Alternative splicing. FT SIGNAL 1 20 FT CHAIN 21 764 THYROTROPIN RECEPTOR. FT DOMAIN 21 413 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 414 441 1 (POTENTIAL). FT DOMAIN 442 450 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 451 473 2 (POTENTIAL). FT DOMAIN 474 494 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 495 517 3 (POTENTIAL). FT DOMAIN 518 537 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 538 560 4 (POTENTIAL). FT DOMAIN 561 580 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 581 602 5 (POTENTIAL). FT DOMAIN 603 625 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 626 649 6 (POTENTIAL). FT DOMAIN 650 660 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 661 682 7 (POTENTIAL). FT DOMAIN 683 764 CYTOPLASMIC (POTENTIAL). FT REPEAT 51 74 LRR 1. FT REPEAT 150 174 LRR 2. FT REPEAT 176 199 LRR 3. FT REPEAT 201 223 LRR 4. FT DISULFID 494 569 BY SIMILARITY. FT CARBOHYD 77 77 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 99 99 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 177 177 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 198 198 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 302 302 N-LINKED (GLCNAC...) (POTENTIAL). FT VARSPLIC 81 105 Missing (in isoform Short). FT /FTId=VSP_001980. SQ SEQUENCE 764 AA; 86483 MW; 49F03B3DBCB65512 CRC64; MRPPPLLHLA LLLALPRSLG GKGCPSPPCE CHQEDDFRVT CKDIHRIPTL PPSTQTLKFI ETQLKTIPSR AFSNLPNISR IYLSIDATLQ RLESHSFYNL SKMTHIEIRN TRSLTSIDPD ALKELPLLKF LGIFNTGLGV FPDVTKVYST DVFFILEITD NPYMASIPAN AFQGLCNETL TLKLYNNGFT SIQGHAFNGT KLDAVYLNKN KYLSAIDKDA FGGVYSGPTL LDVSYTSVTA LPSKGLEHLK ELIARNTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM CNESSIRSLR QRKSVNTLNG PFDQEYEEYL GDSHAGYKDN SQFQDTDSNS HYYVFFEEQE DEILGFGQEL KNPQEETLQA FDSHYDYTVC GGNEDMVCTP KSDEFNPCED IMGYKFLRIV VWFVSLLALL GNVFVLIVLL TSHYKLTVPR FLMCNLAFAD FCMGMYLLLI ASVDLYTHSE YYNHAIDWQT GPGCNTAGFF TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHAYA IMVGGWVCCF LLALLPLVGI SSYAKVSICL PMDTETPLAL AYIILVLLLN IVAFIIVCSC YVKIYITVRN PQYNPGDKDT KIAKRMAVLI FTDFMCMAPI SFYALSALMN KPLITVTNSK ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGICK RQAQAYRGQR VSPKNSAGIQ IQKVTRDMRQ SLPNMQDEYE LLENSHLTPN KQGQISKEYN QTVL // ID FSHR_HUMAN STANDARD; PRT; 695 AA. AC P23945; Q16225; DT 01-MAR-1992 (Rel. 21, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Follicle stimulating hormone receptor precursor (FSH-R) (Follitropin DE receptor). GN FSHR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A., AND VARIANTS ALA-307 AND SER-680. RC TISSUE=Ovary; RX MEDLINE=91222171; PubMed=1709010; RA Minegish T., Nakamura K., Takakura Y., Ibuki Y., Igarashi M.; RT "Cloning and sequencing of human FSH receptor cDNA."; RL Biochem. Biophys. Res. Commun. 175:1125-1130(1991). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Testis; RX MEDLINE=93246012; PubMed=1301382; RA Kelton C.A., Cheng S.V., Nugent N.P., Schweickhardt R.L., RA Rosenthal J.L., Overton S.A., Wands G.D., Kuzeja J.B., Luchette C.A., RA Chappel S.C.; RT "The cloning of the human follicle stimulating hormone receptor and RT its expression in COS-7, CHO, and Y-1 cells."; RL Mol. Cell. Endocrinol. 89:141-151(1992). RN [3] RP SEQUENCE FROM N.A. RX PubMed=1322283; RA Tilly J.L., Aihara T., Nishimori K., Jia X.-C., Billig H., RA Kowalski K.I., Perlas E.A., Hsueh A.J.; RT "Expression of recombinant human follicle-stimulating hormone RT receptor: species-specific ligand binding, signal transduction, and RT identification of multiple ovarian messenger ribonucleic acid RT transcripts."; RL Endocrinology 131:799-806(1992). RN [4] RP SEQUENCE OF 1-342 FROM N.A. RC TISSUE=Testis; RX MEDLINE=93075197; PubMed=1359889; RA Gromoll J., Gudermann T., Nieschlag E.; RT "Molecular cloning of a truncated isoform of the human follicle RT stimulating hormone receptor."; RL Biochem. Biophys. Res. Commun. 188:1077-1083(1992). RN [5] RP SEQUENCE OF 1-51 FROM N.A. RX MEDLINE=95011044; PubMed=7926278; RA Gromoll J., Dankbar B., Gudermann T.; RT "Characterization of the 5' flanking region of the human follicle- RT stimulating hormone receptor gene."; RL Mol. Cell. Endocrinol. 102:93-102(1994). RN [6] RP SEQUENCE OF 286-695 FROM N.A., AND VARIANT SER-680. RX MEDLINE=95000244; PubMed=7916967; RA Gromoll J., Ried T., Holtgreve-Grez H., Nieschlag E., Gudermann T.; RT "Localization of the human FSH receptor to chromosome 2p21 using a RT genomic probe comprising exon 10."; RL J. Mol. Endocrinol. 12:265-271(1994). RN [7] RP 3D-STRUCTURE MODELING OF 49-228. RX MEDLINE=96363672; PubMed=8747461; RA Jiang X., Dreano M., Buckler D.R., Cheng S., Ythier A., Wu H., RA Hendrickson W.A., el Tayar N.; RT "Structural predictions for the ligand-binding region of glycoprotein RT hormone receptors and the nature of hormone-receptor interactions."; RL Structure 3:1341-1353(1995). RN [8] RP VARIANT ODG1 VAL-189. RX MEDLINE=96016091; PubMed=7553856; RA Aittomaeki K., Lucena J.L.D., Pakarinen P., Sistonen P., RA Tapanainen J., Gromoll J., Kaskikari R., Sankila E.-M., RA Lehvaslaiho H., Engel A.R., Nieschlag E., Huhtaniemi I., RA de la Chapelle A.; RT "Mutation in the follicle-stimulating hormone receptor gene causes RT hereditary hypergonadotropic ovarian failure."; RL Cell 82:959-968(1995). RN [9] RP VARIANT OVARIAN SEX CORD TUMOR SER-591. RX MEDLINE=97255220; PubMed=9100567; RA Kotlar T.J., Young R.H., Albanese C., Crowley W.F. Jr., Scully R.E., RA Jameson J.L.; RT "A mutation in the follicle-stimulating hormone receptor occurs RT frequently in human ovarian sex cord tumors."; RL J. Clin. Endocrinol. Metab. 82:1020-1026(1997). RN [10] RP VARIANT ODG1 VAL-189. RX PubMed=9851774; RA Jiang M., Aittomaeki K., Nilsson C., Pakarinen P., Iitia A., RA Torresani T., Simonsen H., Goh V., Pettersson K., de la Chapelle A., RA Huhtaniemi I.; RT "The frequency of an inactivating point mutation (566C-->T) of the RT human follicle-stimulating hormone receptor gene in four populations RT using allele-specific hybridization and time-resolved fluorometry."; RL J. Clin. Endocrinol. Metab. 83:4338-4343(1998). RN [11] RP VARIANTS ODG1 THR-160 AND CYS-573. RX MEDLINE=98443225; PubMed=9769327; RA Beau I., Touraine P., Meduri G., Gougeon A., Desroches A., RA Matuchansky C., Milgrom E., Kuttenn F., Misrahi M.; RT "A novel phenotype related to partial loss of function mutations of RT the follicle stimulating hormone receptor."; RL J. Clin. Invest. 102:1352-1359(1998). RN [12] RP VARIANTS ALA-307; ARG-524 AND SER-680. RX MEDLINE=99318093; PubMed=10391209; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [13] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). RN [14] RP VARIANTS ALA-307 AND SER-680. RX MEDLINE=22054685; PubMed=12059813; RA Asatiani K., Gromoll J., Eckardstein S.V., Zitzmann M., Nieschlag E., RA Simoni M.; RT "Distribution and function of FSH receptor genetic variants in normal RT men."; RL Andrologia 34:172-176(2002). RN [15] RP VARIANT ODG1 THR-418. RX MEDLINE=21886439; PubMed=11889179; RA Doherty E., Pakarinen P., Tiitinen A., Kiilavuori A., Huhtaniemi I., RA Forrest S., Aittomaeki K.; RT "A novel mutation in the FSH receptor inhibiting signal transduction RT and causing primary ovarian failure."; RL J. Clin. Endocrinol. Metab. 87:1151-1155(2002). RN [16] RP VARIANT OHSS ILE-449. RX MEDLINE=22812036; PubMed=12930927; RA Vasseur C., Rodien P., Beau I., Desroches A., Gerard C., RA de Poncheville L., Chaplot S., Savagner F., Croue A., Mathieu E., RA Lahlou N., Descamps P., Misrahi M.; RT "A chorionic gonadotropin-sensitive mutation in the RT follicle-stimulating hormone receptor as a cause of familial RT gestational spontaneous ovarian hyperstimulation syndrome."; RL N. Engl. J. Med. 349:753-759(2003). RN [17] RP VARIANT OHSS ASN-567. RX MEDLINE=22812037; PubMed=12930928; RA Smits G., Olatunbosun O., Delbaere A., Pierson R., Vassart G., RA Costagliola S.; RT "Ovarian hyperstimulation syndrome due to a mutation in the RT follicle-stimulating hormone receptor."; RL N. Engl. J. Med. 349:760-766(2003). CC -!- FUNCTION: Receptor for follicle stimulating hormone. The activity CC of this receptor is mediated by G proteins which activate CC adenylate cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Long; CC IsoId=P23945-1; Sequence=Displayed; CC Name=Short; CC IsoId=P23945-2; Sequence=VSP_001953, VSP_001954; CC -!- TISSUE SPECIFICITY: Sertoli cells and ovarian granulosa cells. CC -!- DISEASE: Defects in FSHR are a cause of ovarian dysgenesis 1 CC (ODG1) [MIM:233300]; also known as premature ovarian failure or CC gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or CC hereditary hypergonadotropic ovarian failure or hypergonadotropic CC ovarian dysgenesis with normal karyotype. ODG1 is an autosomal CC recessive disease characterized by primary amenorrhea, variable CC development of secondary sex characteristics, and high serum CC levels of follicle stimulating hormone (FSH) and luteinizing CC hormone (LH). CC -!- DISEASE: Defects in FSHR are a cause of ovarian hyperstimulation CC syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs CC either spontaneously or most often as an iatrogenic complication CC of ovarian stimulation treatments for in vitro fertilization. The CC clinical manifestations vary from abdominal distention and CC discomfort to potentially life-threatening, massive ovarian CC enlargement and capillary leak with fluid sequestration. CC Pathologic features of this syndrome include the presence of CC multiple serous and hemorrhagic follicular cysts lined by CC luteinized cells, a condition called hyperreactio luteinalis. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC FSH/LSH/TSH subfamily. CC -!- SIMILARITY: Contains 5 leucine-rich (LRR) repeats. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M65085; AAA52477.1; -. DR EMBL; S59900; AAB26480.1; -. DR EMBL; M95489; AAA52478.1; -. DR EMBL; X68044; CAA48179.1; -. DR EMBL; S73199; AAB32071.1; -. DR EMBL; S73526; AAB32225.1; -. DR PIR; I57661; QRHUFT. DR PDB; 1XUN; 15-MAY-97. DR Genew; HGNC:3969; FSHR. DR MIM; 136435; -. DR MIM; 233300; -. DR MIM; 608115; -. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004963; F:follicle stimulating hormone receptor activity; TAS. DR GO; GO:0007292; P:female gamete generation; TAS. DR GO; GO:0008585; P:female gonad development; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0007283; P:spermatogenesis; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001611; LRR. DR InterPro; IPR000372; LRR_Nterm. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF00560; LRR; 5. DR Pfam; PF01462; LRRNT; 1. DR PRINTS; PR01143; FSHRECEPTOR. DR PRINTS; PR00373; GLYCHORMONER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Phosphorylation; Repeat; Leucine-rich repeat; Alternative splicing; KW 3D-structure; Polymorphism; Disease mutation. FT SIGNAL 1 17 Potential. FT CHAIN 18 695 Follicle stimulating hormone receptor. FT DOMAIN 18 366 Extracellular (Potential). FT TRANSMEM 367 387 1 (Potential). FT DOMAIN 388 398 Cytoplasmic (Potential). FT TRANSMEM 399 421 2 (Potential). FT DOMAIN 422 443 Extracellular (Potential). FT TRANSMEM 444 465 3 (Potential). FT DOMAIN 466 485 Cytoplasmic (Potential). FT TRANSMEM 486 508 4 (Potential). FT DOMAIN 509 528 Extracellular (Potential). FT TRANSMEM 529 550 5 (Potential). FT DOMAIN 551 573 Cytoplasmic (Potential). FT TRANSMEM 574 597 6 (Potential). FT DOMAIN 598 608 Extracellular (Potential). FT TRANSMEM 609 630 7 (Potential). FT DOMAIN 631 695 Cytoplasmic (Potential). FT REPEAT 69 93 LRR 1. FT REPEAT 119 143 LRR 2. FT REPEAT 170 192 LRR 3. FT REPEAT 193 216 LRR 4. FT REPEAT 218 240 LRR 5. FT DISULFID 442 517 By similarity. FT CARBOHYD 191 191 N-linked (GlcNAc...) (Potential). FT CARBOHYD 199 199 N-linked (GlcNAc...) (Potential). FT CARBOHYD 293 293 N-linked (GlcNAc...) (Potential). FT CARBOHYD 318 318 N-linked (GlcNAc...) (Potential). FT VARSPLIC 224 285 Missing (in isoform Short). FT /FTId=VSP_001953. FT VARSPLIC 342 695 Missing (in isoform Short). FT /FTId=VSP_001954. FT VARIANT 160 160 I -> T (in ODG1; impairs cell surface FT expression). FT /FTId=VAR_018045. FT VARIANT 189 189 A -> V (in ODG1; very frequent in the FT Finnish population). FT /FTId=VAR_018046. FT VARIANT 307 307 T -> A (in dbSNP:6165). FT /FTId=VAR_013903. FT VARIANT 418 418 I -> T (in ODG1). FT /FTId=VAR_018047. FT VARIANT 449 449 T -> I (in OHSS). FT /FTId=VAR_017244. FT VARIANT 524 524 S -> R (in dbSNP:6167). FT /FTId=VAR_013904. FT VARIANT 567 567 D -> N (in OHSS). FT /FTId=VAR_017245. FT VARIANT 573 573 R -> C (in ODG1; alters signal FT transduction of the receptor). FT /FTId=VAR_018048. FT VARIANT 591 591 F -> S (in ovarian sex cord tumor; loss FT of function). FT /FTId=VAR_018049. FT VARIANT 680 680 N -> S (in dbSNP:6166). FT /FTId=VAR_013905. FT CONFLICT 13 13 S -> R (in Ref. 4). FT CONFLICT 112 112 N -> T (in Ref. 1). FT CONFLICT 197 198 EL -> AV (in Ref. 1). FT CONFLICT 295 295 S -> P (in Ref. 4). FT STRAND 50 52 FT TURN 54 55 FT TURN 59 67 FT STRAND 74 76 FT TURN 78 79 FT TURN 91 93 FT STRAND 99 101 FT TURN 108 110 FT HELIX 113 116 FT TURN 117 117 FT STRAND 124 126 FT HELIX 135 139 FT STRAND 148 150 FT TURN 152 153 FT TURN 155 159 FT HELIX 163 165 FT TURN 166 166 FT STRAND 174 176 FT TURN 178 179 FT TURN 185 191 FT STRAND 197 199 FT TURN 204 208 FT HELIX 212 214 FT TURN 215 216 FT STRAND 222 224 FT TURN 226 227 SQ SEQUENCE 695 AA; 78294 MW; 723B8E71F76D2CD5 CRC64; MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE VDYMTQTRGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN // ID FSHR_MACFA STANDARD; PRT; 695 AA. AC P32212; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Follicle stimulating hormone receptor precursor (FSH-R) (Follitropin DE receptor). GN FSHR. OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Testis; RX MEDLINE=94071854; PubMed=7504463; RA Gromoll J., Dankbar B., Sharma R.S., Nieschlag E.; RT "Molecular cloning of the testicular follicle stimulating hormone RT receptor of the non human primate Macaca fascicularis and RT identification of multiple transcripts in the testis."; RL Biochem. Biophys. Res. Commun. 196:1066-1072(1993). CC -!- FUNCTION: RECEPTOR FOR FOLLICLE STIMULATING HORMONE. THE ACTIVITY CC OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE CC ADENYLATE CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC FSH/LSH/TSH SUBFAMILY. CC -!- SIMILARITY: Contains 6 leucine-rich (LRR) repeats. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X74454; CAA52463.1; -. DR PIR; S36452; S36452. DR PIR; JN0898; JN0898. DR HSSP; P23945; 1XUN. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001611; LRR. DR InterPro; IPR000372; LRR_Nterm. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF00560; LRR; 3. DR Pfam; PF01462; LRRNT; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM00013; LRRNT; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Phosphorylation; Repeat; Leucine-rich repeat. FT SIGNAL 1 17 POTENTIAL. FT CHAIN 18 695 FOLLICLE STIMULATING HORMONE RECEPTOR. FT DOMAIN 18 366 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 367 387 1 (POTENTIAL). FT DOMAIN 388 398 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 399 421 2 (POTENTIAL). FT DOMAIN 422 443 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 444 465 3 (POTENTIAL). FT DOMAIN 466 485 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 486 508 4 (POTENTIAL). FT DOMAIN 509 528 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 529 550 5 (POTENTIAL). FT DOMAIN 551 573 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 574 597 6 (POTENTIAL). FT DOMAIN 598 608 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 609 630 7 (POTENTIAL). FT DOMAIN 631 695 CYTOPLASMIC (POTENTIAL). FT REPEAT 44 68 LRR 1. FT REPEAT 69 93 LRR 2. FT REPEAT 119 143 LRR 3. FT REPEAT 170 192 LRR 4. FT REPEAT 193 216 LRR 5. FT REPEAT 218 240 LRR 6. FT DISULFID 442 517 BY SIMILARITY. FT CARBOHYD 191 191 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 199 199 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 293 293 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 318 318 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 695 AA; 78343 MW; 0D60A233729B5250 CRC64; MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVHTKLRV IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP NLRYLLISNT GIKHLPDVHK IHSFQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN LKKLRARSTY NLKKLPSLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE VDYMTQTRGQ RSSLAEDNES SYSRGFDMTY AEFDYDLCNE VVDVTCSPKP DAFNPCEDIL GYNILRVLIW FISILAITGN IIVLVTLTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK VHVRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL AFVVICGCYT HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP LITVSKAKIL LVLFYPINSC ANPFLYAIFT KNFRRDFFIL LSKFGCYEMQ AQIYRTETSS TAHNSHPRNG HCSSAHRVTN GSSYILVPLS HLAQN // ID FSHR_RAT STANDARD; PRT; 692 AA. AC P20395; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1991 (Rel. 17, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Follicle stimulating hormone receptor precursor (FSH-R) (Follitropin DE receptor). GN FSHR. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Sertoli cells; RX MEDLINE=91125358; PubMed=2126341; RA Sprengel R., Braun T., Nikolics K., Segaloff D.L., Seeburg P.H.; RT "The testicular receptor for follicle stimulating hormone: structure RT and functional expression of cloned cDNA."; RL Mol. Endocrinol. 4:525-530(1990). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=92149579; PubMed=1738373; RA Heckert L.L., Daley I.J., Griswold M.D.; RT "Structural organization of the follicle-stimulating hormone receptor RT gene."; RL Mol. Endocrinol. 6:70-80(1992). CC -!- FUNCTION: RECEPTOR FOR FOLLICLE STIMULATING HORMONE. THE ACTIVITY CC OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE CC ADENYLATE CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: SERTOLI CELLS AND OVARIAN GRANULOSA CELLS. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC FSH/LSH/TSH SUBFAMILY. CC -!- SIMILARITY: Contains 6 leucine-rich (LRR) repeats. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L02842; AAA41175.1; -. DR PIR; A34548; A34548. DR PIR; A41729; A41729. DR HSSP; P23945; 1XUN. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001611; LRR. DR InterPro; IPR000372; LRR_Nterm. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF00560; LRR; 3. DR Pfam; PF01462; LRRNT; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM00013; LRRNT; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Phosphorylation; Repeat; Leucine-rich repeat. FT SIGNAL 1 17 POTENTIAL. FT CHAIN 18 692 FOLLICLE STIMULATING HORMONE RECEPTOR. FT DOMAIN 18 365 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 366 386 1 (POTENTIAL). FT DOMAIN 387 397 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 398 420 2 (POTENTIAL). FT DOMAIN 421 442 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 443 464 3 (POTENTIAL). FT DOMAIN 465 484 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 485 507 4 (POTENTIAL). FT DOMAIN 508 527 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 528 549 5 (POTENTIAL). FT DOMAIN 550 572 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 573 596 6 (POTENTIAL). FT DOMAIN 597 607 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 608 629 7 (POTENTIAL). FT DOMAIN 630 692 CYTOPLASMIC (POTENTIAL). FT REPEAT 44 68 LRR 1. FT REPEAT 69 93 LRR 2. FT REPEAT 119 143 LRR 3. FT REPEAT 170 192 LRR 4. FT REPEAT 193 216 LRR 5. FT REPEAT 218 240 LRR 6. FT DISULFID 441 516 BY SIMILARITY. FT CARBOHYD 191 191 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 199 199 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 293 293 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 692 AA; 77681 MW; 267EA78C7CFD8EC6 CRC64; MALLLVSLLA FLGTGSGCHH WLCHCSNRVF LCQDSKVTEI PTDLPRNAIE LRFVLTKLRV IPKGSFAGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP SLRYLLISNT GIKHLPAVHK IQSLQKVLLD IQDNINIHIV ARNSFMGLSF ESVILWLSKN GIEEIHNCAF NGTQLDELNL SDNNNLEELP NDVFQGASGP VILDISRTKV HSLPNHGLEN LKKLRARSTY RLKKLPNLDK FVTLMEASLT YPSHCCAFAN LKRQISELHP ICNKSILRQD IDDMTQIGDQ RVSLIDDEPS YGKGSDMMYN EFDYDLCNEV VDVTCSPKPD AFNPCEDIMG YNILRVLIWF ISILAITGNT TVLVVLTTSQ YKLTVPRFLM CNLAFADLCI GIYLLLIASV DIHTKSQYHN YAIDWQTGAG CDAAGFFTVF ASELSVYTLT AITLERWHTI THAMQLECKV QLRHAASVMV LGWTFAFAAA LFPIFGISSY MKVSICLPMD IDSPLSQLYV MALLVLNVLA FVVICGCYTH IYLTVRNPTI VSSSSDTKIA KRMATLIFTD FLCMAPISFF AISASLKVPL ITVSKAKILL VLFYPINSCA NPFLYAIFTK NFRRDFFILL SKFGCYEMQA QIYRTETSSA THNFHARKSH CSSAPRVTNS YVLVPLNHSS QN // ID LSHR_MOUSE STANDARD; PRT; 700 AA. AC P30730; DT 01-APR-1993 (Rel. 25, Created) DT 01-APR-1993 (Rel. 25, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) DE (LSH-R) (Luteinizing hormone receptor). GN LHCGR OR LHR. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=92165799; PubMed=1311310; RA Gudermann T., Birnbaumer M., Birnbaumer L.; RT "Evidence for dual coupling of the murine luteinizing hormone RT receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ RT mobilization. Studies with the cloned murine luteinizing hormone RT receptor expressed in L cells."; RL J. Biol. Chem. 267:4479-4488(1992). RN [2] RP SEQUENCE OF 1-58 FROM N.A. RX MEDLINE=93093308; PubMed=1459341; RA Huhtaniemi I.T., Eskola V., Pakarinen P., Matikainen T., Sprengel R.; RT "The murine luteinizing hormone and follicle-stimulating hormone RT receptor genes: transcription initiation sites, putative promoter RT sequences and promoter activity."; RL Mol. Cell. Endocrinol. 88:55-66(1992). CC -!- FUNCTION: RECEPTOR FOR LUTROPIN-CHORIOGONADOTROPIC HORMONE. CC THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH CC ACTIVATE ADENYLATE CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC FSH/LSH/TSH SUBFAMILY. CC -!- SIMILARITY: Contains 4 leucine-rich (LRR) repeats. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S49753; AAB24402.1; -. DR EMBL; M81310; AAA39432.1; -. DR EMBL; M87571; AAA39433.1; -. DR PIR; A42395; A42395. DR HSSP; P22888; 1LUT. DR MGD; MGI:96783; Lhcgr. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001611; LRR. DR InterPro; IPR000372; LRR_Nterm. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF00560; LRR; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM00013; LRRNT; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Phosphorylation; Repeat; Leucine-rich repeat. FT SIGNAL 1 26 BY SIMILARITY. FT CHAIN 27 700 LUTROPIN-CHORIOGONADOTROPIC HORMONE FT RECEPTOR. FT DOMAIN 27 362 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 363 390 1 (POTENTIAL). FT DOMAIN 391 399 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 400 422 2 (POTENTIAL). FT DOMAIN 423 443 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 444 466 3 (POTENTIAL). FT DOMAIN 467 486 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 487 509 4 (POTENTIAL). FT DOMAIN 510 529 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 530 551 5 (POTENTIAL). FT DOMAIN 552 574 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 575 598 6 (POTENTIAL). FT DOMAIN 599 609 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 610 631 7 (POTENTIAL). FT DOMAIN 632 700 CYTOPLASMIC (POTENTIAL). FT REPEAT 52 75 LRR 1. FT REPEAT 126 150 LRR 2. FT REPEAT 176 200 LRR 3. FT REPEAT 225 248 LRR 4. FT DISULFID 443 518 BY SIMILARITY. FT CARBOHYD 103 103 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 178 178 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 199 199 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 295 295 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 303 303 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 317 317 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 700 AA; 78214 MW; 8A6840A011E1E014 CRC64; MGRRVPALRQ LLVLAMLVLK QSQLHSPELS GSRCPEPCDC APDGALRCPG PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSEILIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVSKISS SEFNFILEIC DNLYITTIPG NAFQGMNNES ITLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG TFQGATGPSI LDVSSTKLQA LPSHGLESIQ TLIATSSYSL KTLPSREKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI FENFSKQCES TVREANNETL YSAIFEENEL SGWDYDYDFC SPKTLQCTPE PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCSAAGFFT VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWIFSTL MATLPLVGVS SYMKVSICLP MDVESTLSQV YILSILLLNA VAFVVICACY VRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV PLITVTNSKV LLVLFYPVNS CANPFLYAVF TKAFQRDFFL LLSRFGCCKH RAELYRRKEF SACTFNSKNG FPRSSKPSQA ALKLSIVHCQ QPTPPRVLIQ // ID OPSF_ANGAN STANDARD; PRT; 352 AA. AC Q90215; DT 15-DEC-1998 (Rel. 37, Created) DT 15-DEC-1998 (Rel. 37, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin, freshwater form. OS Anguilla anguilla (European freshwater eel). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae; OC Anguilla. OX NCBI_TaxID=7936; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=96156843; PubMed=8587887; RA Archer S., Hope A., Partridge J.C.; RT "The molecular basis for the green-blue sensitivity shift in the rod RT visual pigments of the European eel."; RL Proc. R. Soc. Lond., B, Biol. Sci. 262:289-295(1995). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- DEVELOPMENTAL STAGE: When eel matures sexually and migrates back CC to deep sea breeding grounds the visual pigments in its rod CC photoreceptors change from being maximally sensitive to green CC light to being maximally sensitive to blue light. In part, this CC change in sensitivity is due to a change in the opsin component of CC the visual pigment molecule; this green sensitive rhodopsin is CC expressed during life in greener inland and coastal waters. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at around 501-523 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L78007; AAA99200.1; -. DR HSSP; P02699; 1EDS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic (Potential). FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular (Potential). FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic (Potential). FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular (Potential). FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic (Potential). FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular (Potential). FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 352 Cytoplasmic (Potential). FT DOMAIN 329 332 Poly-Glu. FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 352 AA; 39468 MW; 6E578919D6679DB4 CRC64; MNGTEGPNFY VPMSNVTGVV RSPFEYPQYY LAEPWAYSAL AAYMFFLIIA GFPINFLTLY VTIEHKKLRT PLNYILLNLA VADLFMVFGG FTTTMYTSMH GYFVFGPTGC NIEGFFATLG GEIALWCLVV LAVERWMVVC KPMSNFRFGE NHAIMGVAFT WVMALACAAP PLFGWSRYIP EGMQCSCGMD HYAPNPETYN ESFVIYMFIC HFTIPLTVIS FCYGRLVCTV KEATAQQQES ETTQRAEREV TRMVIIMVIS FLVCWVPYAS VAWYIFTHQG SSFGPIFMTI PAFFAKSSSL YNPLIYICMN KQSRNCMITT LCCGKNPFEE EEGASTTASK TEASSVSSVS PA // ID OPSD_SALPV STANDARD; PRT; 354 AA. AC Q9YGZ3; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Salaria pavo (Peacock blenny) (Lipophrys pavo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Blennioidei; OC Blenniidae; Salaria. OX NCBI_TaxID=152553; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RA Archer S.N., Hirano J.; RT "Comparative analysis of opsins in Mediterranian coastal fish."; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y18674; CAA77256.1; -. DR HSSP; P02699; 1EDS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 354 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 354 AA; 39543 MW; BBA1D0B69D4E2C29 CRC64; MNGTEGPYFY IPMVNTTGIV RSPYEYPQYY LVNPAAYAAL GAYMFFLILL GFPINFLTLY VTLEHKKLRT PLNYILLNLA VADLFMVFGG FTTTMYTSMH GYFVLGRLGC NLEGFFATLG GEIGLWSLVV LAIERWVVVC KPISNFRFGE NHAIMGLAFT WIMACACAVP PLVGWSRYIP EGMQCSCGVD YYTRAEGFNN ESFVVYMFTC HFCIPLTIIG FCYGRLLCAV KEAAAAQQES ETTQRAEREV TRMVILMVVG FLVCWLPYAS VAWYIFSNQG SQFGPLFMTI PAFFAKSSSV YNPMIYICMN KQFRHCMITT LCCGKNPFEE EEGASTTASK TEASSVSSSS VSPA // ID OPSD_MACFA STANDARD; PRT; 348 AA. AC Q28886; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Rhodopsin. GN RHO. OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95122332; PubMed=7822161; RA Nickells R.W., Burgoyne C.F., Quigley H.A., Zack D.J.; RT "Cloning and characterization of rod opsin cDNA from the Old World RT monkey, Macaca fascicularis."; RL Invest. Ophthalmol. Vis. Sci. 36:72-82(1995). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S76579; AAB33079.2; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor; KW Acetylation. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 348 Cytoplasmic. FT MOD_RES 1 1 N-acetylmethionine (By similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT DISULFID 110 187 By similarity. FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT MOD_RES 343 343 Phosphoserine (by RK) (By similarity). SQ SEQUENCE 348 AA; 39062 MW; 87030C4EF07ABCBE CRC64; MNGTEGPNFY VPFSNATGVV RSPFEYPQYY LAEPWQFSML AAYMFLLIVL GFPINFLTLY VTVQHKKLRT PLNYILLNLA VADLFMVFGG FTTTLYTSLH GYFVFGPTGC NAEGFFATLG GEIALWSLVV LAIERYVVVC KPMSNFRFGE NHAIMGVAFT WVMALACAAP PLFGWSRYIP EGLQCSCGID YYTLKPEVNN ESFVIYMFVV HFTIPMIVIF FCYGQLVFTV KEARAQQQES ATTQKAEKEV TRMVIIMVIA FLICWVPYAS VAFYIFTHQG SNFGPIFMTI PAFFAKSASI YNPVIYIMMN KQFRNCMLTT ICCGKNPLGD DEASATVSKT ETSQVAPA // ID OPSD_BUFBU STANDARD; PRT; 354 AA. AC P56514; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Bufo bufo (European toad). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Bufo. OX NCBI_TaxID=8384; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98288405; PubMed=9533857; RA Fyhrquist N., Donner K., Hargrave P.A., McDowell J.H., Popp M.P., RA Smith W.C.; RT "Rhodopsins from three frog and toad species: sequences and RT functional comparisons."; RL Exp. Eye Res. 66:295-305(1998). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This receptor is coupled to the activation CC of phospholipase C. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U59921; AAB93704.1; -. DR HSSP; P02699; 1EDX. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 354 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT BINDING 296 296 Retinal chromophore. FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 354 AA; 39777 MW; 35C99992101AC919 CRC64; MNGTEGPNFY IPMSNKTGVV RSPFEYPQYY LAEPWQYSIL CAYMFLLILL GFPINFMTLY VTIQHKKLRT PLNYILLNLA FANHFMVLCG FTVTMYSSMN GYFILGATGC YVEGFFATLG GEIALWSLVV LAIERYVVVC KPMSNFRFSE NHAVMGVAFT WIMALSCAVP PLLGWSRYIP EGMQCSCGVD YYTLKPEVNN ESFVIYMFVV HFTIPLIIIF FCYGRLVCTV KEAAAQQQES ATTQKAEKEV TRMVIIMVVF FLICWVPYAS VAFFIFSNQG SEFGPIFMTV PAFFAKSSSI YNPVIYIMLN KQFRNCMITT LCCGKNPFGE DDASSAATSK TEASSVSSSQ VSPA // ID OPSD_CHICK STANDARD; PRT; 351 AA. AC P22328; DT 01-AUG-1991 (Rel. 19, Created) DT 01-AUG-1991 (Rel. 19, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Rhodopsin. GN RHO. OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=89059271; PubMed=3195056; RA Takao M., Yasui A., Tokunaga F.; RT "Isolation and sequence determination of the chicken rhodopsin gene."; RL Vision Res. 28:471-480(1988). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at 503 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D00702; BAA00610.1; -. DR PIR; S29152; S29152. DR HSSP; P02699; 1L9H. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 351 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT DISULFID 110 187 By similarity. FT BINDING 296 296 Retinal chromophore. FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT MOD_RES 341 341 Phosphoserine (by RK) (By similarity). SQ SEQUENCE 351 AA; 39327 MW; 6AB91520EF818756 CRC64; MNGTEGQDFY VPMSNKTGVV RSPFEYPQYY LAEPWKFSAL AAYMFMLILL GFPVNFLTLY VTIQHKKLRT PLNYILLNLV VADLFMVFGG FTTTMYTSMN GYFVFGVTGC YIEGFFATLG GEIALWSLVV LAVERYVVVC KPMSNFRFGE NHAIMGVAFS WIMAMACAAP PLFGWSRYIP EGMQCSCGID YYTLKPEINN ESFVIYMFVV HFMIPLAVIF FCYGNLVCTV KEAAAQQQES ATTQKAEKEV TRMVIIMVIA FLICWVPYAS VAFYIFTNQG SDFGPIFMTI PAFFAKSSAI YNPVIYIVMN KQFRNCMITT LCCGKNPLGD EDTSAGKTET SSVSTSQVSP A // ID OPSD_GOBNI STANDARD; PRT; 352 AA. AC Q9YGZ2; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Gobius niger (Black goby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Gobioidei; OC Gobiidae; Gobius. OX NCBI_TaxID=85417; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RA Archer S.N., Hirano J.; RT "Comparative analysis of opsins in Mediterranian coastal fish."; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y18675; CAA77257.1; -. DR HSSP; P02699; 1EDV. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 352 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 352 AA; 39363 MW; C96CB55473F925B9 CRC64; MNGTEGPFFY IPMVNTTGVV RSPYEYPQYY LVNPAAYACL GAYMFFLILV GFPVNFLTLY VTLEHKKLRT PLNYILLNLA VADLFMVFGG FTTTIYTSMH GYFVLGRLGC NIEGFFATLG GEIALWSLVV LAIERWVVVC KPISNFRFGE NHAIMGVAFT WFMASACAVP PLVGWSRYIP EGMQCSCGID YYTRAEGFNN ESFVIYMFTV HFCIPLAVVG FCYGRLLCAV KEAAAAQQES ETTQRAEREV SRMVVIMVIG FLVCWLPYAS VAWYIFTHQG SEFGPLFMTI PAFFAKSSSI YNPMIYICMN KQFRHCMITT LCCGKNPFEE EEGASTTKTE ASSVSSSSVS PA // ID OPSD_MOUSE STANDARD; PRT; 348 AA. AC P15409; DT 01-APR-1990 (Rel. 14, Created) DT 01-APR-1990 (Rel. 14, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Rhodopsin. GN RHO. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=89005694; PubMed=2844600; RA Baehr W., Falk J.D., Bugra K., Triantafyllos J.T., McGinnis J.F.; RT "Isolation and analysis of the mouse opsin gene."; RL FEBS Lett. 238:253-256(1988). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=91056108; PubMed=1978723; RA Al-Ubaidi M.R., Pittler S.J., Champagne M.S., Triantafyllos J.T., RA McGinnis J.F., Baehr W.; RT "Mouse opsin. Gene structure and molecular basis of multiple RT transcripts."; RL J. Biol. Chem. 265:20563-20569(1990). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at 495 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M36699; AAA39861.1; -. DR EMBL; M36695; AAA39861.1; JOINED. DR EMBL; M36696; AAA39861.1; JOINED. DR EMBL; M36697; AAA39861.1; JOINED. DR EMBL; M36698; AAA39861.1; JOINED. DR EMBL; M55171; AAA63392.1; -. DR PIR; A23665; A23665. DR HSSP; P02699; 1EDS. DR MGD; MGI:97914; Rho. DR GO; GO:0001750; C:photoreceptor outer segment; IDA. DR GO; GO:0009583; P:detection of light; IMP. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor; KW Acetylation. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 348 Cytoplasmic. FT MOD_RES 1 1 N-acetylmethionine (By similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT BINDING 296 296 Retinal chromophore. FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. FT MOD_RES 343 343 Phosphoserine (by RK) (By similarity). SQ SEQUENCE 348 AA; 39028 MW; F73BB44F61EFF70C CRC64; MNGTEGPNFY VPFSNVTGVG RSPFEQPQYY LAEPWQFSML AAYMFLLIVL GFPINFLTLY VTVQHKKLRT PLNYILLNLA VADLFMVFGG FTTTLYTSLH GYFVFGPTGC NLEGFFATLG GEIALWSLVV LAIERYVVVC KPMSNFRFGE NHAIMGVVFT WIMALACAAP PLVGWSRYIP EGMQCSCGID YYTLKPEVNN ESFVIYMFVV HFTIPMIVIF FCYGQLVFTV KEAAAQQQES ATTQKAEKEV TRMVIIMVIF FLICWLPYAS VAFYIFTHQG SNFGPIFMTL PAFFAKSSSI YNPVIYIMLN KQFRNCMLTT LCCGKNPLGD DDASATASKT ETSQVAPA // ID OPSD_RANTE STANDARD; PRT; 354 AA. AC P56516; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Rana temporaria (European common frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana. OX NCBI_TaxID=8407; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98288405; PubMed=9533857; RA Fyhrquist N., Donner K., Hargrave P.A., McDowell J.H., Popp M.P., RA Smith W.C.; RT "Rhodopsins from three frog and toad species: sequences and RT functional comparisons."; RL Exp. Eye Res. 66:295-305(1998). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This receptor is coupled to the activation CC of phospholipase C. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U59920; AAB93706.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 354 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT BINDING 296 296 Retinal chromophore. FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 354 AA; 39978 MW; F51D966CDA985F32 CRC64; MNGTEGPNFY IPMSNKTGVV RSPFEYPQYY LAEPWKYSIL AAYMFLLILL GFPINFMTLY VTIQHKKLRT PLNYILLNLA FANHFMVLCG FTITLYTSLH GYFVFGQSGC YFEGFFATLG GEIALWSLVA LAIERYIVVC KPMSNFRFGE NHAMMGVAFT WIMALACAVP PLFGWSRYIP EGMQCSCGVD YYTLKPEINN ESFVIYMFVV HFLIPLIIIT FCYGRLVCTV KEAAAQQQES ATTQKAEKEV TRMVIIMVIF FLICWVPYAY VAFYIFCNQG SEFGPIFMTV PAFFAKSSAI YNPVIYIMLN KQFRNCMITT LCCGKNPFGD DDASSAATSK TEATSVSTSQ VSPA // ID OPSD_CYPCA STANDARD; PRT; 354 AA. AC P51488; O42325; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Cyprinus carpio (Common carp). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Cyprinus. OX NCBI_TaxID=7962; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=95144442; PubMed=7842230; RA Tsai H.J., Shih S.R., Kuo C.M., Li L.K.; RT "Molecular cloning of the common carp (Cyprinus carpio) rhodopsin RT cDNA."; RL Comp. Biochem. Physiol. 109B:81-88(1994). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=97320625; PubMed=9177476; RA Lim J., Chong J., Tsai H.J.; RT "A second type of rod opsin cDNA from the common carp (Cyprinus RT carpio)."; RL Biochim. Biophys. Acta 1352:8-12(1997). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U02475; AAB06368.1; -. DR EMBL; S74449; AAB33306.1; -. DR EMBL; Z71999; CAA96518.1; -. DR HSSP; P02699; 1EDS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic (Potential). FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular (Potential). FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic (Potential). FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular (Potential). FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic (Potential). FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular (Potential). FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 354 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT DISULFID 110 187 By similarity. FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT CONFLICT 19 19 V -> I (in Ref. 2). FT CONFLICT 54 54 I -> V (in Ref. 2). FT CONFLICT 108 108 I -> V (in Ref. 2). FT CONFLICT 169 170 VP -> EA (in Ref. 2). FT CONFLICT 225 225 R -> L (in Ref. 2). FT CONFLICT 315 315 H -> N (in Ref. 2). SQ SEQUENCE 354 AA; 39812 MW; DB5E3584A4250EE6 CRC64; MNGTEGPMFY VPMSNATGVV KSPYDYPQYY LVAPWAYGCL AAYMFFLIIT GFPINFLTLY VTIEHKKLRT PLNYILLNLA ISDLFMVFGG FTTTMYTSLH GYFVFGRIGC NLEGFFATLG GEMGLWSLVV LAFERWMVVC KPVSNFRFGE NHAIMGVVFT WFMACTCAVP PLVGWSRYIP EGMQCSCGVD YYTRAPGYNN ESFVIYMFLV HFIIPLIVIF FCYGRLVCTV KDAAAQQQES ETTQRAEREV TRMVVIMVIG FLICWIPYAS VAWYIFTHQG SEFGPVFMTV PAFFAKSAAV YNPCIYICMN KQFRHCMITT LCCGKNPFEE EEGASTTASK TEASSVSSSS VSPA // ID OPSD_POMMI STANDARD; PRT; 352 AA. AC P35403; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Pomatoschistus minutus (Sand goby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Gobioidei; OC Gobiidae; Pomatoschistus. OX NCBI_TaxID=13225; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=92396703; PubMed=1381834; RA Archer S.N., Lythgoe J.N., Hall L.; RT "Rod opsin cDNA sequence from the sand goby (Pomatoschistus minutus) RT compared with those of other vertebrates."; RL Proc. R. Soc. Lond., B, Biol. Sci. 248:19-25(1992). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at 501 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X62405; CAA44275.1; -. DR PIR; S40688; S40688. DR HSSP; P02699; 1EDV. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 352 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 352 AA; 39409 MW; 8B8CE379AFED4656 CRC64; MNGTEGPFFY IPMVNTTGIV RSPYEYPQYY LVNPAAYAAL GAYMFFLILT GFPINFLTLY VTLEHKKLRT ALNLILLNLA VADLFMVFGG FTTTMYTSMH GYFVLGRLGC NVEGFFATLG GEIALWSLVV LAVERWVVVC KPISNFRFTE NHAIMGVAFS WIMAATCAVP PLVGWSRYIP EGMQCSCGVD YYTRAEGFNN ESFVIYMFIV HFLAPLIVIF FCYGRLLCAV KEAAAAQQES ETTQRAEREV TRMVIIMVIG FLTSWLPYAS VAWYIFTHQG TEFGPLFMTI PAFFAKSSAL YNPMIYICMN KQFRHCMITT LCCGKNPFEE EEGASTTKTE ASSVSSSSVS PA // ID OPSD_NEOSA STANDARD; PRT; 351 AA. AC P79812; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Neoniphon sammara (Spotfin squirrelfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Beryciformes; Holocentridae; OC Neoniphon. OX NCBI_TaxID=47706; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Eye; RA Toller W.W., Moses K., McFall-Ngai M.J.; RT "Molecular phylogeny of 11 holocentrid fishes (Order Beryciformes) RT inferred from rhodopsin cDNA and cytochrome b."; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U57536; AAB39524.1; -. DR HSSP; P02699; 1EDV. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic (Potential). FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular (Potential). FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic (Potential). FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular (Potential). FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic (Potential). FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular (Potential). FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 351 Cytoplasmic (Potential). FT DISULFID 110 187 By similarity. FT BINDING 296 296 Retinal chromophore (By similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 351 AA; 39369 MW; 6EF83053459E2C93 CRC64; MNGTEGPYFY VPMVNTTGVV RSPYEYPQYY LVNPAAFAVL GAYMFFLIIF GFPINFLTLY VTLEHKKLRT PLNYILLNLA VADLFMVIGG FTTTMYSSMH GYFVLGRLGC NLEGFSATLG GMISLWSLAV LAIERWVVVC KPTSNFRFGE NHAIMGVSLT WTMALACTVP PLVGWSRYIP EGMQCSCGID YYTRAEGFNN ESFVLYMFFC HFMVPLIIIF FCYGRLLCAV KEAAAAQQES ETTQRAEREV TRMVILMVIG YLVCWLPYAS VAWFIFTHQG SEFGPLFMTI PAFFAKSSSI YNPVIYICMN KQFRNCMITT LFCGKNPFEG EEEGASSTKT EASSASSVSP A // ID OPSD_SARMI STANDARD; PRT; 348 AA. AC P79901; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin (Fragment). GN RHO. OS Sargocentron microstoma (Smallmouth squirrelfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Beryciformes; Holocentridae; OC Sargocentron. OX NCBI_TaxID=47710; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Eye; RA Toller W.W., Moses K., McFall-Ngai M.J.; RT "Molecular phylogeny of 11 holocentrid fishes (Order Beryciformes) RT inferred from rhodopsin cDNA and cytochrome b."; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U57542; AAB39528.1; -. DR HSSP; P02699; 1BOJ. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT NON_TER 1 1 FT DOMAIN <1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT DOMAIN 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 95 2 (Potential). FT DOMAIN 96 110 Extracellular (Potential). FT TRANSMEM 111 130 3 (Potential). FT DOMAIN 131 149 Cytoplasmic (Potential). FT TRANSMEM 150 173 4 (Potential). FT DOMAIN 174 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 249 Cytoplasmic (Potential). FT TRANSMEM 250 273 6 (Potential). FT DOMAIN 274 281 Extracellular (Potential). FT TRANSMEM 282 306 7 (Potential). FT DOMAIN 307 348 Cytoplasmic (Potential). FT DISULFID 107 184 By similarity. FT BINDING 293 293 Retinal chromophore (By similarity). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential). FT LIPID 320 320 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 348 AA; 39162 MW; EFB4BF08E1D4464F CRC64; TEGPYFYIPM VNTTGIVRSP YEYPQYYLVN PAAYAMLGAY MFFLIIVGFP VNFMTLYVTL EHKKLRTPLN YILLNLAVAD LFMVIGGFTT TIYTSMHGYF VLGRLGCNIE GFFATLGGMI SLWSLAVLAI ERWVVVCKPI SNFRFGENHA IMGVSLTWAM ALACTVPPLV GWSRYIPEGM QCSCGIDYYT RAEGFNNESF VLYMFFCHFT IPLTIIFFCY GRLLCAVKEA AAAQQESETT QRAEREVTRM VIIMVIGFLI CWLPYASVAW FIFTHQGSEF GPLFMTIPAF FAKSSSIYNP MIYICMNKQF RHCMITTLFC GKNPFEGEEE GASSTKTEAS SASSVSPA // ID OPSB_ANOCA STANDARD; PRT; 355 AA. AC P51471; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Blue-sensitive opsin (Blue photoreceptor pigment) (RH2 opsin). OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Iguania; Iguanidae; Polychrotinae; Anolis. OX NCBI_TaxID=28377; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95371134; PubMed=7643409; RA Kawamura S., Yokoyama S.; RT "Paralogous origin of the rhodopsinlike opsin genes in lizards."; RL J. Mol. Evol. 40:594-600(1995). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This opsin uses a vitamin A2 chromophore. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- MISCELLANEOUS: Maximal absorption at probably 503 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S79167; AAB35062.1; -. DR EMBL; S79124; AAB35062.1; JOINED. DR EMBL; S79134; AAB35062.1; JOINED. DR EMBL; S79165; AAB35062.1; JOINED. DR EMBL; S79166; AAB35062.1; JOINED. DR PIR; I51319; I51319. DR HSSP; P02699; 1EDX. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor; Lipoprotein; Palmitate. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 355 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 By similarity. FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 355 AA; 39983 MW; 555B671A4DE96EA6 CRC64; MNGTEGINFY VPLSNKTGLV RSPFEYPQYY LAEPWKYKVV CCYIFFLIFT GLPINILTLL VTFKHKKLRQ PLNYILVNLA VADLFMACFG FTVTFYTAWN GYFIFGPIGC AIEGFFATLG GQVALWSLVV LAIERYIVVC KPMGNFRFSA THALMGISFT WFMSFSCAAP PLLGWSRYIP EGMQCSCGPD YYTLNPDYHN ESYVLYMFGV HFVIPVVVIF FSYGRLICKV REAAAQQQES ASTQKAEREV TRMVILMVLG FLLAWTPYAM VAFWIFTNKG VDFSATLMSV PAFFSKSSSL YNPIIYVLMN KQFRNCMITT ICCGKNPFGD EDVSSSVSQS KTEVSSVSSS QVSPA // ID OPSD_SARTI STANDARD; PRT; 347 AA. AC P79911; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin (Fragment). GN RHO. OS Sargocentron tiere (Blue lined squirrelfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Beryciformes; Holocentridae; OC Sargocentron. OX NCBI_TaxID=47713; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Eye; RA Toller W.W., Moses K., McFall-Ngai M.J.; RT "Molecular phylogeny of 11 holocentrid fishes (Order Beryciformes) RT inferred from rhodopsin cDNA and cytochrome b."; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U57545; AAB39534.1; -. DR HSSP; P02699; 1BOJ. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT NON_TER 1 1 FT DOMAIN <1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT DOMAIN 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 95 2 (Potential). FT DOMAIN 96 110 Extracellular (Potential). FT TRANSMEM 111 130 3 (Potential). FT DOMAIN 131 149 Cytoplasmic (Potential). FT TRANSMEM 150 173 4 (Potential). FT DOMAIN 174 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 249 Cytoplasmic (Potential). FT TRANSMEM 250 273 6 (Potential). FT DOMAIN 274 281 Extracellular (Potential). FT TRANSMEM 282 306 7 (Potential). FT DOMAIN 307 347 Cytoplasmic (Potential). FT DISULFID 107 184 By similarity. FT BINDING 293 293 Retinal chromophore (By similarity). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential). FT LIPID 320 320 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 347 AA; 39135 MW; 19A437B9CD7793F5 CRC64; TEGPDFYIPM VNTTGVVRSP YEYPQYYLVN PAAFAVLGAY MFFLIIIGFP INFLTLYVTL EHKKLRTPLN YILLNLAVAD LFMVIGGFTT TMYSSMHGYF VLGRLGCNIE GFFATLGGMI SLWSLAVLAI ERWVVVCKPI SNFRFGENHA IMGVSLTWVM ALACTVPPLV GWSRYIPEGM QCACGIDYYT RAEGYNNESF VIYMFTFHFL FPMFIIFFCY GRLLCAVKEA AAAQQESETT QRAEREVTRM VILMVIGYLV CWLPYASVAW FIFTHKGSEF GPLFMAVPSF FAKSSSIYNP IIYICMNKQF RQCMITTLFC GKNPFEGQEE DSSTKTEASS ASSVSPA // ID OPSI_ASTFA STANDARD; PRT; 354 AA. AC P51474; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Green-sensitive opsin 3 (Green cone photoreceptor pigment 3). GN RH11. OS Astyanax fasciatus (Blind cave fish) (Astyanax mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characidae; Astyanax. OX NCBI_TaxID=7994; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95018302; PubMed=7932788; RA Register E.A., Yokoyama R., Yokoyama S.; RT "Multiple origins of the green-sensitive opsin genes in fish."; RL J. Mol. Evol. 39:268-273(1994). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The color pigments are found in the cone CC photoreceptor cells. CC -!- MISCELLANEOUS: THIS FISH POSSESSES THREE GENES FOR GREEN OPSIN. CC TWO (G103 AND G101) THAT BELONG TO THE LWS/MWS GROUP AND ONE CC (RH11) THAT BELONGS TO THE RH2 GROUP. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S75255; AAB32221.2; -. DR EMBL; S75251; AAB32221.2; JOINED. DR EMBL; S75252; AAB32221.2; JOINED. DR EMBL; S75253; AAB32221.2; JOINED. DR EMBL; S75254; AAB32221.2; JOINED. DR PIR; I51266; I51266. DR HSSP; P02699; 1BOJ. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 39 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 40 64 1 (POTENTIAL). FT DOMAIN 65 76 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 77 102 2 (POTENTIAL). FT DOMAIN 103 116 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 117 136 3 (POTENTIAL). FT DOMAIN 137 155 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 156 179 4 (POTENTIAL). FT DOMAIN 180 205 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 206 233 5 (POTENTIAL). FT DOMAIN 234 255 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 256 279 6 (POTENTIAL). FT DOMAIN 280 287 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 288 312 7 (POTENTIAL). FT DOMAIN 313 354 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 203 203 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 113 190 POTENTIAL. FT BINDING 299 299 RETINAL CHROMOPHORE (BY SIMILARITY). SQ SEQUENCE 354 AA; 39117 MW; 023C474F9F08048A CRC64; MSGLNGFEGD NFYIPMSNRT GLVRDPFVYE QYYLAEPWQF KLLACYMFFL ICLGLPINGF TLFVTAQHKK LQQPLNFILV NLAVAGMIMV CFGFTITISS AVNGYFYFGP TACAIEGFMA TLGGEVALWS LVVLAIERYI VVCKPMGSFK FSASHALGGI GFTWFMAMTC AAPPLVGWSR YIPEGLQCSC GPDYYTLNPK YNNESYVIYM FVVHFIVPVT VIFFTYGRLV CTVKSAAAAQ QDSASTQKAE KEVTRMVILM VVGFLVAWTP YATVAAWIFF NKGAAFTAQF MAVPAFFSKS SALFNPIIYV LLNKQFRNCM LTTLFCGKNP LGDEESSTVS TKTEVSTVSS VSPA // ID OPSG_BRARE STANDARD; PRT; 349 AA. AC Q9W6A5; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Green-sensitive opsin 1 (Green cone photoreceptor pigment 1). GN OPN1MW1 OR GROPS1. OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP SEQUENCE FROM N.A., AND TISSUE SPECIFICITY. RC TISSUE=Eye; RX MEDLINE=99277479; PubMed=10349976; RA Vihtelic T.S., Doro C.J., Hyde D.R.; RT "Cloning and characterization of six zebrafish photoreceptor opsin RT cDNAs and immunolocalization of their corresponding proteins."; RL Vis. Neurosci. 16:571-585(1999). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Retinal double cone accessory photoreceptor CC cell outer segments. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF109369; AAD24752.1; -. DR HSSP; P02699; 1F88. DR ZFIN; ZDB-GENE-990604-42; opn1mw1. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0009881; F:photoreceptor activity; NAS. DR GO; GO:0007602; P:phototransduction; IC. DR GO; GO:0007601; P:visual perception; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic (Potential). FT TRANSMEM 74 99 2 (Potential). FT DOMAIN 100 113 Extracellular (Potential). FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic (Potential). FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular (Potential). FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic (Potential). FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular (Potential). FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 349 Cytoplasmic (Potential). FT DISULFID 110 187 Potential. FT BINDING 296 296 Retinal chromophore (By similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 349 AA; 38826 MW; 00E67718F5C7F44B CRC64; MNGTEGSNFY IPMSNRTGLV RSPYDYTQYY LAEPWKFKAL AFYMFLLIIF GFPINVLTLV VTAQHKKLRQ PLNYILVNLA FAGTIMVIFG FTVSFYCSLV GYMALGPLGC VMEGFFATLG GQVALWSLVV LAIERYIVVC KPMGSFKFSA NHAMAGIAFT WFMACSCAVP PLFGWSRYLP EGMQTSCGPD YYTLNPEYNN ESYVMYMFSC HFCIPVTTIF FTYGSLVCTV KAAAAQQQES ESTQKAEREV TRMVILMVLG FLFAWVPYAS FAAWIFFNRG AAFSAQAIAV PAFFSKTSAV FNPIIYVLLN KQFRSCMLNT LFCGKSPLGD DESSSVSTSK TEVSSVSPA // ID OPSG_SCICA STANDARD; PRT; 364 AA. AC O35478; Q9R023; DT 30-MAY-2000 (Rel. 39, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Green-sensitive opsin (Green cone photoreceptor pigment). GN OPN1MW OR GCP. OS Sciurus carolinensis (Gray squirrel). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Sciuridae; Sciurinae; OC Sciurus. OX NCBI_TaxID=30640; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99442393; PubMed=10511567; RA Yokoyama S., Radlwimmer F.B.; RT "The molecular genetics of red and green color vision in mammals."; RL Genetics 153:919-932(1999). RN [2] RP SEQUENCE OF 48-320 FROM N.A. RX MEDLINE=98242086; PubMed=9580985; RA Yokoyama S., Radlwimmer F.B.; RT "The 'five-sites' rule and the evolution of red and green color RT vision in mammals."; RL Mol. Biol. Evol. 15:560-567(1998). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone CC photoreceptor cells (By similarity). CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF132044; AAD30525.1; -. DR EMBL; AF031530; AAB86948.1; -. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00575; OPSINREDGRN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 52 Extracellular. FT TRANSMEM 53 77 1 (Potential). FT DOMAIN 78 89 Cytoplasmic (Potential). FT TRANSMEM 90 115 2 (Potential). FT DOMAIN 116 129 Extracellular (Potential). FT TRANSMEM 130 149 3 (Potential). FT DOMAIN 150 168 Cytoplasmic (Potential). FT TRANSMEM 169 192 4 (Potential). FT DOMAIN 193 218 Extracellular (Potential). FT TRANSMEM 219 246 5 (Potential). FT DOMAIN 247 268 Cytoplasmic (Potential). FT TRANSMEM 269 292 6 (Potential). FT DOMAIN 293 300 Extracellular (Potential). FT TRANSMEM 301 320 7 (Potential). FT DOMAIN 321 364 Cytoplasmic (Potential). FT DISULFID 126 203 Potential. FT BINDING 312 312 Retinal chromophore (By similarity). FT CONFLICT 216 216 V -> M (in Ref. 2). SQ SEQUENCE 364 AA; 40630 MW; B6CDD9B5639F0837 CRC64; MAQRWDPQRL AGGQPQDSHE DSTQSSIFTY TNSNATRGPF EGPNYHIAPR WVYHITSTWM IIVVIASVFT NGLVLVATMK FKKLRHPLNW ILVNLAIADL AETVIASTIS VVNQLYGYFV LGHPLCVVEG YTVSVCGITG LWSLAIISWE RWLVVCKPFG NMRFDAKLAI VGIAFSWIWS AVWTAPPIFG WSRYWPYGLK TSCGPDVFSG TSYPGVQSYM MVLMVTCCII PLSIIILCYL QVWLAIRAVA KQQKESESTQ KAEKEVTRMV VVMVFAYCLC WGPYTFFACF ATANPGYAFH PLVAALPAYF AKSATIYNPI IYVFMNRQFR NCILQLFGKK VDDTSELSSA SKTEASSVSS VSPA // ID OPSG_RABIT STANDARD; PRT; 364 AA. AC O18910; O62769; DT 15-JUL-1998 (Rel. 36, Created) DT 15-DEC-1998 (Rel. 37, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Green-sensitive opsin (Green cone photoreceptor pigment). GN OPN1MW OR GCP. OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Lagomorpha; Leporidae; Oryctolagus. OX NCBI_TaxID=9986; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98426163; PubMed=9751808; RA Radlwimmer F.B., Yokoyama S.; RT "Genetic analyses of the green visual pigments of rabbit (Oryctolagus RT cuniculus) and rat (Rattus norvegicus)."; RL Gene 218:103-109(1998). RN [2] RP SEQUENCE OF 48-320 FROM N.A. RX MEDLINE=98242086; PubMed=9580985; RA Yokoyama S., Radlwimmer F.B.; RT "The 'five-sites' rule and the evolution of red and green color RT vision in mammals."; RL Mol. Biol. Evol. 15:560-567(1998). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone CC photoreceptor cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: This opsin has an absorption maximum at 509 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF054240; AAC64919.1; -. DR EMBL; AF054235; AAC64919.1; JOINED. DR EMBL; AF054236; AAC64919.1; JOINED. DR EMBL; AF054237; AAC64919.1; JOINED. DR EMBL; AF054238; AAC64919.1; JOINED. DR EMBL; AF054239; AAC64919.1; JOINED. DR EMBL; AF031526; AAB86944.1; -. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00575; OPSINREDGRN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 52 Extracellular. FT TRANSMEM 53 77 1 (Potential). FT DOMAIN 78 89 Cytoplasmic. FT TRANSMEM 90 115 2 (Potential). FT DOMAIN 116 129 Extracellular. FT TRANSMEM 130 149 3 (Potential). FT DOMAIN 150 168 Cytoplasmic. FT TRANSMEM 169 192 4 (Potential). FT DOMAIN 193 218 Extracellular. FT TRANSMEM 219 246 5 (Potential). FT DOMAIN 247 268 Cytoplasmic. FT TRANSMEM 269 292 6 (Potential). FT DOMAIN 293 300 Extracellular. FT TRANSMEM 301 325 7 (Potential). FT DOMAIN 326 364 Cytoplasmic. FT CARBOHYD 34 34 N-linked (GlcNAc...) (Probable). FT DISULFID 126 203 Potential. FT BINDING 312 312 Retinal chromophore (By similarity). FT CONFLICT 247 248 RT -> PA (in Ref. 2). SQ SEQUENCE 364 AA; 40544 MW; B61B6B0F9DA0CAD8 CRC64; MTQPWGPQML AGGQPPESHE DSTQASIFTY TNSNSTRGPF EGPNFHIAPR WVYHLTSAWM ILVVIASVFT NGLVLVATMR FKKLRHPLNW ILVNLAVADL AETVIASTIS VVNQFYGYFV LGHPLCVVEG YTVSLCGITG LWSLAIISWE RWLVVCKPFG NVRFDAKLAI AGIAFSWIWA AVWTAPPIFG WSRYWPYGLK TSCGPDVFSG TSYPGVQSYM MVLMVTCCII PLSVIVLCYL QVWMAIRTVA KQQKESESTQ KAEKEVTRMV VVMVFAYCLC WGPYTFFACF ATAHPGYSFH PLVAAIPSYF AKSATIYNPI IYVFMNRQFR NCILQLFGKK VEDSSELSSA SRTEASSVSS VSPA // ID OPSG_CAVPO STANDARD; PRT; 364 AA. AC Q9R024; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Green-sensitive opsin (Green cone photoreceptor pigment). GN OPN1MW OR GCP. OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99442393; PubMed=10511567; RA Yokoyama S., Radlwimmer F.B.; RT "The molecular genetics of red and green color vision in mammals."; RL Genetics 153:919-932(1999). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone CC photoreceptor cells (By similarity). CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF132042; AAD30523.1; -. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00575; OPSINREDGRN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 52 Extracellular. FT TRANSMEM 53 77 1 (Potential). FT DOMAIN 78 89 Cytoplasmic. FT TRANSMEM 90 115 2 (Potential). FT DOMAIN 116 129 Extracellular. FT TRANSMEM 130 149 3 (Potential). FT DOMAIN 150 168 Cytoplasmic. FT TRANSMEM 169 192 4 (Potential). FT DOMAIN 193 218 Extracellular. FT TRANSMEM 219 246 5 (Potential). FT DOMAIN 247 268 Cytoplasmic. FT TRANSMEM 269 292 6 (Potential). FT DOMAIN 293 300 Extracellular. FT TRANSMEM 301 325 7 (Potential). FT DOMAIN 326 364 Cytoplasmic. FT CARBOHYD 34 34 N-linked (GlcNAc...) (Probable). FT DISULFID 126 203 Potential. FT BINDING 312 312 Retinal chromophore (By similarity). SQ SEQUENCE 364 AA; 40526 MW; A6373641C208782B CRC64; MAQRWGPHAL SGVQAQDAYE DSTQASLFTY TNSNNTRGPF EGPNYHIAPR WVYHLTSAWM TIVVIASIFT NGLVLVATMR FKKLRHPLNW ILVNLAVADL AETVIASTIS VVNQVYGYFV LGHPLCVVEG YTVSLCGITG LWSLAIISWE RWLVVCKPFG NVRFDAKLAI VGIVFSWVWS AVWTAPPIFG WSRYWPYGLK TSCGPDVFSG TSYPGVQSYM MVLMVTCCIT PLSIIVLCYL HVWLAIRAVA KQQKESESTQ KAEKEVTRMV VVMVLAYCLC WGPYAFFACF ATANPGYSFH PLVAALPAYF AKSATIYNPI IYVFMNRQFR NCILQLFGKK VEDSSELSST SRTEASSVSS VSPA // ID OPSB_PANTR STANDARD; PRT; 348 AA. AC P60015; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Blue-sensitive opsin (BOP) (Blue cone photoreceptor pigment). GN OPN1SW OR BCP. OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98210251; PubMed=9549095; RA Shimmin L.C., Miller J., Tran H.N., Li W.H.; RT "Contrasting levels of DNA polymorphism at the autosomal and X-linked RT visual color pigment loci in humans and squirrel monkeys."; RL Mol. Biol. Evol. 15:449-455(1998). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity). CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone CC photoreceptor cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- MISCELLANEOUS: Maximal absorption at 420 nm (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF039435; AAB95490.1; -. DR EMBL; AF039433; AAB95490.1; JOINED. DR EMBL; AF039434; AAB95490.1; JOINED. DR Pfam; PF00001; 7tm_1; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT DOMAIN 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 96 2 (Potential). FT DOMAIN 97 110 Extracellular (Potential). FT TRANSMEM 111 130 3 (Potential). FT DOMAIN 131 149 Cytoplasmic (Potential). FT TRANSMEM 150 173 4 (Potential). FT DOMAIN 174 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 249 Cytoplasmic (Potential). FT TRANSMEM 250 273 6 (Potential). FT DOMAIN 274 281 Extracellular (Potential). FT TRANSMEM 282 306 7 (Potential). FT DOMAIN 307 348 Cytoplasmic (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT DISULFID 107 184 Potential. FT BINDING 293 293 Retinal chromophore (By similarity). SQ SEQUENCE 348 AA; 39135 MW; 83FAB2E7111CB581 CRC64; MRKMSEEEFY LFKNISSVGP WDGPQYHIAP VWAFYLQAAF MGTVFLIGFP LNAMVLVATL RYKKLRQPLN YILVNVSFGG FLLCIFSVFP VFVASCNGYF VFGRHVCALE GFLGTVAGLV TGWSLAFLAF ERYIVICKPF GNFRFSSKHA LTVVLATWTI GIGVSIPPFF GWSRFIPEGL QCSCGPDWYT VGTKYRSESY TWFLFIFCFI VPLSLICFSY TQLLRALKAV AAQQQESATT QKAEREVSRM VVVMVGSFCV CYVPYAAFAM YMVNNRNHGL DLRLVTIPSF FSKSACIYNP IIYCFMNKQF QACIMKMVCG KAMTDESDTC SSQKTEVSTV SSTQVGPN // ID OPSH_ASTFA STANDARD; PRT; 353 AA. AC P22331; DT 01-AUG-1991 (Rel. 19, Created) DT 01-AUG-1991 (Rel. 19, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Green-sensitive opsin 2 (Green cone photoreceptor pigment 2). GN G101. OS Astyanax fasciatus (Blind cave fish) (Astyanax mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characidae; Astyanax. OX NCBI_TaxID=7994; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Pineal gland; RX MEDLINE=91067696; PubMed=2123554; RA Yokoyama R., Yokoyama S.; RT "Convergent evolution of the red- and green-like visual pigment genes RT in fish, Astyanax fasciatus, and human."; RL Proc. Natl. Acad. Sci. U.S.A. 87:9315-9318(1990). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The color pigments are found in the cone CC photoreceptor cells. CC -!- MISCELLANEOUS: THIS FISH POSSESSES THREE GENES FOR GREEN OPSIN. CC TWO (G103 AND G101) THAT BELONG TO THE LWS/MWS GROUP AND ONE CC (RH11) THAT BELONGS TO THE RH2 GROUP. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M38624; AAA62671.1; -. DR EMBL; M38619; AAA62671.1; JOINED. DR EMBL; M38620; AAA62671.1; JOINED. DR EMBL; M38621; AAA62671.1; JOINED. DR EMBL; M38622; AAA62671.1; JOINED. DR EMBL; M38623; AAA62671.1; JOINED. DR PIR; A38421; A38421. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 47 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 48 72 1 (POTENTIAL). FT DOMAIN 73 84 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 85 110 2 (POTENTIAL). FT DOMAIN 111 124 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 125 144 3 (POTENTIAL). FT DOMAIN 145 163 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 164 187 4 (POTENTIAL). FT DOMAIN 188 213 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 214 241 5 (POTENTIAL). FT DOMAIN 242 263 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 264 287 6 (POTENTIAL). FT DOMAIN 288 295 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 296 320 7 (POTENTIAL). FT DOMAIN 321 353 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 29 29 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 121 198 POTENTIAL. FT BINDING 307 307 RETINAL CHROMOPHORE. SQ SEQUENCE 353 AA; 39465 MW; A7E7B8296AD93253 CRC64; MAAHEPVFAA RRHNEDTTRE SAFVYTNANN TRDPFEGPNY HIAPRWVYNV SSLWMIFVVI ASVFTNGLVI VATAKFKKLR HPLNWILVNL AIADLGETVL ASTISVINQI FGYFILGHPM CVFEGWTVSV CGITALWSLT IISWERWVVV CKPFGNVKFD GKWAAGGIIF SWVWAIIWCT PPIFGWSRYW PHGLKTSCGP DVFSGSEDPG VASYMITLML TCCILPLSII IICYIFVWSA IHQVAQQQKD SESTQKAEKE VSRMVVVMIL AFIVCWGPYA SFATFSAVNP GYAWHPLAAA MPAYFAKSAT IYNPIIYVFM NRQFRSCIMQ LFGKKVEDAS EVSGSTTEVS TAS // ID OPSV_ORYLA STANDARD; PRT; 334 AA. AC P87368; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Putative violet-sensitive opsin (Violet cone photoreceptor pigment) DE (KFH-V). OS Oryzias latipes (Medaka fish) (Japanese ricefish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Atherinomorpha; OC Beloniformes; Adrianichthyidae; Oryziinae; Oryzias. OX NCBI_TaxID=8090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RA Hisatomi O., Satoh T., Tokunaga F.; RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone CC photoreceptor cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB001605; BAA19422.1; -. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00574; OPSINBLUE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 29 Extracellular (Potential). FT TRANSMEM 30 54 1 (Potential). FT DOMAIN 55 66 Cytoplasmic (Potential). FT TRANSMEM 67 88 2 (Potential). FT DOMAIN 89 106 Extracellular (Potential). FT TRANSMEM 107 126 3 (Potential). FT DOMAIN 127 145 Cytoplasmic (Potential). FT TRANSMEM 146 168 4 (Potential). FT DOMAIN 169 194 Extracellular (Potential). FT TRANSMEM 195 222 5 (Potential). FT DOMAIN 223 244 Cytoplasmic (Potential). FT TRANSMEM 245 272 6 (Potential). FT DOMAIN 273 279 Extracellular (Potential). FT TRANSMEM 280 301 7 (Potential). FT DOMAIN 302 334 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT DISULFID 103 179 Potential. FT BINDING 288 288 Retinal chromophore. SQ SEQUENCE 334 AA; 37393 MW; 557422B64F75580F CRC64; MGKYFYLYEN ISKVGPYDGP QYYLAPTWAF YLQAAFMGFV FFVGTPLNFV VLLATAKYKK LRVPLNYILV NITFAGFIFV TFSVSQVFLA SVRGYYFFGQ TLCALEAAVG AVAGLVTSWS LAVLSFERYL VICKPFGAFK FGSNHALAAV IFTWFMGVVR CPPFFGWSRY IPEGLGCSCG PDWYTNCEEF SCASYSKFLL VTCFICPITI IIFSYSQLLG ALRAVAAQQA ESASTQKAEK EVSRMIIVMV ASFVTCYGPY ALTAQYYAYS QDENKDYRLV TIPAFFSKSS CVYNPLIYAF MNKQFNGCIM EMVFGKKMEE ASEVSSKTEV STDS // ID OPN3_MOUSE STANDARD; PRT; 400 AA. AC Q9WUK7; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Opsin 3 (Encephalopsin) (Panopsin). GN OPN3 OR ECPN. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99252448; PubMed=10234000; RA Blackshaw S., Snyder S.H.; RT "Encephalopsin: a novel mammalian extraretinal opsin discretely RT localized in the brain."; RL J. Neurosci. 19:3681-3690(1999). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6; RA Rump A., Taudien S., Rieder M., Rosenthal A.; RT "Different structural organisation of the encephalopsin gene in man RT and mouse."; RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6J; TISSUE=Cerebellum; RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). CC -!- FUNCTION: May play a role in encephalic photoreception. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF140241; AAD32670.1; -. DR EMBL; AF482427; AAO15719.1; -. DR EMBL; AK043135; BAC31471.1; -. DR HSSP; P02699; 1FDF. DR MGD; MGI:1338022; Opn3. DR GO; GO:0016021; C:integral to membrane; ISS. DR GO; GO:0008020; F:G-protein coupled photoreceptor activity; ISS. DR GO; GO:0007602; P:phototransduction; ISS. DR GO; GO:0042752; P:regulation of circadian rhythm; ISS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Lipoprotein; Palmitate; KW G-protein coupled receptor. FT DOMAIN 1 38 Extracellular (Potential). FT TRANSMEM 39 63 1 (Potential). FT DOMAIN 64 75 Cytoplasmic (Potential). FT TRANSMEM 76 100 2 (Potential). FT DOMAIN 101 115 Extracellular (Potential). FT TRANSMEM 116 135 3 (Potential). FT DOMAIN 136 151 Cytoplasmic (Potential). FT TRANSMEM 152 175 4 (Potential). FT DOMAIN 176 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 253 Cytoplasmic (Potential). FT TRANSMEM 254 277 6 (Potential). FT DOMAIN 278 285 Extracellular (Potential). FT TRANSMEM 286 310 7 (Potential). FT DOMAIN 311 400 Cytoplasmic (Potential). FT DISULFID 112 186 By similarity. FT BINDING 297 297 Retinal chromophore. FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 196 196 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 400 AA; 44946 MW; AAFA81386C48BDB5 CRC64; MYSGNRSGDQ GYWEDGAGAE GAAPAGTRSP APLFSPTAYE RLALLLGCLA LLGVGGNLLV LLLYSKFPRL RTPTHLFLVN LSLGDLLVSL FGVTFTFASC LRNGWVWDAV GCAWDGFSGS LFGFVSITTL TVLAYERYIR VVHARVINFS WAWRAITYIW LYSLAWAGAP LLGWNRYILD IHGLGCTVDW RSKDANDSSF VLFLFLGCLV VPVGIIAHCY GHILYSVRML RCVEDLQTIQ VIKMLRYEKK VAKMCFLMAF VFLTCWMPYI VTRFLVVNGY GHLVTPTVSI VSYLFAKSST VYNPVIYIFM NRKFRRSLLQ LLCFRLLRCQ RPAKNLPAAE SEMHIRPIVM SQKDGDRPKK KVTFNSSSII FIITSDESLS VEDSDRSSAS KVDVIQVRPL // ID OPS2_SCHGR STANDARD; PRT; 380 AA. AC Q26495; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Opsin 2. GN LO2. OS Schistocerca gregaria (Desert locust). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Orthopteroidea; Orthoptera; Caelifera; Acridomorpha; OC Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca. OX NCBI_TaxID=7010; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97301174; PubMed=9156194; RA Towner P., Harris P., Wolstenholme A.J., Hill C., Worm K., Gartner W.; RT "Primary structure of locust opsins: a speculative model which may RT account for ultraviolet wavelength light detection."; RL Vision Res. 37:495-503(1997). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X80072; CAA56378.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Phosphorylation; KW Glycoprotein; G-protein coupled receptor; Vision. FT DOMAIN 1 51 Extracellular. FT TRANSMEM 52 76 1 (Potential). FT DOMAIN 77 88 Cytoplasmic. FT TRANSMEM 89 115 2 (Potential). FT DOMAIN 116 128 Extracellular. FT TRANSMEM 129 148 3 (Potential). FT DOMAIN 149 166 Cytoplasmic. FT TRANSMEM 167 191 4 (Potential). FT DOMAIN 192 215 Extracellular. FT TRANSMEM 216 243 5 (Potential). FT DOMAIN 244 279 Cytoplasmic. FT TRANSMEM 280 303 6 (Potential). FT DOMAIN 304 311 Extracellular. FT TRANSMEM 312 336 7 (Potential). FT DOMAIN 337 380 Cytoplasmic. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 125 202 Potential. FT BINDING 323 323 Retinal chromophore (By similarity). SQ SEQUENCE 380 AA; 42530 MW; 113504F71027C07A CRC64; MVNTTDFYPV PAAMAYESSV GLPLLGWNVP TEHLDLVHPH WRSFQVPNKY WHFGLAFVYF MLMCMSSLGN GIVLWIYATT KSIRTPSNMF IVNLALFDVL MLLEMPMLVV SSLFYQRPVG WELGCDIYAA LGSVAGIGSA INNAAIAFDR YRTISCPIDG RLTQGQVLAL IAGTWVWTLP FTLMPLLRIW SRFTAEGFLT TCSFDYLTDD EDTKVFVGCI FAWSYAFPLC LICCFYYRLI GAVREHEKML RDQAKKMNVK SLQSNADTEA QSAEIRIAKV ALTIFFLFLC SWTPYAVVAM IGAFGNRAAL TPLSTMIPAV TAKIVSCIDP WVYAINHPRF RAEVQKRMKW LHLGEDARSS KSDTSSTATD RTVGNVSASA // ID OPS3_DROPS STANDARD; PRT; 382 AA. AC P28680; DT 01-DEC-1992 (Rel. 24, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Opsin Rh3 (Inner R7 photoreceptor cells opsin). GN RH3. OS Drosophila pseudoobscura (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7237; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Apple Hill; RX MEDLINE=93012921; PubMed=1398053; RA Carulli J.P., Hartl D.L.; RT "Variable rates of evolution among Drosophila opsin genes."; RL Genetics 132:193-204(1992). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Each Drosophila eye is composed of 800 facets or CC ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), CC the R1 to R6 cells are outer cells, while R7 and R8 are inner CC cells. CC -!- MISCELLANEOUS: Opsin Rh3 is sensitive to UV light. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X65879; CAA46710.1; -. DR PIR; S40693; S40693. DR HSSP; P02699; 1F88. DR FlyBase; FBgn0012709; Dpse\Rh3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Phosphorylation; KW Glycoprotein; G-protein coupled receptor; Vision. FT DOMAIN 1 56 Extracellular. FT TRANSMEM 57 81 1 (Potential). FT DOMAIN 82 93 Cytoplasmic. FT TRANSMEM 94 118 2 (Potential). FT DOMAIN 119 132 Extracellular. FT TRANSMEM 133 152 3 (Potential). FT DOMAIN 153 170 Cytoplasmic. FT TRANSMEM 171 195 4 (Potential). FT DOMAIN 196 219 Extracellular. FT TRANSMEM 220 247 5 (Potential). FT DOMAIN 248 283 Cytoplasmic. FT TRANSMEM 284 307 6 (Potential). FT DOMAIN 308 315 Extracellular. FT TRANSMEM 316 340 7 (Potential). FT DOMAIN 341 382 Cytoplasmic. FT CARBOHYD 12 12 N-linked (GlcNAc...) (Probable). FT DISULFID 129 206 Potential. FT BINDING 327 327 Retinal chromophore. SQ SEQUENCE 382 AA; 42929 MW; AF93922DC0031774 CRC64; MEYHNVSSVL GNVSSVLRPD ARLSAESRLL GWNVPPDELR HIPEHWLIYP EPPESMNYLL GTLYIFFTVI SMIGNGLVMW VFSAAKSLRT PSNILVINLA FCDFMMMIKT PIFIYNSFHQ GYALGHLGCQ IFGVIGSYTG IAAGATNAFI AYDRYNVITR PMEGKMTHGK AIAMIIFIYL YATPWVVACY TESWGRFVPE GYLTSCTFDY LTDNFDTRLF VACIFFFSFV CPTTMITYYY SQIVGHVFSH EKALRDQAKK MNVDSLRSNV DKSKEAAEIR IAKAAITICF LFFASWTPYG VMSLIGAFGD KTLLTPGATM IPACTCKMVA CIDPFVYAIS HPRYRMELQK RCPWLAISEK APESRAAIST STTQEQQQTT AA // ID OPSD_LOLFO STANDARD; PRT; 452 AA. AC P24603; DT 01-MAR-1992 (Rel. 21, Created) DT 01-MAR-1992 (Rel. 21, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Loligo forbesi (Northern European squid). OC Eukaryota; Metazoa; Mollusca; Cephalopoda; Coleoidea; Neocoleoidea; OC Decapodiformes; Loliginidae; Loligo. OX NCBI_TaxID=6618; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=91158727; PubMed=1900420; RA Hall M.D., Hoon M.A., Ryba N.J.P., Pottinger J.D.D., Keen J.N., RA Saibil H.R., Findlay J.B.C.; RT "Molecular cloning and primary structure of squid (Loligo forbesi) RT rhodopsin, a phospholipase C-directed G-protein-linked receptor."; RL Biochem. J. 274:35-40(1991). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This receptor is coupled to the activation CC of phospholipase C. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at 494 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X56788; CAA40108.1; -. DR PIR; S14332; S14332. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR006031; XYPPX. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF02162; XYPPX; 8. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT DOMAIN 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 97 2 (Potential). FT DOMAIN 98 111 Extracellular (Potential). FT TRANSMEM 112 131 3 (Potential). FT DOMAIN 132 151 Cytoplasmic (Potential). FT TRANSMEM 152 175 4 (Potential). FT DOMAIN 176 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 261 Cytoplasmic (Potential). FT TRANSMEM 262 285 6 (Potential). FT DOMAIN 286 294 Extracellular (Potential). FT TRANSMEM 295 318 7 (Potential). FT DOMAIN 319 452 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Probable). FT DISULFID 108 186 By similarity. FT BINDING 305 305 Retinal chromophore (By similarity). FT LIPID 336 336 S-palmitoyl cysteine (By similarity). FT LIPID 337 337 S-palmitoyl cysteine (By similarity). FT DOMAIN 370 380 Met-rich. FT DOMAIN 381 452 Gln/Pro-rich. SQ SEQUENCE 452 AA; 50576 MW; 6AA9E26DE4C4DFA4 CRC64; MGRDIPDNET WWYNPYMDIH PHWKQFDQVP AAVYYSLGIF IAICGIIGCV GNGVVIYLFT KTKSLQTPAN MFIINLAFSD FTFSLVNGFP LMTISCFMKY WVFGNAACKV YGLIGGIFGL MSIMTMTMIS IDRYNVIGRP MSASKKMSHR KAFIMIIFVW IWSTIWAIGP IFGWGAYTLE GVLCNCSFDY ITRDTTTRSN ILCMYIFAFM CPIVVIFFCY FNIVMSVSNH EKEMAAMAKR LNAKELRKAQ AGANAEMKLA KISIVIVTQF LLSWSPYAVV ALLAQFGPIE WVTPYAAQLP VMFAKASAIH NPMIYSVSHP KFRERIASNF PWILTCCQYD EKEIEDDKDA EAEIPAGEQS GGETADAAQM KEMMAMMQKM QAQQQQQPAY PPQGYPPQGY PPPPPQGYPP QGYPPQGYPP QGYPPPPQGP PPQGPPPQAA PPQGVDNQAY QA // ID OPSD_CAMHU STANDARD; PRT; 301 AA. AC O18312; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin (Fragment). GN RHO. OS Cambarus hubrichti (Crayfish). OC Eukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca; OC Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea; OC Astacoidea; Cambaridae; Cambarus. OX NCBI_TaxID=61487; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97336094; PubMed=9192889; RA Crandall K.A., Hillis D.M.; RT "Rhodopsin evolution in the dark."; RL Nature 387:667-668(1997). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF005385; AAB63376.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00578; OPSINLTRLEYE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT NON_TER 1 1 FT DOMAIN <1 18 Extracellular. FT TRANSMEM 19 43 1 (Potential). FT DOMAIN 44 55 Cytoplasmic. FT TRANSMEM 56 80 2 (Potential). FT DOMAIN 81 95 Extracellular. FT TRANSMEM 96 115 3 (Potential). FT DOMAIN 116 134 Cytoplasmic. FT TRANSMEM 135 158 4 (Potential). FT DOMAIN 159 188 Extracellular. FT TRANSMEM 189 210 5 (Potential). FT DOMAIN 211 245 Cytoplasmic. FT TRANSMEM 246 269 6 (Potential). FT DOMAIN 270 279 Extracellular. FT TRANSMEM 280 301 7 (Potential). FT DISULFID 92 169 By similarity. FT BINDING 288 288 Retinal chromophore (By similarity). FT CARBOHYD 165 165 N-linked (GlcNAc...) (Potential). FT NON_TER 301 301 SQ SEQUENCE 301 AA; 34542 MW; 8D456BD50036EC82 CRC64; LHMIHLHWYQ YPPMNPMMYP LLLIFMLFTG ILCLAGNFVT IWVFMNTKSL RTPANLLVVN LAMSDFLMMF TMFPPMMVTC YYHTWTLGPT FCQVYAFLGN LCGCASIWTM VFITFDRYNV IVKGVAGEPL STKKASLWIL SVWVLSTAWC IAPFFGWNHY VPEGNLTGCG TDYLSEDILS RSYLYIYSTW VYFLPLAITI YCYVFIIKAV AAHEKGMRDQ AKKMGIKSLR NEEAQKTSAE CRLAKNAMTT VALWFIAWTP CLLINWVGMF ARSYLSPVYT IWGYVFAKAN AVYNPIVYAI S // ID OPSX_MOUSE STANDARD; PRT; 337 AA. AC O35214; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Visual pigment-like receptor peropsin. GN RRH. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=97420780; PubMed=9275222; RA Sun H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.; RT "Peropsin, a novel visual pigment-like protein located in the apical RT microvilli of the retinal pigment epithelium."; RL Proc. Natl. Acad. Sci. U.S.A. 94:9893-9898(1997). CC -!- FUNCTION: May play a role in rpe physiology either by detecting CC light directly or by monitoring the concentration of retinoids or CC other photoreceptor-derived compounds. CC -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity). CC -!- TISSUE SPECIFICITY: Found only in the eye, where it is localized CC to the retinal pigment epithelium (RPE). In the RPE, it is CC localized to the microvilli that surround the photoreceptor outer CC segments. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF012271; AAC53344.1; -. DR HSSP; P02699; 1BOJ. DR MGD; MGI:1097709; Rrh. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR01244; PEROPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 26 Extracellular. FT TRANSMEM 27 49 1 (Potential). FT DOMAIN 50 61 Cytoplasmic. FT TRANSMEM 62 87 2 (Potential). FT DOMAIN 88 101 Extracellular. FT TRANSMEM 102 121 3 (Potential). FT DOMAIN 122 140 Cytoplasmic. FT TRANSMEM 141 164 4 (Potential). FT DOMAIN 165 188 Extracellular. FT TRANSMEM 189 212 5 (Potential). FT DOMAIN 213 240 Cytoplasmic. FT TRANSMEM 241 264 6 (Potential). FT DOMAIN 265 272 Extracellular. FT TRANSMEM 273 297 7 (Potential). FT DOMAIN 298 337 Cytoplasmic. FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 182 182 N-linked (GlcNAc...) (Potential). FT DISULFID 98 175 Potential. FT BINDING 284 284 Retinal chromophore. SQ SEQUENCE 337 AA; 37208 MW; 353E4E2278EDBFA6 CRC64; MLSEASDFNS SGSRSEGSVF SRTEHSVIAA YLIVAGITSI LSNVVVLGIF IKYKELRTPT NAVIINLAFT DIGVSSIGYP MSAASDLHGS WKFGHAGCQI YAGLNIFFGM VSIGLLTVVA MDRYLTISCP DVGRRMTTNT YLSMILGAWI NGLFWALMPI IGWASYAPDP TGATCTINWR NNDTSFVSYT MMVIVVNFIV PLTVMFYCYY HVSRSLRLYA ASDCTAHLHR DWADQADVTK MSVIMILMFL LAWSPYSIVC LWACFGNPKK IPPSMAIIAP LFAKSSTFYN PCIYVAAHKK FRKAMLAMFK CQPHLAVPEP STLPMDMPQS SLAPVRI // ID RGR_MOUSE STANDARD; PRT; 291 AA. AC Q9Z2B3; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE RPE-retinal G protein-coupled receptor. GN RGR. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=99059917; PubMed=9841934; RA Tao L., Shen D., Pandey S., Hao W., Rich K.A., Fong H.K.W.; RT "Structure and developmental expression of the mouse RGR opsin gene."; RL Mol. Vision 4:25-25(1998). CC -!- FUNCTION: Receptor for all-trans-and 11-cis-retinal. Binds CC preferentially to the former and may catalyze the isomerization of CC the chromophore by a retinochrome-like mechanism (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Covalently binds all-trans- and 11-cis-retinal (By CC similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF076930; AAC69836.1; -. DR MGD; MGI:1929473; Rgr. DR GO; GO:0005887; C:integral to plasma membrane; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS00238; OPSIN; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Retinal protein; Vision. FT DOMAIN 1 15 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 16 36 1 (POTENTIAL). FT DOMAIN 37 52 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 53 73 2 (POTENTIAL). FT DOMAIN 74 91 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 92 112 3 (POTENTIAL). FT DOMAIN 113 130 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 131 151 4 (POTENTIAL). FT DOMAIN 152 175 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 176 196 5 (POTENTIAL). FT DOMAIN 197 219 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 220 240 6 (POTENTIAL). FT DOMAIN 241 247 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 248 268 7 (POTENTIAL). FT DOMAIN 269 291 CYTOPLASMIC (POTENTIAL). FT DISULFID 88 162 POTENTIAL. FT BINDING 255 255 RETINAL CHROMOPHORE (BY SIMILARITY). SQ SEQUENCE 291 AA; 32126 MW; ED31E1F937810A7B CRC64; MAATRALPAG LGELEVLAVG TVLLMEALSG ISLNGLTIFS FCKTPDLRTP SNLLVLSLAL ADTGISLNAL VAAVSSLLRR WPHGSEGCQV HGFQGFATAL ASICGSAAVA WGRYHHYCTR RQLAWDTAIP LVLFVWMSSA FWASLPLMGW GHYDYEPVGT CCTLDYSRGD RNFISFLFTM AFFNFLVPLF ITHTSYRFME QKFSRSGHLP VNTTLPGRML LLGWGPYALL YLYAAIADVS FISPKLQMVP ALIAKTMPTI NAINYALHRE MVCRGTWQCL SPQKSKKDRT Q // ID OR09_MOUSE STANDARD; PRT; 310 AA. AC Q8VGS3; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 180-1. GN MOR180-1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073073; AAL60736.1; -. DR EMBL; AY318214; AAP71469.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 26 46 1 (POTENTIAL). FT DOMAIN 47 54 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 55 75 2 (POTENTIAL). FT DOMAIN 76 99 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 100 120 3 (POTENTIAL). FT DOMAIN 121 133 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 134 154 4 (POTENTIAL). FT DOMAIN 155 196 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 197 217 5 (POTENTIAL). FT DOMAIN 218 237 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 238 258 6 (POTENTIAL). FT DOMAIN 259 271 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 272 292 7 (POTENTIAL). FT DOMAIN 293 310 CYTOPLASMIC (POTENTIAL). FT DISULFID 97 189 BY SIMILARITY. FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 310 AA; 34860 MW; 27F64FBDCA3AA41A CRC64; MDKENHSVVT EFVFMGITQD PQLQIIFFVV FLLVYLVNVI GNVGMIILII TDSQLHTPMY FFLCNLSFVD LGYSSAIAPR MLADFLTKHK VISFSSCATQ FAFFVGFVDA ECYVLAAMAY DRFVAICRPL HYSTLMSKKV CLVLMLGSYF AGLVSLVAHT SLTFSLSYCG SNIINHFFCE IPPLLALSCS DTYISEILLF SLCGFIEFST ILIIFISYAF ILIAIIRIRS AEGRLKAFST CGSHLTGVTL FYGTVMFMYL RPTSSYSLDQ DKWASVFYTI IIPMLNPLIY SLRNKDVKAA FKKLIGKKPQ // ID OR31_MOUSE STANDARD; PRT; 321 AA. AC Q8VFD3; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 204-16. GN MOR204-16. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073598; AAL61261.1; -. DR EMBL; AY317592; AAP70988.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 49 1 (POTENTIAL). FT DOMAIN 50 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 78 2 (POTENTIAL). FT DOMAIN 79 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 123 3 (POTENTIAL). FT DOMAIN 124 136 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 137 157 4 (POTENTIAL). FT DOMAIN 158 199 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 200 220 5 (POTENTIAL). FT DOMAIN 221 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 261 6 (POTENTIAL). FT DOMAIN 262 274 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 275 295 7 (POTENTIAL). FT DOMAIN 296 321 CYTOPLASMIC (POTENTIAL). FT DISULFID 100 192 BY SIMILARITY. FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 321 AA; 35724 MW; 262CDEA4EEBA8A46 CRC64; MAFLHNGNHT AVTEFILLGL TDDPVLRIVL FTIILCIYLV TVSGNLSTIL LIRVSSQLHH PMYFFLSHLA SADIGYSSSV TPNMLVNFLV KQNTISYIGC SIQFGSAAFF GGLECFLLAV MAYDRFVAIC NPLLYSTKMS TQVCVQLVVG SYIGGFLNAS FATVSFLFLF FCGPNIINHF FCDFAPLIEL SCSDVRISVL VTSFSAGTVT MLTVLVIAIS YTYILITILK MRSTEGRHKA FSTCTSHLTA VSLFYGTITF IYVMPKSRYS TDQNKVVSVF YMVVIPMLNP LIYSLRNNEI KGALRRHLGK KIFSQSNILF Y // ID OR29_MOUSE STANDARD; PRT; 323 AA. AC Q8VG03; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 204-14. GN MOR204-14. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073362; AAL61025.1; -. DR EMBL; AY317590; AAP70986.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 49 1 (POTENTIAL). FT DOMAIN 50 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 78 2 (POTENTIAL). FT DOMAIN 79 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 123 3 (POTENTIAL). FT DOMAIN 124 136 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 137 157 4 (POTENTIAL). FT DOMAIN 158 199 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 200 220 5 (POTENTIAL). FT DOMAIN 221 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 261 6 (POTENTIAL). FT DOMAIN 262 274 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 275 295 7 (POTENTIAL). FT DOMAIN 296 323 CYTOPLASMIC (POTENTIAL). FT DISULFID 100 192 BY SIMILARITY. FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 92 92 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 268 268 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 323 AA; 35699 MW; 516CBE62BD6BF07C CRC64; MAFLEDGNHT AVTEFILVGL TDDPVLKVIL FTIILCIYLV TVSGNLSTIL LIRVSSQLHH PMYFFLSHLA SVDLGYSSSV TPNMLINFLA ENNTISYIGC SIQFGSATFF GVLECFLLAV MAYDRFVAIC NPLLYSIKMS TQVCVKLVVG SYIGSSLNAS FVTVSIFNLL FCGPNKINHF FCDFDPLIEL SCSDVSVPVA VTSCSAGLIT MITVFVIAVS YTYILITVLK MRSTEGRHKA FSTCTSHLTA VTLFYGTVTF IYVMPKSNYS TDQNKVVSVF YMVVIPMLNP LIYSLRNNEI KGALKRQLGK KIFSQSNILF CKS // ID O8B8_HUMAN STANDARD; PRT; 311 AA. AC Q15620; Q96RC8; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8B8 (Olfactory receptor TPCR85) (Olfactory-like DE receptor JCG8). GN OR8B8. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Tongue; RX MEDLINE=21562400; PubMed=11705801; RA Gaudin J.-C., Breuils L., Haertle T.; RT "New GPCRs from a human lingual cDNA library."; RL Chem. Senses 26:1157-1166(2001). RN [2] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE OF 68-283 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [4] RP SEQUENCE OF 126-282 FROM N.A. RC TISSUE=Testis; RX MEDLINE=97224452; PubMed=9119360; RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.; RT "Specific repertoire of olfactory receptor genes in the male germ RT cells of several mammalian species."; RL Genomics 39:239-246(1997). CC -!- FUNCTION: Putative odorant receptor. Could also be involved in CC taste perception. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in the tongue and testis. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8B8". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF238488; AAL32997.1; -. DR EMBL; AB065832; BAC06051.1; -. DR EMBL; AF399510; AAK94995.1; -. DR EMBL; X89675; CAA61822.1; -. DR PIR; S58007; S58007. DR Genew; HGNC:8477; OR8B8. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004984; F:olfactory receptor activity; NAS. DR GO; GO:0007608; P:perception of smell; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 311 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CONFLICT 204 204 G -> S (in Ref. 4). SQ SEQUENCE 311 AA; 34482 MW; 9D8AAC4DA179ABE6 CRC64; MAAENSSFVT QFILAGLTDQ PGVQIPLFFL FLGFYVVTVV GNLGLITLIR LNSHLHTPMY FFLYNLSFID FCYSSVITPK MLMSFVLKKN SISYAGCMTQ LFFFLFFVVS ESFILSAMAY DRYVAICNPL LYMVTMSPQV CFLLLLGVYG MGFAGAMAHT ACMMGVTFCA NNLVNHYMCD ILPLLECACT STYVNELVVF VVVGIDIGVP TVTIFISYAL ILSSIFHIDS TEGRSKAFST CSSHIIAVSL FFGSGAFMYL KPFSLLAMNQ GKVSSLFYTT VVPMLNPLIY SLRNKDVKVA LKKILNKNAF S // ID OLF5_RAT STANDARD; PRT; 313 AA. AC P23266; DT 01-NOV-1991 (Rel. 20, Created) DT 01-NOV-1991 (Rel. 20, Last sequence update) DT 01-JUL-1993 (Rel. 26, Last annotation update) DE Olfactory receptor-like protein F5. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91191556; PubMed=1840504; RA Buck L., Axel R.; RT "A novel multigene family may encode odorant receptors: a molecular RT basis for odor recognition."; RL Cell 65:175-187(1991). CC -!- FUNCTION: PUTATIVE ODORANT RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: OLFACTORY EPITHELIUM. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M64377; AAA41740.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 26 50 1 (POTENTIAL). FT DOMAIN 51 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 79 2 (POTENTIAL). FT DOMAIN 80 100 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 101 120 3 (POTENTIAL). FT DOMAIN 121 139 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 140 158 4 (POTENTIAL). FT DOMAIN 159 196 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 197 219 5 (POTENTIAL). FT DOMAIN 220 236 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 237 260 6 (POTENTIAL). FT DOMAIN 261 272 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 273 292 7 (POTENTIAL). FT DOMAIN 293 313 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 97 189 BY SIMILARITY. SQ SEQUENCE 313 AA; 34703 MW; 2FD7BCD6E36D8815 CRC64; MSSTNQSSVT EFLLLGLSRQ PQQQQLLFLL FLIMYLATVL GNLLIILAIG TDSRLHTPMY FFLSNLSFVD VCFSSTTVPK VLANHILGSQ AISFSGCLTQ LYFLAVFGNM DNFLLAVMSY DRFVAICHPL HYTTKMTRQL CVLLVVGSWV VANMNCLLHI LLMARLSFCA DNMIPHFFCD GTPLLKLSCS DTHLNELMIL TEGAVVMVTP FVCILISYIH ITCAVLRVSS PRGGWKSFST CGSHLAVVCL FYGTVIAVYF NPSSSHLAGR DMAAAVMYAV VTPMLNPFIY SLRNSDMKAA LRKVLAMRFP SKQ // ID O5J2_HUMAN STANDARD; PRT; 312 AA. AC Q8NH18; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 5J2. GN OR5J2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5J2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065595; BAC05823.1; -. DR Genew; HGNC:19612; OR5J2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 196 Extracellular (Potential). FT TRANSMEM 197 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 312 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 312 AA; 34808 MW; F21D7E3DB3D02B70 CRC64; MADDNFTVVT EFILLGLTDH AELKAVLFVV FLVIYAITLL RNLGMILLIQ ITSKLHTPMY FLLSCLSFVD ACYSSAIAPK MLVNLLVVKA TISFSACMVQ HLCFGVFITT EGFLLSVMAY DRYVAIVSPL LYTVAMSDRK CVELVTGSWI GGIVNTLIHT ISLRRLSFCR LNAVSHFFCD IPSLLKLSCS DTSMNELLLL TFSGVIAMAT FLTVIISYIF IAFASLRIHS ASGRQQAFST CASHLTAVTI FYGTLIFSYI QPSSQYFVEQ EKVVSMFYTL GIPMLNLLIH SLRNKDVKEA VKRAIEMKHF LC // ID O2B2_HUMAN STANDARD; PRT; 357 AA. AC Q9GZK3; Q9GZL2; Q9Y299; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). GN OR2B2 OR OR2B9. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A., AND VARIANT ARG-234. RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., RA Volz A., Younger R., Beck S.; RT "Polymorphic olfactory receptor genes and HLA loci constitute extended RT haplotypes."; RL (In) Kasahara M. (eds.); RL Major histocompatibility complex-evolution, structure, and function, RL pp.110-130, Springer-Verlag, Tokyo (2000). RN [2] RP SEQUENCE OF 1-310 FROM N.A. RA Wild A.; RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2B2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AJ302584; CAC20504.1; -. DR EMBL; AJ302585; CAC20505.1; -. DR EMBL; AJ302586; CAC20506.1; -. DR EMBL; AJ302587; CAC20507.1; -. DR EMBL; AJ302588; CAC20508.1; -. DR EMBL; AJ302589; CAC20509.1; -. DR EMBL; AJ302590; CAC20510.1; -. DR EMBL; AJ302591; CAC20511.1; -. DR EMBL; AJ302592; CAC20512.1; -. DR EMBL; AJ302593; CAC20513.1; -. DR EMBL; Z98744; CAD24079.1; -. DR Genew; HGNC:13966; OR2B2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction; Polymorphism. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 292 7 (Potential). FT DOMAIN 293 357 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT VARIANT 234 234 Q -> R (in allele 6M1-10*02). FT /FTId=VAR_010943. SQ SEQUENCE 357 AA; 40412 MW; 53E2F82820EC440A CRC64; MNWVNKSVPQ EFILLVFSDQ PWLEIPPFVM FLFSYILTIF GNLTIILVSH VDFKLHTPMY FFLSNLSLLD LCYTTSTVPQ MLVNICNTRK VISYGGCVAQ LFIFLALGST ECLLLAVMCF DRFVAICRPL HYSIIMHQRL CFQLAAASWI SGFSNSVLQS TWTLKMPLCG HKEVDHFFCE VPALLKLSCV DTTANEAELF FISVLFLLIP VTLILISYAF IVQAVLRIQS AEGQRKAFGT CGSHLIVVSL FYGTAISMYL QPPSPSSKDR GKMVSLFCGI IAPMLNPLIY TLRNKEVKEA FKRLVAKSLL NQEIRNMQMI SFAKDTVLTY LTNFSASCPI FVITIENYCN LPQRKFP // ID O2G3_HUMAN STANDARD; PRT; 309 AA. AC Q8NGZ4; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 2G3. GN OR2G3. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2G3". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065622; BAC05848.1; -. DR Genew; HGNC:15008; OR2G3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 292 7 (Potential). FT DOMAIN 293 309 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 309 AA; 34506 MW; F72A80E3A753695C CRC64; MGLGNESSLM DFILLGFSDH PRLEAVLFVF VLFFYLLTLV GNFTIIIISY LDPPLHTPMY FFLSNLSLLD ICFTTSLAPQ TLVNLQRPKK TITYGGCVAQ LYISLALGST ECILLADMAL DRYIAVCKPL HYVVIMNPRL CQQLASISWL SGLASSLIHA TFTLQLPLCG NHRLDHFICE VPALLKLACV DTTVNELVLF VVSVLFVVIP PALISISYGF ITQAVLRIKS VEARHKAFST CSSHLTVVII FYGTIIYVYL QPSDSYAQDQ GKFISLFYTM VTPTLNPIIY TLRNKDMKEA LRKLLSGKL // ID O9I1_HUMAN STANDARD; PRT; 314 AA. AC Q8NGQ6; Q96RA8; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 9I1. GN OR9I1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-283 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR9I1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065733; BAC05954.1; -. DR EMBL; AF399531; AAK95016.1; -. DR Genew; HGNC:14718; OR9I1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 314 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 314 AA; 34907 MW; BCB7E6BC6ADA706A CRC64; MAKNNLTRVT EFILMGFMDH PKLEIPLFLV FLSFYLVTLL GNVGMIMLIQ VDVKLYTPMY FFLSHLSLLD ACYTSVITPQ ILATLATGKT VISYGHCAAQ FFLFTICAGT ECFLLAVMAY DRYAAIRNPL LYTVAMNPRL CWSLVVGAYV CGVSGAILRT TCTFTLSFCK DNQINFFFCD LPPLLKLACS DTANIEIVII FFGNFVILAN ASVILISYLL IIKTILKVKS SGGRAKTFST CASHITAVAL FFGALIFMYL QSGSGKSLEE DKVVSVFYTV VIPMLNPLIY SLRNKDVKDA FRKVARRLQV SLSM // ID OR41_MOUSE STANDARD; PRT; 330 AA. AC Q8VEW2; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 204-36. GN MOR204-36. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073786; AAL61449.1; -. DR EMBL; AY317606; AAP71000.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 49 1 (POTENTIAL). FT DOMAIN 50 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 78 2 (POTENTIAL). FT DOMAIN 79 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 123 3 (POTENTIAL). FT DOMAIN 124 136 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 137 157 4 (POTENTIAL). FT DOMAIN 158 199 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 200 220 5 (POTENTIAL). FT DOMAIN 221 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 261 6 (POTENTIAL). FT DOMAIN 262 274 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 275 295 7 (POTENTIAL). FT DOMAIN 296 330 CYTOPLASMIC (POTENTIAL). FT DISULFID 100 192 BY SIMILARITY. FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). FT CONFLICT 16 16 I -> F (IN REF. 2). SQ SEQUENCE 330 AA; 36854 MW; 8C60A83B91046083 CRC64; MAFLEDGNHT TVTEFILLGL TDDPVLRDIL FIIILCIYLV TVSGNLSTIL LIRVSSQLHH PMYFILSHLA SVDIGISSSV TPNMLATFLV KQNTISYIGC SIQFTSAAFF GTVECFLLAT MAYDRFVAIC NPLLYSTKMS TEACIQLVVG SYIQGFLNAS FFTLSFFSLF FCGPNRINDF YCDFAPLLEL SCSDVTVAVV ITSISAGFIT LTTVFVIAIS YSCIFITIMK MHSTESRCKA FSTCTSHLTA VILFYGTAIF IYVMPKSSYS TDQNKVLSIF YTVVIPMLNP LIYSLRNNEI KEALKRHLGK KVFSYGNLFC KTHYNHNYPV // ID O1G1_PANTR STANDARD; PRT; 313 AA. AC Q9TU99; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 1G1. GN OR1G1. OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99443869; PubMed=10512677; RA Sharon D., Glusman G., Pilpel Y., Khen M., Gruetzner F., Haaf T., RA Lancet D.; RT "Primate evolution of an olfactory receptor cluster: diversification RT by gene conversion and recent emergence of pseudogenes."; RL Genomics 61:24-36(1999). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF101744; AAF03325.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 140 Cytoplasmic (Potential). FT TRANSMEM 141 158 4 (Potential). FT DOMAIN 159 196 Extracellular (Potential). FT TRANSMEM 197 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 292 7 (Potential). FT DOMAIN 293 313 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 313 AA; 35052 MW; 39D12C7959BEFCB3 CRC64; MEGKNLTSIS EFFLLGFSEQ LEEQKALFGS FLFMYLVMVA GNLLIILVII TDTQLHTPMY FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ LYFFMLFVML EAFLLAVMAY DHYVAICHPL HYILIMSPGL CVFLVSASWI MNALYSLLHT LLMNSLSFCA NHEIPHFFCD IDPLLSLSCA DPFTNELVIF ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST CSSHLSVVSL FXGTSFCVYF SPPSTRXAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS LRKLIWVRKI HSP // ID OR34_MOUSE STANDARD; PRT; 314 AA. AC Q8VFD0; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 204-19. GN MOR204-19. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073601; AAL61264.1; -. DR EMBL; AY317594; AAP70990.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 49 1 (POTENTIAL). FT DOMAIN 50 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 78 2 (POTENTIAL). FT DOMAIN 79 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 123 3 (POTENTIAL). FT DOMAIN 124 136 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 137 157 4 (POTENTIAL). FT DOMAIN 158 199 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 200 220 5 (POTENTIAL). FT DOMAIN 221 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 261 6 (POTENTIAL). FT DOMAIN 262 274 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 275 295 7 (POTENTIAL). FT DOMAIN 296 314 CYTOPLASMIC (POTENTIAL). FT DISULFID 100 192 BY SIMILARITY. FT CARBOHYD 6 6 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 314 AA; 35206 MW; 003235CDF6D6BA7D CRC64; MAFIYNGSQT TVTEFILLGL TDDPVLKVIL FCIILCIYLV TVFGNLSTIL LIGVSSKLHH PMYFFLSHLA SVDMGLSSSV TPNMLVNFLT EKNTISYLGC GIQLSSAAFF GAVEFFLLAA MAYDRLVAIC NPLLYSTKMS SQVCIQLVAG SYVGGFLNAS FVTHFFFSFL FCGPNRVNHF FCDLSPMMEL SCSDVSISEI VISFSAGSFT MTTLFVIVIP YFYIFITILK IRSTEGRQKA FSTCTSHLTA VTLYYGTIIF IYVMPKSTYS RDQNKVVSLF YMLVIPVLNP LIYSLRNNEI KDALKRQFYR KTLL // ID OR16_MOUSE STANDARD; PRT; 310 AA. AC Q8VGI6; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 204-1. GN MOR204-1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073162; AAL60825.1; -. DR EMBL; AY317585; AAP70981.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 26 46 1 (POTENTIAL). FT DOMAIN 47 54 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 55 75 2 (POTENTIAL). FT DOMAIN 76 99 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 100 120 3 (POTENTIAL). FT DOMAIN 121 133 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 134 154 4 (POTENTIAL). FT DOMAIN 155 196 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 197 217 5 (POTENTIAL). FT DOMAIN 218 237 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 238 258 6 (POTENTIAL). FT DOMAIN 259 271 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 272 292 7 (POTENTIAL). FT DOMAIN 293 310 CYTOPLASMIC (POTENTIAL). FT DISULFID 97 189 BY SIMILARITY. FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 20 20 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 265 265 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 310 AA; 34140 MW; 5989CD56DF98E880 CRC64; MEAQNHTTVK EFILLGLTEN STLRVILFMI FLGIYTVTLV GNFSIISLIR SCPQLHTPMY LFLSHLALVD IGFSTSITPI MLTGFLGHTV TLSVAACVAQ FCIAVTFGTV ECFLLAVMAY DRYVAICSPL LYSTHMSPRI CFLLVGASYV GGCVNSGTFT SCLLILSFCG PNQIDHFFCD FPAVLKLSCS DVSIIGIIPS ISAGSIIVIT VFVIAVSYTY ILITILNMRS TEGRHKAFST CTSHLTAVTL YYGTITFIYV MPKSNYSTAQ NKILSVFYTV VIPMLNPLIY SLRNRDVKEA LRKAIIRIFP // ID O2AC_HUMAN STANDARD; PRT; 310 AA. AC Q8NGT7; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 2A12. GN OR2A12. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2A12". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065694; BAC05917.1; -. DR Genew; HGNC:15082; OR2A12. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 24 Extracellular (Potential). FT TRANSMEM 25 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 78 2 (Potential). FT DOMAIN 79 99 Extracellular (Potential). FT TRANSMEM 100 119 3 (Potential). FT DOMAIN 120 138 Cytoplasmic (Potential). FT TRANSMEM 139 157 4 (Potential). FT DOMAIN 158 194 Extracellular (Potential). FT TRANSMEM 195 218 5 (Potential). FT DOMAIN 219 235 Cytoplasmic (Potential). FT TRANSMEM 236 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 291 7 (Potential). FT DOMAIN 292 310 Cytoplasmic (Potential). FT DISULFID 96 188 By similarity. FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 310 AA; 35213 MW; 5A25409ADB5BC857 CRC64; MESNQTWITE VILLGFQVDP ALELFLFGFF LLFYSLTLMG NGIILGLIYL DSRLHTPMYV FLSHLAIVDM SYASSTVPKM LANLVMHKKV ISFAPCILQT FLYLAFAITE CLILVMMCYD RYVAICHPLQ YTLIMNWRVC TVLASTCWIF SFLLALVHIT LILRLPFCGP QKINHFFCQI MSVFKLACAD TRLNQVVLFA GSAFILVGPL CLVLVSYLHI LVAILRIQSG EGRRKAFSTC SSHLCVVGLF FGSAIVMYMA PKSSHSQERR KILSLFYSLF NPILNPLIYS LRNAEVKGAL KRVLWKQRSM // ID OAC1_HUMAN STANDARD; PRT; 312 AA. AC Q96KK4; Q96R18; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 10C1 (Hs6M1-17). GN OR10C1 OR OR10C2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Whitaker H.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 67-282 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10C2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AL035542; CAB44507.1; ALT_INIT. DR EMBL; AF399627; AAK95112.1; -. DR Genew; HGNC:8165; OR10C1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 24 Extracellular (Potential). FT TRANSMEM 25 45 1 (Potential). FT DOMAIN 46 53 Cytoplasmic (Potential). FT TRANSMEM 54 74 2 (Potential). FT DOMAIN 75 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT DOMAIN 120 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT DOMAIN 160 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT DOMAIN 217 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT DOMAIN 292 312 Cytoplasmic (Potential). FT DISULFID 96 188 By similarity. FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 312 AA; 34351 MW; B6FD6E0E700CB2CC CRC64; MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST DAALQSPMYF FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM FFFLFFGATE CCLLAAMAYD RYAAICEPLR YPLLLSHRVC LQLAGSAWAC GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI QPVLQLVCGD TSLNELQIIL ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC SSHLIVVSLF YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL KRTIQKTVPM EI // ID O5M1_HUMAN STANDARD; PRT; 315 AA. AC Q8NGP8; Q96RB6; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 5M1 (OST050). GN OR5M1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-283 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5M1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065742; BAC05962.1; -. DR EMBL; AF399522; AAK95007.1; -. DR Genew; HGNC:8352; OR5M1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 196 Extracellular (Potential). FT TRANSMEM 197 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 315 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 315 AA; 35608 MW; 6EB3D61F84884E56 CRC64; MFSPNHTIVT EFILLGLTDD PVLEKILFGV FLAIYLITLA GNLCMILLIR TNSHLQTPMY FFLGHLSFVD ICYSSNVTPN MLHNFLSEQK TISYAGCFTQ CLLFIALVIT EFYILASMAL DRYVAICSPL HYSSRMSKNI CVCLVTIPYM YGFLSGFSQS LLTFHLSFCG SLEINHFYCA DPPLIMLACS DTRVKKMAMF VVAGFNLSSS LFIILLSYLF IFAAIFRIRS AEGRHKAFST CASHLTIVTL FYGTLFCMYV RPPSEKSVEE SKITAVFYTF LSPMLNPLIY SLRNTDVILA MQQMIRGKSF HKIAV // ID OLF3_CHICK STANDARD; PRT; 318 AA. AC P37069; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE Olfactory receptor-like protein COR3. GN COR3. OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Olfactory epithelium; RX MEDLINE=96317247; PubMed=8734500; RA Nef S., Allaman I., Fiumelli H., de Castro E., Nef P.; RT "Olfaction in birds: differential embryonic expression of nine RT putative odorant receptor genes in the avian olfactory system."; RL Mech. Dev. 55:65-77(1996). CC -!- FUNCTION: PUTATIVE ODORANT RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Z79585; CAB01846.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Olfaction; Multigene family. FT DOMAIN 1 26 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 27 49 1 (POTENTIAL). FT DOMAIN 50 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 79 2 (POTENTIAL). FT DOMAIN 80 100 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 101 120 3 (POTENTIAL). FT DOMAIN 121 139 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 140 164 4 (POTENTIAL). FT DOMAIN 165 205 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 206 226 5 (POTENTIAL). FT DOMAIN 227 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 260 6 (POTENTIAL). FT DOMAIN 261 271 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 272 292 7 (POTENTIAL). FT DOMAIN 293 318 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 97 179 BY SIMILARITY. SQ SEQUENCE 318 AA; 35757 MW; D50C72EBA043A962 CRC64; MASGNCTTPT TFILSGLTDN PGLQMPLFMV FLAIYTITLL TNLGLIRLIS VDLHLQTPMY IFLQNLSFTD AAYSTVITPK MLATFLEERK TISYVGCILQ YFSFVLLTTS ECLLLAVMAY DRYVAICKPL LYPAIMTKAV CWRLVESLYF LAFLNSLVHT CGLLKLSFCY SNVVNHFFCD ISPLFQISSS SIAISELLVI ISGSLFVMSS IIIILISYVF IILTVVMIRS KDGKYKAFST CTSHLMAVSL FHGTVIFMYL RPVKLFSLDT DKIASLFYTV VIPMLNPLIY SWRNKEVKDA LRRLTATTFG FIDSKAVQ // ID O5M8_HUMAN STANDARD; PRT; 311 AA. AC Q8NGP6; Q96RB8; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 5M8. GN OR5M8. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 67-282 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5M8". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065744; BAC05964.1; -. DR EMBL; AF399520; AAK95005.1; -. DR Genew; HGNC:14846; OR5M8. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 24 Extracellular (Potential). FT TRANSMEM 25 45 1 (Potential). FT DOMAIN 46 53 Cytoplasmic (Potential). FT TRANSMEM 54 74 2 (Potential). FT DOMAIN 75 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT DOMAIN 120 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT DOMAIN 160 195 Extracellular (Potential). FT TRANSMEM 196 216 5 (Potential). FT DOMAIN 217 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT DOMAIN 292 311 Cytoplasmic (Potential). FT DISULFID 96 188 By similarity. FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 311 AA; 35602 MW; 9C7E33E15CC97F59 CRC64; MRRNCTLVTE FILLGLTSRR ELQILLFTLF LAIYMVTVAG NLGMIVLIQA NAWLHMPMYF FLSHLSFVDL CFSSNVTPKM LEIFLSEKKS ISYPACLVQC YLFIALVHVE IYILAVMAFD RYMAICNPLL YGSRMSKSVC SFLITVPYVY GALTGLMETM WTYNLAFCGP NEINHFYCAD PPLIKLACSD TYNKELSMFI VAGWNLSFSL FIICISYLYI FPAILKIRST EGRQKAFSTC GSHLTAVTIF YATLFFMYLR PPSKESVEQG KMVAVFYTTV IPMLNLIIYS LRNKNVKEAL IKELSMKIYF S // ID O8K1_HUMAN STANDARD; PRT; 319 AA. AC Q8NGG5; Q96RC1; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8K1. GN OR8K1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 74-289 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8K1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065835; BAC06054.1; -. DR EMBL; AF399517; AAK95002.1; -. DR Genew; HGNC:14831; OR8K1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 31 Extracellular (Potential). FT TRANSMEM 32 52 1 (Potential). FT DOMAIN 53 60 Cytoplasmic (Potential). FT TRANSMEM 61 81 2 (Potential). FT DOMAIN 82 105 Extracellular (Potential). FT TRANSMEM 106 126 3 (Potential). FT DOMAIN 127 145 Cytoplasmic (Potential). FT TRANSMEM 146 166 4 (Potential). FT DOMAIN 167 203 Extracellular (Potential). FT TRANSMEM 204 223 5 (Potential). FT DOMAIN 224 243 Cytoplasmic (Potential). FT TRANSMEM 244 264 6 (Potential). FT DOMAIN 265 277 Extracellular (Potential). FT TRANSMEM 278 298 7 (Potential). FT DOMAIN 299 319 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 319 AA; 36581 MW; 9CB4F7F94917E9D5 CRC64; MNHVVKHNHT AVTKVTEFIL MGITDNPGLQ APLFGLFLII YLVTVIGNLG MVILTYLDSK LHTPMYFFLR HLSITDLGYS TVIAPKMLVN FIVHKNTISY NWYATQLAFF EIFIISELFI LSAMAYDRYV AICKPLLYVI IMAEKVLWVL VIVPYLYSTF VSLFLTIKLF KLSFCGSNII SYFYCDCIPL MSILCSDTNE LELIILIFSG CNLLFSLSIV LISYMFILVA ILRMNSRKGR YKAFSTCSSH LTVVIMFYGT LLFIYLQPKS SHTLAIDKMA SVFYTLLIPM LNPLIYSLRN KEVKDALKRT LTNRFKIPI // ID O8K3_HUMAN STANDARD; PRT; 312 AA. AC Q8NH51; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8K3. GN OR8K3. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8K3". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065541; BAC05786.1; -. DR Genew; HGNC:15313; OR8K3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT DOMAIN 292 312 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 312 AA; 35462 MW; ED061A5992DB4212 CRC64; MEQHNLTTVN EFILTGITDI AELQAPLFAL FLMIYVISVM GNLGMIVLTK LDSRLQTPMY FFLRHLAFMD LGYSTTVGPK MLVNFVVDKN IISYYFCATQ LAFFLVFIGS ELFILSAMSY DLYVAICNPL LYTVIMSRRV CQVLVAIPYL YCTFISLLVT IKIFTLSFCG YNVISHFYCD SLPLLPLLCS NTHEIELIIL IFAAIDLISS LLIVLLSYLL ILVAILRMNS AGRQKAFSTC GAHLTVVIVF YGTLLFMYVQ PKSSHSFDTD KVASIFYTLV IPMLNPLIYS LRNKDVKYAL RRTWNNLCNI FV // ID OLF6_CHICK STANDARD; PRT; 312 AA. AC P37072; Q98912; DT 01-JUN-1994 (Rel. 29, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE Olfactory receptor-like protein COR6. GN COR6. OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Olfactory epithelium; RX MEDLINE=96317247; PubMed=8734500; RA Nef S., Allaman I., Fiumelli H., de Castro E., Nef P.; RT "Olfaction in birds: differential embryonic expression of nine RT putative odorant receptor genes in the avian olfactory system."; RL Mech. Dev. 55:65-77(1996). CC -!- FUNCTION: PUTATIVE ODORANT RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Z79590; CAB01851.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Olfaction; Multigene family. FT DOMAIN 1 26 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 27 49 1 (POTENTIAL). FT DOMAIN 50 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 79 2 (POTENTIAL). FT DOMAIN 80 100 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 101 120 3 (POTENTIAL). FT DOMAIN 121 139 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 140 164 4 (POTENTIAL). FT DOMAIN 165 205 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 206 226 5 (POTENTIAL). FT DOMAIN 227 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 260 6 (POTENTIAL). FT DOMAIN 261 271 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 272 292 7 (POTENTIAL). FT DOMAIN 293 312 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 97 179 BY SIMILARITY. SQ SEQUENCE 312 AA; 35179 MW; 56D164BF99D59EA9 CRC64; MASGNCTTPT TFILSGLTDN PGLQMPLFMV FLAIYTITLL TNLGLIALIS IDLQLQTPMY IFLQNLSFTD AVYSTVITPK MLATFLEETK TISYVGCILQ YFSFVLLTVR ECLLLAVMAY DRYAAICKPL LYPAIMTKAV CWRLVKGLYS LAFLNFLVHT SGLLKLSFCS SNVVNHFFCD NSPLFQISSS STALNELLVF IFGSLFVMSS IITILISYVF IILTVVRIRS KERKYKAFST CTSHLMAVSL FHGTIVFMYF QPANNFSLDK DKIMSLFYTV VIPMLNPLIY SWRNKEVKDA LHRAIATAVL FH // ID O5AN_HUMAN STANDARD; PRT; 311 AA. AC Q8NGI8; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 5AN1. GN OR5AN1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5AN1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065806; BAC06025.1; -. DR Genew; HGNC:15255; OR5AN1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 26 Extracellular (Potential). FT TRANSMEM 27 47 1 (Potential). FT DOMAIN 48 55 Cytoplasmic (Potential). FT TRANSMEM 56 76 2 (Potential). FT DOMAIN 77 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT DOMAIN 122 134 Cytoplasmic (Potential). FT TRANSMEM 135 155 4 (Potential). FT DOMAIN 156 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 293 7 (Potential). FT DOMAIN 294 311 Cytoplasmic (Potential). FT DISULFID 98 190 By similarity. FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 311 AA; 34789 MW; 31F86526CC4C869B CRC64; MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI RMDSHLHTPM YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII QYFIFSTMGL SESCLMTAMA YDRYAAICNP LLYSSIMSPT LCVWMVLGAY MTGLTASLFQ IGALLQLHFC GSNVIRHFFC DMPQLLILSC TDTFFVQVMT AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN TCASHLTAVS LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD ALKRLQKRKC C // ID OAG7_HUMAN STANDARD; PRT; 311 AA. AC Q8NGN6; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 10G7. GN OR10G7. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10G7". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065754; BAC05974.1; -. DR Genew; HGNC:14842; OR10G7. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 44 1 (Potential). FT DOMAIN 45 52 Cytoplasmic (Potential). FT TRANSMEM 53 73 2 (Potential). FT DOMAIN 74 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT DOMAIN 120 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT DOMAIN 160 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT DOMAIN 217 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 268 Extracellular (Potential). FT TRANSMEM 269 289 7 (Potential). FT DOMAIN 290 311 Cytoplasmic (Potential). FT DISULFID 96 188 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 311 AA; 34516 MW; D507B511CF7B1D22 CRC64; MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTNMMTGRSC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANEMVIFV NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC ASHCIVVLCF FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK LKNGSVFAQG E // ID ODF1_HUMAN STANDARD; PRT; 319 AA. AC Q8NGS4; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 13F1. GN OR13F1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR13F1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065715; BAC05936.1; -. DR Genew; HGNC:14723; OR13F1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 319 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 319 AA; 35646 MW; E94042C324763A39 CRC64; MFPANWTSVK VFFFLGFFHY PKVQVIIFAV CLLMYLITLL GNIFLISITI LDSHLHTPMY LFLSNLSFLD IWYSSSALSP MLANFVSGRN TISFSGCATQ MYLSLAMGST ECVLLPMMAY DRYVAICNPL RYPVIMNRRT CVQIAAGSWM TGCLTAMVEM MSVLPLSLCG NSIINHFTCE ILAILKLVCV DTSLVQLIML VISVLLLPMP MLLICISYAF ILASILRISS VEGRSKAFST CTAHLMVVVL FYGTALSMHL KPSAVDSQEI DKFMALVYAG QTPMLNPIIY SLRNKEVKVA LKKLLIRNHF NTAFISILK // ID O4D5_HUMAN STANDARD; PRT; 318 AA. AC Q8NGN0; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 4D5. GN OR4D5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4D5". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065760; BAC05980.1; -. DR Genew; HGNC:14852; OR4D5. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 235 Cytoplasmic (Potential). FT TRANSMEM 236 258 6 (Potential). FT DOMAIN 259 269 Extracellular (Potential). FT TRANSMEM 270 289 7 (Potential). FT DOMAIN 290 318 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 318 AA; 35770 MW; 587D3AF60FF8B135 CRC64; MNPANHSQVA GFVLLGLSQV WELRFVFFTV FSAVYFMTVV GNLLIVVIVT SDPHLHTTMY FLLGNLSFLD FCYSSITAPR MLVDLLSGNP TISFGGCLTQ LFFFHFIGGI KIFLLTVMAY DRYIAISQPL HYTLIMNQTV CALLMAASWV GGFIHSIVQI ALTIQLPFCG PDKLDNFYCD VPQLIKLACT DTFVLELLMV SNNGLVTLMC FLVLLGSYTA LLVMLRSHSR EGRSKALSTC ASHIAVVTLI FVPCIYVYTR PFRTFPMDKA VSVLYTIVTP MLNPAIYTLR NKEVIMAMKK LWRRKKDPIG PLEHRPLH // ID OAG4_HUMAN STANDARD; PRT; 311 AA. AC Q8NGN3; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 10G4. GN OR10G4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10G4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065757; BAC05977.1; -. DR Genew; HGNC:14809; OR10G4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 44 1 (Potential). FT DOMAIN 45 52 Cytoplasmic (Potential). FT TRANSMEM 53 73 2 (Potential). FT DOMAIN 74 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT DOMAIN 120 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT DOMAIN 160 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT DOMAIN 217 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 268 Extracellular (Potential). FT TRANSMEM 269 289 7 (Potential). FT DOMAIN 290 311 Cytoplasmic (Potential). FT DISULFID 96 188 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 311 AA; 34569 MW; A46CBCE6EF461752 CRC64; MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANVMVIFV DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC ASHCIVVLCF FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK LRDKVAHPQR K // ID O1D2_PANTR STANDARD; PRT; 312 AA. AC Q9TUA8; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 1D2. GN OR1D2. OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99443869; PubMed=10512677; RA Sharon D., Glusman G., Pilpel Y., Khen M., Gruetzner F., Haaf T., RA Lancet D.; RT "Primate evolution of an olfactory receptor cluster: diversification RT by gene conversion and recent emergence of pseudogenes."; RL Genomics 61:24-36(1999). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF101731; AAF03316.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 196 Extracellular (Potential). FT TRANSMEM 197 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 271 Extracellular (Potential). FT TRANSMEM 272 291 7 (Potential). FT DOMAIN 292 312 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 195 195 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 312 AA; 35212 MW; 460E872B721CEFA3 CRC64; MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSCLHTPMY FFLANLSFTD LFFVTNTIPK MLVNLQSQNK AISYAGCLTQ LYFLVSLVAL DNLILAVMAY DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE MYVLLRMACS NIQTNHTVLI ATGCFIFLIP FGFVIISYVL IIRAILRIPS LSKKYKAFST CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL GRLLDKHFKR LT // ID OAV1_HUMAN STANDARD; PRT; 309 AA. AC Q8NGI7; Q96R50; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 10V1. GN OR10V1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-284 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10V1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065807; BAC06026.1; -. DR EMBL; AF399593; AAK95078.1; -. DR Genew; HGNC:15136; OR10V1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT DOMAIN 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 161 4 (Potential). FT DOMAIN 162 198 Extracellular (Potential). FT TRANSMEM 199 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 293 7 (Potential). FT DOMAIN 294 309 Cytoplasmic (Potential). FT DISULFID 98 190 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CONFLICT 123 123 R -> Q (in Ref. 1). SQ SEQUENCE 309 AA; 34773 MW; BF411D24C880553F CRC64; MEGINKTAKM QFFFRPFSPD PEVQMLIFVV FLMMYLTSLG GNATIAVIVQ INHSLHTPMY FFLANLAVLE IFYTSSITPL ALANLLSMGK TPVSITGCGT QMFFFVFLGG ADCVLLVVMA YDRFIAICHP LRYRLIMSWS LCVELLVGSL VLGFLLSLPL TILIFHLPFC HNDEIYHFYC DMPAVMRLAC ADTRVHKTAL YIISFIVLSI PLSLISISYV FIVVAILRIR SAEGRQQAYS TCSSHILVVL LQYGCTSFIY LSPSSSYSPE MGRVVSVAYT FITPILNPLI YSLRNKELKD ALRKALRKF // ID O4N5_HUMAN STANDARD; PRT; 308 AA. AC Q8IXE1; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 4N5. GN OR4N5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4N5". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065890; BAC45262.1; -. DR Genew; HGNC:15358; OR4N5. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 235 Cytoplasmic (Potential). FT TRANSMEM 236 258 6 (Potential). FT DOMAIN 259 269 Extracellular (Potential). FT TRANSMEM 270 289 7 (Potential). FT DOMAIN 290 308 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 308 AA; 34695 MW; 4A123FBB723822BD CRC64; METQNLTVVT EFILLGLTQS QDAQLLVFVL VLIFYLIILP GNFLIIFTIK SDPGLTAPLY FFLGNLALLD ASYSFIVVPR MLVDFLSEKK VISYRSCITQ LFFLHFLGAG EMFLLVVMAF DRYIAICRPL HYSTIMNPRA CYALSLVLWL GGFIHSIVQV ALILHLPFCG PNQLDNFFCD VPQVIKLACT NTFVVELLMV SNSGLLSLLC FLGLLASYAV ILCRIREHSS EGKSKAISTC TTHIIIIFLM FGPAIFIYTC PFQAFPADKV VSLFHTVIFP LMNPVIYTLR NQEVKASMRK LLSQHMFC // ID O6J2_HUMAN STANDARD; PRT; 347 AA. AC Q8NGC5; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 6J2. GN OR6J2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR6J2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065892; BAC06108.1; -. DR Genew; HGNC:14734; OR6J2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 24 Extracellular (Potential). FT TRANSMEM 25 45 1 (Potential). FT DOMAIN 46 53 Cytoplasmic (Potential). FT TRANSMEM 54 74 2 (Potential). FT DOMAIN 75 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT DOMAIN 120 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT DOMAIN 160 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT DOMAIN 217 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT DOMAIN 292 347 Cytoplasmic (Potential). FT DISULFID 96 188 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 347 AA; 38693 MW; 69A4D98D2075920C CRC64; MGNWTAAVTE FVLLGFSLSR EVELLLLVLL LPTFLLTLLG NLLIISTVLS CSRLHTPMYF FLCNLSILDI LFTSVISPKV LANLGSRDKT ISFAGCITQC YFYFFLGTVE FLLLTVMSYD RYATICCPLR YTTIMRPSVC IGTVVFSWVG GFLSVLFPTI LISQLPFCGS NIINHFFCDS GPLLALACAD TTAIELMDFM LSSMVILCCI VLVAYSYTYI ILTIVRIPSA SGRKKAFNTC ASHLTIVIIP SGITVFIYVT PSQKEYLEIN KIPLVLSSVV TPFLNPFIYT LRNDTVQGVL RDVWVRVRGV FEKRMRAVLR SRLSSNKDHQ GRACSSPPCV YSVKLQC // ID O4M2_HUMAN STANDARD; PRT; 313 AA. AC Q8NGB6; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 4M2. GN OR4M2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4M2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065903; BAC06118.1; -. DR Genew; HGNC:15373; OR4M2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 237 Cytoplasmic (Potential). FT TRANSMEM 238 260 6 (Potential). FT DOMAIN 261 271 Extracellular (Potential). FT TRANSMEM 272 291 7 (Potential). FT DOMAIN 292 313 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 313 AA; 35382 MW; CCE0D4347BF3DF33 CRC64; METANYTKVT EFVLTGLSQT PEVQLVLFVI FLSFYLFILP GNILIICTIS LDPHLTSPMY FLLANLAFLD IWYSSITAPE MLIDFFVERK IISFDGCIAQ LFFLHFAGAS EMFLLTVMAF DLYTAICRPL HYATIMNQRL CCILVALSWR GGFIHSIIQV ALIVRLPFCG PNELDSYFCD ITQVVRIACA NTFPEELVMI CSSGLISVVC LIALLMSYAF LLALLKKLSG SGENTNRAMS TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFNTLI FPLRNPIIYT LRNKEVKAAM RKLVTKYILC KEK // ID OAJ1_HUMAN STANDARD; PRT; 320 AA. AC P30954; Q96R56; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 10J1 (Olfactory receptor-like protein HGMP07J). GN OR10J1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Testis; RX MEDLINE=92131132; PubMed=1370859; RA Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., RA Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., RA Grootegoed A., Vassart G.; RT "Expression of members of the putative olfactory receptor gene family RT in mammalian germ cells."; RL Nature 355:453-455(1992). RN [2] RP SEQUENCE OF 79-294 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10J1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X64995; CAA46128.1; -. DR EMBL; AF399587; AAK95072.1; -. DR PIR; S20573; S20573. DR Genew; HGNC:8175; OR10J1. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007338; P:fertilization (sensu Animalia); TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 57 1 (Potential). FT DOMAIN 58 65 Cytoplasmic (Potential). FT TRANSMEM 66 86 2 (Potential). FT DOMAIN 87 110 Extracellular (Potential). FT TRANSMEM 111 131 3 (Potential). FT DOMAIN 132 150 Cytoplasmic (Potential). FT TRANSMEM 151 171 4 (Potential). FT DOMAIN 172 207 Extracellular (Potential). FT TRANSMEM 208 227 5 (Potential). FT DOMAIN 228 247 Cytoplasmic (Potential). FT TRANSMEM 248 268 6 (Potential). FT DOMAIN 269 281 Extracellular (Potential). FT TRANSMEM 282 302 7 (Potential). FT DOMAIN 303 320 Cytoplasmic (Potential). FT DISULFID 108 199 By similarity. FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 320 AA; 35925 MW; C2CF3513FF1EBC5F CRC64; MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL AGNIIIVTII RIDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS QPMSLAGCAT QMFFFVTFGI TNCFLLTAMG YDRYVAICNP LRYMVIMNKR LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC ARKVPHFFCD IRPVMKLSCI DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS VEGRKKAFAT CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY TLRNKEVKDA LCRAVGGKFS // ID OLF6_RAT STANDARD; PRT; 311 AA. AC P23267; DT 01-NOV-1991 (Rel. 20, Created) DT 01-NOV-1991 (Rel. 20, Last sequence update) DT 01-JUL-1993 (Rel. 26, Last annotation update) DE Olfactory receptor-like protein F6. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91191556; PubMed=1840504; RA Buck L., Axel R.; RT "A novel multigene family may encode odorant receptors: a molecular RT basis for odor recognition."; RL Cell 65:175-187(1991). CC -!- FUNCTION: PUTATIVE ODORANT RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: OLFACTORY EPITHELIUM. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M64378; AAA41741.1; -. DR PIR; C23701; C23701. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 28 53 1 (POTENTIAL). FT DOMAIN 54 60 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 61 82 2 (POTENTIAL). FT DOMAIN 83 103 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 104 123 3 (POTENTIAL). FT DOMAIN 124 142 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 143 161 4 (POTENTIAL). FT DOMAIN 162 199 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 200 222 5 (POTENTIAL). FT DOMAIN 223 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 263 6 (POTENTIAL). FT DOMAIN 264 275 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 276 295 7 (POTENTIAL). FT DOMAIN 296 311 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 100 192 BY SIMILARITY. SQ SEQUENCE 311 AA; 34168 MW; 9E092CFE85A58BF1 CRC64; MAWSTGQNLS TPGPFILLGF PGPRSMRIGL FLLFLVMYLL TVVGNLAIIS LVGAHRCLQT PMYFFLCNLS FLEIWFTTAC VPKTLATFAP RGGVISLAGC ATQMYFVFSL GCTEYFLLAV MAYDRYLAIC LPLRYGGIMT PGLAMRLALG SWLCGFSAIT VPATLIARLS FCGSRVINHF FCDISPWIVL SCTDTQVVEL VSFGIAFCVI LGSCGITLVS YAYIITTIIK IPSARGRHRA FSTCSSHLTV VLIWYGSTIF LHVRTSVESS LDLTKAITVL NTIVTPVLNP FIYTLRNKDV KEALRRTVKG K // ID O6P1_HUMAN STANDARD; PRT; 317 AA. AC Q8NGX9; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 6P1. GN OR6P1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR6P1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065637; BAC05863.1; -. DR Genew; HGNC:15036; OR6P1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 317 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 186 186 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 35830 MW; D888EFD6653E95B1 CRC64; MRNLSGGHVE EFVLVGFPTT PPLQLLLFVL FFAIYLLTLL ENALIVFTIW LAPSLHRPMY FFLGHLSFLE LWYINVTIPR LLAAFLTQDG RVSYVGCMTQ LYFFIALACT ECVLLAVMAY DRYLAICGPL LYPSLMPSSL ATRLAAASWG SGFFSSMMKL LFISQLSYCG PNIINHFFCD ISPLLNLTCS DKEQAELVDF LLALVMILLP LLAVVSSYTA IIAAILRIPT SRGRHKAFST CAAHLAVVVI YYSSTLFTYA RPRAMYTFNH NKIISVLYTI IVPFFNPAIY CLRNKEVKEA FRKTVMGRCH YPRDVQD // ID O2T5_HUMAN STANDARD; PRT; 315 AA. AC Q8NH02; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 2T5. GN OR2T5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2T5". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065613; BAC05840.1; ALT_INIT. DR Genew; HGNC:15017; OR2T5. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 29 Extracellular (Potential). FT TRANSMEM 30 53 1 (Potential). FT DOMAIN 54 61 Cytoplasmic (Potential). FT TRANSMEM 62 83 2 (Potential). FT DOMAIN 84 104 Extracellular (Potential). FT TRANSMEM 105 124 3 (Potential). FT DOMAIN 125 143 Cytoplasmic (Potential). FT TRANSMEM 144 162 4 (Potential). FT DOMAIN 163 199 Extracellular (Potential). FT TRANSMEM 200 223 5 (Potential). FT DOMAIN 224 240 Cytoplasmic (Potential). FT TRANSMEM 241 263 6 (Potential). FT DOMAIN 264 276 Extracellular (Potential). FT TRANSMEM 277 296 7 (Potential). FT DOMAIN 297 315 Cytoplasmic (Potential). FT DISULFID 101 193 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 315 AA; 35594 MW; E8AFED7EC21079CD CRC64; MANITRMANH TGRLDFILMG LFRQSKHPAL LSVVIFVVFL KALSGNAVLI LLIHCDAHLH SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE CGMQMFLYLT LAGSEFFLLA TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS GCWFLGSVDG FMLTPITMSF PFCRSWEIHH FFCEVPAVTI LSCSDTSLYE TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK AFATCSSHLT VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD VMGALKKMLT VRFVL // ID O4F4_HUMAN STANDARD; PRT; 305 AA. AC Q96R69; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 4F4 (HS14a-1-A). GN OR4F4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE OF 61-274 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4F4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF399574; AAK95059.1; -. DR Genew; HGNC:8301; OR4F4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Multigene family; KW Olfaction. FT DOMAIN 1 18 Extracellular (Potential). FT TRANSMEM 19 42 1 (Potential). FT DOMAIN 43 50 Cytoplasmic (Potential). FT TRANSMEM 51 72 2 (Potential). FT DOMAIN 73 93 Extracellular (Potential). FT TRANSMEM 94 113 3 (Potential). FT DOMAIN 114 132 Cytoplasmic (Potential). FT TRANSMEM 133 151 4 (Potential). FT DOMAIN 152 188 Extracellular (Potential). FT TRANSMEM 189 212 5 (Potential). FT DOMAIN 213 228 Cytoplasmic (Potential). FT TRANSMEM 229 251 6 (Potential). FT DOMAIN 252 262 Extracellular (Potential). FT TRANSMEM 263 282 7 (Potential). FT DOMAIN 283 305 Cytoplasmic (Potential). FT DISULFID 90 182 By similarity. SQ SEQUENCE 305 AA; 34259 MW; 903D4D8E98EA07F6 CRC64; MVTEFIFLGL SDSQELQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS PMYFLLANLS LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF GGSEMVILIA MGFDRYIAIC KPLHYTTIMC GNACVGIMAV AWGIGFLHSV SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL ACTDTYRLDI MVIANSGVLT VCSFVLLIIS YTIILMTIQH CPLDKSSKAL STLTAHITVV LLFFGPCVFI YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRRLRKWDAH SSVKF // ID O4FH_HUMAN STANDARD; PRT; 305 AA. AC Q8NGA8; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 4F17. GN OR4F17 OR OR4F19. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4F17". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065917; BAC06132.1; -. DR Genew; HGNC:15381; OR4F17. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Multigene family; KW Olfaction. FT DOMAIN 1 18 Extracellular (Potential). FT TRANSMEM 19 42 1 (Potential). FT DOMAIN 43 50 Cytoplasmic (Potential). FT TRANSMEM 51 72 2 (Potential). FT DOMAIN 73 93 Extracellular (Potential). FT TRANSMEM 94 113 3 (Potential). FT DOMAIN 114 132 Cytoplasmic (Potential). FT TRANSMEM 133 151 4 (Potential). FT DOMAIN 152 188 Extracellular (Potential). FT TRANSMEM 189 212 5 (Potential). FT DOMAIN 213 228 Cytoplasmic (Potential). FT TRANSMEM 229 251 6 (Potential). FT DOMAIN 252 262 Extracellular (Potential). FT TRANSMEM 263 282 7 (Potential). FT DOMAIN 283 305 Cytoplasmic (Potential). FT DISULFID 90 182 By similarity. SQ SEQUENCE 305 AA; 34212 MW; 2DDFAC5504EDFA6E CRC64; MVTEFIFLGL SDSQGLQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS PMYFLLANLS LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF GGSEMVILIA MGFDRYIAIC KPLHYTTIMC GNACVGIMAV AWGIGFLHSV SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL ACTDTYRLDI MVIANSGVLT VCSFVLLIIS YTIILMTIQH RPLDKSSKAL STLTAHITVV LLFFGPCVFI YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRQLRKWDAH SSVKF // ID O4F5_HUMAN STANDARD; PRT; 305 AA. AC Q8NH21; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 4F5. GN OR4F5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4F5". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065592; BAC05820.1; -. DR Genew; HGNC:14825; OR4F5. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Multigene family; KW Olfaction. FT DOMAIN 1 18 Extracellular (Potential). FT TRANSMEM 19 42 1 (Potential). FT DOMAIN 43 50 Cytoplasmic (Potential). FT TRANSMEM 51 72 2 (Potential). FT DOMAIN 73 93 Extracellular (Potential). FT TRANSMEM 94 113 3 (Potential). FT DOMAIN 114 132 Cytoplasmic (Potential). FT TRANSMEM 133 151 4 (Potential). FT DOMAIN 152 188 Extracellular (Potential). FT TRANSMEM 189 212 5 (Potential). FT DOMAIN 213 228 Cytoplasmic (Potential). FT TRANSMEM 229 251 6 (Potential). FT DOMAIN 252 262 Extracellular (Potential). FT TRANSMEM 263 282 7 (Potential). FT DOMAIN 283 305 Cytoplasmic (Potential). FT DISULFID 90 182 By similarity. SQ SEQUENCE 305 AA; 34330 MW; 70E99D068AB2DD59 CRC64; MVTEFIFLGL SDSQELQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS PMYFLLANLS LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF GGSEMVILIA MGFDRYIAIC KPLHYTTIMC GNACVGIMAV TWGIGFLHSV SQLAFAVHLL FCGPNEVDSF YCDLPRVIKL ACTDTYRLDI MVIANSGVLT VCSFVLLIIS YTIILMTIQH RPLDKSSKAL STLTAHITVV LLFFGPCVFI YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRQLRKWDAH SSVKF // ID O6K6_HUMAN STANDARD; PRT; 319 AA. AC Q8NGW6; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 6K6. GN OR6K6. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR6K6". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065650; BAC05876.1; -. DR Genew; HGNC:15033; OR6K6. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 29 Extracellular (Potential). FT TRANSMEM 30 50 1 (Potential). FT DOMAIN 51 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT DOMAIN 80 103 Extracellular (Potential). FT TRANSMEM 104 124 3 (Potential). FT DOMAIN 125 143 Cytoplasmic (Potential). FT TRANSMEM 144 164 4 (Potential). FT DOMAIN 165 200 Extracellular (Potential). FT TRANSMEM 201 220 5 (Potential). FT DOMAIN 221 240 Cytoplasmic (Potential). FT TRANSMEM 241 261 6 (Potential). FT DOMAIN 262 274 Extracellular (Potential). FT TRANSMEM 275 295 7 (Potential). FT DOMAIN 296 319 Cytoplasmic (Potential). FT DISULFID 101 193 By similarity. FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 319 AA; 35531 MW; 83A9C35DAAA3B4B9 CRC64; MTQLTASGNQ TMVTEFLFSM FPHAHRGGLL FFIPLLLIYG FILTGNLIMF IVIQVGMALH TPLYFFISVL SFLEICYTTT TIPKMLSCLI SEQKSISVAG CLLQMYFFHS LGITESCVLT AMAIDRYIAI CNPLRYPTIM IPKLCIQLTV GSCFCGFLLV LPEIAWISTL PFCGSNQIHQ IFCDFTPVLS LACTDTFLVV IVDAIHAAEI VASFLVIALS YIRIIIVILG MHSAEGHHKA FSTCAAHLAV FLLFFGSVAV MYLRFSATYS VFWDTAIAVT FVILAPFFNP IIYSLKNKDM KEAIGRLFHY QKRAGWAGK // ID OBH1_HUMAN STANDARD; PRT; 315 AA. AC Q8NG94; Q96R32; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 11H1 (Olfactory receptor 22-1) (OR22-1). GN OR11H1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 72-288 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR11H1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065933; BAC06148.1; ALT_INIT. DR EMBL; AF399611; AAK95096.1; -. DR Genew; HGNC:15404; OR11H1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 29 Extracellular (Potential). FT TRANSMEM 30 50 1 (Potential). FT DOMAIN 51 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT DOMAIN 80 103 Extracellular (Potential). FT TRANSMEM 104 124 3 (Potential). FT DOMAIN 125 143 Cytoplasmic (Potential). FT TRANSMEM 144 164 4 (Potential). FT DOMAIN 165 201 Extracellular (Potential). FT TRANSMEM 202 221 5 (Potential). FT DOMAIN 222 241 Cytoplasmic (Potential). FT TRANSMEM 242 262 6 (Potential). FT DOMAIN 263 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT DOMAIN 297 315 Cytoplasmic (Potential). FT DISULFID 101 193 By similarity. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 95 95 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 315 AA; 35420 MW; 78E1EEED8D82F80D CRC64; MNVSEPNSSF AFVNEFILQG FSCEWTIQIF LFSLFTTTYA LTITGNGAIA FVLWCDRRLH TPMYMFLGNF SFLEIWYVSS TVPKMLVNFL SEKKNISFAG CFLQFYFFFS LGTSECLLLT VMAFDQYLAI CRPLLYPNIM TGHLYAKLVI LCWVCGFLWF LIPIVLISQM PFCGPNIIDH VVCDPGPRFA LDCVSAPRIQ LFCYTLSSLV IFGNFLFIIG SYTLVLKAML GMPSSTGRHK AFSTCGSHLA VVSLCYSSLM VMYVSPGLGH STGMQKIETL FYAMVTPLFN PLIYSLQNKE IKAALRKVLG SSNII // ID O5AT_HUMAN STANDARD; PRT; 309 AA. AC Q8NHC5; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 5AT1. GN OR5AT1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5AT1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065441; BAC05708.1; -. DR Genew; HGNC:15022; OR5AT1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 44 1 (Potential). FT DOMAIN 45 52 Cytoplasmic (Potential). FT TRANSMEM 53 73 2 (Potential). FT DOMAIN 74 97 Extracellular (Potential). FT TRANSMEM 98 118 3 (Potential). FT DOMAIN 119 131 Cytoplasmic (Potential). FT TRANSMEM 132 152 4 (Potential). FT DOMAIN 153 194 Extracellular (Potential). FT TRANSMEM 195 215 5 (Potential). FT DOMAIN 216 235 Cytoplasmic (Potential). FT TRANSMEM 236 255 6 (Potential). FT DOMAIN 256 268 Extracellular (Potential). FT TRANSMEM 269 289 7 (Potential). FT DOMAIN 290 309 Cytoplasmic (Potential). FT DISULFID 95 187 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 87 87 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 309 AA; 34307 MW; C5A4E2C8E8A06A76 CRC64; MANLTIVTEF ILMGFSTNKN MCILHSILFL LIYLCALMGN VLIIMITTLD HHLHTPVYFF LKNLSFLDLC LISVTAPKSI ANSLIHNNSI SFLGCVSQVF LLLSSASAEL LLLTVMSFDR YTAICHPLHY DVIMDRSTCV QRATVSWLYG GLIAVMHTAG TFSLSYCGSN MVHQFFCDIP QLLAISCSEN LIREIALILI NVVLDFCCFI VIIITYVHVF STVKKIPSTE GQSKAYSICL PHLLVVLFLS TGFIAYLKPA SESPSILDAV ISVFYTMLPP TFNPIIYSLR NKAIKVALGM LIKGKLTKK // ID OYE4_HUMAN STANDARD; PRT; 312 AA. AC Q8NGH9; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52E4. GN OR52E4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52E4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065817; BAC06036.1; -. DR Genew; HGNC:15213; OR52E4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 274 Extracellular (Potential). FT TRANSMEM 275 295 7 (Potential). FT DOMAIN 296 312 Cytoplasmic (Potential). FT DISULFID 99 191 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 312 AA; 35480 MW; EBB273B03A05149A CRC64; MPSINDTHFY PPFFLLLGIP GLDTLHIWIS FPFCIVYLIA IVGNMTILFV IKTEHSLHQP MFYFLAMLSM IDLGLSTSTI PKMLGIFWFN LQEISFGGCL LQMFFIHMFT GMETVLLVVM AYDRFVAICN PLQYTMILTN KTISILASVV VGRNLVLVTP FVFLILRLPF CGHNIVPHTY CEHRGLAGLA CAPIKINIIY GLMVISYIIV DVILIASSYV LILRAVFRLP SQDVRLKAFN TCGSHVCVML CFYTPAFFSF MTHRFGQNIP HYIHILLANL YVVVPPALNP VIYGVRTKQI REQIVKIFVQ KE // ID OYB6_HUMAN STANDARD; PRT; 314 AA. AC Q8NGF0; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52B6. GN OR52B6. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52B6". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065858; BAC06076.1; ALT_INIT. DR Genew; HGNC:15211; OR52B6. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 24 Extracellular (Potential). FT TRANSMEM 25 45 1 (Potential). FT DOMAIN 46 53 Cytoplasmic (Potential). FT TRANSMEM 54 74 2 (Potential). FT DOMAIN 75 98 Extracellular (Potential). FT TRANSMEM 99 118 3 (Potential). FT DOMAIN 119 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 4 (Potential). FT DOMAIN 159 194 Extracellular (Potential). FT TRANSMEM 195 215 5 (Potential). FT DOMAIN 216 235 Cytoplasmic (Potential). FT TRANSMEM 236 256 6 (Potential). FT DOMAIN 257 272 Extracellular (Potential). FT TRANSMEM 273 293 7 (Potential). FT DOMAIN 294 314 Cytoplasmic (Potential). FT DISULFID 96 187 By similarity. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 314 AA; 34808 MW; 21F2BF2F5FA6C13C CRC64; MNNSDTRIAG CFLTGIPGLE QLHIWLSIPF CIMYIAALEG NGILICVILS QAILHEPMYI FLSMLASADV LLSTTTMPKA LANLWLGYSH ISFDGCLTQM FFIHFLFIHS AVLLAMAFDR YVAICSPLRY VTILTSKVIG KIVTATLSRS FIIMFPSIFL LEHLHYCQIN IIAHTFCEHM GIAHLSCSDI SINVWYGLAA ALLSTGLDIM LITVSYIHIL QAVFRLLSQD ARSKALSTCG SHICVILLFY VPALFSVFAY RFGGRSIPCY VHILLASLYV VIPPMLNPVI YGVRTKPILE GAKQMFSNLA KGSK // ID OYI2_HUMAN STANDARD; PRT; 324 AA. AC Q8NH67; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52I2. GN OR52I2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52I2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065522; BAC05770.1; ALT_INIT. DR Genew; HGNC:15221; OR52I2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 29 Extracellular (Potential). FT TRANSMEM 30 50 1 (Potential). FT DOMAIN 51 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT DOMAIN 80 103 Extracellular (Potential). FT TRANSMEM 104 124 3 (Potential). FT DOMAIN 125 143 Cytoplasmic (Potential). FT TRANSMEM 144 164 4 (Potential). FT DOMAIN 165 200 Extracellular (Potential). FT TRANSMEM 201 221 5 (Potential). FT DOMAIN 222 241 Cytoplasmic (Potential). FT TRANSMEM 242 262 6 (Potential). FT DOMAIN 263 278 Extracellular (Potential). FT TRANSMEM 279 299 7 (Potential). FT DOMAIN 300 324 Cytoplasmic (Potential). FT DISULFID 101 193 By similarity. FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 324 AA; 35280 MW; F6DA55BED04E3650 CRC64; MLGPAYNHTM ETPASFLLVG IPGLQSSHLW LAISLSAMYI IALLGNTIIV TAIWMDSTRH EPMYCFLCVL AAVDIVMASS VVPKMVSIFC SGDSSISFSA CFTQMFFVHL ATAVETGLLL TMAFDRYVAI CKPLHYKRIL TPQVMLGMSM AITIRAIIAI TPLSWMVSHL PFCGSNVVVH SYCEHIALAR LACADPVPSS LYSLIGSSLM VGSDVAFIAA SYILILKAVF GLSSKTAQLK ALSTCGSHVG VMALYYLPGM ASIYAAWLGQ DVVPLHTQVL LADLYVIIPA TLNPIIYGMR TKQLRERIWS YLMHVLFDHS NLGS // ID OZA4_HUMAN STANDARD; PRT; 313 AA. AC Q8NGH8; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 56A4. GN OR56A4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR56A4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065818; BAC06037.1; -. DR Genew; HGNC:14791; OR56A4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 Extracellular (Potential). FT TRANSMEM 29 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 78 2 (Potential). FT DOMAIN 79 102 Extracellular (Potential). FT TRANSMEM 103 123 3 (Potential). FT DOMAIN 124 142 Cytoplasmic (Potential). FT TRANSMEM 143 163 4 (Potential). FT DOMAIN 164 199 Extracellular (Potential). FT TRANSMEM 200 220 5 (Potential). FT DOMAIN 221 240 Cytoplasmic (Potential). FT TRANSMEM 241 261 6 (Potential). FT DOMAIN 262 276 Extracellular (Potential). FT TRANSMEM 277 297 7 (Potential). FT DOMAIN 298 313 Cytoplasmic (Potential). FT DISULFID 100 192 By similarity. FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 184 184 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 313 AA; 35143 MW; FF1CFF4380F45896 CRC64; MASPNNDSTA PVSEFLLICF PNFQSWQHWL SLPLSLLFLL AMGANTTLLI TIQLEASLHQ PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC FLQMFIMNSF LTMESCTFMV MAYDRYVAIC HPLRYPSIIT DQFVARAVVF VIARNAFVSL PVPMLSARLR YCAGNIIKNC ICSNLSVSKL SCDDITFNQL YQFVAGWTLL GSDLILIVIS YSFILKVVLR IKAEGAVAKA LSTCGSHFIL ILFFSTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK EIKQGIQNLL KRL // ID PE23_BOVIN STANDARD; PRT; 417 AA. AC P34979; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Prostaglandin E2 receptor, EP3 subtype (Prostanoid EP3 receptor) (PGE DE receptor, EP3 subtype). GN PTGER3. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. (ISOFORMS EP3A; EP3B; EP3C AND EP3D). RC TISSUE=Adrenal medulla; RX MEDLINE=93382504; PubMed=8396726; RA Namba T., Sugimoto Y., Negish M., Irie A., Ushikubi F., RA Kakizuka A., Ito S., Ichikawa A., Narumiya S.S.; RT "Alternative splicing of C-terminal tail of prostaglandin E receptor RT subtype EP3 determines G-protein specificity."; RL Nature 365:166-170(1993). CC -!- FUNCTION: Receptor for prostaglandin E2 (PGE2); the EP3 receptor CC may be involved in inhibition of gastric acid secretion, CC modulation of neurotransmitter release in central and peripheral CC neurons, inhibition of sodium and water reabsorption in kidney CC tubulus and contraction in uterine smooth muscle. The activity of CC this receptor can couple to both the inhibition of adenylate CC cyclase mediated by G-I proteins, and to an elevation of CC intracellular calcium. The various isoforms have identical ligand CC binding properties but interact with different second messenger CC systems: isoform EP3A couples to G(I)/G(0) proteins; isoform EP3B CC and isoform EP3C couple to G(S), and isoform EP3D couples TO G(I), CC G(S) and G(P). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Comment=Additional isoforms seem to exist; CC Name=EP3A; CC IsoId=P34979-1; Sequence=Displayed; CC Name=EP3B; CC IsoId=P34979-2; Sequence=VSP_001929, VSP_001930; CC Name=EP3C; CC IsoId=P34979-3; Sequence=VSP_001931, VSP_001932; CC Name=EP3D; CC IsoId=P34979-4; Sequence=VSP_001933, VSP_001934; CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D21345; BAA04811.1; -. DR EMBL; D21346; BAA04812.1; -. DR EMBL; D21347; BAA04813.1; -. DR EMBL; D21348; BAA04814.1; -. DR PIR; S36764; S36764. DR PIR; S36765; S36765. DR PIR; S36766; S36766. DR PIR; S36767; S36767. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008365; ProstanoidR. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01788; PROSTANOIDR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate; Phosphorylation; Alternative splicing. FT DOMAIN 1 52 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 53 77 1 (POTENTIAL). FT DOMAIN 78 90 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 91 111 2 (POTENTIAL). FT DOMAIN 112 130 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 131 152 3 (POTENTIAL). FT DOMAIN 153 174 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 175 196 4 (POTENTIAL). FT DOMAIN 197 226 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 227 252 5 (POTENTIAL). FT DOMAIN 253 282 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 283 306 6 (POTENTIAL). FT DOMAIN 307 326 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 327 348 7 (POTENTIAL). FT DOMAIN 349 417 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 17 17 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 35 35 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 216 216 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 307 307 N-LINKED (GLCNAC...) (POTENTIAL). FT VARSPLIC 359 387 LLKGHSYGLDTEGGTENKDKEMKENLYIS -> VANAVSSY FT FNDGPKVPTISLSNEITQTGA (in isoform EP3B). FT /FTId=VSP_001929. FT VARSPLIC 388 417 Missing (in isoform EP3B). FT /FTId=VSP_001930. FT VARSPLIC 359 362 LLKG -> HVGS (in isoform EP3C). FT /FTId=VSP_001931. FT VARSPLIC 363 417 Missing (in isoform EP3C). FT /FTId=VSP_001932. FT VARSPLIC 359 385 LLKGHSYGLDTEGGTENKDKEMKENLY -> ASPRSMWDPS FT SPTRDRTRVPCIGSTES (in isoform EP3D). FT /FTId=VSP_001933. FT VARSPLIC 386 417 Missing (in isoform EP3D). FT /FTId=VSP_001934. SQ SEQUENCE 417 AA; 46362 MW; B0EF29238CC0C6EB CRC64; MKATRDHASA PFCTRFNHSD PGIWAAERAV EAPNNLTLPP EPSEDCGSVS VAFSMTMMIT GFVGNALAIT LVSKSYRRRE GKRKKSFLLC IGWLALTDMV GQLLTSPVVI VLYLSHQRWE QLDPSGRLCT FFGLTMTVFG LSSLFIASAM AVERALATRA PHWYSSHMKT SVTRAVLLGV WLAVLAFALL PVLGVGQYTI QWPGTWCFIS TGPGGNGTNS RQNWGNVFFA SAFAILGLSA LVVTFACNLA TIKALVSRCR AKATASQSSA QWGRITTETA IQLMGIMCVL SVCWSPLLIM MLKMIFNHTS VEHCKTYTEN QDECNFFLIA VRLASLNQIL DPWVYLLLRK ILLQKFCQLL KGHSYGLDTE GGTENKDKEM KENLYISNLS RFFILLGHFT EARRGRGHIY LHTLEHQ // ID PI2R_RAT STANDARD; PRT; 416 AA. AC P43253; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) DE (Prostaglandin I2 receptor). GN PTGIR. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=95101758; PubMed=7803522; RA Sasaki Y., Usui T., Tanaka I., Nakagawa O., Sando T., Takahashi T., RA Namba T., Narumiya S., Nakao K.; RT "Cloning and expression of a cDNA for rat prostacyclin receptor."; RL Biochim. Biophys. Acta 1224:601-605(1994). CC -!- FUNCTION: Receptor for prostacyclin (prostaglandin I2 or PGI2). CC The activity of this receptor is mediated by G(s) proteins which CC activate adenylate cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D28966; BAA06091.1; -. DR PIR; S52078; S52078. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008365; ProstanoidR. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01788; PROSTANOIDR. DR PRINTS; PR00429; THROMBOXANER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate. FT DOMAIN 1 45 Extracellular (Potential). FT TRANSMEM 46 67 1 (Potential). FT DOMAIN 68 80 Cytoplasmic (Potential). FT TRANSMEM 81 105 2 (Potential). FT DOMAIN 106 123 Extracellular (Potential). FT TRANSMEM 124 144 3 (Potential). FT DOMAIN 145 163 Cytoplasmic (Potential). FT TRANSMEM 164 187 4 (Potential). FT DOMAIN 188 215 Extracellular (Potential). FT TRANSMEM 216 237 5 (Potential). FT DOMAIN 238 264 Cytoplasmic (Potential). FT TRANSMEM 265 289 6 (Potential). FT DOMAIN 290 302 Extracellular (Potential). FT TRANSMEM 303 323 7 (Potential). FT DOMAIN 324 416 Cytoplasmic (Potential). FT LIPID 336 336 S-palmitoyl cysteine (By similarity). FT LIPID 339 339 S-palmitoyl cysteine (By similarity). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 416 AA; 44662 MW; 03171B5ED21C4171 CRC64; MVASGGRPDG PPSITPESPL IVGGREWQGM AGSCWNITYV QDSVGPATST LMFVAGVVGN GLALGILGAR RRSHPSAFAV LVTGLAVTDL LGTCFLSPAV FVAYARNSSL LGLAHGGTML CDTFAFAMTF FGLASTLILF AMAVERCLAL SHPYLYAQLD GPRCARLALP AIYAFCCLFC SLPLLGLGEH QQYCPGSWCF IRMRSPQPGG CAFSLAYASL MALLVTSIFF CNGSVTLSLC HMYRQQRRHH GSFVPTSRAR EDEVYHLILL ALMTGIMAVC SLPLTIRGFT QAIAPDSREM GDLHAFRFNA FNPILDPWVF ILFRKAVFQR LKFWLCCLCA RSVHGDLQTP LSRPVSGRRD TLAPDSLQAK EGNWVPLSTW GTGQVAPLTA VPLSGGDGCS VGMPSKTEAV VACSLC // ID AA1R_MOUSE STANDARD; PRT; 326 AA. AC Q60612; Q9WUF9; DT 01-NOV-1997 (Rel. 35, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Adenosine A1 receptor. GN ADORA1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BALB/c; TISSUE=Brain; RX MEDLINE=94209670; PubMed=8157966; RA Marquardt D.L., Walker L.L., Heinemann S.; RT "Cloning of two adenosine receptor subtypes from mouse bone marrow- RT derived mast cells."; RL J. Immunol. 152:4508-4515(1994). RN [2] RP SEQUENCE OF 1-107 FROM N.A. RX MEDLINE=99253981; PubMed=10318839; RA Rivkees S.A., Chen M., Kulkarni J., Browne J., Zhao Z.; RT "Characterization of the murine A1 adenosine receptor promoter, potent RT regulation by GATA-4 and Nkx2.5."; RL J. Biol. Chem. 274:14204-14209(1999). CC -!- FUNCTION: RECEPTOR FOR ADENOSINE. THE ACTIVITY OF THIS RECEPTOR CC IS MEDIATED BY G PROTEINS WHICH INHIBIT ADENYLYL CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U05671; AAA18999.1; ALT_INIT. DR EMBL; AF133099; AAD31843.1; -. DR HSSP; P29274; 1MMH. DR MGD; MGI:99401; Adora1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 10 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 11 33 1 (POTENTIAL). FT DOMAIN 34 46 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 47 69 2 (POTENTIAL). FT DOMAIN 70 80 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 81 102 3 (POTENTIAL). FT DOMAIN 103 123 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 124 146 4 (POTENTIAL). FT DOMAIN 147 176 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 177 201 5 (POTENTIAL). FT DOMAIN 202 235 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 236 259 6 (POTENTIAL). FT DOMAIN 260 267 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 268 292 7 (POTENTIAL). FT DOMAIN 293 326 CYTOPLASMIC (POTENTIAL). FT DISULFID 80 169 BY SIMILARITY. FT CARBOHYD 148 148 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 159 159 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 309 309 S-palmitoyl cysteine (Potential). FT CONFLICT 10 10 A -> G (IN REF. 1). FT CONFLICT 107 107 L -> P (IN REF. 2). SQ SEQUENCE 326 AA; 36652 MW; 6E5B72D94447963C CRC64; MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS EVEQAWIANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL KIWNDHFRCQ PKPPIEEDIP EEKAED // ID AA1R_BOVIN STANDARD; PRT; 326 AA. AC P28190; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Adenosine A1 receptor. GN ADORA1. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=92201360; PubMed=1551415; RA Tucker A.L., Linden J., Robeva A.S., D'Angelo D.D., Lynch K.R.; RT "Cloning and expression of a bovine adenosine A1 receptor cDNA."; RL FEBS Lett. 297:107-111(1992). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=92268130; PubMed=1587851; RA Olah M.E., Ren H., Ostrowski J., Jacobson K., Stiles G.L.; RT "Cloning, expression, and characterization of the unique bovine A1 RT adenosine receptor. Studies on the ligand binding site by RT site-directed mutagenesis."; RL J. Biol. Chem. 267:10764-10770(1992). CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is CC mediated by G proteins which inhibit adenylyl cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X63592; CAA45135.1; -. DR EMBL; M86261; AAA30350.1; -. DR PIR; A38144; A38144. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00552; ADENOSINEA1R. DR PRINTS; PR00424; ADENOSINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 10 Extracellular (Potential). FT TRANSMEM 11 33 1 (Potential). FT DOMAIN 34 46 Cytoplasmic (Potential). FT TRANSMEM 47 69 2 (Potential). FT DOMAIN 70 80 Extracellular (Potential). FT TRANSMEM 81 102 3 (Potential). FT DOMAIN 103 123 Cytoplasmic (Potential). FT TRANSMEM 124 146 4 (Potential). FT DOMAIN 147 176 Extracellular (Potential). FT TRANSMEM 177 201 5 (Potential). FT DOMAIN 202 235 Cytoplasmic (Potential). FT TRANSMEM 236 259 6 (Potential). FT DOMAIN 260 267 Extracellular (Potential). FT TRANSMEM 268 292 7 (Potential). FT DOMAIN 293 326 Cytoplasmic (Potential). FT DISULFID 80 169 By similarity. FT CARBOHYD 148 148 N-linked (GlcNAc...) (Potential). FT CARBOHYD 159 159 N-linked (GlcNAc...) (Potential). FT LIPID 309 309 S-palmitoyl cysteine (Potential). FT CONFLICT 101 101 M -> I (in Ref. 2). SQ SEQUENCE 326 AA; 36597 MW; 1697A5F303A57285 CRC64; MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA LVIPLAILIN IGPRTYFHTC LKVACPVLIL TQSSILALLA MAVDRYLRVK IPLRYKTVVT PRRAVVAITG CWILSFVVGL TPMFGWNNLS AVERDWLANG SVGEPVIECQ FEKVISMEYM VYFNFFVWVL PPLLLMVLIY MEVFYLIRKQ LSKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL HILNCITLFC PSCHMPRILI YIAIFLSHGN SAMNPIVYAF RIQKFRVTFL KIWNDHFRCQ PAPPIDEDAP AERPDD // ID AA2A_RAT STANDARD; PRT; 410 AA. AC P30543; DT 01-APR-1993 (Rel. 25, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Adenosine A2a receptor. GN ADORA2A. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=92287111; PubMed=1599465; RA Chern Y., King K., Lai H.-L., Lai H.-T.; RT "Molecular cloning of a novel adenosine receptor gene from rat RT brain."; RL Biochem. Biophys. Res. Commun. 185:304-309(1992). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Striatum; RX MEDLINE=93061787; PubMed=1279342; RA Fink J.S., Weaver D.R., Rivkees S.A., Peterfreund R.A., Pollack A.E., RA Adler E.M., Reppert S.M.; RT "Molecular cloning of the rat A2 adenosine receptor: selective co- RT expression with D2 dopamine receptors in rat striatum."; RL Brain Res. Mol. Brain Res. 14:186-195(1992). RN [3] RP SEQUENCE FROM N.A. RA Yip L., Hewitt J., Kwok Y.; RT "Rattus norvegicus mucosa A2A adenosine receptor mRNA."; RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: RECEPTOR FOR ADENOSINE. THE ACTIVITY OF THIS RECEPTOR CC IS MEDIATED BY G PROTEINS WHICH ACTIVATE ADENYLYL CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M91214; AAA70305.1; -. DR EMBL; L08102; -; NOT_ANNOTATED_CDS. DR EMBL; S47609; AAA11888.1; -. DR EMBL; AF228684; AAF61924.1; -. DR PIR; JT0607; JT0607. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 4 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 5 27 1 (POTENTIAL). FT DOMAIN 28 40 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 41 63 2 (POTENTIAL). FT DOMAIN 64 74 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 75 97 3 (POTENTIAL). FT DOMAIN 98 117 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 118 140 4 (POTENTIAL). FT DOMAIN 141 168 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 169 193 5 (POTENTIAL). FT DOMAIN 194 229 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 230 253 6 (POTENTIAL). FT DOMAIN 254 261 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 262 285 7 (POTENTIAL). FT DOMAIN 286 410 CYTOPLASMIC (POTENTIAL). FT DISULFID 74 161 BY SIMILARITY. FT CARBOHYD 142 142 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 149 149 N-LINKED (GLCNAC...) (POTENTIAL). FT CONFLICT 183 183 L -> T (IN REF. 1). FT CONFLICT 268 268 A -> T (IN REF. 1). SQ SEQUENCE 410 AA; 44998 MW; D87B256CD2336BAC CRC64; MGSSVYITVE LAIAVLAILG NVLVCWAVWI NSNLQNVTNF FVVSLAAADI AVGVLAIPFA ITISTGFCAA CHGCLFFACF VLVLTQSSIF SLLAIAIDRY IAIRIPLRYN GLVTGVRAKG IIAICWVLSF AIGLTPMLGW NNCSQKDGNS TKTCGEGRVT CLFEDVVPMN YMVYYNFFAF VLLPLLLMLA IYLRIFLAAR RQLKQMESQP LPGERTRSTL QKEVHAAKSL AIIVGLFALC WLPLHIINCF TFFCSTCRHA PPWLMYLAII LSHSNSVVNP FIYAYRIREF RQTFRKIIRT HVLRRQEPFQ AGGSSAWALA AHSTEGEQVS LRLNGHPLGV WANGSATHSG RRPNGYTLGL GGGGSAQGSP RDVELPTQER QEGQEHPGLR GHLVQARVGA SSWSSEFAPS // ID AA2A_HUMAN STANDARD; PRT; 412 AA. AC P29274; DT 01-DEC-1992 (Rel. 24, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Adenosine A2a receptor. GN ADORA2A OR ADORA2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Tiffany H.L., Murphy P.M.; RL Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Salvatore C.A., Luneau C.J., Johnson R.G., Jacobson M.; RL Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Hippocampus; RX MEDLINE=93061821; PubMed=1331670; RA Furlong T.J., Pierce K.D., Selbie L.A., Shine J.; RT "Molecular characterization of a human brain adenosine A2 receptor."; RL Brain Res. Mol. Brain Res. 15:62-66(1992). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=96264663; PubMed=8670304; RA Le F., Townsend-Nicholson A., Baker E., Sutherland G.R., RA Schofield P.R.; RT "Characterization and chromosomal localization of the human A2a RT adenosine receptor gene: ADORA2A."; RL Biochem. Biophys. Res. Commun. 223:461-467(1996). RN [5] RP SEQUENCE FROM N.A. RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE FROM N.A. RC TISSUE=Lymph; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP 3D-STRUCTURE MODELING OF TRANSMEMBRANE DOMAINS. RX MEDLINE=95294002; PubMed=7775460; RA Kim J., Wess J., van Rhee A.M., Schoneberg T., Jacobson K.A.; RT "Site-directed mutagenesis identifies residues involved in ligand RT recognition in the human A2a adenosine receptor."; RL J. Biol. Chem. 270:13987-13997(1995). RN [8] RP VARIANT VAL-50. RX MEDLINE=99318093; PubMed=10391209; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [9] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is CC mediated by G proteins which activate adenylyl cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M97370; AAA58356.1; ALT_INIT. DR EMBL; X68486; CAA48504.1; -. DR EMBL; S46950; AAB23956.1; -. DR EMBL; U40771; AAA83270.1; -. DR EMBL; U40770; AAA83270.1; JOINED. DR EMBL; AY136747; AAN01273.1; -. DR EMBL; BC013780; AAH13780.1; -. DR PIR; A48978; A48978. DR PDB; 1MMH; 29-JAN-96. DR Genew; HGNC:263; ADORA2A. DR MIM; 102776; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005624; C:membrane fraction; TAS. DR GO; GO:0006915; P:apoptosis; TAS. DR GO; GO:0007596; P:blood coagulation; TAS. DR GO; GO:0006171; P:cAMP biosynthesis; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0006968; P:cellular defense response; TAS. DR GO; GO:0007417; P:central nervous system development; TAS. DR GO; GO:0008015; P:circulation; TAS. DR GO; GO:0007188; P:G-protein signaling, coupled to cAMP nucleo...; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR GO; GO:0006909; P:phagocytosis; TAS. DR GO; GO:0007600; P:sensory perception; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00553; ADENOSINA2AR. DR PRINTS; PR00424; ADENOSINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; 3D-structure; KW Polymorphism. FT DOMAIN 1 7 Extracellular (Potential). FT TRANSMEM 8 30 1 (Potential). FT DOMAIN 31 43 Cytoplasmic (Potential). FT TRANSMEM 44 66 2 (Potential). FT DOMAIN 67 77 Extracellular (Potential). FT TRANSMEM 78 100 3 (Potential). FT DOMAIN 101 120 Cytoplasmic (Potential). FT TRANSMEM 121 143 4 (Potential). FT DOMAIN 144 173 Extracellular (Potential). FT TRANSMEM 174 198 5 (Potential). FT DOMAIN 199 234 Cytoplasmic (Potential). FT TRANSMEM 235 258 6 (Potential). FT DOMAIN 259 266 Extracellular (Potential). FT TRANSMEM 267 290 7 (Potential). FT DOMAIN 291 412 Cytoplasmic (Potential). FT DISULFID 77 166 By similarity. FT CARBOHYD 154 154 N-linked (GlcNAc...) (Potential). FT VARIANT 50 50 A -> V (in dbSNP:4530). FT /FTId=VAR_011835. FT VARIANT 300 300 R -> H (in dbSNP:4990). FT /FTId=VAR_011836. FT VARIANT 392 392 G -> R. FT /FTId=VAR_003451. FT HELIX 7 35 FT HELIX 43 68 FT HELIX 79 101 FT HELIX 118 142 FT HELIX 176 202 FT HELIX 234 258 FT HELIX 265 295 SQ SEQUENCE 412 AA; 44707 MW; 9438E9D64A6BE61B CRC64; MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR AKGIIAICWV LSFAIGLTPM LGWNNCGQPK EGKNHSQGCG EGQVACLFED VVPMNYMVYF NFFACVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS APHPERRPNG YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL DDPLAQDGAG VS // ID P2Y8_XENLA STANDARD; PRT; 537 AA. AC P79928; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE P2Y purinoceptor 8 (P2Y8). GN P2RY8. OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus. OX NCBI_TaxID=8355; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Neural plate; RX MEDLINE=97284734; PubMed=9139711; RA Bogdanov Y.D., Dale L., King B.F., Whittock N., Burnstock G.; RT "Early expression of a novel nucleotide receptor in the neural plate RT of Xenopus embryos."; RL J. Biol. Chem. 272:12583-12590(1997). CC -!- FUNCTION: RECEPTOR FOR EXTRACELLULAR ATP, UTP, CTP, GTP AND ITP. CC THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH CC ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. CC MAY PLAY A KEY ROLE IN THE EARLY DEVELOPMENT OF NEURAL TISSUE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X99953; CAA68213.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 49 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 50 70 1 (POTENTIAL). FT DOMAIN 71 79 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 80 100 2 (POTENTIAL). FT DOMAIN 101 118 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 119 139 3 (POTENTIAL). FT DOMAIN 140 161 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 162 182 4 (POTENTIAL). FT DOMAIN 183 210 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 211 231 5 (POTENTIAL). FT DOMAIN 232 254 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 255 275 6 (POTENTIAL). FT DOMAIN 276 292 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 293 316 7 (POTENTIAL). FT DOMAIN 317 537 CYTOPLASMIC (POTENTIAL). FT DISULFID 116 193 BY SIMILARITY. FT CARBOHYD 26 26 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 29 29 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 537 AA; 62024 MW; B2CF24812F3C19F2 CRC64; MTEDIMATSY PTFLTTPYLP MKLLMNLTND TEDICVFDEG FKFLLLPVSY SAVFMVGLPL NIAAMWIFIA KMRPWNPTTV YMFNLALSDT LYVLSLPTLV YYYADKNNWP FGEVLCKLVR FLFYANLYSS ILFLTCISVH RYRGVCHPIT SLRRMNAKHA YVICALVWLS VTLCLVPNLI FVTVSPKVKN TICHDTTRPE DFARYVEYST AIMCLLFGIP CLIIAGCYGL MTRELMKPIV SGNQQTLPSY KKRSIKTIIF VMIAFAICFM PFHITRTLYY YARLLGIKCY ALNVINVTYK VTRPLASANS CIDPILYFLA NDRYRRRLIR TVRRRSSVPN RRCMHTNHPQ TEPHMTAGPL PVISAEEIPS NGSMVRDENG EGSREHRVEW TDTKEINQMM NRRSTIKRNS TDKNDMKENR HGENYLPYVE VVEKEDYETK RENRKTTEQS SKTNAEQDEL QTQIDSRLKR GKWQLSSKKG AAQENEKGHM EPSFEGEGTS TWNLLTPKMY GKKDRLAKNV EEVGYGKEKE LQNFPKA // ID P2Y2_MOUSE STANDARD; PRT; 373 AA. AC P35383; O09031; Q9CPZ4; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) DE (Purinergic receptor). GN P2RY2 OR P2RU1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93281707; PubMed=7685114; RA Lustig K.D., Shiau A.K., Brake A.J., Julius D.; RT "Expression cloning of an ATP receptor from mouse neuroblastoma RT cells."; RL Proc. Natl. Acad. Sci. U.S.A. 90:5113-5117(1993). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=96316177; PubMed=8739319; RA Enomoto K., Furuya K., Moore R.C., Yamagishi S., Oka T., Maeno T.; RT "Expression cloning and signal transduction pathway of P2U receptor RT in mammary tumor cells."; RL Biol. Signals 5:9-21(1996). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6J; TISSUE=Head, and Liver; RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Breast tumor; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP MUTAGENESIS OF LYS-107; ARG-110; HIS-262; ARG-265; LYS-289 AND RP ARG-292. RX MEDLINE=95181393; PubMed=7876172; RA Erb L., Garrad R.C., Wang Y., Quinn T., Turner J.T., Weisman G.A.; RT "Site-directed mutagenesis of P2U purinoceptors. Positively charged RT amino acids in transmembrane helices 6 and 7 affect agonist potency RT and specificity."; RL J. Biol. Chem. 270:4185-4188(1995). CC -!- FUNCTION: Receptor for ATP and UTP coupled to G-proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP CC = ADP. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Spleen, testis, kidney, liver, lung, heart and CC brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L14751; AAA39871.1; -. DR EMBL; S83099; AAB50735.1; -. DR EMBL; AK005013; BAB23746.1; -. DR EMBL; AK017378; BAB30719.1; -. DR EMBL; BC006613; AAH06613.1; -. DR PIR; A47556; A47556. DR HSSP; P34996; 1DDD. DR MGD; MGI:105107; P2ry2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 32 Extracellular (Potential). FT TRANSMEM 33 59 1 (Potential). FT DOMAIN 60 70 Cytoplasmic (Potential). FT TRANSMEM 71 93 2 (Potential). FT DOMAIN 94 110 Extracellular (Potential). FT TRANSMEM 111 129 3 (Potential). FT DOMAIN 130 152 Cytoplasmic (Potential). FT TRANSMEM 153 172 4 (Potential). FT DOMAIN 173 194 Extracellular (Potential). FT TRANSMEM 195 220 5 (Potential). FT DOMAIN 221 246 Cytoplasmic (Potential). FT TRANSMEM 247 269 6 (Potential). FT DOMAIN 270 287 Extracellular (Potential). FT TRANSMEM 288 309 7 (Potential). FT DOMAIN 310 373 Cytoplasmic (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT DISULFID 106 183 By similarity. FT MUTAGEN 107 107 K->I: No effect on receptor activation. FT MUTAGEN 110 110 R->L: No effect on receptor activation. FT MUTAGEN 262 262 H->L: Decrease in receptor activation. FT MUTAGEN 265 265 R->L: Decrease in receptor activation. FT MUTAGEN 289 289 K->I: No effect on receptor activation. FT MUTAGEN 292 292 R->L: Decrease in receptor activation. FT CONFLICT 17 17 E -> D (in Ref. 2). FT CONFLICT 120 120 S -> R (in Ref. 2). FT CONFLICT 125 125 T -> N (in Ref. 2). FT CONFLICT 196 196 V -> M (in Ref. 2). FT CONFLICT 263 263 V -> L (in Ref. 3). FT CONFLICT 355 355 D -> N (in Ref. 2). FT CONFLICT 369 371 KDI -> PYV (in Ref. 2). SQ SEQUENCE 373 AA; 42174 MW; 590BBE502E41B3AE CRC64; MAADLEPWNS TINGTWEGDE LGYKCRFNED FKYVLLPVSY GVVCVLGLCL NVVALYIFLC RLKTWNASTT YMFHLAVSDS LYAASLPLLV YYYARGDHWP FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLH SLRWGRARYA RRVAAVVWVL VLACQAPVLY FVTTSVRGTR ITCHDTSARE LFSHFVAYSS VMLGLLFAVP FSVILVCYVL MARRLLKPAY GTTGGLPRAK RKSVRTIALV LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKI TRPLASANSC LDPVLYFLAG QRLVRFARDA KPPTEPTPSP QARRKLGLHR PNRTVRKDLS VSSDDSRRTE STPAGSETKD IRL // ID CB1R_RAT STANDARD; PRT; 473 AA. AC P20272; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1991 (Rel. 17, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE Cannabinoid receptor 1 (CB1) (CB-R) (Brain-type cannabinoid receptor). GN CNR1 OR SKR6. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain cortex; RX MEDLINE=90332039; PubMed=2165569; RA Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I.; RT "Structure of a cannabinoid receptor and functional expression of the RT cloned cDNA."; RL Nature 346:561-564(1990). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=96429553; PubMed=8832654; RA Ho B.Y., Zhao J.; RT "Determination of the cannabinoid receptors in mouse x rat hybridoma RT NG108-15 cells and rat GH4C1 cells."; RL Neurosci. Lett. 212:123-126(1996). CC -!- FUNCTION: Involved in cannabinoid-induced CNS effects. Acts by CC inhibiting adenylate cyclase. Could be a receptor for anandamide. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X55812; CAA39332.1; -. DR EMBL; U40395; AAA99067.1; -. DR PIR; A33117; A33117. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 117 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 118 143 1 (POTENTIAL). FT DOMAIN 144 155 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 156 176 2 (POTENTIAL). FT DOMAIN 177 188 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 189 213 3 (POTENTIAL). FT DOMAIN 214 233 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 234 256 4 (POTENTIAL). FT DOMAIN 257 274 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 275 300 5 (POTENTIAL). FT DOMAIN 301 345 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 346 366 6 (POTENTIAL). FT DOMAIN 367 378 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 379 400 7 (POTENTIAL). FT DOMAIN 401 473 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 78 78 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 84 84 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 473 AA; 52845 MW; E59A66AFE17B646C CRC64; MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE KMTAGDNSPL VPAGDTTNIT EFYNKSLSSF KENEENIQCG ENFMDMECFM ILNPSQQLAI AVLSLTLGTF TVLENLLVLC VILHSRSLRC RPSYHFIGSL AVADLLGSVI FVYSFVDFHV FHRKDSPNVF LFKLGGVTAS FTASVGSLFL TAIDRYISIH RPLAYKRIVT RPKAVVAFCL MWTIAIVIAV LPLLGWNCKK LQSVCSDIFP LIDETYLMFW IGVTSVLLLF IVYAYMYILW KAHSHAVRMI QRGTQKSIII HTSEDGKVQV TRPDQARMDI RLAKTLVLIL VVLIICWGPL LAIMVYDVFG KMNKLIKTVF AFCSMLCLLN STVNPIIYAL RSKDLRHAFR SMFPSCEGTA QPLDNSMGDS DCLHKHANNT ASMHRAAESC IKSTVKIAKV TMSVSTDTSA EAL // ID CB1B_FUGRU STANDARD; PRT; 470 AA. AC Q98895; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE Cannabinoid receptor type 1B. GN CB1B. OS Fugu rubripes (Japanese pufferfish) (Takifugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; OC Tetradontoidea; Tetraodontidae; Takifugu. OX NCBI_TaxID=31033; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Testis; RX MEDLINE=97001167; PubMed=8812500; RA Yamaguchi F., Macrae A., Brenner S.; RT "Molecular cloning of two cannabinoid type 1-like receptor genes from RT the puffer fish Fugu rubripes."; RL Genomics 35:603-605(1996). CC -!- FUNCTION: INVOLVED IN CANNABINOID-INDUCED CNS EFFECTS (POTENTIAL). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X94402; CAA64175.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 113 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 114 139 1 (POTENTIAL). FT DOMAIN 140 151 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 152 172 2 (POTENTIAL). FT DOMAIN 173 184 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 185 209 3 (POTENTIAL). FT DOMAIN 210 229 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 230 252 4 (POTENTIAL). FT DOMAIN 253 270 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 271 296 5 (POTENTIAL). FT DOMAIN 297 341 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 342 362 6 (POTENTIAL). FT DOMAIN 363 374 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 375 396 7 (POTENTIAL). FT DOMAIN 397 470 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 78 78 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 86 86 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 470 AA; 52081 MW; CEE87CD37FDF9192 CRC64; MKLALHRIAG ATMAALTTEV QYLGSNDASY EDPQADAALM KSRFNFEKPY SASSSLHRLI PGNKELIYGG LSTILPTNAS DFPLSNGSGE ATQCGEDIVD NMECFMILTP AQQLVIVILA ITLGTFTVLE NFVVLCVILH SHTLRSRPSY HFIGSLAVAD LIGSIIFVYS FLDFHVLHRK DSPSIFLFKL AGVIASFTAS VGSLFLTAID RYVSIHRPMA YKRIITKTKA VIAFSVMWAI SIEFSLLPLL GWNCKRLHSV CSDIFPLIDE KYLMFWIGMT TVLLLFIIYA YMFILWKSHH HAVRMLSRSS QRSIIVYTSE GTKVQTVRPE QARMDLRLAK TLVLILVALI ICWGPLLAIM VYDLFGRVND FIKTVFAFCS MLCLLNSTIN PVIYAMRSKD LRRAFVNICH MCRGTTQSLD SSAESDWNSR SVRSTGGRAG KDRSVGGKPQ VKVAQVTVSG VTASSPAEAV // ID PAFR_HUMAN STANDARD; PRT; 342 AA. AC P25105; DT 01-MAY-1992 (Rel. 22, Created) DT 01-MAY-1992 (Rel. 22, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Platelet activating factor receptor (PAF-R). GN PTAFR OR PAFR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=92028922; PubMed=1656963; RA Ye R.D., Prossnitz E.R., Zou A., Cochrane C.G.; RT "Characterization of a human cDNA that encodes a functional receptor RT for platelet activating factor."; RL Biochem. Biophys. Res. Commun. 180:105-111(1991). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Leukocyte; RX MEDLINE=92041873; PubMed=1657923; RA Nakamura M., Honda Z., Izumi T., Sakanaka C., Mutoh H., Minami M., RA Bito H., Seyama Y., Matsumoto T., Noma M., Shimizu T.; RT "Molecular cloning and expression of platelet-activating factor RT receptor from human leukocytes."; RL J. Biol. Chem. 266:20400-20405(1991). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=92250505; PubMed=1374385; RA Kunz D., Gerard N.P., Gerard C.; RT "The human leukocyte platelet-activating factor receptor. cDNA RT cloning, cell surface expression, and construction of a novel RT epitope-bearing analog."; RL J. Biol. Chem. 267:9101-9106(1992). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=92347886; PubMed=1322356; RA Seyfried C.E., Schweickart V.L., Godiska R., Gray P.W.; RT "The human platelet-activating factor receptor gene (PTAFR) contains RT no introns and maps to chromosome 1."; RL Genomics 13:832-834(1992). RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Heart; RX MEDLINE=93112021; PubMed=1281995; RA Sugimoto T., Tsuchimochi H., McGregor C.G., Mutoh H., Shimizu T., RA Kurachi Y.; RT "Molecular cloning and characterization of the platelet-activating RT factor receptor gene expressed in the human heart."; RL Biochem. Biophys. Res. Commun. 189:617-624(1992). RN [6] RP SEQUENCE FROM N.A. RA Behal R.H., Debuysere M.S., Olson M.S.; RT "Nucleotide sequence of platelet-activating-factor receptor derived RT from HeLa cell genomic DNA and Rhesus monkey genomic DNA."; RL Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases. RN [7] RP SEQUENCE FROM N.A. RX MEDLINE=93192035; PubMed=8383507; RA Chase P.B., Halonen M., Regan J.W.; RT "Cloning of a human platelet-activating factor receptor gene: RT evidence for an intron in the 5'-untranslated region."; RL Am. J. Respir. Cell Mol. Biol. 8:240-244(1993). RN [8] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RA Warren C.N., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [9] RP SEQUENCE FROM N.A. RC TISSUE=Lymph; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [10] RP VARIANTS ASP-224 AND SER-338. RX MEDLINE=99318093; PubMed=10391209; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [11] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: Receptor for platelet activating factor, a chemotactic CC phospholipid mediator that possesses potent inflammatory, smooth- CC muscle contractile and hypotensive activity. Seem to mediate its CC action via a G protein that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M80436; AAA60001.1; -. DR EMBL; M76674; AAA60002.1; -. DR EMBL; D10202; BAA01050.1; -. DR EMBL; M88177; AAA60214.1; -. DR EMBL; S52624; AAB24695.2; -. DR EMBL; L07334; AAA60108.1; -. DR EMBL; S56396; AAB25755.1; -. DR EMBL; AY275466; AAP32298.1; -. DR EMBL; BC013816; -; NOT_ANNOTATED_CDS. DR PIR; A40191; A40191. DR Genew; HGNC:9582; PTAFR. DR MIM; 173393; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0004992; F:platelet activating factor receptor activity; TAS. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0006955; P:immune response; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Chemotaxis; KW Polymorphism. FT DOMAIN 1 16 Extracellular (Potential). FT TRANSMEM 17 38 1 (Potential). FT DOMAIN 39 54 Cytoplasmic (Potential). FT TRANSMEM 55 74 2 (Potential). FT DOMAIN 75 91 Extracellular (Potential). FT TRANSMEM 92 113 3 (Potential). FT DOMAIN 114 133 Cytoplasmic (Potential). FT TRANSMEM 134 155 4 (Potential). FT DOMAIN 156 184 Extracellular (Potential). FT TRANSMEM 185 205 5 (Potential). FT DOMAIN 206 233 Cytoplasmic (Potential). FT TRANSMEM 234 254 6 (Potential). FT DOMAIN 255 276 Extracellular (Potential). FT TRANSMEM 277 296 7 (Potential). FT DOMAIN 297 342 Cytoplasmic (Potential). FT DISULFID 90 173 By similarity. FT CARBOHYD 169 169 N-linked (GlcNAc...) (Potential). FT VARIANT 224 224 A -> D (in dbSNP:5938). FT /FTId=VAR_011851. FT VARIANT 338 338 N -> S (in dbSNP:5939). FT /FTId=VAR_011852. FT CONFLICT 28 28 L -> P (in Ref. 6). FT CONFLICT 66 66 F -> L (in Ref. 6). FT CONFLICT 95 95 C -> R (in Ref. 6). FT CONFLICT 227 228 KR -> TG (in Ref. 4). FT CONFLICT 227 228 KR -> TT (in Ref. 6). FT CONFLICT 247 247 P -> A (in Ref. 6). FT CONFLICT 316 316 K -> N (in Ref. 5). SQ SEQUENCE 342 AA; 39203 MW; 890073C9EBA79228 CRC64; MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN EIKIFMVNLT MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN TYCSVAFLGV ITYNRFQAVT RPIKTAQANT RKRGISLSLV IWVAIVGAAS YFLILDSTNT VPDSAGSGNV TRCFEHYEKG SVPVLIIHIF IVFSFFLVFL IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV FIICFVPHHV VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN // ID GRHR_HUMAN STANDARD; PRT; 328 AA. AC P30968; O75793; Q92644; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). GN GNRHR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM 1). RC TISSUE=Pituitary; RX MEDLINE=93080571; PubMed=1333190; RA Kakar S.S., Musgrove L.C., Devor D.C., Sellers J.C., Neill J.D.; RT "Cloning, sequencing, and expression of human gonadotropin releasing RT hormone (GnRH) receptor."; RL Biochem. Biophys. Res. Commun. 189:289-295(1992). RN [2] RP SEQUENCE FROM N.A. (ISOFORM 1). RC TISSUE=Pituitary; RX MEDLINE=93231377; PubMed=8386108; RA Chi L., Zhou W., Prikhozhan A., Flanagan C.A., Davidson J.S., RA Golembo M., Illing N., Millar R.P., Sealfon S.C.; RT "Cloning and characterization of the human GnRH receptor."; RL Mol. Cell. Endocrinol. 91:R1-R6(1993). RN [3] RP SEQUENCE FROM N.A. (ISOFORM 1). RX MEDLINE=95203482; PubMed=7534732; RA Kakar S.S., Grizzle W.E., Neill J.D.; RT "The nucleotide sequences of human GnRH receptors in breast and RT ovarian tumors are identical with that found in pituitary."; RL Mol. Cell. Endocrinol. 106:145-149(1994). RN [4] RP SEQUENCE FROM N.A. (ISOFORM 1). RX MEDLINE=97418071; PubMed=9272108; RA Kakar S.S.; RT "Molecular structure of the human gonadotropin-releasing hormone RT receptor gene."; RL Eur. J. Endocrinol. 137:183-192(1997). RN [5] RP SEQUENCE FROM N.A. (ISOFORM 2). RC TISSUE=Pituitary; RX MEDLINE=97402257; PubMed=9259321; RA Grosse R., Schoneberg T., Schultz G., Gudermann T.; RT "Inhibition of gonadotropin-releasing hormone receptor signaling by RT expression of a splice variant of the human receptor."; RL Mol. Endocrinol. 11:1305-1318(1997). RN [6] RP SEQUENCE OF 247-328 FROM N.A. (ISOFORM 1). RX MEDLINE=99307031; PubMed=10366411; RA Kottler M.L., Bergametti F., Carre M.C., Morice S., Decoret E., RA Lagarde J.P., Starzec A., Counis R.; RT "Tissue-specific pattern of variant transcripts of the human RT gonadotropin-releasing hormone receptor gene."; RL Eur. J. Endocrinol. 140:561-569(1999). CC -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that CC mediate the action of GnRH to stimulate the secretion of the CC gonadotropic hormones (LH and FSH). This receptor mediates its CC action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. Isoform 2 CC may act a an inhibitor of GnRH-R signaling. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P30968-1; Sequence=Displayed; CC Name=2; Synonyms=Truncated; CC IsoId=P30968-2; Sequence=VSP_001914; CC -!- TISSUE SPECIFICITY: Pituitary, ovary, testis, breast and prostate CC but not in liver and spleen. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L03380; AAA35918.1; -. DR EMBL; L07949; AAA35917.1; -. DR EMBL; S60587; AAB26287.1; -. DR EMBL; S77472; AAB33884.1; -. DR EMBL; AF001952; AAB71348.1; -. DR EMBL; AF001950; AAB71348.1; JOINED. DR EMBL; AF001951; AAB71348.1; JOINED. DR EMBL; Z81148; CAB03541.1; -. DR EMBL; Z99995; CAB17082.1; -. DR PIR; JC1353; JC1353. DR Genew; HGNC:4421; GNRHR. DR MIM; 138850; -. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004968; F:gonadotropin-releasing hormone receptor act...; TAS. DR GO; GO:0007275; P:development; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00529; GNADOTRPHINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Alternative splicing. FT DOMAIN 1 38 Extracellular (Potential). FT TRANSMEM 39 58 1 (Potential). FT DOMAIN 59 77 Cytoplasmic (Potential). FT TRANSMEM 78 97 2 (Potential). FT DOMAIN 98 115 Extracellular (Potential). FT TRANSMEM 116 137 3 (Potential). FT DOMAIN 138 164 Cytoplasmic (Potential). FT TRANSMEM 165 184 4 (Potential). FT DOMAIN 185 212 Extracellular (Potential). FT TRANSMEM 213 232 5 (Potential). FT DOMAIN 233 281 Cytoplasmic (Potential). FT TRANSMEM 282 300 6 (Potential). FT DOMAIN 301 306 Extracellular (Potential). FT TRANSMEM 307 326 7 (Potential). FT DOMAIN 327 328 Cytoplasmic (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 102 102 N-linked (GlcNAc...) (Potential). FT DISULFID 114 196 By similarity. FT VARSPLIC 176 328 YIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTF FT SCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNN FT IPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLN FT RLSDPVNHFFFLFAFLNPCFDPLIYGYFSL -> PLHHPSF FT HHADLQCKNHLHPDTGPSSGPPRTTTESVQEQYTKSTAEDS FT KNDGCICHFIYCLLDSLLCPRNLVLV (in isoform FT 2). FT /FTId=VSP_001914. FT CONFLICT 247 247 H -> T (in Ref. 6). SQ SEQUENCE 328 AA; 37730 MW; D02B2EA2F4246D7B CRC64; MANSASPEQN QNHCSAINNS IPLMQGNLPT LTLSGKIRVT VTFFLFLLSA TFNASFLLKL QKWTQKKEKG KKLSRMKLLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITRPLALK SNSKVGQSMV GLAWILSSVF AGPQLYIFRM IHLADSSGQT KVFSQCVTHC SFSQWWHQAF YNFFTFSCLF IIPLFIMLIC NAKIIFTLTR VLHQDPHELQ LNQSKNNIPR ARLKTLKMTV AFATSFTVCW TPYYVLGIWY WFDPEMLNRL SDPVNHFFFL FAFLNPCFDP LIYGYFSL // ID GRHR_CANFA STANDARD; PRT; 327 AA. AC Q9MZI6; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). GN GNRHR. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20267228; PubMed=10809231; RA Cui J., Smith R.G., Mount G.R., Lo J.L., Yu J., Walsh T.F., RA Singh S.B., DeVita R.J., Goulet M.T., Schaeffer J.M., Cheng K.; RT "Identification of Phe313 of the gonadotropin-releasing hormone (GnRH) RT receptor as a site critical for the binding of nonpeptide GnRH RT antagonists."; RL Mol. Endocrinol. 14:671-681(2000). CC -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that CC mediate the action of GnRH to stimulate the secretion of the CC gonadotropic hormones (LH and FSH). This receptor mediates its CC action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF206513; AAF87097.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 37 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 38 57 1 (POTENTIAL). FT DOMAIN 58 76 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 77 96 2 (POTENTIAL). FT DOMAIN 97 114 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 115 136 3 (POTENTIAL). FT DOMAIN 137 163 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 164 183 4 (POTENTIAL). FT DOMAIN 184 211 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 212 231 5 (POTENTIAL). FT DOMAIN 232 280 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 281 299 6 (POTENTIAL). FT DOMAIN 300 305 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 306 325 7 (POTENTIAL). FT DOMAIN 326 327 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 17 17 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 101 101 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 113 195 BY SIMILARITY. SQ SEQUENCE 327 AA; 37655 MW; 778A82A9D25D3371 CRC64; MASASPEQNQ NHCSAVNNSN MLMQGNLPTL TLSGKIRVTV TFFLFLLSTI FNASFLLKLQ KWTQKKEKGK KLSRMKVLLK HLTLANLLET LIVMPLDGMW NITVQWYAGE FLCKVLSYLK LFSMYAPAFM MVVISLDRSL AITRPLAMKN NGKLGQSMIG LAWLLSGIFA GPQLYIFRMI HLADSSGQTE GFPQCVTHCS FPQWWHQAFY NFFTFSCLFI IPLFITLICN AKIIFTLTRV LHQDPHELQL NQSKNNIPRA RLRTLKMTVA FATSFTVCWT PYYVLGIWYW FDPEMLNRVS DPVNHFFFLF ALLNPCFDPL IYGYFSL // ID GRHR_CAVPO STANDARD; PRT; 328 AA. AC Q8CH60; DT 10-OCT-2003 (Rel. 42, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). GN GNRHR. OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Hartley; RA Fujii Y., Ikemoto T., Park M.K.; RT "Molecular cloning of a GnRH receptor in the guinea pig."; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that CC mediate the action of GnRH to stimulate the secretion of the CC gonadotropic hormones (LH and FSH). This receptor mediates its CC action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF426176; AAN75711.2; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001658; GphnRH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00529; GNADOTRPHINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 38 Extracellular (Potential). FT TRANSMEM 39 59 1 (Potential). FT DOMAIN 60 84 Cytoplasmic (Potential). FT TRANSMEM 85 105 2 (Potential). FT DOMAIN 106 115 Extracellular (Potential). FT TRANSMEM 116 136 3 (Potential). FT DOMAIN 137 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT DOMAIN 182 208 Extracellular (Potential). FT TRANSMEM 209 229 5 (Potential). FT DOMAIN 230 271 Cytoplasmic (Potential). FT TRANSMEM 272 292 6 (Potential). FT DOMAIN 293 306 Extracellular (Potential). FT TRANSMEM 307 327 7 (Potential). FT DOMAIN 328 328 Cytoplasmic (Potential). FT DISULFID 114 196 By similarity. FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 328 AA; 37689 MW; 7DCE4E9609D2B161 CRC64; MQDDTSSEQN PTHCSAINSS VPLVQGALPT LTLSGKIRVT VTFFLFLVST TLNASFLLKL QKWTQKKEKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKILSYL KLFSMYAPAF MMVVISLDRS MAITRPLPVQ SNRKLEQSMT GLAWGLSSVL AGPQLYIFKM IHLENGPGQT EVFSQCVTHC SFPQWWHQAF YNFFTFICLF IIPLLIMLIC NAKIIFTLTQ VLQQDSNKLQ LNQSKNNIPR ARLRTLKMTV AFAASFIVCW TPYYVLGLWY WFDPGMLHRM SEPVNHFFFL FAFLNPCFDP LIYGYFSL // ID GRHR_TRIVU STANDARD; PRT; 328 AA. AC Q9TTI8; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). GN GNRHR. OS Trichosurus vulpecula (Brush-tailed possum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Diprotodontia; Phalangeridae; Trichosurus. OX NCBI_TaxID=9337; RN [1] RP SEQUENCE FROM N.A. RA Lawrence S.B., McNatty K.P., Fidler A.E.; RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that CC mediate the action of GnRH to stimulate the secretion of the CC gonadotropic hormones (LH and FSH). This receptor mediates its CC action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF032379; AAF21641.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 58 1 (POTENTIAL). FT DOMAIN 59 77 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 78 97 2 (POTENTIAL). FT DOMAIN 98 115 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 116 137 3 (POTENTIAL). FT DOMAIN 138 164 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 165 184 4 (POTENTIAL). FT DOMAIN 185 212 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 213 232 5 (POTENTIAL). FT DOMAIN 233 281 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 282 300 6 (POTENTIAL). FT DOMAIN 301 306 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 307 326 7 (POTENTIAL). FT DOMAIN 327 328 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 102 102 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 192 192 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 114 196 BY SIMILARITY. SQ SEQUENCE 328 AA; 37986 MW; DEE5EA2DEA582DE8 CRC64; MANRAYLEQK QTQCSIINSS FSMTHRDLPT LTLSGKIRVM VTFFLFLVST AFNASFLMKL QRQTQKKEEV KKLTRMKVLL KHLTLANLLE TVIVMPLDGI WNVTVQWYAG EFLCKALSYL KLFSMYAPAF MMVVISLDRF LAITRPLAVK SNTKVGQSLI AVAWFLSIVL AGPQLYIFRM IYVEDISGQT GNFSQCVTHC SFPEWWQEAF YNLLTFSCLF IGPLLIMLVC NAKIIFTLTQ VLHQDPHELQ LNRSKNNIPR ARLRTLKMTV AFATLFTICW TPYYVLGIWY WFDPEMLNRV SDPVNHFFFL FGLLNPCFDP LIYGYFSL // ID GRR2_CLAGA STANDARD; PRT; 379 AA. AC O42329; DT 15-JUL-1998 (Rel. 36, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Gonadotropin-releasing hormone II receptor (Type II GnRH receptor) DE (GnRH-II-R). OS Clarias gariepinus (Sharptooth catfish) (African catfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; OC Clariidae; Clarias. OX NCBI_TaxID=13013; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Pituitary; RX MEDLINE=97182593; PubMed=9030732; RA Tensen C.P., Okuzawa K., Blomenroehr M., Rebers F.E.M., Leurs R., RA Bogerd J., Schulz R.W., Goos H.J.T.; RT "Distinct efficacies for two endogenous ligands on a single cognate RT gonadoliberin receptor."; RL Eur. J. Biochem. 243:134-140(1997). RN [2] RP REVISION TO 56. RA Bogerd J.; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for gonadotropin releasing hormone II (GnRH CC II). This receptor mediates its action by association with G CC proteins that activate a phosphatidylinositol-calcium second CC messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on the C-terminal cytoplasmic tail (Probable). CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X97497; CAA66128.2; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation. FT DOMAIN 1 45 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 46 65 1 (POTENTIAL). FT DOMAIN 66 80 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 81 100 2 (POTENTIAL). FT DOMAIN 101 118 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 119 140 3 (POTENTIAL). FT DOMAIN 141 167 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 168 184 4 (POTENTIAL). FT DOMAIN 185 210 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 211 230 5 (POTENTIAL). FT DOMAIN 231 283 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 284 302 6 (POTENTIAL). FT DOMAIN 303 308 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 309 328 7 (POTENTIAL). FT DOMAIN 329 379 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 23 23 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 105 105 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 117 194 BY SIMILARITY. SQ SEQUENCE 379 AA; 42771 MW; 194430926562678D CRC64; MSGNTTLLLS NPTNVLDNSS VLNVSVSPPV LKWETPTFTT AARFRVAATL VLFVFAAASN LSVLLSVTRG RGRRLASHLR PLIASLASAD LVMTFVVMPL DAVWNVTVQW YAGDAMCKLM CFLKLFAMHS AAFILVVVSL DRHHAILHPL DTLDAGRRNR RMLLTAWILS LLLASPQLFI FRAIKAKGVD FVQCATHGSF QQHWQETAYN MFHFVTLYVF PLLVMSLCYT RILVEINRQM HRSKDKAGEP CLRRSGTDMI PKARMKTLKM TIIIVASFVI CWTPYYLLGI WYWFQPQMLH VIPDYVHHVF FVFGNLNTCC DPVIYGFFTP SFRADLSRCF CWRNQNASAK SLPHFSGHRR EVSGEAESDL GSGDQPSGQ // ID TRFR_HUMAN STANDARD; PRT; 398 AA. AC P34981; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin DE receptor). GN TRHR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93371401; PubMed=8395824; RA Matre V., Karlsen H.E., Wright M.S., Lundell I., Fjeldheim K., RA Gabrielsen O.S., Larhammar D., Gautvik K.M.; RT "Molecular cloning of a functional human thyrotropin-releasing RT hormone receptor."; RL Biochem. Biophys. Res. Commun. 195:179-185(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Pituitary; RX MEDLINE=93384596; PubMed=8396925; RA Yamada M., Monden T., Satoh T., Satoh N., Murakami M., Iriuchijima T., RA Kakegawa T., Mori M.; RT "Pituitary adenomas of patients with acromegaly express thyrotropin- RT releasing hormone receptor messenger RNA: cloning and functional RT expression of the human thyrotropin-releasing hormone receptor RT gene."; RL Biochem. Biophys. Res. Commun. 195:737-745(1993). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=94063224; PubMed=8243797; RA Duthie S.M., Taylor P.L., Anderson L., Cook J., Eidne K.A.; RT "Cloning and functional characterisation of the human TRH receptor."; RL Mol. Cell. Endocrinol. 95:R11-R15(1993). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=95002135; PubMed=7918619; RA Hinuma S., Hosoya M., Ogi K., Tanaka H., Nagai Y., Onda H.; RT "Molecular cloning and functional expression of a human thyrotropin- RT releasing hormone (TRH) receptor gene."; RL Biochim. Biophys. Acta 1219:251-259(1994). RN [5] RP SEQUENCE FROM N.A. RX MEDLINE=96355621; PubMed=8703031; RA Iwasaki T., Yamada M., Satoh T., Konaka S., Ren Y., Hashimoto K., RA Kohga H., Kato Y., Mori M.; RT "Genomic organization and promoter function of the human thyrotropin- RT releasing hormone receptor gene."; RL J. Biol. Chem. 271:22183-22188(1996). RN [6] RP SEQUENCE OF 1-263 FROM N.A. RC TISSUE=Placenta; RX MEDLINE=99101143; PubMed=9886052; RA Matre V., Hovring P.I., Orstavik S., Frengen E., Rian E., RA Velickovic Z., Murray-Mcintosh R.P., Gautvik K.M.; RT "Structural and functional organization of the gene encoding the RT human thyrotropin-releasing hormone receptor."; RL J. Neurochem. 72:40-50(1999). RN [7] RP DISULFIDE BOND. RX MEDLINE=96366792; PubMed=8770906; RA Cook J.V., McGregor A., Lee T., Milligan G., Eidne K.A.; RT "A disulfide bonding interaction role for cysteines in the RT extracellular domain of the thyrotropin-releasing hormone receptor."; RL Endocrinology 137:2851-2858(1996). CC -!- FUNCTION: RECEPTOR FOR THYROTROPIN-RELEASING HORMONE. THIS CC RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE A CC PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D16845; BAA04120.1; -. DR EMBL; X75071; CAA52965.1; -. DR EMBL; X72089; CAA50979.1; -. DR EMBL; S75283; AAB32222.1; -. DR EMBL; S75281; AAB32222.1; JOINED. DR EMBL; D85376; BAA12796.1; -. DR EMBL; D85375; BAA12796.1; JOINED. DR EMBL; AJ011701; CAA09746.1; -. DR PIR; S40682; JN0708. DR Genew; HGNC:12299; TRHR. DR MIM; 188545; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004997; F:thyrotropin-releasing hormone receptor acti...; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Polymorphism. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 51 1 (POTENTIAL). FT DOMAIN 52 61 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 62 83 2 (POTENTIAL). FT DOMAIN 84 99 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 100 121 3 (POTENTIAL). FT DOMAIN 122 144 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 145 168 4 (POTENTIAL). FT DOMAIN 169 193 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 194 215 5 (POTENTIAL). FT DOMAIN 216 266 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 267 288 6 (POTENTIAL). FT DOMAIN 289 296 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 297 319 7 (POTENTIAL). FT DOMAIN 320 398 CYTOPLASMIC (POTENTIAL). FT DISULFID 98 179 FT CARBOHYD 3 3 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 10 10 N-LINKED (GLCNAC...) (POTENTIAL). FT VARIANT 10 10 N -> K (in dbSNP:5774). FT /FTId=VAR_011857. SQ SEQUENCE 398 AA; 45084 MW; FE920B5F2E933D3E CRC64; MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW AFTSLYCMLW FFLLDLNIST YKDAIVISCG YKISRNYYSP IYLMDFGVFY VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH QNTNLNVNTS NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV ALNYSVIKES DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS // ID GHSR_HUMAN STANDARD; PRT; 366 AA. AC Q92847; Q92848; Q96RJ7; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing DE peptide receptor) (GHRP) (Ghrelin receptor). GN GHSR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORMS 1A AND 1B). RC TISSUE=Pituitary; RX MEDLINE=96337998; PubMed=8688086; RA Howard A.D., Feighner S.D., Cully D.F., Arena J.P., RA Liberator P.A., Rosenblum C.I., Hamelin M., Hreniuk D.L., RA Palyha O.C., Anderson J., Paress P.S., Diaz C., Chou M., Liu K.K., RA McKee K.K., Pong S.-S., Chaung L.-Y., Elbrecht A., Dashkevicz M., RA Heavens R., Rigby M., Sirinathsinghji D.J.S., Dean D.C., Melillo D.G., RA Patchett A.A., Nargund R., Griffin P.R., Demartino J.A., Gupta S.K., RA Schaeffer J.M., Smith R.G., van der Ploeg L.H.T.; RT "A receptor in pituitary and hypothalamus that functions in growth RT hormone release."; RL Science 273:974-977(1996). RN [2] RP SEQUENCE FROM N.A. (ISOFORMS 1A AND 1B). RX MEDLINE=21255649; PubMed=11356716; RA Petersenn S., Rasch A.C., Penshorn M., Beil F.U., Schulte H.M.; RT "Genomic structure and transcriptional regulation of the human growth RT hormone secretagogue receptor."; RL Endocrinology 142:2649-2659(2001). RN [3] RP SEQUENCE FROM N.A. (ISOFORM 1B). RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP FUNCTION. RX MEDLINE=21219832; PubMed=11322507; RA Smith R.G., Leonard R., Bailey A.R.T., Palyha O.C., Feighner S.D., RA Tan C.P., Mckee K.K., Pong S.-S., Griffin P.R., Howard A.D.; RT "Growth hormone secretagogue receptor family members and ligands."; RL Endocrine 14:9-14(2001). RN [5] RP FUNCTION. RX MEDLINE=20067959; PubMed=10604470; RA Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K.; RT "Ghrelin is a growth-hormone-releasing acylated peptide from RT stomach."; RL Nature 402:656-660(1999). CC -!- FUNCTION: Receptor for ghrelin, coupled to G-alpha-11 proteins. CC Stimulates growth hormone secretion. Binds also other growth CC hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) CC as well as non-peptide, low molecular weight secretagogues (e.g. CC L-692,429, MK-0677, adenosine). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1A; CC IsoId=Q92847-1; Sequence=Displayed; CC Name=1B; CC IsoId=Q92847-2; Sequence=VSP_001916, VSP_001917; CC -!- TISSUE SPECIFICITY: Pituitary and hypothalamus. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U60179; AAC50653.1; -. DR EMBL; U60181; AAC50654.1; -. DR EMBL; AF369786; AAK71539.1; -. DR EMBL; AF369786; AAK71540.1; -. DR EMBL; AY322544; AAP84357.1; -. DR Genew; HGNC:4267; GHSR. DR MIM; 601898; -. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Alternative splicing. FT DOMAIN 1 40 Extracellular (Potential). FT TRANSMEM 41 66 1 (Potential). FT DOMAIN 67 72 Cytoplasmic (Potential). FT TRANSMEM 73 96 2 (Potential). FT DOMAIN 97 117 Extracellular (Potential). FT TRANSMEM 118 139 3 (Potential). FT DOMAIN 140 162 Cytoplasmic (Potential). FT TRANSMEM 163 183 4 (Potential). FT DOMAIN 184 211 Extracellular (Potential). FT TRANSMEM 212 235 5 (Potential). FT DOMAIN 236 263 Cytoplasmic (Potential). FT TRANSMEM 264 285 6 (Potential). FT DOMAIN 286 302 Extracellular (Potential). FT TRANSMEM 303 326 7 (Potential). FT DOMAIN 327 366 Cytoplasmic (Potential). FT DISULFID 116 198 By similarity. FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 27 27 N-linked (GlcNAc...) (Potential). FT VARSPLIC 266 289 AVVVFAFILCWLPFHVGRYLFSKS -> GGSQRALRLSLAG FT PILSLCLLPSL (in isoform 1B). FT /FTId=VSP_001916. FT VARSPLIC 290 366 Missing (in isoform 1B). FT /FTId=VSP_001917. SQ SEQUENCE 366 AA; 41328 MW; D1B62710DA9DC0C6 CRC64; MWNATPSEEP GFNLTLADLD WDASPGNDSL GDELLQLFPA PLLAGVTATC VALFVVGIAG NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL VRLWQYRPWN FGDLLCKLFQ FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVIFVIWAV AFCSAGPIFV LVGVEHENGT DPWDTNECRP TEFAVRSGLL TVMVWVSSIF FFLPVFCLTV LYSLIGRKLW RRRRGDAVVG ASLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFRLLGF EPFSQRKLST LKDESSRAWT ESSINT // ID UL78_HCMVA STANDARD; PRT; 431 AA. AC P16751; DT 01-AUG-1990 (Rel. 15, Created) DT 01-AUG-1990 (Rel. 15, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Hypothetical protein UL78. GN UL78. OS Human cytomegalovirus (strain AD169). OC Viruses; dsDNA viruses, no RNA stage; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90269039; PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). CC -!- SUBCELLULAR LOCATION: Integral membrane protein (Potential). CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X17403; CAA35351.1; -. DR PIR; S09841; S09841. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; UNKNOWN_1. KW Hypothetical protein; Transmembrane. FT TRANSMEM 42 62 Potential. FT TRANSMEM 74 94 Potential. FT TRANSMEM 111 131 Potential. FT TRANSMEM 153 173 Potential. FT TRANSMEM 202 222 Potential. FT TRANSMEM 236 256 Potential. FT TRANSMEM 279 299 Potential. FT CARBOHYD 105 105 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 431 AA; 47357 MW; 34668FE7F908C657 CRC64; MSPSVEETTS VTESIMFAIV SFKHMGPFEG YSMSADRAAS DLLIGMFGSV SLVNLLTIIG CLWVLRVTRP PVSVMIFTWN LVLSQFFSIL ATMLSKGIML RGALNLSLCR LVLFVDDVGL YSTALFFLFL ILDRLSAISY GRDLWHHETR ENAGVALYAV AFAWVLSIVA AVPTAATGSL DYRWLGCQIP IQYAAVDLTI KMWFLLGAPM IAVLANVVEL AYSDRRDHVW SYVGRVCTFY VTCLMLFVPY YCFRVLRGVL QPASAAGTGF GIMDYVELAT RTLLTMRLGI LPLFIIAFFS REPTKDLDDS FDYLVERCQQ SCHGHFVRRL VQALKRAMYS VELAVCYFST SVRDVAEAVK KSSSRCYADA TSAAVVVTTT TSEKATLVEH AEGMASEMCP GTTIDVSAES SSVLCTDGEN TVASDATVTA L // ID EDG1_HUMAN STANDARD; PRT; 381 AA. AC P21453; DT 01-MAY-1991 (Rel. 18, Created) DT 01-MAY-1991 (Rel. 18, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Sphingosine 1-phosphate receptor Edg-1. GN EDG1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Umbilical vein endothelial cells; RX MEDLINE=90264425; PubMed=2160972; RA Hla T., Maciag T.; RT "An abundant transcript induced in differentiating human endothelial RT cells encodes a polypeptide with structural similarities to RT G-protein-coupled receptors."; RL J. Biol. Chem. 265:9308-9313(1990). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=98072391; PubMed=9409733; RA An S., Bleu T., Huang W., Hallmark O.G., Coughlin S.R., Goetzl E.J.; RT "Identification of cDNAs encoding two G protein-coupled receptors for RT lysosphingolipids."; RL FEBS Lett. 417:279-282(1997). RN [3] RP PHARMACOLOGICAL CHARATERIZATION. RX MEDLINE=96212194; PubMed=8626678; RA Lee M.-J., Evans M., Hla T.; RT "The inducible G protein-coupled receptor edg-1 signals via the RT G(i)/mitogen-activated protein kinase pathway."; RL J. Biol. Chem. 271:11272-11279(1996). RN [4] RP FUNCTION. RX MEDLINE=98155258; PubMed=9488656; RA Lee M.-J., Van Brocklyn J.R., Thangada S., Liu C.H., Hand A.R., RA Menzeleev R., Spiegel S., Hla T.; RT "Sphingosine-1-phosphate as a ligand for the G protein-coupled RT receptor EDG-1."; RL Science 279:1552-1555(1998). RN [5] RP PHARMACOLOGICAL CHARATERIZATION. RX PubMed=10383399; RA Ancellin N., Hla T.; RT "Differential pharmacological properties and signal transduction of RT the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5."; RL J. Biol. Chem. 274:18997-19002(1999). RN [6] RP PHOSPHORYLATION SITE THR-236, AND MUTAGENESIS OF THR-236. RX MEDLINE=21468402; PubMed=11583630; RA Lee M.-J., Thangada S., Paik J.-H., Sapkota G.P., Ancellin N., RA Chae S.-S., Wu M., Morales-Ruiz M., Sessa W.C., Alessi D.R., Hla T.; RT "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 RT is required for endothelial cell chemotaxis."; RL Mol. Cell 8:693-704(2001). RN [7] RP FUNCTION. RX MEDLINE=21143491; PubMed=11230698; RA Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., RA Caron M.G., Milstien S., Spiegel S.; RT "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced RT cell motility."; RL Science 291:1800-1803(2001). CC -!- FUNCTION: Receptor for the lysosphingolipid sphingosine 1- CC phosphate (S1P). S1P is a bioactive lysophospholipid that elicits CC diverse physiological effect on most types of cells and tissues. CC This inducible epithelial cell G-protein-coupled receptor may be CC involved in the processes that regulate the differentiation of CC endothelial cells. Seems to be coupled to the G(i) subclass of CC heteromeric G proteins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Endothelial cells, and to a lesser extent, in CC vascular smooth muscle cells, fibroblasts, melanocytes, and cells CC of epithelioid origin. CC -!- INDUCTION: By the tumor promoter phorbol 12-myristate 13-acetate CC (PME) in the presence of cycloheximide. CC -!- PTM: S1P-induced endothelial cell migration requires the PKB/AKT1- CC mediated phosphorylation of the third intracellular loop at CC the Thr-236 residue. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M31210; AAA52336.1; -. DR EMBL; AF022137; AAC51905.1; -. DR PIR; A35300; A35300. DR Genew; HGNC:3165; EDG1. DR MIM; 601974; -. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007155; P:cell adhesion; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR004061; S1P_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01523; S1PRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 46 Extracellular (Potential). FT TRANSMEM 47 71 1 (Potential). FT DOMAIN 72 78 Cytoplasmic (Potential). FT TRANSMEM 79 107 2 (Potential). FT DOMAIN 108 121 Extracellular (Potential). FT TRANSMEM 122 140 3 (Potential). FT DOMAIN 141 159 Cytoplasmic (Potential). FT TRANSMEM 160 185 4 (Potential). FT DOMAIN 186 201 Extracellular (Potential). FT TRANSMEM 202 222 5 (Potential). FT DOMAIN 223 255 Cytoplasmic (Potential). FT TRANSMEM 256 277 6 (Potential). FT DOMAIN 278 293 Extracellular (Potential). FT TRANSMEM 294 314 7 (Potential). FT DOMAIN 315 381 Cytoplasmic (Potential). FT CARBOHYD 30 30 N-linked (GlcNAc...) (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT LIPID 327 327 S-palmitoyl cysteine (By similarity). FT MOD_RES 236 236 Phosphothreonine (by PKB/AKT1). FT MOD_RES 352 352 Phosphoserine (Potential). FT MUTAGEN 236 236 T->A: Acts as a dominant negative GPCR FT and inhibits S1P-induced Rac activation, FT chemotaxis, and angiogenesis. SQ SEQUENCE 381 AA; 42695 MW; D706DA4C74C2E093 CRC64; MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKLTSV VFILICCFII LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNNFRL FLLISACWVI SLILGGLPIM GWNCISALSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN ISKASRSSEN VALLKTVIIV LSVFIACWAP LFILLLLDVG CKVKTCDILF RAEYFLVLAV LNSGTNPIIY TLTNKEMRRA FIRIMSCCKC PSGDSAGKFK RPIIAGMEFS RSKSDNSSHP QKDEGDNPET IMSSGNVNSS S // ID EDG2_SHEEP STANDARD; PRT; 393 AA. AC P46628; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Lysophosphatidic acid receptor Edg-2 (LPA receptor 1) (LPA-1). GN EDG2 OR EDG-2. OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Pituitary pars tuberalis; RX MEDLINE=96430916; PubMed=8833998; RA Masana M.I., Brown R.C., Pu H., Gurney M.E., Dubocovich M.L.; RT "Cloning and characterization of a new member of the G-protein RT coupled receptor EDG family."; RL Recept. Channels 3:255-262(1995). CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of CC diverse cellular activities. Seems to be coupled to the G(i)/G(0), CC G(12)/G(13), and G(q) families of heteromeric G proteins (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U18405; AAB52368.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR004065; LPA_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01527; LPARECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 50 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 51 75 1 (POTENTIAL). FT DOMAIN 76 82 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 83 111 2 (POTENTIAL). FT DOMAIN 112 125 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 126 144 3 (POTENTIAL). FT DOMAIN 145 163 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 164 189 4 (POTENTIAL). FT DOMAIN 190 205 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 206 226 5 (POTENTIAL). FT DOMAIN 227 258 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 259 280 6 (POTENTIAL). FT DOMAIN 281 294 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 295 315 7 (POTENTIAL). FT DOMAIN 316 393 CYTOPLASMIC (POTENTIAL). FT LIPID 327 327 S-palmitoyl cysteine (By similarity). FT CARBOHYD 27 27 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 35 35 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 393 AA; 44433 MW; 356E961153C345FC CRC64; MAAASTSSPV VSQPQFTAMN EPQCFYNESI AFFYNRSGKY LATEWNTVSK LVMGLGITVC IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST WLLRQGLIDT TVTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIENCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENTSGPTEG SDRSASSLNH TILAGVHSND HSVFRKETKM RGGHHLLRDE QPPPPERPGQ GRV // ID EDG4_MOUSE STANDARD; PRT; 348 AA. AC Q9JL06; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Lysophosphatidic acid receptor Edg-4 (LPA receptor 2) (LPA-2). GN EDG4 OR LPA2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=129/SvJ; RX MEDLINE=20195626; PubMed=10729222; RA Contos J.J.A., Chun J.; RT "Genomic characterization of the lysophosphatidic acid receptor gene, RT lp(A2)/Edg4, and identification of a frameshift mutation in a RT previously characterized cDNA."; RL Genomics 64:155-169(2000). RN [2] RP REVIEW. RX MEDLINE=20545693; PubMed=11093753; RA Contos J.J.A., Ishii I., Chun J.; RT "Lysophosphatidic acid receptors."; RL Mol. Pharmacol. 58:1188-1196(2000). CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of CC diverse cellular activities. Seems to be coupled to the G(i)/G(0), CC G(12)/G(13), and G(q) families of heteromeric G proteins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Most abundantly expressed in testes, kidney, CC and embryonic brain. Other organs also express the transcript, CC including heart, lung, spleen, thymus, stomach, and adult brain. CC Several have little or no expression, including liver, small CC intestine, and skeletal muscle. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF218844; AAF65684.1; -. DR MGD; MGI:1858422; Edg4. DR InterPro; IPR004066; EDG4_receptor. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR004065; LPA_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01528; EDG4RECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01527; LPARECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 30 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 31 51 1 (POTENTIAL). FT DOMAIN 52 66 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 67 87 2 (POTENTIAL). FT DOMAIN 88 104 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 105 124 3 (POTENTIAL). FT DOMAIN 125 144 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 145 165 4 (POTENTIAL). FT DOMAIN 166 185 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 186 206 5 (POTENTIAL). FT DOMAIN 207 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 260 6 (POTENTIAL). FT DOMAIN 261 270 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 271 291 7 (POTENTIAL). FT DOMAIN 292 348 CYTOPLASMIC (POTENTIAL). FT LIPID 308 308 S-palmitoyl cysteine (By similarity). FT CARBOHYD 7 7 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 15 15 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 348 AA; 38776 MW; E3594382D616052C CRC64; MGQCYYNETI GFFYNNSGKE LSLHWRPKDV VVVALGLTVS VLVLLTNLLV IAAIASNRRF HQPIYYLLGN LAAADLFAGM AYLFLMFHTG PPHCQALHQR LVPATGPAGH QPHGVSGHTA GIAVERHRSV MAVQLHSRLP RGRVVTLIVG VWAAALGLGL LPAHFWHCLC DLDSCSRMVP LFSRSYLAAW ALSSLLVFLL MVAVYTRIFF YVRRRVERMA EHVSCHPRYR ETTLSLVKTV VIILGAFVVC WTPGQVVLLL DGLDCKTCNV LAVEKYFLLL AEANSLVNAV VYSCRDAEMR RTFRRLLCCM CLRWSSHKSA RYSASAQTGA STRIMLPENG RPLMDSTL // ID L4R2_HUMAN STANDARD; PRT; 389 AA. AC Q9NPC1; Q9NPE5; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Leukotriene B4 receptor 2 (LTB4-R2) (Seven transmembrane receptor DE BLTR2) (Leukotriene B4 receptor BLT2) (LTB4 receptor JULF2). GN LTB4R2 OR BLT2R OR BLTR2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20374475; PubMed=10913346; RA Tryselius Y., Nilsson N.E., Kotarsky K., Olde B., Owman C.; RT "Cloning and characterization of cDNA encoding a novel human RT leukotriene B4 receptor."; RL Biochem. Biophys. Res. Commun. 274:377-382(2000). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=20394049; PubMed=10934230; RA Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.; RT "A second leukotriene B4 receptor, BLT2: a new therapeutic target in RT inflammation and immunological disorders."; RL J. Exp. Med. 192:421-432(2000). RN [3] RP SEQUENCE FROM N.A. RA Volpe F., Patel K., Barnes A., Sanseau P., Cousens D., Green A., RA Marshall F.; RT "Identification and characterisation of a novel LTB4 receptor."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE OF 32-389 FROM N.A. RX MEDLINE=20576218; PubMed=11006272; RA Wang S., Gustafson E., Pang L., Qiao X., Behan J., Maguire M., RA Bayne M., Laz T.; RT "A novel hepatointestinal leukotriene B4 receptor: cloning and RT functional characterization."; RL J. Biol. Chem. 275:40686-40694(2000). RN [6] RP SEQUENCE OF 32-389 FROM N.A. RX MEDLINE=20418070; PubMed=10889186; RA Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H., RA Furuichi K.; RT "Molecular cloning and characterization of another leukotriene B4 RT receptor."; RL J. Biol. Chem. 275:27000-27004(2000). RN [7] RP SEQUENCE OF 32-389 FROM N.A. RX MEDLINE=22040266; PubMed=12044878; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). CC -!- FUNCTION: Low-affinity receptor for leukotrienes including CC leukotriene B4. Mediates chemotaxis of granulocytes and CC macrophages. The response is mediated via G-proteins that activate CC a phosphatidylinositol-calcium second messenger system. The rank CC order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > CC LTB5 > LTB3. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Widely expressed. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- CAUTION: It is uncertain whether Met-1 or Met-32 is the initiator. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF277230; AAF81261.1; -. DR EMBL; AB029892; BAA99553.1; -. DR EMBL; AB008193; BAB00610.1; ALT_INIT. DR EMBL; AY268433; AAP23200.1; -. DR EMBL; AJ278605; CAB96134.1; -. DR EMBL; AF308571; AAG40857.1; -. DR EMBL; AB044402; BAA99539.1; -. DR EMBL; AB083604; BAB89317.1; -. DR PIR; JC7356; JC7356. DR Genew; HGNC:19260; LTB4R2. DR MIM; 605773; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003982; LTB2_receptor. DR InterPro; IPR003981; LTB_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01478; LTB2RECEPTOR. DR PRINTS; PR01476; LTBRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 55 Extracellular (Potential). FT TRANSMEM 56 76 1 (Potential). FT DOMAIN 77 91 Cytoplasmic (Potential). FT TRANSMEM 92 112 2 (Potential). FT DOMAIN 113 127 Extracellular (Potential). FT TRANSMEM 128 148 3 (Potential). FT DOMAIN 149 172 Cytoplasmic (Potential). FT TRANSMEM 173 193 4 (Potential). FT DOMAIN 194 216 Extracellular (Potential). FT TRANSMEM 217 237 5 (Potential). FT DOMAIN 238 256 Cytoplasmic (Potential). FT TRANSMEM 257 277 6 (Potential). FT DOMAIN 278 306 Extracellular (Potential). FT TRANSMEM 307 327 7 (Potential). FT DOMAIN 328 389 Cytoplasmic (Potential). FT CARBOHYD 41 41 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 389 AA; 41524 MW; 8D6BC5A73A42F544 CRC64; MAPSHRASQV GFCPTPERPL WRLPPTCRPR RMSVCYRPPG NETLLSWKTS RATGTAFLLL AALLGLPGNG FVVWSLAGWR PARGRPLAAT LVLHLALADG AVLLLTPLFV AFLTRQAWPL GQAGCKAVYY VCALSMYASV LLTGLLSLQR CLAVTRPFLA PRLRSPALAR RLLLAVWLAA LLLAVPAAVY RHLWRDRVCQ LCHPSPVHAA AHLSLETLTA FVLPFGLMLG CYSVTLARLR GARWGSGRHG ARVGRLVSAI VLAFGLLWAP YHAVNLLQAV AALAPPEGAL AKLGGAGQAA RAGTTALAFF SSSVNPVLYV FTAGDLLPRA GPRFLTRLFE GSGEARGGGR SREGTMELRT TPQLKVVGQG RGNGDPGGGM EKDGPEWDL // ID GP15_MACNE STANDARD; PRT; 360 AA. AC P56412; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE G protein-coupled receptor GPR15. GN GPR15. OS Macaca nemestrina (Pig-tailed macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9545; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97373958; PubMed=9230441; RA Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.; RT "Expression cloning of new receptors used by simian and human RT immunodeficiency viruses."; RL Nature 388:296-300(1997). CC -!- FUNCTION: Probable chemokine receptor. SIV-1 coreceptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF007857; AAB64223.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane. FT DOMAIN 1 33 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 34 54 1 (POTENTIAL). FT DOMAIN 55 69 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 70 90 2 (POTENTIAL). FT DOMAIN 91 120 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 121 141 3 (POTENTIAL). FT DOMAIN 142 149 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 150 170 4 (POTENTIAL). FT DOMAIN 171 192 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 193 213 5 (POTENTIAL). FT DOMAIN 214 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 260 6 (POTENTIAL). FT DOMAIN 261 284 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 285 305 7 (POTENTIAL). FT DOMAIN 306 360 CYTOPLASMIC (POTENTIAL). SQ SEQUENCE 360 AA; 40709 MW; 4CC9AA6C66F5292F CRC64; MDPEETSVYL DYYYATSPNP DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS VFLLTCMSVD RYLAIVCPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK PYCAEKKATP LKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI KIIFIVVAAF LVSWLPFNTS KLLAIVSGLQ QERYFPSAIL QLGMEVSGPL AFANSCVNPF IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF TRRRKRSVSL // ID GP15_MACFA STANDARD; PRT; 359 AA. AC Q9BDS7; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE G protein-coupled receptor GPR15. GN GPR15. OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21134756; PubMed=11242524; RA Wade-Evans A.M., Russell J., Jenkins A., Javan C.; RT "Cloning and sequencing of cynomolgus macaque ccr3, gpr15, and strl33: RT potential coreceptors for HIV type 1, HIV type 2, and SIV."; RL AIDS Res. Hum. Retroviruses 17:371-375(2001). CC -!- FUNCTION: Probable chemokine receptor. SIV-1 coreceptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF291670; AAK25741.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane. FT DOMAIN 1 33 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 34 54 1 (POTENTIAL). FT DOMAIN 55 69 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 70 90 2 (POTENTIAL). FT DOMAIN 91 120 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 121 141 3 (POTENTIAL). FT DOMAIN 142 149 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 150 170 4 (POTENTIAL). FT DOMAIN 171 192 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 193 213 5 (POTENTIAL). FT DOMAIN 214 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 260 6 (POTENTIAL). FT DOMAIN 261 283 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 284 304 7 (POTENTIAL). FT DOMAIN 305 359 CYTOPLASMIC (POTENTIAL). SQ SEQUENCE 359 AA; 40680 MW; CC2F212A94677981 CRC64; MDPEETSVYL DYYYATSPNP DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS VFLLTCMSVD RYLAIVCPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK PYCAEKKATP LKLIWSLVAL IFTFFVPLLN IVTCYCCIAR KLCAHYQQSG RHNKKLKKSI KIILIVVAAF LVSWLPFNTF KLLAIVSGLQ ERYFPSAMLQ LGMEVSGPLA FANSCVNPFI YYIFDSYIRR AIVHCLCPCL KNYDFGSSTE TSDSHLTKAL STFIHAEDFT RRRKRSVSL // ID P2YC_HUMAN STANDARD; PRT; 342 AA. AC Q9H244; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE P2Y purinoceptor 12 (P2Y12) (P2Y12 platelet ADP receptor) (P2Y(ADP)) DE (ADP-glucose receptor) (ADPG-R) (P2Y(AC)) (P2Y(cyc)) (P2T(AC)) DE (SP1999). GN P2RY12 OR HORK3. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21037966; PubMed=11196645; RA Hollopeter G., Jantzen H.-M., Vincent D., Li G., England L., RA Ramakrishnan V., Yang R.-B., Nurden P., Nurden A., Julius D.J., RA Conley P.B.; RT "Identification of the platelet ADP receptor targeted by RT antithrombotic drugs."; RL Nature 409:202-207(2001). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Hypothalamus; RX MEDLINE=21269433; PubMed=11104774; RA Zhang F.L., Luo L., Gustafson E., Lachowicz J., Smith M., Qiao X., RA Liu Y.-H., Chen G., Pramanik B., Laz T.M., Palmer K., Bayne M., RA Monsma F.J. Jr.; RT "ADP is the cognate ligand for the orphan G protein-coupled receptor RT SP1999."; RL J. Biol. Chem. 276:8608-8615(2001). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=21394281; PubMed=11502873; RA Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S.-I., RA Ohishi T., Soga T., Matsushime H., Furuichi K.; RT "Molecular cloning of the platelet P2T(AC) ADP receptor: RT pharmacological comparison with another ADP receptor, the P2Y1 RT receptor."; RL Mol. Pharmacol. 60:432-439(2001). RN [4] RP SEQUENCE FROM N.A. RA Reinscheid R.K., Nothacker H.-P., Wang Z., Zeng J., Ehlert F.J., RA Civelli O.; RT "ADP-glucose activates a G-protein coupled receptor and inhibits RT smooth muscle contractions."; RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE FROM N.A. RX MEDLINE=22040266; PubMed=12044878; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). RN [6] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. RN [7] RP SEQUENCE FROM N.A. RC TISSUE=Prostate; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for ADP and ATP coupled to G-proteins that CC inhibit the adenylyl cyclase second messenger system. Not CC activated by UDP and UTP. Involved in platelets aggregation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Highly expressed in the platelets, lower CC levels in the brain. Lowest levels in the lung, appendix, CC pituitary and adrenal gland. Expressed in the spinal cord and in CC the fetal brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF313449; AAG48944.1; -. DR EMBL; AF321815; AAK00948.1; -. DR EMBL; AB052684; BAB60824.1; -. DR EMBL; AF310685; AAL32292.1; -. DR EMBL; AB083596; BAB89309.1; -. DR EMBL; AY136754; AAN01280.1; -. DR EMBL; BC017898; AAH17898.1; -. DR Genew; HGNC:18124; P2RY12. DR MIM; 600515; -. DR GO; GO:0016020; C:membrane; NAS. DR GO; GO:0007599; P:hemostasis; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005394; P2Y12_purnocptor. DR InterPro; IPR008109; P2Y13_purnocptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01569; P2Y12PRNCPTR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT DOMAIN 80 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 142 Cytoplasmic (Potential). FT TRANSMEM 143 163 4 (Potential). FT DOMAIN 164 191 Extracellular (Potential). FT TRANSMEM 192 212 5 (Potential). FT DOMAIN 213 233 Cytoplasmic (Potential). FT TRANSMEM 234 254 6 (Potential). FT DOMAIN 255 281 Extracellular (Potential). FT TRANSMEM 282 302 7 (Potential). FT DOMAIN 303 342 Cytoplasmic (Potential). FT DISULFID 97 175 By similarity. FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 342 AA; 39438 MW; 8553D2746C89176D CRC64; MQAVDNLTSA PGNTSLCTRD YKITQVLFPL LYTVLFFVGL ITNGLAMRIF FQIRSKSNFI IFLKNTVISD LLMILTFPFK ILSDAKLGTG PLRTFVCQVT SVIFYFTMYI SISFLGLITI DRYQKTTRPF KTSNPKNLLG AKILSVVIWA FMFLLSLPNM ILTNRQPRDK NVKKCSFLKS EFGLVWHEIV NYICQVIFWI NFLIVIVCYT LITKELYRSY VRTRGVGKVP RKKVNVKVFI IIAVFFICFV PFHFARIPYT LSQTRDVFDC TAENTLFYVK ESTLWLTSLN ACLDPFIYFF LCKSFRNSLI SMLKCPNSAT SLSQDNRKKE QDGGDPNEET PM // ID PS24_XENLA STANDARD; PRT; 372 AA. AC P79945; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE High-affinity lysophosphatidic acid receptor (PSP24). OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus. OX NCBI_TaxID=8355; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Oocyte; RX MEDLINE=97121391; PubMed=8962057; RA Guo Z., Liliom K., Fischer D.J., Bathurst I.C., Tomei L.D., RA Kiefer M.C., Tigyi G.; RT "Molecular cloning of a high-affinity receptor for the growth factor- RT like lipid mediator lysophosphatidic acid from Xenopus oocytes."; RL Proc. Natl. Acad. Sci. U.S.A. 93:14367-14372(1996). CC -!- FUNCTION: Highly selective receptor for lysophosphatidic acid CC (LPA), a mediator of diverse cellular activities. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Ubiquitously expressed. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U76385; AAB37322.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 59 1 (POTENTIAL). FT DOMAIN 60 80 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 81 101 2 (POTENTIAL). FT DOMAIN 102 108 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 109 129 3 (POTENTIAL). FT DOMAIN 130 149 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 150 170 4 (POTENTIAL). FT DOMAIN 171 198 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 199 219 5 (POTENTIAL). FT DOMAIN 220 268 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 269 289 6 (POTENTIAL). FT DOMAIN 290 301 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 302 324 7 (POTENTIAL). FT DOMAIN 325 372 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 15 15 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 372 AA; 42253 MW; 888FFA4105D592C9 CRC64; MGCNNTALDN CMLPNLSIAT APLDLRFAFS TPLRMLLAII MILMIAIAFL GNAIVCLIVY QKPAMRSAIN LLLATLAFSD IMLSLFCMPF TAVTIITGSW LFGTQFCQIS AMLYWFFVLE GVAILLIISV DRFLIIVQRQ DKLNPHRAKI MIAASWVLSF CISLPSVVGW TLVEVPTRAP QCVLGYTEFS ADRVYAVMLI VAVFFIPFSV MLYSYLCILN TVRRNAVRIH THADSLCLSQ VSKLGLMGLQ RPHQMNVDMS FKTRAFTTIL ILFIGFSLCW LPHSVFSLLS VFSRTFYYSS SFYSISTCTL WLTYLKSVFN PVIYCWRIKK FREACLEFMP KTFKILPNVR GRTRRRIRPS TIYVCGEHQS AV // ID GP10_RAT STANDARD; PRT; 370 AA. AC Q64121; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G DE protein-coupled receptor GPR10) (UHR-1). GN GPR10. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Hypothalamus; RX MEDLINE=95251659; PubMed=7733930; RA Welch S.K., O'Hara B.F., Kilduff T.S., Heller H.C.; RT "Sequence and tissue distribution of a candidate G-coupled receptor RT cloned from rat hypothalamus."; RL Biochem. Biophys. Res. Commun. 209:606-613(1995). RN [2] RP TISSUE SPECIFICITY. RX MEDLINE=99426652; PubMed=10498338; RA Fujii R., Fukusumi S., Hosoya M., Kawamata Y., Habata Y., Hinuma S., RA Sekiguchi M., Kitada C., Kurokawa T., Nishimura O., Onda H., RA Sumino Y., Fujino M.; RT "Tissue distribution of prolactin-releasing peptide (PrRP) and its RT receptor."; RL Regul. Pept. 83:1-10(1999). CC -!- FUNCTION: Receptor for prolactin-releasing peptide (PrRP). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in CC pituitary, cerebellum, and hypothalamus. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S77867; AAB34129.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 62 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 63 83 1 (POTENTIAL). FT DOMAIN 84 101 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 102 122 2 (POTENTIAL). FT DOMAIN 123 126 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 127 147 3 (POTENTIAL). FT DOMAIN 148 175 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 176 196 4 (POTENTIAL). FT DOMAIN 197 223 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 224 244 5 (POTENTIAL). FT DOMAIN 245 276 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 277 297 6 (POTENTIAL). FT DOMAIN 298 317 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 318 338 7 (POTENTIAL). FT DOMAIN 339 370 CYTOPLASMIC (POTENTIAL). FT DISULFID 134 211 BY SIMILARITY. FT CARBOHYD 27 27 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 36 36 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 370 AA; 41160 MW; 8EE5E689D127CB2C CRC64; MTSLPPGTTG DPDLFSGPSP AGSTPANQSA EASESNVSAT VPRAAAVTPF QSLQLVHQLK GLIVMLYSIV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG NLALSDVLMC AACVPLTLAY AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF TLTTIAVDRY VVLVHPLRRR ISLKLSAYAV LGIWALSAVL ALPAAVHTYH VELKPHDVRL CEEFWGSQER QRQIYAWGLL LGTYLLPLLA ILLSYVRVSV KLRNRVVPGS VTQSQADWDR ARRRRTFCLL VVVVVVFALC WLPLHIFNLL RDLDPRAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKML LSWPRKIVPH GQNMTVSVVI // ID GP86_HUMAN STANDARD; PRT; 333 AA. AC Q9BPV8; Q8IUT5; Q8TDU7; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Probable G protein-coupled receptor GPR86 (P2Y purinoceptor 13) DE (P2Y13) (FKSG77 protein). GN GPR86 OR GPR94 OR FKSG77. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Amygdala, Caudate, Fetal brain, and Placenta; RX MEDLINE=21172992; PubMed=11273702; RA Wittenberger T., Schaller H.C., Hellebrand S.; RT "An expressed sequence tag (EST) data mining strategy succeeding in RT the discovery of new G-protein coupled receptors."; RL J. Mol. Biol. 307:799-813(2001). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21458557; PubMed=11574155; RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.; RT "Discovery and mapping of ten novel G protein-coupled receptor RT genes."; RL Gene 275:83-91(2001). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Spleen; RX MEDLINE=21538899; PubMed=11546776; RA Communi D., Gonzalez N.S., Detheux M., Brezillon S., Lannoy V., RA Parmentier M., Boeynaems J.-M.; RT "Identification of a novel human ADP receptor coupled to Gi."; RL J. Biol. Chem. 276:41479-41485(2001). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=22040266; PubMed=12044878; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Heart; RA Wang Y.-G., Gong L.; RT "Molecular cloning of FKSG77, a novel gene encoding a putative G- RT protein-coupled receptor."; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. Seems to be a G(i)-coupled receptor CC displaying a high affinity for ADP. Might play a role in CC hematopoiesis and the immune system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Strong expression in spleen and adult brain. CC Lower expression in placenta, lung, liver, spinal cord, thymus, CC small intestine, uterus, stomach, testis, fetal brain, and adrenal CC gland. Not detected in pancreas, heart, kidney, skeletal muscle, CC ovary or fetal aorta. Clearly detected in lymph node and bone CC marrow, weakly detected in peripheral blood mononuclear cells CC (PBMC) and in peripheral blood leukocytes (PBL), but not detected CC in polymorphonuclear cells (PMN). In the brain, detected in all CC brain regions examined. CC -!- MISCELLANEOUS: Stimulation by ADP in stably transfected CHO cells CC resulted in inhibition of adenylyl cyclase and the phosphorylation CC of the MAP kinases MAPK3 and MAPK1 in a pertusis toxin-sensitive CC way. Inhibition of adenylyl cyclase and phosphorylation of the MAP CC kinases are transduction mechanisms that involve G(i) proteins. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF295368; AAK01864.1; -. DR EMBL; AF411113; AAL26484.1; -. DR EMBL; AF406692; AAL01038.1; -. DR EMBL; AB083597; BAB89310.1; -. DR EMBL; AF345565; AAK29068.1; -. DR EMBL; BC041116; AAH41116.2; -. DR Genew; HGNC:4537; GPR86. DR MIM; 606380; -. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0016526; F:G-protein coupled receptor activity, unknow...; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008109; P2Y13_purnocptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01735; P2Y13PRNCPTR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 28 Extracellular (Potential). FT TRANSMEM 29 49 1 (Potential). FT DOMAIN 50 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 96 Extracellular (Potential). FT TRANSMEM 97 117 3 (Potential). FT DOMAIN 118 140 Cytoplasmic (Potential). FT TRANSMEM 141 161 4 (Potential). FT DOMAIN 162 190 Extracellular (Potential). FT TRANSMEM 191 211 5 (Potential). FT DOMAIN 212 231 Cytoplasmic (Potential). FT TRANSMEM 232 252 6 (Potential). FT DOMAIN 253 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 333 Cytoplasmic (Potential). FT DISULFID 95 173 By similarity. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 264 264 N-linked (GlcNAc...) (Potential). FT CONFLICT 158 158 M -> T (in Ref. 4). SQ SEQUENCE 333 AA; 38440 MW; F234ABB50016DF34 CRC64; MNTTVMQGFN RSERCPRDTR IVQLVFPALY TVVFLTGILL NTLALWVFVH IPSSSTFIIY LKNTLVADLI MTLMLPFKIL SDSHLAPWQL RAFVCRFSSV IFYETMYVGI VLLGLIAFDR FLKIIRPLRN IFLKKPVFAK TVSIFIWFFL FFISLPNMIL SNKEATPSSV KKCASLKGPL GLKWHQMVNN ICQFIFWTVF ILMLVFYVVI AKKVYDSYRK SKSKDRKNNK KLEGKVFVVV AVFFVCFAPF HFARVPYTHS QTNNKTDCRL QNQLFIAKET TLFLAATNIC MDPLIYIFLC KKFTEKLPCM QGRKTTASSQ ENHSSQTDNI TLG // ID P2YX_RAT STANDARD; PRT; 305 AA. AC O35881; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE UDP-glucose receptor (G protein-coupled receptor GPR105) (VTR 15-20). GN GPR105. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97439647; PubMed=9295203; RA Charlton M.E., Williams A.S., Fogliano M., Sweetnam P.M., Duman R.S.; RT "The isolation and characterization of a novel G protein-coupled RT receptor regulated by immunologic challenge."; RL Brain Res. 764:141-148(1997). CC -!- FUNCTION: Receptor for UDP-glucose coupled to G-proteins (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U76206; AAB71745.1; -. DR GO; GO:0016021; C:integral to membrane; ISS. DR GO; GO:0045029; F:UDP-activated nucleotide receptor activity; ISS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; ISS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005466; UDPG_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01655; UDPGLUCOSER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 29 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 30 50 1 (POTENTIAL). FT DOMAIN 51 55 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 56 76 2 (POTENTIAL). FT DOMAIN 77 96 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 97 117 3 (POTENTIAL). FT DOMAIN 118 139 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 140 160 4 (POTENTIAL). FT DOMAIN 161 188 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 189 209 5 (POTENTIAL). FT DOMAIN 210 234 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 235 255 6 (POTENTIAL). FT DOMAIN 256 278 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 279 299 7 (POTENTIAL). FT DOMAIN 300 305 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 3 3 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 161 161 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 305 AA; 34800 MW; 640646A68ECCC7A3 CRC64; MDNTTTTEPP KQPCTRNTLI TQQIIPMLYC VVFITGVLLN GISGWIFFYV PSSKSFIIYL KNIVVADFLM GLTFPFKVLS DSGLGPWQLN VFVFRVSAVI FYVNMYVSIA FFGLISFDRY YKIVKPLLVS IVQSVNYSKV LSVLVWVLML LLAVPNIILT NQSVKDVTNI QCMELKNELG RKWHKASNYV FVSIFWIVFL LLTVFYMAIT RKIFKSHLKS RKNSISVKRK SSRNIFSIVL AFVACFAPYH VARIPYTKSQ TEGHYSCQAK ETLLYTKEFT LLLSAANVCL DPISISSYAS RLEKS // ID MRG_HUMAN STANDARD; PRT; 378 AA. AC P35410; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Mas-related G protein-coupled receptor MRG (MAS-R) (MAS1-like). GN MAS1L OR MRG. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=92130997; PubMed=1723144; RA Monnot C., Weber V., Stinnakre J., Bihoreau C., Teutsch B., Corvol P., RA Clauser E.; RT "Cloning and functional characterization of a novel mas-related gene, RT modulating intracellular angiotensin II actions."; RL Mol. Endocrinol. 5:1477-1487(1991). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Mas subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S78653; AAB21255.1; -. DR EMBL; AL035542; CAB44503.1; -. DR EMBL; BC069127; AAH69127.1; -. DR PIR; A39485; A39485. DR Genew; HGNC:13961; MAS1L. DR MIM; 607235; -. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; NAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 77 Extracellular (Potential). FT TRANSMEM 78 101 1 (Potential). FT DOMAIN 102 109 Cytoplasmic (Potential). FT TRANSMEM 110 136 2 (Potential). FT DOMAIN 137 154 Extracellular (Potential). FT TRANSMEM 155 169 3 (Potential). FT DOMAIN 170 191 Cytoplasmic (Potential). FT TRANSMEM 192 207 4 (Potential). FT DOMAIN 208 221 Extracellular (Potential). FT TRANSMEM 222 248 5 (Potential). FT DOMAIN 249 264 Cytoplasmic (Potential). FT TRANSMEM 265 286 6 (Potential). FT DOMAIN 287 297 Extracellular (Potential). FT TRANSMEM 298 317 7 (Potential). FT DOMAIN 318 378 Cytoplasmic (Potential). FT CARBOHYD 54 54 N-linked (GlcNAc...) (Potential). FT CARBOHYD 57 57 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 378 AA; 42410 MW; E08A606294B61474 CRC64; MVWGKICWFS QRAGWTVFAE SQISLSCSLC LHSGDQEAQN PNLVSQLCGV FLQNETNETI HMQMSMAVGQ QALPLNIIAP KAVLVSLCGV LLNGTVFWLL CCGATNPYMV YILHLVAADV IYLCCSAVGF LQVTLLTYHG VVFFIPDFLA ILSPFSFEVC LCLLVAISTE RCVCVLFPIW YRCHRPKYTS NVVCTLIWGL PFCINIVKSL FLTYWKHVKA CVIFLKLSGL FHAILSLVMC VSSLTLLIRF LCCSQQQKAT RVYAVVQISA PMFLLWALPL SVAPLITDFK MFVTTSYLIS LFLIINSSAN PIIYFFVGSL RKKRLKESLR VILQRALADK PEVGRNKKAA GIDPMEQPHS TQHVENLLPR EHRVDVET // ID GPR6_HUMAN STANDARD; PRT; 362 AA. AC P46095; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Probable G protein-coupled receptor GPR6. GN GPR6. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95134353; PubMed=7832990; RA Heiber M., Docherty J.M., Shah G., Nguyen T., Cheng R., RA Heng H.H.Q., Marchese A., Tsui L.-C., Shi X., George S.R., RA O'Dowd B.F.; RT "Isolation of three novel human genes encoding G protein-coupled RT receptors."; RL DNA Cell Biol. 14:25-35(1995). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=96015070; PubMed=8530049; RA Song Z.-H., Modi W., Bonner T.I.; RT "Molecular cloning and chromosomal localization of human genes RT encoding three closely related G protein-coupled receptors."; RL Genomics 28:347-349(1995). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L36150; AAA63181.1; -. DR EMBL; U18549; AAA91631.1; -. DR EMBL; BC043414; -; NOT_ANNOTATED_CDS. DR PIR; I65990; I65990. DR Genew; HGNC:4515; GPR6. DR MIM; 600553; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 74 Extracellular (Potential). FT TRANSMEM 75 94 1 (Potential). FT DOMAIN 95 106 Cytoplasmic (Potential). FT TRANSMEM 107 130 2 (Potential). FT DOMAIN 131 142 Extracellular (Potential). FT TRANSMEM 143 164 3 (Potential). FT DOMAIN 165 185 Cytoplasmic (Potential). FT TRANSMEM 186 205 4 (Potential). FT DOMAIN 206 230 Extracellular (Potential). FT TRANSMEM 231 249 5 (Potential). FT DOMAIN 250 277 Cytoplasmic (Potential). FT TRANSMEM 278 304 6 (Potential). FT DOMAIN 305 309 Extracellular (Potential). FT TRANSMEM 310 331 7 (Potential). FT DOMAIN 332 362 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 51 51 N-linked (GlcNAc...) (Potential). FT LIPID 345 345 S-palmitoyl cysteine (By similarity). FT DISULFID 216 299 By similarity. FT MOD_RES 356 356 Phosphoserine (Potential). FT MOD_RES 358 358 Phosphoserine (Potential). FT MOD_RES 360 360 Phosphoserine (Potential). FT DOMAIN 13 16 Poly-Val. FT DOMAIN 21 28 Poly-Ala. FT DOMAIN 40 43 Poly-Ala. SQ SEQUENCE 362 AA; 37881 MW; AF8C6075603337AD CRC64; MNASAASLND SQVVVVAAEG AAAAATAAGG PDTGEWGPPA AAALGAGGGA NGSLELSSQL SAGPPGLLLP AVNPWDVLLC VSGTVIAGEN ALVVALIAST PALRTPMFVL VGSLATADLL AGCGLILHFV FQYLVPSETV SLLTVGFLVA SFAASVSSLL AITVDRYLSL YNALTYYSRR TLLGVHLLLA ATWTVSLGLG LLPVLGWNCL AERAACSVVR PLARSHVALL SAAFFMVFGI MLHLYVRICQ VVWRHAHQIA LQQHCLAPPH LAATRKGVGT LAVVLGTFGA SWLPFAIYCV VGSHEDPAVY TYATLLPATY NSMINPIIYA FRNQEIQRAL WLLLCGCFQS KVPFRSRSPS EV // ID SRB3_HUMAN STANDARD; PRT; 373 AA. AC Q9NS66; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Super conserved receptor expressed in brain 3. GN SREB3. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=20294882; PubMed=10833454; RA Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., RA Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.; RT "An evolutionarily conserved G-protein coupled receptor family, SREB, RT expressed in the central nervous system."; RL Biochem. Biophys. Res. Commun. 272:576-582(2000). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity). CC -!- TISSUE SPECIFICITY: Expressed at high levels in brain and ovary. CC Lower levels in small intestine. In brain regions, detected in all CC regions tested. Highest levels in the cerebellum and cerebral CC cortex. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB040801; BAA96647.1; -. DR EMBL; BC009861; AAH09861.1; -. DR PIR; JC7289; JC7289. DR MIM; 300253; -. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 26 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 27 47 1 (POTENTIAL). FT DOMAIN 48 59 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 60 80 2 (POTENTIAL). FT DOMAIN 81 97 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 98 118 3 (POTENTIAL). FT DOMAIN 119 139 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 140 160 4 (POTENTIAL). FT DOMAIN 161 188 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 189 209 5 (POTENTIAL). FT DOMAIN 210 287 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 288 308 6 (POTENTIAL). FT DOMAIN 309 322 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 323 343 7 (POTENTIAL). FT DOMAIN 344 373 CYTOPLASMIC (POTENTIAL). FT DISULFID 96 174 BY SIMILARITY. FT CARBOHYD 3 3 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 184 184 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 373 AA; 41481 MW; 8A227F914C9D8358 CRC64; MANTTGEPEE VSGALSPPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE RALHKAPYYF LLDLCLADGI RSAVCFPFVL ASVRHGSSWT FSALSCKIVA FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC LRTHAPCWGT GGAPAPREPY CVM // ID GP27_RAT STANDARD; PRT; 377 AA. AC Q9JJH3; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Probable G protein-coupled receptor GPR27 (Super conserved receptor DE expressed in brain 1). GN GPR27 OR SREB1. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=20294882; PubMed=10833454; RA Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., RA Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.; RT "An evolutionarily conserved G-protein coupled receptor family, SREB, RT expressed in the central nervous system."; RL Biochem. Biophys. Res. Commun. 272:576-582(2000). RN [2] RP TISSUE SPECIFICITY. RX MEDLINE=98140132; PubMed=9479505; RA O'Dowd B.F., Nguyen T., Marchese A., Cheng R., Lynch K.R., RA Heng H.H.Q., Kolakowski L.F. Jr., George S.R.; RT "Discovery of three novel G-protein-coupled receptor genes."; RL Genomics 47:310-313(1998). CC -!- FUNCTION: Orphan receptor. Possible candidate for amine-like G- CC protein coupled receptor (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity). CC -!- TISSUE SPECIFICITY: Expressed as a 3.0 kb transcript, in whole CC brain, hippocampus, striatum, frontal cortex, thalamus, pons and CC hypothalamus. A lower molecular weight transcript was detected in CC all regions examined, except the hypothalamus. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB040802; BAA96648.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 24 Extracellular (Potential). FT TRANSMEM 25 45 1 (Potential). FT DOMAIN 46 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT DOMAIN 120 140 Cytoplasmic (Potential). FT TRANSMEM 141 161 4 (Potential). FT DOMAIN 162 183 Extracellular (Potential). FT TRANSMEM 184 204 5 (Potential). FT DOMAIN 205 287 Cytoplasmic (Potential). FT TRANSMEM 288 308 6 (Potential). FT DOMAIN 309 322 Extracellular (Potential). FT TRANSMEM 323 343 7 (Potential). FT DOMAIN 344 377 Cytoplasmic (Potential). FT DISULFID 96 173 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 377 AA; 39892 MW; EC32C271C982D47B CRC64; MANASEPGGG GGGAEAAALG LRLATLSLLL CVSLAGNVLF ALLIVRERSL HRAPYYLLLD LCLADGLRAL ACLPAVMLAA RRAAAAAGTP PGALGCKLLA FLAALFCFHA AFLLLGVGVT RYLAIAHHRF YAERLAGWPC AAMLVCAAWA LALAAAFPPV LDGGGADDED APCALEQRPD GAPGALGFLL LLAAVVGATH LVYLRLLFFI HDRRKMRPAR LVPAVSHDWT FHGPGATGQA AANWTAGFGR GPTPPALVGI RPAGPGRGAR RLLVLEEFKT EKRLCKMFYA ITLLFLLLWG PYVVASYLRV LVRPGAVPQA YLTASVWLTF AQAGINPVVC FLFNRELRDC FRAQFPCCQS PQATQATLPC DLKGIGL // ID LGR4_RAT STANDARD; PRT; 951 AA. AC Q9Z2H4; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Leucine-rich repeat-containing G protein-coupled receptor 4 precursor. GN GPR48 OR LGR4. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Ovary; RX MEDLINE=99065210; PubMed=9849958; RA Hsu S.Y., Liang S.-G., Hsueh A.J.W.; RT "Characterization of two LGR genes homologous to gonadotropin and RT thyrotropin receptors with extracellular leucine-rich repeats and a G RT protein-coupled, seven-transmembrane region."; RL Mol. Endocrinol. 12:1830-1845(1998). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -!- SIMILARITY: Contains 15 leucine-rich (LRR) repeats. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF061443; AAC77910.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001611; LRR. DR InterPro; IPR000372; LRR_Nterm. DR InterPro; IPR003591; LRR_typ. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF00560; LRR; 15. DR Pfam; PF01462; LRRNT; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00019; LEURICHRPT. DR SMART; SM00369; LRR_TYP; 5. DR SMART; SM00013; LRRNT; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Signal; Glycoprotein; KW Repeat; Leucine-rich repeat. FT SIGNAL 1 24 POTENTIAL. FT CHAIN 25 951 LEUCINE-RICH REPEAT-CONTAINING G PROTEIN- FT COUPLED RECEPTOR 4. FT DOMAIN 25 544 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 545 565 1 (POTENTIAL). FT DOMAIN 566 575 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 576 596 2 (POTENTIAL). FT DOMAIN 597 619 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 620 640 3 (POTENTIAL). FT DOMAIN 641 661 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 662 682 4 (POTENTIAL). FT DOMAIN 683 703 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 704 724 5 (POTENTIAL). FT DOMAIN 725 756 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 757 777 6 (POTENTIAL). FT DOMAIN 778 783 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 784 804 7 (POTENTIAL). FT DOMAIN 805 951 CYTOPLASMIC (POTENTIAL). FT REPEAT 55 79 LRR 1. FT REPEAT 81 103 LRR 2. FT REPEAT 104 127 LRR 3. FT REPEAT 128 151 LRR 4. FT REPEAT 153 175 LRR 5. FT REPEAT 176 199 LRR 6. FT REPEAT 200 223 LRR 7. FT REPEAT 225 247 LRR 8. FT REPEAT 248 270 LRR 9. FT REPEAT 272 294 LRR 10. FT REPEAT 318 341 LRR 11. FT REPEAT 342 366 LRR 12. FT REPEAT 368 387 LRR 13. FT REPEAT 388 411 LRR 14. FT REPEAT 413 435 LRR 15. FT DISULFID 618 693 BY SIMILARITY. FT CARBOHYD 68 68 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 188 188 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 199 199 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 294 294 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 314 314 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 505 505 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 951 AA; 104138 MW; EDD56AC072123461 CRC64; MPGPLGLLCF LALGLLGSAG PSGAAPPLCA APCSCDGDRR VDCSGKGLTA VPEGLSAFTQ ALDISMNNIT QLPEDAFKSF PFLEELQLAG NDLSLIHPKA LSGLKELKVL TLQNNQLRTV PSEAIHGLSA LQSLRLDANH ITSVPEDSFE GLVQLRHLWL DDNSLTEVPV RPLSNLPTLQ ALTLALNNIS SIPDFAFTNL SSLVVLHLHN NKIKSLSQHC FDGLDNLETL DLNYNYLDEF PQAIKALPSL KELGFHSNSI SVIPDGAFGG NPLLRTIHLY DNPLSFVGNS AFHNLSDLHC LVIRGASLVQ WFPNLTGTVH LESLTLTGTK ISSIPDDLCQ NQKMLRTLDL SYNNIRDLPS FNGCRALEEI SLQRNQISLI KENTFQGLTS LRILDLSRNL IREIHSGAFA KLGTITNLDV SFNELTSFPT EGLNGLNQLK LVGNFKLKDA LAARDFANLR SLSVPYAYQC CAFWGCDSYA NLNTEDNSPQ EHSVTKEKGA TDAANVTSTA ENEEHSQIII HCTPSTGAFK PCEYLLGSWM IRLTVWFIFL VALLFNLLVI LTVFASCSSL PASKLFIGLI SVSNLLMGIY TGILTFLDAV SWGRFAEFGI WWETGSGCKV AGSLAVFSSE SAVFLLTLAA VERSVFAKDL MKHGKSSHLR QFQVAALLAL LGAAVAGCFP LFHGGQYSAS PLCLPFPTGE TPSLGFTVTL VLLNSLAFLL MAIIYTKLYC NLEKEDLSEN SQSSVIKHVA WLIFTNCIFF CPVAFFSFAP LITAISISPE IMKSVTLIFF PLPACLNPVL YVFFNPKFKE DWKLLKRRVT RKHGSVSVSI SSQGGCGEQD FYYDCGMYSH LQGNLTVCDC CESFLLTKPV SCKHLIKSHS CPVLTAASCQ RPEAYWSDCG TQSAHSDYAD EEDSFVSDSS DQVQACGRAC FYQSRGFPLV RYAYNLQRVR D // ID GP40_HUMAN STANDARD; PRT; 300 AA. AC O14842; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Putative G protein-coupled receptor GPR40. GN GPR40. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98008875; PubMed=9344866; RA Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., RA O'Dowd B.F.; RT "A cluster of four novel human G protein-coupled receptor genes RT occurring in close proximity to CD22 gene on chromosome 19q13.1."; RL Biochem. Biophys. Res. Commun. 239:543-547(1997). CC -!- FUNCTION: ORPHAN RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF024687; AAB86710.1; -. DR Genew; HGNC:4498; GPR40. DR MIM; 603820; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane. FT DOMAIN 1 10 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 11 31 1 (POTENTIAL). FT DOMAIN 32 42 CYTOPLASMIC. FT TRANSMEM 43 63 2 (POTENTIAL). FT DOMAIN 64 81 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 82 102 3 (POTENTIAL). FT DOMAIN 103 123 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 124 144 4 (POTENTIAL). FT DOMAIN 145 178 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 179 197 5 (POTENTIAL). FT DOMAIN 198 221 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 222 242 6 (POTENTIAL). FT DOMAIN 243 258 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 259 279 7 (POTENTIAL). FT DOMAIN 280 300 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 155 155 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 300 AA; 31457 MW; 77EF27DACD93E80B CRC64; MDLPPQLSFG LYVAAFALGF PLNVLAIRGA TAHARLRLTP SLVYALNLGC SDLLLTVSLP LKAVEALASG AWPLPASLCP VFAVAHFFPL YAGGGFLAAL SAGRYLGAAF PLGYQAFRRP CYSWGVCAAI WALVLCHLGL VFGLEAPGGW LDHSNTSLGI NTPVNGSPVC LEAWDPASAG PARFSLSLLL FFLPLAITAF CYVGCLRALA RSGLTHRRKL RAAWVAGGAL LTLLLCVGPY NASNVASFLY PNLGGSWRKL GLITGAWSVV LNPLVTGYLG RGPGLKTVCA ARTQGGKSQK //