ID A2AC_MOUSE STANDARD; PRT; 458 AA. AC Q01337; DT 01-APR-1993 (Rel. 25, Created) DT 01-APR-1993 (Rel. 25, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C DE adrenoreceptor) (Subtype C4). GN ADRA2C. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=92342131; PubMed=1353249; RA Link R.E., Daunt D.A., Barsh G., Chruscinski A.J., Kobilka B.K.; RT "Cloning of two mouse genes encoding alpha 2-adrenergic receptor RT subtypes and identification of a single amino acid in the mouse alpha RT 2-C10 homolog responsible for an interspecies variation in RT antagonist binding."; RL Mol. Pharmacol. 42:16-27(1992). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=DBA/2; RX MEDLINE=93250567; PubMed=8387367; RA Chang Y.-H., Chang A.C., Chen W.-M., Chang N.-C.A.; RT "Molecular characterization of a murine homologue of alpha 2C4 RT adrenoceptor subtype gene."; RL Biochem. Mol. Biol. Int. 29:467-474(1993). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M99376; AAA37212.1; -. DR EMBL; M97516; AAA37183.1; -. DR PIR; A48392; A48392. DR PIR; I49480; I49480. DR HSSP; P08913; 1HLL. DR MGD; MGI:87936; Adra2c. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00560; ADRENRGCA2CR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation. FT DOMAIN 1 51 Extracellular (Potential). FT TRANSMEM 52 76 1 (Potential). FT DOMAIN 77 88 Cytoplasmic (Potential). FT TRANSMEM 89 114 2 (Potential). FT DOMAIN 115 124 Extracellular (Potential). FT TRANSMEM 125 147 3 (Potential). FT DOMAIN 148 168 Cytoplasmic (Potential). FT TRANSMEM 169 191 4 (Potential). FT DOMAIN 192 207 Extracellular (Potential). FT TRANSMEM 208 231 5 (Potential). FT DOMAIN 232 379 Cytoplasmic (Potential). FT TRANSMEM 380 403 6 (Potential). FT DOMAIN 404 416 Extracellular (Potential). FT TRANSMEM 417 437 7 (Potential). FT DOMAIN 438 458 Cytoplasmic (Potential). FT DOMAIN 291 305 Arg-rich (basic). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT DISULFID 124 202 By similarity. FT CONFLICT 196 196 G -> V (in Ref. 2). FT CONFLICT 296 296 G -> A (in Ref. 2). FT CONFLICT 298 298 L -> V (in Ref. 2). SQ SEQUENCE 458 AA; 49906 MW; C0A8BDF0302BF1FB CRC64; MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWV PPPGQYSAGA VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSF YRRPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRGP AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE FFLSRRRRAR SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL YGICREACQL PEPLFKFFFW IGYCNSSLNP VIYTVFNQDF RRSFKHILFR RRRRGFRQ // ID DOP2_DROME STANDARD; PRT; 539 AA. AC Q24563; Q24569; Q9VAJ8; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Dopamine receptor 2. GN DOPR2 OR DOPR99B OR DAMB OR CG18741. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. (ISOFORM A), AND FUNCTION. RC STRAIN=Canton-S; TISSUE=Head; RX MEDLINE=96242088; PubMed=8656286; RA Feng G., Hannan F., Reale V., Hon Y.Y., Kousky C.T., Evans P.D., RA Hall L.M.; RT "Cloning and functional characterization of a novel dopamine receptor RT from Drosophila melanogaster."; RL J. Neurosci. 16:3925-3933(1996). RN [2] RP SEQUENCE FROM N.A. (ISOFORM B), FUNCTION, AND TISSUE SPECIFICITY. RC STRAIN=Canton-S; RX MEDLINE=96258265; PubMed=8663989; RA Han K.-A., Millar N.S., Grotewiel M.S., Davis R.L.; RT "DAMB, a novel dopamine receptor expressed specifically in Drosophila RT mushroom bodies."; RL Neuron 16:1127-1135(1996). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP REVISIONS, AND ALTERNATIVE SPLICING. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP SEQUENCE FROM N.A. (ISOFORM B). RC STRAIN=Berkeley; TISSUE=Head; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.E.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for dopamine. The activity of this receptor is CC mediated by G proteins which activate adenylyl cyclase. Also CC capable of generating a calcium signal. In terms of antagonist CC responses, would be classed with the D1-like dopamine receptor CC group. This receptor an attractive candidate for initiating CC biochemical cascades underlying olfactory learning. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=A; CC IsoId=Q24563-1; Sequence=Displayed; CC Name=B; CC IsoId=Q24563-2; Sequence=VSP_001877; CC Note=No experimental confirmation available; CC -!- TISSUE SPECIFICITY: Expressed in both central and peripheral CC nervous systems. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U34383; AAC47161.1; -. DR EMBL; U61264; AAB08000.1; -. DR EMBL; AE003770; AAF56908.2; -. DR EMBL; AE003770; AAN14180.1; -. DR EMBL; BT010212; AAQ23530.1; -. DR HSSP; P08913; 1HLL. DR FlyBase; FBgn0015129; DopR2. DR GO; GO:0004952; F:dopamine receptor activity; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00960; LMBPPROTEIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate; Alternative splicing. FT DOMAIN 1 113 Extracellular (Potential). FT TRANSMEM 114 134 1 (Potential). FT DOMAIN 135 145 Cytoplasmic (Potential). FT TRANSMEM 146 166 2 (Potential). FT DOMAIN 167 189 Extracellular (Potential). FT TRANSMEM 190 206 3 (Potential). FT DOMAIN 207 227 Cytoplasmic (Potential). FT TRANSMEM 228 248 4 (Potential). FT DOMAIN 249 266 Extracellular (Potential). FT TRANSMEM 267 287 5 (Potential). FT DOMAIN 288 420 Cytoplasmic (Potential). FT TRANSMEM 421 441 6 (Potential). FT DOMAIN 442 453 Extracellular (Potential). FT TRANSMEM 454 474 7 (Potential). FT DOMAIN 475 539 Cytoplasmic (Potential). FT DOMAIN 86 89 Poly-Gly. FT DOMAIN 338 351 Poly-Gly. FT DOMAIN 357 367 Poly-His. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT CARBOHYD 47 47 N-linked (GlcNAc...) (Potential). FT CARBOHYD 68 68 N-linked (GlcNAc...) (Potential). FT DISULFID 182 261 By similarity. FT LIPID 492 492 S-palmitoyl cysteine (Potential). FT LIPID 493 493 S-palmitoyl cysteine (Potential). FT VARSPLIC 511 539 RFATRRCYSTCSLHGIQHVRHNSCEQTYI -> CHVAAAMV FT AASTSFGYHSVNQIDRTLM (in isoform B). FT /FTId=VSP_001877. FT CONFLICT 496 496 K -> E (in Ref. 5). SQ SEQUENCE 539 AA; 59505 MW; 32FDDC0E935AF4B3 CRC64; MVDDNGSSPE VEGAEGAGAP LLALLRVDGL NQTQTRSPSP SFFGSYNISE DVYFYFNGLP TSTELVLNAT TSATSATLSP AMVATGGGGT TTPEPDLSEF LEALPNDRVG LLAFLFLFSF ATVFGNSLVI LAVIRERYLH TATNYFITSL AVADCLVGLV VMPFSALYEV LENTWFFGTD WCDIWRSLDV LFSTASILNL CVISLDRYWA ITDPFSYPMR MTVKRAAGLI AAVWICSSAI SFPAIVWWRA ARDGEMPAYK CTFTEHLGYL VFSSTISFYL PLLVMVFTYC RIYRAAVIQT RSLKIGTKQV LMASGELQLT LRIHRGGTTR DQQNQVSGGG GGGGGGGGGG GSLSHSHSHS HHHHHNHGGG TTTSTPEEPD DEPLSALHNN GLARHRHMGK NFSLSRKLAK FAKEKKAAKT LGIVMGVFII CWLPFFVVNL LSGFCIECIE HEEIVSAIVT WLGWINSCMN PVIYACWSRD FRRAFVRLLC MCCPRKIRRK YQPTMRSKSQ RFATRRCYST CSLHGIQHVR HNSCEQTYI // ID OAR2_LOCMI STANDARD; PRT; 484 AA. AC Q25322; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative tyramine receptor 2 (Tyr-Loc2). GN GCR2. OS Locusta migratoria (Migratory locust). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Orthopteroidea; Orthoptera; Caelifera; Acridomorpha; OC Acridoidea; Acrididae; Oedipodinae; Locusta. OX NCBI_TaxID=7004; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Neuron; RA Vanden Broeck J.J.M.; RL Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: G-PROTEIN COUPLED RECEPTOR FOR TYRAMINE, A KNOWN CC NEUROTRANSMITTER AND NEUROMODULATOR AND DIRECT PRECURSOR OF CC OCTOPAMINE (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X69521; CAA49269.1; -. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 54 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 55 77 1 (POTENTIAL). FT DOMAIN 78 87 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 88 109 2 (POTENTIAL). FT DOMAIN 110 126 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 127 147 3 (POTENTIAL). FT DOMAIN 148 167 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 168 190 4 (POTENTIAL). FT DOMAIN 191 215 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 216 237 5 (POTENTIAL). FT DOMAIN 238 411 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 412 433 6 (POTENTIAL). FT DOMAIN 434 448 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 449 470 7 (POTENTIAL). FT DOMAIN 471 484 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 13 13 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 198 198 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 124 203 BY SIMILARITY. FT DOMAIN 286 292 POLY-PRO. FT DOMAIN 294 307 ARG/LYS-RICH (BASIC). FT DOMAIN 348 360 POLY-THR. SQ SEQUENCE 484 AA; 53488 MW; 15C10608471D77CD CRC64; MVRVELQAAS LMNGSSAAEE PQDALVGGDA CGGRRPPSVL GVRLAVPEWE VAVTAVSLSL IILITIVGNV LVVLSVFTYK PLRIVQNFFI VSLAVADLTV AVLVMPFNVA YSLIQRWVFG IVVCKMWLTC DVLCCTASIL NLCAIALDRY WAITDPINYA QKRTLRRVLA MIAGVWLLSG VISSPPLIGW NDWPMEFNDT TPCQLTEEQG YVIYSSLGSF FIPLFIMTIV YVEIFIATKR RLRERAKASK LNSAMKQQMA AQAVPSSVPS HDQESVSSET NHNELPPPPA PPSKEKRRKT KKKSKKKDQA AEEGRFLAPA MVAEDSVTDN SVSVGPVAKN HLAEDGYTCT TTTTTTTTTT AVTDSPRSRT ASQKGSTAPP TPVQPKSIPV YQFIEEKQRI SLSKERRAAR TLGIIMGVFV VCWLPFFLMY VIVPFCNPSC KPSPKLVNFI TWLGYINSAL NPIIYTIFNL DFRRAFKKLL HFKT // ID A1AD_RAT STANDARD; PRT; 561 AA. AC P23944; DT 01-MAR-1992 (Rel. 21, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Alpha-1D adrenergic receptor (Alpha 1D-adrenoceptor) (Alpha 1D- DE adrenoreceptor) (Alpha-1A adrenergic receptor) (RA42). GN ADRA1D OR ADRA1A. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Brain cortex; RX MEDLINE=91177889; PubMed=1706716; RA Lomasney J.W., Cotecchia S., Lorenz W., Leung W.-Y., Schwinn D.A., RA Yang-Feng T.L., Brownstein M., Lefkowitz R.J., Caron M.G.; RT "Molecular cloning and expression of the cDNA for the alpha 1A- RT adrenergic receptor. The gene for which is located on human RT chromosome 5."; RL J. Biol. Chem. 266:6365-6369(1991). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=95114877; PubMed=7815325; RA Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., RA Worman N.P., Campbell S., Fidock M.D., Furness L.M., RA Parry-Smith D.J., Peter B., Bailey D.S.; RT "Cloning and pharmacological characterization of human alpha-1 RT adrenergic receptors: sequence corrections and direct comparison with RT other species homologues."; RL J. Pharmacol. Exp. Ther. 272:134-142(1995). CC -!- FUNCTION: This alpha-adrenergic receptor mediates its effect CC through the influx of extracellular calcium. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Vas deferens, hippocampus, cerebral cortex, CC aorta, brain stem, heart and spleen. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M60654; AAA63477.1; -. DR EMBL; L31771; AAB59704.1; -. DR PIR; A38731; A38731. DR RGD; 62064; Adra1d. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00240; ADRENRGCA1DR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 90 Extracellular (Potential). FT TRANSMEM 91 115 1 (Potential). FT DOMAIN 116 127 Cytoplasmic (Potential). FT TRANSMEM 128 153 2 (Potential). FT DOMAIN 154 163 Extracellular (Potential). FT TRANSMEM 164 186 3 (Potential). FT DOMAIN 187 207 Cytoplasmic (Potential). FT TRANSMEM 208 232 4 (Potential). FT DOMAIN 233 245 Extracellular (Potential). FT TRANSMEM 246 269 5 (Potential). FT DOMAIN 270 342 Cytoplasmic (Potential). FT TRANSMEM 343 367 6 (Potential). FT DOMAIN 368 374 Extracellular (Potential). FT TRANSMEM 375 399 7 (Potential). FT DOMAIN 400 561 Cytoplasmic (Potential). FT CARBOHYD 60 60 N-linked (GlcNAc...) (Potential). FT CARBOHYD 76 76 N-linked (GlcNAc...) (Potential). FT LIPID 413 413 S-palmitoyl cysteine (Potential). FT DOMAIN 21 57 Gly-rich. FT DOMAIN 416 421 Poly-Arg. FT CONFLICT 424 483 AVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGS FT ADTPETQDSVSSSRKPASA -> SLRPPLASLDRRRAFRLR FT PQPSHRSPRGPSSPHCTPGCGLGRHAGDAGFGLQQSKASLR FT (in Ref. 1). SQ SEQUENCE 561 AA; 59354 MW; B6537DCAD4F7BE27 CRC64; MTFRDILSVT FEGPRSSSST GGSGAGGGAG TVGPEGGAVG GVPGATGGGA VVGTGSGEDN QSSTGEPGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF ILTAVAGNLL VILSVACNRH LQTVTNYFIV NLAVADLLLS AAVLPFSATM EVLGFWAFGR TFCDVWAAVD VLCCTASILS LCTISVDRYV GVRHSLKYPA IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC GITEEVGYAI FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI HCRGAATSAK GYPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV FVLCWFPFFF VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS REFKRAFLRL LRCQCRRRRR RLWAVYGHHW RASTGDARSD CAPSPRIAPP GAPLALTAHP GAGSADTPET QDSVSSSRKP ASALREWRLL GPLQRPTTQL RAKVSSLSHK IRSGARRAET ACALRSEVEA VSLNVPQDGA EAVICQAYEP GDYSNLRETD I // ID 5H1B_SPAEH STANDARD; PRT; 386 AA. AC P56496; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 1B receptor (5-HT-1B) (Serotonin receptor 1B). GN HTR1B OR 5HT1B. OS Spalax leucodon ehrenbergi (Ehrenberg's mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Spalacinae; OC Nannospalax. OX NCBI_TaxID=30637; RN [1] RP SEQUENCE FROM N.A. RA Devor E.J., Nevo E.; RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Strongest to the other 5HT-1 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF027184; AAB82748.1; -. DR HSSP; P08913; 1HLL. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00513; 5HT1BRECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 47 Extracellular (Potential). FT TRANSMEM 48 71 1 (Potential). FT DOMAIN 72 82 Cytoplasmic (Potential). FT TRANSMEM 83 109 2 (Potential). FT DOMAIN 110 119 Extracellular (Potential). FT TRANSMEM 120 141 3 (Potential). FT DOMAIN 142 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 204 Extracellular (Potential). FT TRANSMEM 205 224 5 (Potential). FT DOMAIN 225 311 Cytoplasmic (Potential). FT TRANSMEM 312 332 6 (Potential). FT DOMAIN 333 346 Extracellular (Potential). FT TRANSMEM 347 369 7 (Potential). FT DOMAIN 370 386 Cytoplasmic (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT DISULFID 118 195 By similarity. FT LIPID 384 384 S-palmitoyl cysteine (Potential). SQ SEQUENCE 386 AA; 43101 MW; 7A006E021A44B7F4 CRC64; MEEPGARCAP PPPAGSQTQT PSSNLSHNCS ADSYIYQDSI ALPWKVLLVA LLALITLATT LSNAFVIATV YRTRKLHTPA NYLIASLAVT DLLVSILVMP ISTMYTVTGR WTLGQVVCDF WLSSDITCCT ASIMHLCVIA LDRYWAITDA VEYSAKRTPR RAAVMIALVW VFSISISLPR FFWRQAKAEE EVLDCLVNTD HVLYTVYSTV GAFYLPTLLL IALYGRIYVE ARSRILKQTP NKTGKRLSRA QLISDSPGST SSVTSINSRV PDVPSESGSP VYVNQVKVRV SDALLEKKKL MAARERKATK TLGIILGAFI VCWLPFFIIS LVMPICKDAC WFHMAIFDFF NWLGYLNSLI NPIIYTMPNE DFKQAFHKLI RFKCTG // ID 5H1B_CRIGR STANDARD; PRT; 386 AA. AC P46636; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE 5-hydroxytryptamine 1B receptor (5-HT-1B) (Serotonin receptor). GN HTR1B. OS Cricetulus griseus (Chinese hamster). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Cricetinae; OC Cricetulus. OX NCBI_TaxID=10029; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=DEDE; TISSUE=Lung; RA Wurch T., Palmier C., Colpaert F.C., Pauwels P.J.; RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Strongest to the other 5HT-1 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X86458; CAA60175.1; -. DR PIR; S54153; S54153. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 47 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 48 71 1 (POTENTIAL). FT DOMAIN 72 82 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 83 109 2 (POTENTIAL). FT DOMAIN 110 119 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 120 141 3 (POTENTIAL). FT DOMAIN 142 163 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 164 183 4 (POTENTIAL). FT DOMAIN 184 204 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 205 224 5 (POTENTIAL). FT DOMAIN 225 311 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 312 332 6 (POTENTIAL). FT DOMAIN 333 346 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 347 369 7 (POTENTIAL). FT DOMAIN 370 386 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 24 24 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 28 28 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 118 195 BY SIMILARITY. FT LIPID 384 384 S-palmitoyl cysteine (Potential). SQ SEQUENCE 386 AA; 42896 MW; B0DC6211C2B6DECE CRC64; MEEQGIQCAP PPPAASQTGV PLVNLSHNCS AESHIYQDSI ALPWKVLLVA LLALITLATT LSNAFVIATV YRTRKLHTPA NYLIASLAVT DLLVSILVMP VSTMYTVTGR WTLGQVVCDF WLSSDITCCT ASIMHLCVIA LDRYWAITDA VEYAAKRTPK RAAIMIALVW VFSISISLPP FFWRQAKAEE EVLTCLVNTD HVLYTVYSTG GAFYLPTLLL IALYGRIYVE ARSRILKQTP NKTGKRLTRA QLITDSPGST TSVTSINSRA PDLPSESGSP VYVNQVKVRV SDALLEKKKL MAARERKATK TLGIILGAFI VCWLPFFIIS LVMPICKDAC WFHMATLDFF NWLGYLNSLI NPIIYTMSNE DFKQAFHKLI RFKCAG // ID A1AA_CAVPO STANDARD; PRT; 466 AA. AC Q9WU25; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A- DE adrenoreceptor) (Alpha-1C adrenergic receptor). GN ADRA1A. OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Liver; RX MEDLINE=21419075; PubMed=11527538; RA Gonzalez-Espinosa C., Romero-Avila M.T., Mora-Rodriguez D.M., RA Gonzalez-Espinosa D., Garcia-Sainz J.A.; RT "Molecular cloning and functional expression of the guinea pig RT alpha(1a)-adrenoceptor."; RL Eur. J. Pharmacol. 426:147-155(2001). CC -!- FUNCTION: This alpha-adrenergic receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. Its effect is mediated by G(q) CC and G(11) proteins (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF108016; AAD22540.2; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00557; ADRENRGCA1AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 51 1 (Potential). FT DOMAIN 52 63 Cytoplasmic (Potential). FT TRANSMEM 64 89 2 (Potential). FT DOMAIN 90 99 Extracellular (Potential). FT TRANSMEM 100 122 3 (Potential). FT DOMAIN 123 143 Cytoplasmic (Potential). FT TRANSMEM 144 168 4 (Potential). FT DOMAIN 169 181 Extracellular (Potential). FT TRANSMEM 182 205 5 (Potential). FT DOMAIN 206 272 Cytoplasmic (Potential). FT TRANSMEM 273 297 6 (Potential). FT DOMAIN 298 304 Extracellular (Potential). FT TRANSMEM 305 329 7 (Potential). FT DOMAIN 330 466 Cytoplasmic (Potential). FT LIPID 345 345 S-palmitoyl cysteine (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 466 AA; 51577 MW; E0E27E4FF5D3D0CD CRC64; MVFLSGNASD SSNCTQPPAP VNIPKAILLG VILGVLILFG VPGNILVILS VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN IWAAVDVLCC TASIMSLCII SIDRYIGVSY PLRYPTIVTQ RRGLRALLCL WALSLVISIG PLFGWRQPAP QDETICQINE DPSYVLFSAL GSFYVPLAII LVMYCRVYVV AKRESRGLTS GLKTDKSDSE QVTLRIHRKN APLGGSGVAS SKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LKIQCLRRKQ SSKHALGYTL HPPSQAVEGQ HKDMVRIPVG SRETFYKISK TDGVCEWKFF SSMPRGSARI TVPKDQSACT TARVRSKSFL QVCCCVGPST PNPGENHQVP TIKIHTISLS ENGEEV // ID A2AB_RAT STANDARD; PRT; 453 AA. AC P19328; Q63021; Q925E4; DT 01-NOV-1990 (Rel. 16, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2B DE adrenoreceptor). GN ADRA2B. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Kidney; RX MEDLINE=90222177; PubMed=2158103; RA Zeng D., Harrison J.K., D'Angelo D.D., Barber C.M., Tucker A.L., RA Lu Z., Lynch K.R.; RT "Molecular characterization of a rat alpha 2B-adrenergic receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 87:3102-3106(1990). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RA Schaak S., Cussac D., Paris H.; RT "Cloning and characterization of the rat alpha2B-adrenergic receptor RT gene promoter."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE OF 6-453 FROM N.A. RC STRAIN=Sabra; TISSUE=Kidney; RX MEDLINE=95275492; PubMed=7755946; RA le Jossec M., Cloix J.F., Pecquery R., Giudicelli Y., Dausse J.P.; RT "Differential sodium regulation between salt-sensitive and salt- RT resistant Sabra rats is not due to any mutation in the renal alpha RT 2B-adrenoceptor gene."; RL Am. J. Hypertens. 8:177-182(1995). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M32061; AAA40635.1; -. DR EMBL; AF366899; AAK53388.1; -. DR EMBL; X74400; CAA52411.1; -. DR PIR; A35642; A35642. DR HSSP; P08913; 1HLL. DR RGD; 2057; Adra2b. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00559; ADRENRGCA2BR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Multigene family; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 17 Extracellular (Potential). FT TRANSMEM 18 42 1 (Potential). FT DOMAIN 43 54 Cytoplasmic (Potential). FT TRANSMEM 55 80 2 (Potential). FT DOMAIN 81 90 Extracellular (Potential). FT TRANSMEM 91 113 3 (Potential). FT DOMAIN 114 135 Cytoplasmic (Potential). FT TRANSMEM 136 158 4 (Potential). FT DOMAIN 159 174 Extracellular (Potential). FT TRANSMEM 175 198 5 (Potential). FT DOMAIN 199 375 Cytoplasmic (Potential). FT TRANSMEM 376 399 6 (Potential). FT DOMAIN 400 408 Extracellular (Potential). FT TRANSMEM 409 432 7 (Potential). FT DOMAIN 433 453 Cytoplasmic (Potential). FT DISULFID 90 169 By similarity. FT LIPID 445 445 S-palmitoyl cysteine (Potential). FT DOMAIN 300 314 Asp/Glu-rich (acidic). FT SITE 97 97 IMPLICATED IN LIGAND BINDING (BY FT SIMILARITY). FT SITE 181 181 Implicated in catechol agonist binding FT (By similarity). FT SITE 185 185 Implicated in catechol agonist binding FT (By similarity). FT CONFLICT 132 132 R -> C (in Ref. 1). FT CONFLICT 162 163 EP -> DA (in Ref. 1). SQ SEQUENCE 453 AA; 50369 MW; CBA69CE23EACB511 CRC64; MSGPTMDHQE PYSVQATAAI ASAITFLILF TIFGNALVIL AVLTSRSLRA PQNLFLVSLA AADILVATLI IPFSLANELL GYWYFWRAWC EVYLALDVLF CTSSIVHLCA ISLDRYWAVS RALEYNSKRT PRRIKCIILT VWLIAAVISL PPLIYKGDQR PEPRGLPQCE LNQEAWYILA SSIGSFFAPC LIMILVYLRI YVIAKRSHCR GLGAKRGSGE GESKKPQPVA GGVPTSAKVP TLVSPLSSVG EANGHPKPPR EKEEGETPED PEARALPPTW SALPRSGQGQ KKGTSGATAE EGDEEDEEEV EECEPQTLPA SPASVCNPPL QQPQTSRVLA TLRGQVLLGK NVGVASGQWW RRRTQLSREK RFTFVLAVVI GVFVVCWFPF FFSYSLGAIC PQHCKVPHGL FQFFFWIGYC NSSLNPVIYT VFNQDFRRAF RRILCRPWTQ TGW // ID ACM4_CHICK STANDARD; PRT; 490 AA. AC P17200; DT 01-AUG-1990 (Rel. 15, Created) DT 01-AUG-1990 (Rel. 15, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Muscarinic acetylcholine receptor M4. GN CHRM4. OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90153912; PubMed=2154460; RA Tietje K.M., Goldman P.S., Nathanson N.M.; RT "Cloning and functional analysis of a gene encoding a novel RT muscarinic acetylcholine receptor expressed in chick heart and RT brain."; RL J. Biol. Chem. 265:2828-2834(1990). CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is inhibition of adenylate cyclase. May couple to multiple CC functional responses in cell lines. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in heart and brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; J05218; AAA48563.1; -. DR PIR; A35546; A35546. DR HSSP; P02699; 1BOJ. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PRINTS; PR00541; MUSCRINICM4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Postsynaptic membrane; Glycoprotein; Transmembrane; Phosphorylation; KW Multigene family; G-protein coupled receptor. FT DOMAIN 1 42 Extracellular (Potential). FT TRANSMEM 43 64 1 (Potential). FT DOMAIN 65 78 Cytoplasmic (Potential). FT TRANSMEM 79 99 2 (Potential). FT DOMAIN 100 116 Extracellular (Potential). FT TRANSMEM 117 138 3 (Potential). FT DOMAIN 139 158 Cytoplasmic (Potential). FT TRANSMEM 159 181 4 (Potential). FT DOMAIN 182 203 Extracellular (Potential). FT TRANSMEM 204 226 5 (Potential). FT DOMAIN 227 412 Cytoplasmic (Potential). FT TRANSMEM 413 433 6 (Potential). FT DOMAIN 434 447 Extracellular (Potential). FT TRANSMEM 448 467 7 (Potential). FT DOMAIN 468 490 Cytoplasmic (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 25 25 N-linked (GlcNAc...) (Potential). FT DISULFID 115 195 By similarity. SQ SEQUENCE 490 AA; 54937 MW; 2CDFDB5FA7D2298E CRC64; MHNLSAQPWQ AKMANLTYDN VTLSNRSEVA IQPPTNYKTV ELVFIATVTG SLSLVTVVGN ILVMLSIKVN RQLQTVNNYF LFSLACADLI IGVFSMNLYT VYIIKGYWPL GAVVCDLWLA LDYVVSNASV MNLLIISFDR YFCVTKPLTY PARRTTKMAG LMIAAAWILS FILWAPAILF WQFIVGKRTV HERECYIQFL SNPAVTFGTA IAAFYLPVVI MTVLYIHISL ASRSRVRRHK PESRKERKGK SLSFFKAPPV KQNNNNSPKR AVEVKEEVRN GKVDDQPSAQ TEATGQQEEK ETSNESSTVS MTQTTKDKPT TEILPAGQGQ SPAHPRVNPT SKWSKIKIVT KQTGTESVTA IEIVPAKAGA SDHNSLSNSR PANVARKFAS IARSQVRKKR QMAAREKKVT RTIFAILLAF ILTWTPYNVM VLINTFCETC VPETVWSIGY WLCYVNSTIN PACYALCNAT FKKTFKHLLM CQYRNIGTAR // ID A1AB_MESAU STANDARD; PRT; 515 AA. AC P18841; DT 01-NOV-1990 (Rel. 16, Created) DT 01-NOV-1990 (Rel. 16, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Alpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B- DE adrenoreceptor). GN ADRA1B. OS Mesocricetus auratus (Golden hamster). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Cricetinae; OC Mesocricetus. OX NCBI_TaxID=10036; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=89017157; PubMed=2845398; RA Cotecchia S., Schwinn D.A., Randall R.R., Lefkowitz R.J., RA Caron M.G., Kobilka B.K.; RT "Molecular cloning and expression of the cDNA for the hamster alpha RT 1-adrenergic receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 85:7159-7163(1988). RN [2] RP MUTAGENESIS OF ALA-293. RX MEDLINE=92112850; PubMed=1346134; RA Kjelsberg M.A., Cotecchia S., Ostrowski J., Caron M.G., RA Lefkowitz R.J.; RT "Constitutive activation of the alpha 1B-adrenergic receptor by all RT amino acid substitutions at a single site. Evidence for a region RT which constrains receptor activation."; RL J. Biol. Chem. 267:1430-1433(1992). CC -!- FUNCTION: This alpha-adrenergic receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; J04084; AAA58964.1; -. DR PIR; A40491; A40491. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00556; ADRENRGCA1BR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 45 Extracellular (Potential). FT TRANSMEM 46 70 1 (Potential). FT DOMAIN 71 83 Cytoplasmic (Potential). FT TRANSMEM 84 105 2 (Potential). FT DOMAIN 106 115 Extracellular (Potential). FT TRANSMEM 116 141 3 (Potential). FT DOMAIN 142 161 Cytoplasmic (Potential). FT TRANSMEM 162 182 4 (Potential). FT DOMAIN 183 201 Extracellular (Potential). FT TRANSMEM 202 224 5 (Potential). FT DOMAIN 225 295 Cytoplasmic (Potential). FT TRANSMEM 296 319 6 (Potential). FT DOMAIN 320 326 Extracellular (Potential). FT TRANSMEM 327 340 7 (Potential). FT DOMAIN 341 515 Cytoplasmic (Potential). FT DOMAIN 371 378 Poly-Arg. FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential). FT DISULFID 118 195 By similarity. FT LIPID 365 365 S-palmitoyl cysteine (Potential). FT MUTAGEN 293 293 A->X: Confers constitutive activity. SQ SEQUENCE 515 AA; 56492 MW; 6DAF1576D1C1CE2D CRC64; MNPDLDTGHN TSAPAQWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGL VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFM RILGCQCRSG RRRRRRRRLG ACAYTYRPWT RGGSLERSQS RKDSLDDSGS CMSGSQRTLP SASPSPGYLG RGAQPPLELC AYPEWKSGAL LSLPEPPGRR GRLDSGPLFT FKLLGEPESP GTEGDASNGG CDATTDLANG QPGFKSNMPL APGHF // ID ACM2_HUMAN STANDARD; PRT; 466 AA. AC P08172; Q9P1X9; DT 01-AUG-1988 (Rel. 08, Created) DT 01-AUG-1988 (Rel. 08, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Muscarinic acetylcholine receptor M2. GN CHRM2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=87263421; PubMed=3037705; RA Bonner T.I., Buckley N.J., Young A.C., Brann M.R.; RT "Identification of a family of muscarinic acetylcholine receptor RT genes."; RL Science 237:527-532(1987). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=88166632; PubMed=3443095; RA Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., RA Ramachandran J., Capon D.J.; RT "Distinct primary structures, ligand-binding properties and tissue- RT specific expression of four human muscarinic acetylcholine RT receptors."; RL EMBO J. 6:3923-3929(1987). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE OF 27-466 FROM N.A. RA Kitano T., Kobayakawa H., Saitou N.; RT "Silver project."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is adenylate cyclase inhibition. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M16404; AAA51570.1; -. DR EMBL; X15264; CAA33335.1; -. DR EMBL; AF498916; AAM18939.1; -. DR EMBL; AB041391; BAA94476.1; -. DR PIR; S10126; S10126. DR PDB; 1LUB; 19-JUN-02. DR Genew; HGNC:1951; CHRM2. DR MIM; 118493; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004981; F:muscarinic acetylcholine receptor activity; TAS. DR GO; GO:0007188; P:G-protein signaling, coupled to cAMP nucleo...; TAS. DR GO; GO:0007207; P:muscarinic acetyl choline receptor, phospho...; TAS. DR GO; GO:0007399; P:neurogenesis; TAS. DR GO; GO:0008016; P:regulation of heart rate; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PRINTS; PR00539; MUSCRINICM2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Postsynaptic membrane; Glycoprotein; Transmembrane; Phosphorylation; KW Multigene family; G-protein coupled receptor; Receptor; 3D-structure. FT DOMAIN 1 22 Extracellular (Potential). FT TRANSMEM 23 45 1 (Potential). FT DOMAIN 46 59 Cytoplasmic (Potential). FT TRANSMEM 60 80 2 (Potential). FT DOMAIN 81 97 Extracellular (Potential). FT TRANSMEM 98 119 3 (Potential). FT DOMAIN 120 139 Cytoplasmic (Potential). FT TRANSMEM 140 162 4 (Potential). FT DOMAIN 163 184 Extracellular (Potential). FT TRANSMEM 185 207 5 (Potential). FT DOMAIN 208 388 Cytoplasmic (Potential). FT TRANSMEM 389 409 6 (Potential). FT DOMAIN 410 423 Extracellular (Potential). FT TRANSMEM 424 443 7 (Potential). FT DOMAIN 444 466 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT DISULFID 96 176 By similarity. FT MOD_RES 446 446 Phosphothreonine (Potential). FT MOD_RES 450 450 Phosphothreonine (Potential). FT MOD_RES 465 465 Phosphothreonine (Potential). SQ SEQUENCE 466 AA; 51715 MW; 2FC2FD7748C22BEC CRC64; MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI VKPNNNNMPS SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR // ID HH3R_RAT STANDARD; PRT; 445 AA. AC Q9QYN8; Q9QYN6; Q9QYN7; Q9QYN9; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Histamine H3 receptor (HH3R). GN HRH3. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. (ISOFORM 1). RC TISSUE=Hypothalamus; RX MEDLINE=20330707; PubMed=10869375; RA Lovenberg T.W., Pyati J., Chang H., Wilson S.J., Erlander M.G.; RT "Cloning of rat histamine H3 receptor reveals distinct species RT pharmacological profiles."; RL J. Pharmacol. Exp. Ther. 293:771-778(2000). RN [2] RP SEQUENCE FROM N.A. (ISOFORMS 1 AND 2). RC TISSUE=Striatum; RX MEDLINE=21016732; PubMed=11130725; RA Morisset S., Rouleau A., Ligneau X., Gbahou F., Tardivel-Lacombe J., RA Stark H., Schunack W., Ganellin C.R., Schwartz J.-C., Arrang J.-M.; RT "High constitutive activity of native H3 receptors regulates histamine RT neurons in brain."; RL Nature 408:860-864(2000). RN [3] RP SEQUENCE FROM N.A. (ISOFORMS 1; 2; 3 AND 4). RA Itadani H., Takimura T., Nakamura T., Ohta M.; RT "Cloning of a novel G protein-coupled receptor."; RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases. RN [4] RP TISSUE SPECIFICITY. RX MEDLINE=99278519; PubMed=10347254; RA Lovenberg T.W., Roland B.L., Wilson S.J., Jiang X., Pyati J., RA Huvar A., Jackson M.R., Erlander M.G.; RT "Cloning and functional expression of the human histamine H3 RT receptor."; RL Mol. Pharmacol. 55:1101-1107(1999). CC -!- FUNCTION: THE H3 SUBCLASS OF HISTAMINE RECEPTORS COULD MEDIATE THE CC HISTAMINE SIGNALS IN CNS AND PERIPHERAL NERVOUS SYSTEM. SIGNALS CC THROUGH THE INHIBITION OF ADENYLATE CYCLASE AND DISPLAYS HIGH CC CONSTITUTIVE ACTIVITY (SPONTANEOUS ACTIVITY IN THE ABSENCE OF CC AGONIST). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Comment=Additional isoforms seem to exist; CC Name=1; Synonyms=H3L; CC IsoId=Q9QYN8-1; Sequence=Displayed; CC Name=2; Synonyms=H3S; CC IsoId=Q9QYN8-2; Sequence=VSP_001887; CC Name=3; CC IsoId=Q9QYN8-3; Sequence=VSP_001888; CC Name=4; CC IsoId=Q9QYN8-4; Sequence=VSP_001888, VSP_001889; CC -!- TISSUE SPECIFICITY: EXPRESSED ABUNDANTLY IN BRAIN, MOST NOTABLY CC THROUGHOUT THE THALAMUS, THE VENTROMEDIAL HYPOTHALAMUS AND THE CC CAUDATE NUCLEUS. ISOFORM 1 IS LARGELY PREDOMINANT IN ALL TISSUES. CC -!- MISCELLANEOUS: Proxyfan acts as a potent neutral antagonist while CC thioperamide, ciproxifan and FUB465 act as potent inverse CC agonists. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF237919; AAF82086.1; -. DR EMBL; AY009370; AAK02069.1; -. DR EMBL; AB015646; BAA88765.1; -. DR EMBL; AB015646; BAA88766.1; -. DR EMBL; AB015646; BAA88767.1; -. DR EMBL; AB015646; BAA88768.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003980; H3_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01471; HISTAMINEH3R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Alternative splicing. FT DOMAIN 1 39 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 40 60 POTENTIAL. FT DOMAIN 61 70 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 71 91 POTENTIAL. FT DOMAIN 92 108 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 109 129 POTENTIAL. FT DOMAIN 130 156 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 157 177 POTENTIAL. FT DOMAIN 178 196 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 197 217 POTENTIAL. FT DOMAIN 218 359 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 360 380 POTENTIAL. FT DOMAIN 381 396 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 397 417 POTENTIAL. FT DOMAIN 418 445 CYTOPLASMIC (POTENTIAL). FT DOMAIN 20 23 POLY-ALA. FT CARBOHYD 11 11 N-LINKED (GLCNAC...) (POTENTIAL). FT VARSPLIC 274 305 Missing (in isoform 2). FT /FTId=VSP_001887. FT VARSPLIC 274 321 Missing (in isoform 3 and isoform 4). FT /FTId=VSP_001888. FT VARSPLIC 393 445 WYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLK FT VQPHGSLEQCWK -> CVERLGKLEASLLLPLWMFSGRWRR FT RKHVCELDVPWMFNQERQNCRGARGWIGRCGLPRPPPSVLQ FT LPAEPRQLLLPAPPPGLGRWPCPACPVCTIRIWGWVVMG FT (in isoform 4). FT /FTId=VSP_001889. SQ SEQUENCE 445 AA; 48588 MW; 63DFEFC21758FE5B CRC64; MERAPPDGLM NASGTLAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW TFGRGLCKLW LVVDYLLCAS SVFNIVLISY DRFLSVTRAV SYRAQQGDTR RAVRKMALVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGGREAG PEPPPDAQPS PPPAPPSCWG CWPKGHGEAM PLHRYGVGEA GPGVEAGEAA LGGGSGGGAA ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL SRDKKVAKSL AIIVSIFGLC WAPYTLLMII RAACHGRCIP DYWYETSFWL LWANSAVNPV LYPLCHYSFR RAFTKLLCPQ KLKVQPHGSL EQCWK // ID DADR_PIG STANDARD; PRT; 446 AA. AC P50130; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE D(1A) dopamine receptor. GN DRD1. OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95208810; PubMed=7900842; RA Grenader A.C., O'Rourke D.A., Healy D.P.; RT "Cloning of the porcine D1A dopamine receptor gene expressed in renal RT epithelial LLC-PK1 cells."; RL Am. J. Physiol. 268:F423-F434(1995). CC -!- FUNCTION: THIS IS ONE OF THE FIVE TYPES (D1 TO D5) OF RECEPTORS CC FOR DOPAMINE. THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G CC PROTEINS WHICH ACTIVATE ADENYLYL CYCLASE. CC -!- SUBUNIT: Interacts with calcyon (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U25681; AAA79848.1; -. DR PIR; I47217; I47217. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 23 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 24 49 1 (POTENTIAL). FT DOMAIN 50 60 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 61 87 2 (POTENTIAL). FT DOMAIN 88 96 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 97 119 3 (POTENTIAL). FT DOMAIN 120 138 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 139 163 4 (POTENTIAL). FT DOMAIN 164 192 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 193 218 5 (POTENTIAL). FT DOMAIN 219 272 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 273 299 6 (POTENTIAL). FT DOMAIN 300 312 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 313 337 7 (POTENTIAL). FT DOMAIN 338 446 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 96 186 BY SIMILARITY. FT LIPID 347 347 S-palmitoyl cysteine (By similarity). FT LIPID 351 351 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 446 AA; 49257 MW; A56BFA0D93D50DBB CRC64; MRTLNTSTMD GTGLVVERDF SFRILTACFL SLLILSTLLG NTLVCAAVIR FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL SVLISFIPVQ LSWHKAKPTS PSDGNVTSLG KTTHNCDSSL SRTYAISSSL ISFYIPVAIM IVTYTRIYRI AQKQIRRISA LERAAVHAKN CQTTAGNGNP AECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCMVPFCGS GETKPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL CPTSTNAIET VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED LKKEEAGGIA SPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT // ID DADR_XENLA STANDARD; PRT; 451 AA. AC P42289; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE D(1A) dopamine receptor. OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus. OX NCBI_TaxID=8355; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95024150; PubMed=7937989; RA Sugamori K.S., Demchyshyn L.L., Chung M., Niznik H.B.; RT "D1A, D1B, and D1C dopamine receptors from Xenopus laevis."; RL Proc. Natl. Acad. Sci. U.S.A. 91:10536-10540(1994). CC -!- FUNCTION: THIS IS ONE OF THE FIVE TYPES (D1 TO D5) OF RECEPTORS CC FOR DOPAMINE. THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G CC PROTEINS WHICH ACTIVATE ADENYLYL CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U07863; AAA50828.1; -. DR PIR; I51659; I51659. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 22 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 23 48 1 (POTENTIAL). FT DOMAIN 49 59 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 60 86 2 (POTENTIAL). FT DOMAIN 87 95 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 96 118 3 (POTENTIAL). FT DOMAIN 119 137 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 138 162 4 (POTENTIAL). FT DOMAIN 163 191 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 192 217 5 (POTENTIAL). FT DOMAIN 218 271 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 272 298 6 (POTENTIAL). FT DOMAIN 299 315 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 316 340 7 (POTENTIAL). FT DOMAIN 341 451 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 95 185 BY SIMILARITY. FT LIPID 350 350 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 451 AA; 50549 MW; 3A0F8AB36C166687 CRC64; MTFNITSMDE DVLLTERESS FRVLTGCFLS VLILSTLLGN TLVCAAVIRF RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP FGTFCNIWVA FDIMCSTASI LNLCVISVDR YWAISSPFRY ERKMTPKVAF IMIGVAWTLS VLISFIPVQL NWHKAKTTSF FDLNITLHDR TMDNCDSSLN RTYAISSSLI SFYIPVAIMI VTYTRIYRIA AKQIRRISAL ERAAVHAKNC QNSTSNRNSL DCQQPESSLK TSFKRETKVL KTLSVIMGVF VCCWLPFFIL NCIVPFCDPS LTTSGTEPFC ISSTTFDVFV WFGWANSSLN PIIYAFNADF RKAFSNLLGC YRLCPTSNNI IETVSINNNG AVVYSCQQEP KGSIPNECNL VYLIPHAIIC PEDEVLKKED ESGLSKSLEK MSPAFSGILD YDADVSLEKI NPITQNGQPK T // ID B3AR_MOUSE STANDARD; PRT; 400 AA. AC P25962; Q9QZ98; DT 01-MAY-1992 (Rel. 22, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Beta-3 adrenergic receptor (Beta-3 adrenoceptor) (Beta-3 DE adrenoreceptor). GN ADRB3 OR ADRB3R OR B3BAR. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Swiss; RX MEDLINE=92037534; PubMed=1718744; RA Nahmias C., Blin N., Elalouf J.M., Mattei M.-G., Strosberg A.D., RA Emorine L.J.; RT "Molecular characterization of the mouse beta 3-adrenergic receptor: RT relationship with the atypical receptor of adipocytes."; RL EMBO J. 10:3721-3727(1991). RN [2] RP REVISIONS, SEQUENCE FROM N.A. RX MEDLINE=93279311; PubMed=8389293; RA van Spronsen A., Nahmias C., Krief S., Briend-Sutren M.-M., RA Strosberg A.D., Emorine L.J.; RT "The promoter and intron/exon structure of the human and mouse beta RT 3-adrenergic-receptor genes."; RL Eur. J. Biochem. 213:1117-1124(1993). RN [3] RP SEQUENCE FROM N.A. (ISOFORM B). RC STRAIN=C57BL/6; TISSUE=Brown adipose tissue; RX MEDLINE=99396494; PubMed=10455305; RA Evans B.A., Papaioannou M., Hamilton S., Summers R.J.; RT "Alternative splicing generates two isoforms of the beta3-adrenoceptor RT which are differentially expressed in mouse tissues."; RL Br. J. Pharmacol. 127:1525-1531(1999). RN [4] RP SEQUENCE OF 378-400 FROM N.A. RC TISSUE=Adipose tissue; RX MEDLINE=93125503; PubMed=1336117; RA Granneman J.G., Lahners K.N., Rao D.D.; RT "Rodent and human beta 3-adrenergic receptor genes contain an intron RT within the protein-coding block."; RL Mol. Pharmacol. 42:964-970(1992). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. Beta-3 is involved in the regulation of lipolysis and CC thermogenesis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=A; CC IsoId=P25962-1; Sequence=Displayed; CC Name=B; CC IsoId=P25962-2; Sequence=VSP_001864; CC -!- TISSUE SPECIFICITY: White and brown adipose tissues, and digestive CC tract. Isoform B highest in brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X72862; CAA51384.1; -. DR EMBL; X60438; CAA42966.1; -. DR EMBL; AF193027; AAF05768.1; -. DR EMBL; S53290; AAB24836.1; -. DR PIR; S32804; S32804. DR MGD; MGI:87939; Adrb3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00563; ADRENRGCB3AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate; KW Alternative splicing. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 60 1 (Potential). FT DOMAIN 61 69 Cytoplasmic (Potential). FT TRANSMEM 70 88 2 (Potential). FT DOMAIN 89 108 Extracellular (Potential). FT TRANSMEM 109 130 3 (Potential). FT DOMAIN 131 152 Cytoplasmic (Potential). FT TRANSMEM 153 175 4 (Potential). FT DOMAIN 176 200 Extracellular (Potential). FT TRANSMEM 201 222 5 (Potential). FT DOMAIN 223 289 Cytoplasmic (Potential). FT TRANSMEM 290 311 6 (Potential). FT DOMAIN 312 323 Extracellular (Potential). FT TRANSMEM 324 344 7 (Potential). FT DOMAIN 345 400 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT DISULFID 107 186 By similarity. FT LIPID 358 358 S-palmitoyl cysteine (By similarity). FT VARSPLIC 388 400 RFDGYEGARPFPT -> SSLLREPRHLYTCLGYP (in FT isoform B). FT /FTId=VSP_001864. SQ SEQUENCE 400 AA; 43006 MW; 374E072C01DFA32E CRC64; MAPWPHRNGS LALWSDAPTL DPSAANTSGL PGVPWAAALA GALLALATVG GNLLVIIAIA RTPRLQTITN VFVTSLAAAD LVVGLLVMPP GATLALTGHW PLGETGCELW TSVDVLCVTA SIETLCALAV DRYLAVTNPL RYGTLVTKRR ARAAVVLVWI VSAAVSFAPI MSQWWRVGAD AEAQECHSNP RCCSFASNMP YALLSSSVSF YLPLLVMLFV YARVFVVAKR QRHLLRRELG RFSPEESPPS PSRSPSPATG GTPAAPDGVP PCGRRPARLL PLREHRALRT LGLIMGIFSL CWLPFFLANV LRALAGPSLV PSGVFIALNW LGYANSAFNP VIYCRSPDFR DAFRRLLCSY GGRGPEEPRA VTFPASPVEA RQSPPLNRFD GYEGARPFPT // ID D3DR_CERAE STANDARD; PRT; 400 AA. AC P52703; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE D(3) dopamine receptor. GN DRD3. OS Cercopithecus aethiops (Green monkey) (Grivet). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Cercopithecus. OX NCBI_TaxID=9534; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Ross P.C.; RL Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: THIS IS ONE OF THE FIVE TYPES (D1 TO D5) OF RECEPTORS CC FOR DOPAMINE. THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G CC PROTEINS WHICH INHIBIT ADENYLYL CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U21307; AAA75379.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 32 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 33 55 1 (POTENTIAL). FT DOMAIN 56 66 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 67 92 2 (POTENTIAL). FT DOMAIN 93 104 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 105 126 3 (POTENTIAL). FT DOMAIN 127 149 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 150 172 4 (POTENTIAL). FT DOMAIN 173 185 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 186 209 5 (POTENTIAL). FT DOMAIN 210 329 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 330 351 6 (POTENTIAL). FT DOMAIN 352 366 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 367 388 7 (POTENTIAL). FT DOMAIN 389 400 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 12 12 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 19 19 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 97 97 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 173 173 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 103 181 BY SIMILARITY. SQ SEQUENCE 400 AA; 44336 MW; 9358843CB0BA698B CRC64; MAPLSQLSGH LNYTCGVENS TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR VCCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV TLMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDRAHL ELKRYYSICQ DTALGGPGFQ ERGGELKREE RTRNSLSPTI APKLSLEVRK LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC // ID DADR_MOUSE STANDARD; PRT; 446 AA. AC Q61616; Q8C8P8; DT 01-NOV-1997 (Rel. 35, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE D(1A) dopamine receptor. GN DRD1 OR DRD1A OR GPCR15. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6J; TISSUE=Retina; RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [2] RP SEQUENCE OF 193-279 FROM N.A. RC TISSUE=Testis; RX MEDLINE=94116980; PubMed=8288218; RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., RA Copeland N.G., Jenkins N.A.; RT "Identification, chromosomal location, and genome organization of RT mammalian G-protein-coupled receptors."; RL Genomics 18:175-184(1993). CC -!- FUNCTION: THIS IS ONE OF THE FIVE TYPES (D1 TO D5) OF RECEPTORS CC FOR DOPAMINE. THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G CC PROTEINS WHICH ACTIVATE ADENYLYL CYCLASE. CC -!- SUBUNIT: Interacts with calcyon (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AK044723; BAC32050.1; -. DR EMBL; L20336; AAA16848.1; -. DR MGD; MGI:99578; Drd1a. DR GO; GO:0005624; C:membrane fraction; IDA. DR GO; GO:0001590; F:dopamine D1 receptor activity; IDA. DR GO; GO:0007191; P:dopamine receptor, adenylate cyclase activa...; IDA. DR GO; GO:0007626; P:locomotory behavior; IMP. DR GO; GO:0042493; P:response to drug; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 22 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 23 48 1 (POTENTIAL). FT DOMAIN 49 59 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 60 86 2 (POTENTIAL). FT DOMAIN 87 95 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 96 118 3 (POTENTIAL). FT DOMAIN 119 137 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 138 162 4 (POTENTIAL). FT DOMAIN 163 192 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 193 218 5 (POTENTIAL). FT DOMAIN 219 272 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 273 299 6 (POTENTIAL). FT DOMAIN 300 312 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 313 337 7 (POTENTIAL). FT DOMAIN 338 446 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 95 186 BY SIMILARITY. FT LIPID 347 347 S-palmitoyl cysteine (By similarity). FT LIPID 351 351 S-palmitoyl cysteine (By similarity). FT CONFLICT 193 196 TYAI -> DIRH (IN REF. 2). FT CONFLICT 240 240 N -> S (IN REF. 2). SQ SEQUENCE 446 AA; 49612 MW; 509BA66F9DF82A74 CRC64; MAPNTSTMDE TGLPVERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP FGSFCNIWVA FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS VLISFIPVQL SWHKAKPTWP LDGNFTSLED AEDDNCDTRL SRTYAISSSL ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTTGNGNP VECSQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL CPTTNNAIET VSINNNGAVM FSSHHEPRGS ISKDCNLVYL IPHAVGSSED LKREEAGGIP KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST // ID B2AR_RAT STANDARD; PRT; 418 AA. AC P10608; DT 01-JUL-1989 (Rel. 11, Created) DT 01-JUL-1989 (Rel. 11, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2 DE adrenoreceptor). GN ADRB2 OR ADRB2R. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=88068581; PubMed=2825184; RA Gocayne J.D., Robinson D.A., Fitzgerald M.G., Chung F.-Z., RA Kerlavage A.R., Lentes K.-U., Lai J., Wang C.-D., Fraser C.M., RA Venter J.C.; RT "Primary structure of rat cardiac beta-adrenergic and muscarinic RT cholinergic receptors obtained by automated DNA sequence analysis: RT further evidence for a multigene family."; RL Proc. Natl. Acad. Sci. U.S.A. 84:8296-8300(1987). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Liver; RX MEDLINE=90175020; PubMed=2155412; RA Buckland P.R., Hill R.M., Tidmarsh S.F., McGuffin P.; RT "Primary structure of the rat beta-2 adrenergic receptor gene."; RL Nucleic Acids Res. 18:682-682(1990). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=96011661; PubMed=7590294; RA Jiang L., Kunos G.; RT "Sequence of the 5' regulatory domain of the gene encoding the rat RT beta 2-adrenergic receptor."; RL Gene 163:331-332(1995). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. The beta-2-adrenergic receptor binds epinephrine with an CC approximately 30-fold greater affinity than it does CC norepinephrine. CC -!- SUBUNIT: Binds SLC9A3R1 (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Palmitoylated; may reduce accessibility of Ser-345 and Ser- CC 346 by anchoring Cys-341 to the plasma membrane. Agonist CC stimulation promotes depalmitoylation and further allows Ser-345 CC and Ser-346 phosphorylation (By similarity). CC -!- PTM: Phosphorylated by PKA and BARK; mediate homologous CC desensitization of the receptor. PKA-mediated phosphorylation CC seems to facilitate phosphorylation by BARK (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; J03024; AAA40675.1; -. DR EMBL; X17607; CAA35609.1; -. DR EMBL; L39264; AAA89068.1; -. DR PIR; S10855; S10855. DR RGD; 2060; Adrb2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00562; ADRENRGCB2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 34 Extracellular (Potential). FT TRANSMEM 35 58 1 (Potential). FT DOMAIN 59 71 Cytoplasmic (Potential). FT TRANSMEM 72 95 2 (Potential). FT DOMAIN 96 106 Extracellular (Potential). FT TRANSMEM 107 129 3 (Potential). FT DOMAIN 130 150 Cytoplasmic (Potential). FT TRANSMEM 151 174 4 (Potential). FT DOMAIN 175 196 Extracellular (Potential). FT TRANSMEM 197 220 5 (Potential). FT DOMAIN 221 274 Cytoplasmic (Potential). FT TRANSMEM 275 298 6 (Potential). FT DOMAIN 299 305 Extracellular (Potential). FT TRANSMEM 306 329 7 (Potential). FT DOMAIN 330 418 Cytoplasmic (Potential). FT SITE 113 113 IMPLICATED IN CATECHOL AGONIST AND FT ANTAGONIST BINDING (BY SIMILARITY). FT SITE 204 204 Implicated in catechol agonist binding FT (By similarity). FT SITE 207 207 Implicated in catechol agonist binding FT (By similarity). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Probable). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Probable). FT DISULFID 106 184 By similarity. FT LIPID 341 341 S-palmitoyl cysteine (By similarity). FT MOD_RES 261 261 Phosphoserine (by PKA) (Potential). FT MOD_RES 262 262 Phosphoserine (by PKA) (Potential). FT MOD_RES 345 345 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 346 346 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 355 355 Phosphoserine (by BARK) (Probable). FT MOD_RES 356 356 Phosphoserine (by BARK) (Probable). FT CONFLICT 262 262 S -> F (in Ref. 2). FT CONFLICT 334 334 I -> Y (in Ref. 2). SQ SEQUENCE 418 AA; 46891 MW; 907B2882AFC02AC5 CRC64; MEPHGNDSDF LLAPNGSRAP GHDITQERDE AWVVGMAILM SVIVLAIVFG NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG ASHILMKMWN FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYVAITSPFK YQSLLTKNKA RVVILMVWIV SGLTSFLPIQ MHWYRATHKQ AIDCYAKETC CDFFTNQAYA IASSIVSFYV PLVVMVFVYS RVFQVAKRQL QKIDKSEGRF HAQNLSQVEQ DGRSGHGLRS SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIRA NLIPKEVYIL LNWLGYVNSA FNPLIYCRSP DFRIAFQELL CLRRSSSKTY GNGYSSNSNG RTDYTGEQSA YQLGQEKENE LLCEEAPGME GFVNCQGTVP SLSIDSQGRN CNTNDSPL // ID DCDR_XENLA STANDARD; PRT; 465 AA. AC P42291; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE D(1C) dopamine receptor. OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus. OX NCBI_TaxID=8355; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95024150; PubMed=7937989; RA Sugamori K.S., Demchyshyn L.L., Chung M., Niznik H.B.; RT "D1A, D1B, and D1C dopamine receptors from Xenopus laevis."; RL Proc. Natl. Acad. Sci. U.S.A. 91:10536-10540(1994). CC -!- FUNCTION: THIS IS ONE OF THE FIVE TYPES (D1 TO D5) OF RECEPTORS CC FOR DOPAMINE. THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G CC PROTEINS WHICH ACTIVATE ADENYLYL CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain and kidney. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U07865; AAA50830.1; -. DR PIR; I51661; I51661. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 30 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 31 54 1 (POTENTIAL). FT DOMAIN 55 65 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 66 92 2 (POTENTIAL). FT DOMAIN 93 101 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 102 124 3 (POTENTIAL). FT DOMAIN 125 143 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 144 168 4 (POTENTIAL). FT DOMAIN 169 193 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 194 219 5 (POTENTIAL). FT DOMAIN 220 264 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 265 291 6 (POTENTIAL). FT DOMAIN 292 309 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 310 334 7 (POTENTIAL). FT DOMAIN 335 465 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 3 3 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 101 187 BY SIMILARITY. FT LIPID 344 344 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 465 AA; 52640 MW; F41DF85AF0D2F869 CRC64; MENFSIFNVT VNVWHADLDV GNSDLSLRAL TGLLLSLLIL STLLGNTLVC LAVIKFRHLR SKVTNFFVIS LAVSDLFVAL LVMPWKAVTE VAGFWVFGDF CDTWVAFDIM CSTASILNLC IISLDRYWAI ASPFRYERKM TQRVAFIMIG VAWTLSILIS FIPVQLSWHK SHEADEELNG VNHTENCDSS LNRTYAISSS LISFYIPVVI MIGTYTRIYR IAQTQIRRIS SLERAVEHAQ RCSSRLSNEN SLKTSFRKET KVLKTLSIIM GVFVFCWLPF FVLNCMIPFC HMNLPGQNEP EPPCVSETTF NIFVWFGWAN SSLNPVIYAF NADFRKAFTT ILGCNRFCSS NNVEAVNFSN ELVSYHHDTT FQKDIPVTFN NSHLPNVVDQ DQEVLEGTCF DKVSVLSTSH GTRSQKNLHL PAGVQFECEA EITLETITPF TSTGPLECLP QLVADEDRHY TTKLY // ID 5H2A_HUMAN STANDARD; PRT; 471 AA. AC P28223; DT 01-DEC-1992 (Rel. 24, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 2A receptor (5-HT-2A) (Serotonin receptor 2A) DE (5-HT-2). GN HTR2A OR HTR2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain stem; RX MEDLINE=92109767; PubMed=1722404; RA Saltzman A.G., Morse B., Whitman M.M., Ivanshchenko Y., Jaye M., RA Felder S.; RT "Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes."; RL Biochem. Biophys. Res. Commun. 181:1469-1478(1991). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=92356792; PubMed=1323014; RA Chen K., Yang W., Grimsby J., Shih J.C.; RT "The human 5-HT2 receptor is encoded by a multiple intron-exon gene."; RL Brain Res. Mol. Brain Res. 14:20-26(1992). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=94308772; PubMed=8035173; RA Cook E.H. Jr., Fletcher K.E., Wainwright M., Marks N., Yan S.Y., RA Leventhal B.L.; RT "Primary structure of the human platelet serotonin 5-HT2A receptor: RT identify with frontal cortex serotonin 5-HT2A receptor."; RL J. Neurochem. 63:465-469(1994). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE OF 9-464 FROM N.A. RC TISSUE=Brain; RA Tritch R.J., Robinson D.L., Sahagan B.G., Horlick R.A.; RT "Cloning and nucleotide sequence of the human(5HT) type 2 receptor."; RL Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE OF 105-218 FROM N.A. RX MEDLINE=93049882; PubMed=1330647; RA Stam N.J., van Huizen F., van Alebeek C., Brands J., Dijkema R., RA Tonnaer J.A., Olijve W.; RT "Genomic organization, coding sequence and functional expression of RT human 5-HT2 and 5-HT1A receptor genes."; RL Eur. J. Pharmacol. 227:153-162(1992). RN [7] RP VARIANTS ASN-25 AND TYR-452. RX MEDLINE=96209907; PubMed=8655141; RA Erdmann J., Shimron-Abarbanell D., Rietschel M., Albus M., Maier W., RA Koerner J., Bondy B., Chen K., Shih J.C., Knapp M., Propping P., RA Noethen M.M.; RT "Systematic screening for mutations in the human serotonin-2A RT (5-HT2A) receptor gene: identification of two naturally occurring RT receptor variants and association analysis in schizophrenia."; RL Hum. Genet. 97:614-619(1996). RN [8] RP VARIANTS ASN-25 AND TYR-452. RX MEDLINE=20049881; PubMed=10581480; RA Marshall S.E., Bird T.G., Hart K., Welsh K.I.; RT "Unified approach to the analysis of genetic variation in serotonergic RT pathways."; RL Am. J. Med. Genet. 88:621-627(1999). RN [9] RP VARIANTS VAL-197; VAL-447 AND TYR-452. RX MEDLINE=99318093; PubMed=10391209; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [10] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. This receptor CC mediates its action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. This CC receptor is involved in tracheal smooth muscle contraction, CC bronchoconstriction, and control of aldosterone production. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of g-protein coupled receptors. CC Strongest to the other 5HT-2 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S42168; AAB22791.2; -. DR EMBL; S42165; AAB22791.2; JOINED. DR EMBL; S42167; AAB22791.2; JOINED. DR EMBL; X57830; CAA40963.1; -. DR EMBL; S71229; AAB31320.1; -. DR EMBL; AF498982; AAM21129.1; -. DR EMBL; S50130; AAB24166.2; -. DR EMBL; S49737; AAB24166.2; JOINED. DR EMBL; S50113; AAB24166.2; JOINED. DR EMBL; M86841; AAA58354.1; -. DR PIR; A43956; A43956. DR HSSP; P08913; 1HLL. DR Genew; HGNC:5293; HTR2A. DR MIM; 182135; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007210; P:serotonin receptor signaling pathway; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00516; 5HT2ARECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Polymorphism. FT DOMAIN 1 75 Extracellular (Potential). FT TRANSMEM 76 99 1 (Potential). FT DOMAIN 100 110 Cytoplasmic (Potential). FT TRANSMEM 111 132 2 (Potential). FT DOMAIN 133 147 Extracellular (Potential). FT TRANSMEM 148 171 3 (Potential). FT DOMAIN 172 191 Cytoplasmic (Potential). FT TRANSMEM 192 215 4 (Potential). FT DOMAIN 216 233 Extracellular (Potential). FT TRANSMEM 234 254 5 (Potential). FT DOMAIN 255 324 Cytoplasmic (Potential). FT TRANSMEM 325 346 6 (Potential). FT DOMAIN 347 362 Extracellular (Potential). FT TRANSMEM 363 384 7 (Potential). FT DOMAIN 385 471 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). FT CARBOHYD 44 44 N-linked (GlcNAc...) (Potential). FT CARBOHYD 51 51 N-linked (GlcNAc...) (Potential). FT CARBOHYD 54 54 N-linked (GlcNAc...) (Potential). FT DISULFID 148 227 By similarity. FT VARIANT 25 25 T -> N (in dbSNP:1805055). FT /FTId=VAR_003448. FT VARIANT 197 197 I -> V (in dbSNP:6304). FT /FTId=VAR_013901. FT VARIANT 447 447 A -> V (in dbSNP:6308). FT /FTId=VAR_013902. FT VARIANT 452 452 H -> Y (in dbSNP:6314). FT /FTId=VAR_003449. SQ SEQUENCE 471 AA; 52603 MW; EF8AAC0BC5379DA2 CRC64; MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK QHSEEASKDN SDGVNEKVSC V // ID 5H1F_CAVPO STANDARD; PRT; 366 AA. AC O08890; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 1F receptor (5-HT-1F) (Serotonin receptor 1F) (5- DE HT1F). GN HTR1F. OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Liver; RX MEDLINE=97368668; PubMed=9225282; RA Adham N., Bard J.A., Zgombick J.M., Durkin M.M., Kucharewicz S., RA Weinshank R.L., Branchek T.A.; RT "Cloning and characterization of the guinea pig 5-HT1F receptor RT subtype: a comparison of the pharmacological profile to the human RT species homolog."; RL Neuropharmacology 36:569-576(1997). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Strongest to the other 5HT-1 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U80852; AAB58496.1; -. DR HSSP; P08913; 1HLL. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00515; 5HT1FRECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 48 1 (Potential). FT DOMAIN 49 60 Cytoplasmic (Potential). FT TRANSMEM 61 83 2 (Potential). FT DOMAIN 84 94 Extracellular (Potential). FT TRANSMEM 95 119 3 (Potential). FT DOMAIN 120 139 Cytoplasmic (Potential). FT TRANSMEM 140 161 4 (Potential). FT DOMAIN 162 178 Extracellular (Potential). FT TRANSMEM 179 202 5 (Potential). FT DOMAIN 203 291 Cytoplasmic (Potential). FT TRANSMEM 292 314 6 (Potential). FT DOMAIN 315 327 Extracellular (Potential). FT TRANSMEM 328 351 7 (Potential). FT DOMAIN 352 366 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT DISULFID 96 172 By similarity. SQ SEQUENCE 366 AA; 41839 MW; FE4200E2DA26C9C3 CRC64; MDFLNSSDQN LTSEELLHRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVLCDIWL SVDIICCTCS ILHLSAIALD RYRAITDAVE YARKRTPKQA GIMITIVWII SVFISMPPLF WRHQGTSRDD ECIIKHDHIV STIYSTFGAF YIPLVLILIL YYKIYKAAKT LYHKRQASRI AKEELNGQVL LESGEKSIKM VSTTYVPEKS LSDPSTDFDK IHNTVKSPRC KLRHEKSWRR QKISGTRERK AATTLGLILG AFVICWLPFF VKELVVNVCE KCKISEEMAN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK LVRCQY // ID 5H2A_MACMU STANDARD; PRT; 471 AA. AC P50128; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 2A receptor (5-HT-2A) (Serotonin receptor 2A) DE (5-HT-2). GN HTR2A. OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95315240; PubMed=7794950; RA Johnson M.P., Baez M., Kursar J.D., Nelson D.L.; RT "Species differences in 5-HT2A receptors: cloned pig and rhesus RT monkey 5-HT2A receptors reveal conserved transmembrane homology to RT the human rather than rat sequence."; RL Biochim. Biophys. Acta 1236:201-206(1995). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. This receptor CC mediates its action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. This CC receptor is involved in tracheal smooth muscle contraction, CC bronchoconstriction, and control of aldosterone production. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of g-protein coupled receptors. CC Strongest to the other 5HT-2 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S78209; AAB34691.1; -. DR HSSP; P08913; 1HLL. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00516; 5HT2ARECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 75 Extracellular (Potential). FT TRANSMEM 76 99 1 (Potential). FT DOMAIN 100 110 Cytoplasmic (Potential). FT TRANSMEM 111 132 2 (Potential). FT DOMAIN 133 147 Extracellular (Potential). FT TRANSMEM 148 171 3 (Potential). FT DOMAIN 172 191 Cytoplasmic (Potential). FT TRANSMEM 192 215 4 (Potential). FT DOMAIN 216 233 Extracellular (Potential). FT TRANSMEM 234 254 5 (Potential). FT DOMAIN 255 324 Cytoplasmic (Potential). FT TRANSMEM 325 346 6 (Potential). FT DOMAIN 347 362 Extracellular (Potential). FT TRANSMEM 363 384 7 (Potential). FT DOMAIN 385 471 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). FT CARBOHYD 44 44 N-linked (GlcNAc...) (Potential). FT CARBOHYD 51 51 N-linked (GlcNAc...) (Potential). FT CARBOHYD 54 54 N-linked (GlcNAc...) (Potential). FT DISULFID 148 227 By similarity. SQ SEQUENCE 471 AA; 52603 MW; 300FFC84DE03D462 CRC64; MDILCEENTS LSSTTNSLMQ LNEDTRLYSN DFNSGEANTS DAFNWTVESE NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH RDPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK QHSEDASKDN SDGVNEKVSC V // ID ACM1_DROME STANDARD; PRT; 722 AA. AC P16395; DT 01-AUG-1990 (Rel. 15, Created) DT 01-AUG-1990 (Rel. 15, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Muscarinic acetylcholine receptor DM1. GN ACRC OR MACR-60C. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Oregon-R; RX MEDLINE=90046926; PubMed=2510174; RA Shapiro R.A., Wakimoto B.T., Subers E.M., Nathanson N.M.; RT "Characterization and functional expression in mammalian cells of RT genomic and cDNA clones encoding a Drosophila muscarinic RT acetylcholine receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 86:9039-9043(1989). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=90005981; PubMed=2507354; RA Onai T., Fitzgerald M.G., Arakawa S., Gocayne J.D., Urquhart D.A., RA Hall L.M., Fraser C.M., McCombie W.R., Venter J.C.; RT "Cloning, sequence analysis and chromosome localization of a RT Drosophila muscarinic acetylcholine receptor."; RL FEBS Lett. 255:219-225(1989). CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is PI turnover. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M27495; AAA85449.1; -. DR EMBL; M23412; AAA28676.1; ALT_INIT. DR PIR; S05661; S05661. DR FlyBase; FBgn0000037; mAcR-60C. DR GO; GO:0005886; C:plasma membrane; NAS. DR GO; GO:0004981; F:muscarinic acetylcholine receptor activity; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Postsynaptic membrane; Glycoprotein; Transmembrane; Phosphorylation; KW Multigene family; G-protein coupled receptor. FT DOMAIN 1 26 Extracellular (Potential). FT TRANSMEM 27 49 1 (Potential). FT DOMAIN 50 60 Cytoplasmic (Potential). FT TRANSMEM 61 81 2 (Potential). FT DOMAIN 82 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 140 Cytoplasmic (Potential). FT TRANSMEM 141 162 4 (Potential). FT DOMAIN 163 184 Extracellular (Potential). FT TRANSMEM 185 208 5 (Potential). FT DOMAIN 209 634 Cytoplasmic (Potential). FT TRANSMEM 635 656 6 (Potential). FT DOMAIN 657 672 Extracellular (Potential). FT TRANSMEM 673 693 7 (Potential). FT DOMAIN 694 722 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CONFLICT 75 75 T -> A (in Ref. 2). FT CONFLICT 119 119 N -> S (in Ref. 2). FT CONFLICT 136 136 G -> R (in Ref. 2). FT CONFLICT 147 147 A -> AA (in Ref. 2). FT CONFLICT 250 250 P -> G (in Ref. 2). FT CONFLICT 346 362 Missing (in Ref. 2). FT CONFLICT 381 381 G -> A (in Ref. 2). FT CONFLICT 451 451 T -> A (in Ref. 2). FT CONFLICT 606 606 C -> VG (in Ref. 2). FT CONFLICT 614 614 P -> AR (in Ref. 2). FT CONFLICT 654 656 VLI -> CXS (in Ref. 1). FT CONFLICT 688 688 S -> C (in Ref. 2). FT CONFLICT 714 722 EGMVRGVYN -> DFYAASTIR (in Ref. 1). SQ SEQUENCE 722 AA; 78237 MW; FB35417CB2202A61 CRC64; MYGNQTNGTI GFETKGPRYS LASMVVMGFV AAILSTVTVA GNVMVMISFK IDKQLQTISN YFLFSLAIAD FAIGTISMPL FAVTTILGYW PLGPIVCDTW LALDYLASNA SVLNLLIINF DRYFSVTRPL TYRAKGTTNR AAVMIGAWGI SLLLWPPWIY SWPYIEGKRT VPKDECYIQF IETNQYITFG TALAAFYFPV TIMCFLYWRI WRETKKRQKD LPNLQAGKKD SSKRSNSSDE NTVVNHASGP LLAFAQVGGN DHDTWRRPRS ESSADAESVY MTNMVIDSGY HGMHSRKSSI KSTNTIKKSY TCFGSIKEWC IAWWHSGRED SDDFAYEQEE PSDLGYATPV TIETPLQSSV SRCTSMNVMR DNYSMGGSVS GVRPPSILLS DVSPTPLPRP PLASISQLQE MSAVTASTTA NVNTSGNGNG AINNNNNASH NGNGAVNGNG TGNGSGIGLG TTGNATHRDS RTLPVINRIN SRSVSQDSVY TILIRLPSDG ASSNAANGGG GGPGAGAAAS ASLSMQGDCA PSIKMIHEDG PTTTAAAAPL ASAAATRRPL PSRDSEFSLP LGRRMSHAQH DARLLNAKVI PKQLGKAGGG AAGGGCGAHA LMNPNAAKKK KKSQEKRQES KAAKTLSAIL LSFIITWTPY NILVLIKPLT TCSDCIPTEL WDFFYALCYI NSTINPMSYA LCNATFRRTY VRILTCKWHT RNREGMVRGV YN // ID 5H1E_HUMAN STANDARD; PRT; 365 AA. AC P28566; Q9P1Y1; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 1E receptor (5-HT-1E) (Serotonin receptor 1E) (5- DE HT1E) (S31). GN HTR1E. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=92302274; PubMed=1608964; RA McAllister G., Charlesworth A., Snodin C., Beer M.S., Noble A.J., RA Middlemiss D.N., Iversen L.L., Whiting P.; RT "Molecular cloning of a serotonin receptor from human brain (5HT1E): RT a fifth 5HT1-like subtype."; RL Proc. Natl. Acad. Sci. U.S.A. 89:5517-5521(1992). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=92128546; PubMed=1733778; RA Levy F.O., Gudermann T., Birnbaumer M., Kaumann A.J., Birnbaumer L.; RT "Molecular cloning of a human gene (S31) encoding a novel serotonin RT receptor mediating inhibition of adenylyl cyclase."; RL FEBS Lett. 296:201-206(1992). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=92382553; PubMed=1513320; RA Zgombick J.M., Schechter L.E., Macchi M., Hartig P.R., RA Branchek T.A., Weinshank R.L.; RT "Human gene S31 encodes the pharmacologically defined serotonin 5- RT hydroxytryptamine1E receptor."; RL Mol. Pharmacol. 42:180-185(1992). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE FROM N.A. RA Tromans A.; RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE OF 1-363 FROM N.A. RA Kitano T., Kobayakawa H., Saitou N.; RT "Silver project."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. RN [7] RP VARIANT PHE-262. RX MEDLINE=99318093; PubMed=10391209; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [8] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Strongest to the other 5HT-1 subtype receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M91467; AAA58353.1; -. DR EMBL; Z11166; CAA77558.1; -. DR EMBL; M92826; AAA58355.1; -. DR EMBL; AF498980; AAM21127.1; -. DR EMBL; AL157777; CAC10582.1; -. DR EMBL; AB041373; BAA94458.1; -. DR PIR; S20579; A45260. DR HSSP; P08913; 1HLL. DR Genew; HGNC:5291; HTR1E. DR MIM; 182132; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00515; 5HT1FRECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Polymorphism. FT DOMAIN 1 22 Extracellular (Potential). FT TRANSMEM 23 47 1 (Potential). FT DOMAIN 48 59 Cytoplasmic (Potential). FT TRANSMEM 60 81 2 (Potential). FT DOMAIN 82 96 Extracellular (Potential). FT TRANSMEM 97 118 3 (Potential). FT DOMAIN 119 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT DOMAIN 160 179 Extracellular (Potential). FT TRANSMEM 180 201 5 (Potential). FT DOMAIN 202 291 Cytoplasmic (Potential). FT TRANSMEM 292 314 6 (Potential). FT DOMAIN 315 324 Extracellular (Potential). FT TRANSMEM 325 347 7 (Potential). FT DOMAIN 348 365 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT DISULFID 95 173 By similarity. FT VARIANT 262 262 S -> F (in dbSNP:6303). FT /FTId=VAR_014165. SQ SEQUENCE 365 AA; 41682 MW; 4C31DD783A3F7483 CRC64; MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT KKLHQPANYL ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS VDMTCCTCSI LHLCVIALDR YWAITNAIEY ARKRTAKRAA LMILTVWTIS IFISMPPLFW RSHRRLSPPP SQCTIQHDHV IYTIYSTLGA FYIPLTLILI LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ TFCVSDFSTS DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED FKLAFKKLIR CREHT // ID 5H5B_MOUSE STANDARD; PRT; 370 AA. AC P31387; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE 5-hydroxytryptamine 5B receptor (5-HT-5B) (Serotonin receptor 5B). GN HTR5B OR 5HT5B. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=93196607; PubMed=8450829; RA Matthes H., Boschert U., Amlaiky N., Grailhe R., Plassat J.-L., RA Muscatelli F., Mattei M.-G., Hen R.; RT "Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors RT define a new family of serotonin receptors: cloning, functional RT expression, and chromosomal localization."; RL Mol. Pharmacol. 43:313-319(1993). CC -!- FUNCTION: This is one of the several different receptors for CC 5-hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins. Probably involved in CC anxiety and depression. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed predominantly in the central nervous CC system; in the hippocampus, habenula, and the doral raphe. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC STRONGEST TO THE OTHER 5HT-5 SUBTYPE RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X69867; CAA49501.1; -. DR PIR; I48231; I48231. DR HSSP; P08913; 1HLL. DR MGD; MGI:96284; Htr5b. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00519; 5HT5BRECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 52 Extracellular (Potential). FT TRANSMEM 53 75 1 (Potential). FT DOMAIN 76 90 Cytoplasmic (Potential). FT TRANSMEM 91 111 2 (Potential). FT DOMAIN 112 128 Extracellular (Potential). FT TRANSMEM 129 150 3 (Potential). FT DOMAIN 151 171 Cytoplasmic (Potential). FT TRANSMEM 172 194 4 (Potential). FT DOMAIN 195 211 Extracellular (Potential). FT TRANSMEM 212 232 5 (Potential). FT DOMAIN 233 295 Cytoplasmic (Potential). FT TRANSMEM 296 316 6 (Potential). FT DOMAIN 317 333 Extracellular (Potential). FT TRANSMEM 334 354 7 (Potential). FT DOMAIN 355 370 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT DISULFID 127 205 By similarity. SQ SEQUENCE 370 AA; 41201 MW; 0553C62B12DAAD84 CRC64; MEVSNLSGAT PGLAFPPGPE SCSDSPSSGR SMGSTPGGLI LPGREPPFSA FTVLVVTLLV LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL VAVLVMPLSL VSELSAGRRW QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL DRYWTITRHL QYTLRTRSRA SALMIAITWA LSALIALAPL LFGWGEAYDA RLQRCQVSQE PSYAVFSTCG AFYLPLAVVL FVYWKIYKAA KFRFGRRRRA VVPLPATTQA KEAPPESEMV FTARRRATVT FQTSGDSWRE QKEKRAAMMV GILIGVFVLC WIPFFLTELI SPLCACSLPP IWKSIFLWLG YSNSFFNPLI YTAFNKNYNN AFKSLFTKQR // ID TAR3_HUMAN STANDARD; PRT; 348 AA. AC Q96RI9; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Trace amine receptor 3 (TaR-3). GN TRAR3 OR TAR3 OR TA3. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21374364; PubMed=11459929; DOI=10.1073/pnas.151105198; RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., RA Branchek T.A., Gerald C.; RT "Trace amines: identification of a family of mammalian G protein- RT coupled receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001). RN [2] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Trace amines are biogenic amines present in very low levels in CC mammalian tissues. Although some trace amines have clearly defined CC roles as neurotransmitters in invertebrates, the extent to which CC they function as true neurotransmitters in vertebrates has CC remained speculative. Trace amines are likely to be involved in a CC variety of physiological functions that have yet to be fully CC understood. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF380189; AAK71240.1; -. DR EMBL; AY183469; AAO24660.1; -. DR Genew; HGNC:20977; TRAR3. DR MIM; 608282; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01831; TRACEAMINE1R. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 58 1 (Potential). FT DOMAIN 59 68 Cytoplasmic (Potential). FT TRANSMEM 69 89 2 (Potential). FT DOMAIN 90 106 Extracellular (Potential). FT TRANSMEM 107 128 3 (Potential). FT DOMAIN 129 147 Cytoplasmic (Potential). FT TRANSMEM 148 168 4 (Potential). FT DOMAIN 169 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT DOMAIN 219 259 Cytoplasmic (Potential). FT TRANSMEM 260 280 6 (Potential). FT DOMAIN 281 294 Extracellular (Potential). FT TRANSMEM 295 315 7 (Potential). FT DOMAIN 316 348 Cytoplasmic (Potential). FT DISULFID 105 190 By similarity. FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 348 AA; 39016 MW; D0C6484880A6F761 CRC64; MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN LLVMIAILHF KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF GDSYCKFHTC FDTSFCFASL FHLCCISVDR YIAVTDPLTY PTKFTVSVSG ICIVLSWFFS VTYSFSIFYT GANEEGIEEL VVALTCVGGC QAPLNQNWVL LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS SSESYKERVA KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD // ID TAR5_HUMAN STANDARD; PRT; 342 AA. AC Q969N4; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Trace amine receptor 5 (TaR-5) (G protein-coupled receptor GPR102). GN TRAR5 OR GPR102 OR TAR5 OR TA5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A., AND TISSUE SPECIFICITY. RX MEDLINE=21374364; PubMed=11459929; DOI=10.1073/pnas.151105198; RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., RA Branchek T.A., Gerald C.; RT "Trace amines: identification of a family of mammalian G protein- RT coupled receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21458557; PubMed=11574155; RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.; RT "Discovery and mapping of ten novel G protein-coupled receptor RT genes."; RL Gene 275:83-91(2001). RN [3] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Trace amines are biogenic amines present in very low levels in CC mammalian tissues. Although some trace amines have clearly defined CC roles as neurotransmitters in invertebrates, the extent to which CC they function as true neurotransmitters in vertebrates has CC remained speculative. Trace amines are likely to be involved in a CC variety of physiological functions that have yet to be fully CC understood. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in kidney and amygdala. Not CC expressed in other tissues or brain regions tested. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF380193; AAK71244.1; -. DR EMBL; AF411116; AAL26487.1; -. DR EMBL; AY183468; AAO24659.1; -. DR Genew; HGNC:14964; TRAR5. DR MIM; 606927; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 31 Extracellular (Potential). FT TRANSMEM 32 52 1 (Potential). FT DOMAIN 53 67 Cytoplasmic (Potential). FT TRANSMEM 68 88 2 (Potential). FT DOMAIN 89 111 Extracellular (Potential). FT TRANSMEM 112 132 3 (Potential). FT DOMAIN 133 146 Cytoplasmic (Potential). FT TRANSMEM 147 167 4 (Potential). FT DOMAIN 168 195 Extracellular (Potential). FT TRANSMEM 196 216 5 (Potential). FT DOMAIN 217 258 Cytoplasmic (Potential). FT TRANSMEM 259 279 6 (Potential). FT DOMAIN 280 280 Extracellular (Potential). FT TRANSMEM 281 301 7 (Potential). FT DOMAIN 302 342 Cytoplasmic (Potential). FT DISULFID 104 189 By similarity. FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 342 AA; 38028 MW; AB034E68F7D60388 CRC64; MTSNFSQPVV QLCYEDVNGS CIETPYSPGS RVILYTAFSF GSLLAVFGNL LVMTSVLHFK QLHSPTNFLI ASLACADFLV GVTVMLFSMV RTVESCWYFG AKFCTLHSCC DVAFCYSSVL HLCFICIDRY IVVTDPLVYA TKFTVSVSGI CISVSWILPL TYSGAVFYTG VNDDGLEELV SALNCVGGCQ IIVSQGWVLI DFLLFFIPTL VMIILYSKIF LIAKQQAIKI ETTSSKVESS SESYKIRVAK RERKAAKTLG VTVLAFVISW LPYTVDILID AFMGFLTPAY IYEICCWSAY YNSAMNPLIY ALFYPWFRKA IKLILSGDVL KASSSTISLF LE // ID TAR1_MACMU STANDARD; PRT; 338 AA. AC Q8HZ64; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Trace amine receptor 1 (TaR-1). GN TRAR1 OR TAR1 OR TA1. OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP SEQUENCE FROM N.A. RA Miller G.M., Madras B.K.; RT "Cloning of trace amine receptor 1 (TAR1) from Rhesus monkey."; RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Activated by endogenous trace amines as well as metabolites of the CC biogenic amine neurotransmitters (By similarity). Trace amines are CC biogenic amines present in very low levels in mammalian tissues. CC Although some trace amines have clearly defined roles as CC neurotransmitters in invertebrates, the extent to which they CC function as true neurotransmitters in vertebrates has remained CC speculative. Trace amines are likely to be involved in a variety CC of physiological functions that have yet to be fully understood. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY135366; AAN06172.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01831; TRACEAMINE1R. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 24 Extracellular (Potential). FT TRANSMEM 25 45 1 (Potential). FT DOMAIN 46 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT DOMAIN 80 97 Extracellular (Potential). FT TRANSMEM 98 118 3 (Potential). FT DOMAIN 119 135 Cytoplasmic (Potential). FT TRANSMEM 136 156 4 (Potential). FT DOMAIN 157 187 Extracellular (Potential). FT TRANSMEM 188 208 5 (Potential). FT DOMAIN 209 251 Cytoplasmic (Potential). FT TRANSMEM 252 272 6 (Potential). FT DOMAIN 273 286 Extracellular (Potential). FT TRANSMEM 287 307 7 (Potential). FT DOMAIN 308 338 Cytoplasmic (Potential). FT DISULFID 95 181 By similarity. FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 338 AA; 38797 MW; 9EE7B35456BB409B CRC64; MPFCHNIINI SCVKNNWSND VRASLYSLMA LIILTTLVGN LIVIVSISHF KQLHTPTNWL IHSMATVDFL LGCLVMPYSM VRSAEHCWYF GEVFCKIHTS TDIMLSSASI FHLSFISIDR YYAVCDPLRY KAKINILVVC VMIFISWSVP AVFAFGMIFL ELNFKGAEEI YYKHVHCRGG CSVFFSKISG VLAFMTSFYI PGSIMLCIYY RIYLIAKEQA RSINDANQKL QIGLEMKNGI SQSKERKAVK TLGIVMGVFL ICWCPFFVCT VIDPFLHYTI PPTLNDVLIW FGYLNSTFNP MVYAFFYPWF RKALKMILFG KIFQKDSSRC KLFLESSS // ID CKR5_HYLLE STANDARD; PRT; 352 AA. AC O97883; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5). GN CCR5 OR CMKBR5. OS Hylobates leucogenys (White-cheeked gibbon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hylobatidae; Hylobates. OX NCBI_TaxID=61853; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99416438; PubMed=10486970; RA Zhang Y.-W., Ryder O.A., Zhang Y.-P.; RT "Sequence evolution of the CCR5 chemokine receptor gene in primates."; RL Mol. Biol. Evol. 16:1145-1154(1999). CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, CC MIP-1-beta and RANTES and subsequently transduces a signal by CC increasing the intracellular calcium ions level. May play a role CC in the control of granulocytic lineage proliferation or CC differentiation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF075451; AAD19863.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Sulfation. FT DOMAIN 1 30 Extracellular (Potential). FT TRANSMEM 31 58 1 (Potential). FT DOMAIN 59 68 Cytoplasmic (Potential). FT TRANSMEM 69 89 2 (Potential). FT DOMAIN 90 102 Extracellular (Potential). FT TRANSMEM 103 124 3 (Potential). FT DOMAIN 125 141 Cytoplasmic (Potential). FT TRANSMEM 142 166 4 (Potential). FT DOMAIN 167 198 Extracellular (Potential). FT TRANSMEM 199 218 5 (Potential). FT DOMAIN 219 235 Cytoplasmic (Potential). FT TRANSMEM 236 260 6 (Potential). FT DOMAIN 261 277 Extracellular (Potential). FT TRANSMEM 278 301 7 (Potential). FT DOMAIN 302 352 Cytoplasmic (Potential). FT DISULFID 101 178 By similarity. FT MOD_RES 3 3 Sulfotyrosine (By similarity). FT MOD_RES 10 10 Sulfotyrosine (By similarity). FT MOD_RES 14 14 Sulfotyrosine (By similarity). SQ SEQUENCE 352 AA; 40445 MW; 4F8E4F344CEB7C91 CRC64; MDYQVSSPTY DIDYDTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILVLINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII LLTIDRYLAI VHAVFALKAR TVTFGVVTSV ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV GEKFRNYLLV FFQKHIAKHF CKCCSIFQQE APERASSVYT RSTGEQEISV GL // ID CKR5_PANPA STANDARD; PRT; 352 AA. AC P60574; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5). GN CCR5 OR CMKBR5. OS Pan paniscus (Pygmy chimpanzee) (Bonobo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9597; RN [1] RP SEQUENCE FROM N.A. RA Zhang Y., Ryder O.A., Zhang Y.; RT "Sequence comparison of the CCR5 gene in primates and primate RT phylogeny."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, CC MIP-1-beta and RANTES and subsequently transduces a signal by CC increasing the intracellular calcium ions level. May play a role CC in the control of granulocytic lineage proliferation or CC differentiation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF177893; AAK43376.1; -. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Sulfation. FT DOMAIN 1 30 Extracellular (Potential). FT TRANSMEM 31 58 1 (Potential). FT DOMAIN 59 68 Cytoplasmic (Potential). FT TRANSMEM 69 89 2 (Potential). FT DOMAIN 90 102 Extracellular (Potential). FT TRANSMEM 103 124 3 (Potential). FT DOMAIN 125 141 Cytoplasmic (Potential). FT TRANSMEM 142 166 4 (Potential). FT DOMAIN 167 198 Extracellular (Potential). FT TRANSMEM 199 218 5 (Potential). FT DOMAIN 219 235 Cytoplasmic (Potential). FT TRANSMEM 236 260 6 (Potential). FT DOMAIN 261 277 Extracellular (Potential). FT TRANSMEM 278 301 7 (Potential). FT DOMAIN 302 352 Cytoplasmic (Potential). FT DISULFID 101 178 By similarity. FT MOD_RES 3 3 Sulfotyrosine (By similarity). FT MOD_RES 10 10 Sulfotyrosine (By similarity). FT MOD_RES 14 14 Sulfotyrosine (By similarity). FT MOD_RES 15 15 Sulfotyrosine (By similarity). FT CARBOHYD 268 268 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 352 AA; 40539 MW; 4A33E698B80FE34C CRC64; MDYQVSSPIY DIDYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII LLTIDRYLAI VHAVFALKAR TVTFGVVTSV ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL // ID CKR2_RAT STANDARD; PRT; 373 AA. AC O55193; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2). GN CCR2 OR CMKBR2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=98318173; PubMed=9655467; RA Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., RA deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.; RT "Chemokine receptor expression in cultured glia and rat experimental RT allergic encephalomyelitis."; RL J. Neuroimmunol. 86:1-12(1998). CC -!- FUNCTION: RECEPTOR FOR THE MCP-1 (JE), MCP-3 (FIC) AND MCP-5 CC CHEMOKINES. TRANSDUCES A SIGNAL BY INCREASING THE INTRACELLULAR CC CALCIUM IONS LEVEL (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: EXPRESSED IN LUNG, SPLEEN, KIDNEY, THYMUS AND CC MACROPHAGES. CC -!- INDUCTION: IN ANIMALS IN WHICH EXPERIMENTAL ALLERGIC CC ENCEPHALOMYELITIS (EAE) HAS BEEN INDUCED. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U77349; AAC03242.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane. FT DOMAIN 1 60 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 61 81 POTENTIAL. FT DOMAIN 82 91 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 92 112 POTENTIAL. FT DOMAIN 113 128 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 129 149 POTENTIAL. FT DOMAIN 150 170 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 171 191 POTENTIAL. FT DOMAIN 192 220 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 221 241 POTENTIAL. FT DOMAIN 242 256 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 257 277 POTENTIAL. FT DOMAIN 278 301 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 302 322 POTENTIAL. FT DOMAIN 323 373 CYTOPLASMIC (POTENTIAL). FT DISULFID 126 203 BY SIMILARITY. SQ SEQUENCE 373 AA; 42763 MW; 2E7BB012F5D6FD09 CRC64; MEDSNMLPQF IHGILSTSHS LFPRSIQELD EGATTPYDYD DGEPCHKTSV KQIGAWILPP LYSLVFIFGF VGNMLVIIIL ISCKKLKSMT DIYLFNLAIS DLLFLLTLPF WAHYAANEWV FGNIMCKLFT GLYHIGYFGG IFFIILLTID RYLAIVHAVF ALKARTVTFG VITSVVTWVV AVFASLPGII FTKSEQEDDQ HTCGPYFPTI WKNFQTIMRN ILSLILPLLV MVICYSGILH TLFRCRNEKK RHRAVRLIFA IMIVYFLFWT PYNIVLFLTT FQEFLGMSNC VVDMHLDQAM QVTETLGMTH CCVNPIIYAF VGEKFRRYLS IFFRKHIAKN LCKQCPVFYR ETADRVSSTF TPSTGEQEVS VGL // ID CKR1_MACMU STANDARD; PRT; 355 AA. AC P56482; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1). GN CCR1 OR CMKBR1. OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21354176; PubMed=11461684; RA Margulies B.J., Hauer D.A., Clements J.E.; RT "Identification and comparison of eleven rhesus macaque chemokine RT receptors."; RL AIDS Res. Hum. Retroviruses 17:981-986(2001). CC -!- FUNCTION: RECEPTOR FOR A C-C TYPE CHEMOKINE. BINDS TO MIP-1-ALPHA, CC RANTES, MCP-3 AND, LESS EFFICIENTLY, TO MIP-1-BETA OR MCP-1 AND CC SUBSEQUENTLY TRANSDUCES A SIGNAL BY INCREASING THE INTRACELLULAR CC CALCIUM IONS LEVEL. RESPONSIBLE FOR AFFECTING STEM CELL CC PROLIFERATION. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF017282; AAB70526.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 34 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 35 60 1 (POTENTIAL). FT DOMAIN 61 64 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 65 91 2 (POTENTIAL). FT DOMAIN 92 107 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 108 129 3 (POTENTIAL). FT DOMAIN 130 146 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 147 171 4 (POTENTIAL). FT DOMAIN 172 197 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 198 223 5 (POTENTIAL). FT DOMAIN 224 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 264 6 (POTENTIAL). FT DOMAIN 265 281 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 282 305 7 (POTENTIAL). FT DOMAIN 306 355 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 106 183 BY SIMILARITY. SQ SEQUENCE 355 AA; 41198 MW; 41CAEA7CC19D23D4 CRC64; METPNTTEDY DMITEFDYGD ATPCHKVNER AILAQLLPPL YSLVFVIGVV GNLLVVLVLV QYKRLKNMTN IYLLNLAISD LLFLFTLPFL IYYKSTDDWI FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASSPLMY FSKTQWNIVR HSCNIHFPYE SFQQWKLFQA LKLNLFGLVL PLLVMIVCYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL FWTPYNLTEL ISVFQEFLFT HLCEQNRQLD LAMEVTEVIA NMHCCVNPVI YAFAGERFRK YLRQLFHRRV AVHLVKWLPF LSGDRLERVS STSPSTGEHE LSAGF // ID CKR4_HUMAN STANDARD; PRT; 360 AA. AC P51679; Q9ULY6; Q9ULY7; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) DE (K5-5). GN CCR4 OR CMKBR4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Spleen; RX MEDLINE=95370289; PubMed=7642634; RA Power C.A., Meyer A., Nemeth K., Bacon K.B., Hoogewerf A.J., RA Proudfoot A.E.I., Wells T.N.C.; RT "Molecular cloning and functional expression of a novel CC chemokine RT receptor cDNA from a human basophilic cell line."; RL J. Biol. Chem. 270:19495-19500(1995). RN [2] RP SEQUENCE FROM N.A., AND VARIANTS VAL-130 AND SER-178. RX MEDLINE=21040311; PubMed=11196669; RA Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., RA Hirai K., Tokunaga K.; RT "New variations of human CC-chemokine receptors CCR3 and CCR4."; RL Genes Immun. 1:97-104(1999). RN [3] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP FUNCTION. RX MEDLINE=97313486; PubMed=9169480; RA Imai T., Baba M., Nishimura M., Kakizaki M., Takagi S., Yoshie O.; RT "The T cell-directed CC chemokine TARC is a highly specific RT biological ligand for CC chemokine receptor 4."; RL J. Biol. Chem. 272:15036-15042(1997). RN [5] RP FUNCTION. RX MEDLINE=98104168; PubMed=9430724; RA Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., RA Yoshie O., Gray P.W.; RT "Macrophage-derived chemokine is a functional ligand for the CC RT chemokine receptor 4."; RL J. Biol. Chem. 273:1764-1768(1998). RN [6] RP FUNCTION. RX MEDLINE=99394604; PubMed=10466728; RA Campbell J.J., Haraldsen G., Pan J., Rottman J., Qin S., Ponath P., RA Andrew D.P., Warnke R., Ruffing N., Kassam N., Wu L., Butcher E.C.; RT "The chemokine receptor CCR4 in vascular recognition by cutaneous but RT not intestinal memory T cells."; RL Nature 400:776-780(1999). RN [7] RP FUNCTION, TISSUE SPECIFICITY, AND PHOSPHORYLATION. RX MEDLINE=20219238; PubMed=10754297; RA Inngjerdingen M., Damaj B., Maghazachi A.A.; RT "Human NK cells express CC chemokine receptors 4 and 8 and respond to RT thymus and activation-regulated chemokine, macrophage-derived RT chemokine, and I-309."; RL J. Immunol. 164:4048-4054(2000). CC -!- FUNCTION: High affinity receptor for the C-C type chemokines CC TARC/SCYA17 and MDC/SCYA22. The activity of this receptor is CC mediated by G(i) proteins which activate a phosphatidylinositol- CC calcium second messenger system. Can function as a chemoattractant CC homing receptor on circulating memory lymphocytes and as a CC coreceptor for some primary HIV-2 isolates. In the CNS, could CC mediate hippocampal-neuron survival. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Predominantly expressed in the thymus, in CC peripheral blood leukocytes, including T cells, mostly CD4+ cells, CC and basophils, and in platelets; at lower levels, in the spleen CC and in monocytes. Detected also in macrophages, IL-2-activated CC natural killer cells and skin-homing memory T cells, mostly the CC ones expressing the cutaneous lymphocyte antigen (CLA). Expressed CC in brain microvascular and coronary artery endothelial cells. CC -!- PTM: In natural killer cells, SCYA22 binding induces CC phosphorylation on yet undefined Ser/Thr residues, most probably CC by beta-adrenergic receptor kinases 1 and 2. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X85740; CAA59743.1; -. DR EMBL; AB023888; BAA86965.1; -. DR EMBL; AB023889; BAA86966.1; -. DR EMBL; AB023890; BAA86967.1; -. DR EMBL; AB023891; BAA86968.1; -. DR EMBL; AB023892; BAA86969.1; -. DR EMBL; AY322539; AAP84352.1; -. DR PIR; A57160; A57160. DR Genew; HGNC:1605; CCR4. DR MIM; 604836; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007204; P:cytosolic calcium ion concentration elevation; TAS. DR GO; GO:0006955; P:immune response; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Polymorphism. FT DOMAIN 1 39 Extracellular (Potential). FT TRANSMEM 40 67 1 (Potential). FT DOMAIN 68 77 Cytoplasmic (Potential). FT TRANSMEM 78 98 2 (Potential). FT DOMAIN 99 111 Extracellular (Potential). FT TRANSMEM 112 133 3 (Potential). FT DOMAIN 134 150 Cytoplasmic (Potential). FT TRANSMEM 151 175 4 (Potential). FT DOMAIN 176 206 Extracellular (Potential). FT TRANSMEM 207 226 5 (Potential). FT DOMAIN 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 267 6 (Potential). FT DOMAIN 268 284 Extracellular (Potential). FT TRANSMEM 285 308 7 (Potential). FT DOMAIN 309 360 Cytoplasmic (Potential). FT CARBOHYD 183 183 N-linked (GlcNAc...) (Potential). FT CARBOHYD 194 194 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 By similarity. FT VARIANT 130 130 L -> V. FT /FTId=VAR_010669. FT VARIANT 178 178 C -> S. FT /FTId=VAR_010670. SQ SEQUENCE 360 AA; 41402 MW; 51EBE12AD1FAFABF CRC64; MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF VFGLLGNSVV VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA DQWVFGLGLC KMISWMYLVG FYSGIFFVML MSIDRYLAIV HAVFSLRART LTYGVITSLA TWSVAVFASL PGFLFSTCYT ERNHTYCKTK YSLNSTTWKV LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA VKMIFAVVVL FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS TMDHDLHDAL // ID AG2R_PANTR STANDARD; PRT; 359 AA. AC Q9GLN9; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Type-1 angiotensin II receptor (AT1). GN AGTR1. OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20469400; PubMed=11013071; RA Dufour C., Casane D., Denton D., Wickings J., Corvol P., RA Jeunemaitre X.; RT "Human-chimpanzee DNA sequence variation in the four major genes of RT the renin angiotensin system."; RL Genomics 69:14-26(2000). CC -!- FUNCTION: Receptor for angiotensin II. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF193445; AAG28410.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00635; ANGIOTENSN1R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 52 1 (Potential). FT DOMAIN 53 64 Cytoplasmic (Potential). FT TRANSMEM 65 87 2 (Potential). FT DOMAIN 88 102 Extracellular (Potential). FT TRANSMEM 103 124 3 (Potential). FT DOMAIN 125 142 Cytoplasmic (Potential). FT TRANSMEM 143 162 4 (Potential). FT DOMAIN 163 192 Extracellular (Potential). FT TRANSMEM 193 214 5 (Potential). FT DOMAIN 215 240 Cytoplasmic (Potential). FT TRANSMEM 241 262 6 (Potential). FT DOMAIN 263 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT DOMAIN 297 359 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 176 176 N-linked (GlcNAc...) (Potential). FT CARBOHYD 188 188 N-linked (GlcNAc...) (Potential). FT DISULFID 101 180 By similarity. FT LIPID 355 355 S-palmitoyl cysteine (Potential). SQ SEQUENCE 359 AA; 41033 MW; 266133A7A3E911A6 CRC64; MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL FYGFLGKKFK KYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE // ID CKRV_MOUSE STANDARD; PRT; 356 AA. AC P51676; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE C-C chemokine receptor 1-like protein 1 (Macrophage inflammatory DE protein-1 alpha receptor-like 1). GN CCR1L1 OR CMKBR1L1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=129/SvJ; RX MEDLINE=95340546; PubMed=7542241; RA Gao J.-L., Murphy P.M.; RT "Cloning and differential tissue-specific expression of three mouse RT beta chemokine receptor-like genes, including the gene for a RT functional macrophage inflammatory protein-1 alpha receptor."; RL J. Biol. Chem. 270:17494-17501(1995). CC -!- FUNCTION: PROBABLE RECEPTOR FOR A C-C TYPE CHEMOKINE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: DETECTED IN THE SPLEEN, LIVER AND LEUKOCYTES. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U28405; AAA89154.1; -. DR MGD; MGI:104617; Ccr1l1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane. FT DOMAIN 1 32 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 33 60 1 (POTENTIAL). FT DOMAIN 61 67 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 68 92 2 (POTENTIAL). FT DOMAIN 93 108 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 109 130 3 (POTENTIAL). FT DOMAIN 131 147 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 148 172 4 (POTENTIAL). FT DOMAIN 173 198 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 199 224 5 (POTENTIAL). FT DOMAIN 225 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 265 6 (POTENTIAL). FT DOMAIN 266 282 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 283 306 7 (POTENTIAL). FT DOMAIN 307 356 CYTOPLASMIC (POTENTIAL). FT DISULFID 107 184 BY SIMILARITY. SQ SEQUENCE 356 AA; 40934 MW; 58C01ABA8D7D4B06 CRC64; MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVPTP LYSLVFIIGV IGHVLVVLVL IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW IFGNAMCKFV SGFYYLGLYS DMFFITLLTI DRYLAVVHVV FALRARTVTF GIISSIITWV LAALVSIPCL YVFKSQMEFT YHTCRAILPR KSLIRFLRFQ ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR LIFVITLLFF LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSEDRAQRA SARLPSTVEI ETSADL // ID AG2S_MOUSE STANDARD; PRT; 359 AA. AC P29755; DT 01-APR-1993 (Rel. 25, Created) DT 01-APR-1993 (Rel. 25, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Type-1B angiotensin II receptor (AT1B) (AT3). GN AGTR1B. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BALB/c; TISSUE=Liver; RX MEDLINE=92287102; PubMed=1599461; RA Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., RA Dzau V.J.; RT "Cloning, characterization, and expression of two angiotensin RT receptor (AT-1) isoforms from the mouse genome."; RL Biochem. Biophys. Res. Commun. 185:253-259(1992). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=92359981; PubMed=1497638; RA Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., RA van der Meer-De Jong R., Inagami T., Ichikawa I.; RT "Analysis of the evolution of angiotensin II type 1 receptor gene in RT mammals (mouse, rat, bovine and human)."; RL Biochem. Biophys. Res. Commun. 186:1042-1049(1992). CC -!- FUNCTION: Receptor for angiotensin II. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S37491; AAB22270.1; -. DR PIR; JC1194; JC1194. DR HSSP; P34996; 1DDD. DR MGD; MGI:87965; Agtr1b. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 27 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 28 52 1 (POTENTIAL). FT DOMAIN 53 64 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 65 87 2 (POTENTIAL). FT DOMAIN 88 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 124 3 (POTENTIAL). FT DOMAIN 125 142 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 143 162 4 (POTENTIAL). FT DOMAIN 163 192 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 193 214 5 (POTENTIAL). FT DOMAIN 215 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 262 6 (POTENTIAL). FT DOMAIN 263 275 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 276 296 7 (POTENTIAL). FT DOMAIN 297 359 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 176 176 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 188 188 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 101 180 BY SIMILARITY. FT LIPID 355 355 S-palmitoyl cysteine (Potential). FT CONFLICT 7 7 I -> T (IN REF. 2). FT CONFLICT 166 166 H -> Y (IN REF. 2). FT CONFLICT 173 173 E -> A (IN REF. 2). FT CONFLICT 205 205 V -> E (IN REF. 2). FT CONFLICT 232 232 T -> I (IN REF. 2). FT CONFLICT 239 239 F -> G (IN REF. 2). SQ SEQUENCE 359 AA; 40949 MW; 95730F97058EAA4B CRC64; MILNSSIEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYQWPFGNHL CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESQNST LPIGLGLTKN ILGFVFPFVI ILTSYTLIWK ALKKAYKIQK NTPRNDDIFR IIMAIVLFFF FSWVPHQIFS FLDVLIQLGV IHDCEIADVV DTAMPITICI AYFNNCLNPL FYGFLGKKFK RYFLQLLKYI PPKARSHAGL STKMSTLSYR PSDNMSSSAR KSAYCFEVE // ID C3X1_MOUSE STANDARD; PRT; 354 AA. AC Q9Z0D9; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Fractalkine DE receptor). GN CX3CR1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=129/Sv; RX MEDLINE=99119076; PubMed=9918795; RA Combadiere C., Gao J.-L., Tiffany H.L., Murphy P.M.; RT "Gene cloning, RNA distribution, and functional expression of mCX3CR1, RT a mouse chemotactic receptor for the CX3C chemokine fractalkine."; RL Biochem. Biophys. Res. Commun. 253:728-732(1998). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=129/SvJ; RA Coultas L., McColl S.R.; RT "Cloning and characterization of murine CX3CR1, a receptor for murine RT fractalkine/neurotactin."; RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RC STRAIN=Czech II; TISSUE=Mammary gland; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for the CX3C chemokine fractalkine and mediates CC both its adhesive and migratory functions. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: This protein is not N-glycosylated which is unusual for CC G-protein-coupled receptors. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF074912; AAD08665.1; -. DR EMBL; AF102269; AAC72408.1; -. DR EMBL; BC012653; AAH12653.1; -. DR MGD; MGI:1333815; Cx3cr1. DR InterPro; IPR005387; Fractalkiner. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01562; FRACTALKINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane. FT DOMAIN 1 32 Extracellular (Potential). FT TRANSMEM 33 60 1 (Potential). FT DOMAIN 61 70 Cytoplasmic (Potential). FT TRANSMEM 71 91 2 (Potential). FT DOMAIN 92 104 Extracellular (Potential). FT TRANSMEM 105 126 3 (Potential). FT DOMAIN 127 143 Cytoplasmic (Potential). FT TRANSMEM 144 168 4 (Potential). FT DOMAIN 169 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT DOMAIN 217 232 Cytoplasmic (Potential). FT TRANSMEM 233 257 6 (Potential). FT DOMAIN 258 274 Extracellular (Potential). FT TRANSMEM 275 298 7 (Potential). FT DOMAIN 299 354 Cytoplasmic (Potential). FT DISULFID 103 176 By similarity. SQ SEQUENCE 354 AA; 40266 MW; 12C745E8E3755CA9 CRC64; MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN LLVVLALTNS RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEMWPV LRNSEVNILG FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA FFLFWTPYNI MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG SLLL // ID IL8B_RABIT STANDARD; PRT; 358 AA. AC P35344; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE HIGH AFFINITY INTERLEUKIN-8 RECEPTOR B (IL-8R B) (CXCR-2) (GRO/MGSA DE RECEPTOR). GN IL8RB OR CXCR2. OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Lagomorpha; Leporidae; Oryctolagus. OX NCBI_TaxID=9986; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=ALBINO; TISSUE=Blood; RX MEDLINE=94230294; PubMed=8175642; RA Prado G.N., Thomas K.M., Suzuki H., Larosa G.J., Wilkinson N.C., RA Folco E., Navarro J.; RT "Molecular characterization of a novel rabbit interleukin-8 receptor RT isotype."; RL J. Biol. Chem. 269:12391-12394(1994). CC -!- FUNCTION: RECEPTOR TO INTERLEUKIN-8, WHICH IS A POWERFUL CC NEUTROPHILS CHEMOTACTIC FACTOR. BINDING OF IL-8 TO THE RECEPTOR CC CAUSES ACTIVATION OF NEUTROPHILS. THIS RESPONSE IS MEDIATED VIA A CC G-PROTEIN THAT ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND CC MESSENGER SYSTEM. THE AFFINITY OF THIS RECEPTOR IS IL-8 >> NAP-2 > CC MGSA (GRO). CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: EXPRESSED PREFERENTIALLY IN NEUTROPHILS. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L24445; AAA31378.1; -. DR PIR; A53752; A53752. DR GCRDb; GCR_0861; -. DR InterPro; IPR000057; -. DR InterPro; IPR000174; -. DR InterPro; IPR000276; -. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00427; INTRLEUKIN8R. DR PRINTS; PR00573; INTRLEUKN8BR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Chemotaxis. FT DOMAIN 1 46 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 47 73 1 (POTENTIAL). FT DOMAIN 74 82 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 83 103 2 (POTENTIAL). FT DOMAIN 104 118 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 119 140 3 (POTENTIAL). FT DOMAIN 141 161 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 162 181 4 (POTENTIAL). FT DOMAIN 182 206 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 207 229 5 (POTENTIAL). FT DOMAIN 230 249 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 250 271 6 (POTENTIAL). FT DOMAIN 272 292 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 293 313 7 (POTENTIAL). FT DOMAIN 314 358 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 20 20 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 117 194 BY SIMILARITY. SQ SEQUENCE 358 AA; 40632 MW; 6899716944D6126A CRC64; MQEFTWENYS YEDFFGDFSN YSYSTDLPPT LLDSAPCRSE SLETNSYVVL ITYILVFLLS LLGNSLVMLV ILYSRSTCSV TDVYLLNLAI ADLLFATTLP IWAASKVHGW TFGTPLCKVV SLVKEVNFYS GILLLACISV DRYLAIVHAT RTMIQKRHLV KFICLSMWGV SLILSLPILL FRNAIFPPNS SPVCYEDMGN STAKWRMVLR ILPQTFGFIL PLLVMLFCYV FTLRTLFQAH MGQKHRAMRV IFAVVLIFLL CWLPYNLVLL TDTLMRTHVI QETCERRNDI DRALDATEIL GFLHSCLNPI IYAFIGQKFR YGLLKILAAH GLISKEFLAK ESRPSFVASS SGNTSTTL // ID IL8B_BOVIN STANDARD; PRT; 360 AA. AC Q28003; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE High affinity interleukin-8 receptor B (IL-8R B) (CXCR-2). GN IL8RB OR CXCR2. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RA Li Y., Feng J., Templeton J.W.; RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: RECEPTOR TO INTERLEUKIN-8, WHICH IS A POWERFUL CC NEUTROPHILS CHEMOTACTIC FACTOR. BINDING OF IL-8 TO THE RECEPTOR CC CAUSES ACTIVATION OF NEUTROPHILS. THIS RESPONSE IS MEDIATED VIA A CC G-PROTEIN THAT ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND CC MESSENGER SYSTEM. THIS RECEPTOR BINDS TO IL-8 WITH A HIGH AFFINITY CC AND TO GRO/MGSA AND NAP-2 ALSO WITH A HIGH AFFINITY (BY CC SIMILARITY). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U19947; AAA84996.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Chemotaxis. FT DOMAIN 1 48 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 49 75 1 (POTENTIAL). FT DOMAIN 76 84 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 85 105 2 (POTENTIAL). FT DOMAIN 106 120 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 121 142 3 (POTENTIAL). FT DOMAIN 143 163 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 164 183 4 (POTENTIAL). FT DOMAIN 184 208 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 209 231 5 (POTENTIAL). FT DOMAIN 232 251 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 252 273 6 (POTENTIAL). FT DOMAIN 274 294 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 295 315 7 (POTENTIAL). FT DOMAIN 316 360 CYTOPLASMIC (POTENTIAL). FT DISULFID 119 196 BY SIMILARITY. FT CARBOHYD 10 10 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 24 24 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 360 AA; 40625 MW; 9A7F70C982A632D1 CRC64; MTIILKDLSN SSILWEGFED EFGNYSGTPP TEDYDYSPCE ISTETLNKYA VVVIDALVFL LSLLGNSLVM LVILYSRIGR SVTDVYLLNL AMADLLFAMT LPIWTASKAK GWVFGTPLCK VVSLLKEVNF YSGILLLACI SMDRYLAIVH ATRTLTQKWH WVKFICLGIW ALSVILALPI FIFREAYQPP YSDLVCYEDL GANTTKWRMI MRVLPQTFGF LLPLLVMLFC YGFTLRTLFS AQMGHKHRAM RVIFAVVLVF LLCWLPYNLV LIADTLMRAH VIAETCQRRN DIGRALDATE ILGFLHSCLN PLIYVFIGQK FRHGLLKIMA IHGLISKEFL AKDGRPSFVG SSSGNTSTTL // ID OPRD_HUMAN STANDARD; PRT; 372 AA. AC P41143; DT 01-FEB-1995 (Rel. 31, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Delta-type opioid receptor (DOR-1). GN OPRD1 OR OPRD. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain cortex, and Striatum; RX MEDLINE=94260835; PubMed=8201839; RA Knapp R.J., Malatynska E., Fang L., Li X., Babin E., Nguyen M., RA Santoro G., Varga E.V., Hruby V.J., Roeske W.R., Yamamura H.I.; RT "Identification of a human delta opioid receptor: cloning and RT expression."; RL Life Sci. 54:PL463-PL469(1994). RN [2] RP REVISIONS TO 40-41; 348 AND 370. RA Knapp R.J.; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A., AND VARIANT CYS-27. RX MEDLINE=95107267; PubMed=7808419; RA Simonin F., Befort K., Gaveriaux-Ruff C., Matthes H., Nappey V., RA Lannes B., Micheletti G., Kieffer B.; RT "The human delta-opioid receptor: genomic organization, cDNA cloning, RT functional expression, and distribution in human brain."; RL Mol. Pharmacol. 46:1015-1021(1994). RN [4] RP SEQUENCE FROM N.A., AND VARIANT CYS-27. RA Grafham D.; RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases. RN [5] RP VARIANT CYS-27. RX MEDLINE=20434920; PubMed=10982041; RA Gelernter J., Kranzler H.R.; RT "Variant detection at the delta opioid receptor (OPRD1) locus and RT population genetics of a novel variant affecting protein sequence."; RL Hum. Genet. 107:86-88(2000). CC -!- FUNCTION: Inhibits neurotransmitter release by reducing calcium CC ion currents and increasing potassium ion conductance. Highly CC stereoselective. receptor for enkephalins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U07882; AAA18789.2; -. DR EMBL; U10504; AAA83426.1; -. DR EMBL; AL009181; CAA15671.1; -. DR PIR; I38532; I38532. DR Genew; HGNC:8153; OPRD1. DR MIM; 165195; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004986; F:delta-opioid receptor activity; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0006955; P:immune response; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate; Polymorphism. FT DOMAIN 1 45 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 46 75 1 (POTENTIAL). FT DOMAIN 76 84 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 85 102 2 (POTENTIAL). FT DOMAIN 103 124 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 125 144 3 (POTENTIAL). FT DOMAIN 145 174 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 175 190 4 (POTENTIAL). FT DOMAIN 191 215 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 216 238 5 (POTENTIAL). FT DOMAIN 239 261 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 262 284 6 (POTENTIAL). FT DOMAIN 285 293 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 294 310 7 (POTENTIAL). FT DOMAIN 311 372 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 33 33 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 121 198 BY SIMILARITY. FT LIPID 333 333 S-palmitoyl cysteine (Potential). FT VARIANT 27 27 F -> C (in dbSNP:1042114). FT /FTId=VAR_012083. SQ SEQUENCE 372 AA; 40412 MW; 83D84893EEA4AFD3 CRC64; MEPAPSAGAE LQPPLFANAS DAYPSAFPSA GANASGPPGA RSASSLALAI AITALYSAVC AVGLLGNVLV MFGIVRYTKM KTATNIYIFN LALADALATS TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTR PRDGAVVCML QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDID RRDPLVVAAL HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRKPCGRP DPSSFSRARE ATARERVTAC TPSDGPGGGA AA // ID SSR1_RAT STANDARD; PRT; 391 AA. AC P28646; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Somatostatin receptor type 1 (SS1R) (SRIF-2). GN SSTR1. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Wistar; TISSUE=Brain; RX MEDLINE=92096119; PubMed=1661599; RA Meyerhof W., Paust H.J., Schoenrock C., Richter D.; RT "Cloning of a cDNA encoding a novel putative G-protein-coupled RT receptor expressed in specific rat brain regions."; RL DNA Cell Biol. 10:689-694(1991). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=93016064; PubMed=1400442; RA Li X.-J., Forte M., North R.A., Ross C.A., Snyder S.H.; RT "Cloning and expression of a rat somatostatin receptor enriched in RT brain."; RL J. Biol. Chem. 267:21307-21312(1992). CC -!- FUNCTION: Receptor for somatostatin with higher affinity for CC somatostatin-14 than -28. This receptor is coupled to CC phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis CC toxin insensitive G proteins. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain, pituitary, islet, jejunum, stomach, CC heart, spleen. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X62314; CAA44193.1; -. DR EMBL; M97656; -; NOT_ANNOTATED_CDS. DR PIR; A39297; A39297. DR RGD; 3762; Sstr1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00587; SOMATOSTTN1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 56 Extracellular (Potential). FT TRANSMEM 57 84 1 (Potential). FT DOMAIN 85 94 Cytoplasmic (Potential). FT TRANSMEM 95 120 2 (Potential). FT DOMAIN 121 131 Extracellular (Potential). FT TRANSMEM 132 153 3 (Potential). FT DOMAIN 154 175 Cytoplasmic (Potential). FT TRANSMEM 176 196 4 (Potential). FT DOMAIN 197 219 Extracellular (Potential). FT TRANSMEM 220 244 5 (Potential). FT DOMAIN 245 270 Cytoplasmic (Potential). FT TRANSMEM 271 296 6 (Potential). FT DOMAIN 297 303 Extracellular (Potential). FT TRANSMEM 304 327 7 (Potential). FT DOMAIN 328 391 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 44 44 N-linked (GlcNAc...) (Potential). FT CARBOHYD 48 48 N-linked (GlcNAc...) (Potential). FT DISULFID 130 208 By similarity. FT LIPID 339 339 S-palmitoyl cysteine (Potential). SQ SEQUENCE 391 AA; 42746 MW; 28ED6E894B72FBB7 CRC64; MFPNGTAPSP TSSPSSSPGG CGEGVCSRGP GSGAADGMEE PGRNSSQNGT LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCASRIST L // ID SSR1_HUMAN STANDARD; PRT; 391 AA. AC P30872; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Somatostatin receptor type 1 (SS1R) (SRIF-2). GN SSTR1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=92108031; PubMed=1346068; RA Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.; RT "Cloning and functional characterization of a family of human and RT mouse somatostatin receptors expressed in brain, gastrointestinal RT tract, and kidney."; RL Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992). RN [2] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP INTERACTION WITH SKB1. RX MEDLINE=20200451; PubMed=10734105; RA Schwaerzler A., Kreienkamp H.-J., Richter D.; RT "Interaction of the somatostatin receptor subtype 1 with the human RT homolog of the Shk1 kinase-binding protein from yeast."; RL J. Biol. Chem. 275:9557-9562(2000). CC -!- FUNCTION: Receptor for somatostatin with higher affinity for CC somatostatin-14 than -28. This receptor is coupled via pertussis CC toxin sensitive G proteins to inhibition of adenylyl cyclase. In CC addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) CC exchanger via pertussis toxin insensitive G proteins. CC -!- SUBUNIT: Interacts with SKB1. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Fetal kidney, fetal liver, and adult pancreas, CC brain, lung, jejunum and stomach. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M81829; AAA58247.1; -. DR EMBL; AY322536; AAP84349.1; -. DR EMBL; BC035618; AAH35618.1; -. DR PIR; A41795; A41795. DR Genew; HGNC:11330; SSTR1. DR MIM; 182451; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004994; F:somatostatin receptor activity; TAS. DR GO; GO:0007166; P:cell surface receptor linked signal transdu...; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0007586; P:digestion; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0008285; P:negative regulation of cell proliferation; TAS. DR GO; GO:0007584; P:response to nutrients; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00587; SOMATOSTTN1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 56 Extracellular (Potential). FT TRANSMEM 57 84 1 (Potential). FT DOMAIN 85 94 Cytoplasmic (Potential). FT TRANSMEM 95 120 2 (Potential). FT DOMAIN 121 131 Extracellular (Potential). FT TRANSMEM 132 153 3 (Potential). FT DOMAIN 154 175 Cytoplasmic (Potential). FT TRANSMEM 176 196 4 (Potential). FT DOMAIN 197 219 Extracellular (Potential). FT TRANSMEM 220 244 5 (Potential). FT DOMAIN 245 270 Cytoplasmic (Potential). FT TRANSMEM 271 296 6 (Potential). FT DOMAIN 297 303 Extracellular (Potential). FT TRANSMEM 304 327 7 (Potential). FT DOMAIN 328 391 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 44 44 N-linked (GlcNAc...) (Potential). FT CARBOHYD 48 48 N-linked (GlcNAc...) (Potential). FT DISULFID 130 208 By similarity. FT LIPID 339 339 S-palmitoyl cysteine (Potential). SQ SEQUENCE 391 AA; 42686 MW; 85C99AFFF339A43D CRC64; MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCTSRITT L // ID CKD6_MOUSE STANDARD; PRT; 378 AA. AC O08707; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Chemokine binding protein 2 (Chemokine-binding protein D6) (C-C DE chemokine receptor D6). GN CCBP2 OR D6. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=C3H; RX MEDLINE=97284722; PubMed=9139699; RA Nibbs R.J., Wylie S.M., Pragnell I.B., Graham G.J.; RT "Cloning and characterization of a novel murine beta chemokine RT receptor, D6. Comparison to three other related macrophage RT inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5."; RL J. Biol. Chem. 272:12495-12504(1997). CC -!- FUNCTION: Receptor for C-C type chemokines including SCY3/MIP1- CC alpha and SCYA4/MIP-1-beta. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y12879; CAA73379.1; -. DR MGD; MGI:1891697; Ccbp2. DR GO; GO:0016493; F:C-C chemokine receptor activity; IDA. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0007165; P:signal transduction; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 49 Extracellular (Potential). FT TRANSMEM 50 70 1 (Potential). FT DOMAIN 71 91 Cytoplasmic (Potential). FT TRANSMEM 92 112 2 (Potential). FT DOMAIN 113 117 Extracellular (Potential). FT TRANSMEM 118 139 3 (Potential). FT DOMAIN 140 161 Cytoplasmic (Potential). FT TRANSMEM 162 182 4 (Potential). FT DOMAIN 183 216 Extracellular (Potential). FT TRANSMEM 217 237 5 (Potential). FT DOMAIN 238 249 Cytoplasmic (Potential). FT TRANSMEM 250 270 6 (Potential). FT DOMAIN 271 292 Extracellular (Potential). FT TRANSMEM 293 313 7 (Potential). FT DOMAIN 314 378 Cytoplasmic (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 116 194 By similarity. SQ SEQUENCE 378 AA; 43255 MW; 7A125FF3C7B2F5E0 CRC64; MPTVASPLPL TTVGSENSSS IYDYDYLDDM TILVCRKDEV LSFGRVFLPV VYSLIFVLGL AGNLLLLVVL LHSAPRRRTM ELYLLNLAVS NLLFVVTMPF WAISVAWHWV FGSFLCKVIS TLYSINFYCG IFFITCMSLD KYLEIVHAQP LHRPKAQFRN LLLIVMVWIT SLAISVPEMV FVQIHQTLDG VWHCYADFGG HATIWKLYLR FQLNLLGFLL PLLAMIFFYS RIGCVLVRLR PPGQGRALRM AAALVIVFFM LWFPYYLTLF LHSLLDLHVF GNCEISHRLD YTLQVTESLA FSHCCFTPVL YAFCSHRFRR YLKAFLSVML RWHQAPGTPS SNHSESSRVT AQEDVVSMND LGERQSEDSL NKGEMGNT // ID CCR6_MACNE STANDARD; PRT; 342 AA. AC O19024; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE C-X-C chemokine receptor type 6 (CXC-R6) (CXCR-6) (G protein-coupled DE receptor bonzo). GN CXCR6 OR BONZO. OS Macaca nemestrina (Pig-tailed macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9545; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97373958; PubMed=9230441; RA Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.; RT "Expression cloning of new receptors used by simian and human RT immunodeficiency viruses."; RL Nature 388:296-300(1997). CC -!- FUNCTION: RECEPTOR FOR THE C-X-C CHEMOKINE CXCL16. USED AS A CC CORECEPTOR BY SIVS AND BY STRAINS OF HIV-2 AND M-TROPIC HIV-1. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF007858; AAB64224.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 32 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 33 59 1 (POTENTIAL). FT DOMAIN 60 68 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 69 89 2 (POTENTIAL). FT DOMAIN 90 103 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 104 125 3 (POTENTIAL). FT DOMAIN 126 143 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 144 164 4 (POTENTIAL). FT DOMAIN 165 187 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 188 215 5 (POTENTIAL). FT DOMAIN 216 231 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 232 259 6 (POTENTIAL). FT DOMAIN 260 275 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 276 293 7 (POTENTIAL). FT DOMAIN 294 342 CYTOPLASMIC (POTENTIAL). FT DISULFID 102 180 BY SIMILARITY. FT CARBOHYD 16 16 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 342 AA; 39297 MW; 55F9F68CB62D2DF5 CRC64; MAEHDYHEDY GLNSFNDSSQ EEHQDFLQFR KVFLPCMYLV VFVCGLVGNS LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWIFGQV MCKTLLGVYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKRMTWGKV ICLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDKEISTV VLATQMTLGF FLPLLAMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQTPFNLV KLIRSTHWEY YAMTSFHYTI IVTEAIAYLR ACLNPVLYAF VSLKFRKNFW KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL // ID CCR6_CERAE STANDARD; PRT; 342 AA. AC O18983; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE C-X-C chemokine receptor type 6 (CXC-R6) (CXCR-6) (G protein-coupled DE receptor bonzo). GN CXCR6 OR BONZO. OS Cercopithecus aethiops (Green monkey) (Grivet). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Cercopithecus. OX NCBI_TaxID=9534; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97373958; PubMed=9230441; RA Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.; RT "Expression cloning of new receptors used by simian and human RT immunodeficiency viruses."; RL Nature 388:296-300(1997). CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a CC coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF007859; AAB64225.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 32 Extracellular (Potential). FT TRANSMEM 33 59 1 (Potential). FT DOMAIN 60 68 Cytoplasmic (Potential). FT TRANSMEM 69 89 2 (Potential). FT DOMAIN 90 103 Extracellular (Potential). FT TRANSMEM 104 125 3 (Potential). FT DOMAIN 126 143 Cytoplasmic (Potential). FT TRANSMEM 144 164 4 (Potential). FT DOMAIN 165 187 Extracellular (Potential). FT TRANSMEM 188 215 5 (Potential). FT DOMAIN 216 231 Cytoplasmic (Potential). FT TRANSMEM 232 259 6 (Potential). FT DOMAIN 260 275 Extracellular (Potential). FT TRANSMEM 276 293 7 (Potential). FT DOMAIN 294 342 Cytoplasmic (Potential). FT DISULFID 102 180 By similarity. FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 342 AA; 39226 MW; 6CBFE389C6E5919E CRC64; MAEYDHYEDN GFNSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWIFGQV MCKTLLGIYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKKMTWGKV ICLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDEEISTV VLATQMTLGF FLPLLAMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQTPFNLV KLIRSTHWEY YAMTSFHYTI IVTEAIAYLR ACLNPVLYAF VSLKFRKNFW KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL // ID CCR6_HUMAN STANDARD; PRT; 342 AA. AC O00574; O00575; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE C-X-C chemokine receptor type 6 (CXC-R6) (CXCR-6) (G protein-coupled DE receptor bonzo) (G protein-coupled receptor STRL33). GN CXCR6 OR BONZO OR STRL33 OR TYMSTR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97373958; PubMed=9230441; RA Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.; RT "Expression cloning of new receptors used by simian and human RT immunodeficiency viruses."; RL Nature 388:296-300(1997). RN [2] RP SEQUENCE FROM N.A., AND VARIANT ALA-25. RX MEDLINE=97311099; PubMed=9166430; RA Liao F., Alkhatib G., Peden K.W.C., Sharma G., Berger E.A., RA Farber J.M.; RT "STRL33, A novel chemokine receptor-like protein, functions as a RT fusion cofactor for both macrophage-tropic and T cell line-tropic RT HIV-1."; RL J. Exp. Med. 185:2015-2023(1997). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Blood; RX MEDLINE=97431687; PubMed=9285716; RA Loetscher M., Amara A., Oberlin E., Brass N., Legler D.F., RA Loetscher P., D'Apuzzo M., Meese E.U., Rousset D., Virelizier J.L., RA Baggiolini M., Arenzana-Seisdedos F., Moser B.; RT "TYMSTR, a putative chemokine receptor selectively expressed in RT activated T cells, exhibits HIV-1 coreceptor function."; RL Curr. Biol. 7:652-660(1997). RN [4] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Pancreas; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a CC coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in lymphoid tissues and activated T CC cells. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF007545; AAB64221.1; -. DR EMBL; U73529; AAB61456.1; -. DR EMBL; U73531; AAB61457.1; -. DR EMBL; Y13248; CAA73698.1; -. DR EMBL; AY322543; AAP84356.1; -. DR EMBL; BC033584; AAH33584.1; -. DR Genew; HGNC:16647; CXCR6. DR MIM; 605163; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0015026; F:coreceptor activity; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0019079; P:viral genome replication; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Polymorphism. FT DOMAIN 1 32 Extracellular (Potential). FT TRANSMEM 33 59 1 (Potential). FT DOMAIN 60 68 Cytoplasmic (Potential). FT TRANSMEM 69 89 2 (Potential). FT DOMAIN 90 103 Extracellular (Potential). FT TRANSMEM 104 125 3 (Potential). FT DOMAIN 126 143 Cytoplasmic (Potential). FT TRANSMEM 144 164 4 (Potential). FT DOMAIN 165 187 Extracellular (Potential). FT TRANSMEM 188 215 5 (Potential). FT DOMAIN 216 231 Cytoplasmic (Potential). FT TRANSMEM 232 259 6 (Potential). FT DOMAIN 260 275 Extracellular (Potential). FT TRANSMEM 276 293 7 (Potential). FT DOMAIN 294 342 Cytoplasmic (Potential). FT DISULFID 102 180 By similarity. FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). FT VARIANT 25 25 D -> A (in STRL33.3). FT /FTId=VAR_003506. SQ SEQUENCE 342 AA; 39280 MW; 9FBC025556D1082E CRC64; MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV MCKSLLGIYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKRMTWGKV TSLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDEAISTV VLATQMTLGF FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQMPFNLM KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL // ID CCR6_MACFA STANDARD; PRT; 343 AA. AC Q9BDS6; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE C-X-C chemokine receptor type 6 (CXC-R6) (CXCR-6) (G protein-coupled DE receptor bonzo) (G protein-coupled receptor STRL33). GN CXCR6 OR BONZO OR STRL33. OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21134756; PubMed=11242524; RA Wade-Evans A.M., Russell J., Jenkins A., Javan C.; RT "Cloning and sequencing of cynomolgus macaque ccr3, gpr15, and strl33: RT potential coreceptors for HIV type 1, HIV type 2, and SIV."; RL AIDS Res. Hum. Retroviruses 17:371-375(2001). CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a CC coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF291671; AAK25742.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 33 Extracellular (Potential). FT TRANSMEM 34 60 1 (Potential). FT DOMAIN 61 69 Cytoplasmic (Potential). FT TRANSMEM 70 90 2 (Potential). FT DOMAIN 91 104 Extracellular (Potential). FT TRANSMEM 105 126 3 (Potential). FT DOMAIN 127 144 Cytoplasmic (Potential). FT TRANSMEM 145 165 4 (Potential). FT DOMAIN 166 188 Extracellular (Potential). FT TRANSMEM 189 216 5 (Potential). FT DOMAIN 217 232 Cytoplasmic (Potential). FT TRANSMEM 233 260 6 (Potential). FT DOMAIN 261 276 Extracellular (Potential). FT TRANSMEM 277 294 7 (Potential). FT DOMAIN 295 343 Cytoplasmic (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 103 181 By similarity. SQ SEQUENCE 343 AA; 39472 MW; 0961328F948E7784 CRC64; MAEYDHYEDD GFLNSFNDSS QEEHQDFLQF RKVFLPCMYL VVFVCGLVGN SLVLVISIFY HKLQSLTDVF LVNLPLADLV FVCTLPFWTY AGIHEWIFGQ VMCKTLLGVY TINFYTSMLI LTCITVDRFI VVVKATKAYN QQAKRMTWGK VICLLIWVIS LLVSLPQIIY GNVFNLDKLI CGYHDEEIST VVLATQMTLG FFLPLLAMIV CYSVIIKTLL HAGGFQKHRS LKIIFLVMAV FLLTQTPFNL VKLIRSTRWE YYAMTSFHYT IIVTEAIAYL RACLNPVLYA FVSLKFRKNF WKLVKDIGCL PYLGVSHQWK SSEDNSKTFS ASHNVEATSM FQL // ID BRB2_RABIT STANDARD; PRT; 367 AA. AC Q28642; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE B2 bradykinin receptor (BK-2 receptor) (B2R). GN BDKRB2. OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Lagomorpha; Leporidae; Oryctolagus. OX NCBI_TaxID=9986; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Liver; RX MEDLINE=96108663; PubMed=8531137; RA Bachvarov D.R., Saint-Jacques E., Larrivee J.F., Levesque L., RA Rioux F., Drapeau G., Marceau F.; RT "Cloning and pharmacological characterization of the rabbit RT bradykinin B2 receptor."; RL J. Pharmacol. Exp. Ther. 275:1623-1630(1995). CC -!- FUNCTION: Receptor for bradykinin. It is associated with G CC proteins that activate a phosphatidylinositol-calcium second CC messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U33334; AAA96149.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 36 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 37 60 1 (POTENTIAL). FT DOMAIN 61 69 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 70 94 2 (POTENTIAL). FT DOMAIN 95 107 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 108 129 3 (POTENTIAL). FT DOMAIN 130 151 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 152 174 4 (POTENTIAL). FT DOMAIN 175 197 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 198 224 5 (POTENTIAL). FT DOMAIN 225 243 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 244 268 6 (POTENTIAL). FT DOMAIN 269 287 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 288 311 7 (POTENTIAL). FT DOMAIN 312 367 CYTOPLASMIC (POTENTIAL). FT DISULFID 106 187 BY SIMILARITY. FT LIPID 327 327 S-palmitoyl cysteine (Potential). FT CARBOHYD 3 3 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 14 14 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 183 183 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 367 AA; 41480 MW; EF12A2A3A6FD9FC8 CRC64; MLNITSQVLA PALNGSVSQS SGCPNTEWSG WLNVIQAPFL WVLFVLATLE NLFVLSVFCL HKSSCTVAEV YLGNLAAADL ILACGLPFWA VTIANHFDWL FGEALCRVVN TMIYMNLYSS ICFLMLVSID RYLALVKTMS IGRMRRVRWA KLYSLVIWGC TLLLSSPMLV FRTMKDYRDE GYNVTACIID YPSRSWEVFT NVLLNLVGFL LPLSVITFCT VQILQVLRNN EMQKFKEIQT ERRATVLVLA VLLLFVVCWL PFQVSTFLDT LLKLGVLSSC WDEHVIDVIT QVGSFMGYSN SCLNPLVYVI VGKRFRKKSR EVYRAACPKA GCVLEPVQAE SSMGTLRTSI SVERQIHKLP EWTRSSQ // ID CCR5_MOUSE STANDARD; PRT; 374 AA. AC Q04683; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt'S lymphoma DE receptor 1 homolog). GN BLR1 OR CXCR5 OR GPCR6. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BALB/c; TISSUE=Liver; RX MEDLINE=94009211; PubMed=8405054; RA Kaiser E., Foerster R., Wolf I., Epensperger C., Kuehl W.M., Lipp M.; RT "The G protein-coupled receptor BLR1 is involved in murine B cell RT differentiation and is also expressed in neuronal tissues."; RL Eur. J. Immunol. 23:2532-2539(1993). RN [2] RP SEQUENCE OF 151-269 FROM N.A. RC TISSUE=Testis; RX MEDLINE=94116980; PubMed=8288218; RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., RA Copeland N.G., Jenkins N.A.; RT "Identification, chromosomal location, and genome organization of RT mammalian G-protein-coupled receptors."; RL Genomics 18:175-184(1993). RN [3] RP CHARACTERIZATION. RX MEDLINE=97133211; PubMed=8978608; RA Foerster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M.; RT "A putative chemokine receptor, BLR1, directs B cell migration to RT defined lymphoid organs and specific anatomic compartments of the RT spleen."; RL Cell 87:1037-1047(1996). RN [4] RP LIGAND BINDING. RX MEDLINE=98146056; PubMed=9486651; RA Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., RA Williams L.T.; RT "A B-cell-homing chemokine made in lymphoid follicles activates RT Burkitt's lymphoma receptor-1."; RL Nature 391:799-803(1998). CC -!- FUNCTION: Cytokine receptor that binds to B lymphocyte CC chemoattractant (BLC). Involved in B-cell migration into B-cell CC follicles of spleen and Peyer's patches, but not in those of CC mesentric or peripheral lymph nodes. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Mainly in spleen, in resting B-cells. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X71788; CAA50673.1; -. DR EMBL; L20332; AAA16852.1; -. DR PIR; S42628; S42628. DR MGD; MGI:103567; Blr1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00564; CXCCHMKINER5. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW B-cell activation; G-protein coupled receptor; Transmembrane; KW Glycoprotein. FT DOMAIN 1 57 Extracellular (Potential). FT TRANSMEM 58 78 1 (Potential). FT DOMAIN 79 90 Cytoplasmic (Potential). FT TRANSMEM 91 111 2 (Potential). FT DOMAIN 112 126 Extracellular (Potential). FT TRANSMEM 127 147 3 (Potential). FT DOMAIN 148 169 Cytoplasmic (Potential). FT TRANSMEM 170 190 4 (Potential). FT DOMAIN 191 221 Extracellular (Potential). FT TRANSMEM 222 242 5 (Potential). FT DOMAIN 243 261 Cytoplasmic (Potential). FT TRANSMEM 262 282 6 (Potential). FT DOMAIN 283 306 Extracellular (Potential). FT TRANSMEM 307 327 7 (Potential). FT DOMAIN 328 374 Cytoplasmic (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT CARBOHYD 198 198 N-linked (GlcNAc...) (Potential). FT DISULFID 124 204 Potential. SQ SEQUENCE 374 AA; 42100 MW; 385258420C1EDE30 CRC64; MNYPLTLDMG SITYNMDDLY KELAFYSNST EIPLQDSNFC STVEGPLLTS FKAVFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LVACIAVDRY LAIVHAVHAY RRRRLLSIHI TCTAIWLAGF LFALPELLFA KVGQPHNNDS LPQCTFSQEN EAETRAWFTS RFLYHIGGFL LPMLVMGWCY VGVVHRLLQA QRRPQRQKAV RVAILVTSIF FLCWSPYHIV IFLDTLERLK AVNSSCELSG YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPNWRKS SLSESENATS LTTF // ID CCR5_HUMAN STANDARD; PRT; 372 AA. AC P32302; Q14811; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt'S lymphoma DE receptor 1) (Monocyte-derived receptor 15) (MDR15). GN BLR1 OR CXCR5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM LONG). RC TISSUE=Lymphocytes; RX MEDLINE=93049615; PubMed=1425907; RA Dobner T., Wolf I., Emrich T., Lipp M.; RT "Differentiation-specific expression of a novel G protein-coupled RT receptor from Burkitt's lymphoma."; RL Eur. J. Immunol. 22:2795-2799(1992). RN [2] RP SEQUENCE FROM N.A. (ISOFORM SHORT). RC TISSUE=Blood; RX MEDLINE=95366951; PubMed=7639692; RA Barella L., Loetscher M., Tobler A., Baggiolini M., Moser B.; RT "Sequence variation of a novel heptahelical leucocyte receptor RT through alternative transcript formation."; RL Biochem. J. 309:773-779(1995). RN [3] RP LIGAND BINDING. RX MEDLINE=98130629; PubMed=9463416; RA Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., RA Baggiolini M., Moser B.; RT "B cell-attracting chemokine 1, a human CXC chemokine expressed in RT lymphoid tissues, selectively attracts B lymphocytes via RT BLR1/CXCR5."; RL J. Exp. Med. 187:655-660(1998). CC -!- FUNCTION: Cytokine receptor that binds to BLC. BLR1 exerts CC possibly a regulatory function in burkitt lymphoma (BL) CC lymphomagenesis and/or B-cell differentiation. It is a potential CC candidate for cell-cell interaction, and activation of mature B- CC lymphocytes in lymphatic tissues. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Long; CC IsoId=P32302-1; Sequence=Displayed; CC Name=Short; CC IsoId=P32302-2; Sequence=VSP_001892; CC -!- TISSUE SPECIFICITY: Expression in mature B-cells and Burkitt CC lymphoma cells. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X68149; CAA48252.1; -. DR EMBL; X68829; CAA48723.1; -. DR PIR; S26667; S26667. DR Genew; HGNC:1060; BLR1. DR MIM; 601613; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0006928; P:cell motility; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00564; CXCCHMKINER5. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW B-cell activation; G-protein coupled receptor; Transmembrane; KW Glycoprotein; Alternative splicing; Polymorphism. FT DOMAIN 1 55 Extracellular (Potential). FT TRANSMEM 56 76 1 (Potential). FT DOMAIN 77 88 Cytoplasmic (Potential). FT TRANSMEM 89 109 2 (Potential). FT DOMAIN 110 124 Extracellular (Potential). FT TRANSMEM 125 145 3 (Potential). FT DOMAIN 146 167 Cytoplasmic (Potential). FT TRANSMEM 168 188 4 (Potential). FT DOMAIN 189 219 Extracellular (Potential). FT TRANSMEM 220 240 5 (Potential). FT DOMAIN 241 259 Cytoplasmic (Potential). FT TRANSMEM 260 280 6 (Potential). FT DOMAIN 281 304 Extracellular (Potential). FT TRANSMEM 305 325 7 (Potential). FT DOMAIN 326 372 Cytoplasmic (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT CARBOHYD 196 196 N-linked (GlcNAc...) (Potential). FT DISULFID 122 202 Potential. FT VARSPLIC 1 45 Missing (in isoform Short). FT /FTId=VSP_001892. FT VARIANT 344 344 G -> S (in dbSNP:665648). FT /FTId=VAR_011838. SQ SEQUENCE 372 AA; 41955 MW; 6DF84C839492ACCF CRC64; MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL SESENATSLT TF // ID AG22_HUMAN STANDARD; PRT; 363 AA. AC P50052; Q13016; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Type-2 angiotensin II receptor (AT2). GN AGTR2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Liver; RX MEDLINE=95251653; PubMed=7733925; RA Martin M.M., Elton T.S.; RT "The sequence and genomic organization of the human type 2 RT angiotensin II receptor."; RL Biochem. Biophys. Res. Commun. 209:554-562(1995). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RX MEDLINE=95309939; PubMed=7790004; RA Chassagne C., Beatty B.G., Meloche S.; RT "Assignment of the human angiotensin II type 2 receptor gene (AGTR2) RT to chromosome Xq22-q23 by fluorescence in situ hybridization."; RL Genomics 25:601-603(1995). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Blood; RX MEDLINE=95032069; PubMed=7945336; RA Koike G., Horiuchi M., Yamada T., Szpirer C., Jacob H.J., Dzau V.J.; RT "Human type 2 angiotensin II receptor gene: cloned, mapped to the X RT chromosome, and its mRNA is expressed in the human lung."; RL Biochem. Biophys. Res. Commun. 203:1842-1850(1994). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RX MEDLINE=94242007; PubMed=8185599; RA Tsuzuki S., Ichiki T., Nakakubo H., Kitami Y., Guo D.F., RA Shirai H., Inagami T.; RT "Molecular cloning and expression of the gene encoding human RT angiotensin II type 2 receptor."; RL Biochem. Biophys. Res. Commun. 200:1449-1454(1994). RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=95091796; PubMed=7999093; RA Martin M.M., Su B., Elton T.S.; RT "Molecular cloning of the human angiotensin II type 2 receptor cDNA."; RL Biochem. Biophys. Res. Commun. 205:645-651(1994). RN [6] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RX MEDLINE=95236034; PubMed=7719706; RA Lazard D., Briend-Sutren M.M., Villageois P., Mattei M.-G., RA Strosberg A.D., Nahmias C.; RT "Molecular characterization and chromosome localization of a human RT angiotensin II AT2 receptor gene highly expressed in fetal tissues."; RL Recept. Channels 2:271-280(1994). RN [7] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [8] RP SEQUENCE OF 1-22 FROM N.A. RC TISSUE=Blood; RA Katsuya T., Dzau V.J.; RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases. RN [9] RP SEQUENCE OF 1-16 FROM N.A. RC TISSUE=Uterus; RA Warnecke C.H., Holzmeister J., Regitz-Zagrosek V., Fleck E.; RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for angiotensin II. May have a role in cell CC morphogenesis and related events in growth and development. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: In adult, highly expressed in myometrium with CC lower levels in adrenal gland and fallopian tube. Very highly CC expressed in fetal kidney and intestine. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U20860; AAA85851.1; -. DR EMBL; L34579; AAA98990.1; -. DR EMBL; U10273; AAA61794.1; -. DR EMBL; U15592; AAA50762.1; -. DR EMBL; U16957; AAA67753.1; -. DR EMBL; AY322542; AAP84355.1; -. DR EMBL; U27478; AAA84900.1; -. DR EMBL; X87723; CAA61022.1; -. DR PIR; JC2543; JC2543. DR HSSP; P34996; 1DDD. DR Genew; HGNC:338; AGTR2. DR MIM; 300034; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004945; F:angiotensin type II receptor activity; TAS. DR GO; GO:0004860; F:protein kinase inhibitor activity; TAS. DR GO; GO:0006915; P:apoptosis; TAS. DR GO; GO:0007610; P:behavior; TAS. DR GO; GO:0007166; P:cell surface receptor linked signal transdu...; TAS. DR GO; GO:0008217; P:regulation of blood pressure; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00636; ANGIOTENSN2R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Polymorphism. FT DOMAIN 1 45 Extracellular (Potential). FT TRANSMEM 46 71 1 (Potential). FT DOMAIN 72 80 Cytoplasmic (Potential). FT TRANSMEM 81 102 2 (Potential). FT DOMAIN 103 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT DOMAIN 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 179 4 (Potential). FT DOMAIN 180 208 Extracellular (Potential). FT TRANSMEM 209 234 5 (Potential). FT DOMAIN 235 256 Cytoplasmic (Potential). FT TRANSMEM 257 278 6 (Potential). FT DOMAIN 279 285 Extracellular (Potential). FT TRANSMEM 286 313 7 (Potential). FT DOMAIN 314 363 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential). FT VARIANT 248 248 R -> K (in dbSNP:5191). FT /FTId=VAR_011849. FT VARIANT 268 268 C -> W (in dbSNP:1042860). FT /FTId=VAR_011850. FT CONFLICT 269 269 W -> C (in Ref. 5). FT CONFLICT 272 272 F -> L (in Ref. 4). FT CONFLICT 323 323 N -> G (in Ref. 4). SQ SEQUENCE 363 AA; 41183 MW; FDD7D4E6F9B43E60 CRC64; MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL YYIIFVIGFL VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR KSSSLREMET FVS // ID GALS_RAT STANDARD; PRT; 372 AA. AC O08726; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Galanin receptor type 2 (GAL2-R) (GALR2). GN GALR2 OR GALNR2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Hypothalamus; RX MEDLINE=97261892; PubMed=9108306; RA Howard A.D., Tan C., Shiao L.L., Palyha O.C., McKee K.K., RA Weinberg D.H., Feighner S.D., Cascieri M.A., Smith R.G., RA van der Ploeg L.H.T., Sullivan K.A.; RT "Molecular cloning and characterization of a new receptor for RT galanin."; RL FEBS Lett. 405:285-290(1997). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=97450996; PubMed=9305929; RA Smith K.E., Forray C., Walker M.W., Jones K.A., Tamm J.A., Bard J., RA Branchek T.A., Linemeyer D.L., Gerald C.; RT "Expression cloning of a rat hypothalamic galanin receptor coupled to RT phosphoinositide turnover."; RL J. Biol. Chem. 272:24612-24616(1997). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Hypothalamus; RX MEDLINE=97428353; PubMed=9281594; RA Wang S., Hashemi T., He C., Strader C., Bayne M.; RT "Molecular cloning and pharmacological characterization of a new RT galanin receptor subtype."; RL Mol. Pharmacol. 52:337-343(1997). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=98087378; PubMed=9427506; RA Fathi Z., Cunningham A.M., Iben L.G., Battaglino P.B., Ward S.A., RA Nichol K.A., Pine K.A., Wang J., Goldstein M.E., Iismaa T.P., RA Zimanyi I.A.; RT "Cloning, pharmacological characterization and distribution of a novel RT galanin receptor."; RL Brain Res. Mol. Brain Res. 51:49-59(1997). RN [5] RP ERRATUM. RA Fathi Z., Cunningham A.M., Iben L.G., Battaglino P.B., Ward S.A., RA Nichol K.A., Pine K.A., Wang J., Goldstein M.E., Iismaa T.P., RA Zimanyi I.A.; RL Brain Res. Mol. Brain Res. 53:348-348(1998). CC -!- FUNCTION: RECEPTOR FOR THE HORMONE GALANIN AND FOR GALP. THE CC ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G PROTEINS THAT ACTIVATE CC THE PHOSPHOLIPASE C/PROTEIN KINASE C PATHWAY (VIA GQ) AND THAT CC INHIBIT ADENYLYL CYCLASE (VIA GI). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U94322; AAB53220.1; -. DR EMBL; AF010318; AAC53358.1; -. DR EMBL; Y15248; CAA75532.1; -. DR EMBL; AF008548; AAB62573.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 49 1 (POTENTIAL). FT DOMAIN 50 60 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 61 81 2 (POTENTIAL). FT DOMAIN 82 99 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 100 121 3 (POTENTIAL). FT DOMAIN 122 141 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 142 162 4 (POTENTIAL). FT DOMAIN 163 187 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 188 208 5 (POTENTIAL). FT DOMAIN 209 237 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 238 258 6 (POTENTIAL). FT DOMAIN 259 260 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 261 281 7 (POTENTIAL). FT DOMAIN 282 372 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 11 11 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 98 175 BY SIMILARITY. SQ SEQUENCE 372 AA; 40675 MW; 5E7B67B35A54AB6E CRC64; MNGSGSQGAE NTSQEGGSGG WQPEAVLVPL FFALIFLVGT VGNALVLAVL LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDD WVFGSLLCKA VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW GLALLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDLC TFVFSYLLPV LVLSLTYART LRYLWRTVDP VTAGSGSQRA KRKVTRMIII VAVLFCLCWM PHHALILCVW FGRFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR KGFRKICAGL LRPAPRRASG RVSILAPGNH SGSMLEQEST DLTQVSEAAG PLVPPPALPN CTASSRTLDP AC // ID AG22_RAT STANDARD; PRT; 363 AA. AC P35351; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Type-2 angiotensin II receptor (AT2). GN AGTR2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94043303; PubMed=8227011; RA Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H., RA Hamakubo T., Inagami T.; RT "Molecular cloning of a novel angiotensin II receptor isoform RT involved in phosphotyrosine phosphatase inhibition."; RL J. Biol. Chem. 268:24543-24546(1993). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Fetal; RX MEDLINE=94043302; PubMed=8227010; RA Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E., RA Dzau V.J.; RT "Expression cloning of type 2 angiotensin II receptor reveals a RT unique class of seven-transmembrane receptors."; RL J. Biol. Chem. 268:24539-24542(1993). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=Fischer; TISSUE=Liver; RX MEDLINE=96088876; PubMed=7490161; RA Koike G., Winer E.S., Horiuchi M., Brown D.M., Szpirer C., RA Dzau V.J., Jacob H.J.; RT "Cloning, characterization, and genetic mapping of the rat type 2 RT angiotensin II receptor gene."; RL Hypertension 26:998-1002(1995). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=95228708; PubMed=7713098; RA Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S., RA Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K., RA Ichiki T.; RT "Cloning, expression and regulation of angiotensin II receptors."; RL Eur. Heart J. 15:104-107(1994). RN [5] RP SEQUENCE OF 1-143 FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=95322457; PubMed=7599191; RA Kobayashi S., Ohnishi J., Nibu Y., Nishimatsu S., Umemura S., RA Ishii M., Murakami K., Miyazaki H.; RT "Cloning of the rat angiotensin II type 2 receptor gene and RT identification of its functional promoter region."; RL Biochim. Biophys. Acta 1262:155-158(1995). CC -!- FUNCTION: Receptor for angiotensin II. May have a role in cell CC morphogenesis and related events in growth and development. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Abundant expression in fetal tissues, immature CC brain, skin wound and atretic ovarian follicles. CC -!- DEVELOPMENTAL STAGE: Abundant in whole fetus but decreases rapidly CC after birth. In adults is highly expressed in the adrenal, present CC in the brain and uterus but undetectable in the heart. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D16840; BAA04116.1; -. DR EMBL; U01908; AAC52126.1; -. DR EMBL; U22663; AAA86509.1; -. DR EMBL; D43778; BAA07833.1; -. DR PIR; A49092; A49092. DR HSSP; P34996; 1DDD. DR RGD; 2072; Agtr2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00636; ANGIOTENSN2R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation. FT DOMAIN 1 45 Extracellular (Potential). FT TRANSMEM 46 71 1 (Potential). FT DOMAIN 72 80 Cytoplasmic (Potential). FT TRANSMEM 81 102 2 (Potential). FT DOMAIN 103 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT DOMAIN 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 179 4 (Potential). FT DOMAIN 180 208 Extracellular (Potential). FT TRANSMEM 209 234 5 (Potential). FT DOMAIN 235 256 Cytoplasmic (Potential). FT TRANSMEM 257 278 6 (Potential). FT DOMAIN 279 285 Extracellular (Potential). FT TRANSMEM 286 313 7 (Potential). FT DOMAIN 314 363 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential). FT MOD_RES 354 354 Phosphoserine (by PKC) (Potential). SQ SEQUENCE 363 AA; 41331 MW; 4FE4551A41336650 CRC64; MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR KSSSLREMDT FVS // ID FML1_PANTR STANDARD; PRT; 348 AA. AC P79242; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE FMLP-related receptor I (FMLP-R-I) (Fragment). GN FPRL1. OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=96421539; PubMed=8824156; RA Alvarez V., Coto E., Sehen F., Gouzalek-Koces S., Lopez-Larrea C.; RT "Molecular evolution of the N-formyl peptide and C5a receptors in RT non-human primates."; RL Immunogenetics 44:446-452(1996). CC -!- FUNCTION: LOW AFFINITY RECEPTOR TO N-FORMYL-METHIONYL PEPTIDES, CC WHICH ARE POWERFUL NEUTROPHILS CHEMOTACTIC FACTORS. BINDING OF CC FMLP TO THE RECEPTOR CAUSES ACTIVATION OF NEUTROPHILS. THIS CC RESPONSE IS MEDIATED VIA A G-PROTEIN THAT ACTIVATES A CC PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X97739; CAA66323.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Chemotaxis. FT NON_TER 1 1 FT DOMAIN <1 24 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 25 47 1 (POTENTIAL). FT DOMAIN 48 58 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 59 80 2 (POTENTIAL). FT DOMAIN 81 97 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 98 118 3 (POTENTIAL). FT DOMAIN 119 137 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 138 159 4 (POTENTIAL). FT DOMAIN 160 202 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 203 223 5 (POTENTIAL). FT DOMAIN 224 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 263 6 (POTENTIAL). FT DOMAIN 264 283 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 284 303 7 (POTENTIAL). FT DOMAIN 304 348 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 1 1 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 95 173 POTENTIAL. FT NON_TER 348 348 SQ SEQUENCE 348 AA; 38574 MW; 55B76670DF4D594E CRC64; NFSTPLNEYE EGSYESAGYT VLRILPLVVL GVTFVLGVLG NGLVIWVAGF RMTRTVTTIC YLNLALADFS FTATLPFLIV SMAMGEKWPF GWFLCKLIHI VVDINLFGSV FLIGFIALDR CICVLHPVWA QNHRTVSLAM KVIVGPWILA LVLTLPVFLF LTTVTIPNGD TYCTFNFASW GGTPEERLKV AITLLTARGI IRFVIGFSLP MSIVAICYGL IAAKIHKKGM IKSSRPLRVL TAVVASFFIC WFPFQLVALL GTVWLKEMLF YGKYKIIDIL VNPTSSLAFF NCCLNPMLYV FVGQDFRERL IHSLPTSLER ALSEDSAPTN DTAANCASPP AETELQAM // ID FML1_MACMU STANDARD; PRT; 348 AA. AC P79190; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE FMLP-related receptor I (FMLP-R-I) (Fragment). GN FPRL1. OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=96421539; PubMed=8824156; RA Alvarez V., Coto E., Sehen F., Gouzalek-Koces S., Lopez-Larrea C.; RT "Molecular evolution of the N-formyl peptide and C5a receptors in RT non-human primates."; RL Immunogenetics 44:446-452(1996). CC -!- FUNCTION: LOW AFFINITY RECEPTOR TO N-FORMYL-METHIONYL PEPTIDES, CC WHICH ARE POWERFUL NEUTROPHILS CHEMOTACTIC FACTORS. BINDING OF CC FMLP TO THE RECEPTOR CAUSES ACTIVATION OF NEUTROPHILS. THIS CC RESPONSE IS MEDIATED VIA A G-PROTEIN THAT ACTIVATES A CC PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X97737; CAA66321.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Chemotaxis. FT NON_TER 1 1 FT DOMAIN <1 24 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 25 47 1 (POTENTIAL). FT DOMAIN 48 58 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 59 80 2 (POTENTIAL). FT DOMAIN 81 97 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 98 118 3 (POTENTIAL). FT DOMAIN 119 137 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 138 159 4 (POTENTIAL). FT DOMAIN 160 202 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 203 223 5 (POTENTIAL). FT DOMAIN 224 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 263 6 (POTENTIAL). FT DOMAIN 264 283 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 284 303 7 (POTENTIAL). FT DOMAIN 304 348 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 1 1 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 95 173 POTENTIAL. FT NON_TER 348 348 SQ SEQUENCE 348 AA; 38456 MW; BC185DFAC14B694E CRC64; NFSTPLSEYE EVSYESAGYT VLQILPLVVL GVTFVLGVLG NGLVIWVAGF RMTRTVTTIC YLNLALADFS FTATLPFLIV SMAMGEKWPF GWFLCKLIHI VVDINLFGSV FLIGFIALDR CICVLHPVWA QNHRTVSLAM KVIVGPWILA LVLTLPVFLF LTTVTIPNGD TYCTFNFASW GGTPEKRLKV AITMLTARGI IRFVIGFSMP MSIVATCYGL IAAKIHKKGM IKSSRPLRVL TAVVASFFIC WFPFQLVALL STVWLKEILV DGKYKIINIL VNPTSSLAFF NSCLNPMLYV FVGQDFRERL IHSLPTSLER ALSEDSAPTN DTAASCASPP AETELQAM // ID FMLR_RABIT STANDARD; PRT; 352 AA. AC Q05394; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) DE (FPR) (N-formylpeptide chemoattractant receptor). GN FPR1. OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Lagomorpha; Leporidae; Oryctolagus. OX NCBI_TaxID=9986; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=New Zealand white; TISSUE=Neutrophils; RX MEDLINE=93163563; PubMed=8432984; RA Ye R.D., Quehenberger O., Thomas K.M., Navarro J., Cavanagh S.L., RA Prossnitz E.R., Cochrane C.G.; RT "The rabbit neutrophil N-formyl peptide receptor. cDNA cloning, RT expression, and structure/function implications."; RL J. Immunol. 150:1383-1394(1993). CC -!- FUNCTION: HIGH AFFINITY RECEPTOR FOR N-FORMYL-METHIONYL PEPTIDES, CC WHICH ARE POWERFUL NEUTROPHILS CHEMOTACTIC FACTORS. BINDING OF CC FMLP TO THE RECEPTOR CAUSES ACTIVATION OF NEUTROPHILS. THIS CC RESPONSE IS MEDIATED VIA A G-PROTEIN THAT ACTIVATES A CC PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: NEUTROPHILS. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M94549; AAA31254.1; -. DR PIR; A46520; A46520. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Chemotaxis. FT DOMAIN 1 27 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 28 50 1 (POTENTIAL). FT DOMAIN 51 61 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 62 83 2 (POTENTIAL). FT DOMAIN 84 100 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 101 121 3 (POTENTIAL). FT DOMAIN 122 140 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 141 162 4 (POTENTIAL). FT DOMAIN 163 207 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 208 228 5 (POTENTIAL). FT DOMAIN 229 244 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 245 268 6 (POTENTIAL). FT DOMAIN 269 287 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 288 307 7 (POTENTIAL). FT DOMAIN 308 352 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 10 10 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 98 178 POTENTIAL. SQ SEQUENCE 352 AA; 38674 MW; 51DA550DAB13A091 CRC64; MDSNASLPLN VSGGTQATPA GLVVLDVFSY LILVVTFVLG VLGNGLVIWV TGFRMTHTVT TISYLNLALA DFSFTSTLPF FIVTKALGGH WPFGWFLCKF VFTIVDINLF GSVFLIALIA LDRCICVLHP VWAQNHRNVS LAKKVIVGPW ICALLLTLPV IIRVTTLSHP RAPGKMACTF DWSPWTEDPA EKLKVAISMF MVRGIIRFII GFSTPMSIVA VCYGLIATKI HRQGLIKSSR PLRVLSFVVA SFLLCWSPYQ IAALIATVRI RELLLGMGKD LRIVLDVTSF VAFFNSCLNP MLYVFMGQDF RERLIHSLPA SLERALSEDS AQTSDTGTNS TSAPAEAELQ AI // ID CML1_MOUSE STANDARD; PRT; 371 AA. AC P97468; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Chemokine receptor-like 1 (G-protein coupled receptor DEZ). GN CMKLR1 OR DEZ OR GPCR27. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=97289630; PubMed=9144535; RA Methner A., Hermey G., Schinke B., Hermans-Borgmeyer I.; RT "A novel G protein-coupled receptor with homology to neuropeptide and RT chemoattractant receptors expressed during bone development."; RL Biochem. Biophys. Res. Commun. 233:336-342(1997). CC -!- FUNCTION: Orphan receptor. Could be a chemotactic peptide CC receptor. May have a function in bone metabolism. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- DEVELOPMENTAL STAGE: Expressed during bone development and in CC adult parathyroid glands. Expressed at day E11 in the caudal part CC of the tongue and the umbilical cord and the expression in the CC tongue was maintained throughout adulthood. Expression increases CC in bone and cartilaginous forming zones of embryo up to stage CC E14.5 and at E16.5 expression is seen in the lung. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U79525; AAB53789.1; -. DR PIR; JC5498; JC5498. DR MGD; MGI:109603; Cmklr1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 39 Extracellular (Potential). FT TRANSMEM 40 62 1 (Potential). FT DOMAIN 63 73 Cytoplasmic (Potential). FT TRANSMEM 74 95 2 (Potential). FT DOMAIN 96 112 Extracellular (Potential). FT TRANSMEM 113 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic (Potential). FT TRANSMEM 153 174 4 (Potential). FT DOMAIN 175 222 Extracellular (Potential). FT TRANSMEM 223 243 5 (Potential). FT DOMAIN 244 259 Cytoplasmic (Potential). FT TRANSMEM 260 280 6 (Potential). FT DOMAIN 281 298 Extracellular (Potential). FT TRANSMEM 299 318 7 (Potential). FT DOMAIN 319 371 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 190 190 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 Potential. SQ SEQUENCE 371 AA; 41815 MW; CDBE19305244C0B3 CRC64; MEYDAYNDSG IYDDEYSDGF GYFVDLEEAS PWEAKVAPVF LVVIYSLVCF LGLLGNGLVI VIATFKMKKT VNTVWFVNLA VADFLFNIFL PMHITYAAMD YHWVFGKAMC KISNFLLSHN MYTSVFLLTV ISFDRCISVL LPVWSQNHRS IRLAYMTCSA VWVLAFFLSS PSLVFRDTAN IHGKITCFNN FSLAAPESSP HPAHSQVVST GYSRHVAVTV TRFLCGFLIP VFIITACYLT IVFKLQRNRL AKNKKPFKII ITIIITFFLC WCPYHTLYLL ELHHTAVPSS VFSLGLPLAT AVAIANSCMN PILYVFMGHD FRKFKVALFS RLANALSEDT GPSSYPSHRS FTKMSSLNEK ASVNEKETST L // ID NK1R_RANCA STANDARD; PRT; 408 AA. AC Q98982; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin DE receptor 1). GN TACR1 OR TAC1R. OS Rana catesbeiana (Bull frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana. OX NCBI_TaxID=8400; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Sympathetic ganglion; RX MEDLINE=97363687; PubMed=9219980; RA Simmons M.A., Brodbeck R.M., Karpitskiy V.V., Schneider C.R., RA Neff D.P.A., Krause J.E.; RT "Molecular characterization and functional expression of a substance RT P receptor from the sympathetic ganglion of Rana catesbeiana."; RL Neuroscience 79:1219-1229(1997). CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide CC substance P. It is probably associated with G proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to other tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U67736; AAC05707.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01024; NEUROKININ1R. DR PRINTS; PR00244; NEUROKININR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 32 Extracellular (Potential). FT TRANSMEM 33 55 1 (Potential). FT DOMAIN 56 65 Cytoplasmic (Potential). FT TRANSMEM 66 87 2 (Potential). FT DOMAIN 88 107 Extracellular (Potential). FT TRANSMEM 108 129 3 (Potential). FT DOMAIN 130 149 Cytoplasmic (Potential). FT TRANSMEM 150 170 4 (Potential). FT DOMAIN 171 196 Extracellular (Potential). FT TRANSMEM 197 221 5 (Potential). FT DOMAIN 222 250 Cytoplasmic (Potential). FT TRANSMEM 251 272 6 (Potential). FT DOMAIN 273 283 Extracellular (Potential). FT TRANSMEM 284 308 7 (Potential). FT DOMAIN 309 408 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT DISULFID 106 181 By similarity. FT LIPID 323 323 S-palmitoyl cysteine (Potential). SQ SEQUENCE 408 AA; 47010 MW; 300C28AE8820640E CRC64; MNSNISAQND SALNSTIQNG TKINQFIQPP WQIALWSVAY SIIVIVSLVG NIIVMWIIIA HKRMRTVTNY FLVNLAFAEA SMSAFNTVIN FTYAIHNHWY YGLIYCKFHN FFPISAVFTS IYSMTAIALD RYMAIIHPLK PRLSATATKI VICVIWSFSF CMAFPLGYYA DVYPMEGGDI CYLNWPDSEE NRKYEQVYQV LVFCLIYILP LLVIGCAYTF IGMTLWASEI PGDSSDRYHE QVVAKRKVVK MMIVVVCTFA ICWLPFHIFF LLQTLHEMTQ KFYQQFYLAI MWLAMSSTMY NPIIYCCLND RFRIGFKHVF RWCPFIRAGE YEGLELKSTR YLQTQSSMYK ISRIETTVSS VLNTNDEEAE ENGKSSKRLS LDLTSNGSSR SVCKTMSDSS SFYSNNLA // ID R3R2_HUMAN STANDARD; PRT; 374 AA. AC Q8TDU9; Q8NGZ8; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Relaxin 3 receptor 2 (G protein-coupled receptor 100) (GPCR142). GN GPR100. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A., AND FUNCTION. RX PubMed=14522967; RA Liu C., Chen J., Sutton S., Roland B., Kuei C., Farmer N., Sillard R., RA Lovenberg T.W.; RT "Identification of relaxin-3/INSL7 as a ligand for GPCR142."; RL J. Biol. Chem. 278:50765-50770(2003). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=22985413; PubMed=14623098; RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., RA Schioeth H.B.; RT "Seven evolutionarily conserved human rhodopsin G protein-coupled RT receptors lacking close relatives."; RL FEBS Lett. 554:381-388(2003). RN [3] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=22040266; PubMed=12044878; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). CC -!- FUNCTION: Receptor for relaxin-3. Binding of the ligand inhibit CC cAMP accumulation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in a broader range of tissues CC including brain, kidney, testis, thymus, placenta, prostate, CC salivary gland, thyroid and colon. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- CAUTION: Ref.3 sequence differs from that shown due to erroneous CC gene model prediction. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY394502; AAQ92316.1; -. DR EMBL; AY288415; AAP72124.1; -. DR EMBL; AB065617; BAC05844.1; ALT_SEQ. DR EMBL; AB083593; BAB89306.1; -. DR Genew; HGNC:14666; GPR100. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 43 Extracellular (Potential). FT TRANSMEM 44 64 1 (Potential). FT DOMAIN 65 78 Cytoplasmic (Potential). FT TRANSMEM 79 99 2 (Potential). FT DOMAIN 100 116 Extracellular (Potential). FT TRANSMEM 117 137 3 (Potential). FT DOMAIN 138 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 4 (Potential). FT DOMAIN 176 209 Extracellular (Potential). FT TRANSMEM 210 230 5 (Potential). FT DOMAIN 231 249 Cytoplasmic (Potential). FT TRANSMEM 250 270 6 (Potential). FT DOMAIN 271 281 Extracellular (Potential). FT TRANSMEM 282 302 7 (Potential). FT DOMAIN 303 374 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 114 191 By similarity. FT CONFLICT 329 329 L -> S (in Ref. 1). SQ SEQUENCE 374 AA; 41141 MW; 1929EA812C0804DA CRC64; MPTLNTSASP PTFFWANASG GSVLSADDAP MPVKFLALRL MVALAYGLVG AIGLLGNLAV LWVLSNCARR APGPPSDTFV FNLALADLGL ALTLPFWAAE SALDFHWPFG GALCKMVLTA TVLNVYASIF LITALSVARY WVVAMAAGPG THLSLFWARI ATLAVWAAAA LVTVPTAVFG VEGEVCGVRL CLLRFPSRYW LGAYQLQRVV LAFMVPLGVI TTSYLLLLAF LQRRQRRRQD SRVVARSVRI LVASFFLCWF PNHVVTLWGV LVKFDLVPWN STFYTIQTYV FPVTTCLAHS NSCLNPVLYC LLRREPRQAL AGTFRDLRLR LWPQGGGWVQ QVALKQVGRR WVASNPRESR PSTLLTNLDR GTPG // ID NY1R_MOUSE STANDARD; PRT; 382 AA. AC Q04573; Q61993; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Neuropeptide Y receptor type 1 (NPY1-R). GN NPY1R. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Liver; RX MEDLINE=93106169; PubMed=1468559; RA Eva C., Oberto A., Sprengel R., Genazzani E.; RT "The murine NPY-1 receptor gene. Structure and delineation of tissue- RT specific expression."; RL FEBS Lett. 314:285-288(1992). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=96102072; PubMed=8530415; RA Nakamura M., Sakanaka C., Aoki Y., Ogasawara H., Tsuji T., RA Kodama H., Matsumoto T., Shimizu T., Noma M.; RT "Identification of two isoforms of mouse neuropeptide Y-Y1 receptor RT generated by alternative splicing. Isolation, genomic structure, and RT functional expression of the receptors."; RL J. Biol. Chem. 270:30102-30110(1995). CC -!- FUNCTION: RECEPTOR FOR NEUROPEPTIDE Y AND PEPTIDE YY. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=NPY1-R alpha; CC IsoId=Q04573-1; Sequence=Displayed; CC Name=NPY1-R beta; CC IsoId=Q04573-2; Sequence=VSP_001912, VSP_001913; CC -!- TISSUE SPECIFICITY: THE ALPHA FORM IS HIGHLY EXPRESSED IN THE CC BRAIN, HEART, KIDNEY, SPLEEN, SKELETAL MUSCLE, AND LUNG, WHEREAS CC THE BETA RECEPTOR MRNA WAS NOT DETECTED IN THESE TISSUES. HOWEVER, CC THE BETA FORM IS EXPRESSED IN MOUSE EMBRYONIC DEVELOPMENTAL STAGE CC (7 AND 11 DAYS), BONE MARROW CELLS AND SEVERAL HEMATOPOIETIC CELL CC LINES. CC -!- DEVELOPMENTAL STAGE: THE BETA FORM IS EXPRESSED IN EMBRYONIC CC DEVELOPMENTAL STAGE (7 AND 11 DAYS). THE BETA FORM IS AN EMBRYONIC CC AND A BONE MARROW FORM OF NPY1-R, WHICH DECREASES IN THE CC EXPRESSION DURING DEVELOPMENT AND DIFFERENTIATION. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Z18280; CAA79157.1; -. DR EMBL; Z18281; -; NOT_ANNOTATED_CDS. DR EMBL; D63818; BAA09887.1; -. DR EMBL; D63819; BAA09888.1; -. DR PIR; S27388; S27388. DR MGD; MGI:104963; Npy1r. DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IDA. DR GO; GO:0001601; F:peptide YY receptor activity; IDA. DR GO; GO:0007631; P:feeding behavior; IMP. DR GO; GO:0006006; P:glucose metabolism; IMP. DR GO; GO:0007626; P:locomotory behavior; IMP. DR GO; GO:0019233; P:perception of pain; IMP. DR GO; GO:0008217; P:regulation of blood pressure; IMP. DR GO; GO:0040014; P:regulation of body size; IMP. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate; Alternative splicing. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 61 1 (POTENTIAL). FT DOMAIN 62 71 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 72 93 2 (POTENTIAL). FT DOMAIN 94 113 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 114 135 3 (POTENTIAL). FT DOMAIN 136 155 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 156 176 4 (POTENTIAL). FT DOMAIN 177 209 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 210 231 5 (POTENTIAL). FT DOMAIN 232 262 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 263 285 6 (POTENTIAL). FT DOMAIN 286 298 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 299 322 7 (POTENTIAL). FT DOMAIN 323 382 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 11 11 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 17 17 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 112 197 BY SIMILARITY. FT LIPID 337 337 S-palmitoyl cysteine (By similarity). FT VARSPLIC 304 307 CHLT -> LNMN (in isoform NPY1-R beta). FT /FTId=VSP_001912. FT VARSPLIC 308 382 Missing (in isoform NPY1-R beta). FT /FTId=VSP_001913. SQ SEQUENCE 382 AA; 44014 MW; CDCCF93E3ABB4D70 CRC64; MNSTLFSKVE NHSIHYNASE NSPLLAFEND DCHLPLAVIF TLALAYGAVI ILGVSGNLAL IIIILKQKEM RNVTNILIVN LSFSDLLVAV MCLPFTFVYT LMDHWVFGET MCKLNPFVQC VSITVSIFSL VLIAVERHQL IINPRGWRPN NRHAYIGITV IWVLAVASSL PFVIYQILTD EPFQNVSLAA FKDKYVCFDK FPSDSHRLSY TTLLLVLQYF GPLCFIFICY FKIYIRLKRR NNMMDKIRDS KYRSSETKRI NIMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA MSTMHTDVSK TSLKQASPVA FKKISMNDNE KV // ID ETBR_HORSE STANDARD; PRT; 443 AA. AC O62709; O77508; DT 15-DEC-1998 (Rel. 37, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Endothelin B receptor precursor (ET-B) (Endothelin receptor DE Non-selective type). GN EDNRB. OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796; RN [1] RP SEQUENCE FROM N.A., AND VARIANT OLWS LYS-126. RC TISSUE=Liver; RX MEDLINE=98248431; PubMed=9580670; RA Yang G.C., Croaker D., Zhang A.L., Manglick P., Cartmill T., Cass D.; RT "A dinucleotide mutation in the endothelin-B receptor gene is RT associated with lethal white foal syndrome (LWFS); a horse variant of RT Hirschsprung disease."; RL Hum. Mol. Genet. 7:1047-1052(1998). RN [2] RP SEQUENCE OF 8-443 FROM N.A., AND VARIANT OLWS LYS-126. RX MEDLINE=98191732; PubMed=9530628; RA Santschi E.M., Purdy A.K., Valberg S.J., Vrotsos P.D., Kaese H., RA Mickelson J.R.; RT "Endothelin receptor B polymorphism associated with lethal white foal RT syndrome in horses."; RL Mamm. Genome 9:306-309(1998). CC -!- FUNCTION: NON-SPECIFIC RECEPTOR FOR ENDOTHELIN 1, 2, AND 3. CC MEDIATES ITS ACTION BY ASSOCIATION WITH G PROTEINS THAT ACTIVATE CC A PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- DISEASE: DEFECTS IN EDNRB ARE A CAUSE OF OVERO LETHAL WHITE CC SYNDROME (OLWS) ALSO KNOWN AS LETHAL WHITE FOAL SYNDROME (LWFS). CC IT IS AN INHERITED SYNDROME OF FOALS BORN TO AMERICAN PAINT HORSE CC PARENTS OF THE OVERO COAT-PATTERN LINEAGE. AFFECTED FOALS ARE CC TOTALLY OR ALMOST TOTALLY WHITE AND DIE WITHIN DAYS FROM CC COMPLICATIONS DUE TO INTESTINAL AGANGLIONOSIS. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF019072; AAC25983.1; -. DR EMBL; AF038900; AAC23486.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Lipoprotein; Palmitate; Disease mutation. FT SIGNAL 1 26 POTENTIAL. FT CHAIN 27 443 ENDOTHELIN B RECEPTOR. FT DOMAIN 27 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 127 1 (POTENTIAL). FT DOMAIN 128 138 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 139 164 2 (POTENTIAL). FT DOMAIN 165 176 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 177 198 3 (POTENTIAL). FT DOMAIN 199 219 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 220 244 4 (POTENTIAL). FT DOMAIN 245 272 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 273 297 5 (POTENTIAL). FT DOMAIN 298 325 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 326 351 6 (POTENTIAL). FT DOMAIN 352 363 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 364 390 7 (POTENTIAL). FT DOMAIN 391 443 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 60 60 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 175 256 BY SIMILARITY. FT LIPID 403 403 S-palmitoyl cysteine (Potential). FT LIPID 404 404 S-palmitoyl cysteine (Potential). FT LIPID 406 406 S-palmitoyl cysteine (Potential). FT VARIANT 126 126 I -> K (IN OLWS). FT CONFLICT 11 11 V -> A (IN REF. 2). FT CONFLICT 43 44 FE -> SG (IN REF. 2). FT CONFLICT 64 66 PRL -> QRS (IN REF. 2). FT CONFLICT 79 79 A -> E (IN REF. 2). FT CONFLICT 92 92 E -> D (IN REF. 2). FT CONFLICT 297 297 E -> M (IN REF. 2). FT CONFLICT 369 369 E -> D (IN REF. 2). FT CONFLICT 400 400 W -> S (IN REF. 2). SQ SEQUENCE 443 AA; 50006 MW; 74381DDFCF9A9AF4 CRC64; MQPLPTLCGR VLVALILACG VAGVQGEERR FPPARATPPL LGFEEIMTPP TKTSWPTGSN ASVPRLSAPP QMPKAGRTAG AQRRTLPPPP CERTIEIKET FKYINTVVSC LVFVLGIIGN STLLRIIYKN KCMRNGPNIL IASLALGDLL HIIIDIPINV YKLLAEDWPF GVEMCKLVPF IQKASVGITV LSLCALSIDR YRAVASWSRI KGIGVPKWTA VEIVLIWVVS VVLAVPEAVG FDMITADYKG SYLRICLLHP TQKTAFMQFY KNAKDWWLFS FYFCLPLAIT AFFYTLETCE MLRKKSGMQI ALNDHLKQRR EVAKTVFCLV LVFALCWLPL HLSRILKHTL YDQNDPHRCE LLSFLLVLEY IGINMASLNS CINPIALYLV SKRFKNCFKW CLCCWCQSFE EKQSLEDKQS CLKFKANDHG YDNFRSSNKY SSS // ID NY1R_RAT STANDARD; PRT; 382 AA. AC P21555; DT 01-MAY-1991 (Rel. 18, Created) DT 01-MAY-1992 (Rel. 22, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Neuropeptide Y receptor type 1 (NPY1-R) (FC5). GN NPY1R. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=91032093; PubMed=2172008; RA Eva C., Keinaenen K., Monyer H., Seeburg P.H., Sprengel R.; RT "Molecular cloning of a novel G protein-coupled receptor that may RT belong to the neuropeptide receptor family."; RL FEBS Lett. 271:81-84(1990). RN [2] RP REVISIONS, AND FUNCTION. RC TISSUE=Brain; RA Krause J.E., Eva C., Seeburg P.H., Sprengel R.; RL Submitted (NOV-1991) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: RECEPTOR FOR NEUROPEPTIDE Y AND PEPTIDE YY. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Z11504; CAA77579.1; -. DR PIR; S12863; S12863. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 61 1 (POTENTIAL). FT DOMAIN 62 71 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 72 93 2 (POTENTIAL). FT DOMAIN 94 113 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 114 135 3 (POTENTIAL). FT DOMAIN 136 155 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 156 176 4 (POTENTIAL). FT DOMAIN 177 209 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 210 231 5 (POTENTIAL). FT DOMAIN 232 262 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 263 285 6 (POTENTIAL). FT DOMAIN 286 298 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 299 322 7 (POTENTIAL). FT DOMAIN 323 382 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 11 11 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 17 17 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 112 197 BY SIMILARITY. FT LIPID 337 337 S-palmitoyl cysteine (Potential). SQ SEQUENCE 382 AA; 44116 MW; 1D6AA038065C07C3 CRC64; MNSTLFSRVE NYSVHYNVSE NSPFLAFEND DCHLPLAVIF TLALAYGAVI ILGVSGNLAL IIIILKQKEM RNVTNILIVN LSFSDLLVAV MCLPFTFVYT LMDHWVFGET MCKLNPFVQC VSITVSIFSL VLIAVERHQL IINPRGWRPN NRHAYIGITV IWVLAVASSL PFVIYQILTD EPFQNVSLAA FKDKYVCFDK FPSDSHRLSY TTLLLVLQYF GPLCFIFICY FKIYIRLKRR NNMMDKIRDS KYRSSETKRI NVMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA MSTMHTDVSK TSLKQASPVA FKKISMNDNE KI // ID PAR2_RAT STANDARD; PRT; 397 AA. AC Q63645; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Proteinase activated receptor 2 precursor (PAR-2) (Thrombin receptor- DE like 1) (Coagulation factor II receptor-like 1). GN F2RL1 OR PAR2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Intestine, and Kidney; RX MEDLINE=96358009; PubMed=8762073; RA Saifeddine M., Al-Ani B., Cheng C.H., Wang L., Hollenberg M.D.; RT "Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and RT activity of receptor-derived peptides in gastric and vascular RT tissue."; RL Br. J. Pharmacol. 118:521-530(1996). CC -!- FUNCTION: Receptor for trypsin and trypsin-like enzymes coupled to CC G proteins that stimulate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: A proteolytic cleavage generates a new amino terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U61373; AAC52703.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal. FT SIGNAL 1 25 POTENTIAL. FT PROPEP 26 36 REMOVED FOR RECEPTOR ACTIVATION FT (BY SIMILARITY). FT CHAIN 37 397 PROTEINASE ACTIVATED RECEPTOR 2. FT DOMAIN 37 75 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 76 101 1 (POTENTIAL). FT DOMAIN 102 110 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 111 130 2 (POTENTIAL). FT DOMAIN 131 149 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 150 171 3 (POTENTIAL). FT DOMAIN 172 190 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 191 211 4 (POTENTIAL). FT DOMAIN 212 241 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 242 260 5 (POTENTIAL). FT DOMAIN 261 285 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 286 308 6 (POTENTIAL). FT DOMAIN 309 323 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 324 347 7 (POTENTIAL). FT DOMAIN 348 397 CYTOPLASMIC (POTENTIAL). FT DOMAIN 383 392 POLY-SER. FT SITE 36 37 CLEAVAGE (BY TRYPSIN) (POTENTIAL). FT DISULFID 148 226 BY SIMILARITY. FT CARBOHYD 23 23 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 222 222 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 397 AA; 44440 MW; 27DE0C3ACABC798D CRC64; MRSLSLAWLL GGITLLAASA SCNRTVNAPG PNSKGRSLIG RLDTPPPITG KGAPVEPGFS VDEFSASVLT GKLTTVFLPV IYIIVFVIGL PSNGMALWVF FFRTKKKHPA VIYMANLALA DLLSVIWFPL KISYHLHGND WTYGDALCKV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP MGHSRKRANI AVGVSLAIWL LIFLVTIPLY VMRQTIYIPA LNITTCHDVL PEEVLVGDMF SYFLSLAIGV FLFPALLTAS AYVLMIKTLR SSAMDEHSEK KRRRAIRLII TVLSMYFICF APSNVLLVVH YFLIKSQRQS HVYALYLVAL CLSTLNSCID PFVYYFVSKD FRDQARNALL CRSVRTVKRM QISLTSNKFS RKSSSYSSSS TSVKTSY // ID ADMR_RAT STANDARD; PRT; 395 AA. AC P31392; Q64166; DT 01-JUL-1993 (Rel. 26, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Adrenomedullin receptor (AM-R) (G10D) (NOW). GN ADMR. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93170475; PubMed=8382168; RA Harrison J.K., Barber C.M., Lynch K.R.; RT "Molecular cloning of a novel rat G-protein-coupled receptor gene RT expressed prominently in lung, adrenal, and liver."; RL FEBS Lett. 318:17-22(1993). RN [2] RP REVISIONS. RA Harrison J.K.; RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=93298237; PubMed=8390839; RA Eva C., Sprengel R.; RT "A novel putative G protein-coupled receptor highly expressed in lung RT and testis."; RL DNA Cell Biol. 12:393-399(1993). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=96029609; PubMed=7592696; RA Kapas S., Catt K.J., Clark A.J.; RT "Cloning and expression of cDNA encoding a rat adrenomedullin RT receptor."; RL J. Biol. Chem. 270:25344-25347(1995). CC -!- FUNCTION: RECEPTOR FOR ADRENOMEDULLIN. THE ACTIVITY OF THIS CC RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE ADENYLATE CC CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: EXPRESSED IN A WIDE VARIETY OF PERIPHERAL CC TISSUES IN THE ADULT RAT WITH PROMINENT EXPRESSION IN LUNG, CC TESTIS, ADRENAL, AND LIVER. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC HIGHEST RESEMBLANCE WITH THE RDC1 ORPHAN RECEPTOR. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L09249; AAB05356.1; -. DR EMBL; L04672; AAA41271.1; -. DR EMBL; S79811; AAB35457.1; -. DR PIR; S29500; S29500. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 53 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 54 75 1 (POTENTIAL). FT DOMAIN 76 86 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 87 109 2 (POTENTIAL). FT DOMAIN 110 123 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 124 145 3 (POTENTIAL). FT DOMAIN 146 166 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 167 189 4 (POTENTIAL). FT DOMAIN 190 213 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 214 235 5 (POTENTIAL). FT DOMAIN 236 254 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 255 276 6 (POTENTIAL). FT DOMAIN 277 295 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 296 316 7 (POTENTIAL). FT DOMAIN 317 395 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 24 24 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 33 33 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 122 198 BY SIMILARITY. FT CONFLICT 8 9 RP -> EA (IN REF. 3). FT CONFLICT 40 40 H -> R (IN REF. 1). FT CONFLICT 261 261 V -> A (IN REF. 3). FT CONFLICT 264 264 V -> A (IN REF. 1). FT CONFLICT 301 301 I -> T (IN REF. 1). FT CONFLICT 366 395 PLQRICTPTPSETCRPPLCLRTPHLHSAIP -> LAAADLH FT THAIRNVQASSLPPNTSPTLCNSIAS (IN REF. 1). SQ SEQUENCE 395 AA; 45196 MW; DA0499C99E48128D CRC64; MSVIPSSRPV STLAPDNDFR EIHNWTELLH LFNQTFSDCH MELNENTKQV VLFVFYLAIF VVGLVENVLV ICVNCRRSGR VGMLNLYILN MAVADLGIIL SLPVWMLEVM LEYTWLWGSF SCRFIHYFYL ANMYSSIFFL TCLSIDRYVT LTNTSPSWQR HQHRIRRAVC AGVWVLSAII PLPEVVHIQL LDGSEPMCLF LAPFETYSAW ALAVALSATI LGFLLPFPLI AVFNILSACR LRRQGQTESR RHCLLMWAYI VVFVICWLPY HVTMLLLTLH TTHIFLHCNL VNFLYFFYEI IDCFSMLHCV ANPILYNFLS PSFRGRLLSL VVRYLPKEQA RAAGGRASSS SSTQHSIIIT KEGSLPLQRI CTPTPSETCR PPLCLRTPHL HSAIP // ID BRS4_BOMOR STANDARD; PRT; 392 AA. AC P47751; DT 01-FEB-1996 (Rel. 33, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE [Phe13]bombesin receptor (Bombesin receptor subtype-4) (BRS-4). GN BB4. OS Bombina orientalis (Oriental fire-bellied toad). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Archeobatrachia; Bombinatoridae; Bombina. OX NCBI_TaxID=8346; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=95320240; PubMed=7597102; RA Nagalla S.R., Barry B.J., Creswick K.C., Eden P., Taylor J.T., RA Spindel E.R.; RT "Cloning of a receptor for amphibian [Phe13]bombesin distinct from RT the receptor for gastrin-releasing peptide: identification of a RT fourth bombesin receptor subtype (BB4)."; RL Proc. Natl. Acad. Sci. U.S.A. 92:6205-6209(1995). RN [2] RP REVISIONS TO C-TERMINUS. RA Spindel E.R.; RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The relative rank potency of bombesin-like peptides for CC this receptor is [Phe13]bombesin > [Leu13]bombesin > GRP > CC neuromedin B. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed only in brain, primarily in cortex CC and forebrain and at low levels in the midbrain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L39358; AAA91102.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00638; BOMBESIN4R. DR PRINTS; PR00358; BOMBESINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 40 Extracellular (Potential). FT TRANSMEM 41 62 1 (Potential). FT DOMAIN 63 81 Cytoplasmic (Potential). FT TRANSMEM 82 102 2 (Potential). FT DOMAIN 103 120 Extracellular (Potential). FT TRANSMEM 121 142 3 (Potential). FT DOMAIN 143 162 Cytoplasmic (Potential). FT TRANSMEM 163 183 4 (Potential). FT DOMAIN 184 219 Extracellular (Potential). FT TRANSMEM 220 240 5 (Potential). FT DOMAIN 241 271 Cytoplasmic (Potential). FT TRANSMEM 272 292 6 (Potential). FT DOMAIN 293 312 Extracellular (Potential). FT TRANSMEM 313 332 7 (Potential). FT DOMAIN 333 392 Cytoplasmic (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT DISULFID 119 202 By similarity. FT LIPID 346 346 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 392 AA; 43461 MW; 497C620209F1DBEB CRC64; MPEGFQSLNQ TLPSAISSIA HLESLNDSFI LGAKQSEDVS PGLEILALIS VTYAVIISVG ILGNTILIKV FFKIKSMQTV PNIFITSLAF GDLLLLLTCV PVDASRYIVD TWMFGRAGCK IISFIQLTSV GVSVFTLTVL SADRYRAIVK PLQLQTSDAV LKTCGKAVCV WIISMLLAAP EAVFSDLYEF GSSEKNTTFE ACAPYPVSEK ILQETHSLIC FLVFYIVPLS IISAYYFLIA KTLYKSTFNM PAEEHTHARK QIESRKRVAK TVLVLVALFA VCWLPNHMLY LYRSFTYHSA VNSSAFHLSA TIFARVLAFS NSCVNPFALY WLSRSFRQHF KKQVYCCKTE PPASQQSPTH SSTITGITAV KGNIQMSEIS ITLLSAYDVK KE // ID GP83_MOUSE STANDARD; PRT; 423 AA. AC P30731; DT 01-APR-1993 (Rel. 25, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Probable G protein-coupled receptor GPR83 precursor (Glucocorticoid- DE induced receptor). GN GPR83 OR GPR72 OR GIR. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. (ISOFORMS 1; 2; 3 AND 4). RX MEDLINE=92123228; PubMed=1663214; RA Harrigan M.T., Campbell N.F., Bourgeois S.; RT "Identification of a gene induced by glucocorticoids in murine RT T-cells: a potential G protein-coupled receptor."; RL Mol. Endocrinol. 5:1331-1338(1991). CC -!- FUNCTION: ORPHAN RECEPTOR. COULD BE A NEUROPEPTIDE Y RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Comment=Experimental confirmation may be lacking for some CC isoforms; CC Name=1; CC IsoId=P30731-1; Sequence=Displayed; CC Name=2; Synonyms=RP39; CC IsoId=P30731-2; Sequence=VSP_001988; CC Name=3; Synonyms=RP82; CC IsoId=P30731-3; Sequence=VSP_001989; CC Name=4; Synonyms=RP105; CC IsoId=P30731-4; Sequence=VSP_001990; CC -!- TISSUE SPECIFICITY: BRAIN, THYMUS AND SPLEEN. CC -!- INDUCTION: By glucocorticoids and cAMP; in T-cells. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M80481; AAA17882.1; -. DR PIR; A40470; A40470. DR PIR; B40470; B40470. DR PIR; C40470; C40470. DR PIR; D40470; D40470. DR MGD; MGI:95712; Gpr83. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Alternative splicing. FT SIGNAL 1 17 POTENTIAL. FT CHAIN 18 423 PROBABLE G PROTEIN-COUPLED RECEPTOR FT GPR83. FT DOMAIN 18 71 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 72 92 1 (POTENTIAL). FT DOMAIN 93 107 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 108 129 2 (POTENTIAL). FT DOMAIN 130 145 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 146 167 3 (POTENTIAL). FT DOMAIN 168 186 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 187 208 4 (POTENTIAL). FT DOMAIN 209 238 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 239 260 5 (POTENTIAL). FT DOMAIN 261 293 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 294 315 6 (POTENTIAL). FT DOMAIN 316 327 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 328 348 7 (POTENTIAL). FT DOMAIN 349 423 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 38 38 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 46 46 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 134 134 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 144 224 BY SIMILARITY. FT VARSPLIC 130 171 Missing (in isoform 2). FT /FTId=VSP_001988. FT VARSPLIC 171 171 Q -> QGLTAIAVDRHQGLELQKMVRPRGDGGELRSPSVTF FT VPSSLCPALFTCKRPWDFQESQSLHDTLFPPLE (in FT isoform 3). FT /FTId=VSP_001989. FT VARSPLIC 171 171 Q -> QRPWDFQESQSLHDTLFPPLE (in isoform FT 4). FT /FTId=VSP_001990. SQ SEQUENCE 423 AA; 48136 MW; 3ACE43452BF15391 CRC64; MKVPPVLLLF LLSSVRATEQ PQVVTEHPSM EAALTGPNAS SHFWANYTFS DWQNFVGRRR YGAESQNPTV KALLIVAYSF TIVFSLFGNV LVCHVIFKNQ RMHSATSLFI VNLAVADIMI TLLNTPFTLV RFVNSTWVFG KGMCHVSRFA QYCSLHVSAL TLTAIAVDRH QVIMHPLKPR ISITKGVIYI AVIWVMATFF SLPHAICQKL FTFKYSEDIV RSLCLPDFPE PADLFWKYLD LATFILLYLL PLFIISVAYA RVAKKLWLCN TIGDVTTEQY LALRRKKKTT VKMLVLVVVL FALCWFPLNC YVLLLSSKAI HTNNALYFAF HWFAMSSTCY NPFIYCWLNE NFRVELKALL SMCQRPPKPQ EDRLPSPVPS FRVAWTEKSH GRRAPLPNHH LPSSQIQSGK TDLSSVEPVV AMS // ID OXYR_MACMU STANDARD; PRT; 389 AA. AC P56494; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE Oxytocin receptor (OT-R). GN OXTR. OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98152559; PubMed=9493565; RA Salvatore C.A., Woyden C.J., Guidotti M.T., Pettibone D.J., RA Jacobson M.A.; RT "Cloning and expression of the rhesus monkey oxytocin receptor."; RL J. Recept. Signal Transduct. Res. 18:15-24(1998). CC -!- FUNCTION: RECEPTOR FOR OXYTOCIN. THE ACTIVITY OF THIS RECEPTOR IS CC MEDIATED BY G PROTEINS WHICH ACTIVATE A PHOSPHATIDYLINOSITOL- CC CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U82440; AAC52031.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 63 1 (POTENTIAL). FT DOMAIN 64 74 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 75 97 2 (POTENTIAL). FT DOMAIN 98 113 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 114 135 3 (POTENTIAL). FT DOMAIN 136 154 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 155 175 4 (POTENTIAL). FT DOMAIN 176 202 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 203 225 5 (POTENTIAL). FT DOMAIN 226 275 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 276 294 6 (POTENTIAL). FT DOMAIN 295 309 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 310 332 7 (POTENTIAL). FT DOMAIN 333 389 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 15 15 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 26 26 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 112 187 BY SIMILARITY. SQ SEQUENCE 389 AA; 42913 MW; C7EAD8D6F9C51D7B CRC64; MEGELAANWS TEAVNSSAAP PGAEGNCTAG PPRRNEALAR VEVAVLCLIL FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AEAPEGAAAG DGGRMALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGNRLGET STSKKSNSSS FVLSHRSSSQ RSCSQPSTA // ID V1BR_MOUSE STANDARD; PRT; 421 AA. AC Q9WU02; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Vasopressin V1b receptor (V1bR) (AVPR V1b) (Vasopressin V3 receptor) DE (AVPR V3) (Antidiuretic hormone receptor 1b). GN AVPR1B OR V1BR. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=129/Sv; RX MEDLINE=99280345; PubMed=10343284; RA Ventura M.A., Rene P., de Keyzer Y., Bertagna X., Clauser E.; RT "Gene and cDNA cloning and characterization of the mouse V3/V1b RT pituitary vasopressin receptor."; RL J. Mol. Endocrinol. 22:251-260(1999). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=129/SvJ; RX MEDLINE=20132529; PubMed=10669045; RA Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.; RT "Structure and sequence of the mouse V1a and V1b vasopressin receptor RT genes."; RL Jpn. J. Pharmacol. 81:388-392(1999). CC -!- FUNCTION: RECEPTOR FOR ARGININE VASOPRESSIN. THE ACTIVITY OF THIS CC RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE A PHOSPHATIDYL- CC INOSITOL-CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF098867; AAD27957.1; -. DR EMBL; AF098866; AAD27957.1; JOINED. DR EMBL; AB030449; BAA89205.1; -. DR EMBL; AB030448; BAA89205.1; JOINED. DR MGD; MGI:1347010; Avpr1b. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 35 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 36 59 1 (POTENTIAL). FT DOMAIN 60 71 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 72 93 2 (POTENTIAL). FT DOMAIN 94 108 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 109 130 3 (POTENTIAL). FT DOMAIN 131 151 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 152 173 4 (POTENTIAL). FT DOMAIN 174 202 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 203 223 5 (POTENTIAL). FT DOMAIN 224 280 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 281 300 6 (POTENTIAL). FT DOMAIN 301 318 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 319 338 7 (POTENTIAL). FT DOMAIN 339 421 CYTOPLASMIC (POTENTIAL). FT DISULFID 107 186 BY SIMILARITY. FT CARBOHYD 21 21 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 421 AA; 46539 MW; E867DC0C700F596F CRC64; MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLILG LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE RRGWPKSSSS AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR ACCRGSKPRV HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP AGSLKDLEQV DGEATMETSI S // ID NY6R_RABIT STANDARD; PRT; 371 AA. AC P79217; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Neuropeptide Y receptor type 6 (NPY6-R). GN NPY6R. OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Lagomorpha; Leporidae; Oryctolagus. OX NCBI_TaxID=9986; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Japanese white; TISSUE=Skeletal muscle; RX MEDLINE=97066888; PubMed=8910290; RA Matsumoto M., Nomura T., Momose K., Ikeda Y., Kondou Y., Akiho H., RA Togami J., Kimura Y., Okada M., Yamaguchi T.; RT "Inactivation of a novel neuropeptide Y/peptide YY receptor gene in RT primate species."; RL J. Biol. Chem. 271:27217-27220(1996). CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity CC of this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D86521; BAA13104.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 34 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 35 57 1 (POTENTIAL). FT DOMAIN 58 69 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 70 90 2 (POTENTIAL). FT DOMAIN 91 110 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 111 132 3 (POTENTIAL). FT DOMAIN 133 152 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 153 174 4 (POTENTIAL). FT DOMAIN 175 208 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 209 230 5 (POTENTIAL). FT DOMAIN 231 261 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 262 284 6 (POTENTIAL). FT DOMAIN 285 297 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 298 321 7 (POTENTIAL). FT DOMAIN 322 371 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 11 11 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 182 182 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 109 196 BY SIMILARITY. FT LIPID 336 336 S-palmitoyl cysteine (Potential). SQ SEQUENCE 371 AA; 42447 MW; 5847E358EE320F24 CRC64; MEVSLNDPAS NKTSAKSNSS AFFYFESCQS PSLALLLLLI AYTVVLIMGI CGNLSLITII FKKQREAQNV TNILIANLSL SDILVCVMCI PFTAIYTLMD RWIFGNTMCK LTSYVQSVSI SVSIFSLVLI AIERYQLIVN PRGWKPSASH AYWGIMLIWL FSLLLSIPLL LSYHLTDEPF RNLSLPTDLY SHHVVCVEHW PSKTNQLLYS TSLIMLQYFV PLGFMFICYL KIVICLHKRN SKIDRRRENE SRLTENKRIN TMLISIVVTF AACWLPLNTF NVIFDWYHEV LMSCHHDLVF AICHLVAMVS TCINPLFYGF LNRNFQKDLV VLIHHCLCFA LRERYENIAI STLHTDESKG SLRVAHIPAG I // ID OXYR_RAT STANDARD; PRT; 388 AA. AC P70536; DT 01-NOV-1997 (Rel. 35, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Oxytocin receptor (OT-R). GN OXTR OR OTR. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Liver; RX MEDLINE=95116525; PubMed=7816817; RA Rozen F., Russo C., Banville D., Zingg H.H.; RT "Structure, characterization, and expression of the rat oxytocin RT receptor gene."; RL Proc. Natl. Acad. Sci. U.S.A. 92:200-204(1995). RN [2] RP REVISION TO 84. RA Zingg H.H.; RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: RECEPTOR FOR OXYTOCIN. THE ACTIVITY OF THIS RECEPTOR IS CC MEDIATED BY G PROTEINS WHICH ACTIVATE A PHOSPHATIDYLINOSITOL- CC CALCIUM SECOND MESSENGER SYSTEM. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U15280; AAC53245.2; -. DR EMBL; U15169; AAC53245.2; JOINED. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 63 1 (POTENTIAL). FT DOMAIN 64 74 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 75 97 2 (POTENTIAL). FT DOMAIN 98 113 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 114 135 3 (POTENTIAL). FT DOMAIN 136 154 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 155 175 4 (POTENTIAL). FT DOMAIN 176 202 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 203 225 5 (POTENTIAL). FT DOMAIN 226 274 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 275 293 6 (POTENTIAL). FT DOMAIN 294 308 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 309 331 7 (POTENTIAL). FT DOMAIN 332 388 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 26 26 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 112 187 BY SIMILARITY. FT DOMAIN 129 132 POLY-LEU. FT DOMAIN 236 242 POLY-ALA. SQ SEQUENCE 388 AA; 42868 MW; FC738B254005CDD0 CRC64; MEGTPAANWS VELDLGSGVP PGEEGNRTAG PPQRNEALAR VEVAVLCLIL FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLGT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGNDAAGG AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFFCCSARY LKGSRPGETS VSKKSNSSTF VLSRRSSSQR SCSQPSSA // ID C3AR_RAT STANDARD; PRT; 473 AA. AC O55197; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE C3a anaphylatoxin chemotactic receptor (C3a-R) (C3AR). GN C3AR1. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Wistar; TISSUE=Lung; RX MEDLINE=98125550; PubMed=9464274; RA Fukuoka Y., Ember J.A., Hugli T.E.; RT "Cloning and characterization of rat C3a receptor: differential RT expression of rat C3a and C5a receptors by LPS stimulation."; RL Biochem. Biophys. Res. Commun. 242:663-668(1998). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C3a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U86379; AAC40071.1; -. DR PIR; JC5835; JC5835. DR RGD; 620537; C3ar1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR01060; C3ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Chemotaxis; Sulfation. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 46 1 (Potential). FT DOMAIN 47 57 Cytoplasmic (Potential). FT TRANSMEM 58 80 2 (Potential). FT DOMAIN 81 96 Extracellular (Potential). FT TRANSMEM 97 118 3 (Potential). FT DOMAIN 119 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 329 Extracellular (Potential). FT TRANSMEM 330 349 5 (Potential). FT DOMAIN 350 366 Cytoplasmic (Potential). FT TRANSMEM 367 389 6 (Potential). FT DOMAIN 390 406 Extracellular (Potential). FT TRANSMEM 407 427 7 (Potential). FT DOMAIN 428 473 Cytoplasmic (Potential). FT DISULFID 95 172 By similarity. FT MOD_RES 174 174 Sulfotyrosine (By similarity). FT MOD_RES 184 184 Sulfotyrosine (By similarity). FT MOD_RES 308 308 Sulfotyrosine (By similarity). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 201 201 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 473 AA; 52896 MW; 722F16F6F4B16451 CRC64; MESFTADTNS TDLHSRPLFK PQDIASMVIL SLTCLLGLPG NGLVLWVAGV KMKRTVNTVW FLHLTLADFL CCLSLPFSVA HLILRGHWPY GLFLCKLIPS VIILNMFASV FLLTAISLDR CLMVHKPIWC QNHRSVRTAF AVCGCVWVVT FVMCIPVFVY RDLLVVDDYS VCGYNFDSSR AYDYWDYMYN SHLPEINPPD NSTGHVDDRT APSSSVPARD LWTATTALQS QTFHTSPEDP FSQDSASQQP HYGGKPPTVL IATIPGGFPV EDHKSNTLNT GAFLSAHTEP SLTASSSPLY AHDFPDDYFD QLMYGNHAWT PQVAITISRL VVGFLVPFFI MITCYSLIVF RMRKTNLTKS RNKTLRVAVA VVTVFFVCWI PYHIVGILLV ITDQESALRE VVLPWDHMSI ALASANSCFN PFLYALLGKD FRKKARQSVK GILEAAFSEE LTHSTSCTQD KAPSKRNHMS TDV // ID UR2R_HUMAN STANDARD; PRT; 389 AA. AC Q9UKP6; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Urotensin II receptor (UR-II-R) (G protein coupled receptor 14). GN GPR14. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99427933; PubMed=10499587; RA Ames R.S., Sarau H.M., Chambers J.K., Willette R.N., Aiyar N.V., RA Romanic A.M., Louden C.S., Foley J.J., Sauermelch C.F., Coatney R.W., RA Ao Z., Disa J., Holmes S.D., Stadel J.M., Martin J.D., Liu W.-S., RA Glover G.I., Wilson S., McNulty D.E., Ellis C.E., Elshourbagy N.A., RA Shabon U., Trill J.J., Hay D.W.P., Ohlstein E.H., Bergsma D.J., RA Douglas S.A.; RT "Human urotensin-II is a potent vasoconstrictor and agonist for the RT orphan receptor GPR14."; RL Nature 401:282-286(1999). CC -!- FUNCTION: High afinity receptor for urotensin II. The activity of CC this receptor is mediated by a G-protein that activate a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Most abundant expression in the heart and CC pancreas. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF140631; AAD55578.1; -. DR Genew; HGNC:4468; GPR14. DR MIM; 600896; -. DR GO; GO:0016020; C:membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0008015; P:circulation; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 54 Extracellular (Potential). FT TRANSMEM 55 77 1 (Potential). FT DOMAIN 78 87 Cytoplasmic (Potential). FT TRANSMEM 88 113 2 (Potential). FT DOMAIN 114 124 Extracellular (Potential). FT TRANSMEM 125 146 3 (Potential). FT DOMAIN 147 167 Cytoplasmic (Potential). FT TRANSMEM 168 186 4 (Potential). FT DOMAIN 187 209 Extracellular (Potential). FT TRANSMEM 210 232 5 (Potential). FT DOMAIN 233 258 Cytoplasmic (Potential). FT TRANSMEM 259 284 6 (Potential). FT DOMAIN 285 297 Extracellular (Potential). FT TRANSMEM 298 318 7 (Potential). FT DOMAIN 319 389 Cytoplasmic (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT DISULFID 123 199 By similarity. SQ SEQUENCE 389 AA; 42130 MW; 6D6A88DBF78400CE CRC64; MALTPESPSS FPGLAATGSS VPEPPGGPNA TLNSSWASPT EPSSLEDLVA TGTIGTLLSA MGVVGVVGNA YTLVVTCRSL RAVASMYVYV VNLALADLLY LLSIPFIVAT YVTKEWHFGD VGCRVLFGLD FLTMHASIFT LTVMSSERYA AVLRPLDTVQ RPKGYRKLLA LGTWLLALLL TLPVMLAMRL VRRGPKSLCL PAWGPRAHRA YLTLLFATSI AGPGLLIGLL YARLARAYRR SQRASFKRAR RPGARALRLV LGIVLLFWAC FLPFWLWQLL AQYHQAPLAP RTARIVNYLT TCLTYGNSCA NPFLYTLLTR NYRDHLRGRV RGPGSGGGRG PVPSLQPRAR FQRCSGRSLS SCSPQPTDSL VLAPAAPARP APEGPRAPA // ID MCR1_MOUSE STANDARD; PRT; 423 AA. AC Q8JZL2; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCHR-1) DE (MCH-R1) (MCH1R) (MCH-1R) (MCHR) (G protein coupled receptor 24) DE (Somatostatin receptor-like protein) (SLC-1). GN GPR24 OR MCHR1 OR SLC1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE OF 71-423 FROM N.A. RC STRAIN=129/SvJ; RA Lakaye B., Adamantidis A., Coumans B., Zorzi W., Parmentier M., RA Grisar T.; RT "Cloning of the mouse melanin-concentrating hormone receptor 1 gene RT and promoter characterization."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 71-423 FROM N.A. RC STRAIN=ILS, and ISS; RX MEDLINE=21363810; PubMed=11471062; RA Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., RA Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.; RT "High-throughput sequence identification of gene coding variants RT within alcohol-related QTLs."; RL Mamm. Genome 12:657-663(2001). RN [3] RP SEQUENCE OF 71-423 FROM N.A. RC STRAIN=ILS, and ISS; RA Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., RA Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE OF 1-129 FROM N.A. RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [5] RP CONCEPTUAL TRANSLATION OF 1-129. RA Farriol-Mathis N.; RL Unpublished observations (JUL-2002). CC -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to CC both G proteins that inhibit adenylyl cyclase and G proteins that CC activate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- CAUTION: It is uncertain whether Met-1 or Met-71 is the initiator. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY049011; AAL06069.1; -. DR EMBL; AF498247; AAM22964.1; -. DR EMBL; AF498248; AAM22965.1; -. DR EMBL; BY276741; -; NOT_ANNOTATED_CDS. DR MGD; MGI:2180756; Gpr24. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR004047; MCH1_receptor. DR InterPro; IPR008361; MCH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01507; MCH1RECEPTOR. DR PRINTS; PR01783; MCHRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 114 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 115 137 1 (POTENTIAL). FT DOMAIN 138 149 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 150 172 2 (POTENTIAL). FT DOMAIN 173 186 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 187 209 3 (POTENTIAL). FT DOMAIN 210 229 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 230 252 4 (POTENTIAL). FT DOMAIN 253 279 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 280 302 5 (POTENTIAL). FT DOMAIN 303 322 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 323 345 6 (POTENTIAL). FT DOMAIN 346 359 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 360 382 7 (POTENTIAL). FT DOMAIN 383 423 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 83 83 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 86 86 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 93 93 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 423 AA; 46269 MW; 9E26A7DB9D494569 CRC64; MSVGAGKEGV GRAVGLRGSR GCQAVEEDPF LDCGAQAPGQ GGGGRWRLPQ PAWVDGRALH SREQATCTGC MDLQASLLST GPNASNISDG QDNFTLAGPP PRTRSVSYIN IIMPSVFGTI CLLGIVGNST VIFAVVKKSK LHWCSNVPDI FIINLSVVDL LFLLGMPFMI HQLMGNGVWH FGETMCTLIT AMDANSQFTS TYILTAMAID RYLATVHPIS STKFRKPSMA TLVICLLWAL SFISITPVWL YARLIPFPGG AVGCGIRLPN PDTDLYWFTL YQFFLAFALP FVVITAAYVK ILQRMTSSVA PASQRSIRLR TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV YLYNAAISLG YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRTVSNA QTADEERTES KGT // ID ETBR_COTJA STANDARD; PRT; 347 AA. AC Q90328; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Endothelin B receptor (ET-B) (Endothelin receptor non-selective type) DE (Fragment). GN EDNRB. OS Coturnix coturnix japonica (Japanese quail). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Coturnix. OX NCBI_TaxID=93934; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=96382520; PubMed=8790384; RA Nataf V., Lecoin L., Eichmann A., le Douarin N.M.; RT "Endothelin-B receptor is expressed by neural crest cells in the RT avian embryo."; RL Proc. Natl. Acad. Sci. U.S.A. 93:9645-9650(1996). CC -!- FUNCTION: NON-SPECIFIC RECEPTOR FOR ENDOTHELIN 1, 2, AND 3. CC MEDIATES ITS ACTION BY ASSOCIATION WITH G PROTEINS THAT ACTIVATE A CC PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM (BY CC SIMILARITY). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X99295; CAA67681.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate. FT NON_TER 1 1 FT DOMAIN <1 7 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 8 32 1 (POTENTIAL). FT DOMAIN 33 43 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 44 69 2 (POTENTIAL). FT DOMAIN 70 81 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 82 103 3 (POTENTIAL). FT DOMAIN 104 124 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 125 149 4 (POTENTIAL). FT DOMAIN 150 177 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 178 202 5 (POTENTIAL). FT DOMAIN 203 230 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 231 256 6 (POTENTIAL). FT DOMAIN 257 268 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 269 295 7 (POTENTIAL). FT DOMAIN 296 347 CYTOPLASMIC (POTENTIAL). FT DISULFID 80 161 BY SIMILARITY. FT LIPID 309 309 S-palmitoyl cysteine (By similarity). FT LIPID 311 311 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 347 AA; 39825 MW; 3F6A03F8E6895D30 CRC64; EIKETFKYIN TVVSCLVFVL GIIGNSTLLR IIYKNKCMRN GPNILIASLA LGDLLHIIID IPISVYKLLA EDWPFGVEMC KLVPFIQKAS VGITVLSLCA LSIDRYRAVA SWSRIKGIGV PKWTAVEIVL IWVISVVLAV PEAIAFDMIT MEYRGKDLRI CLLHPTQKTS FMMFYKQAKD WWLFSFYFCL PLAITALFYT LMTCEMLRKK SGMQIALNDH LKQRREVAKT VFCLVLVFAL CWLPLHLSRI LKLTIYDQKD PNRCELLSFF LVMDYIGINM ASLNSCINPI ALYLVSKRFQ NCFKSCLCCW CQSKDLLSLE ERQSCLKFKA NDHGYDNFRS SNKYSSS // ID PAR4_RAT STANDARD; PRT; 395 AA. AC Q920E0; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Proteinase activated receptor 4 precursor (PAR-4) (Thrombin receptor- DE like 3) (Coagulation factor II receptor-like 3). GN F2RL3 OR PAR4. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Duodenum; RA Hoogerwerf W.A., Lee-Hellmich H., Pasricha P.J.; RT "Proteinase activated receptor 4 from rat duodenal library."; RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Myometrium; RA Chien E.K., Marietti S., Mendoza J., Phillippe M.; RT "Cloning of the rat protease activated receptor isoforms 3 and 4."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for activated thrombin or trypsin coupled to G CC proteins that stimulate phosphoinositide hydrolysis. May play a CC role in platelets activation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: A proteolytic cleavage generates a new amino terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF310216; AAL26790.1; -. DR EMBL; AF269246; AAK58604.2; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Blood coagulation. FT SIGNAL 1 16 POTENTIAL. FT PROPEP 17 58 REMOVED FOR RECEPTOR ACTIVATION FT (BY SIMILARITY). FT CHAIN 59 395 PROTEINASE ACTIVATED RECEPTOR 4. FT DOMAIN 59 93 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 94 114 1 (POTENTIAL). FT DOMAIN 115 119 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 120 140 2 (POTENTIAL). FT DOMAIN 141 161 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 162 182 3 (POTENTIAL). FT DOMAIN 183 203 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 204 224 4 (POTENTIAL). FT DOMAIN 225 254 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 255 275 5 (POTENTIAL). FT DOMAIN 276 295 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 296 316 6 (POTENTIAL). FT DOMAIN 317 330 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 331 354 7 (POTENTIAL). FT DOMAIN 355 395 CYTOPLASMIC (POTENTIAL). FT SITE 58 59 CLEAVAGE (BY THROMBIN) (BY SIMILARITY). FT DOMAIN 98 101 POLY-VAL. FT DOMAIN 373 376 POLY-SER. FT DISULFID 160 239 BY SIMILARITY. FT CONFLICT 1 9 MISSING (IN REF. 2). FT CONFLICT 192 192 S -> P (IN REF. 2). SQ SEQUENCE 395 AA; 42943 MW; 43B36D0DA22FAFAC CRC64; MCWPLLYPLM LGFSISPAEC QTPSIYDDVE STREGQEASL RPTVELNESK SPDKPNPRGF PGKPCANNSD TLELPASSEA LLLGWVPTRL VPAIYGLVVV VGLPANGLAL WVLATRVPRL PSTILLMNLA VADLLLALVL PPRLVYHLRG QRWPFGEAAC RVATAALYGH MYGSVLLLAA VSLDRYLALV HSLRARALRG QRLTTILCLV AWLSAATLVL PLTFHRQTFL LAGSDRMLCH DALPLAEQTS HWRPAFICLA VLGCFVPLLA MVLCYGATLR ALAANGQRYS HAVRLTALVL FSAVAAFTPS NVLLVLHYSN PSPEAWGNLY GAYVPSLALS TLNSCVDPFI YYYVSHEFRE KVRAMLCRQL KASSSSQASR EAGSRGTAIC SSTLL // ID V2R_BOVIN STANDARD; PRT; 370 AA. AC P48044; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Vasopressin V2 receptor (Renal-type arginine vasopressin receptor) DE (Antidiuretic hormone receptor) (AVPR V2). GN AVPR2. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Kidney; RX MEDLINE=95212574; PubMed=7698346; RA Ufer E., Postina R., Gorbulev V., Fahrenholz F.; RT "An extracellular residue determines the agonist specificity of V2 RT vasopressin receptors."; RL FEBS Lett. 362:19-23(1995). CC -!- FUNCTION: RECEPTOR FOR ARGININE VASOPRESSIN. THE ACTIVITY OF THIS CC RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE ADENYLATE CC CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X83741; CAA58709.1; -. DR PIR; S68777; S68777. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 63 1 (POTENTIAL). FT DOMAIN 64 77 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 78 98 2 (POTENTIAL). FT DOMAIN 99 113 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 114 135 3 (POTENTIAL). FT DOMAIN 136 159 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 160 180 4 (POTENTIAL). FT DOMAIN 181 199 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 200 219 5 (POTENTIAL). FT DOMAIN 220 270 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 271 292 6 (POTENTIAL). FT DOMAIN 293 307 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 308 327 7 (POTENTIAL). FT DOMAIN 328 370 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 22 22 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 340 340 S-palmitoyl cysteine (By similarity). FT LIPID 341 341 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 370 AA; 40236 MW; 5FDCCC2CD21DD4AE CRC64; MFMASTTSAV PWHLSQPTPA GNGSEGELLT ARDPLLAQAE LALLSTVFVA VALSNGLVLG ALVRRGRRGR WAPMHVFIGH LCLADLAVAL FQVLPQLAWD ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAHRH GGGTHWNRPV LLAWAFSLLF SLPQLFIFAQ RDVDGSGVLD CWARFAEPWG LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHASLGPGPV PRAGGPRRGC RPGSPAEGAR VSAAVAKTVK MTLVIVIVYV LCWAPFFLVQ LWAAWDPEAP REGPPFVLLM LLASLNSCTN PWIYASFSSS ISSELRSLLC CTWRRAPPSP GPQEESCATA SSFLAKDTPS // ID PKR1_MOUSE STANDARD; PRT; 393 AA. AC Q9JKL1; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Prokineticin receptor 1 (PK-R1) (G protein-coupled receptor 73). GN GPR73 OR PKR1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=20225484; PubMed=10760605; RA Parker R., Liu M., Eyre H.J., Copeland N.G., Gilbert D.J., RA Crawford J., Sutherland G.R., Jenkins N.A., Herzog H.; RT "Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic RT organisation and assignment to human chromosome 11q21.1 and 2p14 and RT mouse chromosome 9 and 6."; RL Biochim. Biophys. Acta 1491:369-375(2000). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6; RX MEDLINE=22022134; PubMed=12024206; RA Cheng M.Y., Bullock C.M., Li C., Lee A.G., Bermak J.C., Belluzzi J., RA Weaver D.R., Leslie F.M., Zhou Q.-Y.; RT "Prokineticin 2 transmits the behavioural circadian rhythm of the RT suprachiasmatic nucleus."; RL Nature 417:405-410(2002). CC -!- FUNCTION: Receptor for prokineticin 1. Exclusively coupled to the CC G(q) subclass of heteromeric G proteins. Activation leads to CC mobilization of calcium, stimulation of phosphoinositide turnover CC and activation of p44/p42 mitogen-activated protein kinase (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed at high levels in the heart, CC skeletal muscle and pancreas. Expressed at lower levels in the CC brain, lung, liver and kidney. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF236082; AAF43706.1; -. DR EMBL; AF487278; AAM49570.1; -. DR MGD; MGI:1929676; Gpr73. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 62 Extracellular (Potential). FT TRANSMEM 63 83 1 (Potential). FT DOMAIN 84 98 Cytoplasmic (Potential). FT TRANSMEM 99 119 2 (Potential). FT DOMAIN 120 146 Extracellular (Potential). FT TRANSMEM 147 167 3 (Potential). FT DOMAIN 168 179 Cytoplasmic (Potential). FT TRANSMEM 180 200 4 (Potential). FT DOMAIN 201 232 Extracellular (Potential). FT TRANSMEM 233 253 5 (Potential). FT DOMAIN 254 282 Cytoplasmic (Potential). FT TRANSMEM 283 303 6 (Potential). FT DOMAIN 304 322 Extracellular (Potential). FT TRANSMEM 323 343 7 (Potential). FT DOMAIN 344 393 Cytoplasmic (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT DISULFID 137 217 By similarity. SQ SEQUENCE 393 AA; 44528 MW; 46F5E78C00DC871C CRC64; METTVGALGE NTTDTFTDFF SALDGHEAQT GSLPFTFSYG DYDMPLDEEE DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCASV NYLRTVSLYV STNALLAIAI DRYLAIVHPL RPRMKCQTAA GLIFLVWSVS ILIAIPAAYF TTETVLVIVE RQEKIFCGQI WPVDQQFYYR SYFLLVFGLE FVGPVVAMTL CYARVSRELW FKAVPGFQTE QIRRTVRCRR RTVLGLVCVL SAYVLCWAPF YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS KYLKRILRLQ WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK // ID MSHR_BOVIN STANDARD; PRT; 317 AA. AC P47798; Q28025; DT 01-FEB-1996 (Rel. 33, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R) (BDF3). GN MC1R OR MSHR. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94307438; PubMed=8034052; RA Vanetti M., Schoenrock C., Meyerhof W., Hoellt V.; RT "Molecular cloning of a bovine MSH receptor which is highly expressed RT in the testis."; RL FEBS Lett. 348:268-272(1994). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Holstein; RX MEDLINE=96325106; PubMed=8661706; RA Joerg H., Fries H.R., Meijerink E., Stranzinger G.F.; RT "Red coat color in Holstein cattle is associated with a deletion in RT the MSHR gene."; RL Mamm. Genome 7:317-318(1996). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=20093783; PubMed=10628296; RA Klungland H., Roed K.H., Nesbo C.L., Jakobsen K.S., Vage D.I.; RT "The melanocyte-stimulating hormone receptor (MC1-R) gene as a tool RT in evolutionary studies of artiodactyles."; RL Hereditas 131:39-46(1999). RN [4] RP SEQUENCE FROM N.A. RC STRAIN=Holstein; RA Kriegesmann B., Brenig B., Dierkes B., Jansen S.; RT "A new melanocortin 1-receptor allele is coupled with Agouti coat RT colour pattern in Holstein cattle."; RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: RECEPTOR FOR MSH (ALPHA, BETA) AND ACTH. DOES NOT SEEM CC TO BE ACTIVE WITH GAMMA-MSH. THE ACTIVITY OF THIS RECEPTOR IS CC MEDIATED BY G PROTEINS WHICH ACTIVATE ADENYLATE CYCLASE. COULD BE CC INVOLVED IN SPERMATOGENESIS. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: HIGHLY EXPRESSED IN THE TESTIS. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S71017; AAB31361.1; -. DR EMBL; U39469; AAC48590.2; -. DR EMBL; Y13957; CAA74291.1; -. DR EMBL; Y19103; CAB64818.1; -. DR PIR; S45708; S45708. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 38 63 1 (POTENTIAL). FT DOMAIN 64 72 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 73 93 2 (POTENTIAL). FT DOMAIN 94 118 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 119 140 3 (POTENTIAL). FT DOMAIN 141 163 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 164 183 4 (POTENTIAL). FT DOMAIN 184 191 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 192 211 5 (POTENTIAL). FT DOMAIN 212 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 266 6 (POTENTIAL). FT DOMAIN 267 279 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 280 300 7 (POTENTIAL). FT DOMAIN 301 317 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 29 29 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CONFLICT 40 41 IP -> SL (IN REF. 1). FT CONFLICT 99 99 L -> P (IN REF. 1 AND 2). SQ SEQUENCE 317 AA; 34916 MW; 123692614F7FF168 CRC64; MPALGSQRRL LGSLNCTPPA TLPFTLAPNR TGPQCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SPMYYFICCL AVSDLLVSVS NVLETAVMLL LEAGVLATQA AVVQQLDNVI DVLICGSMVS SLCFLGAIAV DRYISIFYAL RYHSVVTLPR AWRIIAAIWV ASILTSLLFI TYYNHKVILL CLVGLFIAML ALMAVLYVHM LARACQHARG IARLQKRQRP IHQGFGLKGA ATLTILLGVF FLCWGPFFLH LSLIVLCPQH PTCGCIFKNF NLFLALIICN AIVDPLIYAF RSQELRKTLQ EVLQCSW // ID NY5R_CANFA STANDARD; PRT; 446 AA. AC O62729; DT 15-DEC-1998 (Rel. 37, Created) DT 15-DEC-1998 (Rel. 37, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (Y5 DE receptor) (NPYY5). GN NPY5R OR NPY5. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99017379; PubMed=9802393; RA Borowsky B., Walker M.W., Bard J., Weinshank R.L., Laz T.M., RA Vaysse P., Branchek T.A., Gerald C.; RT "Molecular biology and pharmacology of multiple NPY Y5 receptor RT species homologs."; RL Regul. Pept. 75:45-53(1998). CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity CC of this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. Seems to be associated with food intake. Could CC be involved in feeding disorders (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF049328; AAC17838.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 40 Extracellular (Potential). FT TRANSMEM 41 62 1 (Potential). FT DOMAIN 63 74 Cytoplasmic (Potential). FT TRANSMEM 75 95 2 (Potential). FT DOMAIN 96 115 Extracellular (Potential). FT TRANSMEM 116 137 3 (Potential). FT DOMAIN 138 157 Cytoplasmic (Potential). FT TRANSMEM 158 178 4 (Potential). FT DOMAIN 179 210 Extracellular (Potential). FT TRANSMEM 211 232 5 (Potential). FT DOMAIN 233 368 Cytoplasmic (Potential). FT TRANSMEM 369 391 6 (Potential). FT DOMAIN 392 404 Extracellular (Potential). FT TRANSMEM 405 428 7 (Potential). FT DOMAIN 429 446 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 114 198 By similarity. FT LIPID 442 442 S-palmitoyl cysteine (Potential). SQ SEQUENCE 446 AA; 51012 MW; 5CAC8D2FCF5D254A CRC64; MDLELQDFYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF VSLLGFMGNL LILMALMRKR NQKTMVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELQETFDSA LLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSNKENKLE ENEMINLTLQ PFKKSGPQVK LSSSHKWSYS FIRKHRRRYS KKTACVLPAP ARPPQENHSR MLPENFGSVR SQHSSSSKFI PGVPTCFEVK PEENSDVHDM RVNRSIMRIK KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLISLI QCLHMS // ID MSHR_RANTA STANDARD; PRT; 317 AA. AC P56448; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R OR MSHR. OS Rangifer tarandus (Reindeer) (Caribou). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Cervidae; OC Odocoileinae; Rangifer. OX NCBI_TaxID=9870; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20093783; PubMed=10628296; RA Klungland H., Roed K.H., Nesbo C.L., Jakobsen K.S., Vage D.I.; RT "The melanocyte-stimulating hormone receptor (MC1-R) gene as a tool RT in evolutionary studies of artiodactyles."; RL Hereditas 131:39-46(1999). CC -!- FUNCTION: Receptor for MSH (alpha, beta) and ACTH. Does not seem CC to be active with gamma-MSH. The activity of this receptor is CC mediated by G proteins which activate adenylate cyclase. Could be CC involved in spermatogenesis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y13959; CAA74293.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). SQ SEQUENCE 317 AA; 34895 MW; E634FE7B4A8AEA3C CRC64; MPVLGSQRRL LGSLNCTPPA TFPLMLAPNR TGPQCLEVSI PNGLFLSLGL VSLVENVLVV AAIAKNSNLH SPMYYFICCL AVSDLLVSVS NVLETAVMLL LEAGALAARA AVVQQLDNVI DVLICGSMVS SLCFLGAIAV DRYISIFYAL RYHSVVTLPR AWRIIAAIWV ASILTSLLFI TYYNHTVVLL CLVGFFIAML ALMAVLYVHM LARACQHARG IARLQKRQRP IHRGFGLKGA ATLTILLGVF FLCWGPFFLH LSLIVLCPQH PTCGCIFKNF NLFLALIICN AIVDPLIYAF RSQELRKTLQ EVLQCSW // ID MSHR_TRAAU STANDARD; PRT; 317 AA. AC Q864I7; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Trachypithecus auratus (Javan langur). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Colobinae; OC Trachypithecus. OX NCBI_TaxID=222416; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 3; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205110; AAP30984.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34755 MW; D4505C3C06F5F0D9 CRC64; MPVQGSQRRL LGSLNSTPTA TPRLGLAANQ TGARCLEVSI PDGLFLSLGL VSLVENVLVV VAIARNRNLH SPMYCFICCL ALSDLLVSGS NMLETAVILL LEAGALAARA AVVQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLRR ARRVVAAIWV ASVLFSTLFI AYCDHAAVLL SLVVFFLAML VLMAVLYVHM LARACQHAQG IAQLHKRQRP AHQGVGLKGA ATLTILLGIF FLCWGPFFLH LTLIVLCPQH PTCSCIFKNF NLFLTLIICN AIIDPLIYAF RSQELRRTLK KVLLCSW // ID MSHR_SAGOE STANDARD; PRT; 317 AA. AC Q864H2; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Saguinus oedipus (Cotton-top tamarin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Callitrichidae; Saguinus. OX NCBI_TaxID=9490; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 296; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205125; AAP30999.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34850 MW; FA02F5A9AAE7E43D CRC64; MPMQGAQRKL LGSLNSTPTA TSNLGLAANH TGAPCLEVSI PDGLFLSLGL VSLVENVLVV AAVAKNRNLH SSMYCFICCL ALSDLLVSGS NMLETAVILL LETGALATRT SVVQQLHNTI NVLTCSSMLC SLCFLGAIAV DRYISIFYAL RYHSIMTLPR AQRAIAAIWV ASVLSSTLFI TYYDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAHG IIRLHKRQTP AHQGFGLRGA ATLTILLGIF FLCWGPFFLH LTLVVFCPQH LTCSCIFKNF KVFLTLIICN TIIDPLIYAF RSQELRRTLK EVLLCSW // ID MSHR_VULVU STANDARD; PRT; 317 AA. AC Q29154; P79328; DT 01-NOV-1997 (Rel. 35, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Vulpes vulpes (Red fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Vulpes. OX NCBI_TaxID=9627; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97207656; PubMed=9054949; RA Vage D.I., Lu D., Klungland J., Lien S., Adalsteinsson S., Cone R.D.; RT "A non-epistatic interaction of agouti and extension in the fox, RT Vulpes vulpes."; RL Nat. Genet. 15:311-315(1997). CC -!- FUNCTION: RECEPTOR FOR MSH (ALPHA, BETA AND GAMMA) AND ACTH. THE CC ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE CC ADENYLATE CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- POLYMORPHISM: THE COAT COLOR OF THE ALASKA SILVER FOX IS PRODUCED CC BY A CONSTITUTIVELY ACTIVE MUTANT OF THIS RECEPTOR. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X90844; CAA62349.1; -. DR PIR; T12055; T12055. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate; Polymorphism. FT DOMAIN 1 37 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 38 63 1 (POTENTIAL). FT DOMAIN 64 72 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 73 93 2 (POTENTIAL). FT DOMAIN 94 118 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 119 140 3 (POTENTIAL). FT DOMAIN 141 163 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 164 183 4 (POTENTIAL). FT DOMAIN 184 191 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 192 211 5 (POTENTIAL). FT DOMAIN 212 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 266 6 (POTENTIAL). FT DOMAIN 267 279 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 280 300 7 (POTENTIAL). FT DOMAIN 301 317 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 29 29 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT VARIANT 125 125 C -> R (IN ALLELE ALASKA SILVER (EA); FT DARKLY PIGMENTED ANIMALS; CONSTITUTIVELY FT ACTIVATED). SQ SEQUENCE 317 AA; 34869 MW; DF3A13ACA6D075C5 CRC64; MSGQGPQRRL LGSPNATSPT TPHFKLAANQ TGPRCLEVSI PNGLFLSLGL VSVVENVLVV AAIAKNRNLH SPMYYFIGCL AVSDLLVSVT NVLETAVMLL VEAGALAAQA AVVQQLDDII DVLICGSMVS SLCFLGAIAV DRYLSIFYAL RYHSIVTLPR AWRAISAIWV ASVLSSTLFI AYYNHTAVLL CLVSFFVAML VLMAVLYVHM LARARQHARG IARLRKRQHS VHQGFGLKGA ATLTILLGIF FLCWGPFFLH LSLMVLCPQH PICGCVFQNF NLFLTLIICN SIIDPFIYAF RSQELRKTLQ EVVLCSW // ID MSHR_MIOTA STANDARD; PRT; 317 AA. AC Q864K4; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Miopithecus talapoin (Talapoin) (Cercopithecus talapoin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Miopithecus. OX NCBI_TaxID=36231; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 1; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205093; AAP30967.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34764 MW; FE71B284D4E6FF1A CRC64; MPVQGSQRRL LGSLNSTPTA TPHLGLAANQ TGARCLEVSI PDGLFLSLGL VSLVENVLVV TAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLETAVTLL LEAGALAARA AVVQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR ARRAVAAIWV ASVLFSMLFI AYYDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG IARLHKRQRP AHQGFGLKGA ATLTILLGIF FLCWGPFFLH LTLIVLCPQH PTCSCIFKNF NLFLALIICN AIIDPLIYAF RSQELRRTLK EVLLCSW // ID MSHR_ALOPI STANDARD; PRT; 317 AA. AC Q864G1; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Alouatta pigra (Guatemalan howler monkey) (Mexican black howler OS monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Alouattinae; OC Alouatta. OX NCBI_TaxID=182253; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 4; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205136; AAP31010.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34728 MW; 976BE14FF98B4966 CRC64; MPMQGAQRRL LGSLNSTPTA TPNLGLAANH TGAPCLEVSI PDGLFLSLGL VSLVENVLVV AAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLEMAVILL LEAGALATRA SVVQQLQNTI DVLTCSSMLC SLCFLGAIAV DRYVSIFYAL RYHSIVTLPR ARRAIAAIWV ASVLSSTLFI AYCDHAAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG ITRLHKRQLP AHQGFGLRGA ATLTILLGIF FLCWGPFFLH LMLVVLCPQH LTCSCIFKNF KVFLTLIICN TIIDPLIYAF RSQELCRTLR EVLLCSW // ID MSHR_LEOCH STANDARD; PRT; 318 AA. AC Q864I2; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Leontopithecus chrysopygus (Gold-and-black lion tamarin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Callitrichidae; OC Leontopithecus. OX NCBI_TaxID=58710; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 2; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205115; AAP30989.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT DOMAIN 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT DOMAIN 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT DOMAIN 301 318 Cytoplasmic (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 318 AA; 35080 MW; 2BB2132178306471 CRC64; MPMQGAQRKL LGSLNSTPTA TSNLGLAANR TGAPCLELPI PNGLFLSLGL VSLVENVLVV AAIAKNRNLH SSMYCFICCL ALSDLLVSGS NMLETAVILL LEAGVLATRA SVVQQLHNTI DVLTCSSMLC SLCFLGAIAV DRYISIFYAL RYHSIMTLPR AQRAVAAIWV ASVLSSTLFI TYYDHAAVLL CLMVFFLAML VLMAVLYVHM LARARQHAQG IIRLHKRQPP AHKGFGLRGA ATLTILLGIF FLCWGPFFLC LTLVVFCPQH LTCNCIFKNF KVFLTLIICN TIIDPLIYAF RSQELRRMLK EVLGRGRW // ID NY5R_RAT STANDARD; PRT; 456 AA. AC Q63634; P70586; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (Y5 DE receptor). GN NPY5R OR NPYR5. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=96317589; PubMed=8700207; RA Gerald C., Walker M.W., Criscione L., Gustafson E.L., RA Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., RA Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., RA Taber R.I., Branchek T.A., Weinshank R.L.; RT "A receptor subtype involved in neuropeptide-Y-induced food intake."; RL Nature 382:168-171(1996). RN [2] RP SEQUENCE OF 12-456 FROM N.A. RC TISSUE=Brain; RX MEDLINE=98332165; PubMed=9669502; RA Parker E.M., Babij C.K., Balasubramaniam A., Burrier R.E., Guzzi M., RA Hamud F., Mukhopadhyay G., Rudinski M.S., Tao Z., Tice M., Xia L., RA Mullins D.E., Salisbury B.G.; RT "GR231118 (1229U91) and other analogues of the C-terminus of RT neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and RT neuropeptide Y Y4 receptor agonists."; RL Eur. J. Pharmacol. 349:97-105(1998). RN [3] RP SEQUENCE OF 12-456 FROM N.A. RC STRAIN=Sprague-Dawley; RX MEDLINE=96421636; PubMed=8824284; RA Hu Y., Bloomquist B.T., Cornfield L.J., Decarr L.B., RA Flores-Riveros J.R., Friedman L., Jiang P., Lewis-Higgins L., RA Sadlowski Y., Schaefer J., Velazquez N., McCaleb M.L.; RT "Identification of a novel hypothalamic neuropeptide Y receptor RT associated with feeding behavior."; RL J. Biol. Chem. 271:26315-26319(1996). CC -!- FUNCTION: Receptor for neuropeptide y and peptide yy. The activity CC of this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. Seems to be associated with food intake. Could CC be involved in feeding disorders. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain; hypothalamus. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Highest to tachykinins receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U56078; AAC52677.1; -. DR EMBL; AF044264; AAC15670.1; -. DR EMBL; U66274; AAC52845.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 51 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 52 73 1 (POTENTIAL). FT DOMAIN 74 85 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 86 106 2 (POTENTIAL). FT DOMAIN 107 126 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 127 148 3 (POTENTIAL). FT DOMAIN 149 168 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 169 189 4 (POTENTIAL). FT DOMAIN 190 221 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 222 243 5 (POTENTIAL). FT DOMAIN 244 378 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 379 401 6 (POTENTIAL). FT DOMAIN 402 414 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 415 438 7 (POTENTIAL). FT DOMAIN 439 456 CYTOPLASMIC (POTENTIAL). FT DISULFID 125 209 BY SIMILARITY. FT LIPID 452 452 S-palmitoyl cysteine (Potential). FT CARBOHYD 21 21 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 28 28 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 456 AA; 51715 MW; 5157ABE341BA707E CRC64; MDVLFFHQDS SMEFKLEEHF NKTFVTENNT AAARNAAFPA WEDYRGSVDD LQYFLIGLYT FVSLLGFMGN LLILMAVMKK RNQKTTVNFL IGNLAFSDIL VVLFCSPFTL TSVLLDQWMF GKAMCHIMPF LQCVSVLVST LILISIAIVR YHMIKHPISN NLTANHGYFL IATVWTLGFA ICSPLPVFHS LVELKETFGS ALLSSKYLCV ESWPSDSYRI AFTISLLLVQ YILPLVCLTV SHTSVCRSIS CGLSHKENRL EENEMINLTL QPSKKSRNQA KTPSTQKWSY SFIRKHRRRY SKKTACVLPA PAGPSQGKHL AVPENPASVR SQLSPSSKVI PGVPICFEVK PEESSDAHEM RVKRSITRIK KRSRSVFYRL TILILVFAVS WMPLHVFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLRALI HCLHMS // ID MSHR_CEBAL STANDARD; PRT; 316 AA. AC Q864G9; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Melanocyte stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin-1 receptor) (MC1-R). GN MC1R. OS Cebus albifrons (White-fronted capuchin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Cebinae; Cebus. OX NCBI_TaxID=9514; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Isolate 1; RX MEDLINE=22572539; PubMed=12687585; DOI=10.1002/ajpa.10169; RA Mundy N.I., Kelly J.; RT "Evolution of a pigmentation gene, the melanocortin-1 receptor, in RT primates."; RL Am. J. Phys. Anthropol. 121:67-80(2003). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY205128; AAP31002.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Mcrtfam_receptor. DR InterPro; IPR000761; MSH_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT DOMAIN 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT DOMAIN 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT DOMAIN 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT DOMAIN 184 191 Extracellular (Potential). FT TRANSMEM 192 210 5 (Potential). FT DOMAIN 211 239 Cytoplasmic (Potential). FT TRANSMEM 240 265 6 (Potential). FT DOMAIN 266 278 Extracellular (Potential). FT TRANSMEM 279 299 7 (Potential). FT DOMAIN 300 316 Cytoplasmic (Potential). FT LIPID 314 314 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 316 AA; 34756 MW; F4EC6E7C387559A7 CRC64; MPMQGAQRKL LGSLNSTPTA TSNLGLAANH TGAPCLEVSI PDGLFLSLGL VSLVENMLVV AAIAKNRNLH SPMYCFICCL ALSDLLVSGS NMLETAVVVL LEAGALATRA SVVQQLHNTI DVLTYSSMLC SLCFVGAIAV DRYISIFYAL RYHSIMTLPR VQRVIAAIWV ASVTSSTLFI TYYEHVVALL CLVVFLTMLV LMAVLYVHML ARACQHAQGI TRLHKRQPPA HQGFGLRGAA TLTILLGIFF LCWGPFFLHL TLVVFCPQHL TCSCIFKNFK VFLTLIICNT IIDPLIYAFR SQELCRTLKE VLLCSW // ID PAR3_RAT STANDARD; PRT; 368 AA. AC Q920E1; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor- DE like 2) (Coagulation factor II receptor-like 2). GN F2RL2 OR PAR3. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Spleen; RA Chien E.K., Marietti S., Mendoza J., Phillippe M.; RT "Cloning of the rat protease activated receptor isoforms 3 and 4."; RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for activated thrombin coupled to G proteins CC that stimulate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: A proteolytic cleavage generates a new amino terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF310076; AAL26789.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Blood coagulation. FT SIGNAL 1 21 POTENTIAL. FT PROPEP 22 37 REMOVED FOR RECEPTOR ACTIVATION (BY FT SIMILARITY). FT CHAIN 38 368 PROTEINASE ACTIVATED RECEPTOR 3. FT DOMAIN 38 93 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 94 114 1 (POTENTIAL). FT DOMAIN 115 123 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 124 144 2 (POTENTIAL). FT DOMAIN 145 166 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 167 187 3 (POTENTIAL). FT DOMAIN 188 208 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 209 229 4 (POTENTIAL). FT DOMAIN 230 257 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 258 278 5 (POTENTIAL). FT DOMAIN 279 300 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 301 321 6 (POTENTIAL). FT DOMAIN 322 338 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 339 359 7 (POTENTIAL). FT DOMAIN 360 368 CYTOPLASMIC (POTENTIAL). FT SITE 37 38 CLEAVAGE (BY THROMBIN) (BY SIMILARITY). FT DISULFID 164 243 BY SIMILARITY. FT CARBOHYD 80 80 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 368 AA; 41795 MW; CE0E94EDA3B80EF1 CRC64; MEMKVLILVG VRLLFLPTTV CQSGMKHVSD NSALTAESFN GNEHSFEEFP LSDIEGWTGA TTTIKAKCPE ESITTLHVNN ATMGYLRSSL STKVIPAIYI LVFVIGVPAN IVTLWKLSSR TKSICLVIFH TNLAIADLLF CVTLPFKIAY HLNGNDWVFG EVMCRVTTVA FYGNMYCAIL ILTCMGINRY LATVHPFTYR KLPKRNFTLL MCGVVWVMVV LYMLPLAILK QEYHLVQPGI TTCHDVHDTC ESPLPFQFYY FVSLAFFGFL IPFVVSVFCY TTLIHKLNAQ DRKWLRYIKA VLLILVIFTI CFAPTNIILI IHHANYYYSN TDSLYFMYLI ALCLGSLNSC LDPFLYFIMS KIVDQLTS // ID GP37_HUMAN STANDARD; PRT; 613 AA. AC O15354; O00348; O14768; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Probable G protein-coupled receptor GPR37 precursor (Endothelin B DE receptor-like protein-1) (ETBR-LP-1). GN GPR37. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=97480717; PubMed=9339362; RA Marazziti D., Golini E., Gallo A., Lombardi M.S., Matteoni R., RA Tocchini-Valentini G.P.; RT "Cloning of GPR37, a gene located on chromosome 7 encoding a putative RT G-protein-coupled peptide receptor, from a human frontal brain EST RT library."; RL Genomics 45:68-77(1997). RN [2] RP SEQUENCE FROM N.A. RA Donohue P.J., Shapira H., Mantey S.A., Hampton L.L., Jensen R.T., RA Battey J.F.; RT "A human gene encodes a putative G protein-coupled receptor highly RT expressed in the central nervous system."; RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=97289672; PubMed=9144577; RA Zeng Z., Su K., Kyaw H., Li Y.; RT "A novel endothelin receptor type-B-like gene enriched in the brain."; RL Biochem. Biophys. Res. Commun. 233:559-567(1997). RN [4] RP SEQUENCE FROM N.A. RA Jones K., Tin-Wollam A., Keppler D.; RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y12476; CAA73080.1; -. DR EMBL; Y12477; CAA73080.1; JOINED. DR EMBL; AF017262; AAB70008.1; -. DR EMBL; U87460; AAC51281.1; -. DR EMBL; AC004925; AAD08853.1; -. DR EMBL; BC040007; AAH40007.1; -. DR PIR; JC5501; JC5501. DR Genew; HGNC:4494; GPR37. DR MIM; 602583; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal. FT SIGNAL 1 26 POTENTIAL. FT CHAIN 27 613 PROBABLE G PROTEIN-COUPLED RECEPTOR FT GPR37. FT DOMAIN 27 265 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 266 286 1 (POTENTIAL). FT DOMAIN 287 299 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 300 320 2 (POTENTIAL). FT DOMAIN 321 335 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 336 356 3 (POTENTIAL). FT DOMAIN 357 379 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 380 400 4 (POTENTIAL). FT DOMAIN 401 443 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 444 464 5 (POTENTIAL). FT DOMAIN 465 493 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 494 514 6 (POTENTIAL). FT DOMAIN 515 531 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 532 552 7 (POTENTIAL). FT DOMAIN 553 613 CYTOPLASMIC (POTENTIAL). FT DOMAIN 563 568 POLY-CYS. FT DISULFID 334 419 BY SIMILARITY. FT CARBOHYD 36 36 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 222 222 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 239 239 N-LINKED (GLCNAC...) (POTENTIAL). FT CONFLICT 93 93 G -> D (IN REF. 3). FT CONFLICT 106 106 A -> T (IN REF. 3). FT CONFLICT 118 118 G -> V (IN REF. 3). FT CONFLICT 160 160 G -> V (IN REF. 3). FT CONFLICT 182 182 W -> C (IN REF. 3). FT CONFLICT 231 231 E -> D (IN REF. 3). FT CONFLICT 284 284 C -> S (IN REF. 2). FT CONFLICT 304 304 A -> V (IN REF. 3). FT CONFLICT 329 329 L -> V (IN REF. 3). FT CONFLICT 503 504 FC -> LG (IN REF. 3). FT CONFLICT 598 598 T -> A (IN REF. 3). SQ SEQUENCE 613 AA; 67113 MW; 5A1AB269ED63E765 CRC64; MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ RRGRDAWGPG NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR GAEASAAGPP GPPTRPPGPW RWKGARGQEP SETLGRGNPT ALQLFLQISE EEEKGPRGAG ISGRSQEQSV KTVPGASDLF YWPRRAGKLQ GSHHKPLSKT ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS TNRRVRLKNP FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF SGRAPAERCI IKISPDLPDT IYVLALTYDS ARLWWYFGCY FCLPTLFTIT CSLVTARKIR KAEKACTRGN KRQIQLESQM NCTVVALTIL YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR REMSTFASVG THC // ID MC3R_MOUSE STANDARD; PRT; 323 AA. AC P33033; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Melanocortin-3 receptor (MC3-R). GN MC3R. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94226597; PubMed=8172596; RA Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M.; RT "Molecular cloning, functional expression and pharmacological RT characterization of a mouse melanocortin receptor gene."; RL Biochem. J. 299:367-373(1994). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. This CC receptor is mediated by G proteins which activate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X74983; CAA52918.1; -. DR PIR; S43850; S43850. DR MGD; MGI:96929; Mc3r. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 38 63 1 (POTENTIAL). FT DOMAIN 64 75 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 76 100 2 (POTENTIAL). FT DOMAIN 101 118 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 119 140 3 (POTENTIAL). FT DOMAIN 141 160 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 161 181 4 (POTENTIAL). FT DOMAIN 182 186 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 187 210 5 (POTENTIAL). FT DOMAIN 211 245 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 246 268 6 (POTENTIAL). FT DOMAIN 269 277 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 278 301 7 (POTENTIAL). FT DOMAIN 302 323 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 16 16 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 28 28 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 315 315 S-palmitoyl cysteine (Potential). SQ SEQUENCE 323 AA; 35806 MW; F4B7B02FA4A87B7B CRC64; MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAI DRYVTIFYAL RYHSIMTVRK ALTLIGVIWV CCGICGVMFI IYSESKMVIV CLITMFFAMV LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA FRSLELRNTF KEILCGCNSM NLG // ID MC3R_RAT STANDARD; PRT; 323 AA. AC P32244; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Melanocortin-3 receptor (MC3-R). GN MC3R. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Fischer; TISSUE=Hypothalamus; RX MEDLINE=94022273; PubMed=8415620; RA Roselli-Rehfuss L., Mountjoy K.G., Robbins L.S., Mortrud M.T., RA Low M.J., Simerly R.B., Cone R.D.; RT "Identification of a receptor for gamma melanotropin and other RT proopiomelanocortin peptides in the hypothalamus and limbic system."; RL Proc. Natl. Acad. Sci. U.S.A. 90:8856-8860(1993). CC -!- FUNCTION: RECEPTOR FOR MSH (ALPHA, BETA AND GAMMA) AND ACTH. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X70667; CAA50005.1; -. DR PIR; A48254; S36636. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 37 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 38 63 1 (POTENTIAL). FT DOMAIN 64 75 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 76 100 2 (POTENTIAL). FT DOMAIN 101 118 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 119 140 3 (POTENTIAL). FT DOMAIN 141 160 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 161 181 4 (POTENTIAL). FT DOMAIN 182 186 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 187 210 5 (POTENTIAL). FT DOMAIN 211 245 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 246 268 6 (POTENTIAL). FT DOMAIN 269 277 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 278 301 7 (POTENTIAL). FT DOMAIN 302 323 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 16 16 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 28 28 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 315 315 S-palmitoyl cysteine (Potential). SQ SEQUENCE 323 AA; 35866 MW; F4E4985C75E70A36 CRC64; MNSSCCPSSS YPTLPNLSQH PAAPSASNRS GSGFCEQVFI KPEVFLALGI VSLMENILVI LAVVRNGNLH SPMYFFLLSL LQADMLVSLS NSLETIMIVV INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAV DRYVTIFYAL RYHSIMTVRK ALSLIVAIWV CCGICGVMFI VYSESKMVIV CLITMFFAMV LLMGTLYIHM FLFARLHVQR IAALPPADGV APQQHSCMKG AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA FRSLELRNTF KEILCGCNGM NVG // ID ETB2_HUMAN STANDARD; PRT; 481 AA. AC O60883; Q86VP7; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Endothelin B receptor-like protein-2 precursor (ETBR-LP-2) (G protein- DE coupled receptor 37 like 1). GN GPR37L1 OR ETBRLP2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=98198552; PubMed=9539149; RA Valdenaire O., Giller T., Breu V., Ardati A., Schweizer A., RA Richards J.G.; RT "A new family of orphan G protein-coupled receptors predominantly RT expressed in the brain."; RL FEBS Lett. 424:193-196(1998). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in the central nervous system. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y16280; CAA76153.1; -. DR EMBL; BC050334; AAH50334.1; -. DR Genew; HGNC:14923; GPR37L1. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0016526; F:G-protein coupled receptor activity, unknow...; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal. FT SIGNAL 1 25 Potential. FT CHAIN 26 481 Endothelin B receptor-like protein-2. FT DOMAIN 26 134 Extracellular (Potential). FT TRANSMEM 135 155 1 (Potential). FT DOMAIN 156 167 Cytoplasmic (Potential). FT TRANSMEM 168 188 2 (Potential). FT DOMAIN 189 205 Extracellular (Potential). FT TRANSMEM 206 226 3 (Potential). FT DOMAIN 227 251 Cytoplasmic (Potential). FT TRANSMEM 252 272 4 (Potential). FT DOMAIN 273 310 Extracellular (Potential). FT TRANSMEM 311 331 5 (Potential). FT DOMAIN 332 361 Cytoplasmic (Potential). FT TRANSMEM 362 382 6 (Potential). FT DOMAIN 383 398 Extracellular (Potential). FT TRANSMEM 399 419 7 (Potential). FT DOMAIN 420 481 Cytoplasmic (Potential). FT DOMAIN 430 436 Poly-Cys. FT DISULFID 203 286 By similarity. FT CARBOHYD 105 105 N-linked (GlcNAc...) (Potential). FT CONFLICT 90 91 DK -> GR (in Ref. 2). SQ SEQUENCE 481 AA; 52828 MW; 81108C94B9D1F287 CRC64; MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED EEAKGVQQYV PEEWAEYPRP IHPAGLQPTK PLVATSPNPD KDGGTPDSGQ ELRGNLTGAP GQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASEASAANG SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP C // ID DUFF_BOVIN STANDARD; PRT; 330 AA. AC Q9GLX0; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Duffy antigen/chemokine receptor. GN FY OR DARC. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RA Tournamille C., Colin Y.; RT "Bovine DARC gene."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Non-specific receptor for many chemokines (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY DUFFY OF G-PROTEIN COUPLED CC RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF109158; AAG31021.1; -. DR InterPro; IPR005384; Duffyantigen. DR PRINTS; PR01559; DUFFYANTIGEN. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 57 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 58 78 1 (POTENTIAL). FT DOMAIN 79 89 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 90 110 2 (POTENTIAL). FT DOMAIN 111 120 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 121 141 3 (POTENTIAL). FT DOMAIN 142 160 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 161 181 4 (POTENTIAL). FT DOMAIN 182 201 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 202 222 5 (POTENTIAL). FT DOMAIN 223 238 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 239 259 6 (POTENTIAL). FT DOMAIN 260 281 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 282 302 7 (POTENTIAL). FT DOMAIN 303 330 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 12 12 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 35 35 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 52 52 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 330 AA; 35472 MW; EB731B87848973EB CRC64; MGNCLYPVAD DNSTKLAIKE DFLIDFPEDY YPDYNETDVE AAAPCHSCSL LNYSSLPFFI LVSILGILAS GTILYALLRP LFRWQLYQDR STLVQLAVGS ALFSIVVPIL ARGLSGALIT SLCHLAHLVA YGSAFAQALL IGYHACLGPR LGAGQVPGLR LGVTVGLWGV AALLSLPVVL GSDTSQGLCT VTFSGEWETL RYIHAAACFA IFVLLPLGLL GTKGLKTVLG RAPCPWVDVL WVWFIFWWPQ GMTLGLDSLV RSKAIVVSTC PAQQALDMLL DVAEALAILH CVATPLLLAW VCYQATHTSP PSLPLPTTQT SHLDTLGSKS // ID DUFF_SAIBB STANDARD; PRT; 336 AA. AC Q95LF5; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Duffy antigen/chemokine receptor. GN FY OR DARC. OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Cebinae; Saimiri. OX NCBI_TaxID=39432; RN [1] RP SEQUENCE FROM N.A. RA Tournamille C., Blancher A., Le Van Kim C., Gane P., Apoil P.A., RA Nakamoto W., Cartron J.-P., Colin Y.; RT "Sequences, evolution and ligand binding properties of mammalian Duffy RT antigen/receptor for chemokines."; RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Non-specific receptor for many chemokines (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY DUFFY OF G-PROTEIN COUPLED CC RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF311918; AAL09453.1; -. DR InterPro; IPR005384; Duffyantigen. DR PRINTS; PR01559; DUFFYANTIGEN. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 63 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 64 84 1 (POTENTIAL). FT DOMAIN 85 95 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 96 116 2 (POTENTIAL). FT DOMAIN 117 126 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 127 147 3 (POTENTIAL). FT DOMAIN 148 166 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 167 187 4 (POTENTIAL). FT DOMAIN 188 207 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 208 228 5 (POTENTIAL). FT DOMAIN 229 244 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 245 265 6 (POTENTIAL). FT DOMAIN 266 287 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 288 308 7 (POTENTIAL). FT DOMAIN 309 336 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 16 16 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 27 27 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 33 33 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 58 58 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 336 AA; 35624 MW; A1336E29FE693A95 CRC64; MGNCLHQAEL SPSTENSSQL NLEDLWNFSY NGNDSFPEID YDASLAAAAP CHSCSLLNDS SLPFFILASD LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPILAPGL GNTHSSALCS LGYCVWYGSA FAQALLLGCH ASLGPKLGAG QVPGLTLGLP VGLWGATALL TLPITLASGA SDGLCTPIYS TELEALQATH AVACFAIFVL LPLGLFGAKG LKKALGMGPG PWMNILWVWF IFWWPHGLVL GLDFLVGSKL SLLPTCLAQQ VLDLLLNLAE ALAIVHCVAT PLLLALFCHQ TTRTLLPSLP LPERWSSPVD TLGSKS // ID LSHR_CALJA STANDARD; PRT; 676 AA. AC O02721; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) DE (LSH-R) (Luteinizing hormone receptor). GN LHCGR. OS Callithrix jacchus (Common marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Callitrichidae; OC Callithrix. OX NCBI_TaxID=9483; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Testis; RX MEDLINE=97307697; PubMed=9165039; RA Zhang F.-P., Rannikko A.S., Manna P.R., Fraser H.M., Huhtaniemi I.T.; RT "Cloning and functional expression of the luteinizing hormone RT receptor complementary deoxyribonucleic acid from the marmoset monkey RT testis: absence of sequences encoding exon 10 in other species."; RL Endocrinology 138:2481-2490(1997). CC -!- FUNCTION: RECEPTOR FOR LUTROPIN-CHORIOGONADOTROPIC HORMONE. CC THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH CC ACTIVATE ADENYLATE CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC FSH/LSH/TSH SUBFAMILY. CC -!- SIMILARITY: Contains 5 leucine-rich (LRR) repeats. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U80673; AAB53698.1; -. DR HSSP; P22888; 1LUT. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001611; LRR. DR InterPro; IPR000372; LRR_Nterm. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF00560; LRR; 2. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM00013; LRRNT; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Phosphorylation; Repeat; Leucine-rich repeat. FT SIGNAL 1 29 POTENTIAL. FT CHAIN 30 676 LUTROPIN-CHORIOGONADOTROPIC HORMONE FT RECEPTOR. FT DOMAIN 30 340 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 341 362 1 (POTENTIAL). FT DOMAIN 363 372 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 373 393 2 (POTENTIAL). FT DOMAIN 394 416 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 417 439 3 (POTENTIAL). FT DOMAIN 440 459 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 460 482 4 (POTENTIAL). FT DOMAIN 483 502 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 503 526 5 (POTENTIAL). FT DOMAIN 527 547 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 548 571 6 (POTENTIAL). FT DOMAIN 572 582 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 583 604 7 (POTENTIAL). FT DOMAIN 605 676 CYTOPLASMIC (POTENTIAL). FT REPEAT 52 75 LRR 1. FT REPEAT 126 151 LRR 2. FT REPEAT 153 175 LRR 3. FT REPEAT 176 200 LRR 4. FT REPEAT 225 248 LRR 5. FT DISULFID 416 491 BY SIMILARITY. FT CARBOHYD 103 103 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 178 178 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 199 199 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 676 AA; 75677 MW; FB018227641654E1 CRC64; MKQPLLALQL LKLLLLLLLP LPPLPRALRE ARCCPEPCNC TPDGALRCPG PGAGLTRLSL AYLPVKVIPS QAFRGLNEVI KIEISQSDSL ERIEANAFDN LLNLSEILIQ NTKNLIHIEP GAFTNLPRLK YLSICNTGIR KFPDVTKIFS SETNFILEIC DNLHITTIPG NAFQGMNNES ITLKLYGNGF EEVQSHAFNG TTVISLVLKE NVHLERIHNG AFRGATGPSI LDISSTKLQA LPSHGLESIQ TLIATSSYSL KKLPSREKFA NLLDATLTYP SHCCAFRNVP TKDYPAIFAE SGQSGWDYDY GFHLPKTPRC APEPDAFNPC EDIMGYDFLR VLIWLINILA IMGNMTVLFV LLTSRYKLTV PRFLMCNLSF ADFCMGLYLL LIASVDSQTK GQYYNHAIDW QTGSGCNTAG FFTVFASELS VYTLTVITLE RWHTITYAIH LDQKLRLRHA ILIMLGGWLF SSLIAMLPLV GVSNYMKVSI CFPMDVETTL SQIYILTILI LNVVAFIIIC ACYIKIYFAV RNPELMATNK DTKIAKKMAI LIFTDFTCMA PISFFAISAA FKMPLITVTN SKVLLVLFYP INSCANPFLY AIFTKTFRRD FFLLLGKFGC CKHRAELYRR KDFSAYTSNY KNGFTGSSKP SQSTLKLPAL HCQGTALLDK TCYKEY // ID OPSD_CANFA STANDARD; PRT; 348 AA. AC P32308; P79146; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Rhodopsin. GN RHO. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94266167; PubMed=8206388; RA Petersen-Jones S.M., Sohal A.K., Sargan D.R.; RT "Nucleotide sequence of the canine rod-opsin-encoding gene."; RL Gene 143:281-284(1994). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Labrador retriever; RA Kylma T.J.; RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at 495 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X71380; CAA50502.1; -. DR EMBL; Y09004; CAA70209.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor; KW Acetylation. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 348 Cytoplasmic. FT MOD_RES 1 1 N-acetylmethionine (By similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT DISULFID 110 187 By similarity. FT BINDING 296 296 Retinal chromophore. FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT MOD_RES 343 343 Phosphoserine (by RK) (By similarity). FT CONFLICT 176 176 S -> SSLLSHSPLVL (in Ref. 2). SQ SEQUENCE 348 AA; 38962 MW; BB1A007C00CA04A2 CRC64; MNGTEGPNFY VPFSNKTGVV RSPFEYPQYY LAEPWQFSML AAYMFLLIVL GFPINFLTLY VTVQHKKLRT PLNYILLNLA VADLFMVFGG FTTTLYTSLH GYFVFGPTGC NVEGFFATLG GEIALWSLVV LAIERYVVVC KPMSNFRFGE NHAIMGVAFT WVMALACAAP PLAGWSRYIP EGMQCSCGID YYTLKPEINN ESFVIYMFVV HFAIPMIVIF FCYGQLVFTV KEAAAQQQES ATTQKAEKEV TRMVIIMVIA FLICWVPYAS VAFYIFTHQG SDFGPIFMTL PAFFAKSSSI YNPVIYIMMN KQFRNCMITT LCCGKNPLGD DEASASASKT ETSQVAPA // ID OPSD_RANCA STANDARD; PRT; 354 AA. AC P51470; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Rana catesbeiana (Bull frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana. OX NCBI_TaxID=8400; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=96070607; PubMed=7584833; RA Kayada S., Hisatomi O., Tokunaga F.; RT "Cloning and expression of frog rhodopsin cDNA."; RL Comp. Biochem. Physiol. 110B:599-604(1995). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This receptor is coupled to the activation CC of phospholipase C. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at 500 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; S79840; AAB35478.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 354 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT BINDING 296 296 Retinal chromophore. FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 354 AA; 39983 MW; 9CA7D77576978479 CRC64; MNGTEGPNFY VPMSNKTGIV RSPFEYPQYY LAEPWKYSVL AAYMFLLILL GLPINFMTLY VTIQHKKLRT PLNYILLNLA FANHFMVLCG FTITMYTSLH GYFVFGQTGC YFEGFFATLG GEIALWSLVV LAIERYIVVC KPMSNFRFGE NHAMMGVAFT WIMALACAVP PLFGWSRYIP EGMQCSCGVD YYTLKPEVNN ESFVIYMFVV HFLIPLIIIS FCYGRLVCTV KEAAAQQQES ATTQKAEKEV TRMVVIMVIF FLICWVPYAY VAFYIFTHQG SEFGPIFMTV PAFFAKSSAI YNPVIYIMLN KQFRNCMITT LCCGKNPFGD EDASSAATSK TEATSVSTSQ VSPA // ID OPSD_CHELB STANDARD; PRT; 353 AA. AC Q9YGZ8; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Chelon labrosus (Thicklip grey mullet). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Mugilomorpha; Mugilidae; OC Chelon. OX NCBI_TaxID=48171; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RA Archer S.N., Hirano J.; RT "Comparative analysis of opsins in Mediterranian coastal fish."; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y18669; CAA77251.1; -. DR HSSP; P02699; 1EDV. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 353 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 353 AA; 39505 MW; 8C4B6F4847B3C632 CRC64; MNGTEGPYFY IPMVNTTGIV RSPYEYPQYY LVNPAAYAAL GAYMFLLILV GFPVNFLTLY VTLEHKKLRT PLNYILLNLA VADLFMVLGG FTTTMYTSMH GYFVLGRLGC NVEGFFATLG GEIALWSLVV LAIERWVVVC KPISNFRFSE DHAIMGLAFT WVMASACAVP PLVGWSRYIP EGMQCSCGID YYTRAEGFNN ESFVIYMFVC HFLIPLVVVF FCYGRLLCAV KEAAAAQQES ETTQRAEREV SRMVVIMVVA FLVCWCPYAG VAWYIFTHQG SEFGPLFMTF PAFFAKSSSI YNPMIYICMN KQFRHCMITT LCCGKNPFEE EEGASTTSKT EASSVSSSSV SPA // ID OPSD_ANGAN STANDARD; PRT; 352 AA. AC Q90214; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin, deep-sea form. OS Anguilla anguilla (European freshwater eel). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae; OC Anguilla. OX NCBI_TaxID=7936; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=96156843; PubMed=8587887; RA Archer S.N., Hope A., Partridge J.C.; RT "The molecular basis for the green-blue sensitivity shift in the rod RT visual pigments of the European eel."; RL Proc. R. Soc. Lond., B, Biol. Sci. 262:289-295(1995). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- DEVELOPMENTAL STAGE: When eel matures sexually and migrates back CC to deep sea breeding grounds the visual pigments in its rod CC photoreceptors change from being maximally sensitive to green CC light to being maximally sensitive to blue light. In part, this CC change in sensitivity is due to a change in the opsin component of CC the visual pigment molecule; this blue sensitive rhodopsin is CC expressed during life in bluer oceanic waters. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at around 482 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L78008; AAA99297.1; -. DR HSSP; P02699; 1EDS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic (Potential). FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular (Potential). FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic (Potential). FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular (Potential). FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic (Potential). FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular (Potential). FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 352 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 15 15 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 352 AA; 39591 MW; 7DDD368750A8F589 CRC64; MNGTEGPNFY IPMSNITGVV RSPFEYPQYY LAEPWAYTIL AAYMFTLILL GFPVNFLTLY VTIEHKKLRT PLNYILLNLA VANLFMVFGG FTTTVYTSMH GYFVFGETGC NLEGYFATLG GEISLWSLVV LAIERWVVVC KPMSNFRFGE NHAIMGLAFT WIMANSCAMP PLFGWSRYIP EGMQCSCGVD YYTLKPEVNN ESFVIYMFIV HFSVPLTIIS FCYGRLVCTV KEAAAQQQES ETTQRAEREV TRMVVIMVIA FLVCWVPYAS VAWYIFTHQG STFGPVFMTV PSFFAKSSAI YNPLIYICLN SQFRNCMITT LFCGKNPFQE EEGASTTASK TEASSVSSVS PA // ID OPSD_SARPI STANDARD; PRT; 351 AA. AC Q9YGZ0; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Sardina pilchardus (European pilchard). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Clupeomorpha; Clupeidae; OC Sardina. OX NCBI_TaxID=27697; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RA Archer S.N., Hirano J.; RT "Comparative analysis of opsins in Mediterranian coastal fish."; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y18677; CAA77259.1; -. DR HSSP; P02699; 1EDV. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT DOMAIN 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT DOMAIN 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT DOMAIN 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT DOMAIN 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT DOMAIN 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT DOMAIN 310 351 Cytoplasmic. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT BINDING 296 296 Retinal chromophore (By similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT DISULFID 110 187 By similarity. SQ SEQUENCE 351 AA; 39425 MW; AACD5D0E3924ADE3 CRC64; MNGTEGPFFY IPMSNATGLV RSPYDYPQYY LVPPWGYACL AAYMFLLILT GFPVNFLTLY VTIEHKKLRS PLNYILLNLA VADLFMVIGG FTTTMWTSLN GYFVFGRMGC NIEGFFATLG GEIALWSLVV LSMERWIVVC KPISNFRFGE NHAVMGVAFS WFMAAACAVP PLVGWSRYIP EGMQCSCGID YYTRAEGFNN ESFVIYMFVV HFTCPLTIIT FCYGRLVCTV KEAAAQQQES ETTQRAEREV TRMVIIMFVA FLACWVPYAS VAWYIFTHQG SEFGPVFMTI PAFFAKSSAV YNPVIYICLN KQFRHCMITT LCCGKNPFEE EEGSTTASKT EASSVCSVSP A // ID OPSD_SARXA STANDARD; PRT; 348 AA. AC P79914; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin (Fragment). GN RHO. OS Sargocentron xantherythrum (Hawaiian squirrelfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Beryciformes; Holocentridae; OC Sargocentron. OX NCBI_TaxID=47708; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Eye; RA Toller W.W., Moses K., McFall-Ngai M.J.; RT "Molecular phylogeny of 11 holocentrid fishes (Order Beryciformes) RT inferred from rhodopsin cDNA and cytochrome b."; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U57546; AAB39536.1; -. DR HSSP; P02699; 1BOJ. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT NON_TER 1 1 FT DOMAIN <1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT DOMAIN 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 95 2 (Potential). FT DOMAIN 96 110 Extracellular (Potential). FT TRANSMEM 111 130 3 (Potential). FT DOMAIN 131 149 Cytoplasmic (Potential). FT TRANSMEM 150 173 4 (Potential). FT DOMAIN 174 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 249 Cytoplasmic (Potential). FT TRANSMEM 250 273 6 (Potential). FT DOMAIN 274 281 Extracellular (Potential). FT TRANSMEM 282 306 7 (Potential). FT DOMAIN 307 348 Cytoplasmic (Potential). FT DISULFID 107 184 By similarity. FT BINDING 293 293 Retinal chromophore (By similarity). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential). FT LIPID 320 320 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 348 AA; 39015 MW; C314A9BA32E0BA63 CRC64; TEGPYFYVPM VNTTGIVRSP YEYPQYYLVN PAAFAILGAY MFFLIIVGFP VNFMTLYVTL EHKKLRTPLN YILLNLAVAD LFMVIGGFTT TMYTSMHGYF VLGRLGCNLE GFFATLGGMI SLWSLAVLAI ERWVVVCKPI SNFRFGENHA IMGVSLTWGM ALACTVPPLV GWSRYIPEGM QCSCGIDYYT RAEGFNNETF VLYMFCCHFT VPLTIIFFCY GRLLCAVKEA AAAQQESETT QRAEREVTRM VVIMVIGFLV CWLPYASVAW FVFTHQGSEF GPLFMTIPAF FAKSSAIYNP MIYICMNKQF RHCMITTLFC GKNPFEGEEE GASSTKTEAS SASSVSPA // ID OPSD_MYRBE STANDARD; PRT; 349 AA. AC P79798; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin (Fragment). GN RHO. OS Myripristis berndti (Bigscale soldierfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Beryciformes; Holocentridae; OC Myripristis. OX NCBI_TaxID=47700; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Eye; RA Toller W.W., Moses K., McFall-Ngai M.J.; RT "Molecular phylogeny of 11 holocentrid fishes (Order Beryciformes) RT inferred from rhodopsin cDNA and cytochrome b."; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U57538; AAB39516.1; -. DR HSSP; P02699; 1BOJ. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT NON_TER 1 1 FT DOMAIN <1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT DOMAIN 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 95 2 (Potential). FT DOMAIN 96 110 Extracellular (Potential). FT TRANSMEM 111 130 3 (Potential). FT DOMAIN 131 149 Cytoplasmic (Potential). FT TRANSMEM 150 173 4 (Potential). FT DOMAIN 174 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 249 Cytoplasmic (Potential). FT TRANSMEM 250 273 6 (Potential). FT DOMAIN 274 281 Extracellular (Potential). FT TRANSMEM 282 306 7 (Potential). FT DOMAIN 307 349 Cytoplasmic (Potential). FT DISULFID 107 184 By similarity. FT BINDING 293 293 Retinal chromophore (By similarity). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential). FT LIPID 320 320 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 349 AA; 39108 MW; E7CFB1C7B330A7F3 CRC64; TEGPYFYIPM SNATGVVRSP YEYPQYYLVY PAAFAVLGAY MFFLIIFGFP VNFLTLYVTI EHKKLRTPLN YILLNLAVAD LFMVIGGFTT TIYTSMHGYF VLGRLGCNLE GFSATLGGMI SLWSLVVLAV ERWVVVCKPM SNFRFGENHA IMGVTLTWAM GLACTVPPLV GWSRYIPEGM QCSCGIDYYT RAEGFNNESF VLYMFVCHFS FPLVVIFFCY GRLLCAVKEA AAAQQESETT QRAEREVTRM VILMVIGFLV CWLPYASVAW YIFTHQGSEF GPLFMTIPAF FAKSSAIYNP VIYICLNKQF RQCMLTTLFC GKNPFEEEEG ASSTKTEASS ASSSSVSPA // ID OPSD_SARSP STANDARD; PRT; 347 AA. AC P79903; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin (Fragment). GN RHO. OS Sargocentron spiniferum (Sabre squirrelfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Beryciformes; Holocentridae; OC Sargocentron. OX NCBI_TaxID=47712; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Eye; RA Toller W.W., Moses K., McFall-Ngai M.J.; RT "Molecular phylogeny of 11 holocentrid fishes (Order Beryciformes) RT inferred from rhodopsin cDNA and cytochrome b."; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U57544; AAB39532.1; -. DR HSSP; P02699; 1BOJ. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT NON_TER 1 1 FT DOMAIN <1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT DOMAIN 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 95 2 (Potential). FT DOMAIN 96 110 Extracellular (Potential). FT TRANSMEM 111 130 3 (Potential). FT DOMAIN 131 149 Cytoplasmic (Potential). FT TRANSMEM 150 173 4 (Potential). FT DOMAIN 174 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 249 Cytoplasmic (Potential). FT TRANSMEM 250 273 6 (Potential). FT DOMAIN 274 281 Extracellular (Potential). FT TRANSMEM 282 306 7 (Potential). FT DOMAIN 307 347 Cytoplasmic (Potential). FT DISULFID 107 184 By similarity. FT BINDING 293 293 Retinal chromophore (By similarity). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential). FT LIPID 320 320 S-palmitoyl cysteine (By similarity). SQ SEQUENCE 347 AA; 39136 MW; 091ECDA403E90FE9 CRC64; TEGPDFYIPM VNTTGVVRSP YEYPQYYLVN PAAYAVLGAY MFFLIIVGFP INFLTLYVTL EHKKLRTPLN YILLNLAVAD LFMVIGGFTT TMYSSMHGYF VLGRLGCNIE GFFATLGGMI SLWSLAVLAI ERWVVVCKPI SNFRFGENHA IMGVSLTWVM ALACTVPPLV GWSRYIPEGM QCACGIDYYT RAEGYNNESF VIYMFTFHFL FPMFIIFFCY GRLLCAVKEA AAAQQESETT QRAEREVTRM VILMVIGYLV CWLPYASVAW FIFTHKGSEF GPLFMAVPSF FAKSSSIYNP IIYICMNKQF RQCMITTLFC GKNPFEGQEE DSSTKTEASS ASSVSPA // ID OPSG_RAT STANDARD; PRT; 359 AA. AC O35476; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Green-sensitive opsin (Green cone photoreceptor pigment). GN OPN1MW OR GCP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98426163; PubMed=9751808; RA Radlwimmer F.B., Yokoyama S.; RT "Genetic analyses of the green visual pigments of rabbit (Oryctolagus RT cuniculus) and rat (Rattus norvegicus)."; RL Gene 218:103-109(1998). RN [2] RP SEQUENCE OF 43-315 FROM N.A. RX MEDLINE=98242086; PubMed=9580985; RA Yokoyama S., Radlwimmer F.B.; RT "The 'five-sites' rule and the evolution of red and green color RT vision in mammals."; RL Mol. Biol. Evol. 15:560-567(1998). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone CC photoreceptor cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: This opsin has an absorption maximum at 509 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF054246; AAC64920.1; -. DR EMBL; AF054241; AAC64920.1; JOINED. DR EMBL; AF054242; AAC64920.1; JOINED. DR EMBL; AF054243; AAC64920.1; JOINED. DR EMBL; AF054244; AAC64920.1; JOINED. DR EMBL; AF054245; AAC64920.1; JOINED. DR EMBL; AF031528; AAB86946.1; -. DR HSSP; P02699; 1FDF. DR RGD; 620978; Opn1mw. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00575; OPSINREDGRN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 47 Extracellular (Potential). FT TRANSMEM 48 72 1 (Potential). FT DOMAIN 73 84 Cytoplasmic (Potential). FT TRANSMEM 85 110 2 (Potential). FT DOMAIN 111 124 Extracellular (Potential). FT TRANSMEM 125 144 3 (Potential). FT DOMAIN 145 163 Cytoplasmic (Potential). FT TRANSMEM 164 187 4 (Potential). FT DOMAIN 188 213 Extracellular (Potential). FT TRANSMEM 214 241 5 (Potential). FT DOMAIN 242 263 Cytoplasmic (Potential). FT TRANSMEM 264 287 6 (Potential). FT DOMAIN 288 295 Extracellular (Potential). FT TRANSMEM 296 320 7 (Potential). FT DOMAIN 321 359 Cytoplasmic (Potential). FT DISULFID 121 198 Potential. FT BINDING 307 307 Retinal chromophore. FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 359 AA; 40200 MW; 08D9294EE6BE8A05 CRC64; MAQQLTGEQT LDHYEDSTQA SIFTYTNSNS TRGPFEGPNY HIAPRWVYHL TSTWMILVVI ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV CKPFGNVRFD AKLATVGIVF SWVWAAVWTA PPIFGWSRYW PYGLKTSCGP DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS LPSYFAKSAT IYNPIIYVFM NRQFRNCILQ LFGKKVDDSS ELSSTSKTEV SSVSSVSPA // ID OPSR_ASTFA STANDARD; PRT; 357 AA. AC P22332; DT 01-AUG-1991 (Rel. 19, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Red-sensitive opsin (Red cone photoreceptor pigment). GN R007. OS Astyanax fasciatus (Blind cave fish) (Astyanax mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characidae; Astyanax. OX NCBI_TaxID=7994; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93330041; PubMed=8336542; RA Yokoyama R., Yokoyama S.; RT "Paralogous origin of the red- and green-sensitive visual pigment RT genes in vertebrates."; RL Mol. Biol. Evol. 10:527-538(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Pineal gland; RX MEDLINE=91067696; PubMed=2123554; RA Yokoyama R., Yokoyama S.; RT "Convergent evolution of the red- and green-like visual pigment genes RT in fish, Astyanax fasciatus, and human."; RL Proc. Natl. Acad. Sci. U.S.A. 87:9315-9318(1990). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The color pigments are found in the cone CC photoreceptor cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M90075; AAA02766.1; -. DR EMBL; M38630; AAA62672.1; -. DR EMBL; M38625; AAA62672.1; JOINED. DR EMBL; M38626; AAA62672.1; JOINED. DR EMBL; M38627; AAA62672.1; JOINED. DR EMBL; M38628; AAA62672.1; JOINED. DR EMBL; M38629; AAA62672.1; JOINED. DR PIR; A37440; A37440. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00575; OPSINREDGRN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 49 Extracellular (Potential). FT TRANSMEM 50 74 1 (Potential). FT DOMAIN 75 86 Cytoplasmic (Potential). FT TRANSMEM 87 112 2 (Potential). FT DOMAIN 113 126 Extracellular (Potential). FT TRANSMEM 127 146 3 (Potential). FT DOMAIN 147 165 Cytoplasmic (Potential). FT TRANSMEM 166 189 4 (Potential). FT DOMAIN 190 215 Extracellular (Potential). FT TRANSMEM 216 243 5 (Potential). FT DOMAIN 244 265 Cytoplasmic (Potential). FT TRANSMEM 266 289 6 (Potential). FT DOMAIN 290 297 Extracellular (Potential). FT TRANSMEM 298 322 7 (Potential). FT DOMAIN 323 357 Cytoplasmic (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT DISULFID 123 200 Potential. FT BINDING 309 309 Retinal chromophore. SQ SEQUENCE 357 AA; 39837 MW; 41CA340478816DD4 CRC64; MGDQWGDAVF AARRRGDDTT REAAFTYTNS NNTKDPFEGP NYHIAPRWVY NLATCWMFFV VVASTVTNGL VLVASAKFKK LRHPLNWILV NLAIADLLET LLASTISVCN QFFGYFILGH PMCVFEGFTV ATCGIAGLWS LTVISWERWV VVCKPFGNVK FDGKMATAGI VFTWVWSAVW CAPPIFGWSR YWPHGLKTSC GPDVFSGSED PGVQSYMIVL MITCCFIPLG IIILCYIAVW WAIRTVAQQQ KDSESTQKAE KEVSRMVVVM IMAYCFCWGP YTFFACFAAA NPGYAFHPLA AAMPAYFAKS ATIYNPVIYV FMNRQFRVCI MQLFGKKVDD GSEVSTSKTE VSSVAPA // ID OPSV_CHICK STANDARD; PRT; 347 AA. AC P28684; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Violet-sensitive opsin (Violet cone photoreceptor pigment) (Violet DE cone opsin). OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=92335211; PubMed=1385866; RA Okano T., Kojima D., Fukada Y., Shichida Y., Yoshizawa T.; RT "Primary structures of chicken cone visual pigments: vertebrate RT rhodopsins have evolved out of cone visual pigments."; RL Proc. Natl. Acad. Sci. U.S.A. 89:5932-5936(1992). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: The color pigments are found in the cone CC photoreceptor cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Maximal absorption at 415 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M92039; AAA49141.1; -. DR PIR; C46137; C46137. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00574; OPSINBLUE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 31 Extracellular. FT TRANSMEM 32 56 1 (Potential). FT DOMAIN 57 68 Cytoplasmic. FT TRANSMEM 69 94 2 (Potential). FT DOMAIN 95 108 Extracellular. FT TRANSMEM 109 128 3 (Potential). FT DOMAIN 129 147 Cytoplasmic. FT TRANSMEM 148 171 4 (Potential). FT DOMAIN 172 197 Extracellular. FT TRANSMEM 198 225 5 (Potential). FT DOMAIN 226 247 Cytoplasmic. FT TRANSMEM 248 271 6 (Potential). FT DOMAIN 272 279 Extracellular. FT TRANSMEM 280 304 7 (Potential). FT DOMAIN 305 347 Cytoplasmic. FT CARBOHYD 12 12 N-linked (GlcNAc...) (Probable). FT DISULFID 105 182 Potential. FT BINDING 291 291 Retinal chromophore (By similarity). SQ SEQUENCE 347 AA; 38720 MW; 11B99472DFACE453 CRC64; MSSDDDFYLF TNGSVPGPWD GPQYHIAPPW AFYLQTAFMG IVFAVGTPLN AVVLWVTVRY KRLRQPLNYI LVNISASGFV SCVLSVFVVF VASARGYFVF GKRVCELEAF VGTHGGLVTG WSLAFLAFER YIVICKPFGN FRFSSRHALL VVVATWLIGV GVGLPPFFGW SRYMPEGLQC SCGPDWYTVG TKYRSEYYTW FLFIFCFIVP LSLIIFSYSQ LLSALRAVAA QQQESATTQK AEREVSRMVV VMVGSFCLCY VPYAALAMYM VNNRDHGLDL RLVTIPAFFS KSACVYNPII YCFMNKQFRA CIMETVCGKP LTDDSDASTS AQRTEVSSVS SSQVGPT // ID OPSU_BRARE STANDARD; PRT; 336 AA. AC Q9W6A9; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Ultraviolet-sensitive opsin (Ultraviolet cone photoreceptor pigment). GN OPN1SW2 OR UVOPS. OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP SEQUENCE FROM N.A., AND TISSUE SPECIFICITY. RC TISSUE=Eye; RX MEDLINE=99277479; PubMed=10349976; RA Vihtelic T.S., Doro C.J., Hyde D.R.; RT "Cloning and characterization of six zebrafish photoreceptor opsin RT cDNAs and immunolocalization of their corresponding proteins."; RL Vis. Neurosci. 16:571-585(1999). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Retinal short single cones, outer and inner CC segments. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF109373; AAD24756.1; -. DR HSSP; P02699; 1FDF. DR ZFIN; ZDB-GENE-991109-25; opn1sw2. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0009881; F:photoreceptor activity; NAS. DR GO; GO:0007601; P:visual perception; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00574; OPSINBLUE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 29 Extracellular (By similarity). FT TRANSMEM 30 54 1 (Potential). FT DOMAIN 55 66 Cytoplasmic (By similarity). FT TRANSMEM 67 91 2 (Potential). FT DOMAIN 92 106 Extracellular (By similarity). FT TRANSMEM 107 126 3 (Potential). FT DOMAIN 127 145 Cytoplasmic (By similarity). FT TRANSMEM 146 169 4 (Potential). FT DOMAIN 170 195 Extracellular (By similarity). FT TRANSMEM 196 223 5 (Potential). FT DOMAIN 224 245 Cytoplasmic (By similarity). FT TRANSMEM 246 269 6 (Potential). FT DOMAIN 270 277 Extracellular (By similarity). FT TRANSMEM 278 302 7 (Potential). FT DOMAIN 303 336 Cytoplasmic (By similarity). FT DISULFID 103 180 By similarity. FT BINDING 289 289 Retinal chromophore (By similarity). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 336 AA; 37148 MW; 2765ADF86821A18E CRC64; MDAWAVQFGN ASKVSPFEGE QYHIAPKWAF YLQAAFMGFV FIVGTPMNGI VLFVTMKYKK LRQPLNYILV NISLAGFIFD TFSVSQVSVC AARGYYSLGY TLCSMEAAMG SIAGLVTGWS LAVLAFERYV VICKPFGSFK FGQGQAVGAV VFTWIIGTAC ATPPFFGWSR YIPEGLGTAC GPDWYTKSEE YNSESYTYFL LITCFMMPMT IIIFSYSQLL GALRAVAAQQ AESESTQKAE REVSRMVVVM VGSFVLCYAP YAVTAMYFAN SDEPNKDYRL VAIPAFFSKS SSVYNPLIYA FMNKQFNACI METVFGKKID ESSEVSSKTE TSSVSA // ID OPSP_PETMA STANDARD; PRT; 444 AA. AC O42490; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Pineal opsin (P-opsin) (Pineal gland-specific opsin). OS Petromyzon marinus (Sea lamprey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Hyperoartia; OC Petromyzontiformes; Petromyzontidae; Petromyzon. OX NCBI_TaxID=7757; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98087422; PubMed=9427550; RA Yokoyama S., Zhang H.; RT "Cloning and characterization of the pineal gland-specific opsin gene RT of marine lamprey (Petromyzon marinus)."; RL Gene 202:89-93(1997). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Pineal gland. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U90671; AAC41240.1; -. DR EMBL; U90667; AAC41240.1; JOINED. DR EMBL; U90668; AAC41240.1; JOINED. DR EMBL; U90669; AAC41240.1; JOINED. DR EMBL; U90670; AAC41240.1; JOINED. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00666; PINOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 46 Extracellular. FT TRANSMEM 47 71 1 (Potential). FT DOMAIN 72 83 Cytoplasmic. FT TRANSMEM 84 108 2 (Potential). FT DOMAIN 109 123 Extracellular. FT TRANSMEM 124 143 3 (Potential). FT DOMAIN 144 162 Cytoplasmic. FT TRANSMEM 163 186 4 (Potential). FT DOMAIN 187 210 Extracellular. FT TRANSMEM 211 238 5 (Potential). FT DOMAIN 239 260 Cytoplasmic. FT TRANSMEM 261 284 6 (Potential). FT DOMAIN 285 292 Extracellular. FT TRANSMEM 293 317 7 (Potential). FT DOMAIN 318 444 Cytoplasmic. FT DISULFID 120 197 By similarity. FT BINDING 304 304 Retinal chromophore. FT CARBOHYD 25 25 N-linked (GlcNAc...) (Potential). FT LIPID 331 331 S-palmitoyl cysteine (By similarity). FT DOMAIN 409 418 Poly-Gln. SQ SEQUENCE 444 AA; 48080 MW; 4F62BDA3BA925600 CRC64; MDALQESPPS HHSLPSALPS ATGGNGTVAT MHNPFERPLE GIAPWNFTML AALMGTITAL SLGENFAVIV VTARFRQLRQ PLNYVLVNLA AADLLVSAIG GSVSFFTNIK GYFFLGVHAC VLEGFAVTYF GVVALWSLAL LAFERYFVIC RPLGNFRLQS KHAVLGLAVV WVFSLACTLP PVLGWSSYRP SMIGTTCEPN WYSGELHDHT FILMFFSTCF IFPLAVIFFS YGKLIQKLKK ASETQRGLES TRRAEQQVTR MVVVMILAFL VCWMPYATFS IVVTACPTIH LDPLLAAVPA FFSKTATVYN PVIYIFMNKQ FRDCFVQVLP CKGLKKVSAT QTAGAQDTEH TASVNTQSPG NRHNIALAAG SLRFTGAVAP SPATGVVEPT MSAAGSMGAP PNKSTAPCQQ QGQQQQQQGT PIPAITHVQP LLTHSESVSK ICPV // ID OPSD_CAMAB STANDARD; PRT; 378 AA. AC Q17292; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. OS Camponotus abdominalis (Carpenter ant). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea; OC Formicidae; Formicinae; Camponotus. OX NCBI_TaxID=47731; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=98039419; PubMed=9372150; RA Popp M.P., Grisshammer R., Hargrave P.A., Smith W.C.; RT "Ant opsins: sequences from the Saharan silver ant and the carpenter RT ant."; RL Invertebr. Neurosci. 1:323-329(1996). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U32502; AAC47083.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00578; OPSINLTRLEYE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 53 Extracellular (Potential). FT TRANSMEM 54 78 1 (Potential). FT DOMAIN 79 90 Cytoplasmic (Potential). FT TRANSMEM 91 115 2 (Potential). FT DOMAIN 116 130 Extracellular (Potential). FT TRANSMEM 131 150 3 (Potential). FT DOMAIN 151 169 Cytoplasmic (Potential). FT TRANSMEM 170 193 4 (Potential). FT DOMAIN 194 217 Extracellular (Potential). FT TRANSMEM 218 245 5 (Potential). FT DOMAIN 246 280 Cytoplasmic (Potential). FT TRANSMEM 281 304 6 (Potential). FT DOMAIN 305 311 Extracellular (Potential). FT TRANSMEM 312 336 7 (Potential). FT DOMAIN 337 378 Cytoplasmic (Potential). FT DISULFID 127 204 By similarity. FT BINDING 323 323 Retinal chromophore (By similarity). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 378 AA; 42091 MW; 99C95CB5093BA433 CRC64; MMSIASGPSH AAYTWASQGG GFGNQTVVDK VPPEMLHMVD AHWYQFPPMN PLWHALLGFV IGVLGVISVI GNGMVIYIFT TTKSLRTPSN LLVVNLAISD FLMMLCMSPA MVINCYYETW VLGPLFCELY GLAGSLFGCA SIWTMTMIAF DRYNVIVKGL SAKPMTINGA LIRILTIWFF TLAWTIAPMF GWNRYVPEGN MTACGTDYLT KDLFSRSYIL IYSIFVYFTP LFLIIYSYFF IIQAVAAHEK NMREQAKKMN VASLRSAENQ STSAECKLAK VALMTISLWF MAWTPYLVIN YSGIFETTKI SPLFTIWGSL FAKANAVYNP IVYGISHPKY RAALFQKFPS LACTTEPTGA DTMSTTTTVT EGNEKPAA // ID OPN4_MOUSE STANDARD; PRT; 521 AA. AC Q9QXZ9; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Opsin 4 (Melanopsin). GN OPN4 OR MOP OR MOPN. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=20098934; PubMed=10632589; RA Provencio I., Rodriguez I.R., Jiang G., Hayes W.P., Moreira E.F., RA Rollag M.D.; RT "A novel human opsin in the inner retina."; RL J. Neurosci. 20:600-605(2000). CC -!- FUNCTION: MAY MEDIATE REGULATION OF CIRCADIAN RHYTHMS AND ACUTE CC SUPPRESSION OF PINEAL MELATONIN. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: EYE. EXPRESSION IS RESTRICTED WITHIN THE CC GANGLION AND AMACRINE CELL LAYERS OF THE RETINA. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF147789; AAF24979.1; -. DR HSSP; P02699; 1F88. DR MGD; MGI:1353425; Opn4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; KW G-protein coupled receptor. FT DOMAIN 1 71 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 72 92 1 (POTENTIAL). FT DOMAIN 93 106 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 107 127 2 (POTENTIAL). FT DOMAIN 128 143 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 144 164 3 (POTENTIAL). FT DOMAIN 165 187 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 188 208 4 (POTENTIAL). FT DOMAIN 209 237 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 238 258 5 (POTENTIAL). FT DOMAIN 259 293 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 294 314 6 (POTENTIAL). FT DOMAIN 315 355 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 356 372 7 (POTENTIAL). FT DOMAIN 373 521 CYTOPLASMIC (POTENTIAL). FT DISULFID 142 220 POTENTIAL. FT BINDING 337 337 RETINAL CHROMOPHORE. SQ SEQUENCE 521 AA; 57231 MW; 50FD1CBB05669DA9 CRC64; MDSPSGPRVL SSLTQDPSFT TSPALQGIWN GTQNVSVRAQ LLSVSPTTSA HQAAAWVPFP TVDVPDHAHY TLGTVILLVG LTGMLGNLTV IYTFCRNRGL RTPANMFIIN LAVSDFLMSV TQAPVFFASS LYKKWLFGET GCEFYAFCGA VFGITSMITL TAIAMDRYLV ITRPLATIGR GSKRRTALVL LGVWLYALAW SLPPFFGWSA YVPEGLLTSC SWDYMTFTPQ VRAYTMLLFC FVFFLPLLII IFCYIFIFRA IRETGRACEG CGESPLRQRR QWQRLQSEWK MAKVALIVIL LFVLSWAPYS TVALVAFAGY SHILTPYMSS VPAVIAKASA IHNPIIYAIT HPKYRVAIAQ HLPCLGVLLG VSGQRSHPSL SYRSTHRSTL SSQSSDLSWI SGRKRQESLG SESEVGWTDT ETTAAWGAAQ QASGQSFCSQ NLEDGELKAS SSPQVQRSKT PKVPGPSTCR PMKGQGARPS SLRGDQKGRL AVCTGLSECP HPHTSQFPLA FLEDDVTLRH L // ID OPS2_HEMSA STANDARD; PRT; 377 AA. AC Q25158; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Compound eye opsin BCRH2. OS Hemigrapsus sanguineus (Crab). OC Eukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca; OC Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura; OC Eubrachyura; Grapsoidea; Varunidae; Hemigrapsus. OX NCBI_TaxID=40176; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Eye; RA Sakamoto K., Hisatomi O., Tokunaga F., Eguchi E.; RT "Two opsins from the compound eye of the crab Hemigrapsus RT sanguineus."; RL J. Exp. Biol. 199:441-450(1996). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This opsin produces visual pigments with CC maximal absorption in the blue-green region of the spectrum. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in all of the seven retinular cells CC (R1-R7) forming the main rhabdom in each ommatidium. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D50584; BAA09133.1; -. DR HSSP; P02699; 1L9H. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 53 Extracellular. FT TRANSMEM 54 78 1 (Potential). FT DOMAIN 79 90 Cytoplasmic. FT TRANSMEM 91 115 2 (Potential). FT DOMAIN 116 131 Extracellular. FT TRANSMEM 132 151 3 (Potential). FT DOMAIN 152 170 Cytoplasmic. FT TRANSMEM 171 194 4 (Potential). FT DOMAIN 195 218 Extracellular. FT TRANSMEM 219 246 5 (Potential). FT DOMAIN 247 281 Cytoplasmic. FT TRANSMEM 282 305 6 (Potential). FT DOMAIN 306 313 Extracellular. FT TRANSMEM 314 338 7 (Potential). FT DOMAIN 339 377 Cytoplasmic. FT DISULFID 128 205 By similarity. FT BINDING 325 325 Retinal chromophore (By similarity). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 377 AA; 42114 MW; FD6CC2E0E199A256 CRC64; MTNATGPQMA YYGAASMDFG YPEGVSIVDF VRPEIKPYVH QHWYNYPPVN PMWHYLLGVI YLFLGTVSIF GNGLVIYLFN KSAALRTPAN ILVVNLALSD LIMLTTNVPF FTYNCFSGGV WMFSPQYCEI YACLGAITGV CSIWLLCMIS FDRYNIICNG FNGPKLTTGK AVVFALISWV IAIGCALPPF FGWGNYILEG ILDSCSYDYL TQDFNTFSYN IFIFVFDYFL PAAIIVFSYV FIVKAIFAHE AAMRAQAKKM NVSTLRSNEA DAQRAEIRIA KTALVNVSLW FICWTPYALI SLKGVMGDTS GITPLVSTLP ALLAKSCSCY NPFVYAISHP KYRLAITQHL PWFCVHETET KSNDDSQSNS TVAQDKA // ID OPSD_SEPOF STANDARD; PRT; 464 AA. AC O16005; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin. GN RHO. OS Sepia officinalis (Common cuttlefish). OC Eukaryota; Metazoa; Mollusca; Cephalopoda; Coleoidea; Neocoleoidea; OC Decapodiformes; Sepioidea; Sepiidae; Sepia. OX NCBI_TaxID=6610; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Retina; RX MEDLINE=98328743; PubMed=9662500; RA Bellingham J., Morris A.G., Hunt D.M.; RT "The rhodopsin gene of the cuttlefish Sepia officinalis: sequence and RT spectral tuning."; RL J. Exp. Biol. 201:2299-2306(1998). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This receptor is coupled to the activation CC of phospholipase C (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF000947; AAC26329.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR006031; XYPPX. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF02162; XYPPX; 12. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor. FT DOMAIN 1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT DOMAIN 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 97 2 (Potential). FT DOMAIN 98 111 Extracellular (Potential). FT TRANSMEM 112 131 3 (Potential). FT DOMAIN 132 151 Cytoplasmic (Potential). FT TRANSMEM 152 175 4 (Potential). FT DOMAIN 176 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT DOMAIN 228 261 Cytoplasmic (Potential). FT TRANSMEM 262 285 6 (Potential). FT DOMAIN 286 293 Extracellular (Potential). FT TRANSMEM 294 318 7 (Potential). FT DOMAIN 319 464 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT DISULFID 108 186 By similarity. FT BINDING 305 305 Retinal chromophore (By similarity). FT LIPID 336 336 S-palmitoyl cysteine (By similarity). FT LIPID 337 337 S-palmitoyl cysteine (By similarity). FT DOMAIN 370 380 Met-rich. FT DOMAIN 381 464 Gln/Pro-rich. SQ SEQUENCE 464 AA; 51506 MW; E90CB72E07E54E33 CRC64; MGRDIPDNET WWYNPTMEVH PHWKQFNQVP DAVYYSLGIF IGICGIIGCT GNGIVIYLFT KTKSLQTPAN MFIINLAFSD FTFSLVNGFP LMTISCFIKK WVFGMAACKV YGFIGGIFGL MSIMTMSMIS IDRYNVIGRP MAASKKMSHR RAFLMIIFVW MWSTLWSIGP IFGWGAYVLE GVLCNCSFDY ITRDSATRSN IVCMYIFAFC FPILIIFFCY FNIVMAVSNH EKEMAAMAKR LNAKELRKAQ AGASAEMKLA KISIVIVTQF LLSWSPYAVV ALLAQFGPIE WVTPYAAQLP VMFAKASAIH NPLIYSVSHP KFREAIAENF PWIITCCQFD EKEVEDDKDA ETEIPATEQS GGESADAAQM KEMMAMMQKM QQQQAAYPPQ GAYPPQGGYP PQGYPPPPAQ GGYPPQGYPP PPQGYPPAQG YPPQGYPPPQ GAPPQGAPPQ AAPPQGVDNQ AYQA // ID OPSB_APIME STANDARD; PRT; 377 AA. AC P90680; O61302; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Opsin, blue-sensitive (AMBLOP). GN BLOP. OS Apis mellifera (Honeybee). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; OC Apidae; Apis. OX NCBI_TaxID=7460; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Head; RX MEDLINE=97210781; PubMed=9057845; RA Bellingham J., Wilkie S.E., Morris A.G., Bowmaker J.K., Hunt D.M.; RT "Characterisation of the ultraviolet-sensitive opsin gene in the RT honey bee, Apis mellifera."; RL Eur. J. Biochem. 243:775-781(1997). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Head; RX MEDLINE=98171548; PubMed=9502802; RA Townson S.M., Chang B.S., Salcedo E., Chadwell L.V., Pierce N.E., RA Britt S.G.; RT "Honeybee blue- and ultraviolet-sensitive opsins: cloning, RT heterologous expression in Drosophila, and physiological RT characterization."; RL J. Neurosci. 18:2412-2422(1998). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to 11-cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- MISCELLANEOUS: Maximal absorption at 439 nm. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -!- CAUTION: Was originally (Ref.1) thought to be the ultraviolet CC sensitive opsin. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U70841; AAC47455.1; -. DR EMBL; AF004168; AAC13417.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT DOMAIN 1 56 Extracellular. FT TRANSMEM 57 81 1 (Potential). FT DOMAIN 82 93 Cytoplasmic. FT TRANSMEM 94 119 2 (Potential). FT DOMAIN 120 132 Extracellular. FT TRANSMEM 133 152 3 (Potential). FT DOMAIN 153 170 Cytoplasmic. FT TRANSMEM 171 195 4 (Potential). FT DOMAIN 196 219 Extracellular. FT TRANSMEM 220 247 5 (Potential). FT DOMAIN 248 282 Cytoplasmic. FT TRANSMEM 283 306 6 (Potential). FT DOMAIN 307 314 Extracellular. FT TRANSMEM 315 339 7 (Potential). FT DOMAIN 340 377 Cytoplasmic. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT DISULFID 129 206 Potential. FT BINDING 326 326 Retinal chromophore (By similarity). FT CONFLICT 43 43 R -> H (in Ref. 2). SQ SEQUENCE 377 AA; 43015 MW; 7C066A675605E513 CRC64; MLLHNKTLAG KALAFIAEEG YVPSMREKFL GWNVPPEYSD LVRPHWRAFP APGKHFHIGL AIIYSMLLIM SLVGNCCVIW IFSTSKSLRT PSNMFIVSLA IFDIIMAFEM PMLVISSFME RMIGWEIGCD VYSVFGSISG MGQAMTNAAI AFDRYRTISC PIDGRLNSKQ AAVIIAFTWF WVTPFTVLPL LKVWGRYTTE GFLTTCSFDF LTDDEDTKVF VTCIFIWAYV IPLIFIILFY SRLLSSIRNH EKMLREQAKK MNVKSLVSNQ DKERSAEVRI AKVAFTIFFL FLLAWTPYAT VALIGVYGNR ELLTPVSTML PAVFAKTVSC IDPWIYAINH PRYRQELQKR CKWMGIHEPE TTSDATSAQT EKIKTDE // ID OPSD_PROSE STANDARD; PRT; 301 AA. AC O18486; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Rhodopsin (Fragment). GN RHO. OS Procambarus seminolae (Crayfish). OC Eukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca; OC Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea; OC Astacoidea; Cambaridae; Procambarus. OX NCBI_TaxID=61505; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97336094; PubMed=9192889; RA Crandall K.A., Hillis D.M.; RT "Rhodopsin evolution in the dark."; RL Nature 387:667-668(1997). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC Opsin subfamily. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF005388; AAB63379.1; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00578; OPSINLTRLEYE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision; KW Phosphorylation; G-protein coupled receptor. FT NON_TER 1 1 FT DOMAIN <1 18 Extracellular. FT TRANSMEM 19 43 1 (Potential). FT DOMAIN 44 55 Cytoplasmic. FT TRANSMEM 56 80 2 (Potential). FT DOMAIN 81 95 Extracellular. FT TRANSMEM 96 115 3 (Potential). FT DOMAIN 116 134 Cytoplasmic. FT TRANSMEM 135 158 4 (Potential). FT DOMAIN 159 188 Extracellular. FT TRANSMEM 189 210 5 (Potential). FT DOMAIN 211 245 Cytoplasmic. FT TRANSMEM 246 269 6 (Potential). FT DOMAIN 270 279 Extracellular. FT TRANSMEM 280 301 7 (Potential). FT DISULFID 92 169 By similarity. FT BINDING 288 288 Retinal chromophore (By similarity). FT CARBOHYD 165 165 N-linked (GlcNAc...) (Potential). FT NON_TER 301 301 SQ SEQUENCE 301 AA; 34585 MW; B68EDA41E8168B99 CRC64; LHMIHLHWYQ YPPMNPMMYP LLLIFMLFTG ILCLAGNFVT IWVFMNTKSL RTPANLLVVN LAMSDFLMMF TMFPPMMVTC YYHTWTLGPT FCQVYAFLGN LCGCASIWTM VFITFDRYNV IVKGVAGEPL STKKASLWIL TIWVLSTTWC IAPFFGWNHY VPEGNLTGCG TDYLSEDILS RSYLYVYSTW VYFLPLAITI YCYVFIIKAV AAHEKGMRDQ AKKMGIKSLR NEEAQKTSAE CRLAKIAMTT VALWFIAWTP CLLINWVGMF ARSYLSPVYT IWGYVFAKAN AVYNPIVYAI S // ID OR04_MOUSE STANDARD; PRT; 314 AA. AC Q8VFK1; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 175-3. GN MOR175-3. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073525; AAL61188.1; -. DR EMBL; AY318204; AAP71461.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 26 46 1 (POTENTIAL). FT DOMAIN 47 54 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 55 75 2 (POTENTIAL). FT DOMAIN 76 99 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 100 120 3 (POTENTIAL). FT DOMAIN 121 133 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 134 154 4 (POTENTIAL). FT DOMAIN 155 196 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 197 217 5 (POTENTIAL). FT DOMAIN 218 237 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 238 258 6 (POTENTIAL). FT DOMAIN 259 271 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 272 292 7 (POTENTIAL). FT DOMAIN 293 314 CYTOPLASMIC (POTENTIAL). FT DISULFID 97 189 BY SIMILARITY. FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 314 AA; 35458 MW; EBD1D351B54FA50F CRC64; MADENYTRIT EFIFIGLRYH PNLQVFLFLL FLLFYLVTMT GNLGMIILIR VDSRLHTPMY FFLSHLSFVD ICFSSVVAPK MLTDFFADKK AISFLGCVLQ QWFFGFFVAI ECLLLASMAY DRYVAICNPL LYSVAMSQRL CIQLVIGPYA VGFFNTMTHT TAAFRLPFCG SNIINHFFCD MSPILSLICA DIRINKLLVF IVAGAVLIVS STTIIVSYFH ILIAILRIRS AEGRRKAFST CSSHVTAVSI LYGTLFFIYV RPSAISSLDL NKVVSVFYTA VIPMLNPLIY SLRNKEVKSA MGRTVAKAKV FLKN // ID OR12_MOUSE STANDARD; PRT; 318 AA. AC Q8VFL5; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 196-2. GN MOR196-2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073509; AAL61172.1; -. DR EMBL; AY318225; AAP71477.1; ALT_INIT. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 31 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 32 52 1 (POTENTIAL). FT DOMAIN 53 60 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 61 81 2 (POTENTIAL). FT DOMAIN 82 105 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 106 126 3 (POTENTIAL). FT DOMAIN 127 139 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 140 160 4 (POTENTIAL). FT DOMAIN 161 202 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 203 223 5 (POTENTIAL). FT DOMAIN 224 243 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 244 264 6 (POTENTIAL). FT DOMAIN 265 277 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 278 298 7 (POTENTIAL). FT DOMAIN 299 318 CYTOPLASMIC (POTENTIAL). FT DISULFID 103 195 BY SIMILARITY. FT CARBOHYD 11 11 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 318 AA; 36381 MW; 7DFFF1B58DBCAB43 CRC64; MLAPKKMVRG NYSMVTEFIL LGLTDRPELQ PLLFVLFLVI YLITVGGNLG MMVLIRIDSR LHTPMYYFLA SLSCLDLCYS TNVTPKMLVN FLSEKKTISY AACLVQCYFF IAMVITEYYM LAVMAYDRYM AICNPLLYSS KMSKGVCVRL IAGPYIYGFL SGLMETMWTY RLTFCGSNII NHFYCADPPL IRLSCSDTFI KETSMFVVAG FNLSNSLFII LISYLFILIA ILRMRSAEGR RKAFSTCGSH LVAVTVFYGT LFCMYVRPPT DKSVEQSKII AVFYTFVSPM LNPIIYSLRN KDVKHAFWKL VRRNVLSK // ID O8A1_HUMAN STANDARD; PRT; 309 AA. AC Q8NGG7; Q96RC6; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8A1 (OST025). GN OR8A1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-282 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8A1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065833; BAC06052.1; -. DR EMBL; AF399512; AAK94997.1; -. DR Genew; HGNC:8469; OR8A1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT DOMAIN 217 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT DOMAIN 292 309 Cytoplasmic (Potential). FT DISULFID 97 188 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 309 AA; 34395 MW; 202DEE98B0F4EEED CRC64; MAAGNHSTVT EFILKGLTKR ADLQLPLFLL FLGIYLVTIV GNLGMITLIC LNSQLHTPMY YFLSNLSLMD LCYSSVITPK MLVNFVSEKN IISYAGCMSQ LYFFLVFVIA ECYMLTVMAY DRYVAICHPL LYNIIMSHHT CLLLVAVVYA IGLIGSTIET GLMLKLPYCE HLISHYFCDI LPLMKLSCSS TYDVEMTVFF SAGFNIIVTS LTVLVSYTFI LSSILGISTT EGRSKAFSTC SSHLAAVGMF YGSTAFMYLK PSTISSLTQE NVASVFYTTV IPMLNPLIYS LRNKEVKAAV QKTLRGKLF // ID O5T3_HUMAN STANDARD; PRT; 322 AA. AC Q8NGG3; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 5T3. GN OR5T3. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. Could also be involved in CC taste perception. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5T3". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065837; BAC06056.1; ALT_INIT. DR Genew; HGNC:15297; OR5T3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 37 Extracellular (Potential). FT TRANSMEM 38 58 1 (Potential). FT DOMAIN 59 66 Cytoplasmic (Potential). FT TRANSMEM 67 87 2 (Potential). FT DOMAIN 88 111 Extracellular (Potential). FT TRANSMEM 112 132 3 (Potential). FT DOMAIN 133 151 Cytoplasmic (Potential). FT TRANSMEM 152 172 4 (Potential). FT DOMAIN 173 208 Extracellular (Potential). FT TRANSMEM 209 229 5 (Potential). FT DOMAIN 230 249 Cytoplasmic (Potential). FT TRANSMEM 250 270 6 (Potential). FT DOMAIN 271 283 Extracellular (Potential). FT TRANSMEM 284 304 7 (Potential). FT DOMAIN 305 322 Cytoplasmic (Potential). FT DISULFID 109 201 By similarity. FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 101 101 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 322 AA; 36240 MW; 3BEC6146C34EC6E3 CRC64; MDKLSSGLDI YRNPLKNKTE VTMFILTGFT DDFELQVFLF LLFFAIYLFT LIGNLGLVVL VIEDSWLHNP MYYFLSVLSF LDACYSTVVT PKMLVNFLAK NKSISFIGCA TQMLLFVTFG TTECFLLAAM AYDHYVAIYN PLLYSVSMSP RVYVPLITAS YVAGILHATI HIVATFSLSF CGSNEIRHVF CDMPPLLAIS CSDTHTNQLL LFYFVGSIEI VTILIVLISC DFILLSILKM HSAKGRQKAF STCGSHLTGV TIYHGTILVS YMRPSSSYAS DHDIIVSIFY TIVIPKLNPI IYSLRNKEVK KAVKKMLKLV YK // ID ODD1_HUMAN STANDARD; PRT; 314 AA. AC Q8NGV5; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 13D1. GN OR13D1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR13D1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065671; BAC05896.1; ALT_INIT. DR Genew; HGNC:14695; OR13D1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 314 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 268 268 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 314 AA; 35303 MW; 76320CC745CC8EA5 CRC64; METRNYSAMT EFFLVGLSQY PELQLFLFLL CLIMYMIILL GNSLLIIITI LDSRLHTPMY FFLGNLSFLD ICYTSSSIPP MLIIFMSERK SISFIGCALQ MVVSLGLGST ECVLLAVMAY DHYVAICNPL RYSIIMNGVL YVQMAAWSWI IGCLTSLLQT VLTMMLPFCG NNVIDHITCE ILALLKLVCS DITINVLIMT VTNIVSLVIL LLLIFISYVF ILSSILRINC AEGRKKAFST CSAHSIVVIL FYGSALFMYM KPKSKNTNTS DEIIGLSYGV VSPMLNPIIY SLRNKEVKEA VKKVLSRHLH LLKM // ID O8H1_HUMAN STANDARD; PRT; 311 AA. AC Q8NGG4; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8H1. GN OR8H1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8H1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065836; BAC06055.1; -. DR Genew; HGNC:14824; OR8H1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT DOMAIN 120 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT DOMAIN 160 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT DOMAIN 217 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT DOMAIN 292 311 Cytoplasmic (Potential). FT DISULFID 96 188 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 311 AA; 35227 MW; B2E5484AE80C2BB2 CRC64; MGRRNNTNVP DFILTGLSDS EEVQMALFIL FLLIYLITML GNVGMILIIR LDLQLHTPMY FFLTHLSFID LSYSTVITPK TLANLLTSNY ISFMGCFAQM FFFVFLGAAE CFLLSSMAYD RYVAICSPLR YPVIMSKRLC CALVTGPYVI SFINSFVNVV WMSRLHFCDS NVVRHFFCDT SPILALSCMD TYDIEIMIHI LAGSTLMVSL ITISASYVSI LSTILKINST SGKQKALSTC ASHLLGVTIF YGTMIFTYLK PRKSYSLGRD QVASVFYTIV IPMLNPLIYS LRNKEVKNAL IRVMQRRQDS R // ID O8B2_HUMAN STANDARD; PRT; 313 AA. AC Q96RD0; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8B2. GN OR8B2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE OF 68-282 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8B2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF399508; AAK94993.1; -. DR Genew; HGNC:8471; OR8B2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT DOMAIN 292 313 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 313 AA; 35291 MW; A7B028D423B1D7CF CRC64; MLARNNSLVT EFILAGLTDR PEFRQPLFFL FLVIYIVTMV GNLGLITLFG LNSHLHTPMY YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR LFFFLFFVIS ECYMLTSMAY DRYVAICNPL LYKVTMSHQV CSMLTFAAYI MGLAGATAHT GCMLRLTFCS ANIINHYLCD ILPLLQLSCT STYVNEVVVL IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST CSSHVIALSL FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL RKALIKIQRR NIF // ID O1L4_HUMAN STANDARD; PRT; 311 AA. AC Q8NGR5; Q96R81; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 1L4 (Olfactory receptor 9-E) (OR9-E) (OST046). GN OR1L4 OR OR1L5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 69-284 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR1L4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065724; BAC05945.1; -. DR EMBL; AF399562; AAK95047.1; -. DR Genew; HGNC:8216; OR1L4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 26 Extracellular (Potential). FT TRANSMEM 27 50 1 (Potential). FT DOMAIN 51 58 Cytoplasmic (Potential). FT TRANSMEM 59 80 2 (Potential). FT DOMAIN 81 101 Extracellular (Potential). FT TRANSMEM 102 121 3 (Potential). FT DOMAIN 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 159 4 (Potential). FT DOMAIN 160 197 Extracellular (Potential). FT TRANSMEM 198 220 5 (Potential). FT DOMAIN 221 237 Cytoplasmic (Potential). FT TRANSMEM 238 260 6 (Potential). FT DOMAIN 261 273 Extracellular (Potential). FT TRANSMEM 274 293 7 (Potential). FT DOMAIN 294 311 Cytoplasmic (Potential). FT DISULFID 98 190 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CONFLICT 234 234 G -> R (in Ref. 2). SQ SEQUENCE 311 AA; 35277 MW; 2CF7C78F0D435399 CRC64; METKNYSSST SGFILLGLSS NPKLQKPLFA IFLIMYLLTA VGNVLIILAI YSDPRLHTPM YFFLSNLSFM DICFTTVIVP KMLVNFLSET KIISYVGCLI QMYFFMAFGN TDSYLLASMA IDRLVAICNP LHYDVVMKPW HCLLMLLGSC SISHLHSLFR VLLMSRLSFC ASHIIKHFFC DTQPVLKLSC SDTSSSQMVV MTETLAVIVT PFLCTIFSYL QIIVTVLRIP SAAGKWKAFS TCGSHLTVVV LFYGSVIYVY FRPLSMYSVM KGRVATVMYT VVTPMLNPFI YSLRNKDMKR GLKKLRHRIY S // ID O5DI_HUMAN STANDARD; PRT; 313 AA. AC Q8NGL1; Q96RB3; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 5D18. GN OR5D18. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 69-284 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5D18". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065781; BAC06001.1; -. DR EMBL; AF399525; AAK95010.1; -. DR Genew; HGNC:15285; OR5D18. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 26 Extracellular (Potential). FT TRANSMEM 27 47 1 (Potential). FT DOMAIN 48 55 Cytoplasmic (Potential). FT TRANSMEM 56 76 2 (Potential). FT DOMAIN 77 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT DOMAIN 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 161 4 (Potential). FT DOMAIN 162 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 293 7 (Potential). FT DOMAIN 294 313 Cytoplasmic (Potential). FT DISULFID 98 190 By similarity. FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CONFLICT 136 136 N -> D (in Ref. 2). SQ SEQUENCE 313 AA; 35348 MW; 97C8EF3B0A6F259A CRC64; MLLTDRNTSG TTFTLLGFSD YPELQVPLFL VFLAIYNVTV LGNIGLIVII KINPKLHTPM YFFLSQLSFV DFCYSSIIAP KMLVNLVVKD RTISFLGCVV QFFFFCTFVV TESFLLAVMA YDRFVAICNP LLYTVNMSQK LCVLLVVGSY AWGVSCSLEL TCSALKLCFH GFNTINHFFC EFSSLLSLSC SDTYINQWLL FFLATFNEIS TLLIVLTSYA FIVVTILKMR SVSGRRKAFS TCASHLTAIT IFHGTILFLY CVPNSKNSRH TVKVASVFYT VVIPMLNPLI YSLRNKDVKD TVTEILDTKV FSY // ID OR27_MOUSE STANDARD; PRT; 315 AA. AC Q8VG05; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 204-12. GN MOR204-12. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073360; AAL61023.1; -. DR EMBL; AY317591; AAP70987.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 49 1 (POTENTIAL). FT DOMAIN 50 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 78 2 (POTENTIAL). FT DOMAIN 79 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 123 3 (POTENTIAL). FT DOMAIN 124 136 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 137 157 4 (POTENTIAL). FT DOMAIN 158 200 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 201 221 5 (POTENTIAL). FT DOMAIN 222 241 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 242 262 6 (POTENTIAL). FT DOMAIN 263 275 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 276 296 7 (POTENTIAL). FT DOMAIN 297 315 CYTOPLASMIC (POTENTIAL). FT DISULFID 100 193 BY SIMILARITY. FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 315 AA; 34774 MW; C775A89EC7674E0A CRC64; MAFLQDGNHT AVTEFILLGL TDDPVLRVVL FTIILCIYLV TVFGNLSTIL LIRVSSQLHH PMYFFLSHLA SVDIGISSSV TPSMLVNFLL ERSTISYLGC GIQLGSADFI ASVECFLLAA MAYDRFMAVC NPLLYSTKMS TQVCVQLVVG SYIGGFLNAS LIVTVYFFSF LFCGPNRIDH FFCDFAPLAE LSCSDVSVSV LIISFSAGSV TMITVFVIVI SYSYILITIL KMHSTEGRHK AFSTCTSHLT AVTLYYGTIT FIYVMPKSSF STDQNKVVSV FYMVMIPMLN PLIYSLSNNE IKGALKRQLG MKTLS // ID OR30_MOUSE STANDARD; PRT; 314 AA. AC Q8VG02; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 204-15. GN MOR204-15. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073363; AAL61026.1; -. DR EMBL; AY317596; AAP70992.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 29 49 1 (POTENTIAL). FT DOMAIN 50 57 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 58 78 2 (POTENTIAL). FT DOMAIN 79 102 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 103 123 3 (POTENTIAL). FT DOMAIN 124 136 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 137 157 4 (POTENTIAL). FT DOMAIN 158 199 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 200 220 5 (POTENTIAL). FT DOMAIN 221 240 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 241 261 6 (POTENTIAL). FT DOMAIN 262 274 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 275 295 7 (POTENTIAL). FT DOMAIN 296 314 CYTOPLASMIC (POTENTIAL). FT DISULFID 100 192 BY SIMILARITY. FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 314 AA; 35124 MW; 6D55A7B1EB41689C CRC64; MAFLDNGNHT AVTEFILLGL TDDPFLRIVL FSIILCIYLV TVFGNLSTIL LIRVSSQLHH PMYFFLSHLA TVDLGISSSV TPSMLVNFLA ERSTISYLGC GIQLSSAALF GTLECFLLAV MAYDRFMAIC NPLLYSTKLS TRFCIQLVVG SYIGAFLNDS CYILSFAFFL FCGPNKVDHF FCDLSPMMEL SCSDASVSGV VISFTAGSIT MTTLIVIVIS YFYILITILK MRSTEGRQKA FSTCTSHLTA VTLYYGTIIF IYVMPKSTYS RDQNKVVSLF YMVVIPMLNP LIYSLRNNEI KGALKKQFYR KTLL // ID O8I2_HUMAN STANDARD; PRT; 310 AA. AC Q8N0Y5; Q96RC5; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8I2. GN OR8I2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-282 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8I2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065656; BAC05882.1; -. DR EMBL; AB065844; BAC06062.1; -. DR EMBL; AF399513; AAK94998.1; -. DR Genew; HGNC:15310; OR8I2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT DOMAIN 217 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT DOMAIN 292 310 Cytoplasmic (Potential). FT DISULFID 97 188 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 310 AA; 34661 MW; BF92BD882CFD7263 CRC64; MAGNNFTEVT VFILSGFANH PELQVSLFLM FLFIYLFTVL GNLGLITLIR MDSQLHTPMY FFLSNLAFID IFYSSTVTPK ALVNFQSNRR SISFVGCFVQ MYFFVGLVCC ECFLLGSMAY NRYIAICNPL LYSVVMSQKV SNWLGVMPYV IGFTSSLISV WVISSLAFCD SSINHFFCDT TALLALSCVD TFGTEMVSFV LAGFTLLSSL LIITVTYIII ISAILRIQSA AGRQKAFSTC ASHLMAVTIF YGSLIFTYLQ PDNTSSLTQA QVASVFYTIV IPMLNPLIYS LRNKDVKNAL LRVIHRKLFP // ID ODC4_HUMAN STANDARD; PRT; 318 AA. AC Q8NGS5; Q96R41; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 13C4. GN OR13C4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-289 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR13C4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065714; BAC05935.1; -. DR EMBL; AF399602; AAK95087.1; -. DR Genew; HGNC:14722; OR13C4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 277 Extracellular (Potential). FT TRANSMEM 278 298 7 (Potential). FT DOMAIN 299 318 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 318 AA; 35575 MW; A2E9E00E9D2F818B CRC64; MDKINQTFVR EFILLGLSGY PKLEIIFFAL ILVMYVVILI GNGVLIIASI LDSRLHMPMY FFLGNLSFLD ICYTTSSIPS TLVSLISKKR NISFSGCAVQ MFFGFAMGST ECFLLGMMAF DRYVAICNPL RYPIIMNKVV YVLLTSVSWL SGGINSTVQT SLAMRWPFCG NNIINHFLCE ILAVLKLACS DISVNIVTLA VSNIAFLVLP LLVIFFSYMF ILYTILRTNS ATGRHKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLLGK DNLQATEGLV SMFYGVVTPM LNPIIYSLRN KDVKAAIKYL LSRKAINQ // ID OLF0_RAT STANDARD; PRT; 310 AA. AC P23269; DT 01-NOV-1991 (Rel. 20, Created) DT 01-NOV-1991 (Rel. 20, Last sequence update) DT 01-JUL-1993 (Rel. 26, Last annotation update) DE Olfactory receptor-like protein I3. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91191556; PubMed=1840504; RA Buck L., Axel R.; RT "A novel multigene family may encode odorant receptors: a molecular RT basis for odor recognition."; RL Cell 65:175-187(1991). CC -!- FUNCTION: PUTATIVE ODORANT RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: OLFACTORY EPITHELIUM. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M64385; AAA41748.1; -. DR PIR; E23701; E23701. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 23 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 24 48 1 (POTENTIAL). FT DOMAIN 49 55 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 56 77 2 (POTENTIAL). FT DOMAIN 78 98 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 99 118 3 (POTENTIAL). FT DOMAIN 119 137 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 138 156 4 (POTENTIAL). FT DOMAIN 157 194 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 195 217 5 (POTENTIAL). FT DOMAIN 218 234 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 235 258 6 (POTENTIAL). FT DOMAIN 259 270 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 271 290 7 (POTENTIAL). FT DOMAIN 291 310 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 3 3 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 95 187 BY SIMILARITY. SQ SEQUENCE 310 AA; 35247 MW; 9688233890205B19 CRC64; MNNQTFITQF LLLGLPIPEE HQHLFYALFL VMYLTTILGN LLIIVLVQLD SQLHTPMYLF LSNLSFSDLC FSSVTMPKLL QNMRSQDTSI PYGGCLAQTY FFMVFGDMES FLLVAMAYDR YVAICFPLHY TSIMSPKLCT CLVLLLWMLT TSHAMMHTLL AARLSFCENN VVLNFFCDLF VLLKLACSDT YINELMIFIM STLLIIIPFF LIVMSYARII SSILKVPSTQ GICKVFSTCG SHLSVVSLFY GTIIGLYLCP AGNNSTVKEM VMAMMYTVVT PMLNPFIYSL RNRDMKRALI RVICSMKITL // ID OR19_MOUSE STANDARD; PRT; 310 AA. AC Q8VG44; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Putative olfactory receptor 204-4. GN MOR204-4. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21676863; PubMed=11802173; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21864068; PubMed=11875048; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human RT olfactory receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [3] RP ERRATUM. RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RL Hum. Mol. Genet. 11:1683-1683(2002). CC -!- FUNCTION: Potential odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AY073319; AAL60982.1; -. DR EMBL; AY317581; AAP70978.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 26 46 1 (POTENTIAL). FT DOMAIN 47 54 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 55 75 2 (POTENTIAL). FT DOMAIN 76 99 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 100 120 3 (POTENTIAL). FT DOMAIN 121 133 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 134 154 4 (POTENTIAL). FT DOMAIN 155 196 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 197 217 5 (POTENTIAL). FT DOMAIN 218 237 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 238 258 6 (POTENTIAL). FT DOMAIN 259 271 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 272 292 7 (POTENTIAL). FT DOMAIN 293 310 CYTOPLASMIC (POTENTIAL). FT DISULFID 97 189 BY SIMILARITY. FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 265 265 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 310 AA; 34186 MW; 307AE78DF6A736D1 CRC64; MEAENHTTVA ELIILGLTED PKLCIVFFVI FLGVYIVTLV GNISIITLIR ISSQLHTPMY LFLSHLAFVD ILYSTSVSVI MHMELLGHGL ALPVAACAAQ LCITVSFGSA ECFLLAAMAY DRYVAICSPL LYSTLMSPRV CFLLLGMSYV GGCMNGWTFT GCLLSLSFCG PNQIDHFFCD FSPLLKLSCS DVSIIGIIPS ISSGSIIVVT VFVIAVSYIY ILITILNMRS TEGRHKAFST CTSHLTAVTL YYGTITFIYV MPKSNYSTEQ NKVLSVFYTV VIPMLNPLIY SLRNRDVKEA LRKATVRVYS // ID O2D2_HUMAN STANDARD; PRT; 308 AA. AC Q9H210; O95224; Q96R52; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Olfactory receptor 2D2 (Olfactory receptor 11-610) (OR11-610) (HB2). GN OR2D2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21310002; PubMed=11416212; RA Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., RA Rowen L., Evans G., Axel R., Hood L., Trask B.J.; RT "Genomic analysis of orthologous mouse and human olfactory receptor RT loci."; RL Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001). RN [2] RP SEQUENCE OF 67-283 FROM N.A. RX MEDLINE=99005533; PubMed=9787077; RA Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., RA Evans G.A.; RT "Organization and evolution of olfactory receptor genes on human RT chromosome 11."; RL Genomics 53:56-68(1998). RN [3] RP SEQUENCE OF 68-281 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2D2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF321237; AAG45204.1; -. DR EMBL; AF065876; AAC70020.1; -. DR EMBL; AF399591; AAK95076.1; -. DR Genew; HGNC:8244; OR2D2. DR MIM; 608494; -. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004984; F:olfactory receptor activity; NAS. DR GO; GO:0007608; P:perception of smell; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 270 Extracellular (Potential). FT TRANSMEM 271 290 7 (Potential). FT DOMAIN 291 308 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CONFLICT 134 134 D -> N (in Ref. 1). SQ SEQUENCE 308 AA; 34130 MW; 0651A5973426082A CRC64; MRQINQTQVT EFLLLGLSDG PHTEQLLFIV LLGVYLVTVL GNLLLISLVH VDSQLHTPMY FFLCNLSLAD LCFSTNIVPQ ALVHLLSRKK VIAFTLCAAR LLFFLIFGCT QCALLAVMSY DRYVAICNPL RYPDIMTWKV CVQLATGSWT SGILVSVVDT TFTLRLPYRG SNSIAHFFCE APALLILAST DTHASEMAIF LTGVVILLIP VFLILVSYGR IIVTVVKMKS TVGSLKAFST CGSHLMVVIL FYGSAIITYM TPKSSKQQEK SVSVFYAIVT PMLNPLIYSL RNKDVKAALR KVATRNFP // ID O7AA_HUMAN STANDARD; PRT; 309 AA. AC O76100; Q96R97; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 7A10 (OST027). GN OR7A10. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Sperm; RA Lamerdin J.E., McCready P.M., Skowronski E., Adamson A.W., RA Burkhart-Schultz K.J., Gordon L., Kyle A., Ramirez M., Stilwagen S., RA Phan H., Velasco N., Do L., Regala W., Terry A., Garnes J., RA Danganan L., Poundstone P., Christensen M., Georgescu A., Avila J., RA Liu S., Attix C., Andreise T., Trankheim M., Amico-Keller G., RA Coefield J., Duarte S., Lucas S., Bruce R., Thomas P., Quan G., RA Kronmiller B., Arellano A., Montgomery M., Ow D., Nolan M., Trong S., RA Kobayashi A., Olsen A.S., Carrano A.V.; RT "Sequence analysis of an ~1.5 Mb olfactory receptor (OLFR) cluster in RT 19q13.1."; RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-283 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR7A10". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AC005255; AAC25627.1; -. DR EMBL; AF399542; AAK95027.1; -. DR Genew; HGNC:8356; OR7A10. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 309 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CONFLICT 70 70 D -> G (in Ref. 2). SQ SEQUENCE 309 AA; 34406 MW; 8761B3C97FE3ADB1 CRC64; MKSWNNTIIL EFLLLGISEE PELQAFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY FFLSNLSFVD ICFVSTTVPK MLVNIQTHNK VITYAGCITQ MCFFLLFVGL DNFLLTVMAY DRFVAICHPL HYMVIMNPQL CGLLVLASWI MSVLNSMLQS LMVLPLPFCT HMEIPHFFCE INQVVHLACS DTFLNDIVMY FAVALLGGGP LTGILYSYSK IVSSIRAISS AQGKYKAFST CASHLSVVSL FYGTCLGVYL SSAATHNSHT GAAASVMYTV VTPMLNPFIY SLRNKHIKGA MKTFFRGKQ // ID O7AH_HUMAN STANDARD; PRT; 309 AA. AC O14581; Q96R98; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 7A17. GN OR7A17. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Lamerdin J.E., McCready P.M., Adamson A.W., Burkhart-Schultz K., RA Garcia E., Kyle A., Ramirez M., Stilwagen S., Garnes J., Danganan L., RA Bruce R., Quan G., Montgomery M., Ow D., Kobayashi A., Olsen A.O., RA Carrano A.V.; RT "Sequence analysis of an olfactory receptor (OLFR) cluster in RT 19p13.1."; RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-283 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR7A17". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AC002988; AAB82060.1; -. DR EMBL; AF399541; AAK95026.1; -. DR Genew; HGNC:8363; OR7A17. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 309 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 309 AA; 34013 MW; 7D3CED8A480C13D0 CRC64; MEPENDTGIS EFVLLGLSEE PELQPFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY FFLSNLSFAD ICFISTTIPK MLINIQTQSR VITYAGCITQ MCFFVLFGGL DSLLLAVMAY DRFVAICHPL HYTVIMNPRL CGLLVLASWM IAALNSLSQS LMVLWLSFCT DLEIPHFFCE LNQVIHLACS DTFLNDMGMY FAAGLLAGGP LVGILCSYSK IVSSIRAISS AQGKYKAFST CASHLSVVSL FCCTGLGVYL TSAATHNSHT SATASVMYTV ATPMLNPFIY SLRNKDIKRA LKMSFRGKQ // ID O1FC_HUMAN STANDARD; PRT; 337 AA. AC Q8NHA8; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 1F12 (Hs6M1-35P). GN OR1F12. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR1F12". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065468; BAC05727.1; -. DR Genew; HGNC:13964; OR1F12. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 196 Extracellular (Potential). FT TRANSMEM 197 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 292 7 (Potential). FT DOMAIN 293 337 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 265 265 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 337 AA; 36932 MW; C44062866561B532 CRC64; MEGKNQTNIS EFLLLGFSSW QQQQVLLFAL FLCLYLTGLF GNLLILLAIG SDHCLHTPMY FFLANLSLVD LCLPSATVPK MLLNIQTQTQ TISYPGCLAQ MYFCMMFANM DNFLLTVMAY DRYVAICHPL HYSTIMALRL CASLVAAPWV IAILNPLLHT LMMAHLHFCS DNVIHHFFCD INSLLPLSCS DTSLNQLSVL ATVGLIFVVP SVCILVSYIL IVSAVMKVPS AQGKLKAFST CGSHLALVIL FYGAITGVYM SPLSNHSTEK DSAASVIFMV VAPVLNPFIY SLRNNELKGT LKKTLSRPGA VAHACNPSTL GGRGGWIMRS GDRDHPG // ID O8J3_HUMAN STANDARD; PRT; 315 AA. AC Q8NGG0; Q96RC2; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8J3. GN OR8J3. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-283 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8J3". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065841; BAC06060.1; -. DR EMBL; AF399516; AAK95001.1; -. DR Genew; HGNC:15312; OR8J3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 315 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 265 265 N-linked (GlcNAc...) (Potential). FT CONFLICT 208 208 V -> F (in Ref. 2). SQ SEQUENCE 315 AA; 35481 MW; EBC2E1724FCC4D2E CRC64; MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYVLTMA GNLGIITLTS VDSRLQNPMY FFLRHLAIIN LGNSTVIAPK MLMNFLVKKK TTSFYECATQ LGGFLFFIVS EVMMLAVMAY DRYVAICNPL LYMVVVSRRL CLLLVSLTYL YGFSTAIVVS PCIFSVSYCS SNIINHFYCD IAPLLALSCS DTYIPETIVF ISAATNLVFS MITVLVSYFN IVLSILRIRS PEGRKKAFST CASHMIAVTV FYGTMLFMYL QPQTNHSLDT DKMASVFYTL VIPMLNPLIY SLRNNDVNVA LKKFMENPCY SFKSM // ID ODC3_HUMAN STANDARD; PRT; 317 AA. AC Q8NGS6; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 13C3. GN OR13C3. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR13C3". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065713; BAC05934.1; -. DR Genew; HGNC:14704; OR13C3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 277 Extracellular (Potential). FT TRANSMEM 278 298 7 (Potential). FT DOMAIN 299 317 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 35313 MW; 1A2332552FD8A985 CRC64; MGEINQTLVS EFLLLGLSGY PKIEIVYFAL ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD ICYTSSSVPS TLVSLISKKR NISFSGCAVQ MFFGFAMGST ECLLLGMMAF DRYVAICNPL RYPIILSKVA YVLMASVSWL SGGINSAVQT LLAMRLPFCG NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP LMVIFFSYMF ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH // ID O1I1_HUMAN STANDARD; PRT; 355 AA. AC O60431; Q96R92; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 1I1 (Olfactory receptor 19-20) (OR19-20). GN OR1I1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Lamerdin J.E., McCready P.M., Skowronski E., Adamson A.W., RA Burkhart-Schultz K., Gordon L., Kyle A., Ramirez M., Stilwagen S., RA Phan H., Velasco N., Do L., Regala W., Terry A., Garnes J., RA Danganan L., Poundstone P., Christensen M., Georgescu A., Avila J., RA Liu S., Attix C., Andreise T., Trankheim M., Amico-Keller G., RA Coefield J., Duarte S., Lucas S., Bruce R., Thomas P., Quan G., RA Kronmiller B., Arellano A., Montgomery M., Ow D., Nolan M., Trong S., RA Kobayashi A., Olsen A.S., Carrano A.V.; RT "Sequence analysis of an ~1.5 Mb olfactory receptor (OLFR) cluster in RT 19p13.1."; RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-283 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR1I1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AC004794; AAC18915.1; -. DR EMBL; AF399548; AAK95033.1; -. DR Genew; HGNC:8207; OR1I1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Multigene family; KW Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 292 7 (Potential). FT DOMAIN 293 355 Cytoplasmic (Potential). SQ SEQUENCE 355 AA; 39297 MW; 0C210102C186E413 CRC64; MEPEKQTEIS EFFLQGLSEK PEHQTLLFTM FLSTYLVTII GNALIILAII TDSHLHTPMY FFLFNLSLVD TLLSSTTVPK MLANIQAQSR AIPFVGCLTQ MYAFHLFGTM DSFLLAVMAI DRFVAIVHPQ RYLVLMCSPV CGLLLGASWM ITNLQSLIHT CLMAQLTFCA GSEISHFFCD LMPLLKLSGS DTHTNELVIF AFGIVVGTSP FSCILLSYIR IFWTVFKIPS TRGKWKAFST CGLHLTVVSL SYGTIFAVYL QPTSPSSSQK DKAAALMCGV FIPMLNPFIY SIRNKDMKAA LGKLIGKVAV PCPRPEQLLD VYHVPGSLLA ARDTEMHPIP YPGGVQSLAG NRDME // ID OLF7_RAT STANDARD; PRT; 327 AA. AC P23270; DT 01-NOV-1991 (Rel. 20, Created) DT 01-NOV-1991 (Rel. 20, Last sequence update) DT 01-JUL-1993 (Rel. 26, Last annotation update) DE Olfactory receptor-like protein I7. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91191556; PubMed=1840504; RA Buck L., Axel R.; RT "A novel multigene family may encode odorant receptors: a molecular RT basis for odor recognition."; RL Cell 65:175-187(1991). CC -!- FUNCTION: PUTATIVE ODORANT RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: OLFACTORY EPITHELIUM. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M64386; AAA41749.1; -. DR PIR; F23701; F23701. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 26 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 27 50 1 (POTENTIAL). FT DOMAIN 51 58 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 59 80 2 (POTENTIAL). FT DOMAIN 81 104 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 105 125 3 (POTENTIAL). FT DOMAIN 126 144 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 145 163 4 (POTENTIAL). FT DOMAIN 164 201 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 202 224 5 (POTENTIAL). FT DOMAIN 225 241 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 242 265 6 (POTENTIAL). FT DOMAIN 266 277 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 278 297 7 (POTENTIAL). FT DOMAIN 298 327 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 102 194 BY SIMILARITY. SQ SEQUENCE 327 AA; 36265 MW; 85B63DE9961621D9 CRC64; MERRNHSGRV SEFVLLGFPA PAPLRVLLFF LSLLXYVLVL TENMLIIIAI RNHPTLHKPM YFFLANMSFL EIWYVTVTIP KMLAGFIGSK ENHGQLISFE ACMTQLYFFL GLGCTECVLL AVMAYDRYVA ICHPLHYPVI VSSRLCVQMA AGSWAGGFGI SMVKVFLISR LSYCGPNTIN HFFCDVSPLL NLSCTDMSTA ELTDFVLAIF ILLGPLSVTG ASYMAITGAV MRIPSAAGRH KAFSTCASHL TVVIIFYAAS IFIYARPKAL SAFDTNKLVS VLYAVIVPLF NPIIYCLRNQ DVKRALRRTL HLAQDQEANT NKGSKIG // ID O8K5_HUMAN STANDARD; PRT; 307 AA. AC Q8NH50; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 8K5. GN OR8K5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8K5". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065542; BAC05787.1; -. DR Genew; HGNC:15315; OR8K5. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 217 5 (Potential). FT DOMAIN 218 237 Cytoplasmic (Potential). FT TRANSMEM 238 258 6 (Potential). FT DOMAIN 259 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 307 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 263 263 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 307 AA; 35190 MW; AC636BBB0D94ED18 CRC64; MGQHNLTVLT EFILMELTRR PELQIPLFGV FLVIYLITVV GNLTMIILTK LDSHLHTPMY FSIRHLAFVD LGNSTVICPK VLANFVVDRN TISYYACAAQ LAFFLMFIIS EFFILSAMAY DRYVAICNPL LYYVIMSQRL CHVLVGIQYL YSTFQALMFT IKIFTLTFCG SNVISHFYCD DVPLLPMLCS NAQEIELLSI LFSVFNLISS FLIVLVSYML ILLAICQMHS AEGRKKAFST CGSHLTVVVV FYGSLLFMYM QPNSTHFFDT DKMASVFYTL VIPMLNPLIY SLRNEEVKNA FYKLFEN // ID OAH1_HUMAN STANDARD; PRT; 318 AA. AC Q9Y4A9; Q96R59; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 10H1. GN OR10H1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Lamerdin J.E., McCready P.M., Skowronski E., Adamson A.W., RA Burkhart-Schultz K., Gordon L., Kyle A., Ramirez M., Stilwagen S., RA Phan H., Velasco N., Garnes J., Danganan L., Poundstone P., RA Christensen M., Georgescu A., Avila J., Liu S., Attix C., Andreise T., RA Trankheim M., Amico-Keller G., Coefield J., Duarte S., Lucas S., RA Bruce R., Thomas P., Quan G., Kronmiller B., Arellano A., RA Montgomery M., Ow D., Nolan M., Trong S., Kobayashi A., Olsen A.O., RA Carrano A.V.; RT "Sequence analysis of a 1.5 Mb OLFR-rich region in 19p13.1."; RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-284 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10H1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AC004510; AAC08454.1; -. DR EMBL; AF399584; AAK95069.1; -. DR Genew; HGNC:8172; OR10H1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 293 7 (Potential). FT DOMAIN 294 318 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 318 AA; 35254 MW; D289E18D8A56FC57 CRC64; MQRANHSTVT QFILVGFSVF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHTPMY LFLCALSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFACH VPPLLKLACG DDVLVVAKGV GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS TCASHLTVVV VHYGFASVIY LKPKSPQSLE GDTLMGITYT VLTPFLSPII FSLRNKELKV AMKKTFFSKL YPEKNVMM // ID O5M9_HUMAN STANDARD; PRT; 310 AA. AC Q8NGP3; Q96RB9; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 5M9. GN OR5M9. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 66-281 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5M9". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065747; BAC05967.1; -. DR EMBL; AF399519; AAK95004.1; -. DR Genew; HGNC:15294; OR5M9. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 44 1 (Potential). FT DOMAIN 45 52 Cytoplasmic (Potential). FT TRANSMEM 53 73 2 (Potential). FT DOMAIN 74 97 Extracellular (Potential). FT TRANSMEM 98 118 3 (Potential). FT DOMAIN 119 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 4 (Potential). FT DOMAIN 159 194 Extracellular (Potential). FT TRANSMEM 195 215 5 (Potential). FT DOMAIN 216 235 Cytoplasmic (Potential). FT TRANSMEM 236 256 6 (Potential). FT DOMAIN 257 269 Extracellular (Potential). FT TRANSMEM 270 290 7 (Potential). FT DOMAIN 291 310 Cytoplasmic (Potential). FT DISULFID 95 187 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 310 AA; 35092 MW; 6D938CD1D4B7E7D1 CRC64; MPNFTDVTEF TLLGLTCRQE LQVLFFVVFL AVYMITLLGN IGMIILISIS PQLQSPMYFF LSHLSFADVC FSSNVTPKML ENLLSETKTI SYVGCLVQCY FFIAVVHVEV YILAVMAFDR YMAGCNPLLY GSKMSRTVCV RLISVPYVYG FSVSLICTLW TYGLYFCGNF EINHFYCADP PLIQIACGRV HIKEITMIVI AGINFTYSLS VVLISYTLIV VAVLRMRSAD GRRKAFSTCG SHLTAVSMFY GTPIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKEAVN KAITKTYVRQ // ID O2T2_HUMAN STANDARD; PRT; 323 AA. AC Q8NGX2; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 2T2. GN OR2T2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2T2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065644; BAC05870.1; -. DR Genew; HGNC:14725; OR2T2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 26 Extracellular (Potential). FT TRANSMEM 27 50 1 (Potential). FT DOMAIN 51 58 Cytoplasmic (Potential). FT TRANSMEM 59 80 2 (Potential). FT DOMAIN 81 101 Extracellular (Potential). FT TRANSMEM 102 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 292 7 (Potential). FT DOMAIN 293 323 Cytoplasmic (Potential). FT DISULFID 98 189 By similarity. FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 323 AA; 36101 MW; 4F6ADED325AF9E79 CRC64; MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA VVFSIFVVAI TANLVMILLI HMDSRLHTPM YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV QIFYLTLIGG EFFLLGLMAY DRYVAVCNPL RYPLLMNRRV CLFMVVGSWV GGSLDGFMLT PVTMSFPFCR SREINHFFCE IPAVLKLSCT DTSLYETLMY ACCVLMLLIP LSVISVSYTH ILLTVHRMNS AEGRRKAFAT CSSHIMVVSV FYGAAFYTNV LPHSYHTPEK DKVVSAFYTI LTPMLNPLIY SLRNKDVAAA LRKVLGRCGS SQSIRVATVI RKG // ID OAH5_HUMAN STANDARD; PRT; 315 AA. AC Q8NGA6; Q96R60; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 10H5. GN OR10H5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 68-284 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10H5". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065920; BAC06135.1; -. DR EMBL; AF399583; AAK95068.1; -. DR Genew; HGNC:15389; OR10H5. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 99 Extracellular (Potential). FT TRANSMEM 100 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 293 7 (Potential). FT DOMAIN 294 315 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 315 AA; 34900 MW; D43DAFA36E2F8F50 CRC64; MQGLNHTSVS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHMPMY LFLCALSITE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSLRG CTCRVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFFCH VPPLLKLACG DDVLVVAKGV GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS TCASHLTVVV VHYGFASVIY LKPKGPQSPE GDTLMGITYT VLTPFLSPII FSLRNKELKV AMKKTCFTKL FPQNC // ID O2M6_HUMAN STANDARD; PRT; 312 AA. AC Q8NG83; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 2M6. GN OR2M6. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2M6". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065952; BAC06165.1; -. DR Genew; HGNC:19593; OR2M6. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 236 Cytoplasmic (Potential). FT TRANSMEM 237 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 292 7 (Potential). FT DOMAIN 293 311 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 312 AA; 34827 MW; 5CEF428A1948C2F2 CRC64; MARENSTFNS DFILLGIFNH SPTHTFLFFL VLAIFSVAFM GNSVMVLLIY LDTQLHTPMY LLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCATQ IFFYTSLLGS ECFLLAVMAY DRYTAICHPL RYTNLMSPKI CGLMTAFSWI LGSTDGIIDV VATFSFSYCG SREIAHFFCD FPSLLILSCS DTSIFEKILF ICCIVMIVFP VAIIIASYAR VILAVIHMGS GEGRRKAFTT CSSHLLVVGM YYGAALFMYI RPTSDRSPTQ DKMVSVFYTI LTPMLNPLIY SLRNKEVTRA FMKILGKGKS GE // ID O2T4_HUMAN STANDARD; PRT; 320 AA. AC Q8NH00; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 2T4. GN OR2T4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2T4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065615; BAC05842.1; -. DR Genew; HGNC:15016; OR2T4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 29 Extracellular (Potential). FT TRANSMEM 30 53 1 (Potential). FT DOMAIN 54 61 Cytoplasmic (Potential). FT TRANSMEM 62 83 2 (Potential). FT DOMAIN 84 104 Extracellular (Potential). FT TRANSMEM 105 124 3 (Potential). FT DOMAIN 125 143 Cytoplasmic (Potential). FT TRANSMEM 144 162 4 (Potential). FT DOMAIN 163 199 Extracellular (Potential). FT TRANSMEM 200 223 5 (Potential). FT DOMAIN 224 240 Cytoplasmic (Potential). FT TRANSMEM 241 263 6 (Potential). FT DOMAIN 264 276 Extracellular (Potential). FT TRANSMEM 277 296 7 (Potential). FT DOMAIN 297 320 Cytoplasmic (Potential). FT DISULFID 101 193 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 190 190 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 320 AA; 36124 MW; 501ECD4B2377CF7D CRC64; MANITWMANH TGWSDFILLG LFRQSKHPAL LCVVIFVVFL MALSGNAVLI LLIHCDAHLH TPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKISAPE CGMQMFFYVT LAGSEFFLLA TMAYDRYVAI CHPLRYPVLM NHRVCLFLSS GCWFLGSVDG FTFTPITMTF PFRGSREIHH FFCEVPAVLN LSCSDTSLYE IFMYLCCVLM LLIPVVIISS SYLLILLTIH GMNSAEGRKK AFATCSSHLT VVILFYGAAI YTYMLPSSYH TPEKDMMVSV FYTILTPVVN PLIYSLRNKD VMGALKKMLT VEPAFQKAME // ID ODG1_HUMAN STANDARD; PRT; 307 AA. AC Q8NGZ3; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 13G1. GN OR13G1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR13G1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065623; BAC05849.1; -. DR Genew; HGNC:14999; OR13G1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 22 Extracellular (Potential). FT TRANSMEM 23 43 1 (Potential). FT DOMAIN 44 51 Cytoplasmic (Potential). FT TRANSMEM 52 72 2 (Potential). FT DOMAIN 73 96 Extracellular (Potential). FT TRANSMEM 97 117 3 (Potential). FT DOMAIN 118 136 Cytoplasmic (Potential). FT TRANSMEM 137 157 4 (Potential). FT DOMAIN 158 194 Extracellular (Potential). FT TRANSMEM 195 214 5 (Potential). FT DOMAIN 215 234 Cytoplasmic (Potential). FT TRANSMEM 235 255 6 (Potential). FT DOMAIN 256 268 Extracellular (Potential). FT TRANSMEM 269 289 7 (Potential). FT DOMAIN 290 307 Cytoplasmic (Potential). FT DISULFID 94 186 By similarity. FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 307 AA; 34672 MW; 5862C4DBB79414D6 CRC64; MNHSVVTEFI ILGLTKKPEL QGIIFLFFLI VYLVAFLGNM LIIIAKIYNN TLHTPMYVFL LTLAVVDIIC TTSIIPKMLG TMLTSENTIS YAGCMSQLFL FTWSLGAEMV LFTTMAYDRY VAICFPLHYS TIMNHHMCVA LLSMVMAIAV TNSWVHTALI MRLTFCGPNT IDHFFCEIPP LLALSCSPVR INEVMVYVAD ITLAIGDFIL TCISYGFIIV AILRIRTVEG KRKAFSTCSS HLTVVTLYYS PVIYTYIRPA SSYTFERDKV VAALYTLVTP TLNPMVYSFQ NREMQAGIRK VFAFLKH // ID ODA1_HUMAN STANDARD; PRT; 308 AA. AC Q8NGR1; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 13A1. GN OR13A1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR13A1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065728; BAC05949.1; -. DR Genew; HGNC:14772; OR13A1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 44 1 (Potential). FT DOMAIN 45 52 Cytoplasmic (Potential). FT TRANSMEM 53 73 2 (Potential). FT DOMAIN 74 97 Extracellular (Potential). FT TRANSMEM 98 118 3 (Potential). FT DOMAIN 119 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 215 5 (Potential). FT DOMAIN 216 235 Cytoplasmic (Potential). FT TRANSMEM 236 256 6 (Potential). FT DOMAIN 257 269 Extracellular (Potential). FT TRANSMEM 270 290 7 (Potential). FT DOMAIN 291 308 Cytoplasmic (Potential). FT DISULFID 95 187 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 308 AA; 34073 MW; 3001171DB5A8422F CRC64; MSNQTLVTEF ILQGFSEHPE YRVFLFSCFL FLYSGALTGN VLITLAITFN PGLHAPMYFF LLNLATMDII CTSSIMPKAL ASLVSEESSI SYGGCMAQLY FLTWAASSEL LLLTVMAYDR YAAICHPLHY SSMMSKVFCS GLATAVWLLC AVNTAIHTGL MLRLDFCGPN VIIHFFCEVP PLLLLSCSST YVNGVMIVLA DAFYGIVNFL MTIASYGFIV SSILKVKTAW GRQKAFSTCS SHLTVVCMYY TAVFYAYISP VSGYSAGKSK LAGLLYTVLS PTLNPLIYTL RNKEVKAALR KLFPFFRN // ID O4F6_HUMAN STANDARD; PRT; 312 AA. AC Q8NGB9; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 4F6. GN OR4F6 OR OR4F12. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4F6". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065899; BAC06115.1; -. DR Genew; HGNC:15372; OR4F6. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 79 2 (Potential). FT DOMAIN 80 100 Extracellular (Potential). FT TRANSMEM 101 120 3 (Potential). FT DOMAIN 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 158 4 (Potential). FT DOMAIN 159 195 Extracellular (Potential). FT TRANSMEM 196 219 5 (Potential). FT DOMAIN 220 235 Cytoplasmic (Potential). FT TRANSMEM 236 258 6 (Potential). FT DOMAIN 259 269 Extracellular (Potential). FT TRANSMEM 270 289 7 (Potential). FT DOMAIN 290 312 Cytoplasmic (Potential). FT DISULFID 97 189 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 312 AA; 35354 MW; B4FE59A4354F681A CRC64; MDEANHSVVS EFVFLGLSDS RKIQLLLFLF FSVFYVSSLM GNLLIVLTVT SDPRLQSPMY FLLANLSIIN LVFCSSTAPK MIYDLFRKHK TISFGGCVVQ IFFIHAVGGT EMVLLIAMAF DRYVAICKPL HYLTIMNPQR CILFLVISWI IGIIHSVIQL AFVVDLLFCG PNELDSFFCD LPRFIKLACI ETYTLGFMVT ANSGFISLAS FLILIISYIF ILVTVQKKSS GGIFKAFSML SAHVIVVVLV FGPLIFFYIF PFPTSHLDKF LAIFDAVITP VLNPVIYTFR NKEMMVAMRR RCSQFVNYSK IF // ID O4AG_HUMAN STANDARD; PRT; 328 AA. AC Q8NH70; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 4A16. GN OR4A16. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4A16". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065519; BAC05767.1; -. DR Genew; HGNC:15153; OR4A16. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 47 1 (Potential). FT DOMAIN 48 55 Cytoplasmic (Potential). FT TRANSMEM 56 77 2 (Potential). FT DOMAIN 78 98 Extracellular (Potential). FT TRANSMEM 99 118 3 (Potential). FT DOMAIN 119 137 Cytoplasmic (Potential). FT TRANSMEM 138 156 4 (Potential). FT DOMAIN 157 193 Extracellular (Potential). FT TRANSMEM 194 217 5 (Potential). FT DOMAIN 218 233 Cytoplasmic (Potential). FT TRANSMEM 234 256 6 (Potential). FT DOMAIN 257 267 Extracellular (Potential). FT TRANSMEM 268 287 7 (Potential). FT DOMAIN 288 328 Cytoplasmic (Potential). FT DISULFID 95 187 By similarity. FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 328 AA; 36921 MW; 033C46B6ABA70E62 CRC64; MRPSSNVTEF VLLGLTQDPD VKKTLFVMFL LIYIVTMVGN LLIWVTTIGS PSLGSLMYFF LAYLSLMDAI YSTAMSPKLM IDLLCDKIAI SLSACMGQLF IEHLLGGAEV FLLVVMAYDR YVAISKPLHY LNIMNRLVCI LLLVVAMIGG FVHSVVQIVF LYSLPICGPN VIDHSVCDMY PLLELLCLDT YFIGLTVVAN GGIICMVIFT FLLISCGVIL NFLKTYSQEE RHKALPTCIS HIIVVALVFV PCIFMYVRPV SNFPFDKLMT VFYSIITLML NPLIYSLRQS EMKNAMKNLW CEKLSIVRKR VSPTLNIFIP SSKATNRR // ID O3A4_HUMAN STANDARD; PRT; 348 AA. AC P47883; Q96R24; DT 01-FEB-1996 (Rel. 33, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 3A4 (Olfactory receptor 17-24) (OR17-24). GN OR3A4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE OF 71-286 FROM N.A. RX MEDLINE=94272458; PubMed=8004088; RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., RA Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., RA North M.A.; RT "Olfactory receptor gene cluster on human chromosome 17: possible RT duplication of an ancestral receptor repertoire."; RL Hum. Mol. Genet. 3:229-235(1994). RN [2] RP SEQUENCE OF 71-286 FROM N.A. RX MEDLINE=22202146; PubMed=12213199; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR3A4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U04680; AAA18344.1; -. DR EMBL; AF399621; AAK95106.1; -. DR PIR; I38472; I38472. DR Genew; HGNC:15510; OR3A4. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004984; F:olfactory receptor activity; NAS. DR GO; GO:0007608; P:perception of smell; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 Extracellular (Potential). FT TRANSMEM 29 52 1 (Potential). FT DOMAIN 53 60 Cytoplasmic (Potential). FT TRANSMEM 61 82 2 (Potential). FT DOMAIN 83 103 Extracellular (Potential). FT TRANSMEM 104 123 3 (Potential). FT DOMAIN 124 143 Cytoplasmic (Potential). FT TRANSMEM 144 161 4 (Potential). FT DOMAIN 162 199 Extracellular (Potential). FT TRANSMEM 200 222 5 (Potential). FT DOMAIN 223 239 Cytoplasmic (Potential). FT TRANSMEM 240 262 6 (Potential). FT DOMAIN 263 275 Extracellular (Potential). FT TRANSMEM 276 295 7 (Potential). FT DOMAIN 296 348 Cytoplasmic (Potential). FT DISULFID 100 192 By similarity. FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 348 AA; 37150 MW; 3136895C72E7E928 CRC64; MDLGNSGNDS VVTKFVLLGL TETAALQPIL FVIFLLAYVT TIGGTLSILA AILMETKLHS PMYFFLGNLS LPDVGCVSVT VPAMLSHFIS NDRSIPYKAC LSELFFFHLL AGADCFLLTI MAYDRYLAIC QSLTYSSRMS WGIQQALVGM SCVFSFTNAL TQTVALSPLN FCGPNVINHF YCDLPQPFQL SCASVHLNGQ LLFVAAAFMG VAPLVLITVS YAHVAAAVLR IRSAEGKKKA FSTCSSHLTV VGIFYGTGVF SYTRLGSVES SDKDKGIGIL NTVISPMLNP LIYWTSLLDV GCISHCSSDA GVSPGPPVQS SLCCLQFTAL LSPPPGWGGL SPLNSHGL // ID O6K2_HUMAN STANDARD; PRT; 324 AA. AC Q8NGY2; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 6K2. GN OR6K2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR6K2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065634; BAC05860.1; -. DR Genew; HGNC:15029; OR6K2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001092; HLH_basic. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 54 Cytoplasmic (Potential). FT TRANSMEM 55 75 2 (Potential). FT DOMAIN 76 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT DOMAIN 120 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT DOMAIN 160 198 Extracellular (Potential). FT TRANSMEM 199 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 293 7 (Potential). FT DOMAIN 294 324 Cytoplasmic (Potential). FT DISULFID 96 188 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 324 AA; 36513 MW; 7A59114C5A871A86 CRC64; MESPNRTTIQ EFIFSAFPYS WVKSVVCFVP LLFIYAFIVV GNLVIITVVQ LNTHLHTPMY TFISALSFLE IWYTTATIPK MLSSLLSERS ISFNGCLLQM YFFHSTGICE VCLLTVMAFD HYLAICSPLH YPSIMTPKLC TQLTLSCCVC GFITPLPEIA WISTLPFCGS NHLEHIFCDF LPVLRLACTD TRAIVMIQVV DVIHAVEIIT AVMLIFMSYD GIVAVILRIH SAGGRRTAFS TCVSHFIVFS LFFGSVTLMY LRFSATYSLF WDIAIALAFA VLSPFFNPII YSLRNKEIKE AIKKHIGQAK IFFSVRPGTS SKIF // ID OAD1_HUMAN STANDARD; PRT; 317 AA. AC Q8NGE0; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 10AD1. GN OR10AD1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10AD1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065872; BAC06090.1; -. DR Genew; HGNC:14819; OR10AD1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 55 Cytoplasmic (Potential). FT TRANSMEM 56 76 2 (Potential). FT DOMAIN 77 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT DOMAIN 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 161 4 (Potential). FT DOMAIN 162 198 Extracellular (Potential). FT TRANSMEM 199 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 272 Extracellular (Potential). FT TRANSMEM 273 293 7 (Potential). FT DOMAIN 294 317 Cytoplasmic (Potential). FT DISULFID 98 190 By similarity. FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 35698 MW; 72D856594467060F CRC64; MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS WTDPKLNSPM YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT QMYFVFCVGV AECILLAFMA YDRYVAICYP LNYVPIISQK VCVRLVGTAW FFGLINGIFL EYISFREPFR RDNHIESFFC EAPIVIGLSC GDPQFSLWAI FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS TCASHLTVVI FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE AMVRALGRTR LAQPQSV // ID OYP1_HUMAN STANDARD; PRT; 321 AA. AC Q8NH57; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52P1. GN OR52P1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52P1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065534; BAC05780.1; ALT_INIT. DR Genew; HGNC:15232; OR52P1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 6 (Potential). FT DOMAIN 261 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT DOMAIN 297 315 Cytoplasmic (Potential). FT DISULFID 99 191 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 321 AA; 34889 MW; 47329FE6ADC8CF22 CRC64; MESPNHTDVD PSVFFLLGIP GLEQFHLWLS LPVCGLGTAT IVGNITILVV VATEPVLHKP VYLFLCMLST IDLAASVSTV PKLLAIFWCG AGHISASACL AQMFFIHAFC MMESTVLLAM AFDRYVAICH PLRYATILTD TIIAHIGVAA VVRGSLLMLP CPFLIGRLNF CQSHVILHTY CEHMAVVKLA CGDTRPNRVY GLTAALLVIG VDLFCIGLSY ALSAQAVLRL SSHEARSKAL GTCGSHVCVI LISYTPALFS FFTHRFGHHV PVHIHILLAN VYLLLPPALN PVVYGVKTKQ IRKRVVRVFQ SGQGMGIKAS E // ID OYL1_HUMAN STANDARD; PRT; 314 AA. AC Q8NGH7; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52L1. GN OR52L1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52L1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065819; BAC06038.1; ALT_INIT. DR Genew; HGNC:14785; OR52L1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 Extracellular (Potential). FT TRANSMEM 29 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 78 2 (Potential). FT DOMAIN 79 102 Extracellular (Potential). FT TRANSMEM 103 123 3 (Potential). FT DOMAIN 124 142 Cytoplasmic (Potential). FT TRANSMEM 143 163 4 (Potential). FT DOMAIN 164 199 Extracellular (Potential). FT TRANSMEM 200 220 5 (Potential). FT DOMAIN 221 240 Cytoplasmic (Potential). FT TRANSMEM 241 261 6 (Potential). FT DOMAIN 262 276 Extracellular (Potential). FT TRANSMEM 277 297 7 (Potential). FT DOMAIN 298 314 Cytoplasmic (Potential). FT DISULFID 100 192 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 314 AA; 34557 MW; 6C022206DE6C1520 CRC64; MLLSNSSWRL SQPSFLLVGI PGLEESQHWI ALPLGILYLL ALVGNVTILF IIWMDPSLHQ SMYLFLSMLA AIDLVLASST APKALAVLLV HAHEIGYIVC LIQMFFIHAF SSMESGVLVA MALDRYVAIC HPLHHSTILH PGVIGRIGMV VLVRGLLLLI PFPILLGTLI FCQATIIGHA YCEHMAVVKL ACSETTVNRA YGLTMALLVI GLDVLAIGVS YAHILQAVLK VPGSEARLKA FSTCGSHICV ILVFYVPGIF SFLTHRFGHH VPHHVHVLLA TRYLLMPPAL NPLVYGVKTQ QIRQRVLRVF TQKD // ID OYK2_HUMAN STANDARD; PRT; 314 AA. AC Q8NGK3; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52K2. GN OR52K2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52K2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065791; BAC06010.1; -. DR Genew; HGNC:15223; OR52K2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Receptor; Transmembrane. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 6 (Potential). FT DOMAIN 261 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT DOMAIN 297 314 Cytoplasmic (Potential). FT DISULFID 99 191 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 314 AA; 34907 MW; 56D56A898904BC58 CRC64; MSASNITLTH PTAFLLVGIP GLEHLHIWIS IPFCLAYTLA LLGNCTLLLI IQADAALHEP MYLFLAMLAA IDLVLSSSAL PKMLAIFWFR DREINFFACL AQMFFLHSFS IMESAVLLAM AFDRYVAICK PLHYTKVLTG SLITKIGMAA VARAVTLMTP LPFLLRCFHY CRGPVIAHCY CEHMAVVRLA CGDTSFNNIY GIAVAMFIVV LDLLLVILSY IFILQAVLLL ASQEAHYKAF GTCVSHIGAI LAFYTTVVIS SVMHRVARHA APHVHILLAN FYLLFPPMVN PIIYGVKTKQ IRESILGVFP RKDM // ID OXE1_HUMAN STANDARD; PRT; 317 AA. AC Q8TCB6; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 51E1. GN OR51E1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR51E1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065787; BAC06006.1; -. DR EMBL; BC022401; AAH22401.1; -. DR Genew; HGNC:15194; OR51E1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 274 Extracellular (Potential). FT TRANSMEM 275 295 7 (Potential). FT DOMAIN 296 317 Cytoplasmic (Potential). FT DISULFID 99 191 By similarity. FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 90 90 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 35271 MW; 8C7293AA7FBCA95C CRC64; MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI VRTEHSLHEP MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL LQMFAIHSLS GMESTVLLAM AFDRYVAICH PLRHATVLTL PRVTKIGVAA VVRGAALMAP LPVFIKQLPF CRSNILSHSY CLHQDVMKLA CDDIRVNVVY GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG TCVSHVCAVF IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI RQRILRLFHV ATHASEP // ID OYN2_HUMAN STANDARD; PRT; 321 AA. AC Q8NGI0; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52N2. GN OR52N2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52N2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065816; BAC06035.1; -. DR Genew; HGNC:15228; OR52N2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 6 (Potential). FT DOMAIN 261 276 Extracellular (Potential). FT TRANSMEM 277 297 7 (Potential). FT DOMAIN 298 321 Cytoplasmic (Potential). FT DISULFID 99 191 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 321 AA; 35940 MW; A08A2658BD26477C CRC64; MSGDNSSSLT PGFFILNGVP GLEATHIWIS LPFCFMYIIA VVGNCGLICL ISHEEALHRP MYYFLALLSF TDVTLCTTMV PNMLCIFWFN LKEIDFNACL AQMFFVHMLT GMESGVLMLM ALDRYVAICY PLRYATILTN PVIAKAGLAT FLRNVMLIIP FTLLTKRLPY CRGNFIPHTY CDHMSVAKVS CGNFKVNAIY GLMVALLIGV FDICCISVSY TMILQAVMSL SSADARHKAF STCTSHMCSI VITYVAAFFT FFTHRFVGHN IPNHIHIIVA NLYLLLPPTM NPIVYGVKTK QIQEGVIKFL LGDKVSFTYD K // ID OXM1_HUMAN STANDARD; PRT; 315 AA. AC Q9H341; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 51M1 (HOR5'beta7). GN OR51M1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20570519; PubMed=11121057; RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., RA Felsenfeld G., Groudine M., Hardison R.; RT "Comparative structural and functional analysis of the olfactory RT receptor genes flanking the human and mouse beta-globin gene RT clusters."; RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000). CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR51M1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF137396; AAG41681.1; ALT_INIT. DR Genew; HGNC:14847; OR51M1. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004984; F:olfactory receptor activity; NAS. DR GO; GO:0007608; P:perception of smell; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 26 Extracellular (Potential). FT TRANSMEM 27 47 1 (Potential). FT DOMAIN 48 55 Cytoplasmic (Potential). FT TRANSMEM 56 76 2 (Potential). FT DOMAIN 77 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT DOMAIN 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 161 4 (Potential). FT DOMAIN 162 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT DOMAIN 219 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT DOMAIN 260 274 Extracellular (Potential). FT TRANSMEM 275 295 7 (Potential). FT DOMAIN 296 315 Cytoplasmic (Potential). FT DISULFID 98 190 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 315 AA; 35462 MW; DC19D2F5456D2005 CRC64; MLLSNITQFS PIFYLTSFPG LEGIKHWIFI PFFFMYMVAI SGNCFILIII KTNPRLHTPM YYLLSLLALT DLGLCVSTLP TTMGIFWFNS QSIYFGACQI QMFCIHSFSF MESSVLLMMS FDRFVAICHP LRYSVIITGQ QVVRAGLIVI FRGPVATIPI VLLLKAFPYC GSVVLSHSFC LHQEVIQLAC TDTTFNNLYG LMVVVFTVML DLVLIALSYG LILHTVAGLA SQEEQRRAFQ TCTAHRCAVL VFFVPMMGLS LVHRFGKHAP PAIHLLMANV YLFVPPMLNP IIYSIKTKEI HRAIIKLLGL KKASK // ID OYR1_HUMAN STANDARD; PRT; 315 AA. AC Q8NGF1; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52R1. GN OR52R1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52R1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065857; BAC06075.1; -. DR Genew; HGNC:15235; OR52R1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 28 Extracellular (Potential). FT TRANSMEM 29 49 1 (Potential). FT DOMAIN 50 57 Cytoplasmic (Potential). FT TRANSMEM 58 78 2 (Potential). FT DOMAIN 79 102 Extracellular (Potential). FT TRANSMEM 103 123 3 (Potential). FT DOMAIN 124 142 Cytoplasmic (Potential). FT TRANSMEM 143 163 4 (Potential). FT DOMAIN 164 199 Extracellular (Potential). FT TRANSMEM 200 220 5 (Potential). FT DOMAIN 221 240 Cytoplasmic (Potential). FT TRANSMEM 241 261 6 (Potential). FT DOMAIN 262 276 Extracellular (Potential). FT TRANSMEM 277 297 7 (Potential). FT DOMAIN 298 315 Cytoplasmic (Potential). FT DISULFID 100 192 By similarity. FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 315 AA; 34963 MW; EB0C4160E5786379 CRC64; MVLASGNSSS HPVSFILLGI PGLESFQLWI AFPFCATYAV AVVGNITLLH VIRIDHTLHE PMYLFLAMLA ITDLVLSSST QPKMLAIFWF HAHEIQYHAC LIQVFFIHAF SSVESGVLMA MALDCYVATC FPLRHSSILT PSVVIKLGTI VMLRGLLWVS PFCFMVSRMP FCQHQAIPQS YCEHMAVLKL VCADTSISRG YGLFVAFSVA GFDMIVIGMS YVMILRAVLQ LPSGEARLKA FSTRASHICV ILALYIPALF SFLTYRFGHD VPRVVHILFA NLYLLIPPML NPIIYGVRTK QIGDRVIQGC CGNIP // ID OYN1_HUMAN STANDARD; PRT; 320 AA. AC Q8NH53; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52N1. GN OR52N1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52N1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065538; BAC05784.1; -. DR Genew; HGNC:14853; OR52N1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 6 (Potential). FT DOMAIN 261 276 Extracellular (Potential). FT TRANSMEM 277 297 7 (Potential). FT DOMAIN 298 320 Cytoplasmic (Potential). FT DISULFID 99 191 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 320 AA; 35784 MW; 37718814BE6B6D2E CRC64; MSFLNGTSLT PASFILNGIP GLEDVHLWIS FPLCTMYSIA ITGNFGLMYL IYCDEALHRP MYVFLALLSF TDVLMCTSTL PNTLFILWFN LKEIDFKACL AQMFFVHTFT GMESGVLMLM ALDHCVAICF PLRYATILTN SVIAKAGFLT FLRGVMLVIP STFLTKRLPY CKGNVIPHTY CDHMSVAKIS CGNVRVNAIY GLIVALLIGG FDILCITISY TMILQAVVSL SSADARQKAF STCTAHFCAI VLTYVPAFFT FFTHHFGGHT IPLHIHIIMA NLYLLMPPTM NPIVYGVKTR QVRESVIRFF LKGKDNSHNF // ID OXT1_HUMAN STANDARD; PRT; 327 AA. AC Q8NGJ9; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 51T1. GN OR51T1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR51T1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065795; BAC06014.1; -. DR Genew; HGNC:15205; OR51T1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 6 (Potential). FT DOMAIN 261 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT DOMAIN 297 327 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 327 AA; 36998 MW; 357B024140657D44 CRC64; MAIFNNTTSS SSNFLLTAFP GLECAHVWIS IPVCCLYTIA LLGNSMIFLV IITKRRLHKP MYYFLSMLAA VDLCLTITTL PTVLGVLWFH AREISFKACF IQMFFVHAFS LLESSVLVAM AFDRFVAICN PLNYATILTD RMVLVIGLVI CIRPAVFLLP LLVAINTVSF HGGHELSHPF CYHPEVIKYT YSKPWISSFW GLFLQLYLNG TDVLFILFSY VLILRTVLGI VARKKQQKAL STCVCHICAV TIFYVPLISL SLAHRLFHST PRVLCSTLAN IYLLLPPVLN PIIYSLKTKT IRQAMFQLLQ SKGSWGFNVR GLRGRWD // ID OYB4_HUMAN STANDARD; PRT; 314 AA. AC Q8NGK2; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 52B4. GN OR52B4. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR52B4". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065792; BAC06011.1; -. DR Genew; HGNC:15209; OR52B4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 6 (Potential). FT DOMAIN 261 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT DOMAIN 297 314 Cytoplasmic (Potential). FT DISULFID 99 191 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 314 AA; 35622 MW; 001831FCAA557474 CRC64; MPTVNHSGTS HTVFHLLGIP GLQDQHMWIS IPFFISYVTA LLGNSLLIFI ILTKRSLHEP MYLFLCMLAG ADIVLSTCTI PQALAIFWFR AGDISLDRCI TQLFFIHSTF ISESGILLVM AFDHYIAICY PLRYTTILTN ALIKKICVTV SLRSYGTIFP IIFLLKRLTF CQNNIIPHTF CEHIGLAKYA CNDIRINIWY GFSILMSTVV LDVVLIFISY MLILHAVFHM PSPDACHKAL NTFGSHVCII ILFYGSGIFT ILTQRFGRHI PPCIHIPLXN VCILAPPMLN PIIYGIKTKQ IQEQVVQFLF IKQK // ID OXG2_HUMAN STANDARD; PRT; 314 AA. AC Q8NGK0; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 51G2. GN OR51G2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR51G2". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065794; BAC06013.1; -. DR Genew; HGNC:15198; OR51G2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 30 Extracellular (Potential). FT TRANSMEM 31 51 1 (Potential). FT DOMAIN 52 59 Cytoplasmic (Potential). FT TRANSMEM 60 80 2 (Potential). FT DOMAIN 81 104 Extracellular (Potential). FT TRANSMEM 105 125 3 (Potential). FT DOMAIN 126 144 Cytoplasmic (Potential). FT TRANSMEM 145 165 4 (Potential). FT DOMAIN 166 201 Extracellular (Potential). FT TRANSMEM 202 222 5 (Potential). FT DOMAIN 223 242 Cytoplasmic (Potential). FT TRANSMEM 243 263 6 (Potential). FT DOMAIN 264 278 Extracellular (Potential). FT TRANSMEM 279 299 7 (Potential). FT DOMAIN 300 314 Cytoplasmic (Potential). FT DISULFID 102 194 By similarity. FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 314 AA; 35012 MW; 97DD37E1F38E976C CRC64; MTLGSLGNSS SSVSATFLLS GIPGLERMHI WISIPLCFMY LVSIPGNCTI LFIIKTERSL HEPMYLFLSM LALIDLGLSL CTLPTVLGIF WVGAREISHD ACFAQLFFIH CFSFLESSVL LSMAFDRFVA ICHPLHYVSI LTNTVIGRIG LVSLGRSVAL IFPLPFMLKR FPYCGSPVLS HSYCLHQEVM KLACADMKAN SIYGMFVIVS TVGIDSLLIL FSYALILRTV LSIASRAERF KALNTCVSHI CAVLLFYTPM IGLSVIHRFG KQAPHLVQVV MGFMYLLFPP VMNPIVYSVK TKQIRDRVTH AFCY // ID OXH1_HUMAN STANDARD; PRT; 302 AA. AC Q8NH63; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Olfactory receptor 51H1. GN OR51H1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative odorant receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- DATABASE: NAME=Human Olfactory Receptor Data Exploratorium (HORDE); CC WWW="http://bioinformatics.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR51H1". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB065527; BAC05774.1; -. DR Genew; HGNC:14833; OR51H1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR TIGRFAMs; TIGR01870; cas_TM1810; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Olfaction. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 56 Cytoplasmic (Potential). FT TRANSMEM 57 77 2 (Potential). FT DOMAIN 78 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT DOMAIN 163 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT DOMAIN 220 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 6 (Potential). FT DOMAIN 261 276 Extracellular (Potential). FT TRANSMEM 277 297 7 (Potential). FT DOMAIN 298 302 Cytoplasmic (Potential). FT DISULFID 99 191 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 302 AA; 33766 MW; A07C915DF5CA6734 CRC64; MTNLNASQAN HRNFILTGIP GTPDKNPWLA FPLGFLYTLT LLGNGTILAV IKVEPSLHEP TYYFLSILAL TDVSLSMSTL PSMLSIYWFN APQIVFDACI MQMFFIHVFG IVESGVLVSM AFDRFVAIRN PLHYVSILTH DVIRKTGIAV LTRAVCVVFP VPFLIKCLPF CHSNVLSHSY CLHQNMMRLA CASTRINSLY GLIVVIFTLG LDVLLTLLSY VLTLKTVLGI VSRGERLKTL STCLSHMSTV LLFYVPFMGA ASMIHRFWEH LSPVVHMVMA DIYLLLPPVL NPIVYSVKTK QI // ID PE24_RAT STANDARD; PRT; 488 AA. AC P43114; O08728; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Prostaglandin E2 receptor, EP4 subtype (Prostanoid EP4 receptor) (PGE DE receptor, EP4 subtype). GN PTGER4. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=94241990; PubMed=8185583; RA Sando T., Usui T., Tanaka I., Mori K., Sasaki Y., Fukuda Y., RA Namba T., Sugimoto Y., Ichikawa A., Narumiya S., Nakao K.; RT "Molecular cloning and expression of rat prostaglandin E receptor EP2 RT subtype."; RL Biochem. Biophys. Res. Commun. 200:1329-1333(1994). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Kidney; RX MEDLINE=98141044; PubMed=9537820; RA Boie Y., Stocco R., Sawyer N., Slipetz D.M., Ungrin M.D., RA Neuschafer-Rube F., Puschel G.P., Metters K.M., Abramovitz M.; RT "Molecular cloning and characterization of the four rat prostaglandin RT E2 prostanoid receptor subtypes."; RL Eur. J. Pharmacol. 340:227-241(1997). CC -!- FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of CC this receptor is mediated by G(s) proteins that stimulate CC adenylate cyclase. Has a relaxing effect on smooth muscle. May CC play an important role in regulating renal hemodynamics, CC intestinal epithelial transport, adrenal aldosterone secretion, CC and uterine function. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- CAUTION: Was originally designated as the EP2 subtype. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D28860; BAA06011.1; -. DR EMBL; U94709; AAB53326.1; -. DR PIR; JC2241; JC2241. DR RGD; 628641; Ptger4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008365; ProstanoidR. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00428; PROSTAGLNDNR. DR PRINTS; PR01788; PROSTANOIDR. DR PRINTS; PR00586; PRSTNOIDEP4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 19 Extracellular (Potential). FT TRANSMEM 20 43 1 (Potential). FT DOMAIN 44 55 Cytoplasmic (Potential). FT TRANSMEM 56 79 2 (Potential). FT DOMAIN 80 96 Extracellular (Potential). FT TRANSMEM 97 115 3 (Potential). FT DOMAIN 116 135 Cytoplasmic (Potential). FT TRANSMEM 136 160 4 (Potential). FT DOMAIN 161 184 Extracellular (Potential). FT TRANSMEM 185 211 5 (Potential). FT DOMAIN 212 270 Cytoplasmic (Potential). FT TRANSMEM 271 298 6 (Potential). FT DOMAIN 299 315 Extracellular (Potential). FT TRANSMEM 316 335 7 (Potential). FT DOMAIN 336 488 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT DISULFID 92 170 By similarity. FT DOMAIN 230 235 Poly-Ala. FT CONFLICT 214 214 L -> H (in Ref. 2). FT CONFLICT 396 396 H -> Q (in Ref. 2). SQ SEQUENCE 488 AA; 53365 MW; C2EE713018723FF4 CRC64; MSIPGVNASF SSTPERLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK ETTFYTLVCG LAVTDLLGTL LVSPVTIATY MKGQWPGDQA LCDYSTFILL FFGLSGLSII CAMSIERYLA INHAYFYSHY VDKRLAGLTL FAVYASNVLF CALPNMGLGR SERQYPGTWC FIDWTTNVTA YAAFSYMYAG FSSFLILATV LCNVLVCGAL LRMLRQFMRR TSLGTEQHHA AAAAAVASVA CRGHAAASPA LQRLSDFRRR RSFRRIAGAE IQMVILLIAT SLVVLICSIP LVVRVFINQL YQPSVVKDIS RNPDLQAIRI ASVNPILDPW IYILLRKTVL SKAIEKIKCL FCRIGGSGRD GSAQHCSESR RTSSAMSGHS RSFLSRELRE ISSTSHTLLY LPDLTESSLG GKNLLPGTHG MGLTQADTTS LRTLRISETS DSSQGQDSES VLLVDEVSGS QREEPASKGN SLQVTFPSET LKLSEKCI // ID PE24_HUMAN STANDARD; PRT; 488 AA. AC P35408; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Prostaglandin E2 receptor, EP4 subtype (Prostanoid EP4 receptor) (PGE DE receptor, EP4 subtype). GN PTGER4 OR PTGER2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=94216291; PubMed=8163486; RA Bastien L., Sawyer N., Grygorczyk R., Metters K.M., Adam M.; RT "Cloning, functional expression, and characterization of the human RT prostaglandin E2 receptor EP2 subtype."; RL J. Biol. Chem. 269:11873-11877(1994). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=94071953; PubMed=8250933; RA An S., Yang J., Xia M., Goetzl E.J.; RT "Cloning and expression of the EP2 subtype of human receptors for RT prostaglandin E2."; RL Biochem. Biophys. Res. Commun. 197:263-270(1993). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=96299755; PubMed=8661119; RA Foord S.M., Marks B., Stolz M., Bufflier E., Fraser N.J., Lee M.G.; RT "The structure of the prostaglandin EP4 receptor gene and related RT pseudogenes."; RL Genomics 35:182-188(1996). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=97015877; PubMed=8862514; RA Mori K., Tanaka I., Kotani M., Miyaoka F., Sando T., Muro S., RA Sasaki Y., Nakagawa O., Ogawa Y., Usui T., Ozaki S., Ichikawa A., RA Narumiya S., Nakao K.; RT "Gene expression of the human prostaglandin E receptor EP4 subtype: RT differential regulation in monocytoid and lymphoid lineage cells by RT phorbol ester."; RL J. Mol. Med. 74:333-336(1996). CC -!- FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of CC this receptor is mediated by G(s) proteins that stimulate CC adenylate cyclase. Has a relaxing effect on smooth muscle. May CC play an important role in regulating renal hemodynamics, CC intestinal epithelial transport, adrenal aldosterone secretion, CC and uterine function. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: High in intestine and in peripheral blood CC mononuclear cells; low in lung, kidney, thymus, uterus, CC vasculature and brain. Not found in liver, heart, retina oe CC skeletal muscle. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- CAUTION: Was originally designated as the EP2 subtype. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L28175; AAA36434.1; -. DR EMBL; L25124; AAA36438.1; -. DR EMBL; X97873; CAA66463.1; -. DR EMBL; X97874; CAA66463.1; JOINED. DR EMBL; D28472; BAA05834.1; -. DR PIR; A53572; A53572. DR Genew; HGNC:9596; PTGER4. DR MIM; 601586; -. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0004957; F:prostaglandin E receptor activity; TAS. DR GO; GO:0007188; P:G-protein signaling, coupled to cAMP nucleo...; TAS. DR GO; GO:0006955; P:immune response; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008365; ProstanoidR. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00428; PROSTAGLNDNR. DR PRINTS; PR01788; PROSTANOIDR. DR PRINTS; PR00586; PRSTNOIDEP4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 19 Extracellular (Potential). FT TRANSMEM 20 43 1 (Potential). FT DOMAIN 44 55 Cytoplasmic (Potential). FT TRANSMEM 56 79 2 (Potential). FT DOMAIN 80 96 Extracellular (Potential). FT TRANSMEM 97 115 3 (Potential). FT DOMAIN 116 135 Cytoplasmic (Potential). FT TRANSMEM 136 160 4 (Potential). FT DOMAIN 161 184 Extracellular (Potential). FT TRANSMEM 185 211 5 (Potential). FT DOMAIN 212 267 Cytoplasmic (Potential). FT TRANSMEM 268 295 6 (Potential). FT DOMAIN 296 312 Extracellular (Potential). FT TRANSMEM 313 332 7 (Potential). FT DOMAIN 333 488 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT DISULFID 92 170 By similarity. FT DOMAIN 230 234 Poly-Ala. FT CONFLICT 464 466 GPA -> WAC (in Ref. 2). SQ SEQUENCE 488 AA; 53119 MW; D028478CD72C85EE CRC64; MSTPGVNSSA SLSPDRLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK ETTFYTLVCG LAVTDLLGTL LVSPVTIATY MKGQWPGGQP LCEYSTFILL FFSLSGLSII CAMSVERYLA INHAYFYSHY VDKRLAGLTL FAVYASNVLF CALPNMGLGS SRLQYPDTWC FIDWTTNVTA HAAYSYMYAG FSSFLILATV LCNVLVCGAL LRMHRQFMRR TSLGTEQHHA AAAASVASRG HPAASPALPR LSDFRRRRSF RRIAGAEIQM VILLIATSLV VLICSIPLVV RVFVNQLYQP SLEREVSKNP DLQAIRIASV NPILDPWIYI LLRKTVLSKA IEKIKCLFCR IGGSRRERSG QHCSDSQRTS SAMSGHSRSF ISRELKEISS TSQTLLPDLS LPDLSENGLG GRNLLPGVPG MGLAQEDTTS LRTLRISETS DSSQGQDSES VLLVDEAGGS GRAGPAPKGS SLQVTFPSET LNLSEKCI // ID PI2R_HUMAN STANDARD; PRT; 386 AA. AC P43119; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) DE (Prostaglandin I2 receptor). GN PTGIR OR PRIPR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=94216334; PubMed=7512962; RA Boie Y., Rushmore T.H., Darmon-Goodwin A., Grygorczyk R., RA Slipetz D.M., Metters K.M., Abramovitz M.; RT "Cloning and expression of a cDNA for the human prostanoid IP RT receptor."; RL J. Biol. Chem. 269:12173-12178(1994). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=94237286; PubMed=7514139; RA Katsuyama M., Sugimoto Y., Namba T., Irie A., Negishi M., RA Narumiya S., Ichikawa A.; RT "Cloning and expression of a cDNA for the human prostacyclin RT receptor."; RL FEBS Lett. 344:74-78(1994). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Lung; RX MEDLINE=95008086; PubMed=7923647; RA Nakagawa O., Tanaka I., Usui T., Harada M., Sasaki Y., Itoh H., RA Yoshimasa T., Namba T., Narumiya S., Nakao K.; RT "Molecular cloning of human prostacyclin receptor cDNA and its gene RT expression in the cardiovascular system."; RL Circulation 90:1643-1647(1994). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=95394450; PubMed=7665161; RA Ogawa Y., Tanaka I., Inoue M., Yoshitake Y., Isse N., Nakagawa O., RA Usui T., Itoh H., Yoshimasa T., Narumiya S.; RT "Structural organization and chromosomal assignment of the human RT prostacyclin receptor gene."; RL Genomics 27:142-148(1995). RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RA Warren C.N., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [6] RP PALMITOYLATION. RX MEDLINE=22486644; PubMed=12488443; RA Miggin S.M., Lawler O.A., Kinsella B.T.; RT "Palmitoylation of the human prostacyclin receptor. Functional RT implications of palmitoylation and isoprenylation."; RL J. Biol. Chem. 278:6947-6958(2003). CC -!- FUNCTION: Receptor for prostacyclin (prostaglandin I2 or PGI2). CC The activity of this receptor is mediated by G(s) proteins which CC activate adenylate cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L29016; AAA36448.1; -. DR EMBL; D25418; BAA05008.1; -. DR EMBL; D29634; BAA06110.1; -. DR EMBL; D38127; BAA07325.1; -. DR EMBL; D38128; BAA07325.1; JOINED. DR EMBL; AY242134; AAO92301.1; -. DR PIR; A57066; A57066. DR Genew; HGNC:9602; PTGIR. DR MIM; 600022; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004959; F:prostaglandin I receptor activity; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008365; ProstanoidR. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01788; PROSTANOIDR. DR PRINTS; PR00429; THROMBOXANER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate. FT DOMAIN 1 16 Extracellular (Potential). FT TRANSMEM 17 38 1 (Potential). FT DOMAIN 39 51 Cytoplasmic (Potential). FT TRANSMEM 52 76 2 (Potential). FT DOMAIN 77 94 Extracellular (Potential). FT TRANSMEM 95 115 3 (Potential). FT DOMAIN 116 134 Cytoplasmic (Potential). FT TRANSMEM 135 158 4 (Potential). FT DOMAIN 159 181 Extracellular (Potential). FT TRANSMEM 182 208 5 (Potential). FT DOMAIN 209 235 Cytoplasmic (Potential). FT TRANSMEM 236 260 6 (Potential). FT DOMAIN 261 274 Extracellular (Potential). FT TRANSMEM 275 295 7 (Potential). FT DOMAIN 296 386 Cytoplasmic (Potential). FT LIPID 308 308 S-palmitoyl cysteine. FT LIPID 311 311 S-palmitoyl cysteine. FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 386 AA; 40955 MW; 2B6B0CDBACED1608 CRC64; MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA VLVTGLAATD LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT FFGLASMLIL FAMAVERCLA LSHPYLYAQL DGPRCARLAL PAIYAFCVLF CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG GAAFSLAYAG LVALLVAAIF LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL LALMTVVMAV CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS AWGEGQVEPL PPTQQSSGSA VGTSSKAEAS VACSLC // ID TA2R_RAT STANDARD; PRT; 341 AA. AC P34978; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) (TXR2). GN TBXA2R. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Kidney; RX MEDLINE=95362824; PubMed=7635958; RA Abe T., Takeuchi K., Takahashi N., Tsutsumi E., Taniyama Y., Abe K.; RT "Rat kidney thromboxane receptor: molecular cloning, signal RT transduction, and intrarenal expression localization."; RL J. Clin. Invest. 96:657-664(1995). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RX MEDLINE=95210358; PubMed=7696353; RA Kitanaka J., Hashimoto H., Sugimoto Y., Sawada M., Negishi M., RA Suzumura A., Marunouchi T., Ichikawa A., Baba A.; RT "cDNA cloning of a thromboxane A2 receptor from rat astrocytes."; RL Biochim. Biophys. Acta 1265:220-223(1995). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Kidney; RX MEDLINE=97090677; PubMed=8936585; RA D'Angelo D.D., Terasawa T., Carlisle S.J., Dorn G.W. II, Lynch K.R.; RT "Characterization of a rat kidney thromboxane A2 receptor: high RT affinity for the agonist ligand I-BOP."; RL Prostaglandins 52:303-316(1996). CC -!- FUNCTION: RECEPTOR FOR THROMBOXANE A2 (TXA2), A POTENT STIMULATOR CC OF PLATELET AGGREGATION. THE ACTIVITY OF THIS RECEPTOR IS MEDIATED CC BY A G-PROTEIN THAT ACTIVATE A PHOSPHATIDYLINOSITOL-CALCIUM SECOND CC MESSENGER SYSTEM. IN THE KIDNEY, THE BINDING OF TXA2 TO GLOMERULAR CC TP RECEPTORS CAUSES INTENSE VASOCONSTRICTION. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: IN THE BRAIN, EXPRESSED IN ALL TYPES OF GLIAL CC CELLS. IN THE KIDNEY, EXPRESSED IN THE MESANGIAL CELLS OF THE CC GLOMERULUS, SMOOTH MUSCLE CELLS OF THE RENAL ARTERIOLES, AND IN CC TRANSITIONAL CELL EPITHELIUM OF RENAL PELVIS. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D21158; BAA04694.1; -. DR EMBL; D32080; BAA06844.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 29 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 30 52 1 (POTENTIAL). FT DOMAIN 53 65 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 66 86 2 (POTENTIAL). FT DOMAIN 87 105 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 106 127 3 (POTENTIAL). FT DOMAIN 128 147 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 148 170 4 (POTENTIAL). FT DOMAIN 171 191 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 192 217 5 (POTENTIAL). FT DOMAIN 218 244 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 245 268 6 (POTENTIAL). FT DOMAIN 269 287 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 288 309 7 (POTENTIAL). FT DOMAIN 310 341 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 16 16 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 104 181 BY SIMILARITY. FT CONFLICT 188 188 E -> G (IN REF. 2). SQ SEQUENCE 341 AA; 36927 MW; E85843FE54C1CD94 CRC64; MWLNSTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAVVASQHAA LLDWRATDPG CRLCHFMGAA MVFFGLCPLL LGAAMAAERF VGITRPFSRP AATSRRAWAT VGLVWVGAGT LGLLPLLGLG RYSVQYPGSW CFLTLGAERG DVAFGLMFAL LGSVSVGLSL LLNTVSVATL CRVYHAREAT QRPRDCEVEM MVQLVGIMVV ATVCWMPLLV FILQTLLQTL PVMSPSGQLL RTTERQLLIY LRVATWNQIL DPWVYILFRR SVLRRLHPRF TSQLQAVSLH SPPTQAMLSG P // ID P2YR_MELGA STANDARD; PRT; 362 AA. AC P49652; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE P2Y purinoceptor 1 (ATP receptor) (P2Y1) (Purinergic receptor) (6H1 DE orphan receptor). GN P2RY1. OS Meleagris gallopavo (Common turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Meleagris. OX NCBI_TaxID=9103; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=94335907; PubMed=8058061; RA Filtz T.M., Li Q., Boyer J.L., Nicholas R.A., Harden T.K.; RT "Expression of a cloned P2Y purinergic receptor that couples to RT phospholipase C."; RL Mol. Pharmacol. 46:8-14(1994). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=97382456; PubMed=9240460; RA Li Q., Schachter J.B., Harden T.K., Nicholas R.A.; RT "The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not RT mediate nucleotide-promoted second messenger responses."; RL Biochem. Biophys. Res. Commun. 236:455-460(1997). CC -!- FUNCTION: Receptor for extracellular adenine nucleotides such as CC ATP and ADP. Seems to mediate its action via a pertussis toxin CC insensitive G-protein, probably belonging to the Gq family that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Mainly found in blood, brain, and lung. To a CC lesser extent in stomach, gut and skeletal muscle. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U09842; AAA18784.1; -. DR EMBL; AF012103; AAB65428.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 41 Extracellular (Potential). FT TRANSMEM 42 63 1 (Potential). FT DOMAIN 64 76 Cytoplasmic (Potential). FT TRANSMEM 77 98 2 (Potential). FT DOMAIN 99 115 Extracellular (Potential). FT TRANSMEM 116 136 3 (Potential). FT DOMAIN 137 155 Cytoplasmic (Potential). FT TRANSMEM 156 177 4 (Potential). FT DOMAIN 178 207 Extracellular (Potential). FT TRANSMEM 208 227 5 (Potential). FT DOMAIN 228 254 Cytoplasmic (Potential). FT TRANSMEM 255 274 6 (Potential). FT DOMAIN 275 292 Extracellular (Potential). FT TRANSMEM 293 317 7 (Potential). FT DOMAIN 318 362 Cytoplasmic (Potential). FT DISULFID 113 191 By similarity. FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT CARBOHYD 102 102 N-linked (GlcNAc...) (Potential). FT CARBOHYD 186 186 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 362 AA; 41180 MW; 3E128AB9EB64349C CRC64; MTEALISAAL NGTQPELLAG GWAAGNASTK CSLTKTGFQF YYLPTVYILV FITGFLGNSV AIWMFVFHMR PWSGISVYMF NLALADFLYV LTLPALIFYY FNKTDWIFGD VMCKLQRFIF HVNLYGSILF LTCISVHRYT GVVHPLKSLG RLKKKNAVYV SSLVWALVVA VIAPILFYSG TGVRRNKTIT CYDTTADEYL RSYFVYSMCT TVFMFCIPFI VILGCYGLIV KALIYKDLDN SPLRRKSIYL VIIVLTVFAV SYLPFHVMKT LNLRARLDFQ TPQMCAFNDK VYATYQVTRG LASLNSCVDP ILYFLAGDTF RRRLSRATRK SSRRSEPNVQ SKSEEMTLNI LTEYKQNGDT SL // ID AA1R_CANFA STANDARD; PRT; 326 AA. AC P11616; DT 01-OCT-1989 (Rel. 12, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Adenosine A1 receptor. GN ADORA1 OR RDC7. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Thyroid; RX MEDLINE=89242119; PubMed=2541503; RA Libert F., Parmentier M., Lefort A., Dinsart C., van Sande J., RA Maenhaut C., Simons M.-J., Dumont J.E., Vassart G.; RT "Selective amplification and cloning of four new members of the G RT protein-coupled receptor family."; RL Science 244:569-572(1989). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Thyroid; RX MEDLINE=90245609; PubMed=2159629; RA Libert F., Parmentier M., Lefort A., Dumont J.E., Vassart G.; RT "Complete nucleotide sequence of a putative G protein coupled RT receptor: RDC7."; RL Nucleic Acids Res. 18:1915-1915(1990). RN [3] RP FUNCTION. RX MEDLINE=91266895; PubMed=1646713; RA Libert F., Schiffmann S.N., Lefort A., Parmentier M., Gerard C., RA Dumont J.E., Vanderhaeghen J.-J., Vassart G.; RT "The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor."; RL EMBO J. 10:1677-1682(1991). CC -!- FUNCTION: RECEPTOR FOR ADENOSINE. THE ACTIVITY OF THIS RECEPTOR CC IS MEDIATED BY G PROTEINS WHICH INHIBIT ADENYLYL CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X14051; CAA32209.1; -. DR PIR; C30341; C30341. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 10 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 11 33 1 (POTENTIAL). FT DOMAIN 34 46 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 47 69 2 (POTENTIAL). FT DOMAIN 70 80 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 81 102 3 (POTENTIAL). FT DOMAIN 103 123 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 124 146 4 (POTENTIAL). FT DOMAIN 147 176 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 177 201 5 (POTENTIAL). FT DOMAIN 202 235 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 236 259 6 (POTENTIAL). FT DOMAIN 260 267 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 268 292 7 (POTENTIAL). FT DOMAIN 293 326 CYTOPLASMIC (POTENTIAL). FT DISULFID 80 169 BY SIMILARITY. FT CARBOHYD 159 159 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 309 309 S-palmitoyl cysteine (Potential). SQ SEQUENCE 326 AA; 36399 MW; D55FCE6914AEA50E CRC64; MPPAISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA LVIPLAILIN IGPRTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKTVVT PRRAAVAIAG CWILSFVVGL TPLFGWNRLG EAQRAWAANG SGGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY LEVFYLIRRQ LGKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL HILNCITLFC PSCRKPSILM YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL KIWNDHFRCQ PTPPVDEDPP EEAPHD // ID AA2A_CANFA STANDARD; PRT; 412 AA. AC P11617; DT 01-OCT-1989 (Rel. 12, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Adenosine A2a receptor. GN ADORA2A OR RDC8. OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Thyroid; RX MEDLINE=89242119; PubMed=2541503; RA Libert F., Parmentier M., Lefort A., Dinsart C., van Sande J., RA Maenhaut C., Simons M.-J., Dumont J.E., Vassart G.; RT "Selective amplification and cloning of four new members of the G RT protein-coupled receptor family."; RL Science 244:569-572(1989). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Thyroid; RX MEDLINE=90245608; PubMed=2159628; RA Libert F., Parmentier M., Lefort A., Dumont J.E., Vassart G.; RT "Complete nucleotide sequence of a putative G protein coupled RT receptor: RDC8."; RL Nucleic Acids Res. 18:1914-1914(1990). RN [3] RP FUNCTION. RX MEDLINE=91097545; PubMed=2125216; RA Maenhaut C., van Sande J., Libert F., Abramowicz M., Parmentier M., RA Vanderhaegen J.-J., Dumont J.E., Vassart G., Schiffmann S.; RT "RDC8 codes for an adenosine A2 receptor with physiological RT constitutive activity."; RL Biochem. Biophys. Res. Commun. 173:1169-1178(1990). CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is CC mediated by G proteins which activate adenylyl cyclase. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X14052; CAA32210.1; -. DR PIR; D30341; D30341. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00553; ADENOSINA2AR. DR PRINTS; PR00424; ADENOSINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 7 Extracellular (Potential). FT TRANSMEM 8 30 1 (Potential). FT DOMAIN 31 43 Cytoplasmic (Potential). FT TRANSMEM 44 66 2 (Potential). FT DOMAIN 67 77 Extracellular (Potential). FT TRANSMEM 78 100 3 (Potential). FT DOMAIN 101 120 Cytoplasmic (Potential). FT TRANSMEM 121 143 4 (Potential). FT DOMAIN 144 173 Extracellular (Potential). FT TRANSMEM 174 198 5 (Potential). FT DOMAIN 199 234 Cytoplasmic (Potential). FT TRANSMEM 235 258 6 (Potential). FT DOMAIN 259 266 Extracellular (Potential). FT TRANSMEM 267 290 7 (Potential). FT DOMAIN 291 412 Cytoplasmic (Potential). FT DISULFID 77 166 By similarity. FT CARBOHYD 145 145 N-linked (GlcNAc...) (Potential). FT CARBOHYD 154 154 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 412 AA; 45060 MW; EB1B094AD581C6A7 CRC64; MSTMGSWVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI PFAITISTGF CAACHNCLFF ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR AKGIIAVCWV LSFAIGLTPM LGWNNCSQPK EGRNYSQGCG EGQVACLFED VVPMNYMVYY NFFAFVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH IINCFTFFCP ECSHAPLWLM YLTIVLSHTN SVVNPFIYAY RIREFRQTFR KIIRSHVLRR REPFKAGGTS ARALAAHGSD GEQISLRLNG HPPGVWANGS APHPERRPNG YTLGLVSGGI APESHGDMGL PDVELLSHEL KGACPESPGL EGPLAQDGAG VS // ID P2Y2_RAT STANDARD; PRT; 374 AA. AC P41232; DT 01-FEB-1995 (Rel. 31, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) DE (Purinergic receptor). GN P2RY2 OR P2RU1. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95110548; PubMed=7811468; RA Rice W.R., Burton F.M., Fiedeldey D.T.; RT "Cloning and expression of the alveolar type II cell P2u-purinergic RT receptor."; RL Am. J. Respir. Cell Mol. Biol. 12:27-32(1995). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Wistar; TISSUE=Pituitary; RA Chen Z.P., Krull N., Xu S., Levy A., Lightman S.L.; RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RC STRAIN=Wistar; RX MEDLINE=98099857; PubMed=9437211; RA Seye C.I., Gadeau A.P., Daret D., Dupuch F., Alzieu P., Capron L., RA Desgranges C.; RT "Overexpression of P2Y2 purinoceptor in intimal lesions of the rat RT aorta."; RL Arterioscler. Thromb. Vasc. Biol. 17:3602-3610(1997). CC -!- FUNCTION: Receptor for ATP and UTP coupled to G-proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP CC = ADP. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U09402; AAA61565.1; -. DR EMBL; L46865; AAB02099.1; -. DR EMBL; U56839; AAC00048.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 32 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 33 59 1 (POTENTIAL). FT DOMAIN 60 70 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 71 93 2 (POTENTIAL). FT DOMAIN 94 110 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 111 129 3 (POTENTIAL). FT DOMAIN 130 152 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 153 172 4 (POTENTIAL). FT DOMAIN 173 194 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 195 220 5 (POTENTIAL). FT DOMAIN 221 245 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 246 268 6 (POTENTIAL). FT DOMAIN 269 286 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 287 308 7 (POTENTIAL). FT DOMAIN 309 374 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 9 9 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 13 13 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 106 183 BY SIMILARITY. FT CONFLICT 132 132 C -> S (IN REF. 1). FT CONFLICT 143 143 S -> R (IN REF. 1). FT CONFLICT 166 166 A -> T (IN REF. 1). FT CONFLICT 188 188 A -> D (IN REF. 1). SQ SEQUENCE 374 AA; 42137 MW; 2DA6853AA20A1AF3 CRC64; MAAGLDSWNS TINGTWEGDE LGYKCRFNED FKYVLLPVSY GVVCVLGLCL NVVALYIFLC RLKTWNASTT YMFHLAVSDS LYAASLPLLV YYYAQGDHWP FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLH SLSWGHARYA RRVAAVVWVL VLACQAPVLY FVTTSVRGTR ITCHDTSARE LFSHFVAYSS VMLGLLFAVP FSIILVCYVL MARRLLKPAY GTTGLPRAKR KSVRTIALVL AVFALCFLPF HVTRTLYYSF RSLDLSCHTL NAINMAYKIT RPLASANSCL DPVLYFLAGQ RLVRFARDAK PATEPTPSPQ ARRKLGLHRP NRTDTVRKDL SISSDDSRRT ESTPAGSETK DIRL // ID P2Y4_MOUSE STANDARD; PRT; 361 AA. AC Q9JJS7; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE P2Y purinoceptor 4 (P2Y4). GN P2RY4 OR P2Y4R. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=129/SvJ; RX MEDLINE=21185993; PubMed=11290369; RA Suarez-Huerta N., Pouillon V., Boeynaems J.-M., Robaye B.; RT "Molecular cloning and characterization of the mouse P2Y4 nucleotide RT receptor."; RL Eur. J. Pharmacol. 416:197-202(2001). CC -!- FUNCTION: Receptor for ATP and UTP coupled to G-proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in the liver, intestine, stomach, CC bladder and lung. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AJ277752; CAB91043.1; -. DR HSSP; P34996; 1DDD. DR MGD; MGI:1926594; P2ry4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 30 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 31 58 1 (POTENTIAL). FT DOMAIN 59 68 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 69 91 2 (POTENTIAL). FT DOMAIN 92 108 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 109 127 3 (POTENTIAL). FT DOMAIN 128 149 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 150 170 4 (POTENTIAL). FT DOMAIN 171 192 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 193 218 5 (POTENTIAL). FT DOMAIN 219 242 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 243 265 6 (POTENTIAL). FT DOMAIN 266 283 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 284 305 7 (POTENTIAL). FT DOMAIN 306 361 CYTOPLASMIC (POTENTIAL). FT DISULFID 104 181 BY SIMILARITY. FT CARBOHYD 175 175 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 361 AA; 41034 MW; 3E8EA84B65BC0A20 CRC64; MTSADSLLFT SLGPSPSSGD GDCKFNEEFK FILLPLSYAV VFVLGLALNA PTLWLFLFRL RPWDATATYM FHLALSDTLY VLSLPTLVYY YAARNHWPFG TGFCKFVRFL FYWNLYCSVL FLTCISVHRY MGICHPLRAI RWGRPRFAGL LCLGVWLVVA GCLVPNLFFV TTNANGTTIL CHDTTLPEEF DHYVYFSSTI MVLLFGFPFL ITLVCYGLMA RRLYRPLPGA GQSSSRLRSL RTIAVVLTVF AVCFVPFHIT RTIYYLARLL NAECRVLNIV NVVYKVTRPL ASANSCLDPV LYLFTGDKYR NQLQQLCRGS TPKRRTTASS LALVTLHEES ISRWADIHQD SIFPAYEGDR L // ID AA2B_MOUSE STANDARD; PRT; 332 AA. AC Q60614; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Adenosine A2b receptor. GN ADORA2B. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BALB/c; TISSUE=Bone marrow; RX MEDLINE=94209670; PubMed=8157966; RA Marquardt D.L., Walker L.L., Heinemann S.; RT "Cloning of two adenosine receptor subtypes from mouse bone marrow- RT derived mast cells."; RL J. Immunol. 152:4508-4515(1994). CC -!- FUNCTION: RECEPTOR FOR ADENOSINE. THE ACTIVITY OF THIS RECEPTOR CC IS MEDIATED BY G PROTEINS WHICH ACTIVATE ADENYLYL CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U05673; AAA19001.1; -. DR PIR; I48933; I48933. DR HSSP; P29274; 1MMH. DR MGD; MGI:99403; Adora2b. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 8 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 9 31 1 (POTENTIAL). FT DOMAIN 32 44 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 45 67 2 (POTENTIAL). FT DOMAIN 68 78 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 79 101 3 (POTENTIAL). FT DOMAIN 102 121 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 122 144 4 (POTENTIAL). FT DOMAIN 145 178 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 179 203 5 (POTENTIAL). FT DOMAIN 204 235 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 236 259 6 (POTENTIAL). FT DOMAIN 260 267 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 268 291 7 (POTENTIAL). FT DOMAIN 292 332 CYTOPLASMIC (POTENTIAL). FT DISULFID 78 171 BY SIMILARITY. FT CARBOHYD 153 153 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 163 163 N-LINKED (GLCNAC...) (POTENTIAL). FT LIPID 311 311 S-palmitoyl cysteine (Potential). SQ SEQUENCE 332 AA; 36064 MW; C8A3108371AD1C1C CRC64; MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA TADVAVGLFA IPFAITISLG FCTDFHGCLF LACFVLVLTQ SSIFSLLAVA VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDSA TSNCTELGDG IANKSCCPLT CLFENVVPMS YMVYFNFFGC VLPPLLIMLV IYIKIFMVAC KQLQSMELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS FHKIISRYVL CQAETKGGSG QAGAQSTLSL GL // ID AA2B_CHICK STANDARD; PRT; 340 AA. AC O13076; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Adenosine A2b receptor. GN ADORA2B. OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=SPAFAS; RX MEDLINE=97386507; PubMed=9244356; RA Worpenberg S., Burk O., Klempnauer K.H.; RT "The chicken adenosine receptor 2B gene is regulated by v-myb."; RL Oncogene 15:213-221(1997). CC -!- FUNCTION: RECEPTOR FOR ADENOSINE. THE ACTIVITY OF THIS RECEPTOR CC IS MEDIATED BY G PROTEINS WHICH ACTIVATE ADENYLYL CYCLASE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; Y12601; CAA73173.1; -. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 6 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 7 29 1 (POTENTIAL). FT DOMAIN 30 42 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 43 65 2 (POTENTIAL). FT DOMAIN 66 76 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 77 99 3 (POTENTIAL). FT DOMAIN 100 119 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 120 142 4 (POTENTIAL). FT DOMAIN 143 178 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 179 203 5 (POTENTIAL). FT DOMAIN 204 235 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 236 259 6 (POTENTIAL). FT DOMAIN 260 267 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 268 291 7 (POTENTIAL). FT DOMAIN 292 340 CYTOPLASMIC (POTENTIAL). FT DISULFID 76 171 BY SIMILARITY. FT LIPID 310 310 S-palmitoyl cysteine (Potential). FT CARBOHYD 151 151 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 154 154 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 340 AA; 37772 MW; 2DAC18E6DC6A950F CRC64; MNTMKTTYIV LELIIAVLSI AGNVLVCWAV AINSTLKNAT NYFLVSLAVA DIAVGLLAIP FAITISIGFQ VDFHSCLFFA CFVLVLTQSS IFSLLAVAID RYLAIKIPLR YNSLVTGKRA RGLIAVLWLL SFVIGLTPLM GWNKAMSGCP NSTNETGADH GAGHHGCFIS CLFENVVTMS YMVYFNFFGC VLLPLIIMLG IYIKIFMVAC KQLHQIELMG NSRTTLQKEV HAAKSLAIIV GLFAFCWLPL HILNCITHFH EEFSKSKPEW VMYVAIILSH ANSVINPIIY AYRIRDFRYT FHKIISKILC KTDDFPKCTT DNNQHLTVTN VNAPAASVTI // ID AA3R_RAT STANDARD; PRT; 320 AA. AC P28647; Q63792; DT 01-DEC-1992 (Rel. 24, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Adenosine A3 receptor (TGPCR1). GN ADORA3. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. (ISOFORM A), AND CHARACTERIZATION. RC TISSUE=Brain; RX MEDLINE=92366475; PubMed=1323836; RA Zhou Q.Y., Li C.Y., Olah M.E., Johnson R.A., Stiles G.L., Civelli O.; RT "Molecular cloning and characterization of an adenosine receptor: the RT A3 adenosine receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 89:7432-7436(1992). RN [2] RP SEQUENCE FROM N.A. (ISOFORM A). RC STRAIN=Wistar; TISSUE=Testis; RX MEDLINE=91285122; PubMed=1647979; RA Meyerhof W., Mueller-Brechlin R., Richter D.; RT "Molecular cloning of a novel putative G-protein coupled receptor RT expressed during rat spermiogenesis."; RL FEBS Lett. 284:155-160(1991). RN [3] RP SEQUENCE FROM N.A. (ISOFORM B). RC TISSUE=Brain; RX MEDLINE=96196578; PubMed=8612733; RA Sajjadi F.G., Boyle D.L., Domingo R.C., Firestein G.S.; RT "cDNA cloning and characterization of A3i, an alternatively spliced RT rat A3 adenosine receptor variant."; RL FEBS Lett. 382:125-129(1996). CC -!- FUNCTION: RECEPTOR FOR ADENOSINE. THE ACTIVITY OF THIS RECEPTOR IS CC MEDIATED BY G PROTEINS WHICH INHIBITS ADENYLYL CYCLASE. POSSIBLE CC ROLE IN REPRODUCTION. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=A; CC IsoId=P28647-1; Sequence=Displayed; CC Name=B; Synonyms=A3i; CC IsoId=P28647-2; Sequence=VSP_001859; CC -!- TISSUE SPECIFICITY: TESTIS, PARTICULARLY IN SPERMATOCYTES AND CC SPERMATIDS BUT NOT IN SPERMATOGONIA. LOW LEVELS IN THE BRAIN. CC -!- DEVELOPMENTAL STAGE: EXPRESSED DURING SPERMIOGENESIS. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X59249; CAA41937.1; -. DR EMBL; M94152; AAA40680.1; -. DR EMBL; X93219; CAA63702.1; -. DR PIR; A46152; A46152. DR PIR; S17177; S17177. DR HSSP; P29274; 1MMH. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate; Alternative splicing. FT DOMAIN 1 16 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 17 39 1 (POTENTIAL). FT DOMAIN 40 50 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 51 74 2 (POTENTIAL). FT DOMAIN 75 86 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 87 108 3 (POTENTIAL). FT DOMAIN 109 128 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 129 150 4 (POTENTIAL). FT DOMAIN 151 179 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 180 200 5 (POTENTIAL). FT DOMAIN 201 233 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 234 257 6 (POTENTIAL). FT DOMAIN 258 263 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 264 286 7 (POTENTIAL). FT DOMAIN 287 320 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 85 168 BY SIMILARITY. FT LIPID 305 305 S-palmitoyl cysteine (Potential). FT VARSPLIC 119 119 R -> RLSFLVVNLPFSSPHSNR (in isoform B). FT /FTId=VSP_001859. FT CONFLICT 18 18 I -> V (IN REF. 1). FT CONFLICT 68 68 I -> V (IN REF. 3). FT CONFLICT 74 83 VSLEVQMHFY -> SAWRSRCTSM (IN REF. 2). FT CONFLICT 132 132 F -> L (IN REF. 3). FT CONFLICT 172 172 S -> F (IN REF. 1). FT CONFLICT 288 288 I -> N (IN REF. 1). FT CONFLICT 291 295 FKETY -> VQRNH (IN REF. 1). SQ SEQUENCE 320 AA; 36629 MW; 59DBA40C594ACDAB CRC64; MKANNTTTSA LWLQITYITM EAAIGLCAVV GNMLVIWVVK LNRTLRTTTF YFIVSLALAD IAVGVLVIPL AIAVSLEVQM HFYACLFMSC VLLVFTHASI MSLLAIAVDR YLRVKLTVRY RTVTTQRRIW LFLGLCWLVS FLVGLTPMFG WNRKVTLELS QNSSTLSCHF RSVVGLDYMV FFSFITWILI PLVVMCIIYL DIFYIIRNKL SQNLTGFRET RAFYGREFKT AKSLFLVLFL FALCWLPLSI INFVSYFNVK IPEIAMCLGI LLSHANSMMN PIVYACKIKK FKETYFVILR ACRLCQTSDS LDSNLEQTTE // ID AA3R_MOUSE STANDARD; PRT; 319 AA. AC Q61618; Q9R202; DT 15-JUL-1998 (Rel. 36, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Adenosine 3 receptor (A3AR). GN ADORA3 OR GPCR2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99208672; PubMed=10191095; RA Zhao Z., Francis C., Ravid K.; RT "Characterization of the mouse A3 adenosine receptor gene: exon/intron RT organization and promoter activity."; RL Genomics 57:152-155(1999). RN [2] RP SEQUENCE OF 111-239 FROM N.A. RC TISSUE=Testis; RX MEDLINE=94116980; PubMed=8288218; RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., RA Copeland N.G., Jenkins N.A.; RT "Identification, chromosomal location, and genome organization of RT mammalian G-protein-coupled receptors."; RL Genomics 18:175-184(1993). CC -!- FUNCTION: RECEPTOR FOR ADENOSINE. THE ACTIVITY OF THIS RECEPTOR CC IS MEDIATED BY G PROTEINS WHICH INHIBITS ADENYLYL CYCLASE. CC POSSIBLE ROLE IN REPRODUCTION. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF069778; AAC82643.1; -. DR EMBL; L20331; AAA16851.1; -. DR PIR; B48909; B48909. DR MGD; MGI:104847; Adora3. DR GO; GO:0005887; C:integral to plasma membrane; IMP. DR GO; GO:0001613; F:A3 adenosine receptor activity, G-protein c...; IMP. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Lipoprotein; Palmitate. FT DOMAIN 1 15 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 16 38 1 (POTENTIAL). FT DOMAIN 39 49 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 50 73 2 (POTENTIAL). FT DOMAIN 74 85 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 86 107 3 (POTENTIAL). FT DOMAIN 108 127 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 128 149 4 (POTENTIAL). FT DOMAIN 150 178 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 179 199 5 (POTENTIAL). FT DOMAIN 200 232 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 233 256 6 (POTENTIAL). FT DOMAIN 257 262 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 263 285 7 (POTENTIAL). FT DOMAIN 286 319 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 13 13 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 161 161 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 84 167 BY SIMILARITY. FT LIPID 304 304 S-palmitoyl cysteine (Potential). FT CONFLICT 184 184 I -> V (IN REF. 2). FT CONFLICT 196 196 I -> V (IN REF. 2). FT CONFLICT 214 214 T -> S (IN REF. 2). SQ SEQUENCE 319 AA; 36448 MW; 6AD7F46A9F03D9CC CRC64; MEADNTTETD WLNITYITME AAIGLCAVVG NMLVIWVVKL NPTLRTTTVY FIVSLALADI AVGVLVIPLA IAVSLQVKMH FYACLFMSCV LLIFTHASIM SLLAIAVHRY LRVKLTVRYR TVTTQRRIWL FLGLCWLVSF LVGLTPMFGW NRKATLASSQ NSSTLLCHFR SVVSLDYMVF FSFITWILVP LVVMCIIYLD IFYIIRNKLS QNLTGFRETR AFYGREFKTA KSLFLVLFLF ALCWLPLSII NFVSYFDVKI PDVAMCLGIL LSHANSMMNP IVYACKIKKF KETYFLILRA VRLCQTSDSL DSNMEQTTE // ID P2Y6_MOUSE STANDARD; PRT; 328 AA. AC Q9ERK9; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE P2Y purinoceptor 6 (P2Y6). GN P2RY6. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=129/SvEv; RX MEDLINE=21160052; PubMed=11259526; RA Lazarowski E.R., Rochelle L.G., O'Neal W.K., Ribeiro C.M.P., RA Grubb B.R., Zhang V., Harden T.K., Boucher R.C.; RT "Cloning and functional characterization of two murine uridine RT nucleotide receptors reveal a potential target for correcting ion RT transport deficiency in cystic fibrosis gallbladder."; RL J. Pharmacol. Exp. Ther. 297:43-49(2001). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for extracellular UTP > ADP = 2-methylthio-ATP CC > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is CC mediated by G proteins which activate a phosphatidylinositol- CC calcium second messenger system. Functionally coupled to CC phospholipase C (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF298899; AAG24619.1; -. DR EMBL; BC027331; AAH27331.1; -. DR MGD; MGI:2673874; P2ry6. DR GO; GO:0019103; F:pyrimidine nucleotide binding; IC. DR GO; GO:0045029; F:UDP-activated nucleotide receptor activity; IDA. DR GO; GO:0030321; P:transepithelial chloride transport; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT DOMAIN 49 62 Cytoplasmic (Potential). FT TRANSMEM 63 83 2 (Potential). FT DOMAIN 84 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT DOMAIN 123 144 Cytoplasmic (Potential). FT TRANSMEM 145 165 4 (Potential). FT DOMAIN 166 194 Extracellular (Potential). FT TRANSMEM 195 215 5 (Potential). FT DOMAIN 216 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT DOMAIN 258 280 Extracellular (Potential). FT TRANSMEM 281 303 7 (Potential). FT DOMAIN 304 328 Extracellular (Potential). FT DISULFID 99 177 By similarity. FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 173 173 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 328 AA; 36721 MW; 00F9DF5ADADF903E CRC64; MEQDNGTIQA PGLPPTTCVY REDFKRLLLT PVYSVVLVVG LPLNICVIAQ ICASRRTLTR SAVYTLNLAL ADLMYACSLP LLIYNYARGD HWPFGDLACR FVRFLFYANL HGSILFLTCI SFQRYLGICH PLASWHKRGG RRAAWVVCGV VWLAVTAQCL PTAVFAATGI QRNRTVCYDL SPPILSTRYL PYGMALTVIG FLLPFIALLA CYCRMARRLC RQDGPAGPVA QERRSKAARM AVVVAAVFAI SFLPFHITKT AYLAVRSTPG VSCPVLETFA AAYKGTRPFA SVNSVLDPIL FYFTQQKFRR QPHDLLQRLT AKWQRQRV // ID GP92_HUMAN STANDARD; PRT; 372 AA. AC Q9H1C0; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Probable G protein-coupled receptor GPR92. GN GPR92 OR GPR93. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20517346; PubMed=11062477; RA White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., RA Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.; RT "Autosomal dominant hypophosphataemic rickets is associated with RT mutations in FGF23."; RL Nat. Genet. 26:345-348(2000). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21458557; PubMed=11574155; RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.; RT "Discovery and mapping of ten novel G protein-coupled receptor RT genes."; RL Gene 275:83-91(2001). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=22040266; PubMed=12044878; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=B-cell; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Not expressed in frontal cortex, basal CC forebrain, caudate putamen, thalamus, or hippocampus. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AJ272207; CAC03715.1; -. DR EMBL; AF411112; AAL26483.1; -. DR EMBL; AB083600; BAB89313.1; -. DR EMBL; BC033571; AAH33571.1; -. DR Genew; HGNC:13307; GPR92. DR MIM; 606926; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 26 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 27 47 1 (POTENTIAL). FT DOMAIN 48 55 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 56 76 2 (POTENTIAL). FT DOMAIN 77 96 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 97 117 3 (POTENTIAL). FT DOMAIN 118 136 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 137 157 4 (POTENTIAL). FT DOMAIN 158 187 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 188 208 5 (POTENTIAL). FT DOMAIN 209 239 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 240 260 6 (POTENTIAL). FT DOMAIN 261 276 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 277 297 7 (POTENTIAL). FT DOMAIN 298 372 CYTOPLASMIC (POTENTIAL). FT DISULFID 94 175 BY SIMILARITY. FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 9 9 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 372 AA; 41346 MW; BA35709084BB6D84 CRC64; MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA LRVHSVVSVY MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI FQMNMYGSCI FLMLINVDRY AAIVHPLRLR HLRRPRVARL LCLGVWALIL VFAVPAARVH RPSRCRYRDL EVRLCFESFS DELWKGRLLP LVLLAEALGF LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL VIFLLCFVPY NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG LLRPSDSHSL SSFTQCPQDS AL // ID GP91_MOUSE STANDARD; PRT; 317 AA. AC Q99MT6; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Probable G protein-coupled receptor GPR91. GN GPR91. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A., AND TISSUE SPECIFICITY. RC STRAIN=C57BL/6; RX MEDLINE=21172992; PubMed=11273702; RA Wittenberger T., Schaller H.C., Hellebrand S.; RT "An expressed sequence tag (EST) data mining strategy succeeding in RT the discovery of new G-protein coupled receptors."; RL J. Mol. Biol. 307:799-813(2001). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in liver and kidney. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF295367; AAK01867.1; -. DR MGD; MGI:1934135; Gpr91. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 23 Extracellular (Potential). FT TRANSMEM 24 47 1 (Potential). FT DOMAIN 48 55 Cytoplasmic (Potential). FT TRANSMEM 56 76 2 (Potential). FT DOMAIN 77 101 Extracellular (Potential). FT TRANSMEM 102 119 3 (Potential). FT DOMAIN 120 133 Cytoplasmic (Potential). FT TRANSMEM 134 157 4 (Potential). FT DOMAIN 158 180 Extracellular (Potential). FT TRANSMEM 181 204 5 (Potential). FT DOMAIN 205 228 Cytoplasmic (Potential). FT TRANSMEM 229 246 6 (Potential). FT DOMAIN 247 277 Extracellular (Potential). FT TRANSMEM 278 294 7 (Potential). FT DOMAIN 295 317 Cytoplasmic (Potential). FT DISULFID 91 168 By similarity. FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 36701 MW; 4E22F0608F928E36 CRC64; MAQNLSCENW LATEAILNKY YLSAFYAIEF IFGLLGNVTV VFGYLFCMKN WNSSNVYLFN LSISDFAFLC TLPILIKSYA NDKGTYGDVL CISNRYVLHT NLYTSMLLLT VISMDRYLLM KYPFREHFLQ KKEFAILISL AVWALVTLEV LPMLTFINSV PKEEGSNCID YASSGNPEHN LIYSLCLTLL GFLIPLSVMC FFYYKMVVFL KRRSQQQATA LPLDKPQRLV VLAVVIFSIL FTPYHIMRNL RIASRLDSWP QGCTQKAIKS IYTLTRPLAF LNSAINPIFY FLMGDHYREM LISKFRQYFK SLTSFRT // ID GRHR_RAT STANDARD; PRT; 327 AA. AC P30969; DT 01-JUL-1993 (Rel. 26, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). GN GNRHR. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Pituitary; RX MEDLINE=93246029; PubMed=1338727; RA Eidne K.A., Sellar R.E., Couper G., Anderson L., Taylor P.L.; RT "Molecular cloning and characterisation of the rat pituitary RT gonadotropin-releasing hormone (GnRH) receptor."; RL Mol. Cell. Endocrinol. 90:R5-R9(1992). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Buffalo; TISSUE=Pituitary; RA Kakar S.S., Grantham K., Musgrove L.C., Devor D.C., Sellers J.C., RA Neill J.D.; RL Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Pituitary; RX MEDLINE=93221478; PubMed=7916600; RA Perrin M.H., Bilezikjian L.M., Hoeger C., Donaldson C.J., Rivier J., RA Haas Y., Vale W.W.; RT "Molecular and functional characterization of GnRH receptors cloned RT from rat pituitary and a mouse pituitary tumor cell line."; RL Biochem. Biophys. Res. Commun. 191:1139-1144(1993). RN [4] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Pituitary; RX MEDLINE=93129239; PubMed=1339279; RA Kaiser U.B., Zhao D., Cardona G.R., Chin W.W.; RT "Isolation and characterization of cDNAs encoding the rat pituitary RT gonadotropin-releasing hormone receptor."; RL Biochem. Biophys. Res. Commun. 189:1645-1652(1992). RN [5] RP SEQUENCE FROM N.A. RC TISSUE=Gonad; RX MEDLINE=94241995; PubMed=8185587; RA Moumni M., Kottler M.L., Counis R.; RT "Nucleotide sequence analysis of mRNAs predicts that rat pituitary RT and gonadal gonadotropin-releasing hormone receptor proteins have RT identical primary structure."; RL Biochem. Biophys. Res. Commun. 200:1359-1366(1994). RN [6] RP SEQUENCE FROM N.A. RX MEDLINE=94122663; PubMed=7764374; RA Kudo A., Park M.K., Kawashima S.; RT "Isolation of rat GnRH receptor cDNA having different 5'-noncoding RT sequence."; RL Zool. Sci. 10:863-867(1993). RN [7] RP SEQUENCE FROM N.A. RA Reinhart J., Xiao S., Arora K.K., Catt K.J.; RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that CC mediate the action of GnRH to stimulate the secretion of the CC gonadotropic hormones (LH and FSH). This receptor mediates its CC action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X68980; CAA48776.1; -. DR EMBL; S59525; AAB26420.1; -. DR EMBL; U00935; AAC27349.1; -. DR EMBL; L25053; AAA41265.1; ALT_INIT. DR EMBL; L07646; AAA41274.1; -. DR EMBL; X76635; CAA54083.1; -. DR EMBL; S68578; AAC60671.1; -. DR EMBL; U92471; AAB58038.1; -. DR EMBL; U92469; AAB58038.1; JOINED. DR EMBL; U92470; AAB58038.1; JOINED. DR PIR; S29332; S29332. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 58 1 (POTENTIAL). FT DOMAIN 59 77 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 78 97 2 (POTENTIAL). FT DOMAIN 98 115 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 116 137 3 (POTENTIAL). FT DOMAIN 138 164 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 165 184 4 (POTENTIAL). FT DOMAIN 185 211 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 212 231 5 (POTENTIAL). FT DOMAIN 232 280 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 281 299 6 (POTENTIAL). FT DOMAIN 300 305 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 306 325 7 (POTENTIAL). FT DOMAIN 326 327 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 102 102 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 114 195 BY SIMILARITY. FT CONFLICT 184 184 A -> V (IN REF. 1). FT CONFLICT 272 272 G -> A (IN REF. 3, 5, 6 AND 7). FT CONFLICT 311 311 A -> G (IN REF. 1). SQ SEQUENCE 327 AA; 37748 MW; 86A2CA1A2C9F1BE4 CRC64; MANNASLEQD QNHCSAINNS IPLTQGKLPT LTLSGKIRVT VTFFLFLLST AFNASFLVKL QRWTQKRKKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG EFLCKVLSYL KLFSMYAPAF MMVVISLDRS LAVTQPLAVQ SKSKLERSMT SLAWILSIVF AGPQLYIFRM IYLADGSGPA VFSQCVTHCS FPQWWHEAFY NFFTFSCLFI IPLLIMLICN AKIIFALTRV LHQDPRKLQL NQSKNNIPRA RLRTLKMTVA FGTSFVICWT PYYVLGIWYW FDPEMLNRVS EPVNHFFFLF AFLNPCFDPL IYGYFSL // ID GRR2_CALJA STANDARD; PRT; 380 AA. AC Q95MG6; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Gonadotropin-releasing hormone II receptor (Type II GnRH receptor) DE (GnRH-II-R). GN GNRHR2. OS Callithrix jacchus (Common marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Platyrrhini; Callitrichidae; OC Callithrix. OX NCBI_TaxID=9483; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21396534; PubMed=11493674; RA Millar R., Lowe S., Conklin D., Pawson A., Maudsley S., Troskie B., RA Ott T., Millar M., Lincoln G., Sellar R., Faurholm B., Scobie G., RA Kuestner R., Terasawa E., Katz A.; RT "A novel mammalian receptor for the evolutionarily conserved type II RT GnRH."; RL Proc. Natl. Acad. Sci. U.S.A. 98:9636-9641(2001). CC -!- FUNCTION: Receptor for gonadotropin releasing hormone II (GnRH CC II). This receptor mediates its action by association with G CC proteins that activate a phosphatidylinositol-calcium second CC messenger system. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Phosphorylated on the C-terminal cytoplasmic tail (Probable). CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF368286; AAK60927.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation. FT DOMAIN 1 40 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 41 60 1 (POTENTIAL). FT DOMAIN 61 76 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 77 96 2 (POTENTIAL). FT DOMAIN 97 114 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 115 136 3 (POTENTIAL). FT DOMAIN 137 160 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 161 178 4 (POTENTIAL). FT DOMAIN 179 204 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 205 224 5 (POTENTIAL). FT DOMAIN 225 278 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 279 297 6 (POTENTIAL). FT DOMAIN 298 303 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 304 323 7 (POTENTIAL). FT DOMAIN 324 380 CYTOPLASMIC (POTENTIAL). FT DISULFID 113 188 BY SIMILARITY. FT CARBOHYD 101 101 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 380 AA; 41991 MW; 110637D5ACFA0B1C CRC64; MSAVNGTPWG SSAREEVWAG SGVEVEGSEL PTFSTAAKVR VGVTIVLFVS SAGGNLAVLW SVTRPQPSQL RPSPVRRLFA HLAAADLLVT FVVMPLDATW NITVQWLAGD IACRTLMFLK LMAMYAAAFL PVVIGLDRQA AVLNPLGSRS GVRKLLGAAW GLSFLLALPQ LFLFHTVHRA GPVPFTQCAT KGSFKARWQE TTYNLFTFCC LFLLPLTAMA ICYSRIVLGV SSPRTRKGSH APAGEFALRR SFDNRPRVRL RALRLALLVL LTFILCWTPY YLLGLWYWFS PSMLSEVPPS LSHILFLFGL LNAPLDPLLY GAFTLGCRRG HQELSMDSSR EEGSRRMFQQ DIQALRQTEV QKTVTSRKAG ETKDIPITSI // ID GHSR_PIG STANDARD; PRT; 366 AA. AC Q95254; Q95255; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing DE peptide receptor) (GHRP) (Ghrelin receptor). GN GHSR. OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823; RN [1] RP SEQUENCE FROM N.A. (ISOFORMS 1A AND 1B). RC STRAIN=Yorkshire; TISSUE=Pituitary; RX MEDLINE=96337998; PubMed=8688086; RA Howard A.D., Feighner S.D., Cully D.F., Arena J.P., RA Liberator P.A., Rosenblum C.I., Hamelin M., Hreniuk D.L., RA Palyha O.C., Anderson J., Paress P.S., Diaz C., Chou M., Liu K.K., RA McKee K.K., Pong S.-S., Chaung L.-Y., Elbrecht A., Dashkevicz M., RA Heavens R., Rigby M., Sirinathsinghji D.J.S., Dean D.C., Melillo D.G., RA Patchett A.A., Nargund R., Griffin P.R., Demartino J.A., Gupta S.K., RA Schaeffer J.M., Smith R.G., van der Ploeg L.H.T.; RT "A receptor in pituitary and hypothalamus that functions in growth RT hormone release."; RL Science 273:974-977(1996). CC -!- FUNCTION: Receptor for ghrelin, coupled to G-alpha-11 proteins. CC Stimulates growth hormone secretion. Binds also other growth CC hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) CC as well as non-peptide, low molecular weight secretagogues (e.g. CC L-692,429, MK-0677, adenosine). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: 2 isoforms; 1A (shown here) and 1B; are CC produced by alternative splicing. Isoform 1B appears not to bind CC secretagogues. CC -!- TISSUE SPECIFICITY: PITUITARY AND HYPOTHALAMUS. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U60178; AAC48630.1; -. DR EMBL; U60180; AAC48631.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Alternative splicing. FT DOMAIN 1 40 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 41 66 1 (POTENTIAL). FT DOMAIN 67 72 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 73 96 2 (POTENTIAL). FT DOMAIN 97 117 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 118 139 3 (POTENTIAL). FT DOMAIN 140 162 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 163 183 4 (POTENTIAL). FT DOMAIN 184 211 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 212 235 5 (POTENTIAL). FT DOMAIN 236 263 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 264 285 6 (POTENTIAL). FT DOMAIN 286 302 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 303 326 7 (POTENTIAL). FT DOMAIN 327 366 CYTOPLASMIC (POTENTIAL). FT DISULFID 116 198 BY SIMILARITY. FT CARBOHYD 13 13 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 27 27 N-LINKED (GLCNAC...) (POTENTIAL). FT VARSPLIC 266 289 AVVVFAFILCWLPFHVGRYLFSKS -> GGSQCALELSLPG FT PLHSSCLFSSP (IN ISOFORM 1B). FT VARSPLIC 290 366 MISSING (IN ISOFORM 1B). SQ SEQUENCE 366 AA; 41194 MW; 2C850B3EF61B7C1C CRC64; MWNATPSEEP GPNLTLPDLG WDAPPENDSL VEELLPLFPT PLLAGVTATC VALFVVGIAG NLLTMLVVSR FREMRTTTNL YLSSMAFSDL LIFLCMPLDL FRLWQYRPWN LGNLLCKLFQ FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVILVIWAV AFCSAGPIFV LVGVEHDNGT DPRDTNECRA TEFAVRSGLL TVMVWVSSVF FFLPVFCLTV LYSLIGRKLW RRKRGEAAVG SSLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSL EPGSVEIAQI SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFKLLGF EPFSQRKLST LKDESSRAWT ESSINT // ID MTLR_HUMAN STANDARD; PRT; 412 AA. AC O43193; DT 15-DEC-1998 (Rel. 37, Created) DT 15-DEC-1998 (Rel. 37, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Motilin receptor (G protein-coupled receptor 38). GN MLNR OR GPR38 OR MTLR1 OR MTLR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM A). RX MEDLINE=98110578; PubMed=9441746; RA McKee K.K., Tan C.P., Palyha O.C., Liu J., Feighner S.D., RA Hreniuk D.L., Smith R.G., Howard A.D., van der Ploeg L.H.T.; RT "Cloning and characterization of two human G protein-coupled receptor RT genes (GPR38 and GPR39) related to the growth hormone secretagogue RT and neurotensin receptors."; RL Genomics 46:426-434(1997). RN [2] RP SEQUENCE FROM N.A. (ISOFORMS A AND B). RX MEDLINE=99316084; PubMed=10381885; RA Feighner S.D., Tan C.P., McKee K.K., Palyha O.C., Hreniuk D.L., RA Pong S.-S., Austin C.P., Figueroa D., MacNeil D., Cascieri M.A., RA Nargund R., Bakshi R., Abramovitz M., Stocco R., Kargman S., RA O'Neill G., van Der Ploeg L.H.T., Evans J., Patchett A.A., Smith R.G., RA Howard A.D.; RT "Receptor for motilin identified in the human gastrointestinal RT system."; RL Science 284:2184-2188(1999). RN [3] RP SEQUENCE FROM N.A. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R., RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [4] RP FUNCTION. RX MEDLINE=21219832; PubMed=11322507; RA Smith R.G., Leonard R., Bailey A.R.T., Palyha O.C., Feighner S.D., RA Tan C.P., Mckee K.K., Pong S.-S., Griffin P.R., Howard A.D.; RT "Growth hormone secretagogue receptor family members and ligands."; RL Endocrine 14:9-14(2001). CC -!- FUNCTION: Receptor for motilin. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=A; CC IsoId=O43193-1; Sequence=Displayed; CC Name=B; CC IsoId=O43193-2; Sequence=VSP_001894; CC -!- TISSUE SPECIFICITY: Expressed only in thyroid, stomach, and bone CC marrow. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF034632; AAC26081.1; -. DR EMBL; AL137000; CAC19107.1; -. DR Genew; HGNC:4495; MLNR. DR MIM; 602885; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007586; P:digestion; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Alternative splicing. FT DOMAIN 1 35 Extracellular (Potential). FT TRANSMEM 36 56 1 (Potential). FT DOMAIN 57 74 Cytoplasmic (Potential). FT TRANSMEM 75 94 2 (Potential). FT DOMAIN 95 112 Extracellular (Potential). FT TRANSMEM 113 134 3 (Potential). FT DOMAIN 135 157 Cytoplasmic (Potential). FT TRANSMEM 158 178 4 (Potential). FT DOMAIN 179 246 Extracellular (Potential). FT TRANSMEM 247 270 5 (Potential). FT DOMAIN 271 298 Cytoplasmic (Potential). FT TRANSMEM 299 320 6 (Potential). FT DOMAIN 321 334 Extracellular (Potential). FT TRANSMEM 335 358 7 (Potential). FT DOMAIN 359 412 Cytoplasmic (Potential). FT DISULFID 111 235 By similarity. FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 192 192 N-linked (GlcNAc...) (Potential). FT VARSPLIC 301 412 LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVAL FT QLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHR FT SRDTAGEVAGDTGGDTVGYTETSANVKTMG -> RKWSRRG FT SKDACLQSAPPGTAQTLGPLPLLAQLWAPLPAPFPISIPAS FT TRRGGGSGIYNLLVALPRWQNHLHKHGRFADDVLLSVL FT (in isoform B). FT /FTId=VSP_001894. SQ SEQUENCE 412 AA; 45344 MW; C13FF6165012DEF3 CRC64; MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV VGVSGNVVTV MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR SRPWVFGPLL CRLSLYVGEG CTYATLLHMT ALSVERYLAI CRPLRARVLV TRRRVRALIA VLWAVALLSA GPFLFLVGVE QDPGISVVPG LNGTARIASS PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA QLGALRVMLW VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI NPILYNLISK KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG YTETSANVKT MG // ID ML1A_CHICK STANDARD; PRT; 353 AA. AC P49285; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE Melatonin receptor type 1A (MEL-1A-R) (CKA). OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=96073557; PubMed=7576645; RA Reppert S.M., Weaver D.R., Cassone V.M., Godson C., RA Kolakowski L.F. Jr.; RT "Melatonin receptors are for the birds: molecular analysis of two RT receptor subtypes differentially expressed in chick brain."; RL Neuron 15:1003-1015(1995). CC -!- FUNCTION: HIGH AFFINITY RECEPTOR FOR MELATONIN. THE ACTIVITY OF CC THIS RECEPTOR IS MEDIATED BY PERTUSSIS TOXIN SENSITIVE G PROTEINS CC THAT INHIBITS ADENYLATE CYCLASE ACTIVITY (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: EXPRESSED IN OPTIC TECTUM AND RETINA, LESS IN CC NEOSTRIATUM, HYPOTHALAMUS AND THALAMUS. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U31820; AAA92498.1; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 32 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 33 53 1 (POTENTIAL). FT DOMAIN 54 66 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 67 87 2 (POTENTIAL). FT DOMAIN 88 105 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 106 126 3 (POTENTIAL). FT DOMAIN 127 145 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 146 166 4 (POTENTIAL). FT DOMAIN 167 190 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 191 211 5 (POTENTIAL). FT DOMAIN 212 243 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 244 264 6 (POTENTIAL). FT DOMAIN 265 277 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 278 298 7 (POTENTIAL). FT DOMAIN 299 353 CYTOPLASMIC (POTENTIAL). FT DISULFID 103 180 BY SIMILARITY. FT CARBOHYD 4 4 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 9 9 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 353 AA; 39895 MW; DBF078C7F2AF291D CRC64; MRANGSELNG TVLPRDPPAE GSPRRPPWVT STLATILIFT IVVDLLGNLL VILSVYRNKK LRNAGNIFVV SLAIADLVVA IYPYPLVLTS VFHNGWNLGY LHCQISGFLM GLSVIGSIFN ITGIAINRYC YICHSLKYDK LYSDKNSLCY VGLIWVLTVV AIVPNLFVGS LQYDPRIYSC TFAQSVSSAY TIAVVFFHFI LPIAIVTYCY LRIWILVIQV RRRVKPDNNP RLKPHDFRNF VTMFVVFVLF AVCWAPLNFI GLAVAVDPET IIPRIPEWLF VSSYYMAYFN SCLNAIIYGL LNQNFRREYK KIVVSFCTAK AFFQDSSNDA ADRIRSKPSP LITNNNQVKV DSV // ID UL33_HCMVA STANDARD; PRT; 390 AA. AC P16849; DT 01-AUG-1990 (Rel. 15, Created) DT 01-AUG-1990 (Rel. 15, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE G-protein coupled receptor homolog UL33. GN UL33. OS Human cytomegalovirus (strain AD169). OC Viruses; dsDNA viruses, no RNA stage; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90269039; PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [2] RP SIMILARITY TO G-PROTEIN COUPLED RECEPTORS. RX MEDLINE=90231415; PubMed=2158627; RA Chee M.S., Satchwell S.C., Preddie E., Weston K.M., Barrell B.G.; RT "Human cytomegalovirus encodes three G protein-coupled receptor RT homologues."; RL Nature 344:774-777(1990). CC -!- FUNCTION: REGULATION OF HCMV LATENCY OR REACTIVATION?; POTENTIAL CC PATHWAY FOR VIRALLY TRANSFORMED CELL PROLIFERATION. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; X17403; CAA35432.1; -. DR EMBL; X53293; CAA37385.1; -. DR PIR; S09796; QQBET9. DR PIR; S09322; S09322. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane. FT DOMAIN 1 7 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 8 32 1 (POTENTIAL). FT DOMAIN 33 48 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 49 73 2 (POTENTIAL). FT DOMAIN 74 80 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 81 107 3 (POTENTIAL). FT DOMAIN 108 116 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 117 138 4 (POTENTIAL). FT DOMAIN 139 181 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 182 202 5 (POTENTIAL). FT DOMAIN 203 218 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 219 245 6 (POTENTIAL). FT DOMAIN 246 259 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 260 283 7 (POTENTIAL). FT DOMAIN 284 390 CYTOPLASMIC (POTENTIAL). SQ SEQUENCE 390 AA; 43804 MW; 7E0B02FCFAD90E17 CRC64; MTGPLFAIRT TEAVLNTFII FVGGPLNAIV LITQLLTNRV LGYSTPTIYM TNLYSTNFLT LTVLPFIVLS NQWLLPAGVA SCKFLSVIYY SSCTVGFATV ALIAADRYRV LHKRTYARQS YRSTYMILLL TWLAGLIFSV PAAVYTTVVM HHDANDTNNT NGHATCVLYF VAEEVHTVLL SWKVLLTMVW GAAPVIMMTW FYAFFYSTVQ RTSQKQRSRT LTFVSVLLIS FVALQTPYVS LMIFNSYATT AWPMQCEHLT LRRTIGTLAR VVPHLHCLIN PILYALLGHD FLQRMRQCFR GQLLDRRAFL RSQQNQRATA ETNLAAGNNS QSVATSLDTN SKNYNQHAKR SVSFNFPSGT WKGGQKTASN DTSTKIPHRL SQSHHNLSGV // ID EDG5_HUMAN STANDARD; PRT; 353 AA. AC O95136; Q86UN8; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Sphingosine 1-phosphate receptor Edg-5 (S1P receptor Edg-5) DE (Endothelial differentiation G-protein coupled receptor 5). GN EDG5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Fetal brain; RX MEDLINE=20085044; PubMed=10617617; RA An S., Zheng Y., Bleu T.; RT "Sphingosine 1-phosphate-induced cell proliferation, survival, and RT related signaling events mediated by G protein-coupled receptors Edg3 RT and Edg5."; RL J. Biol. Chem. 275:288-296(2000). RN [2] RP SEQUENCE FROM N.A. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for the lysosphingolipid sphingosine 1- CC phosphate (S1P). S1P is a bioactive lysophospholipid that elicits CC diverse physiological effect on most types of cells and tissues. CC When expressed in rat HTC4 hepatoma cells, is capable of mediating CC S1P-induced cell proliferation and suppression of apoptosis. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF034780; AAC98919.1; -. DR EMBL; AY262688; AAP20652.1; -. DR Genew; HGNC:3169; EDG5. DR MIM; 605111; -. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0008289; F:lipid binding; TAS. DR GO; GO:0000187; P:activation of MAPK; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS. DR InterPro; IPR004063; EDG5_receptor. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR004061; S1P_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01525; EDG5RECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01523; S1PRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family; Lipoprotein; Palmitate. FT DOMAIN 1 34 Extracellular (Potential). FT TRANSMEM 35 59 1 (Potential). FT DOMAIN 60 66 Cytoplasmic (Potential). FT TRANSMEM 67 95 2 (Potential). FT DOMAIN 96 109 Extracellular (Potential). FT TRANSMEM 110 128 3 (Potential). FT DOMAIN 129 147 Cytoplasmic (Potential). FT TRANSMEM 148 173 4 (Potential). FT DOMAIN 174 189 Extracellular (Potential). FT TRANSMEM 190 210 5 (Potential). FT DOMAIN 211 233 Cytoplasmic (Potential). FT TRANSMEM 234 255 6 (Potential). FT DOMAIN 256 271 Extracellular (Potential). FT TRANSMEM 272 292 7 (Potential). FT DOMAIN 293 353 Cytoplasmic (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT LIPID 305 305 S-palmitoyl cysteine (By similarity). FT CONFLICT 113 113 F -> S (in Ref. 1). FT CONFLICT 318 318 G -> V (in Ref. 1). SQ SEQUENCE 353 AA; 38867 MW; 8E37084284ABF7E8 CRC64; MGSLYSEYLN PNKVQEHYNY TKETLETQET TSRQVASAFI VILCCAIVVE NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGSVTLRL TPVQWFAREG SAFITLSASV FSLLAIAIER HVAIAKVKLY GSDKSCRMLL LIGASWLISL VLGGLPILGW NCLGHLEACS TVLPLYAKHY VLCVVTIFSI ILLAIVALYV RIYCVVRSSH ADMAAPQTLA LLKTVTIVLG VFIVCWLPAF SILLLDYACP VHSCPILYKA HYFFAVSTLN SLLNPVIYTW RSRDLRREVL RPLQCWRPGV GVQGRRRGGT PGHHLLPLRS SSSLERGMHM PTSPTFLEGN TVV // ID P2YC_MOUSE STANDARD; PRT; 347 AA. AC Q9CPV9; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE P2Y purinoceptor 12 (P2Y12). GN P2RY12. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Testis; RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for ADP and ATP coupled to G-proteins that CC inhibit the adenylyl cyclase second messenger system (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AK013804; BAB29000.1; -. DR EMBL; AK014807; BAB29561.1; -. DR EMBL; BC025428; AAH25428.1; -. DR EMBL; BC027381; AAH27381.1; -. DR MGD; MGI:1918089; P2ry12. DR GO; GO:0005887; C:integral to plasma membrane; IC. DR GO; GO:0001609; F:adenosine receptor activity, G-protein coupled; IMP. DR GO; GO:0001621; F:platelet ADP receptor activity; IMP. DR GO; GO:0007188; P:G-protein signaling, coupled to cAMP nucleo...; IMP. DR GO; GO:0030168; P:platelet activation; IMP. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005394; P2Y12_purnocptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01569; P2Y12PRNCPTR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 31 Extracellular (Potential). FT TRANSMEM 32 52 1 (Potential). FT DOMAIN 53 64 Cytoplasmic (Potential). FT TRANSMEM 65 85 2 (Potential). FT DOMAIN 86 105 Extracellular (Potential). FT TRANSMEM 106 126 3 (Potential). FT DOMAIN 127 148 Cytoplasmic (Potential). FT TRANSMEM 149 169 4 (Potential). FT DOMAIN 170 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT DOMAIN 219 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 6 (Potential). FT DOMAIN 261 287 Extracellular (Potential). FT TRANSMEM 288 308 7 (Potential). FT DOMAIN 309 347 Cytoplasmic (Potential). FT DISULFID 103 181 By similarity. FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CONFLICT 3 3 V -> M (in Ref. 2; AAH25428). SQ SEQUENCE 347 AA; 39473 MW; F107488E57E025F1 CRC64; MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM // ID GPR4_PIG STANDARD; PRT; 362 AA. AC P50132; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE Probable G protein-coupled receptor GPR4 (GPR19). GN GPR4 OR GPR19. OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=96129306; PubMed=8595909; RA Mahadevan M.S., Baird S., Bailly J.E., Shutler G.G., Sabourin L.A., RA Tsilfidis C., Neville C.E., Narang M., Korneluk R.G.; RT "Isolation of a novel G protein-coupled receptor (GPR4) localized to RT chromosome 19q13.3."; RL Genomics 30:84-88(1995). CC -!- FUNCTION: ORPHAN RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U22108; AAA98458.1; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 17 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 18 42 1 (POTENTIAL). FT DOMAIN 43 54 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 55 76 2 (POTENTIAL). FT DOMAIN 77 91 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 92 113 3 (POTENTIAL). FT DOMAIN 114 132 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 133 154 4 (POTENTIAL). FT DOMAIN 155 179 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 180 201 5 (POTENTIAL). FT DOMAIN 202 224 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 225 245 6 (POTENTIAL). FT DOMAIN 246 263 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 264 284 7 (POTENTIAL). FT DOMAIN 285 362 CYTOPLASMIC (POTENTIAL). FT DISULFID 90 168 BY SIMILARITY. FT CARBOHYD 3 3 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 164 164 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 362 AA; 41163 MW; 6AE748135063858A CRC64; MGNGTWEGCH VDSRVDHLFP PSLYIFVIGV GLPTNCLRLW AAYRQVRQRN ELGVYLMNLS IADLLYICTL PLWVDYFLHH DNWIHGPGSC KLFGFIFYTN IYISIAFLCC ISVDRYLAVA HPLRFARLRR VKTAVAVSSV VWATELGANS VPLFHDELFR DRYNHTFCFE KFPMEGWVAW MNLYRVFVGF LFPWALMLLS YRGILRAVRG SVSTERQEKA KIKRLALSLI AIVLVCFAPY HVLLLSRSAV YLGHPWDCGF EERVFSAYHS SLAFTSLNCV ADPILYCLVN EGARSDVAKA LHNLLRFLTS DKPQEMASAS LTLDTPLTSK RNSMARAVAA AGWHLRPPRD QVQLKMLPPP AP // ID P2YX_HUMAN STANDARD; PRT; 338 AA. AC Q15391; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE UDP-glucose receptor (G protein-coupled receptor GPR105). GN GPR105 OR KIAA0001. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Bone marrow; RX MEDLINE=96051387; PubMed=7584026; RA Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., RA Sato S., Nagase T., Seki N., Ishikawa K.-I., Tabata S.; RT "Prediction of the coding sequences of unidentified human genes. I. RT The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by RT analysis of randomly sampled cDNA clones from human immature myeloid RT cell line KG-1."; RL DNA Res. 1:27-35(1994). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21426338; PubMed=11524702; RA Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S., RA Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E., RA de la Chapelle A., Sankila E.-M.; RT "Mutations in a novel gene with transmembrane domains underlie Usher RT syndrome type 3."; RL Am. J. Hum. Genet. 69:673-684(2001). RN [3] RP FUNCTION. RX MEDLINE=20219108; PubMed=10753868; RA Chambers J.K., Macdonald L.E., Sarau H.M., Ames R.S., Freeman K., RA Foley J.J., Zhu Y., McLaughlin M.M., Murdock P., McMillan L., RA Trill J., Swift A., Aiyar N., Taylor P., Vawter L., Naheed S., RA Szekeres P., Hervieu G., Scott C., Watson J.M., Murphy A.J., Duzic E., RA Klein C., Bergsma D.J., Wilson S., Livi G.P.; RT "A G protein-coupled receptor for UDP-glucose."; RL J. Biol. Chem. 275:10767-10771(2000). CC -!- FUNCTION: Receptor for UDP-glucose and other UDP-sugar coupled to CC G-proteins. Not activated by ATP, ADP, UTP or ATP. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Highest expression in the placenta, adipose CC tissue, stomach and intestine, intermediate levels in the brain, CC spleen, lung and heart, lowest levels in the kidney. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D13626; BAA02791.2; ALT_INIT. DR EMBL; AF456925; AAL47764.1; -. DR Genew; HGNC:16442; GPR105. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0045029; F:UDP-activated nucleotide receptor activity; NAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005466; UDPG_receptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01655; UDPGLUCOSER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 29 Extracellular (Potential). FT TRANSMEM 30 50 1 (Potential). FT DOMAIN 51 55 Cytoplasmic (Potential). FT TRANSMEM 56 76 2 (Potential). FT DOMAIN 77 96 Extracellular (Potential). FT TRANSMEM 97 117 3 (Potential). FT DOMAIN 118 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT DOMAIN 161 188 Extracellular (Potential). FT TRANSMEM 189 209 5 (Potential). FT DOMAIN 210 234 Cytoplasmic (Potential). FT TRANSMEM 235 255 6 (Potential). FT DOMAIN 256 278 Extracellular (Potential). FT TRANSMEM 279 299 7 (Potential). FT DOMAIN 300 338 Cytoplasmic (Potential). FT DISULFID 94 172 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 161 161 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 338 AA; 38971 MW; 8DBE7C782CB4753D CRC64; MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV PSSKSFIIYL KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL FYVNMYVSIV FFGLISFDRY YKIVKPLWTS FIQSVSYSKL LSVIVWMLML LLAVPNIILT NQSVREVTQI KCIELKSELG RKWHKASNYI FVAIFWIVFL LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF VFFVCFVPYH IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTL // ID CLT1_RAT STANDARD; PRT; 339 AA. AC Q924T8; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Cysteinyl leukotriene receptor 1 (CysLTR1). GN CYSLTR1 OR CYSLT1. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RA Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., RA Ohishi T., Soga T., Matsushime H., Furuichi K.; RT "Characterization of cloned rat and porcine cysteinyl leukotriene RT receptors."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for cysteinyl leukotrienes mediating CC constriction of the microvascular smooth muscle during an CC inflammatory response. This response is mediated via a G-protein CC that activates a phosphatidylinositol-calcium second messenger CC system (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB052685; BAB60825.1; -. DR InterPro; IPR004071; Cysleuk_receptor. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01533; CYSLTRECPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 30 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 31 51 1 (POTENTIAL). FT DOMAIN 52 59 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 60 80 2 (POTENTIAL). FT DOMAIN 81 108 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 109 129 3 (POTENTIAL). FT DOMAIN 130 143 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 144 164 4 (POTENTIAL). FT DOMAIN 165 195 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 196 216 5 (POTENTIAL). FT DOMAIN 217 232 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 233 253 6 (POTENTIAL). FT DOMAIN 254 278 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 279 299 7 (POTENTIAL). FT DOMAIN 300 339 CYTOPLASMIC (POTENTIAL). FT DISULFID 98 175 BY SIMILARITY. FT CARBOHYD 6 6 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 171 171 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 339 AA; 39143 MW; 281B41DF050DF8EA CRC64; MVGAENMTAS FSNNRCHDTI DEFRNQVYST MYSMISVVGF FGNSFVLYVL IKTYHEKSAF QVYMINLAIA DLLCVCTLPL RVVYYVHKGK WFFGDFLCRL TTYALYVNLY CSIFFMTAMS FFRCVAIVFP VQNINLVTQK KARFVCVGIW IFVILTSSPF LLSKSYQDEK NNTKCFEPPQ DKQTKKYVLV LHYVSLIFGF IIPFVTIIVC YTMIILTLLK NTMKKNLPSR RKAIGMIIVV TAAFLVSFMP YHIQRAIHLH FLHSETRSCD SVLRMQKSVV ITLSLAASNC CFDPLLYFFS GGNFRRRLST FRKHSLSSMT YIPKKKASLP EKGEEMCKE // ID GP45_MOUSE STANDARD; PRT; 373 AA. AC Q9EQQ4; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Probable G protein-coupled receptor GPR45 (PSP24-alpha) (PSP24-1). GN GPR45. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20483613; PubMed=11027574; RA Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T.; RT "Brain-specific expression of novel G-protein-coupled receptors, with RT homologies to Xenopus PSP24 and human GPR45."; RL Biochem. Biophys. Res. Commun. 276:952-956(2000). CC -!- FUNCTION: Orphan receptor. May play a role in brain function. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Brain specific. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF139642; AAG42572.1; -. DR MGD; MGI:2135882; Gpr45. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 38 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 39 59 1 (POTENTIAL). FT DOMAIN 60 75 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 76 96 2 (POTENTIAL). FT DOMAIN 97 109 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 110 130 3 (POTENTIAL). FT DOMAIN 131 149 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 150 170 4 (POTENTIAL). FT DOMAIN 171 198 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 199 219 5 (POTENTIAL). FT DOMAIN 220 269 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 270 290 6 (POTENTIAL). FT DOMAIN 291 306 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 307 327 7 (POTENTIAL). FT DOMAIN 328 373 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 17 17 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 373 AA; 42358 MW; 693BE5DE9673FB2D CRC64; MACNSTPMGT YEHLLLNVSN TLDPGDTPLS APLRISLAIM MLLMIVVGFL GNTVVCIIVY QRPAMRSAIN LLLATLAFSD IMLSLCCMPF TAITLITVRW HFGDHFCRLS ATLYWFFVLE GVAILLIISV DRFLIIVQRQ DKLNPRRAKM IIAASWVLSF CISAPSFTGW TFMEVPARAP QCVLGYTEFP AERAYVVTLV VAVFFAPFGV MLCSYLCILN TVRKNAVRVH NQSDSLDLRQ LTGAGLRRLR RQQQQASLDL SFKTKAFTTI LILFVGFSLC WLPHSVYSLL SAFSRRFYYS ASFYTTSTCV LWLSYLKSVF NPIVYCWRIK KFREACIELL PHTFQILPKV PERIQRKIQP STIYVCNENQ SAV // ID MAS_HUMAN STANDARD; PRT; 325 AA. AC P04201; DT 20-MAR-1987 (Rel. 04, Created) DT 20-MAR-1987 (Rel. 04, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE MAS proto-oncogene. GN MAS1 OR MAS. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=86218084; PubMed=3708691; RA Young D., Waitches G., Birchmeier C., Fasano O., Wigler M.; RT "Isolation and characterization of a new cellular oncogene encoding a RT protein with multiple potential transmembrane domains."; RL Cell 45:711-719(1986). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [3] RP POSSIBLE FUNCTION. RX MEDLINE=88334724; PubMed=3419518; RA Jackson T.R., Blair L.A.C., Marshall J., Goedert M., Hanley M.R.; RT "The mas oncogene encodes an angiotensin receptor."; RL Nature 335:437-440(1988). CC -!- FUNCTION: Not known. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- DISEASE: The MAS oncogene has a weak focus-inducing activity in CC transfected NIH 3T3 cells. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -!- CAUTION: Was originally (Ref.1) thought to be a receptor for CC angiotensin II. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M13150; AAA36199.1; -. DR EMBL; BC069142; AAH69142.1; -. DR PIR; A01375; TVHUAS. DR Genew; HGNC:6899; MAS1. DR MIM; 165180; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004945; F:angiotensin type II receptor activity; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0008283; P:cell proliferation; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0009653; P:morphogenesis; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Proto-oncogene. FT DOMAIN 1 36 Extracellular (Potential). FT TRANSMEM 37 61 1 (Potential). FT DOMAIN 62 65 Cytoplasmic (Potential). FT TRANSMEM 66 86 2 (Potential). FT DOMAIN 87 104 Extracellular (Potential). FT TRANSMEM 105 128 3 (Potential). FT DOMAIN 129 149 Cytoplasmic (Potential). FT TRANSMEM 150 172 4 (Potential). FT DOMAIN 173 185 Extracellular (Potential). FT TRANSMEM 186 206 5 (Potential). FT DOMAIN 207 224 Cytoplasmic (Potential). FT TRANSMEM 225 245 6 (Potential). FT DOMAIN 246 263 Extracellular (Potential). FT TRANSMEM 264 284 7 (Potential). FT DOMAIN 285 325 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 325 AA; 37465 MW; 3368E7B174744B83 CRC64; MDGSNVTSFV VEEPTNISTG RNASVGNAHR QIPIVHWVIM SISPVGFVEN GILLWFLCFR MRRNPFTVYI THLSIADISL LFCIFILSID YALDYELSSG HYYTIVTLSV TFLFGYNTGL YLLTAISVER CLSVLYPIWY RCHRPKYQSA LVCALLWALS CLVTTMEYVM CIDREEESHS RNDCRAVIIF IAILSFLVFT PLMLVSSTIL VVKIRKNTWA SHSSKLYIVI MVTIIIFLIF AMPMRLLYLL YYEYWSTFGN LHHISLLFST INSSANPFIY FFVGSSKKKR FKESLKVVLT RAFKDEMQPR RQKDNCNTVT VETVV // ID CLT2_RAT STANDARD; PRT; 309 AA. AC Q924T9; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Cysteinyl leukotriene receptor 2 (CysLTR2) (RSBPT32). GN CYSLTR2 OR CYSLT2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RA Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., RA Ohishi T., Soga T., Matsushime H., Furuichi K.; RT "Characterization of the cloned rat and porcine cysteinyl leukotriene RT receptors."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for cysteinyl leukotrienes. The response is CC mediated via a G-protein that activates a phosphatidylinositol- CC calcium second messenger system (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB052661; BAB60816.1; -. DR InterPro; IPR004071; Cysleuk_receptor. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01533; CYSLTRECPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 26 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 27 47 1 (POTENTIAL). FT DOMAIN 48 56 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 57 77 2 (POTENTIAL). FT DOMAIN 78 98 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 99 119 3 (POTENTIAL). FT DOMAIN 120 137 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 138 158 4 (POTENTIAL). FT DOMAIN 159 187 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 188 208 5 (POTENTIAL). FT DOMAIN 209 229 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 230 250 6 (POTENTIAL). FT DOMAIN 251 271 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 272 292 7 (POTENTIAL). FT DOMAIN 293 309 CYTOPLASMIC (POTENTIAL). FT DISULFID 95 171 BY SIMILARITY. FT CARBOHYD 14 14 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 166 166 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 167 167 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 309 AA; 35507 MW; A122AC8177879D56 CRC64; MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT YKKSTSVNVF MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY SLYVNMYTSI YFLTVLSIVR FLATAHPFQM LHITSVRSAW ILCGIIWVFI MASSGLLLKH GQEKKNNTTL CFELNLQKFK NLVILNYIAL GVGFLLPFFI LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF LLCFLPYHAL RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL RAIFSKDHL // ID GP12_MOUSE STANDARD; PRT; 334 AA. AC P35412; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Probable G protein-coupled receptor GPR12 (GPCR01). GN GPR12 OR GPCR12. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BALB/c; TISSUE=Brain; RX MEDLINE=94085630; PubMed=8262253; RA Saeki Y., Ueno S., Mizuno R., Nishimura T., Fujimura H., Nagai Y., RA Yanagihara T.; RT "Molecular cloning of a novel putative G protein-coupled receptor RT (GPCR21) which is expressed predominantly in mouse central nervous RT system."; RL FEBS Lett. 336:317-322(1993). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed predominantly in the forebrain and a CC lesser extent in the hindbrain. Lower expression in the liver. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D21061; BAA04640.1; -. DR EMBL; BC055746; AAH55746.1; -. DR MGD; MGI:101909; Gpr12. DR GO; GO:0001619; F:lysosphingolipid and lysophosphatidic acid ...; IDA. DR GO; GO:0006874; P:calcium ion homeostasis; IDA. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Lipoprotein; KW Palmitate; Phosphorylation. FT DOMAIN 1 46 Extracellular (Potential). FT TRANSMEM 47 66 1 (Potential). FT DOMAIN 67 78 Cytoplasmic (Potential). FT TRANSMEM 79 102 2 (Potential). FT DOMAIN 103 114 Extracellular (Potential). FT TRANSMEM 115 136 3 (Potential). FT DOMAIN 137 157 Cytoplasmic (Potential). FT TRANSMEM 158 177 4 (Potential). FT DOMAIN 178 202 Extracellular (Potential). FT TRANSMEM 203 221 5 (Potential). FT DOMAIN 222 249 Cytoplasmic (Potential). FT TRANSMEM 250 276 6 (Potential). FT DOMAIN 277 281 Extracellular (Potential). FT TRANSMEM 282 303 7 (Potential). FT DOMAIN 304 334 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT DISULFID 188 263 By similarity. FT LIPID 317 317 S-palmitoyl cysteine (By similarity). FT MOD_RES 330 330 Phosphoserine (Potential). FT MOD_RES 332 332 Phosphoserine (Potential). SQ SEQUENCE 334 AA; 36589 MW; 3BE0EE4371F55F5B CRC64; MNEDPKVNLS GLPRDCIDAG APENISAAVP SQGSVAESEP ELVVNPWDIV LCSSGTLICC ENAVVVLIIF HSPSLRAPMF LLIGSLALAD LLAGLGLIIN FVFAYLLQSE ATKLVTIGLI VASFSASVCS LLAITVDRYL SLYYALTYHS ERTVTFTYVM LVMLWGTSIC LGLLPVMGWN CLRDESTCSV VRPLTKNNAA ILSISFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT SHYVTTRKGV STLALILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI YAFRNQEIQK ALCLICCGCI PSSLSQRARS PSDV // ID LGR5_MOUSE STANDARD; PRT; 907 AA. AC Q9Z1P4; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Leucine-rich repeat-containing G protein-coupled receptor 5 precursor DE (G protein-coupled receptor 49) (Orphan G protein-coupled receptor DE FEX). GN GPR49 OR LGR5 OR FEX. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=99121227; PubMed=9920770; RA Hermey G., Methner A., Schaller H.C., Hermans-Borgmeyer I.; RT "Identification of a novel seven-transmembrane receptor with homology RT to glycoprotein receptors and its expression in the adult and RT developing mouse."; RL Biochem. Biophys. Res. Commun. 254:273-279(1999). CC -!- FUNCTION: Orphan receptor. It may be an important receptor for CC signals controlling growth and differenciation of specific CC embryonic tissues. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in the gonads, the adrenal gland, CC and in the brain. In the central nervous system expression is CC restricted to the olfactory bulb. In the adrenal gland detected CC only in the neural-crest derived chromomaffin cells of the CC medulla, but not in the cells of the adrenal cortex. In the CC gonads, the expression is high in Graafian follicle, but absent CC from primary and secondary follicles. CC -!- DEVELOPMENTAL STAGE: Expressed from embryonic day 10.5 (E10.58) in CC the developping spinal cord and in the neuroepipithelia of the CC myel-, met-, mes-, and diencephalon. Expression is transitory and CC the pattern changed rapidly. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -!- SIMILARITY: Contains 17 leucine-rich (LRR) repeats. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF110818; AAD14684.1; -. DR HSSP; P23945; 1XUN. DR MGD; MGI:1341817; Gpr49. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001611; LRR. DR InterPro; IPR000372; LRR_Nterm. DR InterPro; IPR003591; LRR_typ. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF00560; LRR; 15. DR Pfam; PF01462; LRRNT; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00019; LEURICHRPT. DR SMART; SM00369; LRR_TYP; 8. DR SMART; SM00013; LRRNT; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Signal; Transmembrane; Glycoprotein; KW Repeat; Leucine-rich repeat. FT SIGNAL 1 21 POTENTIAL. FT CHAIN 22 907 LEUCINE-RICH REPEAT-CONTAINING G PROTEIN- FT COUPLED RECEPTOR 5. FT DOMAIN 22 561 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 562 582 1 (POTENTIAL). FT DOMAIN 583 593 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 594 614 2 (POTENTIAL). FT DOMAIN 615 638 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 639 659 3 (POTENTIAL). FT DOMAIN 660 682 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 683 703 4 (POTENTIAL). FT DOMAIN 704 723 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 724 744 5 (POTENTIAL). FT DOMAIN 745 767 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 768 788 6 (POTENTIAL). FT DOMAIN 789 802 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 803 823 7 (POTENTIAL). FT DOMAIN 824 907 CYTOPLASMIC (POTENTIAL). FT REPEAT 64 88 LRR 1. FT REPEAT 89 112 LRR 2. FT REPEAT 113 136 LRR 3. FT REPEAT 137 160 LRR 4. FT REPEAT 162 184 LRR 5. FT REPEAT 186 208 LRR 6. FT REPEAT 209 232 LRR 7. FT REPEAT 233 256 LRR 8. FT REPEAT 257 279 LRR 9. FT REPEAT 281 303 LRR 10. FT REPEAT 304 327 LRR 11. FT REPEAT 328 350 LRR 12. FT REPEAT 351 375 LRR 13. FT REPEAT 377 396 LRR 14. FT REPEAT 397 420 LRR 15. FT REPEAT 422 444 LRR 16. FT REPEAT 564 585 LRR 17. FT CARBOHYD 63 63 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 77 77 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 208 208 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 792 792 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 907 AA; 99681 MW; 553167C6C0AAE253 CRC64; MDTSCVHMLL SLLALLQLVA AGSSPGPDAI PRGCPSHCHC ELDGRMLLRV DCSDLGLSEL PSNLSVFTSY LDLSMNNISQ LPASLLHRLC FLEELRLAGN ALTHIPKGAF TGLHSLKVLM LQNNQLRKVP EEALQNLRSL QSLRLDANHI SYVPPSCFSG LHSLRHLWLD DNALTDVPVQ AFRSLSALQA MTLALNKIHH IADYAFGNLS SLVVLHLHNN RIHSLGKKCF DGLHSLETLD LNYNNLDEFP TAIKTLSNLK ELGFHSNNIR SIPERAFVGN PSLITIHFYD NPIQFVGVSA FQHLPELRTL TLNGASHITE FPHLTGTATL ESLTLTGAKI SSLPQAVCDQ LPNLQVLDLS YNLLEDLPSL SGCQKLQKID LRHNEIYEIK GSTFQQLFNL RSLNLAWNKI AIIHPNAFST LPSLIKLDLS SNLLSSFPVT GLHGLTHLKL TGNRALQSLI PSANFPELKI IEMPSAYQCC AFGGCENVYK ISNQWNKDDG NSVDDLHKKD AGLFQVQDER DLEDFLLDFE EDLNALHSVQ CSPSPGPFKP CEHLFGSWLI RIGVWTTAVL TLSCNALVAL TVFRTPLYIS SIKLLIGVIA VVDILMGVSS AVLAAVDAFT FGRFAQHGAW WEDGIGCQIV GFLSIFASES SIFLLTLAAL ERGFSVKCSS KFEVKAPLFS LRAIVLLCVL LALTIATIPL LGGSKYNASP LCLPLPFGEP STTGYMVALV LLNSLCFLIM TIAYTKLYCS LEKGELENLW DCSMVKHIAL LLFANCILYC PVAFLSFSSL LNLTFISPDV IKFILLVIVP LPSCLNPLLY IVFNPHFKED MGSLGKHTRF WMRSKHASLL SINSDDVEKR SCESTQALVS FTHASIAYDL PSTSGASPAY PMTESCHLSS VAFVPCL // ID GP31_HUMAN STANDARD; PRT; 319 AA. AC O00270; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Probable G protein-coupled receptor GPR31. GN GPR31. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RX MEDLINE=97349123; PubMed=9205127; RA Zingoni A., Rocchi M., Storlazzi C.T., Bernardini G., Santoni A., RA Napolitano M.; RT "Isolation and chromosomal localization of GPR31, a human gene RT encoding a putative G protein-coupled receptor."; RL Genomics 42:519-523(1997). CC -!- FUNCTION: ORPHAN RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U65402; AAC51375.1; -. DR Genew; HGNC:4486; GPR31. DR MIM; 602043; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane. FT DOMAIN 1 16 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 17 37 1 (POTENTIAL). FT DOMAIN 38 52 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 53 73 2 (POTENTIAL). FT DOMAIN 74 91 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 92 110 3 (POTENTIAL). FT DOMAIN 111 131 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 132 152 4 (POTENTIAL). FT DOMAIN 153 180 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 181 201 5 (POTENTIAL). FT DOMAIN 202 219 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 220 240 6 (POTENTIAL). FT DOMAIN 241 265 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 266 284 7 (POTENTIAL). FT DOMAIN 285 319 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 319 AA; 35079 MW; 7A4F164CD9C969DD CRC64; MPFPNCSAPS TVVATAVGVL LGLECGLGLL GNAVALWTFL FRVRVWKPYA VYLLNLALAD LLLAACLPFL AAFYLSLQAW HLGRVGCWAL RFLLDLSRSV GMAFLAAVAL DRYLRVVHPR LKVNLLSPQA ALGVSGLVWL LMVALTCPGL LISEAAQNST RCHSFYSRAD GSFSIIWQEA LSCLQFVLPF GLIVFCNAGI IRALQKRLRE PEKQPKLQRA QALVTLVVVL FALCFLPCFL ARVLMHIFQN LGSCRALCAV AHTSDVTGSL TYLHSVVNPV VYCFSSPTFR SSYRRVFHTL RGKGQAAEPP DFNPRDSYS // ID GP85_RAT STANDARD; PRT; 370 AA. AC P60895; Q9JHI6; Q9NPD1; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Probable G protein-coupled receptor GPR85 (Super conserved receptor DE expressed in brain 2) (PKrCx1). GN GPR85 OR SREB2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=20294882; PubMed=10833454; RA Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., RA Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.; RT "An evolutionarily conserved G-protein coupled receptor family, SREB, RT expressed in the central nervous system."; RL Biochem. Biophys. Res. Commun. 272:576-582(2000). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; RA Kim H., Park S., Kang Y., Kim C., Jeon J.; RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity). CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AB040803; BAA96649.1; -. DR EMBL; AF203907; AAG42284.1; -. DR RGD; 71011; Gpr85. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Multigene family. FT DOMAIN 1 25 Extracellular (Potential). FT TRANSMEM 26 46 1 (Potential). FT DOMAIN 47 57 Cytoplasmic (Potential). FT TRANSMEM 58 78 2 (Potential). FT DOMAIN 79 96 Extracellular (Potential). FT TRANSMEM 97 117 3 (Potential). FT DOMAIN 118 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 4 (Potential). FT DOMAIN 159 188 Extracellular (Potential). FT TRANSMEM 189 209 5 (Potential). FT DOMAIN 210 286 Cytoplasmic (Potential). FT TRANSMEM 287 307 6 (Potential). FT DOMAIN 308 313 Extracellular (Potential). FT TRANSMEM 314 334 7 (Potential). FT DOMAIN 335 370 Cytoplasmic (Potential). FT DISULFID 94 172 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 83 83 N-linked (GlcNAc...) (Potential). FT CARBOHYD 182 182 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 370 AA; 41994 MW; 7B67A39F6166AAEB CRC64; MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF STTLLYCRKS RLPREPYCVI // ID GP43_HUMAN STANDARD; PRT; 330 AA. AC O15552; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Probable G protein-coupled receptor GPR43. GN GPR43. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98008875; PubMed=9344866; RA Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., RA O'Dowd B.F.; RT "A cluster of four novel human G protein-coupled receptor genes RT occurring in close proximity to CD22 gene on chromosome 19q13.1."; RL Biochem. Biophys. Res. Commun. 239:543-547(1997). RN [2] RP SEQUENCE FROM N.A. RA Lamerdin J.E., McCready P.M., Adamson A.W., Burkhart-Schultz K., RA Garcia E., Kyle A., Ramirez M., Stilwagen S., Garnes J., Danganan L., RA Bruce R., Quan G., Montgomery M., Ow D., Kobayashi A., Olsen A.O., RA Carrano A.V.; RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: ORPHAN RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; AF024690; AAB86713.1; -. DR EMBL; AC002511; AAB67886.1; -. DR Genew; HGNC:4501; GPR43. DR MIM; 603823; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Polymorphism. FT DOMAIN 1 12 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 13 33 1 (POTENTIAL). FT DOMAIN 34 41 CYTOPLASMIC. FT TRANSMEM 42 62 2 (POTENTIAL). FT DOMAIN 63 84 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 85 105 3 (POTENTIAL). FT DOMAIN 106 126 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 127 147 4 (POTENTIAL). FT DOMAIN 148 173 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 174 194 5 (POTENTIAL). FT DOMAIN 195 219 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 220 240 6 (POTENTIAL). FT DOMAIN 241 255 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 256 276 7 (POTENTIAL). FT DOMAIN 277 330 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 151 151 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 167 167 N-LINKED (GLCNAC...) (POTENTIAL). FT VARIANT 211 211 L -> H (IN DBSNP:409093). FT /FTId=VAR_011861. SQ SEQUENCE 330 AA; 37143 MW; F4A8AC6AFBDF1E90 CRC64; MLPDWKSSLI LMAYIIIFLT GLPANLLALR AFVGRIRQPQ PAPVHILLLS LTLADLLLLL LLPFKIIEAA SNFRWYLPKV VCALTSFGFY SSIYCSTWLL AGISIERYLG VAFPVQYKLS RRPLYGVIAA LVAWVMSFGH CTIVIIVQYL NTTEQVRSGN EITCYENFTD NQLDVVLPVR LELCLVLFFI PMAVTIFCYW RFVWIMLSQP LVGAQRRRRA VGLAVVTLLN FLVCFGPYNV SHLVGYHQRK SPWWRSIAVV FSSLNASLDP LLFYFSSSVV RRAFGRGLQV LRNQGSSLLG RRGKDTAEGT NEDRGVGQGE GMPSSDFTTE // ID GP21_HUMAN STANDARD; PRT; 349 AA. AC Q99679; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Probable G protein-coupled receptor GPR21. GN GPR21. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97225799; PubMed=9073069; RA O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., RA Heng H.H.Q., Kolakowski L.F. Jr., Lynch K.R., George S.R.; RT "Cloning and chromosomal mapping of four putative novel human RT G-protein-coupled receptor genes."; RL Gene 187:75-81(1997). CC -!- FUNCTION: ORPHAN RECEPTOR. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: NOT DETECTED IN THE BRAIN REGIONS THALAMUS, CC PUTAMEN, CAUDATE, FRONTAL CORTEX, PONS, HYPOTHALAMUS, HIPPOCAMPUS. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U66580; AAC51303.1; -. DR Genew; HGNC:4476; GPR21. DR MIM; 601909; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein. FT DOMAIN 1 32 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 33 53 1 (POTENTIAL). FT DOMAIN 54 75 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 76 96 2 (POTENTIAL). FT DOMAIN 97 104 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 105 125 3 (POTENTIAL). FT DOMAIN 126 147 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 148 168 4 (POTENTIAL). FT DOMAIN 169 191 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 192 212 5 (POTENTIAL). FT DOMAIN 213 252 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 253 273 6 (POTENTIAL). FT DOMAIN 274 283 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 284 304 7 (POTENTIAL). FT DOMAIN 305 349 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 2 2 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 8 8 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 349 AA; 39515 MW; 5369DFC216E9EEC4 CRC64; MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI FVFHCAPLLN HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL TCQIFGFVVS VLKSVSMASL ACISIDRYIA ITKPLTYNTL VTPWRLRLCI FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW CAESWHTDSY FTLFIVMMLY APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG EVQACPDKRY AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI //