ID MC4R_HUMAN STANDARD; PRT; 332 AA. AC P32245; Q16317; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 25-OCT-2004, sequence version 2. DT 18-APR-2006, entry version 63. DE Melanocortin receptor 4 (MC4-R). GN Name=MC4R; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE, AND VARIANT ILE-103. RX MEDLINE=93315499; PubMed=8392067; RA Gantz I., Miwa H., Konda Y., Shimoto Y., Tashiro T., Waston S.J., RA Delvalle J.; RT "Molecular cloning, expression, and gene localization of a fourth RT melanocortin receptor."; RL J. Biol. Chem. 268:15174-15179(1993). RN [2] RP NUCLEOTIDE SEQUENCE, AND VARIANT ILE-103. RX MEDLINE=95157557; PubMed=7854347; DOI=10.1210/me.8.10.1298; RA Mountjoy K.G., Mortrud M.T., Low M.J., Simerly R.B., Cone R.D.; RT "Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine RT and autonomic control circuits in the brain."; RL Mol. Endocrinol. 8:1298-1308(1994). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP VARIANTS OBESITY ARG-30; VAL-37; LEU-78; MET-112; TRP-165; SER-252 AND RP THR-317, AND VARIANT LEU-251. RX MEDLINE=99213892; PubMed=10199800; DOI=10.1210/jc.84.4.1483; RA Hinney A., Schmidt A., Nottebom K., Heibult O., Becker I., Ziegler A., RA Gerber G., Sina M., Gorg T., Mayer H., Siegfried W., Fichter M., RA Remschmidt H., Hebebrand J.; RT "Several mutations in the melanocortin-4 receptor gene including a RT nonsense and a frameshift mutation associated with dominantly RT inherited obesity in humans."; RL J. Clin. Endocrinol. Metab. 84:1483-1486(1999). RN [6] RP VARIANT OBESITY SER-274. RX MEDLINE=21336749; PubMed=11443223; DOI=10.1210/jc.86.7.3448; RA Mergen M., Mergen H., Ozata M., Oner R., Oner C.; RT "A novel melanocortin 4 receptor (MC4R) gene mutation associated with RT morbid obesity."; RL J. Clin. Endocrinol. Metab. 86:3448-3448(2001). CC -!- FUNCTION: Receptor specific to the heptapeptide core common to CC adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This CC receptor is mediated by G proteins that stimulate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain, placental, and gut tissues. CC -!- DISEASE: Defects in MC4R are a cause of autosomal dominant obesity CC [MIM:601665]. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L08603; AAA35791.1; -; Genomic_DNA. DR EMBL; S77415; AAB33341.1; -; Genomic_DNA. DR EMBL; AY236539; AAO92061.1; -; Genomic_DNA. DR EMBL; BC069172; AAH69172.1; -; mRNA. DR PIR; A57055; A57055. DR UniGene; Hs.532833; -. DR Ensembl; ENSG00000166603; Homo sapiens. DR HGNC; HGNC:6932; MC4R. DR MIM; 155541; gene. DR MIM; 601665; phenotype. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004977; F:melanocortin receptor activity; TAS. DR GO; GO:0007631; P:feeding behavior; TAS. DR GO; GO:0007188; P:G-protein signaling, coupled to cAMP nucleo...; TAS. DR GO; GO:0007582; P:physiological process; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000155; Mcort_rcpt_4. DR InterPro; IPR001908; Melancort_rcpt. DR InterPro; IPR001671; Melcrt_ACTH_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00535; MELNOCORTINR. DR PRINTS; PR01062; MELNOCORTN4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Disease mutation; G-protein coupled receptor; Glycoprotein; KW Lipoprotein; Membrane; Obesity; Palmitate; Phosphorylation; KW Polymorphism; Receptor; Transducer; Transmembrane. FT CHAIN 1 332 Melanocortin receptor 4. FT /FTId=PRO_0000069722. FT TOPO_DOM 1 43 Extracellular (Potential). FT TRANSMEM 44 69 1 (Potential). FT TOPO_DOM 70 81 Cytoplasmic (Potential). FT TRANSMEM 82 106 2 (Potential). FT TOPO_DOM 107 123 Extracellular (Potential). FT TRANSMEM 124 145 3 (Potential). FT TOPO_DOM 146 165 Cytoplasmic (Potential). FT TRANSMEM 166 186 4 (Potential). FT TOPO_DOM 187 191 Extracellular (Potential). FT TRANSMEM 192 215 5 (Potential). FT TOPO_DOM 216 248 Cytoplasmic (Potential). FT TRANSMEM 249 271 6 (Potential). FT TOPO_DOM 272 280 Extracellular (Potential). FT TRANSMEM 281 304 7 (Potential). FT TOPO_DOM 305 332 Cytoplasmic (Potential). FT LIPID 318 318 S-palmitoyl cysteine (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT VARIANT 30 30 S -> R (in obesity). FT /FTId=VAR_010704. FT VARIANT 37 37 D -> V (in obesity). FT /FTId=VAR_010705. FT VARIANT 78 78 P -> L (in obesity). FT /FTId=VAR_010706. FT VARIANT 103 103 V -> I. FT /FTId=VAR_010707. FT VARIANT 112 112 T -> M (in obesity). FT /FTId=VAR_010708. FT VARIANT 165 165 R -> W (in obesity). FT /FTId=VAR_010709. FT VARIANT 251 251 I -> L. FT /FTId=VAR_010710. FT VARIANT 252 252 G -> S (in obesity). FT /FTId=VAR_010711. FT VARIANT 274 274 N -> S (in obesity). FT /FTId=VAR_015357. FT VARIANT 317 317 I -> T (in obesity). FT /FTId=VAR_010712. FT CONFLICT 169 169 I -> S (in Ref. 2). SQ SEQUENCE 332 AA; 36943 MW; E80010BAADBED2B4 CRC64; MVNSTHRGMH TSLHLWNRSS YRLHSNASES LGKGYSDGGC YEQLFVSPEV FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT IFYALQYHNI MTVKRVGIII SCIWAACTVS GILFIIYSDS SAVIICLITM FFTMLALMAS LYVHMFLMAR LHIKRIAVLP GTGAIRQGAN MKGAITLTIL IGVFVVCWAP FFLHLIFYIS CPQNPYCVCF MSHFNLYLIL IMCNSIIDPL IYALRSQELR KTFKEIICCY PLGGLCDLSS RY // ID MC3R_MOUSE STANDARD; PRT; 323 AA. AC P33033; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 18-APR-2006, entry version 45. DE Melanocortin receptor 3 (MC3-R). GN Name=Mc3r; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=94226597; PubMed=8172596; RA Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M.; RT "Molecular cloning, functional expression and pharmacological RT characterization of a mouse melanocortin receptor gene."; RL Biochem. J. 299:367-373(1994). CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. This CC receptor is mediated by G proteins which activate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X74983; CAA52918.1; -; Genomic_DNA. DR PIR; S43850; S43850. DR UniGene; Mm.57183; -. DR Ensembl; ENSMUSG00000038537; Mus musculus. DR MGI; MGI:96929; Mc3r. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR002122; Mcort_3_rcpt. DR InterPro; IPR001908; Melancort_rcpt. DR InterPro; IPR001671; Melcrt_ACTH_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00535; MELNOCORTINR. DR PRINTS; PR01061; MELNOCORTN3R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 323 Melanocortin receptor 3. FT /FTId=PRO_0000069719. FT TOPO_DOM 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT TOPO_DOM 64 75 Cytoplasmic (Potential). FT TRANSMEM 76 100 2 (Potential). FT TOPO_DOM 101 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT TOPO_DOM 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT TOPO_DOM 182 186 Extracellular (Potential). FT TRANSMEM 187 210 5 (Potential). FT TOPO_DOM 211 245 Cytoplasmic (Potential). FT TRANSMEM 246 268 6 (Potential). FT TOPO_DOM 269 277 Extracellular (Potential). FT TRANSMEM 278 301 7 (Potential). FT TOPO_DOM 302 323 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 323 AA; 35806 MW; F4B7B02FA4A87B7B CRC64; MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAI DRYVTIFYAL RYHSIMTVRK ALTLIGVIWV CCGICGVMFI IYSESKMVIV CLITMFFAMV LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA FRSLELRNTF KEILCGCNSM NLG // ID MSHR_CHICK STANDARD; PRT; 314 AA. AC P55167; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 04-APR-2006, entry version 38. DE Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin receptor 1) (MC1-R). GN Name=MC1R; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Rock-Cornish breed; RX MEDLINE=96221280; PubMed=8634326; DOI=10.1016/0167-4781(96)00026-7; RA Takeuchi S., Suzuki H., Hirose S., Yabuuchi M., Sato C., Yamamoto H., RA Takahashi S.; RT "Molecular cloning and sequence analysis of the chick melanocortin 1- RT receptor gene."; RL Biochim. Biophys. Acta 1306:122-126(1996). CC -!- FUNCTION: Receptor for MSH (alpha, beta) and ACTH. Does not seem CC to be active with gamma-MSH. The activity of this receptor is CC mediated by G proteins which activate adenylate cyclase (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; D78272; BAA11336.1; -; Genomic_DNA. DR PIR; S70005; S70005. DR UniGene; Gga.32102; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Melcrt_ACTH_rcpt. DR InterPro; IPR000761; MSH_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 314 Melanocyte-stimulating hormone receptor. FT /FTId=PRO_0000069859. FT TOPO_DOM 1 35 Extracellular (Potential). FT TRANSMEM 36 61 1 (Potential). FT TOPO_DOM 62 70 Cytoplasmic (Potential). FT TRANSMEM 71 91 2 (Potential). FT TOPO_DOM 92 116 Extracellular (Potential). FT TRANSMEM 117 138 3 (Potential). FT TOPO_DOM 139 161 Cytoplasmic (Potential). FT TRANSMEM 162 181 4 (Potential). FT TOPO_DOM 182 189 Extracellular (Potential). FT TRANSMEM 190 209 5 (Potential). FT TOPO_DOM 210 237 Cytoplasmic (Potential). FT TRANSMEM 238 263 6 (Potential). FT TOPO_DOM 264 276 Extracellular (Potential). FT TRANSMEM 277 297 7 (Potential). FT TOPO_DOM 298 314 Cytoplasmic (Potential). FT LIPID 312 312 S-palmitoyl cysteine (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 314 AA; 35297 MW; 10C64A57B0C75EB0 CRC64; MSMLAPLRLV REPWNASEGN QSNATAGAGG AWCQGLDIPN ELFLTLGLVS LVENLLVVAA ILKNRNLHSP TYYFICCLAV SDMLVSVSNL AKTLFMLLME HGVLVIRASI VRHMDNVIDM LICSSVVSSL SFLGVIAVDR YITIFYALRY HSIMTLQRAV VTMASVWLAS TVSSTVLITY YRNNAILLCL IGFFLFMLVL MLVLYIHMFA LACHHVRSIS SQQKQPTIYR TSSLKGAVTL TILLGVFFIC WGPFFFHLIL IVTCPTNPFC TCFFSYFNLF LILIICNSVV DPLIYAFRSQ ELRRTLREVV LCSW // ID BRS3_HUMAN STANDARD; PRT; 399 AA. AC P32247; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 18-APR-2006, entry version 57. DE Bombesin receptor subtype-3 (BRS-3). GN Name=BRS3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=93194908; PubMed=8383682; RA Fathi Z., Corjay M.H., Shapira H., Wada E., Benya R., Jensen R., RA Viallet J., Sausville E.A., Battey J.F.; RT "BRS-3: a novel bombesin receptor subtype selectively expressed in RT testis and lung carcinoma cells."; RL J. Biol. Chem. 268:5979-5984(1993). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Uterus; RX MEDLINE=94178377; PubMed=8131855; DOI=10.1016/0014-5793(94)80150-9; RA Gorbulev V., Akhundova A., Grzeschik K.H., Fahrenholz F.; RT "Organization and chromosomal localization of the gene for the human RT bombesin receptor subtype expressed in pregnant uterus."; RL FEBS Lett. 340:260-264(1994). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., RA Williams G., Williams L., Williamson A., Williamson H., Wilming L., RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R., Hubbard T., RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). CC -!- FUNCTION: Role in sperm cell division, maturation, or function. CC This receptor mediates its action by association with G proteins CC that activate a phosphatidylinositol-calcium second messenger CC system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: In germ cells in testis. Lung carcinoma cells. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L08893; AAA35604.1; -; mRNA. DR EMBL; X76498; CAA54031.1; -; Genomic_DNA. DR EMBL; AY585193; AAT79496.1; -; mRNA. DR EMBL; Z97632; CAB10731.1; -; Genomic_DNA. DR PIR; A46632; A46632. DR UniGene; Hs.121484; -. DR Ensembl; ENSG00000102239; Homo sapiens. DR HGNC; HGNC:1113; BRS3. DR MIM; 300107; gene. DR LinkHub; P32247; -. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; NAS. DR GO; GO:0004946; F:bombesin receptor activity; TAS. DR GO; GO:0008343; P:adult feeding behavior; TAS. DR GO; GO:0008217; P:blood pressure regulation; TAS. DR GO; GO:0006006; P:glucose metabolism; TAS. DR InterPro; IPR001560; Bombesin_rcpt_3. DR InterPro; IPR001556; Bombsn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF59; Bmbsn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00637; BOMBESIN3R. DR PRINTS; PR00358; BOMBESINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Polymorphism; Receptor; Transducer; Transmembrane. FT CHAIN 1 399 Bombesin receptor subtype-3. FT /FTId=PRO_0000069196. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 63 1 (Potential). FT TOPO_DOM 64 82 Cytoplasmic (Potential). FT TRANSMEM 83 103 2 (Potential). FT TOPO_DOM 104 121 Extracellular (Potential). FT TRANSMEM 122 143 3 (Potential). FT TOPO_DOM 144 163 Cytoplasmic (Potential). FT TRANSMEM 164 184 4 (Potential). FT TOPO_DOM 185 220 Extracellular (Potential). FT TRANSMEM 221 241 5 (Potential). FT TOPO_DOM 242 272 Cytoplasmic (Potential). FT TRANSMEM 273 293 6 (Potential). FT TOPO_DOM 294 313 Extracellular (Potential). FT TRANSMEM 314 333 7 (Potential). FT TOPO_DOM 334 399 Cytoplasmic (Potential). FT LIPID 347 347 S-palmitoyl cysteine (By similarity). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT DISULFID 120 203 By similarity. FT VARIANT 53 53 T -> P (in dbSNP:5232). FT /FTId=VAR_011844. FT VARIANT 162 162 L -> Q (in dbSNP:5234). FT /FTId=VAR_011845. SQ SEQUENCE 399 AA; 44411 MW; 979C93E962A3A28A CRC64; MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI YITYAVIISV GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC VPVDATHYLA EGWLFGRIGC KVLSFIRLTS VGVSVFTLTI LSADRYKAVV KPLERQPSNA ILKTCVKAGC VWIVSMIFAL PEAIFSNVYT FRDPNKNMTF ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI ARTLYKSTLN IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA ERPEPPVADT SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF // ID GRPR_MOUSE STANDARD; PRT; 384 AA. AC P21729; DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1991, sequence version 2. DT 18-APR-2006, entry version 54. DE Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin DE receptor). GN Name=Grpr; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE. RC STRAIN=Swiss; TISSUE=Fibroblast; RX MEDLINE=91110536; PubMed=1671171; RA Battey J.F., Way J.M., Corjay M.H., Shapira H., Kusano K., Harkins R., RA Wu J.M., Slattery T., Mann E., Feldman R.I.; RT "Molecular cloning of the bombesin/gastrin-releasing peptide receptor RT from Swiss 3T3 cells."; RL Proc. Natl. Acad. Sci. U.S.A. 88:395-399(1991). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Swiss; TISSUE=Fibroblast; RX MEDLINE=91187004; PubMed=1707129; RA Spindel E.R., Giladi E., Brehm P., Goodman R.H., Segerson T.P.; RT "Cloning and functional characterization of a complementary DNA RT encoding the murine fibroblast bombesin/gastrin-releasing peptide RT receptor."; RL Mol. Endocrinol. 4:1956-1963(1990). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=93305484; PubMed=8391296; RA Giladi E., Nagalla S.R., Spindel E.R.; RT "Molecular cloning and characterization of receptors for the mammalian RT bombesin-like peptides."; RL J. Mol. Neurosci. 4:41-54(1993). CC -!- FUNCTION: Receptor for gastrin releasing peptide (GRP). This CC receptor mediates its action by association with G proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain (hypothalamus), pancreatic acinar cells, CC and fibroblasts. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M57922; AAA75650.1; -; mRNA. DR EMBL; M61000; AAA37744.1; -; mRNA. DR PIR; A39003; A39003. DR UniGene; Mm.4687; -. DR Ensembl; ENSMUSG00000031364; Mus musculus. DR MGI; MGI:95836; Grpr. DR GO; GO:0004946; F:bombesin receptor activity; TAS. DR GO; GO:0042127; P:regulation of cell proliferation; IMP. DR InterPro; IPR001556; Bombsn_rcpt. DR InterPro; IPR001966; Gastrin_pep_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF59; Bmbsn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00358; BOMBESINR. DR PRINTS; PR00640; GASTRINRELPR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Direct protein sequencing; G-protein coupled receptor; Glycoprotein; KW Lipoprotein; Membrane; Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 384 Gastrin-releasing peptide receptor. FT /FTId=PRO_0000069663. FT TOPO_DOM 1 39 Extracellular (Potential). FT TRANSMEM 40 63 1 (Potential). FT TOPO_DOM 64 77 Cytoplasmic (Potential). FT TRANSMEM 78 97 2 (Potential). FT TOPO_DOM 98 115 Extracellular (Potential). FT TRANSMEM 116 137 3 (Potential). FT TOPO_DOM 138 153 Cytoplasmic (Potential). FT TRANSMEM 154 175 4 (Potential). FT TOPO_DOM 176 209 Extracellular (Potential). FT TRANSMEM 210 235 5 (Potential). FT TOPO_DOM 236 265 Cytoplasmic (Potential). FT TRANSMEM 266 286 6 (Potential). FT TOPO_DOM 287 299 Extracellular (Potential). FT TRANSMEM 300 326 7 (Potential). FT TOPO_DOM 327 384 Cytoplasmic (Potential). FT LIPID 340 340 S-palmitoyl cysteine (By similarity). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT DISULFID 114 197 By similarity. FT CONFLICT 309 309 R -> H (in Ref. 2). SQ SEQUENCE 384 AA; 43215 MW; BF6D60387AA09A2C CRC64; MAPNNCSHLN LDVDPFLSCN DTFNQSLSPP KMDNWFHPGF IYVIPAVYGL IIVIGLIGNI TLIKIFCTVK SMRNVPNLFI SSLALGDLLL LVTCAPVDAS KYLADRWLFG RIGCKLIPFI QLTSVGVSVF TLTALSADRY KAIVRPMDIQ ASHALMKICL KAALIWIVSM LLAIPEAVFS DLHPFHVKDT NQTFISCAPY PHSNELHPKI HSMASFLVFY VIPLAIISVY YYFIARNLIQ SAYNLPVEGN IHVKKQIESR KRLAKTVLVF VGLFAFCWLP NHVIYLYRSY HYSEVDTSML HFVTSICARL LAFTNSCVNP FALYLLSKSF RKQFNTQLLC CQPGLMNRSH STGRSTTCMT SFKSTNPSAT FSLINRNICH EGYV // ID EDNRA_BOVIN STANDARD; PRT; 427 AA. AC P21450; DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1991, sequence version 2. DT 04-APR-2006, entry version 43. DE Endothelin-1 receptor precursor (Endothelin A receptor) (ET-A). GN Name=EDNRA; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung; RX MEDLINE=91080923; PubMed=2175396; DOI=10.1038/348730a0; RA Arai H., Hori S., Aramori I., Ohkubo H., Nakanishi S.; RT "Cloning and expression of a cDNA encoding an endothelin receptor."; RL Nature 348:730-732(1990). CC -!- FUNCTION: Receptor for endothelin-1. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. The rank order of binding CC affinities for ET-A is: ET1 > ET2 >> ET3. CC -!- SUBUNIT: Interacts with HDAC7 and HTATIP (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X57765; CAA40917.1; -; mRNA. DR PIR; S13424; S13424. DR UniGene; Bt.4719; -. DR InterPro; IPR000499; Endthln_rcpt. DR InterPro; IPR002175; ETA_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00570; ENDOTHELINAR. DR PRINTS; PR00366; ENDOTHELINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Signal; KW Transducer; Transmembrane. FT SIGNAL 1 20 Potential. FT CHAIN 21 427 Endothelin-1 receptor. FT /FTId=PRO_0000012719. FT TOPO_DOM 21 80 Extracellular (Potential). FT TRANSMEM 81 102 1 (Potential). FT TOPO_DOM 103 112 Cytoplasmic (Potential). FT TRANSMEM 113 132 2 (Potential). FT TOPO_DOM 133 159 Extracellular (Potential). FT TRANSMEM 160 181 3 (Potential). FT TOPO_DOM 182 205 Cytoplasmic (Potential). FT TRANSMEM 206 229 4 (Potential). FT TOPO_DOM 230 256 Extracellular (Potential). FT TRANSMEM 257 278 5 (Potential). FT TOPO_DOM 279 306 Cytoplasmic (Potential). FT TRANSMEM 307 328 6 (Potential). FT TOPO_DOM 329 347 Extracellular (Potential). FT TRANSMEM 348 372 7 (Potential). FT TOPO_DOM 373 427 Cytoplasmic (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 62 62 N-linked (GlcNAc...) (Potential). FT DISULFID 158 239 By similarity. SQ SEQUENCE 427 AA; 48515 MW; 73CF44404CD9AC14 CRC64; METFWLRLSF WVALVGGVIS DNPESYSTNL SIHVDSVATF HGTELSFVVT THQPTNLALP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFEQ NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGAQHRTCM LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDTNR CELLSFLLLM DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH EQNNHNTERS SHKDSIN // ID EDNR3_XENLA STANDARD; PRT; 444 AA. AC P32940; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 04-APR-2006, entry version 41. DE Endothelin-3 receptor precursor (ET-C). OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Dermal melanophore; RX MEDLINE=93366838; PubMed=8360195; RA Karne S., Jayawickreme C.K., Lerner M.R.; RT "Cloning and characterization of an endothelin-3 specific receptor RT (ETC receptor) from Xenopus laevis dermal melanophores."; RL J. Biol. Chem. 268:19126-19133(1993). CC -!- FUNCTION: Receptor for endothelin-3. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L20299; AAA49704.1; -; mRNA. DR PIR; A48538; A48538. DR UniGene; Xl.764; -. DR InterPro; IPR000499; Endthln_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00366; ENDOTHELINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Signal; KW Transducer; Transmembrane. FT SIGNAL 1 18 Potential. FT CHAIN 19 444 Endothelin-3 receptor. FT /FTId=PRO_0000012734. FT TOPO_DOM 19 88 Extracellular (Potential). FT TRANSMEM 89 113 1 (Potential). FT TOPO_DOM 114 124 Cytoplasmic (Potential). FT TRANSMEM 125 145 2 (Potential). FT TOPO_DOM 146 161 Extracellular (Potential). FT TRANSMEM 162 180 3 (Potential). FT TOPO_DOM 181 201 Cytoplasmic (Potential). FT TRANSMEM 202 226 4 (Potential). FT TOPO_DOM 227 254 Extracellular (Potential). FT TRANSMEM 255 279 5 (Potential). FT TOPO_DOM 280 307 Cytoplasmic (Potential). FT TRANSMEM 308 328 6 (Potential). FT TOPO_DOM 329 365 Extracellular (Potential). FT TRANSMEM 366 386 7 (Potential). FT TOPO_DOM 387 444 Cytoplasmic (Potential). FT CARBOHYD 60 60 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 444 AA; 50172 MW; 80AB7EC36720D783 CRC64; MATVILFVAW MACLMVGVCY QEFQTQQNFP DISNPSQELN QEPAHRIVQL DSIQNNGALN MSTGNVLNMS PPPPSPCLSR AKIRHAFKYV TTILSCVIFL VGIVGNSTLL RIIYKNKCMR NGPNVLIASL ALGDLFYILI AIPIISISFW LSTGHSEYIY QLVHLYRARV YSLSLCALSI DRYRAVASWN RIRSIGIPVR KAIELTLIWA VAIIVAVPEA IAFNLVELDF RGQTILVCML PMEQTSDFMR FYQEVKVWWL FGFYFCLPLA CTGVFYTLMS CEMLSIKNGM RIALNDHMKQ RREVAKTVFC LVVIFALCWL PLHVSSIFVR LSATVKRACI LKNKRSCIMA EIQTGVNYQL LMVMNYTGIN MASLNSCIGP VALYFVSRKF KNCFQSCLCC WCHRPTLTIT PMDEKGSGGK WKANGHDLDL DRSSSRLSNK YSSS // ID GPR37_MOUSE STANDARD; PRT; 600 AA. AC Q9QY42; Q8BKF8; Q8BXP9; Q8C022; Q9Z0G3; DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 02-MAY-2006, entry version 37. DE Probable G-protein coupled receptor 37 precursor. GN Name=Gpr37; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). RC STRAIN=BALB/c; TISSUE=Brain, and Liver; RX MEDLINE=99017968; PubMed=9799598; DOI=10.1006/geno.1998.5433; RA Marazziti D., Gallo A., Golini E., Matteoni R., RA Tocchini-Valentini G.P.; RT "Molecular cloning and chromosomal localization of the mouse Gpr37 RT gene encoding an orphan G-protein-coupled peptide receptor expressed RT in brain and testis."; RL Genomics 53:315-324(1998). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Platzer M., Zhao W., Herman G.E., Rosenthal A.; RT "Genomic structure of the murine G protein-coupled receptor 37 on RT chromosome 6."; RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC STRAIN=C57BL/6J; TISSUE=Eye, Olfactory bulb, and Retina; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Eye; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBUNIT: Forms a complex with PARK2, STUB1 and HSP70. The amount CC of STUB1 in the complex increases during ER stress. STUB1 promotes CC the dissociation of HSP70 from PARK2, thus facilitating PARK2- CC mediated GPR37 ubiquitination. Interacts with PACRG (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9QY42-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9QY42-2; Sequence=VSP_011762; CC Name=3; CC IsoId=Q9QY42-3; Sequence=VSP_011763, VSP_011764; CC -!- PTM: Ubiquitinated by PARK2 in the presence of ubiquitin- CC conjugating enzymes in the endoplasmic reticulum (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AJ223305; CAA11247.1; -; mRNA. DR EMBL; AJ223834; CAA11579.1; -; Genomic_DNA. DR EMBL; AJ223835; CAA11579.1; JOINED; Genomic_DNA. DR EMBL; AF132039; AAF22144.1; -; Genomic_DNA. DR EMBL; AK032525; BAC27911.1; -; mRNA. DR EMBL; AK044508; BAC31956.1; -; mRNA. DR EMBL; AK053287; BAC35333.1; -; mRNA. DR EMBL; BC031918; AAH31918.1; -; mRNA. DR UniGene; Mm.20465; -. DR MGI; MGI:1313297; Gpr37. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003909; GPR37_rcpt. DR PANTHER; PTHR15279; GPR37_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01421; GPR37ORPHANR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; G-protein coupled receptor; Glycoprotein; KW Membrane; Receptor; Signal; Transducer; Transmembrane; KW Ubl conjugation. FT SIGNAL 1 26 Potential. FT CHAIN 27 600 Probable G-protein coupled receptor 37. FT /FTId=PRO_0000012800. FT TOPO_DOM 27 252 Extracellular (Potential). FT TRANSMEM 253 273 1 (Potential). FT TOPO_DOM 274 286 Cytoplasmic (Potential). FT TRANSMEM 287 307 2 (Potential). FT TOPO_DOM 308 322 Extracellular (Potential). FT TRANSMEM 323 343 3 (Potential). FT TOPO_DOM 344 366 Cytoplasmic (Potential). FT TRANSMEM 367 387 4 (Potential). FT TOPO_DOM 388 430 Extracellular (Potential). FT TRANSMEM 431 451 5 (Potential). FT TOPO_DOM 452 480 Cytoplasmic (Potential). FT TRANSMEM 481 501 6 (Potential). FT TOPO_DOM 502 518 Extracellular (Potential). FT TRANSMEM 519 539 7 (Potential). FT TOPO_DOM 540 600 Cytoplasmic (Potential). FT COMPBIAS 538 558 Cys-rich. FT COMPBIAS 550 555 Poly-Cys. FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CARBOHYD 210 210 N-linked (GlcNAc...) (Potential). FT CARBOHYD 227 227 N-linked (GlcNAc...) (Potential). FT DISULFID 321 406 By similarity. FT VARSPLIC 1 251 Missing (in isoform 2). FT /FTId=VSP_011762. FT VARSPLIC 418 440 IYVLALTYDGARLWWYFGCYFCL -> VQVERDCFIKIRTR FT NHWIRLSHL (in isoform 3). FT /FTId=VSP_011763. FT VARSPLIC 441 600 Missing (in isoform 3). FT /FTId=VSP_011764. FT CONFLICT 205 205 R -> M (in Ref. 3; BAC27911). FT CONFLICT 224 224 R -> P (in Ref. 1). FT CONFLICT 228 228 T -> P (in Ref. 1). FT CONFLICT 326 326 Y -> N (in Ref. 3; BAC27911). FT CONFLICT 399 399 G -> V (in Ref. 3; BAC31956). FT CONFLICT 551 551 C -> Y (in Ref. 3; BAC27911). FT CONFLICT 598 598 T -> N (in Ref. 3; BAC27911). SQ SEQUENCE 600 AA; 66775 MW; 5F92E65984746B30 CRC64; MPARGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIQR RSRDARGPGN SAKDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE AAAAGPLGPP TKPPSAWRWK SAQGKEPSGH LRRRDPTDPQ LFFPTSEGGE MSSKRDGIPQ SRQEHSVKTE PRDLFYWPRR TGQLQDSQHR PSAVHEGRTL APPGRALPQN GSADDWVPDQ GGPRRGNTTR RVRLKNPFYP LTQESYGAYA VMCLSVVIFG TGIIGNLAVM CIVCHNYYMR SISNSLLANL AFWDFLIIFF CLPLVIFHEL TKKWLLEDFS CKIVPYIEVA SLGVTTFTLC ALCIDRFRAA TNVQMYYEMI ENCSSTTAKL AVIWVGALLL ALPEVVLRQL SKEDLGFSGQ APAERCVIKI SPDLPDTIYV LALTYDGARL WWYFGCYFCL PTLFTITCSL VTARKIRKAE KASTRGNKRQ IHLESQMNCT VVALTILYGF CIIPENICNI VTAYMATGVS QQTMDLLNII SQFLLFFKSC VTPVLLFCLC RPFSRAFMEC CCCCCEECIQ KSSTVTSDDN DNEYTTELEL SPFSTIRREM STFASVGTHC // ID ADMR_HUMAN STANDARD; PRT; 404 AA. AC O15218; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 18-APR-2006, entry version 49. DE Adrenomedullin receptor (AM-R). GN Name=ADMR; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=98042541; PubMed=9367907; DOI=10.1006/bbrc.1997.7631; RA Haenze J., Dittrich K., Dotsch J., Rascher W.; RT "Molecular cloning of a novel human receptor gene with homology to the RT rat adrenomedullin receptor and high expression in heart and immune RT system."; RL Biochem. Biophys. Res. Commun. 240:183-188(1997). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Colon; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for adrenomedullin. The activity of this CC receptor is mediated by G proteins which activate adenylate CC cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, CC immune system, adrenal gland and liver. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y13583; CAA73910.1; -; mRNA. DR EMBL; AY268434; AAP23201.1; -; Genomic_DNA. DR EMBL; BC034761; AAH34761.1; -; mRNA. DR PIR; JC5784; JC5784. DR UniGene; Hs.483909; -. DR Ensembl; ENSG00000166856; Homo sapiens. DR HGNC; HGNC:13708; ADMR. DR MIM; 605307; gene. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0004888; F:transmembrane receptor activity; TAS. DR GO; GO:0007166; P:cell surface receptor linked signal transdu...; TAS. DR InterPro; IPR001350; G10D_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF171; G10D_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00643; G10DORPHANR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 404 Adrenomedullin receptor. FT /FTId=PRO_0000069112. FT TOPO_DOM 1 57 Extracellular (Potential). FT TRANSMEM 58 79 1 (Potential). FT TOPO_DOM 80 90 Cytoplasmic (Potential). FT TRANSMEM 91 113 2 (Potential). FT TOPO_DOM 114 127 Extracellular (Potential). FT TRANSMEM 128 149 3 (Potential). FT TOPO_DOM 150 170 Cytoplasmic (Potential). FT TRANSMEM 171 193 4 (Potential). FT TOPO_DOM 194 217 Extracellular (Potential). FT TRANSMEM 218 239 5 (Potential). FT TOPO_DOM 240 258 Cytoplasmic (Potential). FT TRANSMEM 259 280 6 (Potential). FT TOPO_DOM 281 299 Extracellular (Potential). FT TRANSMEM 300 320 7 (Potential). FT TOPO_DOM 321 404 Cytoplasmic (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT CARBOHYD 37 37 N-linked (GlcNAc...) (Potential). FT DISULFID 126 202 By similarity. SQ SEQUENCE 404 AA; 45323 MW; EF187ECFDF2DC6C1 CRC64; MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS // ID CCR3_CAVPO STANDARD; PRT; 358 AA. AC Q9Z2I3; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 07-MAR-2006, entry version 28. DE C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) DE (CKR3) (CD193 antigen). GN Name=CCR3; Synonyms=CMKBR3; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=99049845; PubMed=9834099; RA Sabroe I., Conroy D.M., Gerard N.P., Li Y., Collins P.D., Post T.W., RA Jose P.J., Williams T.J., Gerard C.J., Ponath P.D.; RT "Cloning and characterization of the guinea pig eosinophil eotaxin RT receptor, C-C chemokine receptor-3: blockade using a monoclonal RT antibody in vivo."; RL J. Immunol. 161:6139-6147(1998). CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to eotaxin, CC MCP-3, MCP-4 and RANTES and subsequently transduces a signal by CC increasing the intracellular calcium ions level (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF060698; AAC80428.1; -; Genomic_DNA. DR InterPro; IPR002238; CC_3_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01108; CHEMOKINER3. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 358 C-C chemokine receptor type 3. FT /FTId=PRO_0000069237. FT TOPO_DOM 1 43 Extracellular (Potential). FT TRANSMEM 44 64 Potential. FT TOPO_DOM 65 74 Cytoplasmic (Potential). FT TRANSMEM 75 95 Potential. FT TOPO_DOM 96 112 Extracellular (Potential). FT TRANSMEM 113 133 Potential. FT TOPO_DOM 134 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 Potential. FT TOPO_DOM 176 206 Extracellular (Potential). FT TRANSMEM 207 227 Potential. FT TOPO_DOM 228 243 Cytoplasmic (Potential). FT TRANSMEM 244 264 Potential. FT TOPO_DOM 265 287 Extracellular (Potential). FT TRANSMEM 288 308 Potential. FT TOPO_DOM 309 358 Cytoplasmic (Potential). SQ SEQUENCE 358 AA; 41623 MW; 7B73FAB7A3BC3670 CRC64; MATYPEEAEL ETEFPGTTFY DYEFAQPCFK VSITDLGAQF LPSLFSLVFI VGLLGNITVI VVLTKYQKLK IMTNIYLLNL AISDLLFLFT LPFWTYYVHW NKWVFGHFMC KIISGLYYVG LFSEIFFIIL LTIDRYLAIV HAVFALRTRT VTFGIITSVI TWVLAVLAAL PEFMFYGTQG HFEVLFCGPS YPEKKEHHWK RFQALRMNIF GLALPLLIMI ICYTGIIKTL LRCPSKKKYK AIRLIFVIMV VFFVFWTPYN LLLLFSAFDL SFLDDCERSK QLDMAKHVTE VIAHTHCCIN PIIYAFVGER FQKYLRHFLH RNVTMHLSKY IPFFTSEKLE RSSSISPSSG DPELSVVF // ID CCR1_MACFA STANDARD; PRT; 355 AA. AC Q2Y2P0; DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot. DT 20-DEC-2005, sequence version 1. DT 18-APR-2006, entry version 6. DE C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) DE (CD191 antigen). GN Name=CCR1; OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=16204626; DOI=10.1189/jlb.0605326; RA Gupta S., Schulz-Maronde S., Kutzleb C., Richter R., Forssmann W.G., RA Kapp A., Forssmann U., Elsner J.; RT "Cloning, expression, and functional characterization of cynomolgus RT monkey (Macaca fascicularis) CC chemokine receptor 1."; RL J. Leukoc. Biol. 78:1175-1184(2005). CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, CC RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and CC subsequently transduces a signal by increasing the intracellular CC calcium ions level. Responsible for affecting stem cell CC proliferation (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; DQ008589; AAY56400.1; -; mRNA. DR InterPro; IPR002236; CC_1_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01106; CHEMOKINER1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 355 C-C chemokine receptor type 1. FT /FTId=PRO_0000069229. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 60 1 (Potential). FT TOPO_DOM 61 64 Cytoplasmic (Potential). FT TRANSMEM 65 91 2 (Potential). FT TOPO_DOM 92 107 Extracellular (Potential). FT TRANSMEM 108 129 3 (Potential). FT TOPO_DOM 130 146 Cytoplasmic (Potential). FT TRANSMEM 147 171 4 (Potential). FT TOPO_DOM 172 197 Extracellular (Potential). FT TRANSMEM 198 223 5 (Potential). FT TOPO_DOM 224 239 Cytoplasmic (Potential). FT TRANSMEM 240 264 6 (Potential). FT TOPO_DOM 265 281 Extracellular (Potential). FT TRANSMEM 282 305 7 (Potential). FT TOPO_DOM 306 355 Cytoplasmic (Potential). FT DISULFID 106 183 By similarity. SQ SEQUENCE 355 AA; 41165 MW; F56695FE80E2EE51 CRC64; METPDTTENY DMITEFDYGD ATPCHKVNER AILAQLLPPL YSLVFVIGVV GNLLVVLVLV QYKRLKNMTN IYLLNLAISD LLFLFTLPFL IYYKSTDDWI FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASSPLMY FSKTQWNIVR HSCNLHFPYE SFQQWKLFQA LKLNLFGLVL PLLVMIVCYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL FWTPYNLTEL ISVFQEFLFT HLCEQNRQLD LAMEVTEVIA NMHCCVNPVI YAFAGERFRK YLRQLFHRRV AVHLVKWLPF LSGDRLERVS STSPSTGEHE LSAGL // ID CCR2_HUMAN STANDARD; PRT; 374 AA. AC P41597; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 02-MAY-2006, entry version 61. DE C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) DE (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD192 DE antigen). GN Name=CCR2; Synonyms=CMKBR2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=94195821; PubMed=8146186; RA Charo I.F., Myers S.J., Herman A., Franci C., Connolly A.J., RA Coughlin S.R.; RT "Molecular cloning and functional expression of two monocyte RT chemoattractant protein 1 receptors reveals alternative splicing of RT the carboxyl-terminal tails."; RL Proc. Natl. Acad. Sci. U.S.A. 91:2752-2756(1994). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=94324942; PubMed=8048929; RA Yamagami S., Tokuda Y., Ishii K., Tamaka H., Endo N.; RT "cDNA cloning and functional expression of a human monocyte RT chemoattractant protein 1 receptor."; RL Biochem. Biophys. Res. Commun. 202:1156-1162(1994). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=97150864; PubMed=8995400; DOI=10.1074/jbc.272.2.1038; RA Wong L.-M., Myers S.J., Tsou C.-L., Gosling J., Arai H., Charo I.F.; RT "Organization and differential expression of the human monocyte RT chemoattractant protein 1 receptor gene. Evidence for the role of the RT carboxyl-terminal tail in receptor trafficking."; RL J. Biol. Chem. 272:1038-1045(1997). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-64 AND GLU-355. RA Rieder M.J., Armel T.Z., Carrington D.P., Ozuna M., Kuldanek S.A., RA Rajkumar N., Toth E.J., Yi Q., Nickerson D.A.; RT "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW- RT FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Human chromosome 3 international sequencing consortium; RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP SULFATION SITE TYR-26, AND N-GLYCOSYLATION. RX MEDLINE=20501139; PubMed=11046064; RA Preobrazhensky A.A., Dragan S., Kawano T., Gavrilin M.A., Gulina I.V., RA Chakravarty L., Kolattukudy P.E.; RT "Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that RT has tyrosine sulfation in a conserved extracellular N-terminal RT region."; RL J. Immunol. 165:5295-5303(2000). RN [8] RP VARIANT ILE-64. RX MEDLINE=97400624; PubMed=9252328; DOI=10.1126/science.277.5328.959; RA Smith M.W., Dean M., Carrington M., Winkler C., Huttley G.A., RA Lomb D.A., Goedert J.J., O'Brien T.R., Jacobson L.P., Kaslow R., RA Buchbinder S., Vittinghoff E., Vlahov D., Hoots K., Hilgartner M.W., RA O'Brien S.J.; RT "Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 RT infection and disease progression."; RL Science 277:959-965(1997). RN [9] RP VARIANT ILE-64. RX MEDLINE=98324746; PubMed=9662369; DOI=10.1038/nm0798-786; RA Mummidi S., Ahuja S.S., Gonzalez E., Anderson S.A., Santiago E.N., RA Stephan K.T., Craig F.E., O'Connell P., Tryon V., Clark R.A., RA Dolan M.J., Ahuja S.K.; RT "Genealogy of the CCR5 locus and chemokine system gene variants RT associated with altered rates of HIV-1 disease progression."; RL Nat. Med. 4:786-793(1998). CC -!- FUNCTION: Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. CC Transduces a signal by increasing the intracellular calcium ions CC level. Alternative coreceptor with CD4 for HIV-1 infection. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=A; CC IsoId=P41597-1; Sequence=Displayed; CC Name=B; CC IsoId=P41597-2; Sequence=VSP_001893; CC -!- PTM: N-glycosylated. CC -!- POLYMORPHISM: Variations in CCR2 are associated with relative CC resistance to immunodeficiency virus type 1 (resistance to HIV-1) CC [MIM:609423]. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U03882; AAA19119.1; -; mRNA. DR EMBL; U03905; AAA19120.1; -; mRNA. DR EMBL; D29984; BAA06253.1; -; mRNA. DR EMBL; U80924; AAC51637.1; -; Genomic_DNA. DR EMBL; U80924; AAC51636.1; -; Genomic_DNA. DR EMBL; AF545480; AAN16400.1; -; Genomic_DNA. DR EMBL; U95626; AAB57791.1; -; Genomic_DNA. DR EMBL; U95626; AAB57792.1; -; Genomic_DNA. DR EMBL; BC074751; AAH74751.1; -; mRNA. DR PIR; I38450; I38450. DR PIR; JC2443; JC2443. DR UniGene; Hs.395; -. DR UniGene; Hs.511794; -. DR PDB; 1KAD; Model; A=1-343. DR PDB; 1KP1; Model; A=1-343. DR HGNC; HGNC:1603; CCR2. DR MIM; 601267; gene. DR MIM; 609423; phenotype. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0005625; C:soluble fraction; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; TAS. DR GO; GO:0006968; P:cellular defense response; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR GO; GO:0007259; P:JAK-STAT cascade; TAS. DR GO; GO:0007194; P:negative regulation of adenylate cyclase ac...; TAS. DR InterPro; IPR002237; CC_chemok_rcpt_2. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01107; CHEMOKINER2. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW 3D-structure; Alternative splicing; G-protein coupled receptor; KW Glycoprotein; Membrane; Polymorphism; Receptor; Sulfation; Transducer; KW Transmembrane. FT CHAIN 1 374 C-C chemokine receptor type 2. FT /FTId=PRO_0000069232. FT TOPO_DOM 1 42 Extracellular (Potential). FT TRANSMEM 43 70 1 (Potential). FT TOPO_DOM 71 80 Cytoplasmic (Potential). FT TRANSMEM 81 100 2 (Potential). FT TOPO_DOM 101 114 Extracellular (Potential). FT TRANSMEM 115 136 3 (Potential). FT TOPO_DOM 137 153 Cytoplasmic (Potential). FT TRANSMEM 154 178 4 (Potential). FT TOPO_DOM 179 206 Extracellular (Potential). FT TRANSMEM 207 226 5 (Potential). FT TOPO_DOM 227 243 Cytoplasmic (Potential). FT TRANSMEM 244 268 6 (Potential). FT TOPO_DOM 269 285 Extracellular (Potential). FT TRANSMEM 286 309 7 (Potential). FT TOPO_DOM 310 374 Cytoplasmic (Potential). FT MOD_RES 26 26 Sulfotyrosine. FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT DISULFID 32 277 FT DISULFID 113 190 FT VARSPLIC 314 374 SLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGR FT GKGKSIGRAPEASLQDKEGA -> RYLSVFFRKHITKRFCK FT QCPVFYRETVDGVTSTNTPSTGEQEVSAGL (in FT isoform B). FT /FTId=VSP_001893. FT VARIANT 45 45 L -> V (in dbSNP:4987052). FT /FTId=VAR_020066. FT VARIANT 64 64 V -> I (confers relative resistance to FT infection by HIV-1; delay in disease FT progression in African Americans but not FT in Caucasians; dbSNP:1799864). FT /FTId=VAR_014339. FT VARIANT 355 355 G -> E (in dbSNP:3918387). FT /FTId=VAR_014340. FT TURN 2 6 FT STRAND 7 7 FT STRAND 9 9 FT STRAND 12 14 FT STRAND 16 16 FT STRAND 18 18 FT TURN 20 23 FT STRAND 28 28 FT STRAND 30 31 FT STRAND 36 36 FT TURN 37 40 FT HELIX 41 69 FT STRAND 70 70 FT STRAND 75 76 FT HELIX 77 93 FT TURN 94 94 FT HELIX 95 101 FT TURN 102 103 FT STRAND 104 105 FT TURN 107 108 FT HELIX 109 143 FT TURN 145 148 FT STRAND 150 150 FT TURN 151 152 FT STRAND 154 154 FT TURN 155 155 FT HELIX 156 177 FT STRAND 178 178 FT STRAND 181 181 FT STRAND 184 184 FT TURN 185 188 FT STRAND 189 189 FT STRAND 191 193 FT HELIX 194 196 FT TURN 197 198 FT TURN 200 201 FT HELIX 202 210 FT TURN 211 211 FT HELIX 212 224 FT STRAND 225 225 FT TURN 228 229 FT STRAND 230 230 FT STRAND 234 236 FT TURN 238 238 FT HELIX 239 255 FT HELIX 258 265 FT TURN 266 267 FT STRAND 268 269 FT TURN 270 271 FT STRAND 277 278 FT STRAND 283 285 FT STRAND 289 290 FT TURN 292 292 FT HELIX 293 316 FT HELIX 318 328 FT STRAND 333 335 FT STRAND 339 339 FT HELIX 340 343 FT TURN 344 345 SQ SEQUENCE 374 AA; 41915 MW; F865E0D39E74CF0F CRC64; MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS LVFIFGFVGN MLVVLILINC KKLKCLTDIY LLNLAISDLL FLITLPLWAH SAANEWVFGN AMCKLFTGLY HIGYFGGIFF IILLTIDRYL AIVHAVFALK ARTVTFGVVT SVITWLVAVF ASVPGIIFTK CQKEDSVYVC GPYFPRGWNN FHTIMRNILG LVLPLLIMVI CYSGILKTLL RCRNEKKRHR AVRVIFTIMI VYFLFWTPYN IVILLNTFQE FFGLSNCEST SQLDQATQVT ETLGMTHCCI NPIIYAFVGE KFRSLFHIAL GCRIAPLQKP VCGGPGVRPG KNVKVTTQGL LDGRGKGKSI GRAPEASLQD KEGA // ID CCR4_CANFA STANDARD; PRT; 360 AA. AC Q8MJW8; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 02-MAY-2006, entry version 20. DE C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4). GN Name=CCR4; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=12459162; DOI=10.1016/S0165-2427(02)00232-5; RA Maeda S., Okayama T., Omori K., Masuda K., Sakaguchi M., Ohno K., RA Tsujimoto H.; RT "Expression of CC chemokine receptor 4 (CCR4) mRNA in canine atopic RT skin lesion."; RL Vet. Immunol. Immunopathol. 90:145-154(2002). CC -!- FUNCTION: High affinity receptor for the C-C type chemokines CC CCL17/TARC and CCL22/MDC. The activity of this receptor is CC mediated by G(i) proteins which activate a phosphatidylinositol- CC calcium second messenger system. Could play a role in CC lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, CC could mediate hippocampal-neuron survival (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in thymus, spleen, heart, small CC intestine and lymph node. CC -!- PTM: In natural killer cells, CCL22 binding induces CC phosphorylation on yet undefined Ser/Thr residues, most probably CC by beta-adrenergic receptor kinases 1 and 2 (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB080188; BAC10546.1; -; mRNA. DR UniGene; Cfa.56; -. DR Ensembl; ENSCAFG00000004658; Canis familiaris. DR InterPro; IPR002239; CC_chemok_rcpt_4. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF197; CC_4_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01109; CHEMOKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphorylation; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 360 C-C chemokine receptor type 4. FT /FTId=PRO_0000069244. FT TOPO_DOM 1 39 Extracellular (Potential). FT TRANSMEM 40 67 1 (Potential). FT TOPO_DOM 68 77 Cytoplasmic (Potential). FT TRANSMEM 78 98 2 (Potential). FT TOPO_DOM 99 111 Extracellular (Potential). FT TRANSMEM 112 133 3 (Potential). FT TOPO_DOM 134 150 Cytoplasmic (Potential). FT TRANSMEM 151 175 4 (Potential). FT TOPO_DOM 176 206 Extracellular (Potential). FT TRANSMEM 207 226 5 (Potential). FT TOPO_DOM 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 267 6 (Potential). FT TOPO_DOM 268 284 Extracellular (Potential). FT TRANSMEM 285 308 7 (Potential). FT TOPO_DOM 309 360 Cytoplasmic (Potential). FT CARBOHYD 183 183 N-linked (GlcNAc...) (Potential). FT CARBOHYD 194 194 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 By similarity. SQ SEQUENCE 360 AA; 41355 MW; 69115F5209EC0908 CRC64; MNPTDIADTT LDESIYNNYY LYENIPKPCT KEGIKAFGEL FLPPLYSLVF LFGLLGNSVV VVVLFKYKRL KSMTDVYLLN LAISDLLFVL SLPFWGYYAA DQWVFGLGLC KIISWMYLVG FYSGIFFIML MSIDRYLAIV HAVFSLRART LTYGVITSLA TWSVAVLASL PGLLFSTCYT ERNHTYCKTK YSRNSTRWKV LSSLEINILG LVIPLGTMLF CYSMIIRTLQ HCKNEKKSKA VRMVFAVVAL FLGFWAPYNV VLFLETLVEL EVLQDCTFER HLDYAIQATE TLAFVHCCLN PVIYFFLGEK FRKYLVQLFK TCRGPFMLCQ YCRLLQMYSP DTPSSSYTQS TGDHDLHDAL // ID CCR8_HUMAN STANDARD; PRT; 355 AA. AC P51685; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 18-APR-2006, entry version 50. DE C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (GPR-CY6) DE (GPRCY6) (Chemokine receptor-like 1) (CKR-L1) (TER1) (CMKBRL2) (CC- DE chemokine receptor CHEMR1) (CDw198 antigen). GN Name=CCR8; Synonyms=CKRL1, CMKBR8; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=97040707; PubMed=8886020; DOI=10.1006/bbrc.1996.1595; RA Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.; RT "Molecular cloning and RNA expression of two new human chemokine RT receptor-like genes."; RL Biochem. Biophys. Res. Commun. 227:846-853(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=97131825; PubMed=8977299; RA Samson M., Stordeur P., Labbe O., Soularue P., Vassart G., RA Parmentier M.; RT "Molecular cloning and chromosomal mapping of a novel human gene, RT ChemR1, expressed in T lymphocytes and polymorphonuclear cells and RT encoding a putative chemokine receptor."; RL Eur. J. Immunol. 26:3021-3028(1996). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=97351133; PubMed=9207005; DOI=10.1084/jem.186.1.165; RA Tiffany H.L., Lautens L.L., Gao J.-L., Pease J., Locati M., RA Combadiere C., Modi W., Bonner T.I., Murphy P.M.; RT "Identification of CCR8: a human monocyte and thymus receptor for the RT CC chemokine I-309."; RL J. Exp. Med. 186:165-170(1997). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=98129363; PubMed=9469461; RA Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G.; RT "Identification of CCR8 as the specific receptor for the human beta- RT chemokine I-309: cloning and molecular characterization of murine CCR8 RT as the receptor for TCA-3."; RL J. Immunol. 160:1975-1981(1998). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Nakajima T., Yoshida R., Harada S.; RT "Molecular cloning of a human novel C-C chemokine receptor."; RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP LIGAND-BINDING. RX MEDLINE=98180363; PubMed=9521068; RX DOI=10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.3.CO;2-1; RA Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., RA Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., RA Napolitano M.; RT "Identification of the CC chemokines TARC and macrophage inflammatory RT protein-1 beta as novel functional ligands for the CCR8 receptor."; RL Eur. J. Immunol. 28:582-588(1998). RN [8] RP FUNCTION. RX PubMed=10540332; RX DOI=10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W; RA Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., RA Umland S.P.; RT "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 RT beta are not ligands for human CC-chemokine receptor 8."; RL Eur. J. Immunol. 29:3210-3215(1999). CC -!- FUNCTION: Receptor for the chemokine SCYA1/I-309. May regulate CC monocyte chemotaxis and thymic cell line apoptosis. Alternative CC coreceptor with CD4 for HIV-1 infection. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: Was originally (Ref.7) thought to be a receptor for SCYA3 CC and SCYA17. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Z79782; CAB02142.1; -; Genomic_DNA. DR EMBL; Y08456; CAA69712.1; -; Genomic_DNA. DR EMBL; U45983; AAB61962.1; -; Genomic_DNA. DR EMBL; AF005210; AAB62547.1; -; mRNA. DR EMBL; U62556; AAB05542.1; -; Genomic_DNA. DR EMBL; D49919; BAA23387.1; -; mRNA. DR EMBL; BC069067; AAH69067.1; -; mRNA. DR EMBL; BC074743; AAH74743.1; -; mRNA. DR PIR; JC5067; JC5067. DR UniGene; Hs.113222; -. DR Ensembl; ENSG00000179934; Homo sapiens. DR HGNC; HGNC:1609; CCR8. DR MIM; 601834; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0015026; F:coreceptor activity; TAS. DR GO; GO:0007155; P:cell adhesion; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0006955; P:immune response; TAS. DR InterPro; IPR004068; CC_8_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01530; CHEMOKINER8. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 355 C-C chemokine receptor type 8. FT /FTId=PRO_0000069288. FT TOPO_DOM 1 35 Extracellular (Potential). FT TRANSMEM 36 63 1 (Potential). FT TOPO_DOM 64 73 Cytoplasmic (Potential). FT TRANSMEM 74 93 2 (Potential). FT TOPO_DOM 94 107 Extracellular (Potential). FT TRANSMEM 108 129 3 (Potential). FT TOPO_DOM 130 146 Cytoplasmic (Potential). FT TRANSMEM 147 171 4 (Potential). FT TOPO_DOM 172 202 Extracellular (Potential). FT TRANSMEM 203 222 5 (Potential). FT TOPO_DOM 223 238 Cytoplasmic (Potential). FT TRANSMEM 239 263 6 (Potential). FT TOPO_DOM 264 280 Extracellular (Potential). FT TRANSMEM 281 304 7 (Potential). FT TOPO_DOM 305 355 Cytoplasmic (Potential). FT DISULFID 106 183 By similarity. SQ SEQUENCE 355 AA; 40844 MW; BC14A153CF695361 CRC64; MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL LGNSLVILVL VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV FGTVMCKVVS GFYYIGFYSS MFFITLMSVD RYLAVVHAVY ALKVRTIRMG TTLCLAVWLT AIMATIPLLV FYQVASEDGV LQCYSFYNQQ TLKWKIFTNF KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV LIVVIASLLF WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS VDYIL // ID CCBP2_MOUSE STANDARD; PRT; 378 AA. AC O08707; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1997, sequence version 1. DT 18-APR-2006, entry version 48. DE Chemokine-binding protein 2 (Chemokine-binding protein D6) (C-C DE chemokine receptor D6). GN Name=Ccbp2; Synonyms=D6; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C3H; RX MEDLINE=97284722; PubMed=9139699; DOI=10.1074/jbc.272.19.12495; RA Nibbs R.J., Wylie S.M., Pragnell I.B., Graham G.J.; RT "Cloning and characterization of a novel murine beta chemokine RT receptor, D6. Comparison to three other related macrophage RT inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5."; RL J. Biol. Chem. 272:12495-12504(1997). CC -!- FUNCTION: Receptor for C-C type chemokines including SCY3/MIP1- CC alpha and SCYA4/MIP-1-beta. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y12879; CAA73379.1; -; mRNA. DR UniGene; Mm.258105; -. DR Ensembl; ENSMUSG00000044534; Mus musculus. DR MGI; MGI:1891697; Ccbp2. DR GO; GO:0016493; F:C-C chemokine receptor activity; IDA. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0007165; P:signal transduction; IDA. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 378 Chemokine-binding protein 2. FT /FTId=PRO_0000069220. FT TOPO_DOM 1 49 Extracellular (Potential). FT TRANSMEM 50 70 1 (Potential). FT TOPO_DOM 71 91 Cytoplasmic (Potential). FT TRANSMEM 92 112 2 (Potential). FT TOPO_DOM 113 117 Extracellular (Potential). FT TRANSMEM 118 139 3 (Potential). FT TOPO_DOM 140 161 Cytoplasmic (Potential). FT TRANSMEM 162 182 4 (Potential). FT TOPO_DOM 183 216 Extracellular (Potential). FT TRANSMEM 217 237 5 (Potential). FT TOPO_DOM 238 249 Cytoplasmic (Potential). FT TRANSMEM 250 270 6 (Potential). FT TOPO_DOM 271 292 Extracellular (Potential). FT TRANSMEM 293 313 7 (Potential). FT TOPO_DOM 314 378 Cytoplasmic (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 116 194 By similarity. SQ SEQUENCE 378 AA; 43256 MW; 7A125FF3C7B2F5E0 CRC64; MPTVASPLPL TTVGSENSSS IYDYDYLDDM TILVCRKDEV LSFGRVFLPV VYSLIFVLGL AGNLLLLVVL LHSAPRRRTM ELYLLNLAVS NLLFVVTMPF WAISVAWHWV FGSFLCKVIS TLYSINFYCG IFFITCMSLD KYLEIVHAQP LHRPKAQFRN LLLIVMVWIT SLAISVPEMV FVQIHQTLDG VWHCYADFGG HATIWKLYLR FQLNLLGFLL PLLAMIFFYS RIGCVLVRLR PPGQGRALRM AAALVIVFFM LWFPYYLTLF LHSLLDLHVF GNCEISHRLD YTLQVTESLA FSHCCFTPVL YAFCSHRFRR YLKAFLSVML RWHQAPGTPS SNHSESSRVT AQEDVVSMND LGERQSEDSL NKGEMGNT // ID XCR1_HUMAN STANDARD; PRT; 333 AA. AC P46094; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 18-APR-2006, entry version 53. DE Chemokine XC receptor 1 (XC chemokine receptor 1) (Lymphotactin DE receptor) (G-protein coupled receptor 5). GN Name=XCR1; Synonyms=CCXCR1, GPR5; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=95134353; PubMed=7832990; RA Heiber M., Docherty J.M., Shah G., Nguyen T., Cheng R., Heng H.H.Q., RA Marchese A., Tsui L.-C., Shi X., George S.R., O'Dowd B.F.; RT "Isolation of three novel human genes encoding G protein-coupled RT receptors."; RL DNA Cell Biol. 14:25-35(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Warren C.N., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP CHARACTERIZATION. RX MEDLINE=98298178; PubMed=9632725; DOI=10.1074/jbc.273.26.16551; RA Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O.; RT "Identification of single C motif-1/lymphotactin receptor XCR1."; RL J. Biol. Chem. 273:16551-16554(1998). CC -!- FUNCTION: Receptor for chemokines SCYC1 and SCYC2. Subsequently CC transduces a signal by increasing the intracellular calcium ions CC level. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L36149; AAA62837.1; -; Genomic_DNA. DR EMBL; AY275469; AAP32301.1; -; Genomic_DNA. DR EMBL; BC069075; AAH69075.1; -; mRNA. DR EMBL; BC069589; AAH69589.1; -; mRNA. DR PIR; I65989; I65989. DR UniGene; Hs.248116; -. DR Ensembl; ENSG00000173578; Homo sapiens. DR HGNC; HGNC:1625; XCR1. DR MIM; 600552; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005393; Lymphotact_rcpt. DR PANTHER; PTHR19264:SF181; Lymphtact_recept; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01568; LYMPHOTACTNR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 333 Chemokine XC receptor 1. FT /FTId=PRO_0000070221. FT TOPO_DOM 1 31 Extracellular (Potential). FT TRANSMEM 32 59 1 (Potential). FT TOPO_DOM 60 69 Cytoplasmic (Potential). FT TRANSMEM 70 89 2 (Potential). FT TOPO_DOM 90 103 Extracellular (Potential). FT TRANSMEM 104 125 3 (Potential). FT TOPO_DOM 126 142 Cytoplasmic (Potential). FT TRANSMEM 143 167 4 (Potential). FT TOPO_DOM 168 190 Extracellular (Potential). FT TRANSMEM 191 209 5 (Potential). FT TOPO_DOM 210 225 Cytoplasmic (Potential). FT TRANSMEM 226 250 6 (Potential). FT TOPO_DOM 251 267 Extracellular (Potential). FT TRANSMEM 268 291 7 (Potential). FT TOPO_DOM 292 333 Cytoplasmic (Potential). FT DISULFID 102 175 By similarity. SQ SEQUENCE 333 AA; 38508 MW; C84E7A3EF919CFA5 CRC64; MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYSSIFFL TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY // ID CCR10_HUMAN STANDARD; PRT; 362 AA. AC P46092; Q6T7X2; Q9NZG2; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 29-MAR-2005, sequence version 3. DT 18-APR-2006, entry version 50. DE C-C chemokine receptor type 10 (C-C CKR-10) (CC-CKR-10) (CCR-10) (G- DE protein coupled receptor 2). GN Name=CCR10; Synonyms=GPR2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RX MEDLINE=20191997; PubMed=10725696; RA Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., RA Clark-Lewis I., Gerard C.; RT "Identification of the orphan receptor G-protein-coupled receptor 2 as RT CCR10, a specific receptor for the chemokine ESkine."; RL J. Immunol. 164:3460-3464(2000). RN [2] RP NUCLEOTIDE SEQUENCE, AND CHARACTERIZATION. RX MEDLINE=20191998; PubMed=10725697; RA Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., RA Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., RA Lehmann P., Oldham E., Zlotnik A.; RT "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, RT CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)."; RL J. Immunol. 164:3465-3470(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362. RX MEDLINE=95154831; PubMed=7851889; RA Marchese A., Docherty J.M., Nguyen T., Heiber M., Cheng R., RA Heng H.H.Q., Tsui L.-C., Shi X., George S.R., O'Dowd B.F.; RT "Cloning of human genes encoding novel G protein-coupled receptors."; RL Genomics 23:609-618(1994). RN [5] RP LIGAND-BINDING, AND TISSUE SPECIFICITY. RX MEDLINE=20357357; PubMed=10781587; DOI=10.1074/jbc.M001461200; RA Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D., RA Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J., RA Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A.; RT "Identification of a novel chemokine (CCL28), which binds CCR10 RT (GPR2)."; RL J. Biol. Chem. 275:22313-22323(2000). RN [6] RP LIGAND-BINDING. RX MEDLINE=20432268; PubMed=10975800; RA Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., RA Vierra M.A., Genovese M.C., Butcher E.C., Soler D.; RT "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial RT cells in mucosal tissues."; RL J. Immunol. 165:2943-2949(2000). CC -!- FUNCTION: Receptor for chemokines SCYA27 and SCYA28. Subsequently CC transduces a signal by increasing the intracellular calcium ions CC level and stimulates chemotaxis in a pre-B cell line. CC -!- INTERACTION: CC P48634:BAT2; NbExp=1; IntAct=EBI-348022, EBI-347545; CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed at high levels in adult testis, CC small intestine, fetal lung, fetal kidney. Weaker expression was CC observed in many other adult tissues including spleen, thymus, CC lymph node, Peyer patches, colon, heart, ovary, peripheral blood CC lymphocytes, thyroid and spinal cord. Also expressed by CC melanocytes, dermal fibroblasts, dermal microvascular endothelial CC cells. Also detected in T-cells and in skin-derived Langerhans CC cells. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF215981; AAF63709.1; -; mRNA. DR EMBL; AF208237; AAF72871.1; -; mRNA. DR EMBL; AY429103; AAR07898.1; -; mRNA. DR EMBL; U13667; AAA64593.1; -; Genomic_DNA. DR UniGene; Hs.278446; -. DR IntAct; P46092; -. DR Ensembl; ENSG00000184451; Homo sapiens. DR HGNC; HGNC:4474; CCR10. DR MIM; 600240; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR005382; CC_10_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF180; CC_10_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01557; CHEMOKINER10. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 362 C-C chemokine receptor type 10. FT /FTId=PRO_0000069293. FT TOPO_DOM 1 52 Extracellular (Potential). FT TRANSMEM 53 68 1 (Potential). FT TOPO_DOM 69 78 Cytoplasmic (Potential). FT TRANSMEM 79 99 2 (Potential). FT TOPO_DOM 100 114 Extracellular (Potential). FT TRANSMEM 115 136 3 (Potential). FT TOPO_DOM 137 159 Cytoplasmic (Potential). FT TRANSMEM 160 179 4 (Potential). FT TOPO_DOM 180 203 Extracellular (Potential). FT TRANSMEM 204 225 5 (Potential). FT TOPO_DOM 226 247 Cytoplasmic (Potential). FT TRANSMEM 248 269 6 (Potential). FT TOPO_DOM 270 290 Extracellular (Potential). FT TRANSMEM 291 313 7 (Potential). FT TOPO_DOM 314 362 Cytoplasmic (Potential). FT DISULFID 113 191 By similarity. FT CONFLICT 51 51 V -> L (in Ref. 4). FT CONFLICT 235 235 Missing (in Ref. 2). FT CONFLICT 330 330 C -> S (in Ref. 1 and 4). SQ SEQUENCE 362 AA; 38416 MW; 736EB9B639AEA99A CRC64; MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT VAALGLAGNG LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA GALQGWSLGS ATCRTISGLY SASFHAGFLF LACISADRYV AIARALPAGP RPSTPGRAHL VSVIVWLLSL LLALPALLFS QDGQREGQRR CRLIFPEGLT QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP ERRRALRVVV ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS APTETHSLSW DN // ID CXCR5_MOUSE STANDARD; PRT; 374 AA. AC Q04683; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 18-APR-2006, entry version 50. DE C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt'S lymphoma DE receptor 1 homolog) (CD185 antigen). GN Name=Blr1; Synonyms=Cxcr5, Gpcr6; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/c; TISSUE=Liver; RX MEDLINE=94009211; PubMed=8405054; RA Kaiser E., Foerster R., Wolf I., Epensperger C., Kuehl W.M., Lipp M.; RT "The G protein-coupled receptor BLR1 is involved in murine B cell RT differentiation and is also expressed in neuronal tissues."; RL Eur. J. Immunol. 23:2532-2539(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 151-269. RC TISSUE=Testis; RX MEDLINE=94116980; PubMed=8288218; RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., RA Copeland N.G., Jenkins N.A.; RT "Identification, chromosomal location, and genome organization of RT mammalian G-protein-coupled receptors."; RL Genomics 18:175-184(1993). RN [3] RP CHARACTERIZATION. RX MEDLINE=97133211; PubMed=8978608; DOI=10.1016/S0092-8674(00)81798-5; RA Foerster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M.; RT "A putative chemokine receptor, BLR1, directs B cell migration to RT defined lymphoid organs and specific anatomic compartments of the RT spleen."; RL Cell 87:1037-1047(1996). RN [4] RP LIGAND-BINDING. RX MEDLINE=98146056; PubMed=9486651; DOI=10.1038/35876; RA Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., RA Williams L.T.; RT "A B-cell-homing chemokine made in lymphoid follicles activates RT Burkitt's lymphoma receptor-1."; RL Nature 391:799-803(1998). CC -!- FUNCTION: Cytokine receptor that binds to B-lymphocyte CC chemoattractant (BLC). Involved in B-cell migration into B-cell CC follicles of spleen and Peyer patches, but not in those of CC mesentric or peripheral lymph nodes. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Mainly in spleen, in resting B-cells. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X71788; CAA50673.1; -; mRNA. DR EMBL; L20332; AAA16852.1; -; mRNA. DR PIR; S42628; S42628. DR UniGene; Mm.6246; -. DR Ensembl; ENSMUSG00000047880; Mus musculus. DR MGI; MGI:103567; Blr1. DR GO; GO:0048535; P:lymph node development; IMP. DR InterPro; IPR000248; Angtn2_rcpt. DR InterPro; IPR001053; CXC_5_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF184; CXC_5_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00564; CXCCHMKINER5. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW B-cell activation; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 374 C-X-C chemokine receptor type 5. FT /FTId=PRO_0000069361. FT TOPO_DOM 1 57 Extracellular (Potential). FT TRANSMEM 58 78 1 (Potential). FT TOPO_DOM 79 90 Cytoplasmic (Potential). FT TRANSMEM 91 111 2 (Potential). FT TOPO_DOM 112 126 Extracellular (Potential). FT TRANSMEM 127 147 3 (Potential). FT TOPO_DOM 148 169 Cytoplasmic (Potential). FT TRANSMEM 170 190 4 (Potential). FT TOPO_DOM 191 221 Extracellular (Potential). FT TRANSMEM 222 242 5 (Potential). FT TOPO_DOM 243 261 Cytoplasmic (Potential). FT TRANSMEM 262 282 6 (Potential). FT TOPO_DOM 283 306 Extracellular (Potential). FT TRANSMEM 307 327 7 (Potential). FT TOPO_DOM 328 374 Cytoplasmic (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT CARBOHYD 198 198 N-linked (GlcNAc...) (Potential). FT DISULFID 124 204 Potential. SQ SEQUENCE 374 AA; 42101 MW; 385258420C1EDE30 CRC64; MNYPLTLDMG SITYNMDDLY KELAFYSNST EIPLQDSNFC STVEGPLLTS FKAVFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LVACIAVDRY LAIVHAVHAY RRRRLLSIHI TCTAIWLAGF LFALPELLFA KVGQPHNNDS LPQCTFSQEN EAETRAWFTS RFLYHIGGFL LPMLVMGWCY VGVVHRLLQA QRRPQRQKAV RVAILVTSIF FLCWSPYHIV IFLDTLERLK AVNSSCELSG YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPNWRKS SLSESENATS LTTF // ID CXCR2_MOUSE STANDARD; PRT; 359 AA. AC P35343; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 1. DT 18-APR-2006, entry version 55. DE High affinity interleukin-8 receptor B (IL-8R B) (CXCR-2) (GRO/MGSA DE receptor) (CD182 antigen). GN Name=Il8rb; Synonyms=Cmkar2, Cxcr2, Gpcr16; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94117014; PubMed=8288247; RA Cerretti D.P., Nelson N., Kozlosky C.J., Morrissey P.J., RA Copeland N.G., Gilbert D.J., Jenkins N.A., Dosik J.K., Mock B.A.; RT "The murine homologue of the human interleukin-8 receptor type B maps RT near the Ity-Lsh-Bcg disease resistance locus."; RL Genomics 18:410-413(1993). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94308043; PubMed=7518426; RA Suzuki H., Prado G.N., Wilkinson N., Navarro J.; RT "The N-terminus of interleukin-8 (IL-8) receptor confers high affinity RT binding to human IL-8."; RL J. Biol. Chem. 269:18263-18266(1994). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c; RX MEDLINE=95050766; PubMed=7961909; RA Bozic C.R., Gerard N.P., von Uexkull-Guldenband C., RA Kolakowski L.F. Jr., Conklyn M.J., Breslow R., Showell H.J., RA Gerard C.; RT "The murine interleukin 8 type B receptor homologue and its ligands. RT Expression and biological characterization."; RL J. Biol. Chem. 269:29355-29358(1994). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/Sv; RX MEDLINE=95363183; PubMed=7636264; RA Lee J., Cacalano G., Camerato T., Toy K., Moore M.W., Wood W.I.; RT "Chemokine binding and activities mediated by the mouse IL-8 RT receptor."; RL J. Immunol. 155:2158-2164(1995). RN [5] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94252584; PubMed=8194768; DOI=10.1016/0378-1119(94)90278-X; RA Harada A., Kuno K., Nomura H., Mukaida N., Murakami S., Matsushima K.; RT "Cloning of a cDNA encoding a mouse homolog of the interleukin-8 RT receptor."; RL Gene 142:297-300(1994). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Trophoblast; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP NUCLEOTIDE SEQUENCE OF 145-258. RC TISSUE=Testis; RX MEDLINE=94116980; PubMed=8288218; RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., RA Copeland N.G., Jenkins N.A.; RT "Identification, chromosomal location, and genome organization of RT mammalian G-protein-coupled receptors."; RL Genomics 18:175-184(1993). CC -!- FUNCTION: Receptor to interleukin-8, which is a powerful CC neutrophils chemotactic factor. Binding of IL-8 to the receptor CC causes activation of neutrophils. This response is mediated via a CC G-protein that activate a phosphatidylinositol-calcium second CC messenger system. This receptor binds to IL-8 with a high affinity CC and to GRO/MGSA and NAP-2 also with a high affinity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated upon ligand binding; which is required for CC desensitization (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L23637; AAA39305.1; -; Genomic_DNA. DR EMBL; L13239; AAA62109.1; -; Genomic_DNA. DR EMBL; U31207; AAC52239.1; -; Genomic_DNA. DR EMBL; D17630; BAA04536.1; -; mRNA. DR EMBL; BC051677; AAH51677.1; -; mRNA. DR EMBL; L20337; AAA16853.1; -; mRNA. DR PIR; A48921; A48921. DR UniGene; Mm.234466; -. DR Ensembl; ENSMUSG00000026180; Mus musculus. DR MGI; MGI:105303; Il8rb. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0004918; F:interleukin-8 receptor activity; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000174; IL8_rcpt. DR InterPro; IPR000057; IL8B_rcpt. DR PANTHER; PTHR19264:SF183; IL8_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00427; INTRLEUKIN8R. DR PRINTS; PR00573; INTRLEUKN8BR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Receptor; Sensory transduction; Transducer; KW Transmembrane. FT CHAIN 1 359 High affinity interleukin-8 receptor B. FT /FTId=PRO_0000069339. FT TOPO_DOM 1 47 Extracellular (Potential). FT TRANSMEM 48 74 1 (Potential). FT TOPO_DOM 75 83 Cytoplasmic (Potential). FT TRANSMEM 84 104 2 (Potential). FT TOPO_DOM 105 119 Extracellular (Potential). FT TRANSMEM 120 141 3 (Potential). FT TOPO_DOM 142 162 Cytoplasmic (Potential). FT TRANSMEM 163 182 4 (Potential). FT TOPO_DOM 183 207 Extracellular (Potential). FT TRANSMEM 208 230 5 (Potential). FT TOPO_DOM 231 250 Cytoplasmic (Potential). FT TRANSMEM 251 272 6 (Potential). FT TOPO_DOM 273 293 Extracellular (Potential). FT TRANSMEM 294 314 7 (Potential). FT TOPO_DOM 315 359 Cytoplasmic (Potential). FT MOD_RES 346 346 Phosphoserine (By similarity). FT MOD_RES 350 350 Phosphoserine (By similarity). FT MOD_RES 351 351 Phosphoserine (By similarity). FT MOD_RES 352 352 Phosphoserine (By similarity). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT DISULFID 118 195 By similarity. SQ SEQUENCE 359 AA; 40425 MW; 74BD166E9B679F88 CRC64; MGEFKVDKFN IEDFFSGDLD IFNYSSGMPS ILPDAVPCHS ENLEINSYAV VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL PVWAASKVNG WTFGSTLCKI FSYVKEVTFY SSVLLLACIS MDRYLAIVHA TSTLIQKRHL VKFVCIAMWL LSVILALPIL ILRNPVKVNL STLVCYEDVG NNTSRLRVVL RILPQTFGFL VPLLIMLFCY GFTLRTLFKA HMGQKHRAMR VIFAVVLVFL LCWLPYNLVL FTDTLMRTKL IKETCERRDD IDKALNATEI LGFLHSCLNP IIYAFIGQKF RHGLLKIMAT YGLVSKEFLA KEGRPSFVSS SSANTSTTL // ID CXCR1_RAT STANDARD; PRT; 349 AA. AC P70612; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 04-APR-2006, entry version 41. DE High affinity interleukin-8 receptor A (IL-8R A) (CXCR-1) (CD181 DE antigen). GN Name=Il8ra; Synonyms=Cxcr1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Wistar; TISSUE=Lung; RX MEDLINE=97115810; PubMed=8955112; DOI=10.1074/jbc.271.51.32770; RA Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., RA Harrison J.K.; RT "Identification of two rat genes orthologous to the human interleukin- RT 8 receptors."; RL J. Biol. Chem. 271:32770-32776(1996). CC -!- FUNCTION: Receptor to interleukin-8, which is a powerful CC neutrophils chemotactic factor. Binding of IL-8 to the receptor CC causes activation of neutrophils. This response is mediated via a CC G-protein that activate a phosphatidylinositol-calcium second CC messenger system (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U71089; AAC52962.1; -; Genomic_DNA. DR UniGene; Rn.138115; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSRNOG00000014281; Rattus norvegicus. DR RGD; 2905; Il8ra. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000174; IL8_rcpt. DR PANTHER; PTHR19264:SF183; IL8_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00427; INTRLEUKIN8R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Sensory transduction; Transducer; Transmembrane. FT CHAIN 1 349 High affinity interleukin-8 receptor A. FT /FTId=PRO_0000069333. FT TOPO_DOM 1 44 Extracellular (Potential). FT TRANSMEM 45 71 1 (Potential). FT TOPO_DOM 72 80 Cytoplasmic (Potential). FT TRANSMEM 81 101 2 (Potential). FT TOPO_DOM 102 116 Extracellular (Potential). FT TRANSMEM 117 138 3 (Potential). FT TOPO_DOM 139 159 Cytoplasmic (Potential). FT TRANSMEM 160 179 4 (Potential). FT TOPO_DOM 180 204 Extracellular (Potential). FT TRANSMEM 205 225 5 (Potential). FT TOPO_DOM 226 247 Cytoplasmic (Potential). FT TRANSMEM 248 269 6 (Potential). FT TOPO_DOM 270 290 Extracellular (Potential). FT TRANSMEM 291 313 7 (Potential). FT TOPO_DOM 314 349 Cytoplasmic (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT DISULFID 115 192 By similarity. SQ SEQUENCE 349 AA; 39945 MW; 9B1CDCE61568EABA CRC64; MAEAEYFIWI APEGDFEEEF GNITRMLPTG EYFSPCKRVP MTNRQAVVVF YALVFLLSLL GNSLVMLVIL YRRRTRSVTD VYVLNLAIAD LLFSLTLPFL AVSKWKGWIF GTPLCKMVSL LKEVNFFSGI LLLACISVDR YLAIVHATRT LTRKRYLVKF VCMGTWGLSL VLSLPFAIFR QAYKPYRSGT VCYEVLGEAT ADLRITLRGL SHIFGFLLPL FIMLVCYGLT LRTLFKAHMR QKRRAMWVIF AVVLVFLLCC LPYNLVLLSD TLLGAHLIQD TCERRNNIDQ ALYITEILGF SHSCLNPVIY AFVGQSFRHE FLKILANLVH KEVLTHHSAS FRTSLTTIY // ID CCR7_HUMAN STANDARD; PRT; 378 AA. AC P32248; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 2. DT 18-APR-2006, entry version 58. DE C-C chemokine receptor type 7 precursor (C-C CKR-7) (CC-CKR-7) (CCR-7) DE (MIP-3 beta receptor) (EBV-induced G-protein coupled receptor 1) DE (EBI1) (BLR2) (CD197 antigen) (CDw197). GN Name=CCR7; Synonyms=CMKBR7, EBI1, EVI1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=93188173; PubMed=8383238; RA Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., RA Kieff E.; RT "Epstein-Barr virus-induced genes: first lymphocyte-specific G RT protein-coupled peptide receptors."; RL J. Virol. 67:2209-2220(1993). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta; RX MEDLINE=95154835; PubMed=7851893; RA Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., RA Shows T.B., Gray P.W.; RT "Cloning of human and mouse EBI1, a lymphoid-specific G-protein- RT coupled receptor encoded on human chromosome 17q12-q21.2."; RL Genomics 23:643-650(1994). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for the MIP-3-beta chemokine. Probable mediator CC of EBV effects on B-lymphocytes or of normal lymphocyte functions. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in various lymphoid tissues and CC activated B- and T-lymphocytes, strongly up-regulated in B-cells CC infected with Epstein-Barr virus and T-cells infected with CC herpesvirus 6 or 7. CC -!- INDUCTION: By EBV. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L08176; AAA58615.1; -; mRNA. DR EMBL; L31584; AAA74230.1; -; Genomic_DNA. DR EMBL; L31582; AAA74230.1; JOINED; Genomic_DNA. DR EMBL; L31583; AAA74230.1; JOINED; Genomic_DNA. DR EMBL; L31581; AAA74231.1; -; mRNA. DR EMBL; AY587876; AAT52232.1; -; mRNA. DR EMBL; BC035343; AAH35343.1; -; mRNA. DR PIR; A45680; A45680. DR PIR; B55735; B55735. DR UniGene; Hs.370036; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSG00000126353; Homo sapiens. DR HGNC; HGNC:1608; CCR7. DR MIM; 600242; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR InterPro; IPR001718; CC_7_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF189; CC_7_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR00641; CHEMOKINER7. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Signal; KW Transducer; Transmembrane. FT SIGNAL 1 24 Potential. FT CHAIN 25 378 C-C chemokine receptor type 7. FT /FTId=PRO_0000012735. FT TOPO_DOM 25 59 Extracellular (Potential). FT TRANSMEM 60 86 1 (Potential). FT TOPO_DOM 87 95 Cytoplasmic (Potential). FT TRANSMEM 96 116 2 (Potential). FT TOPO_DOM 117 130 Extracellular (Potential). FT TRANSMEM 131 152 3 (Potential). FT TOPO_DOM 153 170 Cytoplasmic (Potential). FT TRANSMEM 171 191 4 (Potential). FT TOPO_DOM 192 219 Extracellular (Potential). FT TRANSMEM 220 247 5 (Potential). FT TOPO_DOM 248 263 Cytoplasmic (Potential). FT TRANSMEM 264 289 6 (Potential). FT TOPO_DOM 290 313 Extracellular (Potential). FT TRANSMEM 314 331 7 (Potential). FT TOPO_DOM 332 378 Cytoplasmic (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT DISULFID 129 210 By similarity. FT CONFLICT 182 183 IW -> SA (in Ref. 1). FT CONFLICT 337 337 L -> I (in Ref. 1). SQ SEQUENCE 378 AA; 42874 MW; D4CB4213841A1BD4 CRC64; MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH IRRSSMSVEA ETTTTFSP // ID CCR6_HUMAN STANDARD; PRT; 374 AA. AC P51684; P78553; Q92846; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 18-APR-2006, entry version 60. DE C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (LARC DE receptor) (GPR-CY4) (GPRCY4) (Chemokine receptor-like 3) (CKR-L3) DE (DRY6) (G-protein coupled receptor 29) (CD196 antigen). GN Name=CCR6; Synonyms=CKRL3, CMKBR6, GPR29, STRL22; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE, AND FUNCTION. RX MEDLINE=97313465; PubMed=9169459; DOI=10.1074/jbc.272.23.14893; RA Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K., RA Nomiyama H., Yoshie O.; RT "Identification of CCR6, the specific receptor for a novel lymphocyte- RT directed CC chemokine LARC."; RL J. Biol. Chem. 272:14893-14898(1997). RN [2] RP NUCLEOTIDE SEQUENCE. RA Lautens L.L., Modi W., Bonner T.I.; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97040707; PubMed=8886020; DOI=10.1006/bbrc.1996.1595; RA Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.; RT "Molecular cloning and RNA expression of two new human chemokine RT receptor-like genes."; RL Biochem. Biophys. Res. Commun. 227:846-853(1996). RN [4] RP NUCLEOTIDE SEQUENCE. RA McCoy R., Perlmutter D.H.; RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97224503; PubMed=9070937; DOI=10.1006/geno.1996.4544; RA Liao F., Lee H.-H., Farber J.M.; RT "Cloning of STRL22, a new human gene encoding a G-protein-coupled RT receptor related to chemokine receptors and located on chromosome RT 6q27."; RL Genomics 40:175-180(1997). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Warren C.N., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pancreas; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to MIP-3- CC alpha/LARC and subsequently transduces a signal by increasing the CC intracellular calcium ions level. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Spleen, lymph nodes, appendix, and fetal CC liver. Expressed in lymphocytes, T-cells and B-cells but not in CC natural killer cells, monocytes or granulocytes. CC -!- INDUCTION: By interleukin-2. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U45984; AAB62714.1; -; Genomic_DNA. DR EMBL; Z79784; CAB02144.1; ALT_INIT; Genomic_DNA. DR EMBL; U60000; AAB06949.1; -; mRNA. DR EMBL; U68030; AAC51124.1; -; mRNA. DR EMBL; U68032; AAC51125.1; -; Genomic_DNA. DR EMBL; AY242126; AAO92293.1; -; mRNA. DR EMBL; AL121935; CAB99328.1; -; Genomic_DNA. DR EMBL; BC037960; AAH37960.1; -; mRNA. DR UniGene; Hs.46468; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSG00000112486; Homo sapiens. DR HGNC; HGNC:1607; CCR6. DR MIM; 601835; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0004872; F:receptor activity; TAS. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; TAS. DR GO; GO:0006928; P:cell motility; TAS. DR GO; GO:0006968; P:cellular defense response; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS. DR GO; GO:0006959; P:humoral immune response; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000190; AT1_rcpt. DR InterPro; IPR004067; CC_6_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF188; CC_6_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00635; ANGIOTENSN1R. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01529; CHEMOKINER6. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 374 C-C chemokine receptor type 6. FT /FTId=PRO_0000069286. FT TOPO_DOM 1 47 Extracellular (Potential). FT TRANSMEM 48 74 1 (Potential). FT TOPO_DOM 75 83 Cytoplasmic (Potential). FT TRANSMEM 84 104 2 (Potential). FT TOPO_DOM 105 119 Extracellular (Potential). FT TRANSMEM 120 141 3 (Potential). FT TOPO_DOM 142 159 Cytoplasmic (Potential). FT TRANSMEM 160 180 4 (Potential). FT TOPO_DOM 181 211 Extracellular (Potential). FT TRANSMEM 212 238 5 (Potential). FT TOPO_DOM 239 254 Cytoplasmic (Potential). FT TRANSMEM 255 279 6 (Potential). FT TOPO_DOM 280 303 Extracellular (Potential). FT TRANSMEM 304 321 7 (Potential). FT TOPO_DOM 322 374 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT DISULFID 118 197 By similarity. FT CONFLICT 60 60 G -> A (in Ref. 4). FT CONFLICT 74 74 Y -> N (in Ref. 4). FT CONFLICT 86 86 L -> V (in Ref. 4). FT CONFLICT 164 164 S -> T (in Ref. 5). FT CONFLICT 182 182 T -> S (in Ref. 4). FT CONFLICT 192 192 Q -> L (in Ref. 4). FT CONFLICT 206 206 E -> V (in Ref. 4). FT CONFLICT 225 225 I -> F (in Ref. 4). FT CONFLICT 370 374 SSFTM -> VVLHYVIES (in Ref. 4). SQ SEQUENCE 374 AA; 42494 MW; D7F963534E990BC4 CRC64; MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT SETADNDNAS SFTM // ID CXCR6_MACFA STANDARD; PRT; 343 AA. AC Q9BDS6; DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 18-APR-2006, entry version 30. DE C-X-C chemokine receptor type 6 (CXC-R6) (CXCR-6) (G-protein coupled DE receptor bonzo) (G-protein coupled receptor STRL33). GN Name=CXCR6; Synonyms=BONZO, STRL33; OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=21134756; PubMed=11242524; DOI=10.1089/08892220150503744; RA Wade-Evans A.M., Russell J., Jenkins A., Javan C.; RT "Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33: RT potential coreceptors for HIV type 1, HIV type 2, and SIV."; RL AIDS Res. Hum. Retroviruses 17:371-375(2001). CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a CC coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF291671; AAK25742.1; -; mRNA. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR002235; CXC_6_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF187; CXC_6_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01105; CXCCHMKINER6. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 343 C-X-C chemokine receptor type 6. FT /FTId=PRO_0000069366. FT TOPO_DOM 1 33 Extracellular (Potential). FT TRANSMEM 34 60 1 (Potential). FT TOPO_DOM 61 69 Cytoplasmic (Potential). FT TRANSMEM 70 90 2 (Potential). FT TOPO_DOM 91 104 Extracellular (Potential). FT TRANSMEM 105 126 3 (Potential). FT TOPO_DOM 127 144 Cytoplasmic (Potential). FT TRANSMEM 145 165 4 (Potential). FT TOPO_DOM 166 188 Extracellular (Potential). FT TRANSMEM 189 216 5 (Potential). FT TOPO_DOM 217 232 Cytoplasmic (Potential). FT TRANSMEM 233 260 6 (Potential). FT TOPO_DOM 261 276 Extracellular (Potential). FT TRANSMEM 277 294 7 (Potential). FT TOPO_DOM 295 343 Cytoplasmic (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 103 181 By similarity. SQ SEQUENCE 343 AA; 39473 MW; 0961328F948E7784 CRC64; MAEYDHYEDD GFLNSFNDSS QEEHQDFLQF RKVFLPCMYL VVFVCGLVGN SLVLVISIFY HKLQSLTDVF LVNLPLADLV FVCTLPFWTY AGIHEWIFGQ VMCKTLLGVY TINFYTSMLI LTCITVDRFI VVVKATKAYN QQAKRMTWGK VICLLIWVIS LLVSLPQIIY GNVFNLDKLI CGYHDEEIST VVLATQMTLG FFLPLLAMIV CYSVIIKTLL HAGGFQKHRS LKIIFLVMAV FLLTQTPFNL VKLIRSTRWE YYAMTSFHYT IIVTEAIAYL RACLNPVLYA FVSLKFRKNF WKLVKDIGCL PYLGVSHQWK SSEDNSKTFS ASHNVEATSM FQL // ID AGTRL_XENLA STANDARD; PRT; 362 AA. AC P32303; Q91383; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 2. DT 04-APR-2006, entry version 43. DE Type-1-like angiotensin II receptor 1 (AT1). OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Heart; RX MEDLINE=93343933; PubMed=7688227; RA Ji H., Sandberg K., Zhang Y., Catt K.J.; RT "Molecular cloning, sequencing and functional expression of an RT amphibian angiotensin II receptor."; RL Biochem. Biophys. Res. Commun. 194:756-762(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Heart; RX MEDLINE=94325348; PubMed=7519446; DOI=10.1016/0167-4781(94)90193-7; RA Nishimatsu S., Koyasu N., Sugaya T., Ohnishi J., Yamagishi T., RA Murakami K., Miyazaki H.; RT "Isolation and characterization of two alternatively spliced RT complementary DNAs encoding a Xenopus laevis angiotensin II RT receptor."; RL Biochim. Biophys. Acta 1218:401-407(1994). CC -!- FUNCTION: Receptor for angiotensin II. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L16463; AAA49647.1; -; mRNA. DR EMBL; S73388; AAD14966.2; -; mRNA. DR EMBL; S73274; AAC60749.1; -; mRNA. DR PIR; JN0694; JN0694. DR UniGene; Xl.436; -. DR InterPro; IPR000248; Angtn2_rcpt. DR InterPro; IPR000190; AT1_rcpt. DR InterPro; IPR001186; BK_rcpt_B1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF177; AT1_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00635; ANGIOTENSN1R. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 362 Type-1-like angiotensin II receptor 1. FT /FTId=PRO_0000069165. FT TOPO_DOM 1 28 Extracellular (Potential). FT TRANSMEM 29 53 1 (Potential). FT TOPO_DOM 54 65 Cytoplasmic (Potential). FT TRANSMEM 66 88 2 (Potential). FT TOPO_DOM 89 103 Extracellular (Potential). FT TRANSMEM 104 125 3 (Potential). FT TOPO_DOM 126 143 Cytoplasmic (Potential). FT TRANSMEM 144 163 4 (Potential). FT TOPO_DOM 164 193 Extracellular (Potential). FT TRANSMEM 194 215 5 (Potential). FT TOPO_DOM 216 239 Cytoplasmic (Potential). FT TRANSMEM 240 261 6 (Potential). FT TOPO_DOM 262 274 Extracellular (Potential). FT TRANSMEM 275 295 7 (Potential). FT TOPO_DOM 296 362 Cytoplasmic (Potential). FT LIPID 361 361 S-palmitoyl cysteine (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 177 177 N-linked (GlcNAc...) (Potential). FT DISULFID 102 181 By similarity. SQ SEQUENCE 362 AA; 41293 MW; 7E0CA09B185E7D57 CRC64; MSNASTVETS DVERIAVNCS KSGMHNYIFI AIPIIYSTIF VVGVFGNSMV VIVIYSYMKM KTVASIFLMN LALSDLCFVI TLPLWAAYTA MHYHWPFGNF LCKVASTAIT LNLYTTVFLL TCLSIDRYSA IVHPMKSRIW RTAMVARLTC VGIWLVAFLA SMPSIIYRQI YLFHDTNQTV CAIVYDSGHI YFMVGMSLAK NIVGFLIPFL IILTSYTLIG KTLKEVYRAQ RARNDDIFKM IVAVVLLFFF CWIPYQVFTF LDVLIQMDVI QNCKMYDIVD TGMPITICIA YFNSCLNPFL YGFFGKNFRK HFLQLIKYIP PKMRTHASVN TKSSLVSSSL SDTKRASKKI ALQMTDNEEH CK // ID BKRB1_PIG STANDARD; PRT; 353 AA. AC Q8HZN9; DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 07-MAR-2006, entry version 22. DE B1 bradykinin receptor (BK-1 receptor) (B1R). GN Name=BDKRB1; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Horlick R.A., Zhao J., Swanson R.N., Webb M.L., Strohl B., RA Baldwin J.J., Auld D.S.; RT "Orthologs of human receptors and methods of use."; RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in CC chronic pain and inflammation (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF540788; AAN16467.1; -; Genomic_DNA. DR InterPro; IPR001186; BK_rcpt_B1. DR InterPro; IPR000496; Brdyknn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF174; BK_receptorB1; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00425; BRADYKININR. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 353 B1 bradykinin receptor. FT /FTId=PRO_0000069185. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 62 1 (Potential). FT TOPO_DOM 63 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT TOPO_DOM 94 110 Extracellular (Potential). FT TRANSMEM 111 131 3 (Potential). FT TOPO_DOM 132 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 4 (Potential). FT TOPO_DOM 176 207 Extracellular (Potential). FT TRANSMEM 208 228 5 (Potential). FT TOPO_DOM 229 251 Cytoplasmic (Potential). FT TRANSMEM 252 272 6 (Potential). FT TOPO_DOM 273 295 Extracellular (Potential). FT TRANSMEM 296 316 7 (Potential). FT TOPO_DOM 317 353 Cytoplasmic (Potential). FT LIPID 330 330 S-palmitoyl cysteine (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT CARBOHYD 185 185 N-linked (GlcNAc...) (Potential). FT DISULFID 109 189 By similarity. SQ SEQUENCE 353 AA; 40146 MW; D496CC6C54EDD88F CRC64; MASQTLVVFQ ASNQSQLPPP NATLCDGAQE AWHLLHKVLP TCVVAICSGG LLGNLFVLSV FLVPRRRLNA AEIYLAHLAA SDLVFALGLP FWAETIRNGF HWPFGAPLCR VVNGVIKANL FISIFLVVAI SRDRYRALVH PVASWRRRRR RHWAQATCVL IWTAGGLLSI PTFLLRSVQV VPELNVSACV LPFPHEAWAF VRTVELNVLG FLLPLAAILF FNYHILAALR GREQLSRTRC GGPRDGKTTA LILTLVAVFL LCWTPYHVCA FLEFLLHVRA IRGCFWEDFT DLGLQYTNFF AFINSCLNPV IYVFWGQLFR TKIWELYHRC LPRKLTAVSS SRRKEIFQIF WRN // ID BKRB2_CAVPO STANDARD; PRT; 372 AA. AC O70526; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 07-MAR-2006, entry version 36. DE B2 bradykinin receptor (BK-2 receptor) (B2R). GN Name=BDKRB2; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Hartley; TISSUE=Lung; RX MEDLINE=98314480; PubMed=9652372; DOI=10.1016/S0014-2999(98)00024-7; RA Farmer S.G., Powell S.J., Wilkins D.E., Graham A.; RT "Cloning, sequencing and functional expression of a guinea pig lung RT bradykinin B2 receptor."; RL Eur. J. Pharmacol. 346:291-298(1998). CC -!- FUNCTION: Receptor for bradykinin. It is associated with G CC proteins that activate a phosphatidylinositol-calcium second CC messenger system (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AJ003243; CAA06025.1; -; mRNA. DR InterPro; IPR001504; B2_bradkn_rcpt. DR InterPro; IPR000496; Brdyknn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF175; B2_bradkn_recept; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00425; BRADYKININR. DR PRINTS; PR00994; BRADYKINNB2R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 372 B2 bradykinin receptor. FT /FTId=PRO_0000069189. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 58 1 (Potential). FT TOPO_DOM 59 67 Cytoplasmic (Potential). FT TRANSMEM 68 92 2 (Potential). FT TOPO_DOM 93 105 Extracellular (Potential). FT TRANSMEM 106 127 3 (Potential). FT TOPO_DOM 128 149 Cytoplasmic (Potential). FT TRANSMEM 150 172 4 (Potential). FT TOPO_DOM 173 195 Extracellular (Potential). FT TRANSMEM 196 222 5 (Potential). FT TOPO_DOM 223 241 Cytoplasmic (Potential). FT TRANSMEM 242 266 6 (Potential). FT TOPO_DOM 267 284 Extracellular (Potential). FT TRANSMEM 285 308 7 (Potential). FT TOPO_DOM 309 364 Cytoplasmic (Potential). FT LIPID 324 324 S-palmitoyl cysteine (By similarity). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 181 181 N-linked (GlcNAc...) (Potential). FT DISULFID 104 185 By similarity. SQ SEQUENCE 372 AA; 42210 MW; 8B736B50887DAE67 CRC64; MFNITSQVSA LNATLAQGNS CLDAEWWSWL NTIQAPFLWV LFVLAVLENI FVLSVFFLHK SSCTVAEIYL GNLAVADLIL AFGLPFWAIT IANNFDWLFG EVLCRMVNTM IQMNMYSSIC FLMLVSIDRY LALVKTMSMG RMRGVRWAKL YSLVIWGCAL LLSSPMLVFR TMKDYRDEGH NVTACLIIYP SLTWQVFTNV LLNLVGFLLP LSIITFCTVQ IMQVLRNNEM QKFKEIQTER RATVLVLAVL LLFVVCWLPF QIGTFLDTLR LLGFLPGCWE HVIDLITQIS SYLAYSNSCL NPLVYVIVGK RFRKKSREVY HGLCRSGGCV SEPAQSENSM GTLRTSISVD RQIHKLQDWA RSSSEGTPPG LL // ID RL3R2_HUMAN STANDARD; PRT; 374 AA. AC Q8TDU9; Q8NGZ8; DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 18-APR-2006, entry version 34. DE Relaxin-3 receptor 2 (Relaxin family peptide receptor 4) (G-protein DE coupled receptor 100) (GPCR142). GN Name=RXFP4; Synonyms=GPR100, RLN3R2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-329, AND FUNCTION. RX PubMed=14522967; DOI=10.1074/jbc.M308996200; RA Liu C., Chen J., Sutton S., Roland B., Kuei C., Farmer N., Sillard R., RA Lovenberg T.W.; RT "Identification of relaxin-3/INSL7 as a ligand for GPCR142."; RL J. Biol. Chem. 278:50765-50770(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=22985413; PubMed=14623098; DOI=10.1016/S0014-5793(03)01196-7; RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., RA Schioeth H.B.; RT "Seven evolutionarily conserved human rhodopsin G protein-coupled RT receptors lacking close relatives."; RL FEBS Lett. 554:381-388(2003). RN [3] RP NUCLEOTIDE SEQUENCE. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=22040266; PubMed=12044878; DOI=10.1016/S0014-5793(02)02775-8; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). RN [5] RP NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY, AND INTERACTIONS WITH RP BRADYKININ AND KALLIDIN. RC TISSUE=Pancreatic carcinoma; RX PubMed=14530218; DOI=10.1038/sj.bjp.0705521; RA Boels K., Schaller H.C.; RT "Identification and characterisation of GPR100 as a novel human G- RT protein-coupled bradykinin receptor."; RL Br. J. Pharmacol. 140:932-938(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Human chromosome 1 international sequencing consortium; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for relaxin-3, as well as bradykinin and CC kallidin. Binding of the ligand inhibit cAMP accumulation. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in a broader range of tissues CC including brain, kidney, testis, thymus, placenta, prostate, CC salivary gland, thyroid and colon. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: Ref.3 sequence differs from that shown due to erroneous CC gene model prediction. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY394502; AAQ92316.1; -; mRNA. DR EMBL; AY288415; AAP72124.1; -; mRNA. DR EMBL; AB065617; BAC05844.1; ALT_SEQ; Genomic_DNA. DR EMBL; AB083593; BAB89306.1; -; Genomic_DNA. DR EMBL; AY170824; AAO17676.1; -; mRNA. DR EMBL; AL355388; CAH72626.1; -; Genomic_DNA. DR UniGene; Hs.449914; -. DR Ensembl; ENSG00000173080; Homo sapiens. DR HGNC; HGNC:14666; RXFP4. DR MIM; 609043; gene. DR LinkHub; Q8TDU9; -. DR InterPro; IPR000248; Angtn2_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 374 Relaxin-3 receptor 2. FT /FTId=PRO_0000070106. FT TOPO_DOM 1 43 Extracellular (Potential). FT TRANSMEM 44 64 1 (Potential). FT TOPO_DOM 65 78 Cytoplasmic (Potential). FT TRANSMEM 79 99 2 (Potential). FT TOPO_DOM 100 116 Extracellular (Potential). FT TRANSMEM 117 137 3 (Potential). FT TOPO_DOM 138 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 4 (Potential). FT TOPO_DOM 176 209 Extracellular (Potential). FT TRANSMEM 210 230 5 (Potential). FT TOPO_DOM 231 249 Cytoplasmic (Potential). FT TRANSMEM 250 270 6 (Potential). FT TOPO_DOM 271 281 Extracellular (Potential). FT TRANSMEM 282 302 7 (Potential). FT TOPO_DOM 303 374 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 114 191 By similarity. FT VARIANT 329 329 L -> S (in dbSNP:2152051). FT /FTId=VAR_021516. SQ SEQUENCE 374 AA; 41141 MW; 1929EA812C0804DA CRC64; MPTLNTSASP PTFFWANASG GSVLSADDAP MPVKFLALRL MVALAYGLVG AIGLLGNLAV LWVLSNCARR APGPPSDTFV FNLALADLGL ALTLPFWAAE SALDFHWPFG GALCKMVLTA TVLNVYASIF LITALSVARY WVVAMAAGPG THLSLFWARI ATLAVWAAAA LVTVPTAVFG VEGEVCGVRL CLLRFPSRYW LGAYQLQRVV LAFMVPLGVI TTSYLLLLAF LQRRQRRRQD SRVVARSVRI LVASFFLCWF PNHVVTLWGV LVKFDLVPWN STFYTIQTYV FPVTTCLAHS NSCLNPVLYC LLRREPRQAL AGTFRDLRLR LWPQGGGWVQ QVALKQVGRR WVASNPRESR PSTLLTNLDR GTPG // ID APJ_XENLA STANDARD; PRT; 353 AA. AC P79960; P70058; DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 04-APR-2006, entry version 37. DE G-protein coupled receptor APJ homolog (Angiotensin receptor-related DE protein) (XAngio1) (Mesenchyme-associated serpentine receptor) (x- DE MSR). GN Name=msr; Synonyms=angio1; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=97109511; PubMed=8951791; DOI=10.1016/0925-4773(96)00585-0; RA Devic E., Paquereau L., Vernier P., Knibiehler B., Audigier Y.; RT "Expression of a new G protein-coupled receptor X-msr is associated RT with an endothelial lineage in Xenopus laevis."; RL Mech. Dev. 59:129-140(1996). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-303. RA Saha M.S., Oakes J.A., Miles R.R.; RT "XAngio1, a novel Xenopus gene, is expressed in vascular precursor RT cells."; RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative receptor for an apelin-like peptide coupled to CC G proteins that inhibit adenylate cyclase activity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: At the gastrula stage, exclusively expressed CC in the mesodermal layer and at the neurula stage in the lateral CC plate mesoderm. Larval expression is observed in the endothelium CC of the primary blood vessels and the forming heart. CC -!- DEVELOPMENTAL STAGE: First expressed at the late blastula stage, CC increases during gastrulation and remains constant between neurula CC and larva stages. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X93045; CAA63612.1; -; mRNA. DR EMBL; U72029; AAB17004.1; -; mRNA. DR UniGene; Xl.23649; -. DR InterPro; IPR000248; Angtn2_rcpt. DR InterPro; IPR003904; APJ_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF176; APJ_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 353 G-protein coupled receptor APJ homolog. FT /FTId=PRO_0000069177. FT TOPO_DOM 1 38 Extracellular (Potential). FT TRANSMEM 39 61 1 (Potential). FT TOPO_DOM 62 72 Cytoplasmic (Potential). FT TRANSMEM 73 95 2 (Potential). FT TOPO_DOM 96 109 Extracellular (Potential). FT TRANSMEM 110 131 3 (Potential). FT TOPO_DOM 132 150 Cytoplasmic (Potential). FT TRANSMEM 151 173 4 (Potential). FT TOPO_DOM 174 206 Extracellular (Potential). FT TRANSMEM 207 229 5 (Potential). FT TOPO_DOM 230 248 Cytoplasmic (Potential). FT TRANSMEM 249 270 6 (Potential). FT TOPO_DOM 271 294 Extracellular (Potential). FT TRANSMEM 295 317 7 (Potential). FT TOPO_DOM 318 353 Cytoplasmic (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT CARBOHYD 181 181 N-linked (GlcNAc...) (Potential). FT CONFLICT 150 150 P -> S (in Ref. 2). SQ SEQUENCE 353 AA; 40303 MW; 1BF757D865057621 CRC64; METEGLSPML YEDDYYYGNE TGLQPCDETD WDFSYSLLPV FYMIVFVLGL SGNGVVIFTV WKSKPKRRSA DTYIGNLALA DLAFVVTLPL WATYTALGFH WPFGSALCKL SSYLVLLNMF ASVFCLTCLS FDRYLAIVHS LSSAKLRSRP SIIVSLAVIW LFSGLLALPS LILRDTRVEG NNTICDLDFS GVSSKENENF WIGGLSILTT VPGFLLPLLL MTIFYCFIGG KVTMHFQNLK KEEQKKKRLL KIIITLVVVF AICWLPFHIL KTIHFLDLMG FLELSCSTQN IIVSLHPYAT CLAYVNSCLN PFLYAFFDLR FRSQCFFFFW FQKSPPRTPQ QHIFQFKCTD SKI // ID C3AR_MOUSE STANDARD; PRT; 477 AA. AC O09047; O35951; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1997, sequence version 1. DT 18-APR-2006, entry version 47. DE C3a anaphylatoxin chemotactic receptor (C3a-R) (C3AR) (Complement DE component 3a receptor 1). GN Name=C3ar1; Synonyms=C3r1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/SvJ, and C57BL/6; TISSUE=Brain; RX MEDLINE=97307604; PubMed=9164946; RA Tornetta M.A., Foley J.J., Sarau H.M., Ames R.S.; RT "The mouse anaphylatoxin C3a receptor: molecular cloning, genomic RT organization, and functional expression."; RL J. Immunol. 158:5277-5282(1997). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/SvJ; RX MEDLINE=98044205; PubMed=9382922; DOI=10.1007/s002510050327; RA Hsu M.H., Ember J.A., Wang M., Prossnitz E.R., Hugli T.E., Ye R.D.; RT "Cloning and functional characterization of the mouse C3a RT anaphylatoxin receptor gene."; RL Immunogenetics 47:64-72(1997). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/SvJ; RX MEDLINE=98357887; PubMed=9694514; DOI=10.1016/S0161-5890(98)00021-2; RA Hollmann T.J., Haviland D.L., Kildsgaard J., Watts K., Wetsel R.A.; RT "Cloning, expression, sequence determination, and chromosome RT localization of the mouse complement C3a anaphylatoxin receptor RT gene."; RL Mol. Immunol. 35:137-148(1998). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary gland; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C3a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Detected in varying levels in all tissues CC examined except the spleen. Especially abundant in heart and lung. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U77461; AAC53204.1; -; Genomic_DNA. DR EMBL; U77460; AAC53203.1; -; mRNA. DR EMBL; U97537; AAB71814.1; -; Genomic_DNA. DR EMBL; AF053757; AAC40193.1; -; Genomic_DNA. DR EMBL; BC003728; AAH03728.1; -; mRNA. DR UniGene; Mm.2408; -. DR Ensembl; ENSMUSG00000040552; Mus musculus. DR MGI; MGI:1097680; C3ar1. DR InterPro; IPR002234; Anphylx_rcpt. DR InterPro; IPR001644; C3A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR01060; C3ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Sensory transduction; Sulfation; Transducer; Transmembrane. FT CHAIN 1 477 C3a anaphylatoxin chemotactic receptor. FT /FTId=PRO_0000069204. FT TOPO_DOM 1 23 Extracellular (Potential). FT TRANSMEM 24 46 1 (Potential). FT TOPO_DOM 47 57 Cytoplasmic (Potential). FT TRANSMEM 58 80 2 (Potential). FT TOPO_DOM 81 96 Extracellular (Potential). FT TRANSMEM 97 118 3 (Potential). FT TOPO_DOM 119 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT TOPO_DOM 161 333 Extracellular (Potential). FT TRANSMEM 334 353 5 (Potential). FT TOPO_DOM 354 370 Cytoplasmic (Potential). FT TRANSMEM 371 393 6 (Potential). FT TOPO_DOM 394 410 Extracellular (Potential). FT TRANSMEM 411 431 7 (Potential). FT TOPO_DOM 432 477 Cytoplasmic (Potential). FT MOD_RES 174 174 Sulfotyrosine (By similarity). FT MOD_RES 184 184 Sulfotyrosine (By similarity). FT MOD_RES 312 312 Sulfotyrosine (By similarity). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 168 168 N-linked (GlcNAc...) (Potential). FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential). FT CARBOHYD 201 201 N-linked (GlcNAc...) (Potential). FT DISULFID 95 172 By similarity. FT CONFLICT 173 173 R -> K (in Ref. 2). FT CONFLICT 195 195 E -> K (in Ref. 2). FT CONFLICT 243 243 D -> N (in Ref. 2). FT CONFLICT 276 276 D -> N (in Ref. 2). FT CONFLICT 380 382 FIC -> LS (in Ref. 2). FT CONFLICT 391 391 V -> I (in Ref. 2). FT CONFLICT 460 460 N -> S (in Ref. 2). SQ SEQUENCE 477 AA; 53576 MW; 9873F464A1520984 CRC64; MESFDADTNS TDLHSRPLFQ PQDIASMVIL GLTCLLGLLG NGLVLWVAGV KMKTTVNTVW FLHLTLADFL CCLSLPFSLA HLILQGHWPY GLFLCKLIPS IIILNMFASV FLLTAISLDR CLIVHKPIWC QNHRNVRTAF AICGCVWVVA FVMCVPVFVY RDLFIMDNRS ICRYNFDSSR SYDYWDYVYK LSLPESNSTD NSTAQLTGHM NDRSAPSSVQ ARDYFWTVTT ALQSQPFLTS PEDSFSLDSA NQQPHYGGKP PNVLTAAVPS GFPVEDRKSN TLNADAFLSA HTELFPTASS GHLYPYDFQG DYVDQFTYDN HVPTPLMAIT ITRLVVGFLV PFFIMVICYS LIVFRMRKTN FTKSRNKTFR VAVAVVTVFF ICWTPYHLVG VLLLITDPES SLGEAVMSWD HMSIALASAN SCFNPFLYAL LGKDFRKKAR QSIKGILEAA FSEELTHSTN CTQDKASSKR NNMSTDV // ID FPRL1_HUMAN STANDARD; PRT; 351 AA. AC P25090; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 2. DT 18-APR-2006, entry version 59. DE FMLP-related receptor I (FMLP-R-I) (Lipoxin A4 receptor) (LXA4 DE receptor) (Formyl peptide receptor-like 1) (RFP) (HM63). GN Name=FPRL1; Synonyms=FPR2, FPRH1, LXA4R; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92307681; PubMed=1612600; RA Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.; RT "Mapping of genes for the human C5a receptor (C5AR), human FMLP RT receptor (FPR), and two FMLP receptor homologue orphan receptors RT (FPRH1, FPRH2) to chromosome 19."; RL Genomics 13:437-440(1992). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Bone marrow; RX MEDLINE=92380523; PubMed=1511907; DOI=10.1016/0378-1119(92)90208-7; RA Perez H.D., Holmes R., Kelly E., McClary J., Andrews W.H.; RT "Cloning of a cDNA encoding a receptor related to the formyl peptide RT receptor of human neutrophils."; RL Gene 118:303-304(1992). RN [3] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Granulocyte; RX MEDLINE=92246937; PubMed=1374236; RA Ye R.D., Cavanagh S.L., Quehenberger O., Prossnitz E.R., RA Cochrane C.G.; RT "Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide RT receptor."; RL Biochem. Biophys. Res. Commun. 184:582-589(1992). RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92218423; PubMed=1373134; RA Murphy P.M., Ozcelik T., Kenney R.T., Tiffany H.L., McDermott D., RA Francke U.; RT "A structural homologue of the N-formyl peptide receptor. RT Characterization and chromosome mapping of a peptide chemoattractant RT receptor family."; RL J. Biol. Chem. 267:7637-7643(1992). RN [5] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Monocyte; RX MEDLINE=94092629; PubMed=7505609; RA Nomura H., Nielsen B.W., Matsushima K.; RT "Molecular cloning of cDNAs encoding a LD78 receptor and putative RT leukocyte chemotactic peptide receptors."; RL Int. Immunol. 5:1239-1249(1993). RN [6] RP NUCLEOTIDE SEQUENCE. RA Maddox J.F., Hachicha M., Takano T., Petasis N.A., Fokin V.V., RA Serhan C.N.; RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=98215774; PubMed=9547339; DOI=10.1084/jem.187.8.1285; RA Gronert K., Gewirtz A., Madara J.L., Serhan C.N.; RT "Identification of a human enterocyte lipoxin A4 receptor that is RT regulated by interleukin (IL)-13 and interferon gamma and inhibits RT tumor necrosis factor alpha-induced IL-8 release."; RL J. Exp. Med. 187:1285-1294(1998). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Blood; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [11] RP TISSUE SPECIFICITY. RX MEDLINE=97296322; PubMed=9151906; DOI=10.1084/jem.185.9.1693; RA Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., RA Serhan C.N.; RT "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues RT are potent inhibitors of acute inflammation: evidence for anti- RT inflammatory receptors."; RL J. Exp. Med. 185:1693-1704(1997). CC -!- FUNCTION: Low affinity receptor to N-formyl-methionyl peptides, CC which are powerful neutrophils chemotactic factors. Binding of CC FMLP to the receptor causes activation of neutrophils. This CC response is mediated via a G-protein that activates a CC phosphatidylinositol-calcium second messenger system. The CC activation of LXA4R could result in an anti-inflammatory outcome CC counteracting the actions of proinflammatory signals such as LTB4 CC (leukotriene B4). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed abundantly in the lung and CC neutrophils. Also found in the spleen and testis. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M76672; AAA58481.1; -; mRNA. DR EMBL; X63819; CAA45319.1; -; mRNA. DR EMBL; M88107; AAA60070.1; -; mRNA. DR EMBL; M84562; AAA52473.1; -; mRNA. DR EMBL; D10922; BAA01720.1; -; mRNA. DR EMBL; U81501; AAB51133.1; -; mRNA. DR EMBL; AF054013; AAC13684.1; -; mRNA. DR EMBL; AY225226; AAO67711.1; -; Genomic_DNA. DR EMBL; AC018755; AAF87844.1; -; Genomic_DNA. DR EMBL; BC029125; AAH29125.1; -; mRNA. DR EMBL; BC071722; AAH71722.1; -; mRNA. DR PIR; B42009; B42009. DR UniGene; Hs.99855; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSG00000171049; Homo sapiens. DR H-InvDB; HIX0019402; -. DR HGNC; HGNC:3827; FPRL1. DR MIM; 136538; gene. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0004982; F:N-formyl peptide receptor activity; TAS. DR GO; GO:0007155; P:cell adhesion; TAS. DR GO; GO:0006928; P:cell motility; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Sensory transduction; Transducer; Transmembrane. FT CHAIN 1 351 FMLP-related receptor I. FT /FTId=PRO_0000069451. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 50 1 (Potential). FT TOPO_DOM 51 61 Cytoplasmic (Potential). FT TRANSMEM 62 83 2 (Potential). FT TOPO_DOM 84 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT TOPO_DOM 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 162 4 (Potential). FT TOPO_DOM 163 205 Extracellular (Potential). FT TRANSMEM 206 226 5 (Potential). FT TOPO_DOM 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 266 6 (Potential). FT TOPO_DOM 267 286 Extracellular (Potential). FT TRANSMEM 287 306 7 (Potential). FT TOPO_DOM 307 351 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT DISULFID 98 176 Potential. FT CONFLICT 339 339 S -> C (in Ref. 1). SQ SEQUENCE 351 AA; 38964 MW; DC6A1D77AFC0D780 CRC64; METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV AGFRMTRTVT TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL IHIVVDINLF GSVFLIGFIA LDRCICVLHP VWAQNHRTVS LAMKVIVGPW ILALVLTLPV FLFLTTVTIP NGDTYCTFNF ASWGGTPEER LKVAITMLTA RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL RVLTAVVASF FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA M // ID FPRL2_HUMAN STANDARD; PRT; 353 AA. AC P25089; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 07-NOV-2003, sequence version 2. DT 18-APR-2006, entry version 51. DE FMLP-related receptor II (FMLP-R-II) (Formylpeptide receptor-like 2). GN Name=FPRL2; Synonyms=FPRH1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92307681; PubMed=1612600; RA Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.; RT "Mapping of genes for the human C5a receptor (C5AR), human FMLP RT receptor (FPR), and two FMLP receptor homologue orphan receptors RT (FPRH1, FPRH2) to chromosome 19."; RL Genomics 13:437-440(1992). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94256976; PubMed=8198572; RA Durstin M., Gao J.-L., Tiffany H.L., McDermott D., Murphy P.M.; RT "Differential expression of members of the N-formylpeptide receptor RT gene cluster in human phagocytes."; RL Biochem. Biophys. Res. Commun. 201:174-179(1994). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Low affinity receptor to N-formyl-methionyl peptides, CC which are powerful neutrophils chemotactic factors. Binding of CC FMLP to the receptor causes activation of neutrophils. This CC response is mediated via a G-protein that activates a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M76673; AAA58482.1; -; mRNA. DR EMBL; L14061; AAA52474.1; -; Genomic_DNA. DR EMBL; AY262690; AAP20654.1; -; Genomic_DNA. DR EMBL; BC059388; AAH59388.1; -; mRNA. DR EMBL; BC069070; AAH69070.1; -; mRNA. DR EMBL; BC069593; AAH69593.1; -; mRNA. DR EMBL; BC069812; AAH69812.1; -; mRNA. DR PIR; C42009; C42009. DR UniGene; Hs.445466; -. DR Ensembl; ENSG00000187474; Homo sapiens. DR HGNC; HGNC:3828; FPRL2. DR MIM; 136539; gene. DR LinkHub; P25089; -. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004982; F:N-formyl peptide receptor activity; TAS. DR GO; GO:0006928; P:cell motility; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Sensory transduction; Transducer; Transmembrane. FT CHAIN 1 353 FMLP-related receptor II. FT /FTId=PRO_0000069457. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 50 1 (Potential). FT TOPO_DOM 51 61 Cytoplasmic (Potential). FT TRANSMEM 62 83 2 (Potential). FT TOPO_DOM 84 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT TOPO_DOM 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 162 4 (Potential). FT TOPO_DOM 163 205 Extracellular (Potential). FT TRANSMEM 206 226 5 (Potential). FT TOPO_DOM 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 266 6 (Potential). FT TOPO_DOM 267 286 Extracellular (Potential). FT TRANSMEM 287 306 7 (Potential). FT TOPO_DOM 307 353 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT DISULFID 98 176 Potential. FT CONFLICT 94 94 G -> A (in Ref. 1). FT CONFLICT 211 211 S -> T (in Ref. 1). FT CONFLICT 338 338 D -> H (in Ref. 1). SQ SEQUENCE 353 AA; 39965 MW; FFB7150B6A833F4C CRC64; METNFSIPLN ETEEVLPEPA GHTVLWIFSL LVHGVTFVFG VLGNGLVIWV AGFRMTRTVN TICYLNLALA DFSFSAILPF RMVSVAMREK WPFGSFLCKL VHVMIDINLF VSVYLITIIA LDRCICVLHP AWAQNHRTMS LAKRVMTGLW IFTIVLTLPN FIFWTTISTT NGDTYCIFNF AFWGDTAVER LNVFITMAKV FLILHFIIGF SVPMSIITVC YGIIAAKIHR NHMIKSSRPL RVFAAVVASF FICWFPYELI GILMAVWLKE MLLNGKYKII LVLINPTSSL AFFNSCLNPI LYVFMGRNFQ ERLIRSLPTS LERALTEVPD SAQTSNTDTT SASPPEETEL QAM // ID GPR32_HUMAN STANDARD; PRT; 356 AA. AC O75388; Q6NWS5; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 18-APR-2006, entry version 43. DE Probable G-protein coupled receptor 32. GN Name=GPR32; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=98317543; PubMed=9653656; DOI=10.1006/geno.1998.5297; RA Marchese A., Nguyen T., Malik P., Xu S., Cheng R., Xie Z., RA Heng H.H.Q., George S.R., Kolakowski L.F. Jr., O'Dowd B.F.; RT "Cloning genes encoding receptors related to chemoattractant RT receptors."; RL Genomics 50:281-286(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF045764; AAC39801.1; -; Genomic_DNA. DR EMBL; BC067453; AAH67453.1; -; mRNA. DR EMBL; BC067454; AAH67454.1; -; mRNA. DR UniGene; Hs.515555; -. DR Ensembl; ENSG00000142511; Homo sapiens. DR HGNC; HGNC:4487; GPR32. DR MIM; 603195; gene. DR LinkHub; O75388; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 356 Probable G-protein coupled receptor 32. FT /FTId=PRO_0000069552. FT TOPO_DOM 1 44 Extracellular (Potential). FT TRANSMEM 45 67 1 (Potential). FT TOPO_DOM 68 78 Cytoplasmic (Potential). FT TRANSMEM 79 100 2 (Potential). FT TOPO_DOM 101 116 Extracellular (Potential). FT TRANSMEM 117 137 3 (Potential). FT TOPO_DOM 138 156 Cytoplasmic (Potential). FT TRANSMEM 157 178 4 (Potential). FT TOPO_DOM 179 220 Extracellular (Potential). FT TRANSMEM 221 241 5 (Potential). FT TOPO_DOM 242 257 Cytoplasmic (Potential). FT TRANSMEM 258 280 6 (Potential). FT TOPO_DOM 281 300 Extracellular (Potential). FT TRANSMEM 301 320 7 (Potential). FT TOPO_DOM 321 356 Cytoplasmic (Potential). FT CARBOHYD 30 30 N-linked (GlcNAc...) (Potential). FT CARBOHYD 199 199 N-linked (GlcNAc...) (Potential). FT DISULFID 114 191 Potential. FT VARIANT 327 327 F -> L (in dbSNP:1864011). FT /FTId=VAR_011860. FT CONFLICT 167 167 L -> P (in Ref. 2; AAH67453). FT CONFLICT 186 186 N -> D (in Ref. 2; AAH67453). SQ SEQUENCE 356 AA; 40087 MW; 0E00DCF4BD7F4C3A CRC64; MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL SASIVVGVLG NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY YIVSRQWLLG EWACKLYITF VFLSYFASNC LLVFISVDRC ISVLYPVWAL NHRTVQRASW LAFGVWLLAA ALCSAHLKFR TTRKWNGCTH CYLAFNSDNE TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR AKLLREGWVH ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR GNAPRE // ID GPR33_MOUSE STANDARD; PRT; 339 AA. AC O88416; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 18-APR-2006, entry version 42. DE Probable G-protein coupled receptor 33. GN Name=Gpr33; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98317543; PubMed=9653656; DOI=10.1006/geno.1998.5297; RA Marchese A., Nguyen T., Malik P., Xu S., Cheng R., Xie Z., RA Heng H.H.Q., George S.R., Kolakowski L.F. Jr., O'Dowd B.F.; RT "Cloning genes encoding receptors related to chemoattractant RT receptors."; RL Genomics 50:281-286(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Thymus; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [3] RP TISSUE SPECIFICITY. RX PubMed=15987686; DOI=10.1074/jbc.M503586200; RA Roempler H., Schulz A., Pitra C., Coop G., Przeworski M., Paeaebo S., RA Schoeneberg T.; RT "The rise and fall of the chemoattractant receptor GPR33."; RL J. Biol. Chem. 280:31068-31075(2005). CC -!- FUNCTION: Orphan receptor; could be a chemoattractant receptor. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed predominantly in lung, spleen and CC testis. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF045766; AAC40152.1; -; mRNA. DR EMBL; BC064084; AAH64084.1; -; mRNA. DR UniGene; Mm.12890; -. DR Ensembl; ENSMUSG00000035148; Mus musculus. DR MGI; MGI:1277106; Gpr33. DR LinkHub; O88416; -. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 339 Probable G-protein coupled receptor 33. FT /FTId=PRO_0000069554. FT TOPO_DOM 1 30 Extracellular (Potential). FT TRANSMEM 31 53 1 (Potential). FT TOPO_DOM 54 64 Cytoplasmic (Potential). FT TRANSMEM 65 86 2 (Potential). FT TOPO_DOM 87 103 Extracellular (Potential). FT TRANSMEM 104 124 3 (Potential). FT TOPO_DOM 125 143 Cytoplasmic (Potential). FT TRANSMEM 144 165 4 (Potential). FT TOPO_DOM 166 209 Extracellular (Potential). FT TRANSMEM 210 230 5 (Potential). FT TOPO_DOM 231 246 Cytoplasmic (Potential). FT TRANSMEM 247 268 6 (Potential). FT TOPO_DOM 269 283 Extracellular (Potential). FT TRANSMEM 284 303 7 (Potential). FT TOPO_DOM 304 339 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT DISULFID 101 179 Potential. SQ SEQUENCE 339 AA; 38446 MW; CCA468A38B55A1FA CRC64; MDLINSSTHV INVSTSLTNS TGVPTPAPKT IIAASLFMAF IIGVISNGLY LWMLQFKMQR TVNTLLFFHL ILSYFISTLI LPFMATSFLQ DNHWVFGSVL CKAFNSTLSV SMFASVFFLS AISVARYYLI LHPVWSQQHR TPHWASRIAL QIWISATILS IPYLVFRTTH DDHKGRIKCQ NNYIVSTDWE SKEHQTLGQW IHAACFVGRF LLGFLLPFLV IIFCYKRVAT KMKEKGLFKS SKPFKVMVTA VISFFVCWMP YHVHSGLVLT KSQPLPLHLT LGLAVVTISF NTVVSPVLYL FTGENFKVFK KSILALFNST FSDISSTERT QTLNSETEI // ID C5AR_GORGO STANDARD; PRT; 340 AA. AC P79175; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 18-APR-2006, entry version 39. DE C5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (CD88 antigen) DE (Fragment). GN Name=C5AR1; Synonyms=C5AR, C5R1; OS Gorilla gorilla gorilla (Lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=96421539; PubMed=8824156; DOI=10.1007/s002510050151; RA Alvarez V., Coto E., Sehen F., Gouzalek-Koces S., Lopez-Larrea C.; RT "Molecular evolution of the N-formyl peptide and C5a receptors in non- RT human primates."; RL Immunogenetics 44:446-452(1996). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C5a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Sulfation plays a critical role in the association of C5aR CC with C5a, but no significant role in the ability of the receptor CC to transduce a signal and mobilize calcium in response to a small CC peptide agonist (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X97733; CAA66317.1; -; Genomic_DNA. DR InterPro; IPR002234; Anphylx_rcpt. DR InterPro; IPR001274; C5A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Membrane; Phosphorylation; KW Receptor; Sensory transduction; Sulfation; Transducer; Transmembrane. FT CHAIN <1 >340 C5a anaphylatoxin chemotactic receptor. FT /FTId=PRO_0000069208. FT TOPO_DOM <1 30 Extracellular (Potential). FT TRANSMEM 31 53 1 (Potential). FT TOPO_DOM 54 64 Cytoplasmic (Potential). FT TRANSMEM 65 87 2 (Potential). FT TOPO_DOM 88 103 Extracellular (Potential). FT TRANSMEM 104 125 3 (Potential). FT TOPO_DOM 126 146 Cytoplasmic (Potential). FT TRANSMEM 147 167 4 (Potential). FT TOPO_DOM 168 193 Extracellular (Potential). FT TRANSMEM 194 219 5 (Potential). FT TOPO_DOM 220 235 Cytoplasmic (Potential). FT TRANSMEM 236 258 6 (Potential). FT TOPO_DOM 259 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT TOPO_DOM 297 >340 Cytoplasmic (Potential). FT MOD_RES 4 4 Sulfotyrosine (By similarity). FT MOD_RES 7 7 Sulfotyrosine (By similarity). FT MOD_RES 307 307 Phosphoserine (By similarity). FT MOD_RES 310 310 Phosphoserine (By similarity). FT MOD_RES 320 320 Phosphoserine (By similarity). FT MOD_RES 325 325 Phosphoserine (By similarity). FT MOD_RES 327 327 Phosphoserine (By similarity). FT MOD_RES 331 331 Phosphoserine (By similarity). FT DISULFID 102 181 By similarity. FT NON_TER 1 1 FT NON_TER 340 340 SQ SEQUENCE 340 AA; 38235 MW; 214CFCE78A47B304 CRC64; TPDYGHYDDK DTLDPNTPVD KTSNTLRVPD ILALVIFAVV FLVGVLGNAM VVWVTAFEAK RTINAIWFLN LAVADFLSCL ALPILFTSIV QHHHWPFGGA ACRILPSLIL LNMYASILLL ATISADRFLL VFKPIWCQNF RGAGLAWIAC AVAWGLALLL TIPSFLYRVV REEYFPPKVL CGVDYSHDKR RERAVAIVRL VLGFLWPLLT LTICYTFILL RTWSRRATRS TKTLKVVVAV VASFFIFWLP YQVTGIMMSF LEPSSPTFLL LNKLDSLCVS FAYINCCINP IIYVVAGQGF QGRLRKSLPS LLRNVLTEES VVRESKSFTR STVDTMAQKT // ID C5AR_CAVPO STANDARD; PRT; 345 AA. AC O70129; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 07-MAR-2006, entry version 36. DE C5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (CD88 antigen). GN Name=C5AR1; Synonyms=C5R1; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Hartley; RX MEDLINE=98236152; PubMed=9576615; DOI=10.1093/intimm/10.3.275; RA Fukuoka Y., Ember J.A., Yasui A., Hugli T.E.; RT "Cloning and characterization of the guinea pig C5a anaphylatoxin RT receptor: interspecies diversity among the C5a receptors."; RL Int. Immunol. 10:275-283(1998). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C5a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Sulfation plays a critical role in the association of C5aR CC with C5a, but no significant role in the ability of the receptor CC to transduce a signal and mobilize calcium in response to a small CC peptide agonist (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U86103; AAC40074.1; -; mRNA. DR InterPro; IPR002234; Anphylx_rcpt. DR InterPro; IPR001274; C5A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Receptor; Sensory transduction; Sulfation; KW Transducer; Transmembrane. FT CHAIN 1 345 C5a anaphylatoxin chemotactic receptor. FT /FTId=PRO_0000069207. FT TOPO_DOM 1 32 Extracellular (Potential). FT TRANSMEM 33 55 1 (Potential). FT TOPO_DOM 56 66 Cytoplasmic (Potential). FT TRANSMEM 67 89 2 (Potential). FT TOPO_DOM 90 105 Extracellular (Potential). FT TRANSMEM 106 127 3 (Potential). FT TOPO_DOM 128 148 Cytoplasmic (Potential). FT TRANSMEM 149 169 4 (Potential). FT TOPO_DOM 170 195 Extracellular (Potential). FT TRANSMEM 196 221 5 (Potential). FT TOPO_DOM 222 237 Cytoplasmic (Potential). FT TRANSMEM 238 260 6 (Potential). FT TOPO_DOM 261 277 Extracellular (Potential). FT TRANSMEM 278 298 7 (Potential). FT TOPO_DOM 299 345 Cytoplasmic (Potential). FT MOD_RES 7 7 Sulfotyrosine (By similarity). FT MOD_RES 9 9 Sulfotyrosine (By similarity). FT MOD_RES 11 11 Sulfotyrosine (By similarity). FT MOD_RES 309 309 Phosphoserine (By similarity). FT MOD_RES 312 312 Phosphoserine (By similarity). FT MOD_RES 322 322 Phosphoserine (By similarity). FT MOD_RES 329 329 Phosphoserine (By similarity). FT MOD_RES 333 333 Phosphoserine (By similarity). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT DISULFID 104 183 By similarity. SQ SEQUENCE 345 AA; 38592 MW; BE40459F1450404A CRC64; MMVTVSYDYD YNSTFLPDGF VDNYVERLSF GDLVAVVIMV VVFLVGVPGN ALVVWVTACE ARRHINAIWF LNLAAADLLS CLALPILLVS TVHLNHWYFG DTACKVLPSL ILLNMYTSIL LLATISADRL LLVLSPIWCQ RFRGGCLAWT ACGLAWVLAL LLSSPSFLYR RTHNEHFSFK VYCVTDYGRD ISKERAVALV RLLVGFIVPL ITLTACYTFL LLRTWSRKAT RSAKTVKVVV AVVSSFFVFW LPYQVTGILL AWHSPNSATY RNTKALDAVC VAFAYINCCI NPIIYVVAGH GFQGRLLKSL PSVLRNVLTE ESLDKRHQSF ARSTVDTMPQ KSESV // ID C5ARL_HUMAN STANDARD; PRT; 337 AA. AC Q9P296; DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 02-MAY-2006, entry version 40. DE C5a anaphylatoxin chemotactic receptor C5L2 (G-protein coupled DE receptor 77). GN Name=GPR77; Synonyms=C5L2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta; RA Ohno M., Hirata T., Enomoto M., Araki T., Sato K., Ishimaru H., RA Takahashi T.A.; RT "A putative chemoattractant receptor, C5L2 is expressed in granulocyte RT and immature dendritic cells, but mature dendritc cells."; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RX PubMed=11165367; DOI=10.1016/S0169-328X(00)00242-4; RA Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., RA Lynch K.R., O'Dowd B.F.; RT "Identification of four novel human G protein-coupled receptors RT expressed in the brain."; RL Brain Res. Mol. Brain Res. 86:13-22(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP FUNCTION. RC TISSUE=Brain; RX MEDLINE=21850712; PubMed=11773063; DOI=10.1074/jbc.C100714200; RA Cain S.A., Monk P.N.; RT "The orphan receptor C5L2 has high affinity binding sites for RT complement fragments C5a and C5a des Arg(74)."; RL J. Biol. Chem. 277:7165-7169(2002). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C5a, C4a and C3a and their desarginated derivatives. CC Couples weakly to Gi-mediated signaling pathways. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Frontal cortex, hippocampus, hypothalamus, CC pons and liver. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB038237; BAA95414.1; -; mRNA. DR EMBL; AF317655; AAK12640.1; -; Genomic_DNA. DR EMBL; AY268430; AAP23197.1; -; Genomic_DNA. DR EMBL; BC067478; AAH67478.1; -; mRNA. DR UniGene; Hs.534412; -. DR Ensembl; ENSG00000134830; Homo sapiens. DR HGNC; HGNC:4527; GPR77. DR MIM; 609949; gene. DR GO; GO:0016526; F:G-protein coupled receptor activity, unknow...; NAS. DR InterPro; IPR001274; C5A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 337 C5a anaphylatoxin chemotactic receptor FT C5L2. FT /FTId=PRO_0000069216. FT TOPO_DOM 1 38 Extracellular (Potential). FT TRANSMEM 39 61 1 (Potential). FT TOPO_DOM 62 72 Cytoplasmic (Potential). FT TRANSMEM 73 95 2 (Potential). FT TOPO_DOM 96 114 Extracellular (Potential). FT TRANSMEM 115 137 3 (Potential). FT TOPO_DOM 138 149 Cytoplasmic (Potential). FT TRANSMEM 150 172 4 (Potential). FT TOPO_DOM 173 202 Extracellular (Potential). FT TRANSMEM 203 225 5 (Potential). FT TOPO_DOM 226 237 Cytoplasmic (Potential). FT TRANSMEM 238 260 6 (Potential). FT TOPO_DOM 261 274 Extracellular (Potential). FT TRANSMEM 275 294 7 (Potential). FT TOPO_DOM 295 337 Cytoplasmic (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 107 186 By similarity. SQ SEQUENCE 337 AA; 36080 MW; 53AF41B129FE8FE6 CRC64; MGNDSVSYEY GDYSDLSDRP VDCLDGACLA IDPLRVAPLP LYAAIFLVGV PGNAMVAWVA GKVARRRVGA TWLLHLAVAD LLCCLSLPIL AVPIARGGHW PYGAVGCRAL PSIILLTMYA SVLLLAALSA DLCFLALGPA WWSTVQRACG VQVACGAAWT LALLLTVPSA IYRRLHQEHF PARLQCVVDY GGSSSTENAV TAIRFLFGFL GPLVAVASCH SALLCWAARR CRPLGTAIVV GFFVCWAPYH LLGLVLTVAA PNSALLARAL RAEPLIVGLA LAHSCLNPML FLYFGRAQLR RSLPAACHWA LRESQGQDES VDSKKSTSHD LVSEMEV // ID PAR1_MOUSE STANDARD; PRT; 430 AA. AC P30558; P97507; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 2. DT 02-MAY-2006, entry version 61. DE Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor). GN Name=F2r; Synonyms=Cf2r, Par1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RA Coughlin S.R.; RT "Cloning of cDNA for the mouse thrombin receptor."; RL Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129; RX MEDLINE=96379236; PubMed=8784787; RA Kahn M.L., Ishii K., Kuo W.L., Piper M., Connolly A.J., Shi Y.P., RA Wu R., Lin C.C., Coughlin S.R.; RT "Conserved structure and adjacent location of the thrombin receptor RT and protease-activated receptor 2 genes define a protease-activated RT receptor gene cluster."; RL Mol. Med. 2:349-357(1996). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Heart; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary gland; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP NUCLEOTIDE SEQUENCE OF 1-74. RC STRAIN=129/Sv; RX MEDLINE=96327649; PubMed=8678993; DOI=10.1007/s003359900189; RA Xue J., Jenkins N.A., Gilbert D.J., Copeland N.G., Sadler J.E.; RT "Structure and localization of the thrombin receptor gene on mouse RT chromosome 13."; RL Mamm. Genome 7:625-626(1996). CC -!- FUNCTION: High affinity receptor for activated thrombin coupled to CC G proteins that stimulate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: A proteolytic cleavage generates a new N-terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L03529; AAA40438.1; -; mRNA. DR EMBL; U36757; AAB38308.1; -; Genomic_DNA. DR EMBL; U36756; AAB38308.1; JOINED; Genomic_DNA. DR EMBL; AK085990; BAC39587.1; -; mRNA. DR EMBL; BC031516; AAH31516.1; -; mRNA. DR EMBL; U55076; AAB00198.1; -; Genomic_DNA. DR EMBL; U55075; AAB00198.1; JOINED; Genomic_DNA. DR UniGene; Mm.24816; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSMUSG00000048376; Mus musculus. DR MGI; MGI:101802; F2r. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003912; Protea_act_rcpt. DR InterPro; IPR000935; Thrmbn_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01428; PROTEASEAR. DR PRINTS; PR00908; THROMBINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Blood coagulation; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Signal; Transducer; Transmembrane. FT SIGNAL 1 21 Potential. FT PROPEP 22 41 Removed for receptor activation (By FT similarity). FT /FTId=PRO_0000012742. FT CHAIN 42 430 Proteinase-activated receptor 1. FT /FTId=PRO_0000012743. FT TOPO_DOM 42 107 Extracellular (Potential). FT TRANSMEM 108 133 1 (Potential). FT TOPO_DOM 134 142 Cytoplasmic (Potential). FT TRANSMEM 143 162 2 (Potential). FT TOPO_DOM 163 181 Extracellular (Potential). FT TRANSMEM 182 203 3 (Potential). FT TOPO_DOM 204 223 Cytoplasmic (Potential). FT TRANSMEM 224 244 4 (Potential). FT TOPO_DOM 245 273 Extracellular (Potential). FT TRANSMEM 274 293 5 (Potential). FT TOPO_DOM 294 316 Cytoplasmic (Potential). FT TRANSMEM 317 339 6 (Potential). FT TOPO_DOM 340 354 Extracellular (Potential). FT TRANSMEM 355 379 7 (Potential). FT TOPO_DOM 380 430 Cytoplasmic (Potential). FT COMPBIAS 60 65 Asp/Glu-rich (acidic). FT COMPBIAS 88 91 Poly-Pro. FT SITE 41 42 Cleavage (by thrombin) (By similarity). FT CARBOHYD 67 67 N-linked (GlcNAc...) (Potential). FT CARBOHYD 80 80 N-linked (GlcNAc...) (Potential). FT CARBOHYD 255 255 N-linked (GlcNAc...) (Potential). FT DISULFID 180 259 By similarity. FT CONFLICT 162 162 F -> S (in Ref. 1). FT CONFLICT 189 189 G -> Y (in Ref. 1). FT CONFLICT 223 223 R -> G (in Ref. 1). FT CONFLICT 262 262 V -> L (in Ref. 1). FT CONFLICT 365 365 S -> T (in Ref. 1). SQ SEQUENCE 430 AA; 47790 MW; 395FD64FAE52C9BF CRC64; MGPRRLLIVA LGLSLCGPLL SSRVPMSQPE SERTDATVNP RSFFLRNPSE NTFELVPLGD EEEEEKNESV LLEGRAVYLN ISLPPHTPPP PFISEDASGY LTSPWLTLFM PSVYTIVFIV SLPLNVLAIA VFVLRMKVKK PAVVYMLHLA MADVLFVSVL PFKISYYFSG TDWQFGSGMC RFATAAFYGN MYASIMLMTV ISIDRFLAVV YPIQSLSWRT LGRANFTCVV IWVMAIMGVV PLLLKEQTTR VPGLNITTCH DVLSENLMQG FYSYYFSAFS AIFFLVPLIV STVCYTSIIR CLSSSAVANR SKKSRALFLS AAVFCIFIVC FGPTNVLLIV HYLFLSDSPG TEAAYFAYLL CVCVSSVSCC IDPLIYYYAS SECQRHLYSI LCCKESSDPN SCNSTGQLMP SKMDTCSSHL NNSIYKKLLA // ID PAR3_MOUSE STANDARD; PRT; 369 AA. AC O08675; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1997, sequence version 1. DT 18-APR-2006, entry version 49. DE Proteinase-activated receptor 3 precursor (PAR-3) (Thrombin receptor- DE like 2) (Coagulation factor II receptor-like 2). GN Name=F2rl2; Synonyms=Par3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/6; RX MEDLINE=97242411; PubMed=9087410; DOI=10.1038/386502a0; RA Ishihara H., Connolly A.J., Zeng D., Kahn M.L., Zheng Y.-W., RA Timmons C., Tram T., Coughlin S.R.; RT "Protease-activated receptor 3 is a second thrombin receptor in RT humans."; RL Nature 386:502-506(1997). CC -!- FUNCTION: High affinity receptor for activated thrombin coupled to CC G proteins that stimulate phosphoinositide hydrolysis. May play a CC role in platelets activation. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: A proteolytic cleavage generates a new N-terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U92972; AAC53137.1; -; mRNA. DR UniGene; Mm.1612; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSMUSG00000021675; Mus musculus. DR MGI; MGI:1298208; F2rl2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003943; Prot_act_rcpt_3. DR InterPro; IPR003912; Protea_act_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01428; PROTEASEAR. DR PRINTS; PR01429; PROTEASEAR3. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Blood coagulation; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Signal; Transducer; Transmembrane. FT SIGNAL 1 19 Potential. FT PROPEP 20 37 Removed for receptor activation (By FT similarity). FT /FTId=PRO_0000012758. FT CHAIN 38 369 Proteinase-activated receptor 3. FT /FTId=PRO_0000012759. FT TOPO_DOM 38 93 Extracellular (Potential). FT TRANSMEM 94 119 1 (Potential). FT TOPO_DOM 120 127 Cytoplasmic (Potential). FT TRANSMEM 128 147 2 (Potential). FT TOPO_DOM 148 166 Extracellular (Potential). FT TRANSMEM 167 188 3 (Potential). FT TOPO_DOM 189 205 Cytoplasmic (Potential). FT TRANSMEM 206 229 4 (Potential). FT TOPO_DOM 230 259 Extracellular (Potential). FT TRANSMEM 260 279 5 (Potential). FT TOPO_DOM 280 296 Cytoplasmic (Potential). FT TRANSMEM 297 321 6 (Potential). FT TOPO_DOM 322 335 Extracellular (Potential). FT TRANSMEM 336 360 7 (Potential). FT TOPO_DOM 361 369 Cytoplasmic (Potential). FT SITE 37 38 Cleavage (by thrombin) (By similarity). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 81 81 N-linked (GlcNAc...) (Potential). FT DISULFID 165 244 By similarity. SQ SEQUENCE 369 AA; 41708 MW; F4166BF766D073DB CRC64; MKILILVAAG LLFLPVTVCQ SGINVSDNSA KPTLTIKSFN GGPQNTFEEF PLSDIEGWTG ATTTIKAECP EDSISTLHVN NATIGYLRSS LSTQVIPAIY ILLFVVGVPS NIVTLWKLSL RTKSISLVIF HTNLAIADLL FCVTLPFKIA YHLNGNNWVF GEVMCRITTV VFYGNMYCAI LILTCMGINR YLATAHPFTY QKLPKRSFSL LMCGIVWVMV FLYMLPFVIL KQEYHLVHSE ITTCHDVVDA CESPSSFRFY YFVSLAFFGF LIPFVIIIFC YTTLIHKLKS KDRIWLGYIK AVLLILVIFT ICFAPTNIIL VIHHANYYYH NTDSLYFMYL IALCLGSLNS CLDPFLYFVM SKVVDQLNP // ID PAR4_MOUSE STANDARD; PRT; 396 AA. AC O88634; DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 18-APR-2006, entry version 46. DE Proteinase-activated receptor 4 precursor (PAR-4) (Thrombin receptor- DE like 3) (Coagulation factor II receptor-like 3). GN Name=F2rl3; Synonyms=Par4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98389762; PubMed=9722561; DOI=10.1074/jbc.273.36.23290; RA Kahn M.L., Hammes S.R., Botka C., Coughlin S.R.; RT "Gene and locus structure and chromosomal localization of the RT protease-activated receptor gene family."; RL J. Biol. Chem. 273:23290-23296(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98379991; PubMed=9716134; DOI=10.1038/29325; RA Kahn M.L., Zheng Y.-W., Huang W., Bigornia V., Zeng D., Moff S., RA Farese R.V. Jr., Tam C., Coughlin S.R.; RT "A dual thrombin receptor system for platelet activation."; RL Nature 394:690-694(1998). CC -!- FUNCTION: Receptor for activated thrombin or trypsin coupled to G CC proteins that stimulate phosphoinositide hydrolysis. May play a CC role in platelets activation. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Highly expressed in the spleen. Slight CC expression in the heart, lung, skeletal muscle and kidney. No CC detectable expression in brain, liver or testis. Also detected in CC platelets. CC -!- PTM: A proteolytic cleavage generates a new N-terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF080215; AAC28861.1; -; mRNA. DR UniGene; Mm.12948; -. DR Ensembl; ENSMUSG00000050147; Mus musculus. DR MGI; MGI:1298207; F2rl3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003944; Prot_act_rcpt_4. DR InterPro; IPR003912; Protea_act_rcpt. DR PANTHER; PTHR19264:SF136; Prot4_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01428; PROTEASEAR. DR PRINTS; PR01430; PROTEASEAR4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Blood coagulation; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Signal; Transducer; Transmembrane. FT SIGNAL 1 16 Potential. FT PROPEP 17 59 Removed for receptor activation (By FT similarity). FT /FTId=PRO_0000012764. FT CHAIN 60 396 Proteinase-activated receptor 4. FT /FTId=PRO_0000012765. FT TOPO_DOM 60 94 Extracellular (Potential). FT TRANSMEM 95 115 1 (Potential). FT TOPO_DOM 116 120 Cytoplasmic (Potential). FT TRANSMEM 121 141 2 (Potential). FT TOPO_DOM 142 162 Extracellular (Potential). FT TRANSMEM 163 183 3 (Potential). FT TOPO_DOM 184 203 Cytoplasmic (Potential). FT TRANSMEM 204 224 4 (Potential). FT TOPO_DOM 225 255 Extracellular (Potential). FT TRANSMEM 256 276 5 (Potential). FT TOPO_DOM 277 295 Cytoplasmic (Potential). FT TRANSMEM 296 316 6 (Potential). FT TOPO_DOM 317 331 Extracellular (Potential). FT TRANSMEM 332 355 7 (Potential). FT TOPO_DOM 356 396 Cytoplasmic (Potential). FT COMPBIAS 374 377 Poly-Ser. FT SITE 59 60 Cleavage (by thrombin) (By similarity). FT CARBOHYD 68 68 N-linked (GlcNAc...) (Potential). FT DISULFID 161 240 By similarity. SQ SEQUENCE 396 AA; 42704 MW; E96636F4804FD3E7 CRC64; MCWPLLYPLV LGLSISLAEG IQTPSIYDDV ESTRGSHEGP LGPTVELKEP KSSDKPNPRG YPGKFCANDS DTLELPASSQ ALLLGWVSTR LVPALYGLVV AVGLPANGLA LWVLATRVPR LPSTILLTNL AVADSLLALV PPPRLAYHLR GQRWPFGEAA CRVATAALYG HMYGSVLLLA AVSLDRYLAL VHPLRARALR GQRLTTGLCL VAWLSAATLA LPLTLHRQTF RLAGSDRMLC HDALPLTEQT SHWRPAFICL AVLGCFVPLL AMGLCYGATL RALAANGQRY SHALRLTALV LFSAVASFTP SNVLLVLHYS NPSPEAWGNL YGAYVPSLAL STLNSCVDPF IYYYVSHEFR EKVRAMLCRQ PEASSSSQAS REAGSRGTAI CSSTLL // ID GALR2_MOUSE STANDARD; PRT; 371 AA. AC O88854; Q9Z2B0; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 18-APR-2006, entry version 42. DE Galanin receptor type 2 (GAL2-R) (GALR2). GN Name=Galr2; Synonyms=Galnr2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/Sv; RX MEDLINE=99048961; PubMed=9832121; RA Kolakowski L.F. Jr., O'Neill G.P., Howard A.D., Broussard S.R., RA Sullivan K.A., Feighner S.D., Sawzdargo M., Nguyen T., Kargman S., RA Shiao L.-L., Hreniuk D.L., Tan C.P., Evans J., Abramovitz M., RA Chateauneuf A., Coulombe N., Ng G., Johnson M.P., Tharian A., RA Khoshbouei H., George S.R., Smith R.G., O'Dowd B.F.; RT "Molecular characterization and expression of cloned human galanin RT receptors GALR2 and GALR3."; RL J. Neurochem. 71:2239-2251(1998). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/Sv; RX MEDLINE=99048962; PubMed=9832122; RA Pang L., Hashemi T., Lee H.J., Maguire M., Graziano M.P., Bayne M., RA Hawes B., Wong G., Wang S.; RT "The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, RT and functional characterization."; RL J. Neurochem. 71:2252-2259(1998). CC -!- FUNCTION: Receptor for the hormone galanin and for GALP. The CC activity of this receptor is mediated by G proteins that activate CC the phospholipase C/protein kinase C pathway (via Gq) and that CC inhibit adenylyl cyclase (via Gi). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF042784; AAC36589.1; -; Genomic_DNA. DR EMBL; AF077375; AAC95468.1; -; mRNA. DR UniGene; Mm.57149; -. DR Ensembl; ENSMUSG00000020793; Mus musculus. DR MGI; MGI:1337018; Galr2. DR GO; GO:0031175; P:neurite morphogenesis; IDA. DR InterPro; IPR000405; Galanin_rcpt. DR InterPro; IPR003907; Galnin_2_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01419; GALANIN2R. DR PRINTS; PR00663; GALANINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 371 Galanin receptor type 2. FT /FTId=PRO_0000069467. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT TOPO_DOM 49 59 Cytoplasmic (Potential). FT TRANSMEM 60 80 2 (Potential). FT TOPO_DOM 81 98 Extracellular (Potential). FT TRANSMEM 99 120 3 (Potential). FT TOPO_DOM 121 140 Cytoplasmic (Potential). FT TRANSMEM 141 161 4 (Potential). FT TOPO_DOM 162 186 Extracellular (Potential). FT TRANSMEM 187 207 5 (Potential). FT TOPO_DOM 208 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT TOPO_DOM 258 259 Extracellular (Potential). FT TRANSMEM 260 280 7 (Potential). FT TOPO_DOM 281 371 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT DISULFID 97 174 By similarity. FT CONFLICT 130 130 M -> L (in Ref. 2). FT CONFLICT 184 188 RAMDL -> PWNS (in Ref. 2). FT CONFLICT 192 193 VF -> CL (in Ref. 2). FT CONFLICT 221 221 A -> V (in Ref. 2). FT CONFLICT 345 360 SEAAGPLVPAPALPNC -> KRGSRAPRPRTRTSQT (in FT Ref. 2). SQ SEQUENCE 371 AA; 40534 MW; 359F127CDEE92659 CRC64; MNGSDSQGAE DSSQEGGGGW QPEAVLVPLF FALIFLVGAV GNALVLAVLL RGGQAVSTTN LFILNLGVAD LCFILCCVPF QATIYTLDDW VFGSLLCKAV HFLIFLTMHA SSFTLAAVSL DRYLAIRYPM HSRELRTPRN ALAAIGLIWG LALLFSGPYL SYYSQSQLAN LTVCHPAWSA PRRRAMDLCT FVFSYLLPVL VLSLTYARTL HYLWRTVDPV AAGSGSQRAK RKVTRMIVIV AVLFCLCWMP HHALILCVWF GRFPLTRATY ALRILSHLVS YANSCVNPIV YALVSKHFRK GFRKICAGLL RRAPRRASGR VCILAPGNHS GGMLEPESTD LTQVSEAAGP LVPAPALPNC TTLSRTLDPA C // ID GALR1_MOUSE STANDARD; PRT; 348 AA. AC P56479; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 1. DT 04-APR-2006, entry version 39. DE Galanin receptor type 1 (GAL1-R) (GALR1). GN Name=Galr1; Synonyms=Galnr, Galnr1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RX MEDLINE=97415411; PubMed=9271210; DOI=10.1016/S0014-5793(97)00695-9; RA Wang S., He C., Maguire M.T., Clemmons A.L., Burrier R.E., Guzzi M.F., RA Strader C.D., Parker E.M., Bayne M.L.; RT "Genomic organization and functional characterization of the mouse RT GalR1 galanin receptor."; RL FEBS Lett. 411:225-230(1997). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129; RX MEDLINE=98035873; PubMed=9367674; DOI=10.1006/geno.1997.4960; RA Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., RA Bottema C.D.K., Shine J., Iismaa T.P.; RT "Structural organization of the mouse and human GALR1 galanin receptor RT genes (Galnr and GALNR) and chromosomal localization of the mouse RT gene."; RL Genomics 45:496-508(1997). CC -!- FUNCTION: Receptor for the hormone galanin. The activity of this CC receptor is mediated by G proteins that inhibit adenylate cyclase CC activity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Three cysteine residues are found in the C-terminus, at least CC one of which may be palmitoylated (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y15004; CAA75237.1; -; mRNA. DR EMBL; U90657; AAB87748.1; -; Genomic_DNA. DR EMBL; U90655; AAB87748.1; JOINED; Genomic_DNA. DR EMBL; U90656; AAB87748.1; JOINED; Genomic_DNA. DR UniGene; Mm.6219; -. DR Ensembl; ENSMUSG00000024553; Mus musculus. DR MGI; MGI:1096364; Galr1. DR GO; GO:0004966; F:galanin receptor activity; TAS. DR InterPro; IPR000405; Galanin_rcpt. DR InterPro; IPR003906; Galnin_1_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF157; Galnin1_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01418; GALANIN1R. DR PRINTS; PR00663; GALANINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 348 Galanin receptor type 1. FT /FTId=PRO_0000069464. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 55 1 (Potential). FT TOPO_DOM 56 70 Cytoplasmic (Potential). FT TRANSMEM 71 91 2 (Potential). FT TOPO_DOM 92 109 Extracellular (Potential). FT TRANSMEM 110 131 3 (Potential). FT TOPO_DOM 132 151 Cytoplasmic (Potential). FT TRANSMEM 152 172 4 (Potential). FT TOPO_DOM 173 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT TOPO_DOM 219 247 Cytoplasmic (Potential). FT TRANSMEM 248 268 6 (Potential). FT TOPO_DOM 269 270 Extracellular (Potential). FT TRANSMEM 271 291 7 (Potential). FT TOPO_DOM 292 348 Cytoplasmic (Potential). FT LIPID 319 319 S-palmitoyl cysteine (By similarity). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 182 182 N-linked (GlcNAc...) (Potential). FT DISULFID 108 186 By similarity. SQ SEQUENCE 348 AA; 39114 MW; 6F52D752BAA19F9A CRC64; MELAMVNLSE GNGSDPEPPA PESRPLFGIG VENFITLVVF GLIFAMGVLG NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGFIW ALSIAMASPV AYHQRLFHRD SNQTFCWEQW PNKLHKKAYV VCTFVFGYLL PLLLICFCYA KVLNHLHKKL KNMSKKSEAS KKKTAQTVLV VVVVFGISWL PHHVVHLWAE FGAFPLTPAS FFFRITAHCL AYSNSSVNPI IYAFLSENFR KAYKQVFKCH VCDESPRSET KENKSRMDTP PSTNCTHV // ID GPR54_ORENI STANDARD; PRT; 377 AA. AC Q6BD04; DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 13-SEP-2004, sequence version 1. DT 07-MAR-2006, entry version 15. DE G-protein coupled receptor 54. GN Name=GPR54; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Labroidei; OC Cichlidae; African cichlids; Pseudocrenilabrinae; Tilapiini; OC Oreochromis. OX NCBI_TaxID=8128; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND POSSIBLE FUNCTION. RC TISSUE=Embryonic brain; RX PubMed=15155576; DOI=10.1210/en.2004-0395; RA Parhar I.S., Ogawa S., Sakuma Y.; RT "Laser-captured single digoxigenin-labeled neurons of gonadotropin- RT releasing hormone types reveal a novel G protein-coupled receptor RT (Gpr54) during maturation in cichlid fish."; RL Endocrinology 145:3613-3618(2004). CC -!- FUNCTION: Receptor speculated to be essential for sexual CC development. May regulate gonadotropin-releasing hormone (GnRH) CC secretion. The receptor expression could be a "stop signal" for CC GnRH1, GnRH2, and GnRH3 neuronal migration, leading to suppression CC of cell growth and modulation of GnRH secretion, which is CC important for normal sexual development. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in a significantly high percentage CC (45-60%) of mature GnRH1, GnRH2, and GnRH3 neurons and in immature CC GnRH3 neurons, which had migrated to the vicinity of their final CC locations in the brain. Only 5% of immature GnRH1 and GnRH2 CC neurons have receptor transcripts. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB162143; BAD34454.1; -; mRNA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008103; KiSS_1_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01728; KISS1RECEPTR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 377 G-protein coupled receptor 54. FT /FTId=PRO_0000069698. FT TOPO_DOM 1 49 Extracellular (Potential). FT TRANSMEM 50 70 1 (Potential). FT TOPO_DOM 71 91 Cytoplasmic (Potential). FT TRANSMEM 92 112 2 (Potential). FT TOPO_DOM 113 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT TOPO_DOM 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT TOPO_DOM 182 209 Extracellular (Potential). FT TRANSMEM 210 230 5 (Potential). FT TOPO_DOM 231 269 Cytoplasmic (Potential). FT TRANSMEM 270 290 6 (Potential). FT TOPO_DOM 291 305 Extracellular (Potential). FT TRANSMEM 306 328 7 (Potential). FT TOPO_DOM 329 377 Cytoplasmic (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT DISULFID 118 198 By similarity. SQ SEQUENCE 377 AA; 43204 MW; CFCD448F3872F1BF CRC64; MYSSEELWNS TEQVWINGSG TNFSLGRHED DEEEEGDKHP FFTDAWLVPL FFSLIMLVGL VGNSLVIYVI SKHRQMRTAT NFYIANLAAT DIIFLVCCVP FTATLYPLPG WIFGNFMCKF VAFLQQVTVQ ATCITLTAMS GDRCYVTVYP LKSLRHRTPK VAMIVSICIW IGSFVLSTPI LMYQRIEEGY WYGPRQYCME RFPSKTHERA FILYQFIAAY LLPVLTISFC YTLMVKRVGQ PTVEPVDNNY QVNLLSERTI SIRSKVSKMV VVIVLLFAIC WGPIQIFVLF QSFYPNYQPN YATYKIKTWA NCMSYANSSV NPIVYGFMGA SFQKSFRKTF PFLFKHKVRD SSMASRTANA EIKFVAAEEG NNNNAVN // ID MCHR2_MACFA STANDARD; PRT; 340 AA. AC Q8SQ54; DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 18-APR-2006, entry version 25. DE Melanin-concentrating hormone receptor 2 (MCH receptor 2) (MCHR-2) DE (MCH-R2) (MCH2R) (MCH-2R) (MCH2) (G-protein coupled receptor 145) DE (GPRv17). GN Name=MCHR2; Synonyms=GPR145; OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M., RA Kamohara M., Saito T., Soga T., Saito Y., Oda T., Masuho Y., RA Furuichi K.; RT "Molecular characterization of a novel melanin-concentrating hormone RT receptor: evidence of its expression in lateral hypothalamus."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to G CC proteins that activate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB058850; BAB87843.1; -; mRNA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008362; MCH2_receptor. DR InterPro; IPR008361; MCH_rcpt. DR PANTHER; PTHR19264:SF163; MCH2_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01784; MCH2RECEPTOR. DR PRINTS; PR01783; MCHRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 340 Melanin-concentrating hormone receptor 2. FT /FTId=PRO_0000069741. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 57 1 (Potential). FT TOPO_DOM 58 69 Cytoplasmic (Potential). FT TRANSMEM 70 92 2 (Potential). FT TOPO_DOM 93 106 Extracellular (Potential). FT TRANSMEM 107 129 3 (Potential). FT TOPO_DOM 130 149 Cytoplasmic (Potential). FT TRANSMEM 150 172 4 (Potential). FT TOPO_DOM 173 198 Extracellular (Potential). FT TRANSMEM 199 221 5 (Potential). FT TOPO_DOM 222 252 Cytoplasmic (Potential). FT TRANSMEM 253 272 6 (Potential). FT TOPO_DOM 273 286 Extracellular (Potential). FT TRANSMEM 287 309 7 (Potential). FT TOPO_DOM 310 340 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 340 AA; 38770 MW; BD22CF1972332439 CRC64; MNPFHSSCWN TSAELSNKSW NKEFAYQTAS AVDTVILPSM IGIICSTGLV GNILIVFTII RSRKKTVPDI YICNLAVADL VHIIGMPFLI HQWARGGEWV FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTSWRTRYKT IRINLGLWAA SFILALPVWI YSKVIKFKDG VESCAFDLTS PDDVLWYTLY LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT KMVLVLVAVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS INPFLYILLS GNFQKRLPQI QRRVTDKEIK NMGNTLKSHF // ID SSR4_MOUSE STANDARD; PRT; 384 AA. AC P49660; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 18-APR-2006, entry version 44. DE Somatostatin receptor type 4 (SS4R). GN Name=Sstr4; Synonyms=Smstr4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; TISSUE=Liver; RX MEDLINE=96194903; PubMed=8654950; DOI=10.1016/0378-1119(95)00748-2; RA Schwabe W., Brennan M.B., Hochgeschwender U.; RT "Isolation and characterization of the mouse (Mus musculus) RT somatostatin receptor type-4-encoding gene (mSSTR4)."; RL Gene 168:233-235(1996). CC -!- FUNCTION: Receptor for somatostatin-14. The activity of this CC receptor is mediated by G proteins which inhibits adenylyl CC cyclase. It is functionally coupled not only to inhibition of CC adenylate cyclase, but also to activation of both arachidonate CC release and mitogen-activated protein (MAP) kinase cascade. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U26176; AAA67561.1; -; Genomic_DNA. DR PIR; JC4629; JC4629. DR UniGene; Mm.35324; -. DR HSSP; P02699; 1BOJ. DR Ensembl; ENSMUSG00000037014; Mus musculus. DR MGI; MGI:105372; Sstr4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000586; Somatstn_rcpt. DR InterPro; IPR001512; Somatstn_rcpt_4. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00590; SOMATOSTTN4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 384 Somatostatin receptor type 4. FT /FTId=PRO_0000070128. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 69 1 (Potential). FT TOPO_DOM 70 79 Cytoplasmic (Potential). FT TRANSMEM 80 105 2 (Potential). FT TOPO_DOM 106 116 Extracellular (Potential). FT TRANSMEM 117 138 3 (Potential). FT TOPO_DOM 139 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT TOPO_DOM 182 203 Extracellular (Potential). FT TRANSMEM 204 228 5 (Potential). FT TOPO_DOM 229 254 Cytoplasmic (Potential). FT TRANSMEM 255 280 6 (Potential). FT TOPO_DOM 281 287 Extracellular (Potential). FT TRANSMEM 288 311 7 (Potential). FT TOPO_DOM 312 384 Cytoplasmic (Potential). FT LIPID 323 323 S-palmitoyl cysteine (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT DISULFID 115 194 By similarity. SQ SEQUENCE 384 AA; 42090 MW; 04DB0751481C6BFB CRC64; MNAPATLLRG VEDTTWTPGI NASWAPEQEE DAMGSDGTGT AGMVTIQCIY ALVCLVGLVG NALVIFVILR YAKMKTATNI YLLNLAVADE LFMLSVPFVR SAAALRHWPF GAVLCRAVLS VDGLNMFTSV FCLTVLSVDR YVAVVHPLRT ATYRRPSVAK LINLGVWLAS LLVTLPIAVF ADTRPARGGE AVACNLHWPH PAWSAVFVIY TFLLGFLPPV LAIGLCYLLI VGKMRAVALR GGWQQRRRSE KKITRLVLMV VTVFVLCWMP FYVVQLLNLF VTSLDATVNH VSLILSYANS CANPILYGFL SDNFRRSFQR VLCLRCCLLE TTGGAEEEPL DYYATALKSR GGAGCICPPL PCQQEPVQAE PGCKQVPFTK TTTF // ID SSR5_MOUSE STANDARD; PRT; 362 AA. AC O08858; O08998; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 04-APR-2006, entry version 40. DE Somatostatin receptor type 5 (SS5R). GN Name=Sstr5; Synonyms=Smstr5; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; TISSUE=Liver; RX MEDLINE=97444289; PubMed=9300821; DOI=10.1016/S0378-1119(97)00156-X; RA Lublin A.L., Diehl N.L., Hochgeschwender U.; RT "Isolation and characterization of the gene encoding the type 5 mouse RT (Mus musculus) somatostatin receptor (msst5)."; RL Gene 195:63-66(1997). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RA Moldovan S., DeMayo F., Brunicardi F.C.; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=BALB/c; TISSUE=Liver; RA Gordon D.F., Woodmansee W.W., Wood W.M., Knauf H., James R.A.; RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RA Baumeister H., Roosterman D., Schafer J., Kreuzer O., Meyerhof W.; RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for somatostatin-28. The activity of this CC receptor is mediated by G proteins which inhibit adenylyl cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U82697; AAC53353.1; -; Genomic_DNA. DR EMBL; AF004740; AAB61418.1; -; Genomic_DNA. DR EMBL; AF030441; AAB86492.1; -; Genomic_DNA. DR EMBL; AF035777; AAB88302.1; ALT_INIT; Genomic_DNA. DR UniGene; Mm.353282; -. DR HSSP; P02699; 1F88. DR Ensembl; ENSMUSG00000050824; Mus musculus. DR MGI; MGI:894282; Sstr5. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000586; Somatstn_rcpt. DR InterPro; IPR001184; Somatstn_rcpt_5. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00591; SOMATOSTTN5R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 362 Somatostatin receptor type 5. FT /FTId=PRO_0000070131. FT TOPO_DOM 1 35 Extracellular (Potential). FT TRANSMEM 36 63 1 (Potential). FT TOPO_DOM 64 73 Cytoplasmic (Potential). FT TRANSMEM 74 99 2 (Potential). FT TOPO_DOM 100 110 Extracellular (Potential). FT TRANSMEM 111 132 3 (Potential). FT TOPO_DOM 133 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 4 (Potential). FT TOPO_DOM 176 195 Extracellular (Potential). FT TRANSMEM 196 220 5 (Potential). FT TOPO_DOM 221 246 Cytoplasmic (Potential). FT TRANSMEM 247 272 6 (Potential). FT TOPO_DOM 273 282 Extracellular (Potential). FT TRANSMEM 283 307 7 (Potential). FT TOPO_DOM 308 362 Cytoplasmic (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT CARBOHYD 185 185 N-linked (GlcNAc...) (Potential). FT DISULFID 109 184 By similarity. FT CONFLICT 99 99 V -> VV (in Ref. 1). FT CONFLICT 303 305 YGF -> LWL (in Ref. 2). SQ SEQUENCE 362 AA; 39948 MW; AA091DDD570FDFAB CRC64; MEPLSLASTP SWNASAASSG SHNWSLVDPV SPMGARAVLV PVLYLLVCTV GLGGNTLVIY VVLRYAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVS YWPFGSFLCR LVMTLDGINQ FTSIFCLMVM SVDRYLAVVH PLRSARWRRP RVAKLASAAV WVFSLLMSLP LLVFADVQEG WGTCNLSWPE PVGLWGAAFI TYTSVLGFFG PLLVICLCYL LIVVKVKAAG MRVGSSRRRR SERKVTRMVV VVVLVFVGCW LPFFIVNIVN LAFTLPEEPT SAGLYFFVVV LSYANSCANP LLYGFLSDNF RQSFRKALCL RRGYGVEDAD AIEPRPDKSG RPQTTLPTRS CEANGLMQTS RL // ID OPRD_MOUSE STANDARD; PRT; 372 AA. AC P32300; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 18-APR-2006, entry version 49. DE Delta-type opioid receptor (DOR-1) (K56) (MSL-2). GN Name=Oprd1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=93101664; PubMed=1334555; RA Kieffer B.L., Befort K., Gaveriaux-Ruff C., Hirth C.G.; RT "The delta-opioid receptor: isolation of a cDNA by expression cloning RT and pharmacological characterization."; RL Proc. Natl. Acad. Sci. U.S.A. 89:12048-12052(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=93110361; PubMed=1335167; RA Evans C.J., Keith D.E. Jr., Morrison H., Magendzo K., Edwards R.H.; RT "Cloning of a delta opioid receptor by functional expression."; RL Science 258:1952-1955(1992). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=93342064; PubMed=8393575; RA Yasuda K., Raynor K., Kong H., Breder C.D., Takeda J., Reisine T., RA Bell G.I.; RT "Cloning and functional comparison of kappa and delta opioid receptors RT from mouse brain."; RL Proc. Natl. Acad. Sci. U.S.A. 90:6736-6740(1993). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=93391482; PubMed=8397421; RA Keith D.E. Jr., Anton B., Evans C.J.; RT "Characterization and mapping of a delta opioid receptor clone from RT NG108-15 cells."; RL Proc. West. Pharmacol. Soc. 36:299-306(1993). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-372. RX MEDLINE=94022364; PubMed=8415697; RA Bzdega T., Chin H., Kim K., Jung H.H., Kozak C.A., Klee W.A.; RT "Regional expression and chromosomal localization of the delta opiate RT receptor gene."; RL Proc. Natl. Acad. Sci. U.S.A. 90:9305-9309(1993). RN [6] RP 3D-STRUCTURE MODELING. RX MEDLINE=97001837; PubMed=8844829; RA Alkorta I., Loew G.H.; RT "A 3D model of the delta opioid receptor and ligand-receptor RT complexes."; RL Protein Eng. 9:573-583(1996). CC -!- FUNCTION: Inhibits neurotransmitter release by reducing calcium CC ion currents and increasing potassium ion conductance. Highly CC stereoselective. receptor for enkephalins. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain, with high concentrations in the basal CC ganglia and limbic regions. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L06322; AAA37522.1; -; mRNA. DR EMBL; L07271; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; L11064; AAA37520.1; -; mRNA. DR EMBL; S65335; AAA16009.1; -; mRNA. DR EMBL; S66181; AAB28546.1; -; mRNA. DR PIR; B48227; B48227. DR UniGene; Mm.5243; -. DR Ensembl; ENSMUSG00000050511; Mus musculus. DR MGI; MGI:97438; Oprd1. DR GO; GO:0016021; C:integral to membrane; IDA. DR GO; GO:0005624; C:membrane fraction; IDA. DR GO; GO:0004986; F:delta-opioid receptor activity; IDA. DR GO; GO:0008344; P:adult locomotory behavior; IMP. DR GO; GO:0007193; P:G-protein signaling, adenylate cyclase inhi...; IDA. DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA. DR InterPro; IPR000321; Delta_opi_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001418; Opioid_rcpt. DR PANTHER; PTHR19264:SF166; Opioid_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00525; DELTAOPIOIDR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00384; OPIOIDR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 372 Delta-type opioid receptor. FT /FTId=PRO_0000069963. FT TOPO_DOM 1 45 Extracellular (Potential). FT TRANSMEM 46 75 1 (Potential). FT TOPO_DOM 76 84 Cytoplasmic (Potential). FT TRANSMEM 85 102 2 (Potential). FT TOPO_DOM 103 124 Extracellular (Potential). FT TRANSMEM 125 144 3 (Potential). FT TOPO_DOM 145 174 Cytoplasmic (Potential). FT TRANSMEM 175 190 4 (Potential). FT TOPO_DOM 191 215 Extracellular (Potential). FT TRANSMEM 216 238 5 (Potential). FT TOPO_DOM 239 261 Cytoplasmic (Potential). FT TRANSMEM 262 284 6 (Potential). FT TOPO_DOM 285 293 Extracellular (Potential). FT TRANSMEM 294 310 7 (Potential). FT TOPO_DOM 311 372 Cytoplasmic (Potential). FT LIPID 333 333 S-palmitoyl cysteine (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT DISULFID 121 198 By similarity. SQ SEQUENCE 372 AA; 40561 MW; BC3B3BBD2E52D3F9 CRC64; MELVPSARAE LQSSPLVNLS DAFPSAFPSA GANASGSPGA RSASSLALAI AITALYSAVC AVGLLGNVLV MFGIVRYTKL KTATNIYIFN LALADALATS TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTQ PRDGAVVCML QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDIN RRDPLVVAAL HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRTPCGRQ EPGSLRRPRQ ATTRERVTAC TPSDGPGGGA AA // ID OPRK_MOUSE STANDARD; PRT; 380 AA. AC P33534; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 18-APR-2006, entry version 51. DE Kappa-type opioid receptor (KOR-1) (MSL-1). GN Name=Oprk1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RX MEDLINE=93342064; PubMed=8393575; RA Yasuda K., Raynor K., Kong H., Breder C.D., Takeda J., Reisine T., RA Bell G.I.; RT "Cloning and functional comparison of kappa and delta opioid receptors RT from mouse brain."; RL Proc. Natl. Acad. Sci. U.S.A. 90:6736-6740(1993). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=95100967; PubMed=7802669; RA Nishi M., Takeshima H., Mori M., Nakagawara K., Takeuchi T.; RT "Structure and chromosomal mapping of genes for the mouse kappa-opioid RT receptor and an opioid receptor homologue (MOR-C)."; RL Biochem. Biophys. Res. Commun. 205:1353-1357(1994). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=95251663; PubMed=7733933; RA Liu H.C., Lu S., Augustin L.B., Felsheim R.F., Chen H.C., Loh H.H., RA Wei L.N.; RT "Cloning and promoter mapping of mouse kappa opioid receptor gene."; RL Biochem. Biophys. Res. Commun. 209:639-647(1995). RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96084989; PubMed=7499487; DOI=10.1016/0165-5728(95)00116-J; RA Belkowski S.M., Zhu J., Liu-Chen L.Y., Eisenstein T.K., Adler M.W., RA Rogers T.J.; RT "Sequence of kappa-opioid receptor cDNA in the R1.1 thymoma cell RT line."; RL J. Neuroimmunol. 62:113-117(1995). CC -!- FUNCTION: Inhibits neurotransmitter release by reducing calcium CC ion currents and increasing potassium ion conductance. Receptor CC for dynorphins. May play a role in arousal and regulation of CC autonomic and neuroendocrine functions. CC -!- SUBUNIT: Binds SLC9A3R1 (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain (neocortex, hippocampus, amygdala, CC medial habenula, hypothalamus, locus ceruleus, and parabrachial CC nucleus). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L11065; AAA39363.1; -; mRNA. DR EMBL; D31665; BAA06508.1; -; Genomic_DNA. DR EMBL; S77872; AAB34130.2; -; Genomic_DNA. DR EMBL; S77868; AAB34130.2; JOINED; Genomic_DNA. DR EMBL; S77869; AAB34130.2; JOINED; Genomic_DNA. DR EMBL; S81111; AAP32232.1; -; mRNA. DR PIR; A48227; A48227. DR PIR; JC2434; JC2434. DR UniGene; Mm.7977; -. DR Ensembl; ENSMUSG00000025905; Mus musculus. DR MGI; MGI:97439; Oprk1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000452; Kappa_opi_rcpt. DR InterPro; IPR001418; Opioid_rcpt. DR PANTHER; PTHR19264:SF166; Opioid_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00532; KAPPAOPIOIDR. DR PRINTS; PR00384; OPIOIDR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 380 Kappa-type opioid receptor. FT /FTId=PRO_0000069968. FT TOPO_DOM 1 58 Extracellular (Potential). FT TRANSMEM 59 85 1 (Potential). FT TOPO_DOM 86 95 Cytoplasmic (Potential). FT TRANSMEM 96 117 2 (Potential). FT TOPO_DOM 118 132 Extracellular (Potential). FT TRANSMEM 133 154 3 (Potential). FT TOPO_DOM 155 173 Cytoplasmic (Potential). FT TRANSMEM 174 196 4 (Potential). FT TOPO_DOM 197 222 Extracellular (Potential). FT TRANSMEM 223 247 5 (Potential). FT TOPO_DOM 248 275 Cytoplasmic (Potential). FT TRANSMEM 276 299 6 (Potential). FT TOPO_DOM 300 311 Extracellular (Potential). FT TRANSMEM 312 333 7 (Potential). FT TOPO_DOM 334 380 Cytoplasmic (Potential). FT LIPID 345 345 S-palmitoyl cysteine (Potential). FT CARBOHYD 25 25 N-linked (GlcNAc...) (Potential). FT CARBOHYD 39 39 N-linked (GlcNAc...) (Potential). FT DISULFID 131 210 By similarity. FT CONFLICT 211 211 S -> L (in Ref. 2 and 3). FT CONFLICT 231 231 F -> V (in Ref. 2 and 3). SQ SEQUENCE 380 AA; 42652 MW; FA4FC947D4545318 CRC64; MESPIQIFRG DPGPTCSPSA CLLPNSSSWF PNWAESDSNG SVGSEDQQLE SAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN LALADALVTT TMPFQSAVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLASSVG ISAIVLGGTK VREDVDVIEC SLQFPDDEYS WWDLFMKICV FVFAFVIPVL IIIVCYTLMI LRLKSVRLLS GSREKDRNLR RITKLVLVVV AVFIICWTPI HIFILVEALG STSHSTAALS SYYFCIALGY TNSSLNPVLY AFLDENFKRC FRDFCFPIKM RMERQSTNRV RNTVQDPASM RDVGGMNKPV // ID NPY1R_CANFA STANDARD; PRT; 382 AA. AC O02813; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-DEC-1998, sequence version 2. DT 02-MAY-2006, entry version 38. DE Neuropeptide Y receptor type 1 (NPY1-R). GN Name=NPY1R; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=99017380; PubMed=9802394; DOI=10.1016/S0167-0115(98)00053-6; RA Malmstroem R.E., Hoekfelt T., Bjoerkman J.-A., Nihlen C., Bystroem M., RA Ekstrand A.J., Lundberg J.M.; RT "Characterization and molecular cloning of vascular neuropeptide Y RT receptor subtypes in pig and dog."; RL Regul. Pept. 75:55-70(1998). CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF005778; AAC08046.1; -; mRNA. DR UniGene; Cfa.3576; -. DR Ensembl; ENSCAFG00000008791; Canis familiaris. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000351; NPY1_rcpt. DR InterPro; IPR000611; NPY_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01013; NRPEPTIDEY1R. DR PRINTS; PR01012; NRPEPTIDEYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 382 Neuropeptide Y receptor type 1. FT /FTId=PRO_0000069918. FT TOPO_DOM 1 38 Extracellular (Potential). FT TRANSMEM 39 61 1 (Potential). FT TOPO_DOM 62 71 Cytoplasmic (Potential). FT TRANSMEM 72 93 2 (Potential). FT TOPO_DOM 94 113 Extracellular (Potential). FT TRANSMEM 114 135 3 (Potential). FT TOPO_DOM 136 155 Cytoplasmic (Potential). FT TRANSMEM 156 176 4 (Potential). FT TOPO_DOM 177 209 Extracellular (Potential). FT TRANSMEM 210 231 5 (Potential). FT TOPO_DOM 232 262 Cytoplasmic (Potential). FT TRANSMEM 263 285 6 (Potential). FT TOPO_DOM 286 298 Extracellular (Potential). FT TRANSMEM 299 322 7 (Potential). FT TOPO_DOM 323 382 Cytoplasmic (Potential). FT LIPID 337 337 S-palmitoyl cysteine (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 185 185 N-linked (GlcNAc...) (Potential). FT DISULFID 112 197 By similarity. SQ SEQUENCE 382 AA; 44245 MW; 95B57D20D6299803 CRC64; MNSTSFSQVE NHSIFCNFSE NSQFLAFESD DCHLPLAMIF TLALAYGAVI ILGVTGNLAL IMIILKQKEM RNVTNILIVN LSFSDLLVAI MCLPFTFVYT LMDHWVFGEA MCKLNPFVQC VSITVSIFSL VLIAVERHQL IINPRGWRPN NRHAYVGIAV IWVLAVVSSL PFLIYQVLTD EPFQNVTLDA FKDKYVCFDK FPSDSHRLSY TTLLLMLQYF GPLCFIFICY FKIYIRLKRR NNMMDKMRDN KYRSSETKRI NIMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA MSTMHTDVSK TSLKQASPVA FKKINNDDNE KI // ID NPY4R_MOUSE STANDARD; PRT; 375 AA. AC Q61041; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 18-APR-2006, entry version 43. DE Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide DE receptor 1) (PP1) (NPYR-D). GN Name=Ppyr1; Synonyms=Npy4r; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; RX MEDLINE=96193913; PubMed=8641440; DOI=10.1016/0014-5793(96)00067-1; RA Gregor P., Millham M.L., Feng Y., Decarr L.B., McCaleb M.L., RA Cornfield L.J.; RT "Cloning and characterization of a novel receptor to pancreatic RT polypeptide, a member of the neuropeptide Y receptor family."; RL FEBS Lett. 381:58-62(1996). CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank CC order of affinity of this receptor for pancreatic polypeptides is CC PP >> PYY >= NPY. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Heart, detected in small intestine. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U40189; AAC52442.1; -; Genomic_DNA. DR PIR; S63685; S63685. DR UniGene; Mm.57059; -. DR Ensembl; ENSMUSG00000048337; Mus musculus. DR MGI; MGI:105374; Ppyr1. DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IDA. DR GO; GO:0001601; F:peptide YY receptor activity; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001933; NPY4_rcpt. DR InterPro; IPR000611; NPY_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01015; NRPEPTIDEY4R. DR PRINTS; PR01012; NRPEPTIDEYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 375 Neuropeptide Y receptor type 4. FT /FTId=PRO_0000069936. FT TOPO_DOM 1 40 Extracellular (Potential). FT TRANSMEM 41 63 1 (Potential). FT TOPO_DOM 64 74 Cytoplasmic (Potential). FT TRANSMEM 75 95 2 (Potential). FT TOPO_DOM 96 115 Extracellular (Potential). FT TRANSMEM 116 137 3 (Potential). FT TOPO_DOM 138 157 Cytoplasmic (Potential). FT TRANSMEM 158 178 4 (Potential). FT TOPO_DOM 179 213 Extracellular (Potential). FT TRANSMEM 214 235 5 (Potential). FT TOPO_DOM 236 265 Cytoplasmic (Potential). FT TRANSMEM 266 288 6 (Potential). FT TOPO_DOM 289 301 Extracellular (Potential). FT TRANSMEM 302 325 7 (Potential). FT TOPO_DOM 326 375 Cytoplasmic (Potential). FT LIPID 340 340 S-palmitoyl cysteine (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 187 187 N-linked (GlcNAc...) (Potential). FT DISULFID 114 201 By similarity. SQ SEQUENCE 375 AA; 42634 MW; DFFD31775DBA310E CRC64; MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI ETILGVLGNL CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT YTIMDYWIFG EVLCKMLTFI QCMSVTVSIL SLVLVALERH QLIINPTGWK PSIFQAYLGI VVIWFISCFL SLPFLANSTL NDLFHYNHSK VVEFLEDKVV CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR LQRQKHVFHA HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPQGESE HLPLSTVHTD LSKGSMRMGS KSNFI // ID NPFF2_MOUSE STANDARD; PRT; 417 AA. AC Q924H0; Q8BKR6; DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 10-MAY-2004, sequence version 2. DT 02-MAY-2006, entry version 31. DE Neuropeptide FF receptor 2 (Neuropeptide NPFF receptor) (G-protein DE coupled receptor 74). GN Name=Npffr2; Synonyms=Gpr74, Npff2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Liu Q., Guan X.-M., McDonald T.P., Jiang Q., Zeng Z., Marlene J., RA Williams D.L. Jr., Hong Y., Figueroa D., Clements M.K., Mallee J., RA Wang R., Evans J., Gould R., Austin C.P.; RT "Identification and characterization of two cognate receptors for RT mammalian FMRFamide-like neuropeptides."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). CC -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) CC neuropeptides, also known as morphine-modulating peptides. Can CC also be activated by a variety of naturally ocurring or synthetic CC FMRF-amide like ligands. This receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF330054; AAK94198.1; -; mRNA. DR EMBL; AK050939; BAC34468.1; -; mRNA. DR UniGene; Mm.319690; -. DR Ensembl; ENSMUSG00000035528; Mus musculus. DR MGI; MGI:1860130; Npffr2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005395; NPFF_rcpt. DR InterPro; IPR005397; NPFF_rcpt_2. DR PANTHER; PTHR19264:SF81; NPFF_receptor2; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01570; NPFFRECEPTOR. DR PRINTS; PR01572; NPFFRECEPTR2. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 417 Neuropeptide FF receptor 2. FT /FTId=PRO_0000069916. FT TOPO_DOM 1 45 Extracellular (Potential). FT TRANSMEM 46 66 1 (Potential). FT TOPO_DOM 67 82 Cytoplasmic (Potential). FT TRANSMEM 83 103 2 (Potential). FT TOPO_DOM 104 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT TOPO_DOM 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT TOPO_DOM 182 217 Extracellular (Potential). FT TRANSMEM 218 238 5 (Potential). FT TOPO_DOM 239 274 Cytoplasmic (Potential). FT TRANSMEM 275 295 6 (Potential). FT TOPO_DOM 296 310 Extracellular (Potential). FT TRANSMEM 311 331 7 (Potential). FT TOPO_DOM 332 417 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT CARBOHYD 198 198 N-linked (GlcNAc...) (Potential). FT DISULFID 118 206 By similarity. FT CONFLICT 89 89 I -> T (in Ref. 1). FT CONFLICT 260 260 V -> E (in Ref. 1). FT CONFLICT 368 368 I -> M (in Ref. 1). SQ SEQUENCE 417 AA; 47449 MW; BB8D85EF405D5786 CRC64; MSEKWDSNSS ESWNHIWSGN DTQHHWYSDI NITYVNYYLH QPQVAAVFIS SYLLIFVLCM VGNTVVCFIV IRNRHMHTVT NFFILNLAIS DLLVGIFCMP ITLLDNIIAG WPFGSSMCKI SGLVQGISVA ASVFTLVAIA VDRFRCVVYP FKPKLTVKTA FVTIVIIWGL AIAIMTPSAI MLHVQEEKYY RVRLSSHNKT STVYWCREDW PRHEMRRIYT TVLFATIYLA PLSLIVIMYA RIGASLFKTA AHCTGKQRPV QWHVSKKKQK VIKMLLTVAL LFILSWLPLW TLMMLSDYTD LSPNKLRIIN IYIYPFAHWL AFCNSSVNPI IYGFFNENFR NGFQDAFQIC QKKAKPQEAY SLRAKRNIVI NTSGLLVQEP VSQNPGGENL GCGKSADNPT QESLIEEMGE ATNSTVA // ID OX2R_CANFA STANDARD; PRT; 444 AA. AC Q9TUP7; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 02-MAY-2006, entry version 41. DE Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2). GN Name=HCRTR2; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=99385793; PubMed=10458611; DOI=10.1016/S0092-8674(00)81965-0; RA Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., RA de Jong P.J., Nishino S., Mignot E.; RT "The sleep disorder canine narcolepsy is caused by a mutation in the RT hypocretin receptor 2 gene."; RL Cell 98:365-376(1999). RN [2] RP REVIEW. RX MEDLINE=21237974; PubMed=11340621; DOI=10.1002/bies.1058; RA Hungs M., Mignot E.; RT "Hypocretin/orexin, sleep and narcolepsy."; RL Bioessays 23:397-408(2001). RN [3] RP REVIEW. RX MEDLINE=21178476; PubMed=11283317; DOI=10.1146/annurev.neuro.24.1.429; RA Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.; RT "To eat or to sleep? Orexin in the regulation of feeding and RT wakefulness."; RL Annu. Rev. Neurosci. 24:429-458(2001). RN [4] RP VARIANT NARCOLEPSY LYS-54, AND CHARACTERIZATION OF VARIANT LYS-54. RX MEDLINE=21180003; PubMed=11282968; DOI=10.1101/gr.GR-1610R; RA Hungs M., Fan J., Lin L., Lin X., Maki R.A., Mignot E.; RT "Identification and functional analysis of mutations in the hypocretin RT (orexin) genes of narcoleptic canines."; RL Genome Res. 11:531-539(2001). CC -!- FUNCTION: Nonselective, high-affinity receptor for both orexin-A CC and orexin-B neuropeptides. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- DISEASE: Defects in HCRTR2 are a cause of an autosomal recessive CC form of narcolepsy, observed in labradors, dobermans and CC dachshunds. Narcolepsy is a neurological sleep disorder affecting CC animals and humans, characterized by excessive daytime sleepiness, CC sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) CC sleep, such as cataplexy, hypnagogic hallucinations, and sleep CC paralysis. Cataplexy is a sudden loss of muscle tone triggered by CC emotions, which is the most valuable clinical feature used to CC diagnose narcolepsy. As in humans, most cases of canine narcolepsy CC are sporadic but an autosomal recessive form was also observed. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF164626; AAD49333.1; -; mRNA. DR UniGene; Cfa.3650; -. DR Ensembl; ENSCAFG00000002328; Canis familiaris. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000204; Orexin_rcpt. DR InterPro; IPR004060; Orexin_rcpt_2. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF03827; Orexin_rec2; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01522; OREXIN2R. DR PRINTS; PR01064; OREXINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Disease mutation; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 444 Orexin receptor type 2. FT /FTId=PRO_0000069988. FT TOPO_DOM 1 54 Extracellular (Potential). FT TRANSMEM 55 75 1 (Potential). FT TOPO_DOM 76 88 Cytoplasmic (Potential). FT TRANSMEM 89 110 2 (Potential). FT TOPO_DOM 111 127 Extracellular (Potential). FT TRANSMEM 128 150 3 (Potential). FT TOPO_DOM 151 172 Cytoplasmic (Potential). FT TRANSMEM 173 193 4 (Potential). FT TOPO_DOM 194 224 Extracellular (Potential). FT TRANSMEM 225 247 5 (Potential). FT TOPO_DOM 248 304 Cytoplasmic (Potential). FT TRANSMEM 305 327 6 (Potential). FT TOPO_DOM 328 342 Extracellular (Potential). FT TRANSMEM 343 366 7 (Potential). FT TOPO_DOM 367 444 Cytoplasmic (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT CARBOHYD 202 202 N-linked (GlcNAc...) (Potential). FT VARIANT 54 54 E -> K (in narcolepsy; autosomal FT recessive; loss of function). SQ SEQUENCE 444 AA; 50675 MW; D848A4536D485D6B CRC64; MSGTKLEDSP PCRNWSSAPE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG YIIVFVVALV GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL DRWYAICHPL MFKSTAKRAR NSIVIIWIVS CIIMIPQAIV MECSTMLPGL ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV LAYLQIFRKL WCRQIPGTSS VVQRKWKPLQ PASQPRGPGQ QTKSRISAVA AEIKQIRARR KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS TESRKSLTTQ ISNFDNVSKL SEQVVLTSIS TLPAANGAGP LQNW // ID NK1R_RANCA STANDARD; PRT; 408 AA. AC Q98982; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 07-MAR-2006, entry version 38. DE Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin DE receptor 1). GN Name=TACR1; Synonyms=TAC1R; OS Rana catesbeiana (Bull frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; OC Aquarana. OX NCBI_TaxID=8400; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Sympathetic ganglion; RX MEDLINE=97363687; PubMed=9219980; DOI=10.1016/S0306-4522(97)00027-4; RA Simmons M.A., Brodbeck R.M., Karpitskiy V.V., Schneider C.R., RA Neff D.P.A., Krause J.E.; RT "Molecular characterization and functional expression of a substance P RT receptor from the sympathetic ganglion of Rana catesbeiana."; RL Neuroscience 79:1219-1229(1997). CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide CC substance P. It is probably associated with G proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U67736; AAC05707.1; -; mRNA. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001681; Neurokn_rcpt. DR InterPro; IPR000046; NK1_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01024; NEUROKININ1R. DR PRINTS; PR00244; NEUROKININR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 408 Substance-P receptor. FT /FTId=PRO_0000069889. FT TOPO_DOM 1 32 Extracellular (Potential). FT TRANSMEM 33 55 1 (Potential). FT TOPO_DOM 56 65 Cytoplasmic (Potential). FT TRANSMEM 66 87 2 (Potential). FT TOPO_DOM 88 107 Extracellular (Potential). FT TRANSMEM 108 129 3 (Potential). FT TOPO_DOM 130 149 Cytoplasmic (Potential). FT TRANSMEM 150 170 4 (Potential). FT TOPO_DOM 171 196 Extracellular (Potential). FT TRANSMEM 197 221 5 (Potential). FT TOPO_DOM 222 250 Cytoplasmic (Potential). FT TRANSMEM 251 272 6 (Potential). FT TOPO_DOM 273 283 Extracellular (Potential). FT TRANSMEM 284 308 7 (Potential). FT TOPO_DOM 309 408 Cytoplasmic (Potential). FT LIPID 323 323 S-palmitoyl cysteine (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT DISULFID 106 181 By similarity. SQ SEQUENCE 408 AA; 47011 MW; 300C28AE8820640E CRC64; MNSNISAQND SALNSTIQNG TKINQFIQPP WQIALWSVAY SIIVIVSLVG NIIVMWIIIA HKRMRTVTNY FLVNLAFAEA SMSAFNTVIN FTYAIHNHWY YGLIYCKFHN FFPISAVFTS IYSMTAIALD RYMAIIHPLK PRLSATATKI VICVIWSFSF CMAFPLGYYA DVYPMEGGDI CYLNWPDSEE NRKYEQVYQV LVFCLIYILP LLVIGCAYTF IGMTLWASEI PGDSSDRYHE QVVAKRKVVK MMIVVVCTFA ICWLPFHIFF LLQTLHEMTQ KFYQQFYLAI MWLAMSSTMY NPIIYCCLND RFRIGFKHVF RWCPFIRAGE YEGLELKSTR YLQTQSSMYK ISRIETTVSS VLNTNDEEAE ENGKSSKRLS LDLTSNGSSR SVCKTMSDSS SFYSNNLA // ID NK2R_BOVIN STANDARD; PRT; 384 AA. AC P05363; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1988, sequence version 1. DT 04-APR-2006, entry version 56. DE Substance-K receptor (SKR) (Neurokinin A receptor) (NK-2 receptor) DE (NK-2R) (Tachykinin receptor 2). GN Name=TACR2; Synonyms=TAC2R; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=88039072; PubMed=2823146; DOI=10.1038/329836a0; RA Masu Y., Nakayama K., Tamaki H., Harada Y., Kuno M., Nakanishi S.; RT "cDNA cloning of bovine substance-K receptor through oocyte expression RT system."; RL Nature 329:836-838(1987). CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide CC substance K (neurokinin A). It is associated with G proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC The rank order of affinity of this receptor to tachykinins is: CC substance K > neuromedin K > substance P. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X06295; CAA29621.1; -; mRNA. DR PIR; S00516; S00516. DR UniGene; Bt.323; -. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001681; Neurokn_rcpt. DR InterPro; IPR000913; NK2_rcpt. DR PANTHER; PTHR19264:SF70; NK2_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01025; NEUROKININ2R. DR PRINTS; PR00244; NEUROKININR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 384 Substance-K receptor. FT /FTId=PRO_0000069890. FT TOPO_DOM 1 32 Extracellular (Potential). FT TRANSMEM 33 56 1 (Potential). FT TOPO_DOM 57 69 Cytoplasmic (Potential). FT TRANSMEM 70 90 2 (Potential). FT TOPO_DOM 91 107 Extracellular (Potential). FT TRANSMEM 108 129 3 (Potential). FT TOPO_DOM 130 149 Cytoplasmic (Potential). FT TRANSMEM 150 170 4 (Potential). FT TOPO_DOM 171 196 Extracellular (Potential). FT TRANSMEM 197 218 5 (Potential). FT TOPO_DOM 219 251 Cytoplasmic (Potential). FT TRANSMEM 252 272 6 (Potential). FT TOPO_DOM 273 290 Extracellular (Potential). FT TRANSMEM 291 310 7 (Potential). FT TOPO_DOM 311 384 Cytoplasmic (Potential). FT LIPID 324 324 S-palmitoyl cysteine (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT DISULFID 106 181 By similarity. SQ SEQUENCE 384 AA; 43069 MW; 1EC676BBD7FF1672 CRC64; MGACVVMTDI NISSGLDSNA TGITAFSMPG WQLALWTAAY LALVLVAVMG NATVIWIILA HQRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPGTRA VIAGIWLVAL ALAFPQCFYS TITTDEGATK CVVAWPEDSG GKMLLLYHLI VIALIYFLPL VVMFVAYSVI GLTLWRRSVP GHQAHGANLR HLQAKKKFVK TMVLVVVTFA ICWLPYHLYF ILGTFQEDIY CHKFIQQVYL ALFWLAMSST MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TEEDKMELTY TPSLSTRVNR CHTKEIFFMS GDVAPSEAVN GQAESPQAGV STEP // ID NMUR1_MOUSE STANDARD; PRT; 405 AA. AC O55040; DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1998, sequence version 1. DT 18-APR-2006, entry version 39. DE Neuromedin U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G- DE protein coupled receptor FM-3). GN Name=Nmur1; Synonyms=Gpr66; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY. RX MEDLINE=99000845; PubMed=9782091; DOI=10.1006/geno.1998.5441; RA Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., RA Hreniuk D.L., Smith R.G., Howard A.D.; RT "Cloning and characterization of a human and murine T-cell orphan G- RT protein-coupled receptor similar to the growth hormone secretagogue RT and neurotensin receptors."; RL Genomics 52:223-229(1998). CC -!- FUNCTION: Receptor for the neuromedin U neuropeptide (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Ubiquitously expressed. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: Ref.1 postulated that the intiator methionine is coded by CC a noncanonical leucine codon. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF044602; AAC02681.1; -; mRNA. DR UniGene; Mm.356698; -. DR Ensembl; ENSMUSG00000026237; Mus musculus. DR MGI; MGI:1341898; Nmur1. DR GO; GO:0005887; C:integral to plasma membrane; IC. DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005390; NeuromedU_rcpt. DR InterPro; IPR005391; NeuromedU_rcpt_1. DR PANTHER; PTHR19264:SF55; NeuromedinU1; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01565; NEUROMEDINUR. DR PRINTS; PR01566; NEUROMEDNU1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 405 Neuromedin U receptor 1. FT /FTId=PRO_0000069907. FT TOPO_DOM 1 36 Extracellular (Potential). FT TRANSMEM 37 57 1 (Potential). FT TOPO_DOM 58 73 Cytoplasmic (Potential). FT TRANSMEM 74 94 2 (Potential). FT TOPO_DOM 95 114 Extracellular (Potential). FT TRANSMEM 115 135 3 (Potential). FT TOPO_DOM 136 158 Cytoplasmic (Potential). FT TRANSMEM 159 179 4 (Potential). FT TOPO_DOM 180 212 Extracellular (Potential). FT TRANSMEM 213 233 5 (Potential). FT TOPO_DOM 234 271 Cytoplasmic (Potential). FT TRANSMEM 272 292 6 (Potential). FT TOPO_DOM 293 316 Extracellular (Potential). FT TRANSMEM 317 337 7 (Potential). FT TOPO_DOM 338 405 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT DISULFID 111 196 By similarity. SQ SEQUENCE 405 AA; 45610 MW; F1BA493D3EB81F34 CRC64; MVCNISEFKW PYQPEDLNLT DEALRLKYLG PQQMKQFVPI CVTYLLIFVV GTLGNGLTCT VILRNKTMRT PTNFYLFSLA VSDMLVLLVG LPLELYEMQQ NYPFQLGASA CYFRILLLET VCLASVLNVT ALSVERYVAV VRPLQAKSVM TRAHVRRMVG AIWVLATLFS LPNTSLHGLS QLTVPCRGPV PDSAICSLVG PMDFYKLVVL TTALLFFCLP MVTISVLYLL IGLRLRRERM LLQVEVKGRK TAATQETSHR RIQLQDRGRR QVTKMLFALV VVFGICWAPF HADRIMWSLV YGHSTEGLHL AYQCVHIASG IFFYLGSAAN PVLYSLMSTR FRETFLQALG LGTQCCHRRQ PYHGSHNHIR LTTGSTLCDV GHRNSRDEPL AVNEDPGCQQ ETDPS // ID NMUR2_BOVIN STANDARD; PRT; 407 AA. AC Q58CW4; DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 26-APR-2005, sequence version 1. DT 04-APR-2006, entry version 14. DE Neuromedin U receptor 2 (NMU-R2). GN Name=NMUR2; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Harhay G.P., Sonstegard T.S., Clawson M.L., Heaton M.P., Keele J.W., RA Snelling W.M., Weidmann R.T., Smith T.P.L.; RT "Sequencing and analysis of Bos taurus full-length insert cDNA RT clones."; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for the neuromedin U neuropeptide (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; BT021833; AAX46680.1; -; mRNA. DR UniGene; Bt.37376; -. DR Ensembl; ENSBTAG00000011131; Bos taurus. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005390; NeuromedU_rcpt. DR InterPro; IPR005392; NeuromedU_rcpt_2. DR PANTHER; PTHR19264:SF54; NeuromedinU2; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01565; NEUROMEDINUR. DR PRINTS; PR01567; NEUROMEDNU2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 407 Neuromedin U receptor 2. FT /FTId=PRO_0000069909. FT TOPO_DOM 1 47 Extracellular (Potential). FT TRANSMEM 48 68 1 (Potential). FT TOPO_DOM 69 79 Cytoplasmic (Potential). FT TRANSMEM 80 100 2 (Potential). FT TOPO_DOM 101 120 Extracellular (Potential). FT TRANSMEM 121 139 3 (Potential). FT TOPO_DOM 140 162 Cytoplasmic (Potential). FT TRANSMEM 163 183 4 (Potential). FT TOPO_DOM 184 211 Extracellular (Potential). FT TRANSMEM 212 232 5 (Potential). FT TOPO_DOM 233 262 Cytoplasmic (Potential). FT TRANSMEM 263 283 6 (Potential). FT TOPO_DOM 284 298 Extracellular (Potential). FT TRANSMEM 299 319 7 (Potential). FT TOPO_DOM 320 407 Cytoplasmic (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 191 191 N-linked (GlcNAc...) (Potential). FT DISULFID 116 201 By similarity. SQ SEQUENCE 407 AA; 46343 MW; 6C49046C250DBC22 CRC64; MEKHENVSWM YQQELKDPFK KYLNNTDDYL ALLCGPRRSH LFLPVTAVYA LIFVVGVVGN LLVCLVILRH QTMKTPTNYY LFSLAVSDLL VLLLGMPLEV YEMWRNYPFL FGPVGCYFKT ALFETVCFAS ILSVTTVSVE RYVAVLHPFR AKLKSTRGRA LRILGIVWGL SVLFSLPNTS IHGIKLHYFP NGSIIPGSAT CTVIKPMWIY NFIIQVTSLL FYILPMTVIS VLYYLMGLKL KKDQHLEADK VTANIQRPSR KSVTKMLFVL VLVFAICWAP FHIDRLFFSF VEEWTEPLAA VFNLIHVVSG VFFYLSSAVN PIIYNLLSHR FQAAFRTVIP PSCQQQHSHN HSPGPSMQRN IFLTECHLVE LTEDVAPQFP RQLSVLSSQL PTALCTGQVP RKELAKS // ID NTR2_MOUSE STANDARD; PRT; 417 AA. AC P70310; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 18-APR-2006, entry version 42. DE Neurotensin receptor type 2 (NT-R-2) (Low-affinity levocabastine- DE sensitive neurotensin receptor) (NTRL). GN Name=Ntsr2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/c; TISSUE=Brain; RX MEDLINE=96388216; PubMed=8795617; RA Mazella J., Botto J.-M., Guillemare E., Coppola T., Sarret P., RA Vincent J.-P.; RT "Structure, functional expression, and cerebral localization of the RT levocabastine-sensitive neurotensin/neuromedin N receptor from mouse RT brain."; RL J. Neurosci. 16:5613-5620(1996). CC -!- FUNCTION: Receptor for the tridecapeptide neurotensin. It is CC associated with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed maximally in the cerebellum, CC hyppocampus, piriform cortex and neocortex of adult brain. CC -!- DEVELOPMENTAL STAGE: Expressed poorly in 7-day-old brain. CC Expression increases at day 15 to reach a maximal level in 35-day- CC old brain. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U51908; AAB17285.1; -; mRNA. DR UniGene; Mm.281715; -. DR Ensembl; ENSMUSG00000020591; Mus musculus. DR MGI; MGI:108018; Ntsr2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003986; NT2_rcpt. DR InterPro; IPR003984; NT_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01479; NEUROTENSINR. DR PRINTS; PR01481; NEUROTENSN2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Lipoprotein; Membrane; Palmitate; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 417 Neurotensin receptor type 2. FT /FTId=PRO_0000069950. FT TOPO_DOM 1 32 Extracellular (Potential). FT TRANSMEM 33 55 1 (Potential). FT TOPO_DOM 56 64 Cytoplasmic (Potential). FT TRANSMEM 65 87 2 (Potential). FT TOPO_DOM 88 109 Extracellular (Potential). FT TRANSMEM 110 131 3 (Potential). FT TOPO_DOM 132 154 Cytoplasmic (Potential). FT TRANSMEM 155 176 4 (Potential). FT TOPO_DOM 177 217 Extracellular (Potential). FT TRANSMEM 218 238 5 (Potential). FT TOPO_DOM 239 298 Cytoplasmic (Potential). FT TRANSMEM 299 319 6 (Potential). FT TOPO_DOM 320 338 Extracellular (Potential). FT TRANSMEM 339 359 7 (Potential). FT TOPO_DOM 360 417 Cytoplasmic (Potential). FT LIPID 378 378 S-palmitoyl cysteine (Potential). FT DISULFID 108 194 By similarity. SQ SEQUENCE 417 AA; 46537 MW; EBFDDBD6507223DD CRC64; METSSLWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFALGTAGN ALSVHVVLKA RTGRPGRLRY HVLSLALSAL LLLLISVPME LYNFVWSHYP WVFGDLGCRG YYFVRELCAY ATVLSVASLS AERCLAVCQP LRARRLLTPR RTCRLLSLVW VASLGLALPM AVIMGQKHEM ERADGEPEPA SRVCTVLVSR ASSRSTFQVK RAGLLRSPLW ELTAILNGIT VNHLVALYSQ VPSASAQVNS IPSRLELLSE EGLLGFITWR KTLSLGVQAS LVRHKDASQI RSLQHSAQVL RAIVAVYVIC WLPYHARRLM YCYIPDDGWT DELYDFYHYF YMVTNTLFYV SSAVTPVLYN AVSSSFRKLF LESLSSLCGE QRSVVPLPQE APESTTSTYS FRLWGSPRNP SLGEIQV // ID CCKAR_XENLA STANDARD; PRT; 453 AA. AC P70031; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 04-APR-2006, entry version 36. DE Cholecystokinin receptor (CCK-XLR). OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=96319796; PubMed=8700154; RA Schmitz F., Pratt D.S., Wu M.-J., Kolakowski L.F. Jr., Beinborn M., RA Kopin A.S.; RT "Identification of cholecystokinin-B/gastrin receptor domains that RT confer high gastrin affinity: utilization of a novel Xenopus laevis RT cholecystokinin receptor."; RL Mol. Pharmacol. 50:436-441(1996). CC -!- FUNCTION: Receptor for cholecystokinin. This receptor mediates its CC action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. Has high CC affinity for CCK-8 and low affinities for gastrin-17-I, CCK-4, and CC unsulfated CCK-8. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain and stomach. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U49258; AAB09052.1; -; mRNA. DR UniGene; Xl.1069; -. DR HSSP; P32239; 1L4T. DR InterPro; IPR009126; Cholcskin_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01822; CCYSTOKININR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 453 Cholecystokinin receptor. FT /FTId=PRO_0000069227. FT TOPO_DOM 1 64 Extracellular (Potential). FT TRANSMEM 65 94 1 (Potential). FT TOPO_DOM 95 104 Cytoplasmic (Potential). FT TRANSMEM 105 131 2 (Potential). FT TOPO_DOM 132 142 Extracellular (Potential). FT TRANSMEM 143 164 3 (Potential). FT TOPO_DOM 165 184 Cytoplasmic (Potential). FT TRANSMEM 185 205 4 (Potential). FT TOPO_DOM 206 237 Extracellular (Potential). FT TRANSMEM 238 261 5 (Potential). FT TOPO_DOM 262 343 Cytoplasmic (Potential). FT TRANSMEM 344 364 6 (Potential). FT TOPO_DOM 365 379 Extracellular (Potential). FT TRANSMEM 380 403 7 (Potential). FT TOPO_DOM 404 453 Cytoplasmic (Potential). FT LIPID 401 401 S-palmitoyl cysteine (By similarity). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT CARBOHYD 30 30 N-linked (GlcNAc...) (Potential). FT CARBOHYD 35 35 N-linked (GlcNAc...) (Potential). FT CARBOHYD 39 39 N-linked (GlcNAc...) (Potential). FT DISULFID 141 223 By similarity. SQ SEQUENCE 453 AA; 51157 MW; 06217927B7482678 CRC64; MESLRSLSNI SALHELLCRY SNLSGTLTWN LSSTNGTHNL TTANWPPWNL NCTPILDRKK PSPSDLNLWV RIVMYSVIFL LSVFGNTLII IVLVMNKRLR TITNSFLLSL ALSDLMVAVL CMPFTLIPNL MENFIFGEVI CRAAAYFMGL SVSVSTFNLV AISIERYSAI CNPLKSRVWQ TRSHAYRVIA ATWVLSSIIM IPYLVYNKTV TFPMKDRRVG HQCRLVWPSK QVQQAWYVLL LTILFFIPGV VMIVAYGLIS RELYRGIQFE MDLNKEAKAH KNGVSTPTTI PSGDEGDGCY IQVTKRRNTM EMSTLTPSVC TKMDRARINN SEAKLMAKKR VIRMLIVIVA MFFICWMPIF VANTWKAFDE LSAFNTLTGA PISFIHLLSY TSACVNPLIY CFMNKRFRKA FLGTFSSCIK PCRNFRDTDE DIAATGASLS KFSYTTVSSL GPA // ID V1AR_MICMA STANDARD; PRT; 420 AA. AC Q9WTV8; DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot. DT 30-AUG-2005, sequence version 2. DT 21-MAR-2006, entry version 30. DE Vasopressin V1a receptor (V1aR) (Vascular/hepatic-type arginine DE vasopressin receptor) (Antidiuretic hormone receptor 1a) (AVPR V1a). GN Name=Avpr1a; OS Microtus montanus (Montane vole). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Cricetidae; Arvicolinae; Microtus. OX NCBI_TaxID=88450; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Brain; RX MEDLINE=99394601; PubMed=10466725; DOI=10.1038/23475; RA Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R.; RT "Increased affiliative response to vasopressin in mice expressing the RT V1a receptor from a monogamous vole."; RL Nature 400:766-768(1999). RN [2] RP SEQUENCE REVISION TO 18. RA Young L.J., Nilsen R.A., Insel T.R., Dondaldson Z.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP ROLE IN SOCIAL BEHAVIOR. RX PubMed=15201909; DOI=10.1038/nature02539; RA Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., RA Young L.J.; RT "Enhanced partner preference in a promiscuous species by manipulating RT the expression of a single gene."; RL Nature 429:754-757(2004). CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this CC receptor is mediated by G proteins which activate a phosphatidyl- CC inositol-calcium second messenger system. Involved in social CC memory formation. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- MISCELLANEOUS: In prairie and pine voles, the 5' regulatory region CC of AVPR1A contains a microsatellite region that is virtually CC absent from montane and meadow voles. This species-specific CC microsatellite polymorphism modulates gene expression in a cell- CC type-dependent manner and generates a great individual variability CC in the brain expression pattern. This polymorphism is correlated CC with monogamous social organization. CC -!- MISCELLANEOUS: Prairie voles exhibit a monogamous social structure CC in nature, whereas closely related meadow voles are solitary and CC polygamous. AVPR1A is expressed at higher levels in the ventral CC forebrain of monogamous than in promiscuous vole species, whereas CC dopamine receptor distribution is relatively conserved between CC species. The partner preference formation in the socially CC promiscuous meadow vole is increased by AVPR1A gene transfer into CC the ventral forebrain. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- DATABASE: NAME=Protein Spotlight; NOTE=Issue 52 of November 2004; CC WWW="http://www.expasy.org/spotlight/back_issues/sptlt052.shtml". CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF070010; AAD20955.2; -; Genomic_DNA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001817; Vasoprsn_rcpt. DR InterPro; IPR001224; Vprs_V1A_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PRINTS; PR00752; VASOPRSNV1AR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 420 Vasopressin V1a receptor. FT /FTId=PRO_0000070198. FT TOPO_DOM 1 54 Extracellular (Potential). FT TRANSMEM 55 75 Potential. FT TOPO_DOM 76 92 Cytoplasmic (Potential). FT TRANSMEM 93 113 Potential. FT TOPO_DOM 114 125 Extracellular (Potential). FT TRANSMEM 126 146 Potential. FT TOPO_DOM 147 168 Cytoplasmic (Potential). FT TRANSMEM 169 189 Potential. FT TOPO_DOM 190 225 Extracellular (Potential). FT TRANSMEM 226 246 Potential. FT TOPO_DOM 247 294 Cytoplasmic (Potential). FT TRANSMEM 295 315 Potential. FT TOPO_DOM 316 331 Extracellular (Potential). FT TRANSMEM 332 352 Potential. FT TOPO_DOM 353 420 Cytoplasmic (Potential). FT LIPID 367 367 S-palmitoyl cysteine (By similarity). FT LIPID 368 368 S-palmitoyl cysteine (By similarity). FT CARBOHYD 27 27 N-linked (GlcNAc...) (Potential). FT CARBOHYD 198 198 N-linked (GlcNAc...) (Potential). FT DISULFID 124 205 By similarity. SQ SEQUENCE 420 AA; 47461 MW; B7F7D53D985E3C88 CRC64; MSFPRGSYDP AASNSSPRWP LSAEDANSSR EAAGHQKGSD PSGDVRNEEL AKLEIAVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAASWVLSFL LSTPQYFIFS MIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF ICYHIWRNVR GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY MFFSGHLLQD CVQSFPCCQR MVQKFTKDDS DNMSRRQTSY SNNRSPTNST GTWKDSPKSS RSIRFIPVST // ID OXYR_BOVIN STANDARD; PRT; 391 AA. AC P56449; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 1. DT 04-APR-2006, entry version 31. DE Oxytocin receptor (OT-R). GN Name=OXTR; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=96125187; PubMed=8534370; RA Bathgate R., Rust W., Balvers M., Hartung S., Morley S., Ivell R.; RT "Structure and expression of the bovine oxytocin receptor gene."; RL DNA Cell Biol. 14:1037-1048(1995). CC -!- FUNCTION: Receptor for oxytocin. The activity of this receptor is CC mediated by G proteins which activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF101724; AAC70786.1; -; mRNA. DR UniGene; Bt.140; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR002062; Oxytocn_rcpt. DR InterPro; IPR001817; Vasoprsn_rcpt. DR PANTHER; PTHR19264:SF31; Oxytocn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00665; OXYTOCINR. DR PRINTS; PR00896; VASOPRESSINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 391 Oxytocin receptor. FT /FTId=PRO_0000069997. FT TOPO_DOM 1 38 Extracellular (Potential). FT TRANSMEM 39 63 1 (Potential). FT TOPO_DOM 64 74 Cytoplasmic (Potential). FT TRANSMEM 75 97 2 (Potential). FT TOPO_DOM 98 113 Extracellular (Potential). FT TRANSMEM 114 135 3 (Potential). FT TOPO_DOM 136 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 4 (Potential). FT TOPO_DOM 176 202 Extracellular (Potential). FT TRANSMEM 203 225 5 (Potential). FT TOPO_DOM 226 277 Cytoplasmic (Potential). FT TRANSMEM 278 296 6 (Potential). FT TOPO_DOM 297 311 Extracellular (Potential). FT TRANSMEM 312 334 7 (Potential). FT TOPO_DOM 335 391 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT DISULFID 112 187 By similarity. SQ SEQUENCE 391 AA; 43378 MW; 39161BE63C5C672B CRC64; MEGAFAANWS AEAVNGSAAP PGTEGNRTAG PPQRNEALAR VEVAVLCLIL FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLSR RTDRLAVLVT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLATCY GLISFKIWQN LRLKTAAAAA EAAAGAEGEA ADWAGRAILA RVSNVKLISK AKIRTVKMTF IVVLAFIVCW TPFFFVQMWS VWDADAPKEA SPFIIAMLLA SLNSCCNPWI YMLFTGHLFQ ELVQRFLCCS FRRLKGSRPG ETSVSKKSNS STFVLSQYSS SQRRCSQPST L // ID ITR_CATCO STANDARD; PRT; 390 AA. AC Q90334; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 21-MAR-2006, entry version 37. DE Isotocin receptor (ITR). OS Catostomus commersoni (White sucker). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Catostomidae; Catostomus. OX NCBI_TaxID=7971; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=95385800; PubMed=7656982; DOI=10.1016/0014-5793(95)00832-T; RA Hausmann H., Meyerhof W., Zwiers H., Lederis K., Richter D.; RT "Teleost isotocin receptor: structure, functional expression, mRNA RT distribution and phylogeny."; RL FEBS Lett. 370:227-230(1995). CC -!- FUNCTION: Binds to isotocin. Can also be activated by vasotocin, CC mesotocin, oxytocin and Arg-vasopressin, although these have lower CC potencies than isotocin. Produces an induction of membrane CC chloride currents indicating that it is coupled to the inositol CC phosphate/calcium pathway. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in brain, intestine, bladder, CC skeletal muscle, lateral line, gills and kidney. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X87783; CAA61050.1; -; mRNA. DR PIR; S66497; S66497. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR002062; Oxytocn_rcpt. DR InterPro; IPR001817; Vasoprsn_rcpt. DR PANTHER; PTHR19264:SF31; Oxytocn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00665; OXYTOCINR. DR PRINTS; PR00896; VASOPRESSINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 390 Isotocin receptor. FT /FTId=PRO_0000069694. FT TOPO_DOM 1 48 Extracellular (Potential). FT TRANSMEM 49 69 1 (Potential). FT TOPO_DOM 70 86 Cytoplasmic (Potential). FT TRANSMEM 87 107 2 (Potential). FT TOPO_DOM 108 124 Extracellular (Potential). FT TRANSMEM 125 145 3 (Potential). FT TOPO_DOM 146 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT TOPO_DOM 182 206 Extracellular (Potential). FT TRANSMEM 207 227 5 (Potential). FT TOPO_DOM 228 276 Cytoplasmic (Potential). FT TRANSMEM 277 297 6 (Potential). FT TOPO_DOM 298 311 Extracellular (Potential). FT TRANSMEM 312 332 7 (Potential). FT TOPO_DOM 333 390 Cytoplasmic (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 30 30 N-linked (GlcNAc...) (Potential). FT DISULFID 116 191 By similarity. SQ SEQUENCE 390 AA; 44504 MW; 2C3E9BA244FD6913 CRC64; MEEMFKEQDF WSFNESSRNS TVGNETFGGN QTVNPLKRNE EVAKVEVTVL ALVLFLALAG NLCVLIAIYT AKHTQSRMYY LMKHLSIADL VVAVFQVLPQ LIWDITFRFY GPDFLCRLVK YLQTVGMFAS TYMLVLMSID RCIAICQPLR SLHKRKDRCY VIVSWALSLV FSVPQVYIFS LREIGNGVYD CWGDFVQPWG AKAYITWISL TIYIIPVAIL GGCYGLISFK IWQNFKRKTK KDQCITLTTA ASKANALARV SSVKLVSKAK ITTVKMTFVI VLAYIVCWTP FFFVQMWSAW DPEAPREAMP FIISMLLASL NSCCNPWIYM FFAGHLFHDL KQSLLCCSTL YLKSSQCRCD QEHDSRKSNC STYVIKSTSS QRSITQSSIT // ID V2R_CANFA STANDARD; PRT; 370 AA. AC O77808; DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 02-MAY-2006, entry version 32. DE Vasopressin V2 receptor (Renal-type arginine vasopressin receptor) DE (Antidiuretic hormone receptor) (AVPR V2). GN Name=AVPR2; Synonyms=V2R; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Weber B.I.L., Rascher W.; RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Weber B.I.L., Rascher W.; RT "Organization of the dog vasopressin receptor gene."; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this CC receptor is mediated by G proteins which activate adenylate CC cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y18136; CAA77063.1; -; mRNA. DR EMBL; AJ238150; CAB41598.1; -; Genomic_DNA. DR UniGene; Cfa.3666; -. DR Ensembl; ENSCAFG00000019402; Canis familiaris. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001817; Vasoprsn_rcpt. DR InterPro; IPR000161; Vprsn_rcpt_V2. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PRINTS; PR00898; VASOPRSNV2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 370 Vasopressin V2 receptor. FT /FTId=PRO_0000070207. FT TOPO_DOM 1 37 Extracellular (Potential). FT TRANSMEM 38 62 1 (Potential). FT TOPO_DOM 63 76 Cytoplasmic (Potential). FT TRANSMEM 77 97 2 (Potential). FT TOPO_DOM 98 112 Extracellular (Potential). FT TRANSMEM 113 134 3 (Potential). FT TOPO_DOM 135 158 Cytoplasmic (Potential). FT TRANSMEM 159 179 4 (Potential). FT TOPO_DOM 180 199 Extracellular (Potential). FT TRANSMEM 200 219 5 (Potential). FT TOPO_DOM 220 270 Cytoplasmic (Potential). FT TRANSMEM 271 292 6 (Potential). FT TOPO_DOM 293 307 Extracellular (Potential). FT TRANSMEM 308 327 7 (Potential). FT TOPO_DOM 328 370 Cytoplasmic (Potential). FT LIPID 340 340 S-palmitoyl cysteine (By similarity). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 370 AA; 40200 MW; 8F4E133FAF800B5C CRC64; MLLASTTSAV PRTLSPPTPA GNGSRELLDT RDPLLVQAEL ALLSTVFVAV ALSNGLVLGA LARRVRRGRW APMHVFIGHL CLADLAVALF QVLPQLAWDA TDRFRGPDAL CRAVKYLQMV GMYASSYMIL AMTLDRHRAI CRPMLAYRHG GGARWNRPVL VAWAFSLILS LPQLFIFAQR DVGNGSGVLD CWAHFAEPWG LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHSSLVPGPA ERAGGCRGGH RTGSPSEGAR VSAAMAKTVR MTLVIVIVYV LCWAPFFLVQ LWAAWDPQAP LEGAPFVLLM LLASLNSCTN PWIYAFFSSS VSSELRSLFC WARSRAPPSL GPQEESCATA SSFLAKDTSS // ID DUFFY_CEBAP STANDARD; PRT; 336 AA. AC Q95LF4; DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 18-APR-2006, entry version 26. DE Duffy antigen/chemokine receptor (CD234 antigen). GN Name=DARC; Synonyms=FY; OS Cebus apella (Brown-capped capuchin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Cebinae; Cebus. OX NCBI_TaxID=9515; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Tournamille C., Blancher A., Le Van Kim C., Gane P., Apoil P.-A., RA Nakamoto W., Cartron J.-P., Colin Y.; RT "Sequences, evolution and ligand binding properties of mammalian Duffy RT antigen/receptor for chemokines."; RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Non-specific receptor for many chemokines (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Duffy CC family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF311919; AAL09454.1; -; Genomic_DNA. DR InterPro; IPR005384; Duffy_cmk_rcpt. DR PANTHER; PTHR14181; Dufatg/cmkrecept; 1. DR PRINTS; PR01559; DUFFYANTIGEN. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 336 Duffy antigen/chemokine receptor. FT /FTId=PRO_0000152583. FT TOPO_DOM 1 63 Extracellular (Potential). FT TRANSMEM 64 84 1 (Potential). FT TOPO_DOM 85 95 Cytoplasmic (Potential). FT TRANSMEM 96 116 2 (Potential). FT TOPO_DOM 117 129 Extracellular (Potential). FT TRANSMEM 130 153 3 (Potential). FT TOPO_DOM 154 166 Cytoplasmic (Potential). FT TRANSMEM 167 187 4 (Potential). FT TOPO_DOM 188 207 Extracellular (Potential). FT TRANSMEM 208 228 5 (Potential). FT TOPO_DOM 229 244 Cytoplasmic (Potential). FT TRANSMEM 245 265 6 (Potential). FT TOPO_DOM 266 287 Extracellular (Potential). FT TRANSMEM 288 308 7 (Potential). FT TOPO_DOM 309 336 Cytoplasmic (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT DISULFID 51 276 By similarity. FT DISULFID 129 195 By similarity. SQ SEQUENCE 336 AA; 35837 MW; 5D2CC35884F7B6F1 CRC64; MGNCLHQAEL SPSTENSSQL NLEDLWDFPY NGNDSFPEIN YDASLEAAAP CYSCNLLDDS SLPFFILASV LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPILAPGL GNTRSSALCS LGYCVWYGSA FAQALLLGCH ASLGPKLGAG QVPGLTLGLT VGLWGAAALL TVPITLASGA SDGLCTPIYS TELKALQATH TVACFAIFVL LPLGLFGAKG VKKALGMGPG PWMTILWIWF IFWWPHGVVL GLDFLVRSKL LLLPTCLAQQ VLDLLLNLAE ALTIVHCVAT PLLLALFCHQ ATRTLLPSLP LPERWSSPVD TLGSKS // ID DUFFY_MOUSE STANDARD; PRT; 334 AA. AC Q9QUI6; O35970; Q91VB6; Q920X0; Q920X1; Q920X2; Q920X3; DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot. DT 10-JAN-2003, sequence version 2. DT 18-APR-2006, entry version 44. DE Duffy antigen/chemokine receptor (CD234 antigen). GN Name=Darc; Synonyms=Dfy, Fy; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97458170; PubMed=9314499; RA Luo H., Chaudhuri A., Johnson K.R., Neote K., Zbrzezna V., He Y., RA Pogo A.O.; RT "Cloning, characterization, and mapping of a murine promiscuous RT chemokine receptor gene: homolog of the human Duffy gene."; RL Genome Res. 7:932-941(1997). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skeletal muscle; RA Tournamille C., Colin Y.; RT "Murine skeletal muscle duffy antigen/receptor for chemokine RT glycoprotein (DARC)."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=99449053; PubMed=10520743; RA Tang T., Owen J.D., Du J., Walker C.L., Richmond A.; RT "Molecular cloning and characterization of a mouse gene with homology RT to the Duffy-antigen receptor for chemokines."; RL DNA Seq. 9:129-143(1998). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, RC NJL/Msf, Pgn2, and SWN/Msf; RA Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.; RT "Conspicuous differences among gene genealogies of 21 nuclear genes of RT five Mus musculus subspecies."; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Non-specific receptor for many chemokines (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in liver and brain. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Duffy CC family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF016697; AAC53360.1; -; Genomic_DNA. DR EMBL; AF016584; AAC53354.1; -; mRNA. DR EMBL; AF109159; AAF14225.1; -; mRNA. DR EMBL; U88431; AAF08328.1; -; Genomic_DNA. DR EMBL; AB039074; BAB68598.1; -; Genomic_DNA. DR EMBL; AB039075; BAB68599.1; -; Genomic_DNA. DR EMBL; AB039076; BAB68600.1; -; Genomic_DNA. DR EMBL; AB039077; BAB68601.1; -; Genomic_DNA. DR EMBL; AB039078; BAB68602.1; -; Genomic_DNA. DR EMBL; AB039079; BAB68603.1; -; Genomic_DNA. DR EMBL; AB039080; BAB68604.1; -; Genomic_DNA. DR EMBL; AB039081; BAB68605.1; -; Genomic_DNA. DR EMBL; AB039082; BAB68606.1; -; Genomic_DNA. DR EMBL; BC005583; AAH05583.1; -; mRNA. DR UniGene; Mm.6393; -. DR Ensembl; ENSMUSG00000037872; Mus musculus. DR MGI; MGI:1097689; Dfy. DR GO; GO:0006954; P:inflammatory response; IMP. DR InterPro; IPR005384; Duffy_cmk_rcpt. DR PANTHER; PTHR14181; Dufatg/cmkrecept; 1. DR PRINTS; PR01559; DUFFYANTIGEN. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 334 Duffy antigen/chemokine receptor. FT /FTId=PRO_0000152587. FT TOPO_DOM 1 61 Extracellular (Potential). FT TRANSMEM 62 82 1 (Potential). FT TOPO_DOM 83 93 Cytoplasmic (Potential). FT TRANSMEM 94 114 2 (Potential). FT TOPO_DOM 115 127 Extracellular (Potential). FT TRANSMEM 128 151 3 (Potential). FT TOPO_DOM 152 164 Cytoplasmic (Potential). FT TRANSMEM 165 185 4 (Potential). FT TOPO_DOM 186 205 Extracellular (Potential). FT TRANSMEM 206 226 5 (Potential). FT TOPO_DOM 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 263 6 (Potential). FT TOPO_DOM 264 285 Extracellular (Potential). FT TRANSMEM 286 306 7 (Potential). FT TOPO_DOM 307 334 Cytoplasmic (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT CARBOHYD 32 32 N-linked (GlcNAc...) (Potential). FT CARBOHYD 285 285 N-linked (GlcNAc...) (Potential). FT DISULFID 49 274 By similarity. FT DISULFID 127 193 By similarity. FT VARIANT 10 10 T -> N (in strain: BLG2/Msf, C57BL/10SnJ, FT HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf). FT VARIANT 56 56 D -> G (in strain: BLG2/Msf, C57BL/10SnJ, FT HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf). FT VARIANT 61 61 P -> L (in strain: BLG2/Msf). FT VARIANT 76 76 S -> G (in strain: BLG2/Msf, C57BL/10SnJ, FT CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and FT SWN/Msf). FT VARIANT 178 178 S -> L (in strain: BLG2/Msf, C57BL/10SnJ, FT CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 FT and SWN/Msf). FT VARIANT 188 188 V -> A (in strain: BLG2/Msf, C57BL/10SnJ, FT CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and FT SWN/Msf). FT VARIANT 194 194 T -> A (in strain: BLG2/Msf, C57BL/10SnJ, FT HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf). FT VARIANT 207 207 T -> M (in strain: C57BL/10SnJ, HMI/Msf, FT MSM/Msf and SWN/Msf). FT VARIANT 221 221 L -> P (in strain: BLG2/Msf, C57BL/10SnJ, FT HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf). FT VARIANT 256 256 M -> I (in strain: NJL/Msf). FT VARIANT 268 268 T -> I (in strain: BLG2/Msf, C57BL/10SnJ, FT HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf). SQ SEQUENCE 334 AA; 36694 MW; 21AC4B6147D840C8 CRC64; MGNCLYPVET LSLDKNGTQF TFDSWNYSFE DNYSYELSSD YSLTPAAPCY SCNLLDRSSL PFFMLTSVLG MLASGSILFA ILRPFFHWQI CPSWPILAEL AVGSALFSIA VPILAPGLHS AHSTALCNLG YWVWYTSAFA QALLIGCYAC LNPRLNIGQL RGFTLGLSVG LWGAAALSGL PVALASDVYN GFCTFPSSRD MEALKYTHYA ICFTIFTVLP LTLLAAKGLK IALSKGPGPW VSVLWIWFIF WWPHGMVLIF DALVRSKTVL LYTCQSQKIL DAMLNVTEAL SMLHCVATPL LLALFCHQTT RRSLSSLSLP TRQASQMDAL AGKS // ID TLR1_DROME STANDARD; PRT; 504 AA. AC P30974; Q9VGX8; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 21-JUN-2005, sequence version 2. DT 18-APR-2006, entry version 50. DE Tachykinin-like peptides receptor 86C (NKD). GN Name=Takr86C; Synonyms=NKD; ORFNames=CG6515; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Head; RX MEDLINE=92112776; PubMed=1370464; RA Monnier D., Colas J.-F., Rosay P., Hen R., Borrelli E., Maroteaux L.; RT "NKD, a developmentally regulated tachykinin receptor in Drosophila."; RL J. Biol. Chem. 267:1298-1302(1992). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP NUCLEOTIDE SEQUENCE OF 1-60. RX MEDLINE=96028533; PubMed=7547478; DOI=10.1016/0925-4773(95)00382-7; RA Rosay P., Colas J.-F., Maroteaux L.; RT "Dual organisation of the Drosophila neuropeptide receptor NKD gene RT promoter."; RL Mech. Dev. 51:329-339(1995). CC -!- FUNCTION: May play a role in neurogenesis. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Central nervous system, as well as in subsets CC of neurons in each segment of the developing ventral ganglia. CC -!- DEVELOPMENTAL STAGE: During the development and in the adult. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M77168; AAA28722.1; -; mRNA. DR EMBL; AE003688; AAF54544.1; -; Genomic_DNA. DR EMBL; S80427; AAB35334.2; -; Genomic_DNA. DR UniGene; Dm.2452; -. DR HSSP; P02699; 1BOJ. DR Ensembl; CG6515; Drosophila melanogaster. DR FlyBase; FBgn0004841; Takr86C. DR GO; GO:0004995; F:tachykinin receptor activity; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001681; Neurokn_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00244; NEUROKININR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 504 Tachykinin-like peptides receptor 86C. FT /FTId=PRO_0000070184. FT TOPO_DOM 1 84 Extracellular (Potential). FT TRANSMEM 85 108 1 (Potential). FT TOPO_DOM 109 118 Cytoplasmic (Potential). FT TRANSMEM 119 143 2 (Potential). FT TOPO_DOM 144 155 Extracellular (Potential). FT TRANSMEM 156 179 3 (Potential). FT TOPO_DOM 180 199 Cytoplasmic (Potential). FT TRANSMEM 200 224 4 (Potential). FT TOPO_DOM 225 250 Extracellular (Potential). FT TRANSMEM 251 275 5 (Potential). FT TOPO_DOM 276 308 Cytoplasmic (Potential). FT TRANSMEM 309 330 6 (Potential). FT TOPO_DOM 331 343 Extracellular (Potential). FT TRANSMEM 344 367 7 (Potential). FT TOPO_DOM 368 504 Cytoplasmic (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CONFLICT 187 187 H -> D (in Ref. 1). FT CONFLICT 226 226 H -> Q (in Ref. 1). FT CONFLICT 263 263 Y -> T (in Ref. 1). FT CONFLICT 281 282 LW -> PG (in Ref. 1). SQ SEQUENCE 504 AA; 58020 MW; 723C9622F3B663B9 CRC64; MSEIVDTELL VNCTILAVRR FELNSIVNTT LLGSLNRTEV VSLLSSIIDN RDNLESINEA KDFLTECLFP SPTRPYELPW EQKTIWAIIF GLMMFVAIAG NGIVLWIVTG HRSMRTVTNY FLLNLSIADL LMSSLNCVFN FIFMLNSDWP FGSIYCTINN FVANVTVSTS VFTLVAISFD RYIAIVHPLK RRTSRRKVRI ILVLIWALSC VLSAPCLLYS SIMTKHYYNG KSRTVCFMMW PDGRYPTSMA DYAYNLIILV LTYGIPMIVM LICYSLMGRV LWGSRSIGEN TDRQMESMKS KRKVVRMFIA IVSIFAICWL PYHLFFIYAY HNNQVASTKY VQHMYLGFYW LAMSNAMVNP LIYYWMNKRF RMYFQRIICC CCVGLTRHRF DSPKSRLTNK NSSNRHTRAE TKSQWKRSTM ETQIQQAPVT SSCREQRSAQ QQQPPGSGTN RAAVECIMER PADGSSSPLC LSINNSIGER QRVKIKYISC DEDNNPVELS PKQM // ID CAPAR_DROME STANDARD; PRT; 477 AA. AC Q8ITC7; Q9VP15; DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 07-FEB-2006, sequence version 3. DT 04-APR-2006, entry version 28. DE Neuropeptides capa receptor (Cap2b receptor). GN Name=capaR; ORFNames=CG14575; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION. RC STRAIN=Canton-S; RX MEDLINE=22177201; PubMed=12177421; DOI=10.1073/pnas.162276199; RA Park Y., Kim Y.-J., Adams M.E.; RT "Identification of G protein-coupled receptors for Drosophila PRXamide RT peptides, CCAP, corazonin, and AKH supports a theory of ligand- RT receptor coevolution."; RL Proc. Natl. Acad. Sci. U.S.A. 99:11423-11428(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND RP DEVELOPMENTAL STAGE. RX MEDLINE=22347021; PubMed=12459185; DOI=10.1016/S0006-291X(02)02709-2; RA Iversen A., Cazzamali G., Williamson M., Hauser F., RA Grimmelikhuijzen C.J.P.; RT "Molecular cloning and functional expression of a Drosophila receptor RT for the neuropeptides capa-1 and -2."; RL Biochem. Biophys. Res. Commun. 299:628-633(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- FUNCTION: Acts as a receptor for the neuropeptides CAP-1 and CAP- CC 2, but not CAP-3. Probably a component of signal transduction CC pathway that leads to Malpighian tubule fluid secretion in CC response to these ligands. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein CC (Potential). CC -!- TISSUE SPECIFICITY: In adults, expression in thorax and/or CC abdomen. CC -!- DEVELOPMENTAL STAGE: Expressed weakly in 16-24 hours embryos and CC second instar larvae and strongly in first and third instar larvae CC and adults. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF522193; AAN10046.1; -; mRNA. DR EMBL; AF505865; AAO20968.1; -; mRNA. DR EMBL; AE003594; AAS65092.1; -; Genomic_DNA. DR UniGene; Dm.15070; -. DR Ensembl; CG14575; Drosophila melanogaster. DR FlyBase; FBgn0037100; capaR. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0008188; F:neuropeptide receptor activity; IDA. DR GO; GO:0007589; P:fluid secretion; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 477 Neuropeptides capa receptor. FT /FTId=PRO_0000069217. FT TOPO_DOM 1 72 Extracellular (Potential). FT TRANSMEM 73 93 1 (Potential). FT TOPO_DOM 94 109 Cytoplasmic (Potential). FT TRANSMEM 110 130 2 (Potential). FT TOPO_DOM 131 145 Extracellular (Potential). FT TRANSMEM 146 166 3 (Potential). FT TOPO_DOM 167 189 Cytoplasmic (Potential). FT TRANSMEM 190 210 4 (Potential). FT TOPO_DOM 211 237 Extracellular (Potential). FT TRANSMEM 238 258 5 (Potential). FT TOPO_DOM 259 295 Cytoplasmic (Potential). FT TRANSMEM 296 316 6 (Potential). FT TOPO_DOM 317 335 Extracellular (Potential). FT TRANSMEM 336 356 7 (Potential). FT TOPO_DOM 357 447 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT DISULFID 142 228 By similarity. SQ SEQUENCE 477 AA; 54005 MW; 34FFB13F301A9F4D CRC64; MNSSTDPTFS ELNASFTNTP DTLFATSVSS DPSHGFGEED YACGTFNCSP KEFVAFVLGP QTLPLYKAVL ITIIFGGIFI TGVVGNLLVC IVIIRHSAMH TATNYYLFSL AVSDLLYLLF GLPTEVFLYW HQYPDLFGMP FCKIRAFISE ACTYVSVFTI VAFSMERFLA ICHPLHLYAM VGFKRAIRII TALWIVSFIS AIPFGLLSDI QYLNYPLDHS RIEESAFCSM SPKIVNEIPV FEVSFCIFFV IPMILIILLY GRMGAKIRSR TNQKLGVQQG TNNRETRNSQ MRKKTVIRML AAVVITFFVC WFPFHLQRLI FLYAKNMDNY LDINEALFSI AGFAYYVSCT VNPIVYSVMS RRYRVAFREL LCGKAVGAYY NSGFARDHSS FRESSAYDRV HSVHVRASQH PNKFETDSSS ANRVLIKKTY SLPLPKNADS TVLSTTDIVI VLENSHTVCE EPKVENDIWI ENEETCI // ID GPR83_CANFA STANDARD; PRT; 422 AA. AC Q9TTQ9; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 02-MAY-2006, entry version 35. DE Probable G-protein coupled receptor 83 precursor (Glucocorticoid- DE induced receptor). GN Name=GPR83; Synonyms=GIR, GPR72; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Thyroid; RA Perret J., Simons M., De Moerlooze L., Parmentier M.; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Orphan receptor. Could be a neuropeptide y receptor. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y19224; CAB57795.1; -; mRNA. DR UniGene; Cfa.3560; -. DR Ensembl; ENSCAFG00000004171; Canis familiaris. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000611; NPY_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01012; NRPEPTIDEYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Signal; KW Transducer; Transmembrane. FT SIGNAL 1 16 Potential. FT CHAIN 17 422 Probable G-protein coupled receptor 83. FT /FTId=PRO_0000012802. FT TOPO_DOM 17 70 Extracellular (Potential). FT TRANSMEM 71 91 1 (Potential). FT TOPO_DOM 92 106 Cytoplasmic (Potential). FT TRANSMEM 107 128 2 (Potential). FT TOPO_DOM 129 144 Extracellular (Potential). FT TRANSMEM 145 166 3 (Potential). FT TOPO_DOM 167 185 Cytoplasmic (Potential). FT TRANSMEM 186 207 4 (Potential). FT TOPO_DOM 208 237 Extracellular (Potential). FT TRANSMEM 238 259 5 (Potential). FT TOPO_DOM 260 292 Cytoplasmic (Potential). FT TRANSMEM 293 314 6 (Potential). FT TOPO_DOM 315 326 Extracellular (Potential). FT TRANSMEM 327 347 7 (Potential). FT TOPO_DOM 348 422 Cytoplasmic (Potential). FT CARBOHYD 37 37 N-linked (GlcNAc...) (Potential). FT CARBOHYD 45 45 N-linked (GlcNAc...) (Potential). FT CARBOHYD 133 133 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 422 AA; 48043 MW; C9C21DE85B9DFB67 CRC64; MGRRGALLCL LPLLRAAERP EGRADEPGLE AALAGPNASH FFWSNYSFSD WQNFVGRRRY GAESQNPTVK ALLVVAYSFI IVFSLFGNVL VCHVIFKNQR MRSATSLFIV NLAVADILIT LLNTPFTLVR FVNSTWVFGK GMCHVSRFAQ YCSLHVSALT LTAIAVDRHQ VIMHPLKPRI SITKGVIYIT VIWTMATFFS LPHAICQKLF TFKYSEDIVR SLCLPDFPEP ADLFWKYLDL ATFILLYILP LLIISVAYAR VAKKLWLCNT IGDVTTEQYL ALRRKKKKTI KMLMLVVVLF ALCWFPLNCY VLLLSSKVIH TNNALYFAFH WFAMSSTCYN PFIYCWLNEN FRIELKALLS MCQRLPKPQE ERPPSPVPSF RVAWTEKSNG RRVPPANNLL LSSHLHSGKT DLSSVEPIVA MS // ID NPY5R_CANFA STANDARD; PRT; 446 AA. AC O62729; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 02-MAY-2006, entry version 39. DE Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (Y5 DE receptor) (NPYY5). GN Name=NPY5R; Synonyms=NPY5; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=99017379; PubMed=9802393; DOI=10.1016/S0167-0115(98)00052-4; RA Borowsky B., Walker M.W., Bard J., Weinshank R.L., Laz T.M., RA Vaysse P., Branchek T.A., Gerald C.; RT "Molecular biology and pharmacology of multiple NPY Y5 receptor RT species homologs."; RL Regul. Pept. 75:45-53(1998). CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity CC of this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. Seems to be associated with food intake. Could CC be involved in feeding disorders (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF049328; AAC17838.1; -; mRNA. DR UniGene; Cfa.3575; -. DR Ensembl; ENSCAFG00000008794; Canis familiaris. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000393; NPY5_rcpt. DR InterPro; IPR000611; NPY_rcpt. DR PANTHER; PTHR19264:SF83; NPY5_receptor; 2. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01016; NRPEPTIDEY5R. DR PRINTS; PR01012; NRPEPTIDEYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 446 Neuropeptide Y receptor type 5. FT /FTId=PRO_0000069938. FT TOPO_DOM 1 40 Extracellular (Potential). FT TRANSMEM 41 62 1 (Potential). FT TOPO_DOM 63 74 Cytoplasmic (Potential). FT TRANSMEM 75 95 2 (Potential). FT TOPO_DOM 96 115 Extracellular (Potential). FT TRANSMEM 116 137 3 (Potential). FT TOPO_DOM 138 157 Cytoplasmic (Potential). FT TRANSMEM 158 178 4 (Potential). FT TOPO_DOM 179 210 Extracellular (Potential). FT TRANSMEM 211 232 5 (Potential). FT TOPO_DOM 233 368 Cytoplasmic (Potential). FT TRANSMEM 369 391 6 (Potential). FT TOPO_DOM 392 404 Extracellular (Potential). FT TRANSMEM 405 428 7 (Potential). FT TOPO_DOM 429 446 Cytoplasmic (Potential). FT LIPID 442 442 S-palmitoyl cysteine (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 114 198 By similarity. SQ SEQUENCE 446 AA; 51013 MW; 5CAC8D2FCF5D254A CRC64; MDLELQDFYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF VSLLGFMGNL LILMALMRKR NQKTMVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELQETFDSA LLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSNKENKLE ENEMINLTLQ PFKKSGPQVK LSSSHKWSYS FIRKHRRRYS KKTACVLPAP ARPPQENHSR MLPENFGSVR SQHSSSSKFI PGVPTCFEVK PEENSDVHDM RVNRSIMRIK KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLISLI QCLHMS // ID UR2R_HUMAN STANDARD; PRT; 389 AA. AC Q9UKP6; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 18-APR-2006, entry version 40. DE Urotensin II receptor (UR-II-R) (G-protein coupled receptor 14). GN Name=UTS2R; Synonyms=GPR14; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=99427933; PubMed=10499587; DOI=10.1038/45809; RA Ames R.S., Sarau H.M., Chambers J.K., Willette R.N., Aiyar N.V., RA Romanic A.M., Louden C.S., Foley J.J., Sauermelch C.F., Coatney R.W., RA Ao Z., Disa J., Holmes S.D., Stadel J.M., Martin J.D., Liu W.-S., RA Glover G.I., Wilson S., McNulty D.E., Ellis C.E., Elshourbagy N.A., RA Shabon U., Trill J.J., Hay D.W.P., Ohlstein E.H., Bergsma D.J., RA Douglas S.A.; RT "Human urotensin-II is a potent vasoconstrictor and agonist for the RT orphan receptor GPR14."; RL Nature 401:282-286(1999). RN [2] RP FUNCTION AS A UROTENSIN-2B RECEPTOR. RX MEDLINE=22898141; PubMed=14550283; DOI=10.1016/j.bbrc.2003.09.102; RA Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y., RA Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.; RT "Identification of urotensin II-related peptide as the urotensin II- RT immunoreactive molecule in the rat brain."; RL Biochem. Biophys. Res. Commun. 310:860-868(2003). CC -!- FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. CC The activity of this receptor is mediated by a G-protein that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Most abundant expression in the heart and CC pancreas. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF140631; AAD55578.1; -; Genomic_DNA. DR UniGene; Hs.192720; -. DR Ensembl; ENSG00000181408; Homo sapiens. DR HGNC; HGNC:4468; UTS2R. DR MIM; 600896; gene. DR GO; GO:0016020; C:membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0008015; P:circulation; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000670; Urot_II_rcpt. DR PANTHER; PTHR19264:SF112; UrotII_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00647; UROTENSIN2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 389 Urotensin II receptor. FT /FTId=PRO_0000070193. FT TOPO_DOM 1 54 Extracellular (Potential). FT TRANSMEM 55 77 1 (Potential). FT TOPO_DOM 78 87 Cytoplasmic (Potential). FT TRANSMEM 88 113 2 (Potential). FT TOPO_DOM 114 124 Extracellular (Potential). FT TRANSMEM 125 146 3 (Potential). FT TOPO_DOM 147 167 Cytoplasmic (Potential). FT TRANSMEM 168 186 4 (Potential). FT TOPO_DOM 187 209 Extracellular (Potential). FT TRANSMEM 210 232 5 (Potential). FT TOPO_DOM 233 258 Cytoplasmic (Potential). FT TRANSMEM 259 284 6 (Potential). FT TOPO_DOM 285 297 Extracellular (Potential). FT TRANSMEM 298 318 7 (Potential). FT TOPO_DOM 319 389 Cytoplasmic (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT DISULFID 123 199 By similarity. SQ SEQUENCE 389 AA; 42130 MW; 6D6A88DBF78400CE CRC64; MALTPESPSS FPGLAATGSS VPEPPGGPNA TLNSSWASPT EPSSLEDLVA TGTIGTLLSA MGVVGVVGNA YTLVVTCRSL RAVASMYVYV VNLALADLLY LLSIPFIVAT YVTKEWHFGD VGCRVLFGLD FLTMHASIFT LTVMSSERYA AVLRPLDTVQ RPKGYRKLLA LGTWLLALLL TLPVMLAMRL VRRGPKSLCL PAWGPRAHRA YLTLLFATSI AGPGLLIGLL YARLARAYRR SQRASFKRAR RPGARALRLV LGIVLLFWAC FLPFWLWQLL AQYHQAPLAP RTARIVNYLT TCLTYGNSCA NPFLYTLLTR NYRDHLRGRV RGPGSGGGRG PVPSLQPRAR FQRCSGRSLS SCSPQPTDSL VLAPAAPARP APEGPRAPA // ID NPYR_DROME STANDARD; PRT; 464 AA. AC P25931; Q9VB87; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 31-AUG-2004, sequence version 2. DT 04-APR-2006, entry version 46. DE Neuropeptide Y receptor (NPY-R) (PR4 receptor). GN Name=NepYr; ORFNames=CG5811; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE OF 9-464, FUNCTION, AND DEVELOPMENTAL STAGE. RC STRAIN=Canton-S; TISSUE=Head; RX MEDLINE=92112730; PubMed=1370455; RA Li X.-J., Wu Y.-N., North R.A., Forte M.A.; RT "Cloning, functional expression, and developmental regulation of a RT neuropeptide Y receptor from Drosophila melanogaster."; RL J. Biol. Chem. 267:9-12(1992). CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- DEVELOPMENTAL STAGE: At low levels during early embryonic stages, CC its expression increases later and reaches the highest level CC during late stages of embryogenesis. Subsequently, PR4 levels are CC reduced during larval stages and increase during pupal stages. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AE003759; AAF56655.3; -; Genomic_DNA. DR EMBL; M81490; AAA28727.1; ALT_INIT; mRNA. DR PIR; A41738; A41738. DR UniGene; Dm.2344; -. DR Ensembl; CG5811; Drosophila melanogaster. DR FlyBase; FBgn0004842; NepYr. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000611; NPY_rcpt. DR InterPro; IPR002885; PPR. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01012; NRPEPTIDEYR. DR TIGRFAMs; TIGR00756; PPR; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 464 Neuropeptide Y receptor. FT /FTId=PRO_0000069945. FT TOPO_DOM 1 105 Extracellular (Potential). FT TRANSMEM 106 126 1 (Potential). FT TOPO_DOM 127 148 Cytoplasmic (Potential). FT TRANSMEM 149 169 2 (Potential). FT TOPO_DOM 170 189 Extracellular (Potential). FT TRANSMEM 190 210 3 (Potential). FT TOPO_DOM 211 221 Cytoplasmic (Potential). FT TRANSMEM 222 242 4 (Potential). FT TOPO_DOM 243 274 Extracellular (Potential). FT TRANSMEM 275 295 5 (Potential). FT TOPO_DOM 296 329 Cytoplasmic (Potential). FT TRANSMEM 330 350 6 (Potential). FT TOPO_DOM 351 363 Extracellular (Potential). FT TRANSMEM 364 384 7 (Potential). FT TOPO_DOM 385 464 Cytoplasmic (Potential). FT CARBOHYD 49 49 N-linked (GlcNAc...) (Potential). FT CARBOHYD 79 79 N-linked (GlcNAc...) (Potential). FT CARBOHYD 85 85 N-linked (GlcNAc...) (Potential). FT CARBOHYD 183 183 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 464 AA; 53524 MW; CA8DBC202259BBFF CRC64; MEHHNSHLLP GGSEKMYYIA HQQPMLRNED DNYQEGYFIR PDPASLIYNT TALPADDEGS NYGYGSTTTL SGLQFETYNI TVMMNFSCDD YDLLSEDMWS SAYFKIIVYM LYIPIFIFAL IGNGTVCYIV YSTPRMRTVT NYFIASLAIG DILMSFFCVP SSFISLFILN YWPFGLALCH FVNYSQAVSV LVSAYTLVAI SIDRYIAIMW PLKPRITKRY ATFIIAGVWF IALATALPIP IVSGLDIPMS PWHTKCEKYI CREMWPSRTQ EYYYTLSLFA LQFVVPLGVL IFTYARITIR VWAKRPPGEA ETNRDQRMAR SKRKMVKMML TVVIVFTCCW LPFNILQLLL NDEEFAHWDP LPYVWFAFHW LAMSHCCYNP IIYCYMNARF RSGFVQLMHR MPGLRRWCCL RSVGDRMNAT SGTGPALPLN RMNTSTTYIS ARRKPRATSL RANPLSCGET SPLR // ID CML2_MOUSE STANDARD; PRT; 375 AA. AC Q8BMP4; Q9D392; DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 02-MAY-2006, entry version 24. DE Chemokine receptor-like 2 (G-protein coupled receptor 30). GN Name=Gpr30; Synonyms=Cmkrl2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Pituitary; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). CC -!- FUNCTION: Orphan receptor; possibly for a chemokine. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AK018203; BAB31118.1; -; mRNA. DR EMBL; AK030375; BAC26930.1; -; mRNA. DR UniGene; Mm.383252; -. DR Ensembl; ENSMUSG00000053647; Mus musculus. DR MGI; MGI:1924104; Gpr30. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR002286; P2_purnocptor. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01157; P2YPURNOCPTR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 375 Chemokine receptor-like 2. FT /FTId=PRO_0000069311. FT TOPO_DOM 1 62 Extracellular (Potential). FT TRANSMEM 63 84 1 (Potential). FT TOPO_DOM 85 96 Cytoplasmic (Potential). FT TRANSMEM 97 120 2 (Potential). FT TOPO_DOM 121 132 Extracellular (Potential). FT TRANSMEM 133 153 3 (Potential). FT TOPO_DOM 154 175 Cytoplasmic (Potential). FT TRANSMEM 176 194 4 (Potential). FT TOPO_DOM 195 220 Extracellular (Potential). FT TRANSMEM 221 236 5 (Potential). FT TOPO_DOM 237 259 Cytoplasmic (Potential). FT TRANSMEM 260 280 6 (Potential). FT TOPO_DOM 281 306 Extracellular (Potential). FT TRANSMEM 307 327 7 (Potential). FT TOPO_DOM 328 375 Cytoplasmic (Potential). FT CARBOHYD 32 32 N-linked (GlcNAc...) (Potential). FT CARBOHYD 44 44 N-linked (GlcNAc...) (Potential). FT DISULFID 130 207 Potential. FT CONFLICT 314 314 I -> F (in Ref. 1; BAB31118). FT CONFLICT 369 369 V -> I (in Ref. 1; BAB31118). SQ SEQUENCE 375 AA; 42445 MW; A6E7D795C3A6AB05 CRC64; MDATTPAQTV GVEIYLGPVW PAPSNSTPLA LNLSLALRED APGNLTGDLS EHQQYVIALF LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN LAAADLILVA DSLIEVFNLD EQYYDIAVLC TFMSLFLQIN MYSSVFFLTW MSFDRYLALA KAMRCGLFRT KHHARLSCGL IWMASVSATL VPFTAVHLRH TEEACFCFAD VREVQWLEVT LGFIMPFAII GLCYSLIVRA LIRAHRHRGL RPRRQKALRM IFAVVLVFFI CWLPENVFIS VHLLQWTQPG DTPCKQSFRH AYPLTGHIVN LAAISNSCLN PLIYSFLGET FRDKLRLYVE QKTSLPALNR FCHATLKAVI PDSTEQSEVR FSSAV //