ID MC5R_BOVIN STANDARD; PRT; 325 AA. AC P56451; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 1. DT 04-APR-2006, entry version 34. DE Melanocortin receptor 5 (MC5-R). GN Name=MC5R; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Oulmouden A., Petit J.M., Julien R.; RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The CC activity of this receptor is mediated by G proteins which activate CC adenylate cyclase. This receptor is a possible mediator of the CC immunomodulation properties of melanocortins (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AJ002024; CAA05147.1; -; Genomic_DNA. DR UniGene; Bt.45037; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001908; Melancort_rcpt. DR InterPro; IPR000621; Melancort_rcpt_5. DR InterPro; IPR001671; Melcrt_ACTH_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00535; MELNOCORTINR. DR PRINTS; PR01063; MELNOCORTN5R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 325 Melanocortin receptor 5. FT /FTId=PRO_0000069727. FT TOPO_DOM 1 37 Extracellular (Potential). FT TRANSMEM 38 61 1 (Potential). FT TOPO_DOM 62 73 Cytoplasmic (Potential). FT TRANSMEM 74 97 2 (Potential). FT TOPO_DOM 98 114 Extracellular (Potential). FT TRANSMEM 115 138 3 (Potential). FT TOPO_DOM 139 155 Cytoplasmic (Potential). FT TRANSMEM 156 179 4 (Potential). FT TOPO_DOM 180 186 Extracellular (Potential). FT TRANSMEM 187 211 5 (Potential). FT TOPO_DOM 212 239 Cytoplasmic (Potential). FT TRANSMEM 240 265 6 (Potential). FT TOPO_DOM 266 273 Extracellular (Potential). FT TRANSMEM 274 297 7 (Potential). FT TOPO_DOM 298 325 Cytoplasmic (Potential). FT LIPID 311 311 S-palmitoyl cysteine (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 325 AA; 36526 MW; 81B6ACB2F12A09C7 CRC64; MNSSFHLHFL DLGLNTTDGN LSGLSVQNAS SLCEDMGIAV EVFLALGLIS LLENILVIGA IVRNRNLHTP MYFFVGSLAV ADMLVSLSNS WETITIYLLT NKHLVMADAS VRHLDNVFDS MICISVVASM CSLLAIAVDR YVTIFCALRY QRIMTGRRSG AIIGGIWAFC ASCGTVFIVY YESTYVVICL IAMFLTMLLL MASLYTHMFL LARTHIRRIA TLPGHSSVRQ RTGVKGAITL AMLLGVFIVC WAPFFLHLIL MISCPHNLYC SCFMSHFNMY LILIMCNSVI DPLIYAFRSQ EMRKTFKEIV CFQSFRTPCR FPSRY // ID MSHR_CEREL STANDARD; PRT; 317 AA. AC P56445; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 1. DT 07-MAR-2006, entry version 37. DE Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin DE receptor) (Melanocortin receptor 1) (MC1-R). GN Name=MC1R; Synonyms=MSHR; OS Cervus elaphus (Red deer). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Cervidae; Cervinae; Cervus. OX NCBI_TaxID=9860; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=20093783; PubMed=10628296; RA Klungland H., Roed K.H., Nesbo C.L., Jakobsen K.S., Vage D.I.; RT "The melanocyte-stimulating hormone receptor (MC1-R) gene as a tool in RT evolutionary studies of artiodactyles."; RL Hereditas 131:39-46(1999). CC -!- FUNCTION: Receptor for MSH (alpha, beta) and ACTH. Does not seem CC to be active with gamma-MSH. The activity of this receptor is CC mediated by G proteins which activate adenylate cyclase. Could be CC involved in spermatogenesis. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y13962; CAA74296.1; -; Genomic_DNA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Melcrt_ACTH_rcpt. DR InterPro; IPR000761; MSH_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PRINTS; PR00536; MELNOCYTESHR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 317 Melanocyte-stimulating hormone receptor. FT /FTId=PRO_0000069805. FT TOPO_DOM 1 37 Extracellular (Potential). FT TRANSMEM 38 63 1 (Potential). FT TOPO_DOM 64 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT TOPO_DOM 94 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT TOPO_DOM 141 163 Cytoplasmic (Potential). FT TRANSMEM 164 183 4 (Potential). FT TOPO_DOM 184 191 Extracellular (Potential). FT TRANSMEM 192 211 5 (Potential). FT TOPO_DOM 212 240 Cytoplasmic (Potential). FT TRANSMEM 241 266 6 (Potential). FT TOPO_DOM 267 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT TOPO_DOM 301 317 Cytoplasmic (Potential). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 317 AA; 34914 MW; DB55ADD7331D3E7E CRC64; MPVLGSQRRL LGSLNCTPPA TFPLTLAPNR TGPQCLEVAI PDGLFLSLGL VSLVENVLVV AAIAKNRNLQ SPMYYFICCL AMSDLLVSVS NVLETAVMLL LEAGALAARA AVVQQLDNVI DVLICGSMVS SLCFLGAIAV DRYISIFYAL RYHSVVTLPR AWRIIAAIWV ASILTSLLFI TYYNHTVVLL CLVGFFIAML ALMAVLYVHM LARACQHARG IARLQKRQRP IHQGFGLKGA ATLTILLGVF FLCWGPFFLH LSLIVLCPQH PTCGCIFKNF NLFLALIICN AIVDPLIYAF RSQELRKTLQ EVLQCSW // ID ACTHR_BOVIN STANDARD; PRT; 297 AA. AC P34974; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 04-APR-2006, entry version 45. DE Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) DE (Melanocortin receptor 2) (MC2-R) (Adrenocorticotropin receptor). GN Name=MC2R; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Cone R.D., Mountjoy K.G.; RT "Molecular genetics of the ACTH and melanocyte-stimulating hormone RT receptors."; RL Trends Endocrinol. Metab. 4:26-31(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Adrenal cortex; RX MEDLINE=94137797; PubMed=8305507; DOI=10.1016/0167-4889(94)90157-0; RA Raikhinstein M., Zohar M., Hanukoglu I.; RT "cDNA cloning and sequence analysis of the bovine adrenocorticotropic RT hormone (ACTH) receptor."; RL Biochim. Biophys. Acta 1220:329-332(1994). CC -!- FUNCTION: Receptor for ACTH. This receptor is mediated by G CC proteins which activate adenylate cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Melanocytes and corticoadrenal tissue. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L23149; AAA30355.1; -; mRNA. DR EMBL; X74501; CAA52610.1; -; mRNA. DR PIR; I45849; I45849. DR PIR; S42767; S42767. DR UniGene; Bt.3956; -. DR InterPro; IPR001168; ACTH_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Melcrt_ACTH_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00520; ACTROPHINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 297 Adrenocorticotropic hormone receptor. FT /FTId=PRO_0000069052. FT TOPO_DOM 1 23 Extracellular (Potential). FT TRANSMEM 24 49 1 (Potential). FT TOPO_DOM 50 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT TOPO_DOM 80 104 Extracellular (Potential). FT TRANSMEM 105 126 3 (Potential). FT TOPO_DOM 127 147 Cytoplasmic (Potential). FT TRANSMEM 148 168 4 (Potential). FT TOPO_DOM 169 180 Extracellular (Potential). FT TRANSMEM 181 199 5 (Potential). FT TOPO_DOM 200 217 Cytoplasmic (Potential). FT TRANSMEM 218 244 6 (Potential). FT TOPO_DOM 245 256 Extracellular (Potential). FT TRANSMEM 257 278 7 (Potential). FT TOPO_DOM 279 297 Cytoplasmic (Potential). FT LIPID 293 293 S-palmitoyl cysteine (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CONFLICT 145 150 HRALVI -> APCPRH (in Ref. 1). FT CONFLICT 278 278 F -> L (in Ref. 2). SQ SEQUENCE 297 AA; 33293 MW; 8B77A8C2E268BB1E CRC64; MKHILNLYEN INSTARNNSD CPAVILPEEI FFTVSIVGVL ENLMVLLAVA KNKSLQSPMY FFICSLAISD MLGSLYKILE NVLIMFKNMG YLEPRGSFES TADDVVDSLF ILSLLGSICS LSVIAADRYI TIFHALQYHR IMTPHRALVI LTVLWAGCTG SGITIVTFSH HVPTVIAFTA LFPLMLAFIL CLYVHMFLLA RSHTRRTPSL PKANMRGAVT LTVLLGVFIF CWAPFVLHVL LMTFCPADPY CACYMSLFQV NGVLIMCNAI IDPFIYAFRS PELRVAFKKM VICNCYQ // ID BRS4_BOMOR STANDARD; PRT; 392 AA. AC P47751; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 2. DT 07-MAR-2006, entry version 36. DE [Phe13]bombesin receptor (Bombesin receptor subtype-4) (BRS-4). GN Name=BB4; OS Bombina orientalis (Oriental fire-bellied toad). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Archeobatrachia; Bombinatoridae; Bombina. OX NCBI_TaxID=8346; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=95320240; PubMed=7597102; RA Nagalla S.R., Barry B.J., Creswick K.C., Eden P., Taylor J.T., RA Spindel E.R.; RT "Cloning of a receptor for amphibian [Phe13]bombesin distinct from the RT receptor for gastrin-releasing peptide: identification of a fourth RT bombesin receptor subtype (BB4)."; RL Proc. Natl. Acad. Sci. U.S.A. 92:6205-6209(1995). RN [2] RP SEQUENCE REVISION TO C-TERMINUS. RA Spindel E.R.; RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The relative rank potency of bombesin-like peptides for CC this receptor is [Phe13]bombesin > [Leu13]bombesin > GRP > CC neuromedin B. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed only in brain, primarily in cortex CC and forebrain and at low levels in the midbrain. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L39358; AAA91102.1; -; mRNA. DR InterPro; IPR000401; Bombesin_rcpt_4. DR InterPro; IPR001556; Bombsn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF59; Bmbsn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00638; BOMBESIN4R. DR PRINTS; PR00358; BOMBESINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 392 [Phe13]bombesin receptor. FT /FTId=PRO_0000069200. FT TOPO_DOM 1 40 Extracellular (Potential). FT TRANSMEM 41 62 1 (Potential). FT TOPO_DOM 63 81 Cytoplasmic (Potential). FT TRANSMEM 82 102 2 (Potential). FT TOPO_DOM 103 120 Extracellular (Potential). FT TRANSMEM 121 142 3 (Potential). FT TOPO_DOM 143 162 Cytoplasmic (Potential). FT TRANSMEM 163 183 4 (Potential). FT TOPO_DOM 184 219 Extracellular (Potential). FT TRANSMEM 220 240 5 (Potential). FT TOPO_DOM 241 271 Cytoplasmic (Potential). FT TRANSMEM 272 292 6 (Potential). FT TOPO_DOM 293 312 Extracellular (Potential). FT TRANSMEM 313 332 7 (Potential). FT TOPO_DOM 333 392 Cytoplasmic (Potential). FT LIPID 346 346 S-palmitoyl cysteine (By similarity). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT DISULFID 119 202 By similarity. SQ SEQUENCE 392 AA; 43462 MW; 497C620209F1DBEB CRC64; MPEGFQSLNQ TLPSAISSIA HLESLNDSFI LGAKQSEDVS PGLEILALIS VTYAVIISVG ILGNTILIKV FFKIKSMQTV PNIFITSLAF GDLLLLLTCV PVDASRYIVD TWMFGRAGCK IISFIQLTSV GVSVFTLTVL SADRYRAIVK PLQLQTSDAV LKTCGKAVCV WIISMLLAAP EAVFSDLYEF GSSEKNTTFE ACAPYPVSEK ILQETHSLIC FLVFYIVPLS IISAYYFLIA KTLYKSTFNM PAEEHTHARK QIESRKRVAK TVLVLVALFA VCWLPNHMLY LYRSFTYHSA VNSSAFHLSA TIFARVLAFS NSCVNPFALY WLSRSFRQHF KKQVYCCKTE PPASQQSPTH SSTITGITAV KGNIQMSEIS ITLLSAYDVK KE // ID NMBR_MOUSE STANDARD; PRT; 390 AA. AC O54799; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1998, sequence version 1. DT 18-APR-2006, entry version 39. DE Neuromedin-B receptor (NMB-R) (Neuromedin-B-preferring bombesin DE receptor). GN Name=Nmbr; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; TISSUE=Liver; RX MEDLINE=97404084; PubMed=9262170; DOI=10.1016/S0006-8993(97)00380-6; RA Ohki-Hamazaki H., Wada E., Matsui K., Wada K.; RT "Cloning and expression of the neuromedin B receptor and the third RT subtype of bombesin receptor genes in the mouse."; RL Brain Res. 762:165-172(1997). CC -!- FUNCTION: Receptor for neuromedin-B. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB010281; BAA24405.1; -; Genomic_DNA. DR UniGene; Mm.259735; -. DR Ensembl; ENSMUSG00000019865; Mus musculus. DR MGI; MGI:1100525; Nmbr. DR InterPro; IPR001556; Bombsn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001642; NeuroB_rcpt. DR PANTHER; PTHR19264:SF59; Bmbsn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00358; BOMBESINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00639; NEUROMEDINBR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 390 Neuromedin-B receptor. FT /FTId=PRO_0000069904. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 65 1 (Potential). FT TOPO_DOM 66 79 Cytoplasmic (Potential). FT TRANSMEM 80 99 2 (Potential). FT TOPO_DOM 100 117 Extracellular (Potential). FT TRANSMEM 118 139 3 (Potential). FT TOPO_DOM 140 156 Cytoplasmic (Potential). FT TRANSMEM 157 177 4 (Potential). FT TOPO_DOM 178 211 Extracellular (Potential). FT TRANSMEM 212 235 5 (Potential). FT TOPO_DOM 236 266 Cytoplasmic (Potential). FT TRANSMEM 267 287 6 (Potential). FT TOPO_DOM 288 299 Extracellular (Potential). FT TRANSMEM 300 327 7 (Potential). FT TOPO_DOM 328 390 Cytoplasmic (Potential). FT LIPID 341 341 S-palmitoyl cysteine (By similarity). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). FT CARBOHYD 192 192 N-linked (GlcNAc...) (Potential). FT DISULFID 116 198 By similarity. SQ SEQUENCE 390 AA; 43623 MW; 2EA733B1DF108B42 CRC64; MPPRSLSNLS FPTEANESEL VPEVWEKDFL PDSDGTTAEL VIRCVIPSLY LIIISVGLLG NIMLVKIFLT NSAMRNVPNI FISNLAAGDL LLLLTCVPVD ASRYFFDEWV FGKLGCKLIP AIQLTSVGVS VFTLTALSAD RYRAIVNPMD MQTSGVLLWT SLKAVGIWVV SVLLAVPEAV FSEVARIGSL DNSSFTACIP YPQTDELHPK IHSVLIFLVY FLIPLVIISI YYYHIAKTLI KSAHNLPGEY NEHTKKQMET RKRLAKIVLV FVGCFVFCWF PNHVLYLYRS FNYKEIDPSL GHMIVTLVAR VLSFSNSCVN PFALYLLSES FRKHFNSQLC CGRKSYPERS TSYLLSSSAV RMTSLKSNTK NVVTNSVLLN GHSTKQEIAL // ID EDNRB_HORSE STANDARD; PRT; 443 AA. AC O62709; O77508; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2000, sequence version 2. DT 04-APR-2006, entry version 36. DE Endothelin B receptor precursor (ET-B) (Endothelin receptor Non- DE selective type). GN Name=EDNRB; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT OLWS LYS-126. RC TISSUE=Liver; RX MEDLINE=98248431; PubMed=9580670; DOI=10.1093/hmg/7.6.1047; RA Yang G.C., Croaker D., Zhang A.L., Manglick P., Cartmill T., Cass D.; RT "A dinucleotide mutation in the endothelin-B receptor gene is RT associated with lethal white foal syndrome (LWFS); a horse variant of RT Hirschsprung disease."; RL Hum. Mol. Genet. 7:1047-1052(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-443, AND VARIANT OLWS LYS-126. RX MEDLINE=98191732; PubMed=9530628; DOI=10.1007/s003359900754; RA Santschi E.M., Purdy A.K., Valberg S.J., Vrotsos P.D., Kaese H., RA Mickelson J.R.; RT "Endothelin receptor B polymorphism associated with lethal white foal RT syndrome in horses."; RL Mamm. Genome 9:306-309(1998). CC -!- FUNCTION: Non-specific receptor for endothelin 1, 2, and 3. CC Mediates its action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- DISEASE: Defects in EDNRB are a cause of overo lethal white CC syndrome (OLWS) also known as lethal white foal syndrome (LWFS). CC It is an inherited syndrome of foals born to American paint horse CC parents of the overo coat-pattern lineage. Affected foals are CC totally or almost totally white and die within days from CC complications due to intestinal aganglionosis. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF019072; AAC25983.1; -; mRNA. DR EMBL; AF038900; AAC23486.1; -; mRNA. DR InterPro; IPR000499; Endthln_rcpt. DR InterPro; IPR001112; ETB_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00571; ENDOTHELINBR. DR PRINTS; PR00366; ENDOTHELINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Disease mutation; G-protein coupled receptor; Glycoprotein; KW Lipoprotein; Membrane; Palmitate; Receptor; Signal; Transducer; KW Transmembrane. FT SIGNAL 1 26 Potential. FT CHAIN 27 443 Endothelin B receptor. FT /FTId=PRO_0000012728. FT TOPO_DOM 27 102 Extracellular (Potential). FT TRANSMEM 103 127 1 (Potential). FT TOPO_DOM 128 138 Cytoplasmic (Potential). FT TRANSMEM 139 164 2 (Potential). FT TOPO_DOM 165 176 Extracellular (Potential). FT TRANSMEM 177 198 3 (Potential). FT TOPO_DOM 199 219 Cytoplasmic (Potential). FT TRANSMEM 220 244 4 (Potential). FT TOPO_DOM 245 272 Extracellular (Potential). FT TRANSMEM 273 297 5 (Potential). FT TOPO_DOM 298 325 Cytoplasmic (Potential). FT TRANSMEM 326 351 6 (Potential). FT TOPO_DOM 352 363 Extracellular (Potential). FT TRANSMEM 364 390 7 (Potential). FT TOPO_DOM 391 443 Cytoplasmic (Potential). FT LIPID 403 403 S-palmitoyl cysteine (Potential). FT LIPID 404 404 S-palmitoyl cysteine (Potential). FT LIPID 406 406 S-palmitoyl cysteine (Potential). FT CARBOHYD 60 60 N-linked (GlcNAc...) (Potential). FT DISULFID 175 256 By similarity. FT VARIANT 126 126 I -> K (in OLWS). FT CONFLICT 11 11 V -> A (in Ref. 2). FT CONFLICT 43 44 FE -> SG (in Ref. 2). FT CONFLICT 64 66 PRL -> QRS (in Ref. 2). FT CONFLICT 79 79 A -> E (in Ref. 2). FT CONFLICT 92 92 E -> D (in Ref. 2). FT CONFLICT 297 297 E -> M (in Ref. 2). FT CONFLICT 369 369 E -> D (in Ref. 2). FT CONFLICT 400 400 W -> S (in Ref. 2). SQ SEQUENCE 443 AA; 50006 MW; 74381DDFCF9A9AF4 CRC64; MQPLPTLCGR VLVALILACG VAGVQGEERR FPPARATPPL LGFEEIMTPP TKTSWPTGSN ASVPRLSAPP QMPKAGRTAG AQRRTLPPPP CERTIEIKET FKYINTVVSC LVFVLGIIGN STLLRIIYKN KCMRNGPNIL IASLALGDLL HIIIDIPINV YKLLAEDWPF GVEMCKLVPF IQKASVGITV LSLCALSIDR YRAVASWSRI KGIGVPKWTA VEIVLIWVVS VVLAVPEAVG FDMITADYKG SYLRICLLHP TQKTAFMQFY KNAKDWWLFS FYFCLPLAIT AFFYTLETCE MLRKKSGMQI ALNDHLKQRR EVAKTVFCLV LVFALCWLPL HLSRILKHTL YDQNDPHRCE LLSFLLVLEY IGINMASLNS CINPIALYLV SKRFKNCFKW CLCCWCQSFE EKQSLEDKQS CLKFKANDHG YDNFRSSNKY SSS // ID ETBR2_MOUSE STANDARD; PRT; 481 AA. AC Q99JG2; O88313; Q80UB9; Q99JG1; DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 07-JUN-2005, sequence version 2. DT 18-APR-2006, entry version 28. DE Endothelin B receptor-like protein 2 precursor (ETBR-LP-2) (G-protein DE coupled receptor 37-like 1). GN Name=Gpr37l1; Synonyms=Etbrlp2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY. RC STRAIN=BALB/c; TISSUE=Liver; RA Marazziti D., Golini E., Magrelli A., Matteoni R., RA Tocchini-Valentini G.P.; RT "Genomic analysis of GPR37 and related orphan G-protein coupled RT receptor genes highly expressed in the mammalian brain."; RL Curr. Genomics 2:253-260(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 28-481. RC STRAIN=C57BL/6; TISSUE=Hippocampus; RA Matsuo N., Kawamoto S., Matsubara K., Okubo K.; RT "Cloning of a cDNA encoding a novel G-protein coupled receptor RT uniquely expressed in the adult brain."; RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-454. RX MEDLINE=22584407; PubMed=12679517; DOI=10.1073/pnas.0230374100; RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., RA Bergmann J.E., Gaitanaris G.A.; RT "The G protein-coupled receptor repertoires of human and mouse."; RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003). CC -!- FUNCTION: Orphan receptor (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein CC (Probable). CC -!- TISSUE SPECIFICITY: Highly expressed in brain. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AJ306537; CAC34842.1; -; Genomic_DNA. DR EMBL; AJ306538; CAC34843.1; -; Genomic_DNA. DR EMBL; AB016602; BAA32062.1; ALT_INIT; mRNA. DR EMBL; AY255561; AAO85073.1; -; mRNA. DR UniGene; Mm.272290; -. DR Ensembl; ENSMUSG00000026424; Mus musculus. DR MGI; MGI:1928503; Gpr37l1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003909; GPR37_rcpt. DR PANTHER; PTHR15279; GPR37_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01421; GPR37ORPHANR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Signal; KW Transducer; Transmembrane. FT SIGNAL 1 24 Potential. FT CHAIN 25 481 Endothelin B receptor-like protein 2. FT /FTId=PRO_0000012797. FT TOPO_DOM 25 134 Extracellular (Potential). FT TRANSMEM 135 155 1 (Potential). FT TOPO_DOM 156 167 Cytoplasmic (Potential). FT TRANSMEM 168 188 2 (Potential). FT TOPO_DOM 189 205 Extracellular (Potential). FT TRANSMEM 206 226 3 (Potential). FT TOPO_DOM 227 251 Cytoplasmic (Potential). FT TRANSMEM 252 272 4 (Potential). FT TOPO_DOM 273 310 Extracellular (Potential). FT TRANSMEM 311 331 5 (Potential). FT TOPO_DOM 332 360 Cytoplasmic (Potential). FT TRANSMEM 361 381 6 (Potential). FT TOPO_DOM 382 398 Extracellular (Potential). FT TRANSMEM 399 419 7 (Potential). FT TOPO_DOM 420 481 Cytoplasmic (Potential). FT COMPBIAS 418 439 Cys-rich. FT CARBOHYD 105 105 N-linked (GlcNAc...) (Potential). FT DISULFID 203 286 By similarity. SQ SEQUENCE 481 AA; 52729 MW; D7CF26B83B7F6E8C CRC64; MRWLWPLAVS LVVVLTVGLS GVSGAATSSL GGHRAKVQEQ QSRPRRGTKD EGPKEVQHYV PEEWAEYPKP IHPAGLQPTK TLEATSPNPD KDGATPGNGQ ELRVNLTGTP SQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA KLAVIWVGSM MLAVPELLLW QLAQEPAPTA GTVDSCIMKP SADLPESVYS LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKPECRAGRH EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASDSSATVS ADSKLKAEVS SSIYFHKPRE SPPLLPLGTP C // ID ADMR_MOUSE STANDARD; PRT; 395 AA. AC P43142; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 18-APR-2006, entry version 44. DE Adrenomedullin receptor (AM-R) (G10D) (NOW). GN Name=Admr; Synonyms=Gpcr22; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/c; TISSUE=Brain; RA Saeki Y., Ueno S., Nagai Y., Yanagihara T.; RL Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 149-262. RC TISSUE=Testis; RX MEDLINE=94116980; PubMed=8288218; RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., RA Copeland N.G., Jenkins N.A.; RT "Identification, chromosomal location, and genome organization of RT mammalian G-protein-coupled receptors."; RL Genomics 18:175-184(1993). CC -!- FUNCTION: Receptor for adrenomedullin. The activity of this CC receptor is mediated by G proteins which activate adenylate CC cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in liver and lung. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; D17292; BAA04125.1; -; mRNA. DR EMBL; L20338; AAA16849.1; -; mRNA. DR PIR; I48909; I48909. DR UniGene; Mm.2857; -. DR MGI; MGI:109545; Admr. DR InterPro; IPR001350; G10D_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF171; G10D_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00643; G10DORPHANR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 395 Adrenomedullin receptor. FT /FTId=PRO_0000069113. FT TOPO_DOM 1 53 Extracellular (Potential). FT TRANSMEM 54 75 1 (Potential). FT TOPO_DOM 76 86 Cytoplasmic (Potential). FT TRANSMEM 87 109 2 (Potential). FT TOPO_DOM 110 123 Extracellular (Potential). FT TRANSMEM 124 145 3 (Potential). FT TOPO_DOM 146 166 Cytoplasmic (Potential). FT TRANSMEM 167 189 4 (Potential). FT TOPO_DOM 190 213 Extracellular (Potential). FT TRANSMEM 214 235 5 (Potential). FT TOPO_DOM 236 254 Cytoplasmic (Potential). FT TRANSMEM 255 276 6 (Potential). FT TOPO_DOM 277 295 Extracellular (Potential). FT TRANSMEM 296 316 7 (Potential). FT TOPO_DOM 317 395 Cytoplasmic (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT DISULFID 122 198 By similarity. SQ SEQUENCE 395 AA; 45497 MW; 879EB108982F1710 CRC64; MSVIPSPRPV STLEPDNDFR DIHNWTELLH LFNQTFTDCH IEFNENTKHV VLFVFYLAIF VVGLVENVLV ICVNCRRSGR VGMLNLYILN MAIADLGIIL SLPVWMLEVM LEYTWLWGSF SCRFIHYFYL VNMYSSIFFL TCLSIDRYVT LTNTSPSWQR HQHRIRRAVC AGVWVLSAII PLPEVVHIQL LDGSEPMCLF LAPFETYSAW ALAVALSATI LGFLLPFLLI AVFNILTACR LRRQRQTESR RHCLLMWAYI VVFAICWLPY QVTMLLLTLH GTHIFLHCHL VNLLYFFYEI IDCFSMLHCV ANPILYNFLS PSFRGRLLSL VVRYLPKEQA RAAGGRASSS SSTQHSIIIT KEGSLPLQRI STPTPSETFR RPLRLQTPHL HSAIL // ID CCR3_MOUSE STANDARD; PRT; 359 AA. AC P51678; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 18-APR-2006, entry version 46. DE Probable C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) DE (CCR3) (CKR3) (Macrophage inflammatory protein 1-alpha receptor-like DE 2) (MIP-1 alpha RL2) (CD193 antigen). GN Name=Ccr3; Synonyms=Cmkbr1l2, Cmkbr3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; RX MEDLINE=96072806; PubMed=7594543; RA Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N., RA Gerard C.; RT "Molecular characterization of two murine eosinophil beta chemokine RT receptors."; RL J. Immunol. 155:5299-5305(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX MEDLINE=95340546; PubMed=7542241; DOI=10.1074/jbc.270.29.17494; RA Gao J.-L., Murphy P.M.; RT "Cloning and differential tissue-specific expression of three mouse RT beta chemokine receptor-like genes, including the gene for a RT functional macrophage inflammatory protein-1 alpha receptor."; RL J. Biol. Chem. 270:17494-17501(1995). CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to eotaxin, CC MCP-3, MCP-4 and RANTES and subsequently transduces a signal by CC increasing the intracellular calcium ions level. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Detected in skeletal muscle and in trace CC amounts in leukocytes. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U29677; AAA86118.1; -; Genomic_DNA. DR EMBL; U28406; AAA89155.1; -; Genomic_DNA. DR UniGene; Mm.57050; -. DR Ensembl; ENSMUSG00000035448; Mus musculus. DR MGI; MGI:104616; Ccr3. DR GO; GO:0016493; F:C-C chemokine receptor activity; IDA. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0006935; P:chemotaxis; IDA. DR InterPro; IPR002238; CC_3_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01108; CHEMOKINER3. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 359 Probable C-C chemokine receptor type 3. FT /FTId=PRO_0000069242. FT TOPO_DOM 1 38 Extracellular (Potential). FT TRANSMEM 39 64 1 (Potential). FT TOPO_DOM 65 68 Cytoplasmic (Potential). FT TRANSMEM 69 95 2 (Potential). FT TOPO_DOM 96 111 Extracellular (Potential). FT TRANSMEM 112 133 3 (Potential). FT TOPO_DOM 134 150 Cytoplasmic (Potential). FT TRANSMEM 151 175 4 (Potential). FT TOPO_DOM 176 201 Extracellular (Potential). FT TRANSMEM 202 227 5 (Potential). FT TOPO_DOM 228 243 Cytoplasmic (Potential). FT TRANSMEM 244 268 6 (Potential). FT TOPO_DOM 269 285 Extracellular (Potential). FT TRANSMEM 286 309 7 (Potential). FT TOPO_DOM 310 359 Cytoplasmic (Potential). FT DISULFID 110 187 By similarity. FT CONFLICT 270 270 R -> S (in Ref. 2). SQ SEQUENCE 359 AA; 41826 MW; AC11ED66E283CEAF CRC64; MAFNTDEIKT VVESFETTPY EYEWAPPCEK VRIKELGSWL LPPLYSLVFI IGLLGNMMVV LILIKYRKLQ IMTNIYLFNL AISDLLFLFT VPFWIHYVLW NEWGFGHYMC KMLSGFYYLA LYSEIFFIIL LTIDRYLAIV HAVFALRART VTFATITSII TWGLAGLAAL PEFIFHESQD SFGEFSCSPR YPEGEEDSWK RFHALRMNIF GLALPLLVMV ICYSGIIKTL LRCPNKKKHK AIRLIFVVMI VFFIFWTPYN LVLLFSAFHR TFLETSCEQS KHLDLAMQVT EVIAYTHCCV NPVIYAFVGE RFRKHLRLFF HRNVAVYLGK YIPFLPGEKM ERTSSVSPST GEQEISVVF // ID CCR3_MACFA STANDARD; PRT; 355 AA. AC Q9BDS8; DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 18-APR-2006, entry version 25. DE C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) DE (CKR3) (CD193 antigen). GN Name=CCR3; Synonyms=CMKBR3; OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=21134756; PubMed=11242524; DOI=10.1089/08892220150503744; RA Wade-Evans A.M., Russell J., Jenkins A., Javan C.; RT "Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33: RT potential coreceptors for HIV type 1, HIV type 2, and SIV."; RL AIDS Res. Hum. Retroviruses 17:371-375(2001). CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to eotaxin, CC MCP-3, MCP-4 and RANTES and subsequently transduces a signal by CC increasing the intracellular calcium ions level (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF291668; AAK25739.1; -; mRNA. DR InterPro; IPR002238; CC_3_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01108; CHEMOKINER3. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 355 C-C chemokine receptor type 3. FT /FTId=PRO_0000069240. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 62 1 (Potential). FT TOPO_DOM 63 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT TOPO_DOM 94 107 Extracellular (Potential). FT TRANSMEM 108 129 3 (Potential). FT TOPO_DOM 130 146 Cytoplasmic (Potential). FT TRANSMEM 147 171 4 (Potential). FT TOPO_DOM 172 203 Extracellular (Potential). FT TRANSMEM 204 223 5 (Potential). FT TOPO_DOM 224 239 Cytoplasmic (Potential). FT TRANSMEM 240 264 6 (Potential). FT TOPO_DOM 265 281 Extracellular (Potential). FT TRANSMEM 282 305 7 (Potential). FT TOPO_DOM 306 355 Cytoplasmic (Potential). FT DISULFID 106 183 By similarity. SQ SEQUENCE 355 AA; 40915 MW; 2B7865A177D261CE CRC64; MTTSLDTVET FGPTSYDDDM GLLCEKADVG ALIAQFVPPL YSLVFMVGLL GNVVVVMILI KYRRLRIMTN IYLLNLAISD LLFLFTLPFW IHYVRERNWV FSHGMCKVLS GFYHTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG VVTSIVTWGL AVLAALPEFI FYGTEELFPE TLCSAIYPQD TVYSWRHFHT LRMTILCLAL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL IFVIMAVFFI FWTPYNVAIL ISTYQSILFG PDCERSKHLD LFVLVTEVIA YSHCWVNPVI YAFVGERFRK YLRHFFHRHV LMHPGKYIPF LPSEKLERTS SVSPSTAEPE LSIVF // ID CC1L1_MOUSE STANDARD; PRT; 356 AA. AC P51676; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 18-APR-2006, entry version 41. DE C-C chemokine receptor 1-like protein 1 (Macrophage inflammatory DE protein 1 alpha receptor-like 1). GN Name=Ccr1l1; Synonyms=Cmkbr1l1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX MEDLINE=95340546; PubMed=7542241; DOI=10.1074/jbc.270.29.17494; RA Gao J.-L., Murphy P.M.; RT "Cloning and differential tissue-specific expression of three mouse RT beta chemokine receptor-like genes, including the gene for a RT functional macrophage inflammatory protein-1 alpha receptor."; RL J. Biol. Chem. 270:17494-17501(1995). CC -!- FUNCTION: Probable receptor for a C-C type chemokine. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Detected in the spleen, liver and leukocytes. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U28405; AAA89154.1; -; Genomic_DNA. DR PIR; I49340; I49340. DR Ensembl; ENSMUSG00000064039; Mus musculus. DR MGI; MGI:104617; Ccr1l1. DR InterPro; IPR002236; CC_1_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01106; CHEMOKINER1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 356 C-C chemokine receptor 1-like protein 1. FT /FTId=PRO_0000069298. FT TOPO_DOM 1 32 Extracellular (Potential). FT TRANSMEM 33 60 1 (Potential). FT TOPO_DOM 61 67 Cytoplasmic (Potential). FT TRANSMEM 68 92 2 (Potential). FT TOPO_DOM 93 108 Extracellular (Potential). FT TRANSMEM 109 130 3 (Potential). FT TOPO_DOM 131 147 Cytoplasmic (Potential). FT TRANSMEM 148 172 4 (Potential). FT TOPO_DOM 173 198 Extracellular (Potential). FT TRANSMEM 199 224 5 (Potential). FT TOPO_DOM 225 240 Cytoplasmic (Potential). FT TRANSMEM 241 265 6 (Potential). FT TOPO_DOM 266 282 Extracellular (Potential). FT TRANSMEM 283 306 7 (Potential). FT TOPO_DOM 307 356 Cytoplasmic (Potential). FT DISULFID 107 184 By similarity. SQ SEQUENCE 356 AA; 40934 MW; 58C01ABA8D7D4B06 CRC64; MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVPTP LYSLVFIIGV IGHVLVVLVL IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW IFGNAMCKFV SGFYYLGLYS DMFFITLLTI DRYLAVVHVV FALRARTVTF GIISSIITWV LAALVSIPCL YVFKSQMEFT YHTCRAILPR KSLIRFLRFQ ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR LIFVITLLFF LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSEDRAQRA SARLPSTVEI ETSADL // ID CCR5_ALOSE STANDARD; PRT; 352 AA. AC Q95NC9; DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 18-APR-2006, entry version 26. DE C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) DE (CD195 antigen). GN Name=CCR5; Synonyms=CMKBR5; OS Alouatta seniculus (Red howler monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Atelidae; Alouattinae; Alouatta. OX NCBI_TaxID=9503; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Zhang Y.-W., Ryder O.A., Zhang Y.-P.; RT "Sequence comparison of the CCR5 gene in primates and primate RT phylogeny."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, CC MIP-1-beta and RANTES and subsequently transduces a signal by CC increasing the intracellular calcium ions level. May play a role CC in the control of granulocytic lineage proliferation or CC differentiation. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF177880; AAK43363.1; -; Genomic_DNA. DR InterPro; IPR002240; CC_5_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01110; CHEMOKINER5. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Sulfation; Transducer; Transmembrane. FT CHAIN 1 352 C-C chemokine receptor type 5. FT /FTId=PRO_0000069247. FT TOPO_DOM 1 30 Extracellular (Potential). FT TRANSMEM 31 58 1 (Potential). FT TOPO_DOM 59 68 Cytoplasmic (Potential). FT TRANSMEM 69 89 2 (Potential). FT TOPO_DOM 90 102 Extracellular (Potential). FT TRANSMEM 103 124 3 (Potential). FT TOPO_DOM 125 141 Cytoplasmic (Potential). FT TRANSMEM 142 166 4 (Potential). FT TOPO_DOM 167 198 Extracellular (Potential). FT TRANSMEM 199 218 5 (Potential). FT TOPO_DOM 219 235 Cytoplasmic (Potential). FT TRANSMEM 236 260 6 (Potential). FT TOPO_DOM 261 277 Extracellular (Potential). FT TRANSMEM 278 301 7 (Potential). FT TOPO_DOM 302 352 Cytoplasmic (Potential). FT MOD_RES 3 3 Sulfotyrosine (By similarity). FT MOD_RES 10 10 Sulfotyrosine (By similarity). FT CARBOHYD 268 268 N-linked (GlcNAc...) (Potential). FT DISULFID 101 178 By similarity. SQ SEQUENCE 352 AA; 40421 MW; 3DBB43D1CCA48687 CRC64; MDYQVSSPIY DIDYGASEPC QKTDVKQMGA HLLPPLYSIV FLFGFVGNML VVLILINCKR PKSMTDIYLL NLAISDLFFL FTVPFWAHYA AGQWDFGNTM CQFLTGLYFI GFFSGIFFII LLTIDRYLAI VHAVFALKAR TVTFGVVTSV TTWVVAVFAS LPGIIFTRSQ KEGYHYTCSP HFPFGQYQFW KNFETLKMVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFAI MIVYFIFWAP YNIVLLLNTY QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CVNPIIYAFV GEKFRNYLLV FFQKHIAKRF CKCCSIFQKE APERANSVYT RSTGEQEISV GL // ID CX3C1_MOUSE STANDARD; PRT; 354 AA. AC Q9Z0D9; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 18-APR-2006, entry version 41. DE CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Fractalkine DE receptor). GN Name=Cx3cr1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/Sv; RX MEDLINE=99119076; PubMed=9918795; DOI=10.1006/bbrc.1998.9849; RA Combadiere C., Gao J.-L., Tiffany H.L., Murphy P.M.; RT "Gene cloning, RNA distribution, and functional expression of mCX3CR1, RT a mouse chemotactic receptor for the CX3C chemokine fractalkine."; RL Biochem. Biophys. Res. Commun. 253:728-732(1998). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/SvJ; RA Coultas L., McColl S.R.; RT "Cloning and characterization of murine CX3CR1, a receptor for murine RT fractalkine/neurotactin."; RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Czech II; TISSUE=Mammary gland; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for the CX3C chemokine fractalkine and mediates CC both its adhesive and migratory functions. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: This protein is not N-glycosylated which is unusual for G- CC protein-coupled receptors. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF074912; AAD08665.1; -; Genomic_DNA. DR EMBL; AF102269; AAC72408.1; -; mRNA. DR EMBL; BC012653; AAH12653.1; -; mRNA. DR UniGene; Mm.44065; -. DR Ensembl; ENSMUSG00000052336; Mus musculus. DR MGI; MGI:1333815; Cx3cr1. DR InterPro; IPR005387; Fractlkin_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF198; Fractlkin_recept; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01562; FRACTALKINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 354 CX3C chemokine receptor 1. FT /FTId=PRO_0000069327. FT TOPO_DOM 1 32 Extracellular (Potential). FT TRANSMEM 33 60 1 (Potential). FT TOPO_DOM 61 70 Cytoplasmic (Potential). FT TRANSMEM 71 91 2 (Potential). FT TOPO_DOM 92 104 Extracellular (Potential). FT TRANSMEM 105 126 3 (Potential). FT TOPO_DOM 127 143 Cytoplasmic (Potential). FT TRANSMEM 144 168 4 (Potential). FT TOPO_DOM 169 196 Extracellular (Potential). FT TRANSMEM 197 216 5 (Potential). FT TOPO_DOM 217 232 Cytoplasmic (Potential). FT TRANSMEM 233 257 6 (Potential). FT TOPO_DOM 258 274 Extracellular (Potential). FT TRANSMEM 275 298 7 (Potential). FT TOPO_DOM 299 354 Cytoplasmic (Potential). FT DISULFID 103 176 By similarity. SQ SEQUENCE 354 AA; 40266 MW; 12C745E8E3755CA9 CRC64; MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN LLVVLALTNS RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN AMCKLTTAFF FIGFFGGIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI SLGVWAAAIL VASPQFMFTK RKDNECLGDY PEVLQEMWPV LRNSEVNILG FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA FFLFWTPYNI MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG SLLL // ID CCR8_MOUSE STANDARD; PRT; 353 AA. AC P56484; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 1. DT 18-APR-2006, entry version 44. DE C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8). GN Name=Ccr8; Synonyms=Cmkbr8, Ter1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RA Zaballos A., Goya I.I., Gutierrez J., Varona R., Marquez G.; RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/Sv; RX MEDLINE=98334001; PubMed=9670926; RA Zingoni A., Soto H., Hedrick J.A., Stoppacciaro A., Storlazzi C.T., RA Sinigaglia F., D'Ambrosio D., O'Garra A., Robinson D., Rocchi M., RA Santoni A., Zlotnik A., Napolitano M.; RT "The chemokine receptor CCR8 is preferentially expressed in Th2 but RT not Th1 cells."; RL J. Immunol. 161:547-551(1998). CC -!- FUNCTION: Receptor for the TCA-3 chemokine. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Z98206; CAB10896.1; -; Genomic_DNA. DR EMBL; Z98205; CAB10895.1; -; mRNA. DR EMBL; AF001277; AAC97598.1; -; Genomic_DNA. DR UniGene; Mm.8000; -. DR Ensembl; ENSMUSG00000042262; Mus musculus. DR MGI; MGI:1201402; Ccr8. DR GO; GO:0016493; F:C-C chemokine receptor activity; IDA. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0006935; P:chemotaxis; IDA. DR InterPro; IPR004068; CC_8_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01530; CHEMOKINER8. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 353 C-C chemokine receptor type 8. FT /FTId=PRO_0000069290. FT TOPO_DOM 1 33 Extracellular (Potential). FT TRANSMEM 34 61 1 (Potential). FT TOPO_DOM 62 71 Cytoplasmic (Potential). FT TRANSMEM 72 91 2 (Potential). FT TOPO_DOM 92 105 Extracellular (Potential). FT TRANSMEM 106 127 3 (Potential). FT TOPO_DOM 128 144 Cytoplasmic (Potential). FT TRANSMEM 145 169 4 (Potential). FT TOPO_DOM 170 200 Extracellular (Potential). FT TRANSMEM 201 220 5 (Potential). FT TOPO_DOM 221 236 Cytoplasmic (Potential). FT TRANSMEM 237 261 6 (Potential). FT TOPO_DOM 262 278 Extracellular (Potential). FT TRANSMEM 279 302 7 (Potential). FT TOPO_DOM 303 353 Cytoplasmic (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT DISULFID 104 181 By similarity. SQ SEQUENCE 353 AA; 40045 MW; 31EC4B642CDB9AE5 CRC64; MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG NSLVILVLVG CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG TAMCKVVSGL YYIGFFSSMF FITLMSVDRY LAIVHAVYAI KVRTASVGTA LSLTVWLAAV TATIPLMVFY QVASEDGMLQ CFQFYEEQSL RWKLFTHFEI NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT VVIVSLLFWV PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD DIL // ID CCBP2_HUMAN STANDARD; PRT; 384 AA. AC O00590; O00537; Q86UN9; Q96A02; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 02-MAY-2002, sequence version 2. DT 18-APR-2006, entry version 58. DE Chemokine-binding protein 2 (Chemokine-binding protein D6) (C-C DE chemokine receptor D6) (Chemokine receptor CCR-9) (Chemokine receptor DE CCR-10). GN Name=CCBP2; Synonyms=CCR10, CMBRK9; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Lung; RX MEDLINE=98030218; PubMed=9364936; RA Bonini J.A., Martin S.K., Dralyuk F., Roe M.W., Philipson L.H., RA Steiner D.F.; RT "Cloning, expression, and chromosomal mapping of a novel human CC- RT chemokine receptor (CCR10) that displays high-affinity binding for RT MCP-1 and MCP-3."; RL DNA Cell Biol. 16:1249-1256(1997). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=98070370; PubMed=9405404; DOI=10.1074/jbc.272.51.32078; RA Nibbs R.J.B., Wylie S.M., Yang J., Landau N.R., Graham G.J.; RT "Cloning and characterization of a novel promiscuous human beta- RT chemokine receptor D6."; RL J. Biol. Chem. 272:32078-32083(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP TISSUE SPECIFICITY. RX MEDLINE=21134058; PubMed=11238036; RA Nibbs R.J.B., Kriehuber E., Ponath P.D., Parent D., Qin S., RA Campbell J.D., Henderson A., Kerjaschki D., Maurer D., Graham G.J., RA Rot A.; RT "The beta-chemokine receptor D6 is expressed by lymphatic endothelium RT and a subset of vascular tumors."; RL Am. J. Pathol. 158:867-877(2001). CC -!- FUNCTION: Receptor for C-C type chemokines including SCYA2/MCP-1, CC SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed primarily in placenta and fetal CC liver, and found at very low levels in the lung and lymph node. CC Found in endothelial cells lining afferent lymphatics in dermis CC and lymph nodes. Also found in lymph nodes subcapsular and CC medullary sinuses, tonsillar lymphatic sinuses and lymphatics in CC mucosa and submucosa of small and large intestine and appendix. CC Also found in some malignant vascular tumors. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U94888; AAB97728.1; -; mRNA. DR EMBL; Y12815; CAA73346.1; -; mRNA. DR EMBL; AY262687; AAP20651.1; -; Genomic_DNA. DR EMBL; BC020558; AAH20558.1; -; mRNA. DR EMBL; BC011631; AAH11631.1; -; mRNA. DR EMBL; BC008816; AAH08816.1; -; mRNA. DR UniGene; Hs.24286; -. DR Ensembl; ENSG00000144648; Homo sapiens. DR H-InvDB; HIX0022805; -. DR HGNC; HGNC:1565; CCBP2. DR MIM; 602648; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007275; P:development; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0006955; P:immune response; TAS. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 384 Chemokine-binding protein 2. FT /FTId=PRO_0000069219. FT TOPO_DOM 1 50 Extracellular (Potential). FT TRANSMEM 51 71 1 (Potential). FT TOPO_DOM 72 92 Cytoplasmic (Potential). FT TRANSMEM 93 113 2 (Potential). FT TOPO_DOM 114 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT TOPO_DOM 141 162 Cytoplasmic (Potential). FT TRANSMEM 163 183 4 (Potential). FT TOPO_DOM 184 217 Extracellular (Potential). FT TRANSMEM 218 238 5 (Potential). FT TOPO_DOM 239 250 Cytoplasmic (Potential). FT TRANSMEM 251 271 6 (Potential). FT TOPO_DOM 272 293 Extracellular (Potential). FT TRANSMEM 294 314 7 (Potential). FT TOPO_DOM 315 384 Cytoplasmic (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT DISULFID 117 195 By similarity. FT VARIANT 373 373 Y -> S (in dbSNP:2228468). FT /FTId=VAR_024252. FT CONFLICT 17 17 S -> A (in Ref. 1). FT CONFLICT 161 161 S -> N (in Ref. 1). FT CONFLICT 356 356 Q -> L (in Ref. 1). SQ SEQUENCE 384 AA; 43443 MW; 464C5703C1DE9A6A CRC64; MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP VFYSLIFVLG LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP FWGISVAWHW VFGSFLCKMV STLYTINFYS GIFFISCMSL DKYLEIVHAQ PYHRLRTRAK SLLLATIVWA VSLAVSIPDM VFVQTHENPK GVWNCHADFG GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL RPAGQGRALK IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES SILTAQEEMT GMNDLGERQS ENYPNKEDVG NKSA // ID XCR1_MOUSE STANDARD; PRT; 322 AA. AC Q9R0M1; DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 18-APR-2006, entry version 42. DE Chemokine XC receptor 1 (XC chemokine receptor 1) (Lymphotactin DE receptor) (SCM1 receptor) (mXCR1). GN Name=Xcr1; Synonyms=Ccxcr1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX MEDLINE=99448374; PubMed=10518929; DOI=10.1016/S0014-5793(99)01114-X; RA Yoshida T., Izawa D., Nakayama T., Nakahara K., Kakizaki M., Imai T., RA Suzuki R., Miyasaka M., Yoshie O.; RT "Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor."; RL FEBS Lett. 458:37-40(1999). CC -!- FUNCTION: Receptor for chemokines SCYC1 and SCYC2. Subsequently CC transduces a signal by increasing the intracellular calcium ions CC level. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB028459; BAA85419.1; -; Genomic_DNA. DR UniGene; Mm.89202; -. DR Ensembl; ENSMUSG00000060509; Mus musculus. DR MGI; MGI:1346338; Xcr1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005393; Lymphotact_rcpt. DR PANTHER; PTHR19264:SF181; Lymphtact_recept; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01568; LYMPHOTACTNR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 322 Chemokine XC receptor 1. FT /FTId=PRO_0000070222. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 55 1 (Potential). FT TOPO_DOM 56 65 Cytoplasmic (Potential). FT TRANSMEM 66 85 2 (Potential). FT TOPO_DOM 86 98 Extracellular (Potential). FT TRANSMEM 99 120 3 (Potential). FT TOPO_DOM 121 137 Cytoplasmic (Potential). FT TRANSMEM 138 162 4 (Potential). FT TOPO_DOM 163 185 Extracellular (Potential). FT TRANSMEM 186 204 5 (Potential). FT TOPO_DOM 205 220 Cytoplasmic (Potential). FT TRANSMEM 221 243 6 (Potential). FT TOPO_DOM 244 259 Extracellular (Potential). FT TRANSMEM 260 283 7 (Potential). FT TOPO_DOM 284 322 Cytoplasmic (Potential). FT DISULFID 97 170 By similarity. SQ SEQUENCE 322 AA; 37308 MW; 89A5573BD97A1CA3 CRC64; MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW VLVKYENLES LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF NMIFGISLYS SIFFLTIMTI HRYLSVVSPI STLGIHTLRC RVLVTSCVWA ASILFSIPDA VFHKVISLNC KYSEHHGFLA SVYQHNIFFL LSMGIILFCY VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL FLKTGIIQQS CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC RKTSSTVPCS PGTFTYEGPS FY // // ID CXCR3_BOVIN STANDARD; PRT; 366 AA. AC Q5MD61; DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-2005, sequence version 1. DT 04-APR-2006, entry version 13. DE C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (Interferon- DE inducible protein 10 receptor) (IP-10 receptor). GN Name=CXCR3; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Blumerman S.L., Baldwin C.L.; RT "Molecular cloning and characterization of bovine chemokine RT receptors."; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for CXCL9, CXCL10 and CXCL11 (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein (By CC similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY834254; AAV97931.1; -; mRNA. DR UniGene; Bt.25919; -. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR004070; CXC_3_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF185; CXC_3_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01532; CXCCHMKINER3. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 366 C-X-C chemokine receptor type 3. FT /FTId=PRO_0000069343. FT TOPO_DOM 1 55 Extracellular (Potential). FT TRANSMEM 56 76 1 (Potential). FT TOPO_DOM 77 88 Cytoplasmic (Potential). FT TRANSMEM 89 109 2 (Potential). FT TOPO_DOM 110 124 Extracellular (Potential). FT TRANSMEM 125 145 3 (Potential). FT TOPO_DOM 146 167 Cytoplasmic (Potential). FT TRANSMEM 168 188 4 (Potential). FT TOPO_DOM 189 221 Extracellular (Potential). FT TRANSMEM 222 242 5 (Potential). FT TOPO_DOM 243 254 Cytoplasmic (Potential). FT TRANSMEM 255 275 6 (Potential). FT TOPO_DOM 276 299 Extracellular (Potential). FT TRANSMEM 300 320 7 (Potential). FT TOPO_DOM 321 366 Cytoplasmic (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT CARBOHYD 30 30 N-linked (GlcNAc...) (Potential). FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential). FT DISULFID 122 201 By similarity. SQ SEQUENCE 366 AA; 40805 MW; 0889D2E73A1579E2 CRC64; MVPEMSERQE FQASDFAYLL ENSSYDYGEN ETYFCCTSPP CPQDFSLNFD RTFLPVLYSL LFVLGLLGNG IVAVVLLSQR AALSSTDTFL LHLAVADALL VLTLPLWAVD AAIQWVFGSG LCKVAGALFN INFYAGALLL ACISFDRYLS IVHATQLYRR GPPTRVALTC VAVWGLCLLF ALPDFIFLSS HHDNRLNATH CQYNFPQEGH TALRILQLVA GFLLPLLVMA YCYARILAVL LVSRGQRRLR AMRLVVVVVV AFALCWTPYH LVVLVDTLMD LGALARNCGR ESSVDIAKSV TSGMGYMHCC LNPLLYAFVG VKFRERMWVL LVRLGCPDQR CHQRQPSASR RESSWSETTE ASYSGL // ID CXCR2_CANFA STANDARD; PRT; 356 AA. AC O97571; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 02-MAY-2006, entry version 39. DE High affinity interleukin-8 receptor B (IL-8R B) (CXCR-2) (GRO/MGSA DE receptor) (CD182 antigen). GN Name=IL8RB; Synonyms=CXCR2; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Beagle; RX MEDLINE=20112347; PubMed=10647821; RA Chang Y.F., Novosel V., Chang C.F.; RT "The isolation and sequence of canine interleukin-8 receptor."; RL DNA Seq. 10:183-187(1999). CC -!- FUNCTION: Receptor to interleukin-8, which is a powerful CC neutrophils chemotactic factor. Binding of IL-8 to the receptor CC causes activation of neutrophils. This response is mediated via a CC G-protein that activate a phosphatidylinositol-calcium second CC messenger system. The affinity of this receptor is IL-8 >> NAP-2 > CC MGSA (GRO). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated upon ligand binding; which is required for CC desensitization (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF047047; AAC98968.1; -; mRNA. DR UniGene; Cfa.3635; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSCAFG00000014612; Canis familiaris. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000174; IL8_rcpt. DR InterPro; IPR000057; IL8B_rcpt. DR PANTHER; PTHR19264:SF183; IL8_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00427; INTRLEUKIN8R. DR PRINTS; PR00573; INTRLEUKN8BR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Receptor; Sensory transduction; Transducer; KW Transmembrane. FT CHAIN 1 356 High affinity interleukin-8 receptor B. FT /FTId=PRO_0000069335. FT TOPO_DOM 1 46 Extracellular (Potential). FT TRANSMEM 47 73 1 (Potential). FT TOPO_DOM 74 82 Cytoplasmic (Potential). FT TRANSMEM 83 103 2 (Potential). FT TOPO_DOM 104 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT TOPO_DOM 141 161 Cytoplasmic (Potential). FT TRANSMEM 162 181 4 (Potential). FT TOPO_DOM 182 206 Extracellular (Potential). FT TRANSMEM 207 229 5 (Potential). FT TOPO_DOM 230 249 Cytoplasmic (Potential). FT TRANSMEM 250 269 6 (Potential). FT TOPO_DOM 270 290 Extracellular (Potential). FT TRANSMEM 291 311 7 (Potential). FT TOPO_DOM 312 356 Cytoplasmic (Potential). FT MOD_RES 343 343 Phosphoserine (By similarity). FT MOD_RES 347 347 Phosphoserine (By similarity). FT MOD_RES 348 348 Phosphoserine (By similarity). FT MOD_RES 349 349 Phosphoserine (By similarity). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT DISULFID 117 194 By similarity. SQ SEQUENCE 356 AA; 40505 MW; 2B67DD4E8DD39B15 CRC64; MEYINWDNYS LEDLFGDIDN YTYNTEMPII PADSAPCRPE SLDINKYAVV VIYVLVFVLN LLGNSLVIMV VLYSRVSHSV TDVYLLNLAI ADLLFALTLP IWAVSKVKGW IFGTPLCKIV SLLKEVNFYS GILLLASISM DRYLAIVHAT RRLTQKKHWV KFICLGIWAL SLILSLPIFV FRRAINPPYS SPVCYEDMGT NTTKLRIVMR ALPQTFGFIV PLMIMLFCYG LTLRTLFEAH MGQKHRAMRV IFAVVLVFLL CWLPYNLVAD TLMRLQAIEE TCQRRNDIGR ALDATEILGF FHSCLNPLIY AFIGQKFRHG LLKIMAFHGL ISKEYLPKDS RPSFVGSSSA NTSTTF // ID CXCR1_HUMAN STANDARD; PRT; 350 AA. AC P25024; Q9P2T8; Q9P2T9; Q9P2U0; Q9P2U1; Q9P2U2; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1992, sequence version 1. DT 18-APR-2006, entry version 61. DE High affinity interleukin-8 receptor A (IL-8R A) (IL-8 receptor type DE 1) (CXCR-1) (CD181 antigen) (CDw128a). GN Name=IL8RA; Synonyms=CXCR1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=91368199; PubMed=1840701; RA Holmes W.E., Lee J., Kuang W.-J., Rice G.C., Wood W.I.; RT "Structure and functional expression of a human interleukin-8 RT receptor."; RL Science 253:1278-1280(1991). RN [2] RP NUCLEOTIDE SEQUENCE, AND CHARACTERIZATION. RX MEDLINE=93205012; PubMed=8384312; DOI=10.1016/0161-5890(93)90065-J; RA Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., RA Beckmann M.P.; RT "Molecular characterization of receptors for human interleukin-8, RT GRO/melanoma growth-stimulatory activity and neutrophil activating RT peptide-2."; RL Mol. Immunol. 30:359-367(1993). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=93252387; PubMed=8486366; RA Mollereau C., Passage E., Mattei M.-G., Vassart G., Parmentier M.; RT "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the RT 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) RT for the low-affinity receptor."; RL Genomics 16:248-251(1993). RN [4] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta; RX MEDLINE=95014476; PubMed=7929358; RA Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M.; RT "Comparison of the genomic organization and promoter function for RT human interleukin-8 receptors A and B."; RL J. Biol. Chem. 269:26381-26389(1994). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., RA Korn B., Zuo D., Hu Y., LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-31; SER-276; RP CYS-335 AND LEU-342. RA Rieder M.J., Daniels R.L., da Ponte S.H., Hastings N.C., Ahearn M.O., RA Rajkumar N., Yi Q., Nickerson D.A.; RT "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW- RT FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE OF 223-350, AND VARIANTS SER-276; THR-306 AND RP CYS-335. RX MEDLINE=21040285; PubMed=11196695; DOI=10.1038/sj.gene.6363682; RA Kato H., Tsuchiya N., Tokunaga K.; RT "Single nucleotide polymorphisms in the coding regions of human CXC- RT chemokine receptors CXCR1, CXCR2 and CXCR3."; RL Genes Immun. 1:330-337(2000). RN [8] RP CHARACTERIZATION. RX MEDLINE=92355587; PubMed=1379593; RA Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I.; RT "Characterization of two high affinity human interleukin-8 RT receptors."; RL J. Biol. Chem. 267:16283-16287(1992). RN [9] RP STRUCTURE BY NMR OF 9-29 IN COMPLEX WITH IL-8. RX MEDLINE=99148123; PubMed=10368283; DOI=10.1016/S0969-2126(99)80022-7; RA Skelton N.J., Quan C., Reilly D., Lowman H.; RT "Structure of a CXC chemokine-receptor fragment in complex with RT interleukin-8."; RL Structure 7:157-168(1999). CC -!- FUNCTION: Receptor to interleukin-8, which is a powerful CC neutrophils chemotactic factor. Binding of IL-8 to the receptor CC causes activation of neutrophils. This response is mediated via a CC G-protein that activate a phosphatidylinositol-calcium second CC messenger system. This receptor binds to IL-8 with a high affinity CC and to MGSA (GRO) with a low affinity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L19591; AAB59436.1; -; mRNA. DR EMBL; L19592; AAA59160.1; -; Genomic_DNA. DR EMBL; M68932; AAA59159.1; -; mRNA. DR EMBL; X65858; CAA46688.1; -; Genomic_DNA. DR EMBL; U11870; AAA64378.1; -; Genomic_DNA. DR EMBL; CR541994; CAG46791.1; -; mRNA. DR EMBL; CR542029; CAG46826.1; -; mRNA. DR EMBL; AY651785; AAT46689.1; -; Genomic_DNA. DR EMBL; AB032728; BAA92290.1; -; Genomic_DNA. DR EMBL; AB032729; BAA92291.1; -; Genomic_DNA. DR EMBL; AB032730; BAA92292.1; -; Genomic_DNA. DR EMBL; AB032731; BAA92293.1; -; Genomic_DNA. DR EMBL; AB032732; BAA92294.1; -; Genomic_DNA. DR PIR; I37449; A39445. DR UniGene; Hs.194778; -. DR PDB; 1ILP; NMR; C=20-29. DR PDB; 1ILQ; NMR; C=20-29. DR Ensembl; ENSG00000163464; Homo sapiens. DR H-InvDB; HIX0002821; -. DR HGNC; HGNC:6026; IL8RA. DR MIM; 146929; gene. DR GO; GO:0016020; C:membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0004918; F:interleukin-8 receptor activity; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000174; IL8_rcpt. DR InterPro; IPR001355; IL8A_rcpt. DR PANTHER; PTHR19264:SF183; IL8_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00427; INTRLEUKIN8R. DR PRINTS; PR00572; INTRLEUKN8AR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW 3D-structure; Chemotaxis; G-protein coupled receptor; Glycoprotein; KW Membrane; Polymorphism; Receptor; Sensory transduction; Transducer; KW Transmembrane. FT CHAIN 1 350 High affinity interleukin-8 receptor A. FT /FTId=PRO_0000069330. FT TOPO_DOM 1 39 Extracellular (Potential). FT TRANSMEM 40 66 1 (Potential). FT TOPO_DOM 67 75 Cytoplasmic (Potential). FT TRANSMEM 76 96 2 (Potential). FT TOPO_DOM 97 111 Extracellular (Potential). FT TRANSMEM 112 133 3 (Potential). FT TOPO_DOM 134 154 Cytoplasmic (Potential). FT TRANSMEM 155 174 4 (Potential). FT TOPO_DOM 175 199 Extracellular (Potential). FT TRANSMEM 200 220 5 (Potential). FT TOPO_DOM 221 242 Cytoplasmic (Potential). FT TRANSMEM 243 264 6 (Potential). FT TOPO_DOM 265 285 Extracellular (Potential). FT TRANSMEM 286 308 7 (Potential). FT TOPO_DOM 309 350 Cytoplasmic (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 By similarity. FT VARIANT 31 31 M -> R. FT /FTId=VAR_021061. FT VARIANT 71 71 R -> C (in dbSNP:1805038). FT /FTId=VAR_016236. FT VARIANT 276 276 T -> S (common polymorphism; FT dbSNP:2234671). FT /FTId=VAR_003479. FT VARIANT 306 306 A -> T. FT /FTId=VAR_016237. FT VARIANT 335 335 R -> C. FT /FTId=VAR_016238. FT VARIANT 342 342 S -> L. FT /FTId=VAR_021062. FT STRAND 23 24 SQ SEQUENCE 350 AA; 39805 MW; 2463EEB51BEDD039 CRC64; MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQETCERR NNIGRALDAT EILGFLHSCL NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL // ID CXCR4_BOVIN STANDARD; PRT; 353 AA. AC P25930; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1992, sequence version 1. DT 04-APR-2006, entry version 48. DE C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (SDF-1 receptor) DE (Stromal cell-derived factor 1 receptor) (Fusin) (Leukocyte-derived DE seven transmembrane domain receptor) (LESTR) (LCR1) (CD184 antigen). GN Name=CXCR4; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Locus coeruleus; RX MEDLINE=92100053; PubMed=1661837; RA Rimland J., Xin W., Sweetnam P., Saijoh K., Nestler E.J., Duman R.S.; RT "Sequence and expression of a neuropeptide Y receptor cDNA."; RL Mol. Pharmacol. 40:869-875(1991). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Werling D.; RT "Role of chemokines in respiratory syncytial virus infection."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP SHOWS THAT IT IS NOT A NPY3R. RX MEDLINE=94052833; PubMed=8234909; DOI=10.1016/0167-0115(93)90392-L; RA Jazin E.E., Yoo H., Blomqvist A.G., Yee F., Weng G., Walker M.W., RA Salon J., Larhammar D., Wahlestedt C.R.; RT "A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its RT human homologue, confers neither NPY binding sites nor NPY RT responsiveness on transfected cells."; RL Regul. Pept. 47:247-258(1993). CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL12/SDF-1. CC Transduces a signal by increasing the intracellular calcium ions CC level. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain, heart, kidney, lung and liver. CC -!- PTM: Sulfated (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: Was originally (Ref.1) thought to be a receptor for CC neuropeptide Y type 3 (NPY3R) (NPY3-R). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M86739; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AF399642; AAK94452.1; -; mRNA. DR PIR; S28787; S28787. DR UniGene; Bt.8957; -. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Sulfation; Transducer; Transmembrane. FT CHAIN 1 353 C-X-C chemokine receptor type 4. FT /FTId=PRO_0000069349. FT TOPO_DOM 1 40 Extracellular (Potential). FT TRANSMEM 41 64 1 (Potential). FT TOPO_DOM 65 80 Cytoplasmic (Potential). FT TRANSMEM 81 100 2 (Potential). FT TOPO_DOM 101 111 Extracellular (Potential). FT TRANSMEM 112 133 3 (Potential). FT TOPO_DOM 134 155 Cytoplasmic (Potential). FT TRANSMEM 156 176 4 (Potential). FT TOPO_DOM 177 201 Extracellular (Potential). FT TRANSMEM 202 221 5 (Potential). FT TOPO_DOM 222 241 Cytoplasmic (Potential). FT TRANSMEM 242 262 6 (Potential). FT TOPO_DOM 263 286 Extracellular (Potential). FT TRANSMEM 287 306 7 (Potential). FT TOPO_DOM 307 353 Cytoplasmic (Potential). FT MOD_RES 22 22 Sulfotyrosine (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 By similarity. SQ SEQUENCE 353 AA; 39939 MW; 42FFE5BC7545505E CRC64; MEGIRIFTSD NYTEDDLGSG DYDSMKEPCF REENAHFNRI FLPTVYSIIF LTGIVGNGLV ILVMGYQKKL RSMTDKYRLH LSVADLLFVL TLPFWAVDAV ANWYFGKFLC KAVHVIYTVN LYSSVLILAF ISLDRYLAIV HATNSQKPRK LLAEKVVYVG VWLPAVLLTI PDLIFADIKE VDERYICDRF YPSDLWLVVF QFQHIVVGLL LPGIVILSCY CIIISKLSHS KGYQKRKALK TTVILILTFF ACWLPYYIGI SIDSFILLEI IQQGCEFEST VHKWISITEA LAFFHCCLNP ILYAFLGAKF KTSAQHALTS VSRGSSLKIL SKGKRGGHSS VSTESESSSF HSS // ID CCR9_HUMAN STANDARD; PRT; 357 AA. AC P51686; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 18-APR-2006, entry version 52. DE C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (GPR-9-6) DE (G-protein coupled receptor 28) (CDw199 antigen). GN Name=CCR9; Synonyms=CMKBR9, GPR28; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Lautens L.L., Tiffany H.L., Gao J.-L., Modi W., Murphy P.M., RA Bonner T.I.; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Warren C.N., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP CHARACTERIZATION. RX MEDLINE=99248139; PubMed=10229797; RA Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.; RT "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the RT receptor for the chemokine TECK."; RL J. Immunol. 162:5671-5675(1999). CC -!- FUNCTION: Receptor for chemokine SCYA25/TECK. Subsequently CC transduces a signal by increasing the intracellular calcium ions CC level. Alternative coreceptor with CD4 for HIV-1 infection. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Highly expressed in the thymus and low in CC lymph nodes and spleen. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U45982; AAA93319.1; -; Genomic_DNA. DR EMBL; AY242127; AAO92294.1; -; Genomic_DNA. DR UniGene; Hs.225946; -. DR Ensembl; ENSG00000173585; Homo sapiens. DR HGNC; HGNC:1610; CCR9. DR MIM; 604738; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004950; F:chemokine receptor activity; TAS. DR GO; GO:0006968; P:cellular defense response; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR004069; CC_9_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF190; CC_9_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01531; CHEMOKINER9. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 357 C-C chemokine receptor type 9. FT /FTId=PRO_0000069291. FT TOPO_DOM 1 37 Extracellular (Potential). FT TRANSMEM 38 64 1 (Potential). FT TOPO_DOM 65 73 Cytoplasmic (Potential). FT TRANSMEM 74 94 2 (Potential). FT TOPO_DOM 95 108 Extracellular (Potential). FT TRANSMEM 109 130 3 (Potential). FT TOPO_DOM 131 148 Cytoplasmic (Potential). FT TRANSMEM 149 169 4 (Potential). FT TOPO_DOM 170 198 Extracellular (Potential). FT TRANSMEM 199 226 5 (Potential). FT TOPO_DOM 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 268 6 (Potential). FT TOPO_DOM 269 292 Extracellular (Potential). FT TRANSMEM 293 310 7 (Potential). FT TOPO_DOM 311 357 Cytoplasmic (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT DISULFID 107 186 By similarity. FT VARIANT 272 272 M -> V (in dbSNP:12721497). FT /FTId=VAR_020068. SQ SEQUENCE 357 AA; 40713 MW; 96982E0B922F6B31 CRC64; MADDYGSEST SSMEDYVNFN FTDFYCEKNN VRQFASHFLP PLYWLVFIVG ALGNSLVILV YWYCTRVKTM TDMFLLNLAI ADLLFLVTLP FWAIAAADQW KFQTFMCKVV NSMYKMNFYS CVLLIMCISV DRYIAIAQAM RAHTWREKRL LYSKMVCFTI WVLAAALCIP EILYSQIKEE SGIAICTMVY PSDESTKLKS AVLTLKVILG FFLPFVVMAC CYTIIIHTLI QAKKSSKHKA LKVTITVLTV FVLSQFPYNC ILLVQTIDAY AMFISNCAVS TNIDICFQVT QTIAFFHSCL NPVLYVFVGE RFRRDLVKTL KNLGCISQAQ WVSFTRREGS LKLSSMLLET TSGALSL // ID CCRL1_BOVIN STANDARD; PRT; 350 AA. AC P35350; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 1. DT 04-APR-2006, entry version 45. DE C-C chemokine receptor type 11 (C-C CKR-11) (CC-CKR-11) (CCR-11) DE (Putative gustatory receptor type B) (PPR1 protein). GN Name=CCRL1; Synonyms=CCR11; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Tongue; RX MEDLINE=93326166; PubMed=8392843; RA Matsuoka I., Mori T., Aoki J., Sato T., Kurihara K.; RT "Identification of novel members of G-protein coupled receptor RT superfamily expressed in bovine taste tissue."; RL Biochem. Biophys. Res. Commun. 194:504-511(1993). CC -!- FUNCTION: Receptor for SCYA2/MCP1, SCYA8/MCP2, SCYA13/MCP4. CC SCYA19/MIP3B/ELC, SCYA21/SLC and SCYA25/TECK (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in circumvallate and fungiform CC papillae, olfactory epithelium and lung. Lower expression in CC liver, kidney and tongue epithelium bearing no taste papillae. CC Very low expression in the cerebral cortex of the brain. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; S63848; AAB27547.1; -; mRNA. DR PIR; JN0621; JN0621. DR UniGene; Bt.565; -. DR HSSP; P02699; 1BOJ. DR InterPro; IPR005383; CC_11_rcpt. DR InterPro; IPR000355; Chmkine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF186; CC_11_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01558; CHEMOKINER11. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphorylation; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 350 C-C chemokine receptor type 11. FT /FTId=PRO_0000069295. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 66 1 (Potential). FT TOPO_DOM 67 79 Cytoplasmic (Potential). FT TRANSMEM 80 99 2 (Potential). FT TOPO_DOM 100 113 Extracellular (Potential). FT TRANSMEM 114 135 3 (Potential). FT TOPO_DOM 136 153 Cytoplasmic (Potential). FT TRANSMEM 154 175 4 (Potential). FT TOPO_DOM 176 199 Extracellular (Potential). FT TRANSMEM 200 222 5 (Potential). FT TOPO_DOM 223 241 Cytoplasmic (Potential). FT TRANSMEM 242 265 6 (Potential). FT TOPO_DOM 266 283 Extracellular (Potential). FT TRANSMEM 284 306 7 (Potential). FT TOPO_DOM 307 350 Cytoplasmic (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT DISULFID 112 184 By similarity. SQ SEQUENCE 350 AA; 40008 MW; E46BF942F3919C82 CRC64; MAVEYNQSTD YYYEENEMND THDYSQYEVI CIKEEVRKFA KVFLPAFFTI AFIIGLAGNS TVVAIYAYYK KRRTKTDVYI LNLAVADLFL LFTLPFWAVN AVHGWVLGKI MCKVTSALYT VNFVSGMQFL ACISTDRYWA VTKAPSQSGV GKPCWVICFC VWVAAILLSI PQLVFYTVNH KARCVPIFPY HLGTSMKASI QILEICIGFI IPFLIMAVCY FITAKTLIKM PNIKKSQPLK VLFTVVIVFI VTQLPYNIVK FCQAIDIIYS LITDCDMSKR MDVAIQITES IALFHSCLNP VLYVFMGTSF KNYIMKVAKK YGSWRRQRQN VEEIPFESED ATEPTSTFSI // ID AGTR1_BOVIN STANDARD; PRT; 359 AA. AC P25104; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1992, sequence version 1. DT 04-APR-2006, entry version 44. DE Type-1 angiotensin II receptor (AT1). GN Name=AGTR1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=91251900; PubMed=2041569; DOI=10.1038/351230a0; RA Sasaki K., Yamano Y., Bardhan S., Iwai N., Murray J.J., Hasegawa M., RA Matsuda Y., Inagami T.; RT "Cloning and expression of a complementary DNA encoding a bovine RT adrenal angiotensin II type-1 receptor."; RL Nature 351:230-233(1991). CC -!- FUNCTION: Receptor for angiotensin II. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Adrenal medulla, cortex and kidney. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X62294; CAA44182.1; -; mRNA. DR UniGene; Bt.4539; -. DR HSSP; P34996; 1DDD. DR InterPro; IPR000248; Angtn2_rcpt. DR InterPro; IPR000190; AT1_rcpt. DR InterPro; IPR001186; BK_rcpt_B1. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF177; AT1_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00635; ANGIOTENSN1R. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 359 Type-1 angiotensin II receptor. FT /FTId=PRO_0000069150. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 52 1 (Potential). FT TOPO_DOM 53 64 Cytoplasmic (Potential). FT TRANSMEM 65 87 2 (Potential). FT TOPO_DOM 88 102 Extracellular (Potential). FT TRANSMEM 103 124 3 (Potential). FT TOPO_DOM 125 142 Cytoplasmic (Potential). FT TRANSMEM 143 162 4 (Potential). FT TOPO_DOM 163 192 Extracellular (Potential). FT TRANSMEM 193 214 5 (Potential). FT TOPO_DOM 215 240 Cytoplasmic (Potential). FT TRANSMEM 241 262 6 (Potential). FT TOPO_DOM 263 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT TOPO_DOM 297 359 Cytoplasmic (Potential). FT LIPID 355 355 S-palmitoyl cysteine (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 176 176 N-linked (GlcNAc...) (Potential). FT CARBOHYD 188 188 N-linked (GlcNAc...) (Potential). FT DISULFID 101 180 By similarity. SQ SEQUENCE 359 AA; 41088 MW; B426BFFF6B61DFEA CRC64; MILNSSTEDG IKRIQDDCPK AGRHNYIFIM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPTIIHRNVF FIENTNITVC AFHYESQNST LPVGLGLTKN ILGFLFPFLI ILTSYTLIWK TLKKAYEIQK NKPRKDDIFK IILAIVLFFF FSWVPHQIFT FMDVLIQLGL IRDCKIEDIV DTAMPITICL AYFNNCLNPL FYGFLGKKFK KYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSENGNSSTK KPAPCIEVE // ID BKRB1_MACFA STANDARD; PRT; 352 AA. AC Q3BCU0; DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 22-NOV-2005, sequence version 1. DT 18-APR-2006, entry version 7. DE B1 bradykinin receptor (BK-1 receptor) (B1R). GN Name=BDKRB1; OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung; RA Coombs S., Cortright D., Peck A.; RT "Cynomolgus monkey (Macaca fascicularis) bradykinin receptor B1 RT gene."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in CC chronic pain and inflammation (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY788905; AAX14712.1; -; mRNA. DR InterPro; IPR001186; BK_rcpt_B1. DR InterPro; IPR000496; Brdyknn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF174; BK_receptorB1; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00425; BRADYKININR. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 352 B1 bradykinin receptor. FT /FTId=PRO_0000069182. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 62 1 (Potential). FT TOPO_DOM 63 72 Cytoplasmic (Potential). FT TRANSMEM 73 93 2 (Potential). FT TOPO_DOM 94 110 Extracellular (Potential). FT TRANSMEM 111 131 3 (Potential). FT TOPO_DOM 132 153 Cytoplasmic (Potential). FT TRANSMEM 154 174 4 (Potential). FT TOPO_DOM 175 206 Extracellular (Potential). FT TRANSMEM 207 227 5 (Potential). FT TOPO_DOM 228 250 Cytoplasmic (Potential). FT TRANSMEM 251 271 6 (Potential). FT TOPO_DOM 272 294 Extracellular (Potential). FT TRANSMEM 295 315 7 (Potential). FT TOPO_DOM 316 352 Cytoplasmic (Potential). FT LIPID 329 329 S-palmitoyl cysteine (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT CARBOHYD 184 184 N-linked (GlcNAc...) (Potential). FT DISULFID 109 188 By similarity. SQ SEQUENCE 352 AA; 40217 MW; D9B2554238B94BD5 CRC64; MASWPPLQLQ SSNQSQLFPQ NATACDNAPE AWDLLHRVLP TFIISICSFG LLGNLFVLLV FLLPRRRLNV AEIYLANLAA SDLVFVLGLP FWAENIWNQF NWPFGALLCR VINGIIKANL FISIFLVVAI SQDRYCVLVH PMASRRRQRR RQARVTCVLI WVVGGLLSIP TFLLRSIQAV PDLNITACIL LLPHEAWHFA RIVELNILAF LLPLAAIIFF NYHILASLRG REEVSRTRCG GSKDSKTTAL ILTLVVAFLV CWAPYHFFAF LEFLFQVQAV RGCFWEDFID LGLQLANFLA FTNSSLNPVI YVFAGRLFRT KVWELYKQCT PKSLAPISSS HRKEIFQLFW RN // ID BKRB1_MOUSE STANDARD; PRT; 334 AA. AC Q61125; Q9Z1F4; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 18-APR-2006, entry version 47. DE B1 bradykinin receptor (BK-1 receptor) (B1R). GN Name=Bdkrb1; Synonyms=Bdkrb; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION. RC STRAIN=129/SvJ; RX MEDLINE=96176983; PubMed=8602848; DOI=10.1006/bbrc.1996.0384; RA Pesquero J.B., Pesquero J.L., Oliveira S.M., Roscher A.A., Metzger R., RA Ganten D., Bader M.; RT "Molecular cloning and functional characterization of a mouse RT bradykinin B1 receptor gene."; RL Biochem. Biophys. Res. Commun. 220:219-225(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Yanagawa T., Prado G.N., Paquet J.L., Bestian S., Cousins B., RA Navarro J.; RT "Novel pharmacological selectivity of the cloned murine B1 bradykinin RT receptor."; RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in CC chronic pain and inflammation. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in heart, liver and lung. CC -!- INDUCTION: By lipopolysaccharide (LPS) in heart, liver and lung CC five hours after treatment. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U47281; AAA99778.1; -; Genomic_DNA. DR EMBL; U44436; AAD00029.1; -; Genomic_DNA. DR PIR; JC4681; JC4681. DR Ensembl; ENSMUSG00000041347; Mus musculus. DR MGI; MGI:88144; Bdkrb1. DR InterPro; IPR001186; BK_rcpt_B1. DR InterPro; IPR000496; Brdyknn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF174; BK_receptorB1; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00425; BRADYKININR. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 334 B1 bradykinin receptor. FT /FTId=PRO_0000069184. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 62 1 (Potential). FT TOPO_DOM 63 80 Cytoplasmic (Potential). FT TRANSMEM 81 101 2 (Potential). FT TOPO_DOM 102 118 Extracellular (Potential). FT TRANSMEM 119 139 3 (Potential). FT TOPO_DOM 140 161 Cytoplasmic (Potential). FT TRANSMEM 162 182 4 (Potential). FT TOPO_DOM 183 214 Extracellular (Potential). FT TRANSMEM 215 235 5 (Potential). FT TOPO_DOM 236 258 Cytoplasmic (Potential). FT TRANSMEM 259 279 6 (Potential). FT TOPO_DOM 280 302 Extracellular (Potential). FT TRANSMEM 303 323 7 (Potential). FT TOPO_DOM 324 334 Cytoplasmic (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT CARBOHYD 192 192 N-linked (GlcNAc...) (Potential). FT DISULFID 117 196 By similarity. FT CONFLICT 216 216 L -> V (in Ref. 2). FT CONFLICT 260 260 L -> P (in Ref. 2). FT CONFLICT 263 265 VAS -> SSL (in Ref. 2). FT CONFLICT 331 334 LGTL -> WELYKRCTSLKNAVLPSRKELFQLSCWN (in FT Ref. 2). SQ SEQUENCE 334 AA; 37886 MW; 77C806203AC5C6CC CRC64; MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG LLGNLLVLSF FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW AENVGNRFNW PFGSDLCRVV SGVIKANLFI SIFLVVAISQ DRYRLLVYPM TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF LLRSVKVVPD LNISACILLF PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK EASRTRCGGP KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL // ID RL3R1_HUMAN STANDARD; PRT; 469 AA. AC Q9NSD7; DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 02-MAY-2006, entry version 35. DE Relaxin-3 receptor 1 (RLN3 receptor 1) (Relaxin family peptide DE receptor 3) (Somatostatin- and angiotensin-like peptide receptor) (G DE protein-coupled receptor SALPR) (GPCR135). GN Name=RXFP3; Synonyms=RLN3R1, SALPR; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain cortex; RX MEDLINE=20267860; PubMed=10806363; DOI=10.1016/S0378-1119(00)00123-2; RA Matsumoto M., Kamohara M., Sugimoto T., Hidaka K., Takasaki J., RA Saito T., Okada M., Yamaguchi T., Furuichi K.; RT "The novel G-protein coupled receptor SALPR shares sequence similarity RT with somatostatin and angiotensin receptors."; RL Gene 248:183-189(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE, AND FUNCTION. RX PubMed=14522968; DOI=10.1074/jbc.M308995200; RA Liu C., Eriste E., Sutton S., Chen J., Roland B., Kuei C., Farmer N., RA Joernvall H., Sillard R., Lovenberg T.W.; RT "Identification of relaxin-3/INSL7 as an endogenous ligand for the RT orphan G-protein coupled receptor GPCR135."; RL J. Biol. Chem. 278:50754-50764(2003). CC -!- FUNCTION: Receptor for relaxin-3. Binding of the ligand inhibit CC cAMP accumulation. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed predominantly in brain regions. CC Highest expression in substantia nigra and pituitary, followed by CC hippocampus, spinal cord, amygdala, caudate nucleus and corpus CC callosum, quite low level in cerebellum. In peripheral tissues, CC relatively high levels in adrenal glands, low levels in pancreas, CC salivary gland, placenta, mammary gland and testis. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; D88437; BAA93001.1; -; mRNA. DR EMBL; AY236541; AAO92063.1; -; Genomic_DNA. DR EMBL; AY394501; AAQ92315.1; -; mRNA. DR UniGene; Hs.170146; -. DR Ensembl; ENSG00000182631; Homo sapiens. DR HGNC; HGNC:24883; RXFP3. DR MIM; 609445; gene. DR LinkHub; Q9NSD7; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 469 Relaxin-3 receptor 1. FT /FTId=PRO_0000070104. FT TOPO_DOM 1 81 Extracellular (Potential). FT TRANSMEM 82 102 1 (Potential). FT TOPO_DOM 103 119 Cytoplasmic (Potential). FT TRANSMEM 120 140 2 (Potential). FT TOPO_DOM 141 156 Extracellular (Potential). FT TRANSMEM 157 177 3 (Potential). FT TOPO_DOM 178 215 Cytoplasmic (Potential). FT TRANSMEM 216 236 4 (Potential). FT TOPO_DOM 237 270 Extracellular (Potential). FT TRANSMEM 271 291 5 (Potential). FT TOPO_DOM 292 329 Cytoplasmic (Potential). FT TRANSMEM 330 350 6 (Potential). FT TOPO_DOM 351 356 Extracellular (Potential). FT TRANSMEM 357 377 7 (Potential). FT TOPO_DOM 378 469 Cytoplasmic (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CARBOHYD 40 40 N-linked (GlcNAc...) (Potential). FT DISULFID 155 247 By similarity. SQ SEQUENCE 469 AA; 51124 MW; 932E7B3001689F7B CRC64; MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW ELGLELPDGA PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL LVLYLMKSMQ GWRKSSINLF VTNLALTDFQ FVLTLPFWAV ENALDFKWPF GKAMCKIVSM VTSMNMYASV FFLTAMSVTR YHSVASALKS HRTRGHGRGD CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK VMGEELCLVR FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI LIKFNAVPFS QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL KSLLWRIASP SITSMRPFTA TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP GVVVYSGGRY DLLPSSSAY // ID APJ_HUMAN STANDARD; PRT; 380 AA. AC P35414; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 1. DT 18-APR-2006, entry version 50. DE Apelin receptor (G-protein coupled receptor APJ) (Angiotensin DE receptor-like 1) (HG11). GN Name=AGTRL1; Synonyms=APJ; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94124031; PubMed=8294032; DOI=10.1016/0378-1119(93)90495-O; RA O'Dowd B.F., Heiber M., Chan A., Heng H.H.Q., Tsui L.-C., RA Kennedy J.L., Shi X., Petronis A., George S.R., Nguyen T.; RT "A human gene that shows identity with the gene encoding the RT angiotensin receptor is located on chromosome 11."; RL Gene 136:355-360(1993). RN [2] RP NUCLEOTIDE SEQUENCE. RA Eggerickx D., Schurmans S., Vassart G., Parmentier M.; RT "Molecular cloning and tissue distribution of a human orphan receptor RT belonging to the G protein coupled receptors family."; RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for apelin coupled to G proteins that inhibit CC adenylate cyclase activity. Alternative coreceptor with CD4 for CC HIV-1 infection, maybe involved in the development of AIDS CC dementia. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Widely expressed in the brain, in glial cells, CC astrocytes and neuronal subpopulations, as well as in the spleen, CC thymus, ovary, small intestine and colon. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U03642; AAA18954.1; -; Unassigned_RNA. DR EMBL; X89271; CAA61546.1; -; mRNA. DR EMBL; BC032688; AAH32688.1; -; mRNA. DR PIR; I38435; I38435. DR UniGene; Hs.438311; -. DR Ensembl; ENSG00000134817; Homo sapiens. DR H-InvDB; HIX0009631; -. DR HGNC; HGNC:339; AGTRL1. DR MIM; 600052; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0004872; F:receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR InterPro; IPR003904; APJ_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF176; APJ_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01416; APJRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 380 Apelin receptor. FT /FTId=PRO_0000069173. FT TOPO_DOM 1 26 Extracellular (Potential). FT TRANSMEM 27 51 1 (Potential). FT TOPO_DOM 52 66 Cytoplasmic (Potential). FT TRANSMEM 67 91 2 (Potential). FT TOPO_DOM 92 100 Extracellular (Potential). FT TRANSMEM 101 125 3 (Potential). FT TOPO_DOM 126 144 Cytoplasmic (Potential). FT TRANSMEM 145 166 4 (Potential). FT TOPO_DOM 167 200 Extracellular (Potential). FT TRANSMEM 201 221 5 (Potential). FT TOPO_DOM 222 244 Cytoplasmic (Potential). FT TRANSMEM 245 271 6 (Potential). FT TOPO_DOM 272 284 Extracellular (Potential). FT TRANSMEM 285 308 7 (Potential). FT TOPO_DOM 309 380 Cytoplasmic (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 175 175 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 380 AA; 42660 MW; 78DB18BEA6D2B2E4 CRC64; MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK GGEQMHEKSI PYSQETLVVD // ID C3AR_HUMAN STANDARD; PRT; 482 AA. AC Q16581; O43771; Q92868; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 03-OCT-2003, sequence version 2. DT 18-APR-2006, entry version 57. DE C3a anaphylatoxin chemotactic receptor (C3a-R) (C3AR). GN Name=C3AR1; Synonyms=AZ3B, C3R1, HNFAG09; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=96180983; PubMed=8605247; DOI=10.1016/0167-4781(95)00209-X; RA Roglic A., Prossnitz E.R., Cavanagh S.L., Pan Z., Zou A., Ye R.D.; RT "cDNA cloning of a novel G protein-coupled receptor with a large RT extracellular loop structure."; RL Biochim. Biophys. Acta 1305:39-43(1996). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96350520; PubMed=8765043; RA Crass T., Raffetseder U., Martin U., Grove M., Klos A., Koehl J., RA Bautsch W.; RT "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) RT from differentiated U-937 cells."; RL Eur. J. Immunol. 26:1944-1950(1996). RN [3] RP SEQUENCE REVISION. RA Bautsch W.; RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96355342; PubMed=8702752; DOI=10.1074/jbc.271.34.20231; RA Ames R.S., Li Y., Sarau H.M., Nuthulaganti P., Foley J.J., Ellis C., RA Zeng Z., Su K., Jurewicz A.J., Hertzberg R.P., Bergsma D.J., Kumar C.; RT "Molecular cloning and characterization of the human anaphylatoxin C3a RT receptor."; RL J. Biol. Chem. 271:20231-20234(1996). RN [5] RP NUCLEOTIDE SEQUENCE. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-136. RA Rieder M.J., Daniels R.L., da Ponte S.H., Hastings N.C., Ahearn M.O., RA Rajkumar N., Yi Q., Nickerson D.A.; RT "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW- RT FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [9] RP SULFATION. RX PubMed=12871936; DOI=10.1074/jbc.M306061200; RA Gao J., Choe H., Bota D., Wright P.L., Gerard C., Gerard N.P.; RT "Sulfation of tyrosine 174 in the human C3a receptor is essential for RT binding of C3a anaphylatoxin."; RL J. Biol. Chem. 278:37902-37908(2003). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C3a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Widely expressed in several differentiated CC hematopoietic cell lines, in the lung, spleen, ovary, placenta, CC small intestine, throughout the brain, heart, and endothelial CC cells. Mostly expressed in lymphoid tissues. CC -!- PTM: Among the sulfation sites Tyr-174 is essential for binding of CC C3a anaphylatoxin. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U28488; AAC50374.1; -; mRNA. DR EMBL; Z73157; CAA97504.1; -; mRNA. DR EMBL; U62027; AAC50657.1; -; mRNA. DR EMBL; AB065870; BAC06088.1; -; Genomic_DNA. DR EMBL; AY268431; AAP23198.1; -; Genomic_DNA. DR EMBL; AY455929; AAR13862.1; -; Genomic_DNA. DR EMBL; BC020742; AAH20742.1; -; mRNA. DR PIR; S65766; S65766. DR UniGene; Hs.567242; -. DR Ensembl; ENSG00000171860; Homo sapiens. DR H-InvDB; HIX0010402; -. DR HGNC; HGNC:1319; C3AR1. DR MIM; 605246; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004943; F:C3a anaphylatoxin receptor activity; TAS. DR GO; GO:0004876; F:complement component C3a receptor activity; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; IGI. DR GO; GO:0004435; F:phosphoinositide phospholipase C activity; TAS. DR GO; GO:0008015; P:circulation; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; IGI. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0006954; P:inflammatory response; TAS. DR InterPro; IPR002234; Anphylx_rcpt. DR InterPro; IPR001644; C3A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR01060; C3ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Polymorphism; Receptor; Sensory transduction; Sulfation; Transducer; KW Transmembrane. FT CHAIN 1 482 C3a anaphylatoxin chemotactic receptor. FT /FTId=PRO_0000069202. FT TOPO_DOM 1 23 Extracellular (Potential). FT TRANSMEM 24 46 1 (Potential). FT TOPO_DOM 47 57 Cytoplasmic (Potential). FT TRANSMEM 58 80 2 (Potential). FT TOPO_DOM 81 96 Extracellular (Potential). FT TRANSMEM 97 118 3 (Potential). FT TOPO_DOM 119 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT TOPO_DOM 161 340 Extracellular (Potential). FT TRANSMEM 341 360 5 (Potential). FT TOPO_DOM 361 377 Cytoplasmic (Potential). FT TRANSMEM 378 400 6 (Potential). FT TOPO_DOM 401 417 Extracellular (Potential). FT TRANSMEM 418 438 7 (Potential). FT TOPO_DOM 439 482 Cytoplasmic (Potential). FT MOD_RES 174 174 Sulfotyrosine. FT MOD_RES 184 184 Sulfotyrosine. FT MOD_RES 318 318 Sulfotyrosine. FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 194 194 N-linked (GlcNAc...) (Potential). FT DISULFID 95 172 By similarity. FT VARIANT 136 136 V -> A (in dbSNP:11567806). FT /FTId=VAR_019164. FT CONFLICT 151 151 F -> C (in Ref. 4). FT CONFLICT 203 203 P -> R (in Ref. 1). SQ SEQUENCE 482 AA; 53864 MW; 287E219D98CED203 CRC64; MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI QGILEAAFSE ELTRSTHCPS NNVISERNST TV // ID C3AR_CAVPO STANDARD; PRT; 475 AA. AC O88680; Q9QWG9; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 07-MAR-2006, entry version 36. DE C3a anaphylatoxin chemotactic receptor (C3a-R) (C3AR). GN Name=C3AR1; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORM 1). RX MEDLINE=98391014; PubMed=9725198; RA Lienenklaus S., Ames R.S., Tornetta M.A., Sarau H.M., Foley J.J., RA Crass T., Sohns B., Raffetseder U., Grove M., Hoelzer A., Klos A., RA Koehl J., Bautsch W.; RT "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not RT the human C3a receptor."; RL J. Immunol. 161:2089-2093(1998). RN [2] RP NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY. RC STRAIN=Hartley; TISSUE=Spleen; RX MEDLINE=98414293; PubMed=9743361; RA Fukuoka Y., Ember J.A., Hugli T.E.; RT "Molecular cloning of two isoforms of the guinea pig C3a anaphylatoxin RT receptor: alternative splicing in the large extracellular loop."; RL J. Immunol. 161:2977-2984(1998). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C3a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=gpC3aR-L; CC IsoId=O88680-1; Sequence=Displayed; CC Name=2; Synonyms=gpC3aR-S; CC IsoId=O88680-2; Sequence=VSP_010628; CC -!- TISSUE SPECIFICITY: Expressed in the heart, kidney, lung, liver, CC peritoneal macrophages and spleen. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AJ006402; CAA07002.1; -; Genomic_DNA. DR EMBL; U86378; AAC36503.1; -; mRNA. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004943; F:C3a anaphylatoxin receptor activity; IDA. DR GO; GO:0006935; P:chemotaxis; NAS. DR InterPro; IPR002234; Anphylx_rcpt. DR InterPro; IPR001644; C3A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR01060; C3ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; Chemotaxis; G-protein coupled receptor; KW Glycoprotein; Membrane; Receptor; Sensory transduction; Sulfation; KW Transducer; Transmembrane. FT CHAIN 1 475 C3a anaphylatoxin chemotactic receptor. FT /FTId=PRO_0000069201. FT TOPO_DOM 1 23 Extracellular (Potential). FT TRANSMEM 24 46 1 (Potential). FT TOPO_DOM 47 57 Cytoplasmic (Potential). FT TRANSMEM 58 80 2 (Potential). FT TOPO_DOM 81 96 Extracellular (Potential). FT TRANSMEM 97 118 3 (Potential). FT TOPO_DOM 119 139 Cytoplasmic (Potential). FT TRANSMEM 140 160 4 (Potential). FT TOPO_DOM 161 331 Extracellular (Potential). FT TRANSMEM 332 351 5 (Potential). FT TOPO_DOM 352 368 Cytoplasmic (Potential). FT TRANSMEM 369 391 6 (Potential). FT TOPO_DOM 392 408 Extracellular (Potential). FT TRANSMEM 409 429 7 (Potential). FT TOPO_DOM 430 475 Cytoplasmic (Potential). FT MOD_RES 174 174 Sulfotyrosine (By similarity). FT MOD_RES 183 183 Sulfotyrosine (By similarity). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 168 168 N-linked (GlcNAc...) (Potential). FT CARBOHYD 273 273 N-linked (GlcNAc...) (Potential). FT CARBOHYD 292 292 N-linked (GlcNAc...) (Potential). FT DISULFID 95 172 By similarity. FT VARSPLIC 254 288 Missing (in isoform 2). FT /FTId=VSP_010628. FT CONFLICT 2 2 E -> D (in Ref. 2). FT CONFLICT 357 357 V -> A (in Ref. 2). SQ SEQUENCE 475 AA; 53570 MW; 0D6FFF5627A53330 CRC64; MESSSAETNS TGLHLEPQYQ PETILAMAIL GLTFVLGLPG NGLVLWVAGL KMRRTVNTVW FLHLTVADFV CCLSLPFSMA HLALRGYWPY GEILCKFIPT VIIFNMFASV FLLTAISLDR CLMVLKPIWC QNHRNVRTAC IICGCIWLVA FVLCIPVFVY RETFTLENHT ICTYNFSPGS FDYLDYAYDR DAWGYGTPDP IVQLPGEMEH RSDPSSFQTQ DGPWSVTTTL YSQTSQRPSE DSFHMDSAKL SGQGKYVDVV LPTNLCGLPM EENRTNTLHN AAFLSSDLDV SNATQKCLST PEPPQDFWDD LSPFTHEYRT PRLLKVITFT RLVVGFLLPM IIMVACYTLI IFRMRRVRVV KSWNKALHLA MVVVTIFLIC WAPYHVFGVL ILFINPESRV GAALLSWDHV SIALASANSC FNPFLYALLG RDLRKRVRQS MKGILEAAFS EDISKSTSFI QAKAFSEKHS LSTNV // ID FPRL1_MOUSE STANDARD; PRT; 351 AA. AC O08790; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1997, sequence version 1. DT 04-APR-2006, entry version 41. DE FMLP-related receptor I (FMLP-R-I) (Lipoxin A4 receptor) (LXA4 DE receptor). GN Name=Fprl1; Synonyms=Lxa4r; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Neutrophil, and Spleen; RX MEDLINE=97296322; PubMed=9151906; DOI=10.1084/jem.185.9.1693; RA Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., RA Serhan C.N.; RT "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues RT are potent inhibitors of acute inflammation: evidence for anti- RT inflammatory receptors."; RL J. Exp. Med. 185:1693-1704(1997). CC -!- FUNCTION: Low affinity receptor to N-formyl-methionyl peptides, CC which are powerful neutrophils chemotactic factors. Binding of CC FMLP to the receptor causes activation of neutrophils. This CC response is mediated via a G-protein that activates a CC phosphatidylinositol-calcium second messenger system. The CC activation of LXA4R could result in an anti-inflammatory outcome CC counteracting the actions of proinflammatory signals such as LTB4 CC (leukotriene B4). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed mostly in neutrophils, followed by CC spleen and lung. Expressed at very low levels in heart and liver. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U78299; AAC53198.1; -; mRNA. DR UniGene; Mm.378919; -. DR Ensembl; ENSMUSG00000052270; Mus musculus. DR MGI; MGI:1194495; Fprl1. DR GO; GO:0004872; F:receptor activity; IDA. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IDA. DR InterPro; IPR001644; C3A_anaphtx_rcpt. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01060; C3ANPHYLTXNR. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Sensory transduction; Transducer; Transmembrane. FT CHAIN 1 351 FMLP-related receptor I. FT /FTId=PRO_0000069453. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 50 1 (Potential). FT TOPO_DOM 51 61 Cytoplasmic (Potential). FT TRANSMEM 62 83 2 (Potential). FT TOPO_DOM 84 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT TOPO_DOM 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 162 4 (Potential). FT TOPO_DOM 163 205 Extracellular (Potential). FT TRANSMEM 206 226 5 (Potential). FT TOPO_DOM 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 266 6 (Potential). FT TOPO_DOM 267 286 Extracellular (Potential). FT TRANSMEM 287 306 7 (Potential). FT TOPO_DOM 307 351 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT DISULFID 98 176 Potential. SQ SEQUENCE 351 AA; 39549 MW; 1AF3B374B195E0CB CRC64; MESNYSIHLN GSEVVVYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV AGFRMPHTVT TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL VHIAVDVNLF GSVFLIAVIA LDRCICVLHP VWAQNHRTVS LARNVVVGSW IFALILTLPL FLFLTTVRDA RGDVHCRLSF VSWGNSVEER LNTAITFVTT RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF RVLTGVVASF FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA I // ID FPR1_HUMAN STANDARD; PRT; 350 AA. AC P21462; Q14939; Q7Z6A4; Q86U52; Q9NS48; DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1991, sequence version 1. DT 18-APR-2006, entry version 69. DE fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) DE (FPR) (N-formylpeptide chemoattractant receptor). GN Name=FPR1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=90267449; PubMed=2161213; RA Boulay F., Tardif M., Brouchon L., Vignais P.; RT "Synthesis and use of a novel N-formyl peptide derivative to isolate a RT human N-formyl peptide receptor cDNA."; RL Biochem. Biophys. Res. Commun. 168:1103-1109(1990). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=91105045; PubMed=2176894; RA Boulay F., Tardif M., Brouchon L., Vignais P.; RT "The human N-formylpeptide receptor. Characterization of two cDNA RT isolates and evidence for a new subfamily of G-protein-coupled RT receptors."; RL Biochemistry 29:11123-11133(1990). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=91286286; PubMed=1712023; RA Murphy P.M., McDermott D.; RT "Functional expression of the human formyl peptide receptor in Xenopus RT oocytes requires a complementary human factor."; RL J. Biol. Chem. 266:12560-12567(1991). RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92307681; PubMed=1612600; RA Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.; RT "Mapping of genes for the human C5a receptor (C5AR), human FMLP RT receptor (FPR), and two FMLP receptor homologue orphan receptors RT (FPRH1, FPRH2) to chromosome 19."; RL Genomics 13:437-440(1992). RN [5] RP NUCLEOTIDE SEQUENCE. RA Perez H.D.; RL Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94040825; PubMed=8224916; DOI=10.1016/0378-1119(93)90653-K; RA Murphy P.M., Tiffany H.L., McDermott D., Ahuja S.K.; RT "Sequence and organization of the human N-formyl peptide receptor- RT encoding gene."; RL Gene 133:285-290(1993). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-101; LYS-192 RP AND GLU-346. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE, AND VARIANTS VAL-101 AND GLU-346. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [11] RP NUCLEOTIDE SEQUENCE OF 1-5. RC TISSUE=Bone marrow; RX PubMed=1445895; RA Perez H.D., Holmes R., Kelly E., McClary J., Chou Q., Andrews W.H.; RT "Cloning of the gene coding for a human receptor for formyl peptides. RT Characterization of a promoter region and evidence for polymorphic RT expression."; RL Biochemistry 31:11595-11599(1992). RN [12] RP PHOSPHORYLATION SITES SER-328; THR-329; THR-331; SER-332; THR-334; RP THR-336; SER-338 AND THR-339. RX MEDLINE=99445530; PubMed=10514456; DOI=10.1074/jbc.274.42.29791; RA Maestes D.C., Potter R.M., Prossnitz E.R.; RT "Differential phosphorylation paradigms dictate desensitization and RT internalization of the N-formyl peptide receptor."; RL J. Biol. Chem. 274:29791-29795(1999). CC -!- FUNCTION: High affinity receptor for N-formyl-methionyl peptides, CC which are powerful neutrophils chemotactic factors. Binding of CC FMLP to the receptor causes activation of neutrophils. This CC response is mediated via a G-protein that activates a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Neutrophils. CC -!- PTM: Phosphorylated; which is necessary for desensitization. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M37128; AAA36362.1; -; mRNA. DR EMBL; M60626; AAA35846.1; -; mRNA. DR EMBL; M60627; AAA35847.1; -; mRNA. DR EMBL; L10820; AAA16863.1; -; Unassigned_DNA. DR EMBL; AY301273; AAP58403.1; -; Genomic_DNA. DR EMBL; BT007429; AAP36097.1; -; mRNA. DR EMBL; AC018755; AAF87842.1; -; Genomic_DNA. DR EMBL; BC005315; AAH05315.1; -; mRNA. DR EMBL; S49810; AAD14906.1; -; mRNA. DR PIR; JC2014; A42009. DR UniGene; Hs.753; -. DR Ensembl; ENSG00000171051; Homo sapiens. DR H-InvDB; HIX0015389; -. DR HGNC; HGNC:3826; FPR1. DR MIM; 136537; gene. DR GO; GO:0005768; C:endosome; TAS. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004982; F:N-formyl peptide receptor activity; IDA. DR GO; GO:0004872; F:receptor activity; TAS. DR GO; GO:0000187; P:activation of MAPK activity; TAS. DR GO; GO:0006928; P:cell motility; TAS. DR GO; GO:0006935; P:chemotaxis; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0007188; P:G-protein signaling, coupled to cAMP nucleo...; TAS. DR GO; GO:0007263; P:nitric oxide mediated signal transduction; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Polymorphism; Receptor; Sensory transduction; KW Transducer; Transmembrane. FT CHAIN 1 350 fMet-Leu-Phe receptor. FT /FTId=PRO_0000069444. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 50 1 (Potential). FT TOPO_DOM 51 61 Cytoplasmic (Potential). FT TRANSMEM 62 83 2 (Potential). FT TOPO_DOM 84 100 Extracellular (Potential). FT TRANSMEM 101 121 3 (Potential). FT TOPO_DOM 122 140 Cytoplasmic (Potential). FT TRANSMEM 141 162 4 (Potential). FT TOPO_DOM 163 205 Extracellular (Potential). FT TRANSMEM 206 226 5 (Potential). FT TOPO_DOM 227 242 Cytoplasmic (Potential). FT TRANSMEM 243 266 6 (Potential). FT TOPO_DOM 267 285 Extracellular (Potential). FT TRANSMEM 286 305 7 (Potential). FT TOPO_DOM 306 350 Cytoplasmic (Potential). FT MOD_RES 328 328 Phosphoserine (Potential). FT MOD_RES 329 329 Phosphothreonine (Potential). FT MOD_RES 331 331 Phosphothreonine (Potential). FT MOD_RES 332 332 Phosphoserine (Potential). FT MOD_RES 334 334 Phosphothreonine (Potential). FT MOD_RES 336 336 Phosphothreonine (Potential). FT MOD_RES 338 338 Phosphoserine (Potential). FT MOD_RES 339 339 Phosphothreonine (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT DISULFID 98 176 Potential. FT VARIANT 101 101 L -> V. FT /FTId=VAR_003476. FT VARIANT 192 192 N -> K. FT /FTId=VAR_003477. FT VARIANT 346 346 A -> E. FT /FTId=VAR_003478. FT CONFLICT 11 11 I -> T (in Ref. 7). FT CONFLICT 238 238 R -> P (in Ref. 1). SQ SEQUENCE 350 AA; 38401 MW; 0663EFF8267E2BD1 CRC64; METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV AGFRMTHTVT TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF LFTIVDINLF GSVFLIALIA LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW VMALLLTLPV IIRVTTVPGK TGTVACTFNF SPWTNDPKER INVAVAMLTV RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL RVLSFVAAAF FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVALQAK // ID GPR33_PANPA STANDARD; PRT; 333 AA. AC Q49SQ2; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 13-SEP-2005, sequence version 1. DT 18-APR-2006, entry version 10. DE Probable G-protein coupled receptor 33. GN Name=GPR33; OS Pan paniscus (Pygmy chimpanzee) (Bonobo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9597; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=15987686; DOI=10.1074/jbc.M503586200; RA Roempler H., Schulz A., Pitra C., Coop G., Przeworski M., Paeaebo S., RA Schoeneberg T.; RT "The rise and fall of the chemoattractant receptor GPR33."; RL J. Biol. Chem. 280:31068-31075(2005). CC -!- FUNCTION: Orphan receptor; could be a chemoattractant receptor. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY493997; AAR98753.1; -; Genomic_DNA. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 333 Probable G-protein coupled receptor 33. FT /FTId=PRO_0000069555. FT TOPO_DOM 1 30 Extracellular (Potential). FT TRANSMEM 31 53 1 (Potential). FT TOPO_DOM 54 64 Cytoplasmic (Potential). FT TRANSMEM 65 86 2 (Potential). FT TOPO_DOM 87 103 Extracellular (Potential). FT TRANSMEM 104 124 3 (Potential). FT TOPO_DOM 125 143 Cytoplasmic (Potential). FT TRANSMEM 144 165 4 (Potential). FT TOPO_DOM 166 209 Extracellular (Potential). FT TRANSMEM 210 230 5 (Potential). FT TOPO_DOM 231 246 Cytoplasmic (Potential). FT TRANSMEM 247 268 6 (Potential). FT TOPO_DOM 269 283 Extracellular (Potential). FT TRANSMEM 284 303 7 (Potential). FT TOPO_DOM 304 333 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT CARBOHYD 272 272 N-linked (GlcNAc...) (Potential). FT DISULFID 101 179 Potential. SQ SEQUENCE 333 AA; 38287 MW; DFF39F6D99B7259A CRC64; MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY LWVLRFKMKQ TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRQTH HDRKGKVTCQ NNYAVSTNWE SKEMQALRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS SKPFKVMMTA IISFFVCWMP YHIHQGLLLT MNQSLLLELT LILTVLTTSF NTIFSPTLYL FVGENFKKVF KKSILALFES TFSEDSSVER TQT // ID CML1_MOUSE STANDARD; PRT; 371 AA. AC P97468; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 18-APR-2006, entry version 45. DE Chemokine receptor-like 1 (G-protein coupled receptor DEZ). GN Name=Cmklr1; Synonyms=Dez, Gpcr27; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=97289630; PubMed=9144535; DOI=10.1006/bbrc.1997.6455; RA Methner A., Hermey G., Schinke B., Hermans-Borgmeyer I.; RT "A novel G protein-coupled receptor with homology to neuropeptide and RT chemoattractant receptors expressed during bone development."; RL Biochem. Biophys. Res. Commun. 233:336-342(1997). CC -!- FUNCTION: Orphan receptor. Could be a chemotactic peptide CC receptor. May have a function in bone metabolism. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- DEVELOPMENTAL STAGE: Expressed during bone development and in CC adult parathyroid glands. Expressed at day E11 in the caudal part CC of the tongue and the umbilical cord and the expression in the CC tongue was maintained throughout adulthood. Expression increases CC in bone and cartilaginous forming zones of embryo up to stage CC E14.5 and at E16.5 expression is seen in the lung. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U79525; AAB53789.1; -; mRNA. DR PIR; JC5498; JC5498. DR UniGene; Mm.5196; -. DR Ensembl; ENSMUSG00000042190; Mus musculus. DR MGI; MGI:109603; Cmklr1. DR InterPro; IPR001274; C5A_anaphtx_rcpt. DR InterPro; IPR002258; DEZorph_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF127; DEZorph_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR01126; DEZORPHANR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 371 Chemokine receptor-like 1. FT /FTId=PRO_0000069308. FT TOPO_DOM 1 39 Extracellular (Potential). FT TRANSMEM 40 62 1 (Potential). FT TOPO_DOM 63 73 Cytoplasmic (Potential). FT TRANSMEM 74 95 2 (Potential). FT TOPO_DOM 96 112 Extracellular (Potential). FT TRANSMEM 113 133 3 (Potential). FT TOPO_DOM 134 152 Cytoplasmic (Potential). FT TRANSMEM 153 174 4 (Potential). FT TOPO_DOM 175 222 Extracellular (Potential). FT TRANSMEM 223 243 5 (Potential). FT TOPO_DOM 244 259 Cytoplasmic (Potential). FT TRANSMEM 260 280 6 (Potential). FT TOPO_DOM 281 298 Extracellular (Potential). FT TRANSMEM 299 318 7 (Potential). FT TOPO_DOM 319 371 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 190 190 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 Potential. SQ SEQUENCE 371 AA; 41815 MW; CDBE19305244C0B3 CRC64; MEYDAYNDSG IYDDEYSDGF GYFVDLEEAS PWEAKVAPVF LVVIYSLVCF LGLLGNGLVI VIATFKMKKT VNTVWFVNLA VADFLFNIFL PMHITYAAMD YHWVFGKAMC KISNFLLSHN MYTSVFLLTV ISFDRCISVL LPVWSQNHRS IRLAYMTCSA VWVLAFFLSS PSLVFRDTAN IHGKITCFNN FSLAAPESSP HPAHSQVVST GYSRHVAVTV TRFLCGFLIP VFIITACYLT IVFKLQRNRL AKNKKPFKII ITIIITFFLC WCPYHTLYLL ELHHTAVPSS VFSLGLPLAT AVAIANSCMN PILYVFMGHD FRKFKVALFS RLANALSEDT GPSSYPSHRS FTKMSSLNEK ASVNEKETST L // ID C5AR_CANFA STANDARD; PRT; 352 AA. AC P30992; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 02-MAY-2006, entry version 45. DE C5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (CD88 antigen). GN Name=C5AR1; Synonyms=C5R1; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=93111969; PubMed=1472004; RA Perret J.J., Raspe E., Vassart G., Parmentier M.; RT "Cloning and functional expression of the canine anaphylatoxin C5a RT receptor. Evidence for high interspecies variability."; RL Biochem. J. 288:911-917(1992). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C5a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Sulfation plays a critical role in the association of C5aR CC with C5a, but no significant role in the ability of the receptor CC to transduce a signal and mobilize calcium in response to a small CC peptide agonist (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X65860; CAA46690.1; -; mRNA. DR PIR; S27357; S27357. DR UniGene; Cfa.3834; -. DR Ensembl; ENSCAFG00000004175; Canis familiaris. DR InterPro; IPR002234; Anphylx_rcpt. DR InterPro; IPR001274; C5A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Membrane; Phosphorylation; KW Receptor; Sensory transduction; Sulfation; Transducer; Transmembrane. FT CHAIN 1 352 C5a anaphylatoxin chemotactic receptor. FT /FTId=PRO_0000069206. FT TOPO_DOM 1 38 Extracellular (Potential). FT TRANSMEM 39 61 1 (Potential). FT TOPO_DOM 62 72 Cytoplasmic (Potential). FT TRANSMEM 73 95 2 (Potential). FT TOPO_DOM 96 111 Extracellular (Potential). FT TRANSMEM 112 133 3 (Potential). FT TOPO_DOM 134 154 Cytoplasmic (Potential). FT TRANSMEM 155 175 4 (Potential). FT TOPO_DOM 176 202 Extracellular (Potential). FT TRANSMEM 203 228 5 (Potential). FT TOPO_DOM 229 244 Cytoplasmic (Potential). FT TRANSMEM 245 267 6 (Potential). FT TOPO_DOM 268 284 Extracellular (Potential). FT TRANSMEM 285 305 7 (Potential). FT TOPO_DOM 306 352 Cytoplasmic (Potential). FT MOD_RES 11 11 Sulfotyrosine (By similarity). FT MOD_RES 14 14 Sulfotyrosine (By similarity). FT MOD_RES 316 316 Phosphoserine (By similarity). FT MOD_RES 329 329 Phosphoserine (By similarity). FT MOD_RES 334 334 Phosphoserine (By similarity). FT MOD_RES 336 336 Phosphoserine (By similarity). FT MOD_RES 340 340 Phosphoserine (By similarity). FT DISULFID 110 189 By similarity. SQ SEQUENCE 352 AA; 39213 MW; A31F8F1F8D02F135 CRC64; MASMNFSPPE YPDYGTATLD PNIFVDESLN TPKLSVPDMI ALVIFVMVFL VGVPGNFLVV WVTGFEVRRT INAIWFLNLA VADLLSCLAL PILFSSIVQQ GYWPFGNAAC RILPSLILLN MYASILLLTT ISADRFVLVF NPIWCQNYRG PQLAWAACSV AWAVALLLTV PSFIFRGVHT EYFPFWMTCG VDYSGVGVLV ERGVAILRLL MGFLGPLVIL SICYTFLLIR TWSRKATRST KTLKVVVAVV VSFFVLWLPY QVTGMMMALF YKHSESFRRV SRLDSLCVAV AYINCCINPI IYVLAAQGFH SRFLKSLPAR LRQVLAEESV GRDSKSITLS TVDTPAQKSQ GV // ID C5AR_MOUSE STANDARD; PRT; 347 AA. AC P30993; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 18-APR-2006, entry version 49. DE C5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (CD88 antigen). GN Name=C5ar1; Synonyms=C5ar, C5r1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=93017861; PubMed=1401897; RA Gerard C., Bao L., Orozco O., Pearson M., Kunz D., Gerard N.P.; RT "Structural diversity in the extracellular faces of peptidergic G- RT protein-coupled receptors. Molecular cloning of the mouse C5a RT anaphylatoxin receptor."; RL J. Immunol. 149:2600-2606(1992). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C5a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Sulfation plays a critical role in the association of C5aR CC with C5a, but no significant role in the ability of the receptor CC to transduce a signal and mobilize calcium in response to a small CC peptide agonist (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; S46665; AAB97774.1; ALT_SEQ; Genomic_DNA. DR EMBL; S50577; AAB97774.1; JOINED; Genomic_DNA. DR UniGene; Mm.247623; -. DR Ensembl; ENSMUSG00000049130; Mus musculus. DR MGI; MGI:88232; C5ar1. DR InterPro; IPR002234; Anphylx_rcpt. DR InterPro; IPR001274; C5A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Receptor; Sensory transduction; Sulfation; KW Transducer; Transmembrane. FT CHAIN 1 347 C5a anaphylatoxin chemotactic receptor. FT /FTId=PRO_0000069211. FT TOPO_DOM 1 33 Extracellular (Potential). FT TRANSMEM 34 56 1 (Potential). FT TOPO_DOM 57 67 Cytoplasmic (Potential). FT TRANSMEM 68 90 2 (Potential). FT TOPO_DOM 91 106 Extracellular (Potential). FT TRANSMEM 107 128 3 (Potential). FT TOPO_DOM 129 149 Cytoplasmic (Potential). FT TRANSMEM 150 170 4 (Potential). FT TOPO_DOM 171 197 Extracellular (Potential). FT TRANSMEM 198 223 5 (Potential). FT TOPO_DOM 224 239 Cytoplasmic (Potential). FT TRANSMEM 240 262 6 (Potential). FT TOPO_DOM 263 279 Extracellular (Potential). FT TRANSMEM 280 300 7 (Potential). FT TOPO_DOM 301 347 Cytoplasmic (Potential). FT MOD_RES 9 9 Sulfotyrosine (By similarity). FT MOD_RES 12 12 Sulfotyrosine (By similarity). FT MOD_RES 311 311 Phosphoserine (By similarity). FT MOD_RES 314 314 Phosphoserine (By similarity). FT MOD_RES 324 324 Phosphoserine (By similarity). FT MOD_RES 329 329 Phosphoserine (By similarity). FT MOD_RES 335 335 Phosphoserine (By similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT DISULFID 105 184 By similarity. SQ SEQUENCE 347 AA; 38510 MW; 3C614DAD0DD0F53B CRC64; MNSSFEINYD HYGTMDPNIP ADGIHLPKRQ PGDVAALIIY SVVFLVGVPG NALVVWVTAF EPDGPSNAIW FLNLAVADLL SCLAMPVLFT TVLNHNYWYF DATACIVLPS LILLNMYASI LLLATISADR FLLVFKPIWC QKVRGTGLAW MACGVAWVLA LLLTIPSFVY REAYKDFYSE HTVCGINYGG GSFPKEKAVA ILRLMVGFVL PLLTLNICYT FLLLRTWSRK ATRSTKTLKV VMAVVICFFI FWLPYQVTGV MIAWLPPSSP TLKRVEKLNS LCVSLAYINC CVNPIIYVMA GQGFHGRLLR SLPSIIRNAL SEDSVGRDSK TFTPSTDDTS PRKSQAV // ID PAR2_MOUSE STANDARD; PRT; 399 AA. AC P55086; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 18-APR-2006, entry version 49. DE Proteinase-activated receptor 2 precursor (PAR-2) (Thrombin receptor- DE like 1) (Coagulation factor II receptor-like 1) (G-protein coupled DE receptor 11). GN Name=F2rl1; Synonyms=Gpcr11, Gpr11, Par2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=95197620; PubMed=7890726; DOI=10.1074/jbc.270.11.5950; RA Nystedt S., Larsson A.-K., Aaberg H., Sundelin J.; RT "The mouse proteinase-activated receptor-2 cDNA and gene. Molecular RT cloning and functional expression."; RL J. Biol. Chem. 270:5950-5955(1995). CC -!- FUNCTION: Receptor for trypsin and trypsin-like enzymes coupled to CC G proteins that stimulate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: A proteolytic cleavage generates a new N-terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Z48043; CAA88097.1; -; mRNA. DR PIR; I48705; I48705. DR UniGene; Mm.1614; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSMUSG00000021678; Mus musculus. DR MGI; MGI:101910; F2rl1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR002281; Pro_rcpt_2. DR InterPro; IPR003912; Protea_act_rcpt. DR PANTHER; PTHR19264:SF138; Pro_receptor2; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01428; PROTEASEAR. DR PRINTS; PR01152; PROTEASEAR2. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Signal; KW Transducer; Transmembrane. FT SIGNAL 1 25 Potential. FT PROPEP 26 38 Removed for receptor activation (By FT similarity). FT /FTId=PRO_0000012752. FT CHAIN 39 399 Proteinase-activated receptor 2. FT /FTId=PRO_0000012753. FT TOPO_DOM 39 77 Extracellular (Potential). FT TRANSMEM 78 103 1 (Potential). FT TOPO_DOM 104 112 Cytoplasmic (Potential). FT TRANSMEM 113 132 2 (Potential). FT TOPO_DOM 133 151 Extracellular (Potential). FT TRANSMEM 152 173 3 (Potential). FT TOPO_DOM 174 192 Cytoplasmic (Potential). FT TRANSMEM 193 213 4 (Potential). FT TOPO_DOM 214 243 Extracellular (Potential). FT TRANSMEM 244 262 5 (Potential). FT TOPO_DOM 263 287 Cytoplasmic (Potential). FT TRANSMEM 288 310 6 (Potential). FT TOPO_DOM 311 325 Extracellular (Potential). FT TRANSMEM 326 349 7 (Potential). FT TOPO_DOM 350 399 Cytoplasmic (Potential). FT COMPBIAS 385 394 Poly-Ser. FT SITE 38 39 Cleavage (by trypsin) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT CARBOHYD 224 224 N-linked (GlcNAc...) (Potential). FT DISULFID 150 228 By similarity. SQ SEQUENCE 399 AA; 44752 MW; A93749425ED0B194 CRC64; MRSLSLAWLL GGITLLAASV SCSRTENLAP GRNNSKGRSL IGRLETQPPI TGKGVPVEPG FSIDEFSASI LTGKLTTVFL PVVYIIVFVI GLPSNGMALW IFLFRTKKKH PAVIYMANLA LADLLSVIWF PLKISYHLHG NNWVYGEALC KVLIGFFYGN MYCSILFMTC LSVQRYWVIV NPMGHPRKKA NIAVGVSLAI WLLIFLVTIP LYVMKQTIYI PALNITTCHD VLPEEVLVGD MFNYFLSLAI GVFLFPALLT ASAYVLMIKT LRSSAMDEHS EKKRQRAIRL IITVLAMYFI CFAPSNLLLV VHYFLIKTQR QSHVYALYLV ALCLSTLNSC IDPFVYYFVS KDFRDHARNA LLCRSVRTVN RMQISLSSNK FSRKSGSYSS SSTSVKTSY // ID PAR1_XENLA STANDARD; PRT; 420 AA. AC P47749; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 04-APR-2006, entry version 42. DE Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor). GN Name=f2r; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=94195429; PubMed=8145852; DOI=10.1038/368648a0; RA Gerszten R.E., Chen J., Ishii M., Ishii K., Nanevicz T., Turck C.W., RA Vu T.-K.H., Coughlin S.R.; RT "Specificity of the thrombin receptor for agonist peptide is defined RT by its extracellular surface."; RL Nature 368:648-651(1994). CC -!- FUNCTION: High affinity receptor for activated thrombin coupled to CC G proteins that stimulate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: A proteolytic cleavage generates a new N-terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U09632; AAA18498.1; -; mRNA. DR PIR; I51667; I51667. DR UniGene; Xl.974; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003912; Protea_act_rcpt. DR InterPro; IPR000935; Thrmbn_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01428; PROTEASEAR. DR PRINTS; PR00908; THROMBINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Blood coagulation; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Signal; Transducer; Transmembrane. FT SIGNAL 1 20 Potential. FT PROPEP 21 42 Removed for receptor activation. FT /FTId=PRO_0000012748. FT CHAIN 43 420 Proteinase-activated receptor 1. FT /FTId=PRO_0000012749. FT TOPO_DOM 43 101 Extracellular (Potential). FT TRANSMEM 102 127 1 (Potential). FT TOPO_DOM 128 136 Cytoplasmic (Potential). FT TRANSMEM 137 156 2 (Potential). FT TOPO_DOM 157 175 Extracellular (Potential). FT TRANSMEM 176 197 3 (Potential). FT TOPO_DOM 198 217 Cytoplasmic (Potential). FT TRANSMEM 218 238 4 (Potential). FT TOPO_DOM 239 267 Extracellular (Potential). FT TRANSMEM 268 287 5 (Potential). FT TOPO_DOM 288 310 Cytoplasmic (Potential). FT TRANSMEM 311 333 6 (Potential). FT TOPO_DOM 334 345 Extracellular (Potential). FT TRANSMEM 346 369 7 (Potential). FT TOPO_DOM 370 420 Cytoplasmic (Potential). FT COMPBIAS 295 300 Poly-Ser. FT SITE 42 43 Cleavage (by thrombin). FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). FT CARBOHYD 86 86 N-linked (GlcNAc...) (Potential). FT DISULFID 174 253 By similarity. FT MUTAGEN 42 42 K->A: Lack of activation by thrombin. SQ SEQUENCE 420 AA; 47436 MW; D5163F56AFE12372 CRC64; MMELRVLLLL LLLTLLGAMG SLCLANSDTQ AKGAHSNNMT IKTFRIFDDS ESEFEEIPWD ELDESGEGSG DQAPVSRSAR KPIRRNITKE AEQYLSSQWL TKFVPSLYTV VFIVGLPLNL LAIIIFLFKM KVRKPAVVYM LNLAIADVFF VSVLPFKIAY HLSGNDWLFG PGMCRIVTAI FYCNMYCSVL LIASISVDRF LAVVYPMHSL SWRTMSRAYM ACSFIWLISI ASTIPLLVTE QTQKIPRLDI TTCHDVLDLK DLKDFYIYYF SSFCLLFFFV PFIITTICYI GIIRSLSSSS IENSCKKTRA LFLAVVVLCV FIICFGPTNV LFLTHYLQEA NEFLYFAYIL SACVGSVSCC LDPLIYYYAS SQCQRYLYSL LCCRKVSEPG SSTGQLMSTA MKNDNCSTNA KSSIYKKLLA // ID PAR3_HUMAN STANDARD; PRT; 374 AA. AC O00254; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1997, sequence version 1. DT 18-APR-2006, entry version 53. DE Proteinase-activated receptor 3 precursor (PAR-3) (Thrombin receptor- DE like 2) (Coagulation factor II receptor-like 2). GN Name=F2RL2; Synonyms=PAR3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE, AND MUTAGENESIS OF THR-39 AND PHE-40. RX MEDLINE=97242411; PubMed=9087410; DOI=10.1038/386502a0; RA Ishihara H., Connolly A.J., Zeng D., Kahn M.L., Zheng Y.-W., RA Timmons C., Tram T., Coughlin S.R.; RT "Protease-activated receptor 3 is a second thrombin receptor in RT humans."; RL Nature 386:502-506(1997). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-15; VAL-177 AND RP ASP-250. RA Rieder M.J., Carrington D.P., Chung M.-W., Lee K.L., Poel C.L., Yi Q., RA Nickerson D.A.; RT "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW- RT FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP TISSUE SPECIFICITY. RX MEDLINE=98279023; PubMed=9614115; DOI=10.1074/jbc.273.24.15061; RA Schmidt V.A., Nierman W.C., Maglott D.R., Cupit L.D., Moskowitz K.A., RA Wainer J.A., Bahou W.F.; RT "The human proteinase-activated receptor-3 (PAR-3) gene. RT Identification within a PAR gene cluster and characterization in RT vascular endothelial cells and platelets."; RL J. Biol. Chem. 273:15061-15068(1998). RN [4] RP FUNCTION. RX MEDLINE=99178892; PubMed=10079109; RA Kahn M.L., Nakanishi-Matsui M., Shapiro M.J., Ishihara H., RA Coughlin S.R.; RT "Protease-activated receptors 1 and 4 mediate activation of human RT platelets by thrombin."; RL J. Clin. Invest. 103:879-887(1999). CC -!- FUNCTION: Receptor for activated thrombin coupled to G proteins CC that stimulate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Highest expression in the megakaryocytes of CC the bone marrow, lower in mature megakaryocytes, in platelets and CC in a variety of other tissues such as heart and gut. CC -!- PTM: A proteolytic cleavage generates a new N-terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U92971; AAC51218.1; -; mRNA. DR EMBL; AF374726; AAK51564.1; -; Genomic_DNA. DR UniGene; Hs.42502; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSG00000164220; Homo sapiens. DR HGNC; HGNC:3539; F2RL2. DR MIM; 601919; gene. DR Reactome; O00254; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004435; F:phosphoinositide phospholipase C activity; TAS. DR GO; GO:0015057; F:thrombin receptor activity; TAS. DR GO; GO:0007596; P:blood coagulation; TAS. DR GO; GO:0009611; P:response to wounding; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003943; Prot_act_rcpt_3. DR InterPro; IPR003912; Protea_act_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01428; PROTEASEAR. DR PRINTS; PR01429; PROTEASEAR3. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Blood coagulation; G-protein coupled receptor; Glycoprotein; Membrane; KW Polymorphism; Receptor; Signal; Transducer; Transmembrane. FT SIGNAL 1 21 Potential. FT PROPEP 22 38 Removed for receptor activation (By FT similarity). FT /FTId=PRO_0000012756. FT CHAIN 39 374 Proteinase-activated receptor 3. FT /FTId=PRO_0000012757. FT TOPO_DOM 39 94 Extracellular (Potential). FT TRANSMEM 95 120 1 (Potential). FT TOPO_DOM 121 128 Cytoplasmic (Potential). FT TRANSMEM 129 148 2 (Potential). FT TOPO_DOM 149 167 Extracellular (Potential). FT TRANSMEM 168 189 3 (Potential). FT TOPO_DOM 190 206 Cytoplasmic (Potential). FT TRANSMEM 207 230 4 (Potential). FT TOPO_DOM 231 260 Extracellular (Potential). FT TRANSMEM 261 280 5 (Potential). FT TOPO_DOM 281 297 Cytoplasmic (Potential). FT TRANSMEM 298 322 6 (Potential). FT TOPO_DOM 323 336 Extracellular (Potential). FT TRANSMEM 337 361 7 (Potential). FT TOPO_DOM 362 374 Cytoplasmic (Potential). FT SITE 38 39 Cleavage (by thrombin) (By similarity). FT CARBOHYD 25 25 N-linked (GlcNAc...) (Potential). FT CARBOHYD 82 82 N-linked (GlcNAc...) (Potential). FT CARBOHYD 331 331 N-linked (GlcNAc...) (Potential). FT DISULFID 166 245 By similarity. FT VARIANT 15 15 L -> S (in dbSNP:2069649). FT /FTId=VAR_012849. FT VARIANT 177 177 M -> V (in dbSNP:2069700). FT /FTId=VAR_012850. FT VARIANT 250 250 N -> D (in dbSNP:2069683). FT /FTId=VAR_012851. FT MUTAGEN 39 39 T->P: No proteolytic cleavage by FT thrombin. FT MUTAGEN 40 40 F->A: Altered signal upon thrombin FT cleavage. SQ SEQUENCE 374 AA; 42508 MW; C45C15A695DD1ABB CRC64; MKALIFAAAG LLLLLPTFCQ SGMENDTNNL AKPTLPIKTF RGAPPNSFEE FPFSALEGWT GATITVKIKC PEESASHLHV KNATMGYLTS SLSTKLIPAI YLLVFVVGVP ANAVTLWMLF FRTRSICTTV FYTNLAIADF LFCVTLPFKI AYHLNGNNWV FGEVLCRATT VIFYGNMYCS ILLLACISIN RYLAIVHPFT YRGLPKHTYA LVTCGLVWAT VFLYMLPFFI LKQEYYLVQP DITTCHDVHN TCESSSPFQL YYFISLAFFG FLIPFVLIIY CYAAIIRTLN AYDHRWLWYV KASLLILVIF TICFAPSNII LIIHHANYYY NNTDGLYFIY LIALCLGSLN SCLDPFLYFL MSKTRNHSTA YLTK // ID PAR4_HUMAN STANDARD; PRT; 385 AA. AC Q96RI0; O76067; Q6DK42; DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot. DT 27-MAR-2002, sequence version 2. DT 18-APR-2006, entry version 39. DE Proteinase-activated receptor 4 precursor (PAR-4) (Thrombin receptor- DE like 3) (Coagulation factor II receptor-like 3). GN Name=F2RL3; Synonyms=PAR4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=98389762; PubMed=9722561; DOI=10.1074/jbc.273.36.23290; RA Kahn M.L., Hammes S.R., Botka C., Coughlin S.R.; RT "Gene and locus structure and chromosomal localization of the RT protease-activated receptor gene family."; RL J. Biol. Chem. 273:23290-23296(1998). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=98379991; PubMed=9716134; DOI=10.1038/29325; RA Kahn M.L., Zheng Y.-W., Huang W., Bigornia V., Zeng D., Moff S., RA Farese R.V. Jr., Tam C., Coughlin S.R.; RT "A dual thrombin receptor system for platelet activation."; RL Nature 394:690-694(1998). RN [3] RP NUCLEOTIDE SEQUENCE, AND MUTAGENESIS OF ARG-47 AND ARG-68. RC TISSUE=Lymphoma; RX MEDLINE=98283984; PubMed=9618465; DOI=10.1073/pnas.95.12.6642; RA Xu W.-F., Andersen H., Whitmore T.E., Presnell S.R., Yee D.P., RA Ching A., Gilbert T., Davie E.W., Foster D.C.; RT "Cloning and characterization of human protease-activated receptor RT 4."; RL Proc. Natl. Acad. Sci. U.S.A. 95:6642-6646(1998). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RA King M.M., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-296 AND LEU-310. RA Rieder M.J., Carrington D.P., Chung M.-W., Lee K.L., Poel C.L., Yi Q., RA Nickerson D.A.; RT "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW- RT FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP FUNCTION. RX MEDLINE=99178892; PubMed=10079109; RA Kahn M.L., Nakanishi-Matsui M., Shapiro M.J., Ishihara H., RA Coughlin S.R.; RT "Protease-activated receptors 1 and 4 mediate activation of human RT platelets by thrombin."; RL J. Clin. Invest. 103:879-887(1999). CC -!- FUNCTION: Receptor for activated thrombin or trypsin coupled to G CC proteins that stimulate phosphoinositide hydrolysis. May play a CC role in platelets activation. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in lung, CC pancreas, thyroid, testis and small intestine. Not expressed in CC brain, kidney, spinal cord and peripheral blood leukocytes. Also CC detected in platelets. CC -!- PTM: A proteolytic cleavage generates a new N-terminus that CC functions as a tethered ligand. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF080214; AAC28860.1; -; mRNA. DR EMBL; AF055917; AAC25699.1; -; mRNA. DR EMBL; AY431102; AAR08487.1; -; mRNA. DR EMBL; AF384819; AAK61908.1; -; Genomic_DNA. DR EMBL; BC074782; AAH74782.2; -; mRNA. DR UniGene; Hs.137574; -. DR Ensembl; ENSG00000127533; Homo sapiens. DR HGNC; HGNC:3540; F2RL3. DR MIM; 602779; gene. DR Reactome; Q96RI0; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0015057; F:thrombin receptor activity; TAS. DR GO; GO:0007596; P:blood coagulation; TAS. DR GO; GO:0007200; P:G-protein signaling, coupled to IP3 second ...; TAS. DR GO; GO:0009611; P:response to wounding; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003944; Prot_act_rcpt_4. DR InterPro; IPR003912; Protea_act_rcpt. DR PANTHER; PTHR19264:SF136; Prot4_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01428; PROTEASEAR. DR PRINTS; PR01430; PROTEASEAR4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Blood coagulation; G-protein coupled receptor; Glycoprotein; Membrane; KW Polymorphism; Receptor; Signal; Transducer; Transmembrane. FT SIGNAL 1 17 Potential. FT PROPEP 18 47 Removed for receptor activation (By FT similarity). FT /FTId=PRO_0000012762. FT CHAIN 48 385 Proteinase-activated receptor 4. FT /FTId=PRO_0000012763. FT TOPO_DOM 48 82 Extracellular (Potential). FT TRANSMEM 83 103 1 (Potential). FT TOPO_DOM 104 108 Cytoplasmic (Potential). FT TRANSMEM 109 129 2 (Potential). FT TOPO_DOM 130 151 Extracellular (Potential). FT TRANSMEM 152 172 3 (Potential). FT TOPO_DOM 173 192 Cytoplasmic (Potential). FT TRANSMEM 193 213 4 (Potential). FT TOPO_DOM 214 247 Extracellular (Potential). FT TRANSMEM 248 268 5 (Potential). FT TOPO_DOM 269 283 Cytoplasmic (Potential). FT TRANSMEM 284 304 6 (Potential). FT TOPO_DOM 305 319 Extracellular (Potential). FT TRANSMEM 320 343 7 (Potential). FT TOPO_DOM 344 385 Cytoplasmic (Potential). FT COMPBIAS 301 305 Poly-Leu. FT SITE 47 48 Cleavage (by thrombin or trypsin) (By FT similarity). FT CARBOHYD 56 56 N-linked (GlcNAc...) (Potential). FT DISULFID 149 228 By similarity. FT VARIANT 296 296 F -> V (in dbSNP:2227346). FT /FTId=VAR_012852. FT VARIANT 310 310 P -> L (in dbSNP:2227376). FT /FTId=VAR_012853. FT MUTAGEN 47 47 R->A: No proteolytic cleavage (by FT thrombin or trypsin). FT MUTAGEN 68 68 R->A: No effect on receptor activation. FT CONFLICT 120 120 T -> A (in Ref. 5 and 6). SQ SEQUENCE 385 AA; 41163 MW; FACA62B40D5756AE CRC64; MWGRLLLWPL VLGFSLSGGT QTPSVYDESG STGGGDDSTP SILPAPRGYP GQVCANDSDT LELPDSSRAL LLGWVPTRLV PALYGLVLVV GLPANGLALW VLATQAPRLP STMLLMNLAT ADLLLALALP PRIAYHLRGQ RWPFGEAACR LATAALYGHM YGSVLLLAAV SLDRYLALVH PLRARALRGR RLALGLCMAA WLMAAALALP LTLQRQTFRL ARSDRVLCHD ALPLDAQASH WQPAFTCLAL LGCFLPLLAM LLCYGATLHT LAASGRRYGH ALRLTAVVLA SAVAFFVPSN LLLLLHYSDP SPSAWGNLYG AYVPSLALST LNSCVDPFIY YYVSAEFRDK VRAGLFQRSP GDTVASKASA EGGSRGMGTH SSLLQ // ID GALR3_MOUSE STANDARD; PRT; 370 AA. AC O88853; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 18-APR-2006, entry version 42. DE Galanin receptor type 3 (GAL3-R) (GALR3). GN Name=Galr3; Synonyms=Galnr3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; RA Kolakowski L.F. Jr., O'Neill G.P., Howard A.D., Broussard S.R., RA Sullivan K.A., Feighner S.D., Sawzdargo M., Nguyen T., Kargman S., RA Shiao L.-L., Hreniuk D.L., Tan C.P., Evans J., Abramovitz M., RA Chateauneuf A., Coulombe N., Ng G., Johnson M.P., Tharian A., RA Khoshbouei H., George S.R., Smith R.G., O'Dowd B.F.; RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for the hormone galanin. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF042783; AAC36588.1; -; Genomic_DNA. DR UniGene; Mm.377083; -. DR Ensembl; ENSMUSG00000047429; Mus musculus. DR MGI; MGI:1329003; Galr3. DR InterPro; IPR000405; Galanin_rcpt. DR InterPro; IPR003908; Galnin_3_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01420; GALANIN3R. DR PRINTS; PR00663; GALANINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 370 Galanin receptor type 3. FT /FTId=PRO_0000069470. FT TOPO_DOM 1 20 Extracellular (Potential). FT TRANSMEM 21 41 1 (Potential). FT TOPO_DOM 42 57 Cytoplasmic (Potential). FT TRANSMEM 58 78 2 (Potential). FT TOPO_DOM 79 96 Extracellular (Potential). FT TRANSMEM 97 118 3 (Potential). FT TOPO_DOM 119 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT TOPO_DOM 160 184 Extracellular (Potential). FT TRANSMEM 185 205 5 (Potential). FT TOPO_DOM 206 236 Cytoplasmic (Potential). FT TRANSMEM 237 257 6 (Potential). FT TOPO_DOM 258 259 Extracellular (Potential). FT TRANSMEM 260 280 7 (Potential). FT TOPO_DOM 281 370 Cytoplasmic (Potential). FT COMPBIAS 218 225 Poly-Ala. FT COMPBIAS 313 318 Poly-His. FT LIPID 308 308 S-palmitoyl cysteine (By similarity). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT DISULFID 95 172 By similarity. SQ SEQUENCE 370 AA; 40390 MW; D387A2FCB6D28B18 CRC64; MADIQNISLD SPGSVGAVAV PVVFALIFLL GMVGNGLVLA VLLQPGPSAW QEPGSTTDLF ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVTVV SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA RFRRLWPCGH RRHRHHHHRL HRALRRVQPA SSGPAGYPGD ARPRGWSMEP RGDALRGGET RLTLSARGPQ // ID KISSR_MOUSE STANDARD; PRT; 396 AA. AC Q91V45; Q8K3P2; DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 02-MAY-2006, entry version 33. DE KiSS-1 receptor (KiSS-1R) (Kisspeptins receptor) (Metastin receptor) DE (G-protein coupled receptor 54) (mOT7T175). GN Name=Kiss1r; Synonyms=Gpr54, Ot7t175; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX MEDLINE=21308444; PubMed=11414709; DOI=10.1006/bbrc.2001.5098; RA Clements M.K., McDonald T.P., Wang R., Xie G., O'Dowd B.F., RA George S.R., Austin C.P., Liu Q.; RT "FMRFamide-related neuropeptides are agonists of the orphan G-protein- RT coupled receptor GPR54."; RL Biochem. Biophys. Res. Commun. 284:1189-1193(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND TISSUE SPECIFICITY. RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=22246258; PubMed=12359743; RA Stafford L.J., Xia C., Ma W., Cai Y., Liu M.; RT "Identification and characterization of mouse metastasis-suppressor RT KiSS1 and its G-protein-coupled receptor."; RL Cancer Res. 62:5399-5404(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Spinal cord; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP REVIEW. RX PubMed=15519892; DOI=10.1016/j.tem.2004.09.008; RA Colledge W.H.; RT "GPR54 and puberty."; RL Trends Endocrinol. Metab. 15:448-453(2004). RN [6] RP INVOLVEMENT IN SEXUAL DEVELOPMENT. RX PubMed=14652023; DOI=10.1016/j.bbrc.2003.11.066; RA Funes S., Hedrick J.A., Vassileva G., Markowitz L., Abbondanzo S., RA Golovko A., Yang S., Monsma F.J., Gustafson E.L.; RT "The KiSS-1 receptor GPR54 is essential for the development of the RT murine reproductive system."; RL Biochem. Biophys. Res. Commun. 312:1357-1363(2003). RN [7] RP INVOLVEMENT IN SEXUAL DEVELOPMENT. RX MEDLINE=22935708; PubMed=14573733; DOI=10.1056/NEJMoa035322; RA Seminara S.B., Messager S., Chatzidaki E.E., Thresher R.R., RA Acierno J.S. Jr., Shagoury J.K., Bo-Abbas Y., Kuohung W., RA Schwinof K.M., Hendrick A.G., Zahn D., Dixon J., Kaiser U.B., RA Slaugenhaupt S.A., Gusella J.F., O'Rahilly S., Carlton M.B.L., RA Crowley W.F. Jr., Aparicio S.A.J.R., Colledge W.H.; RT "The GPR54 gene as a regulator of puberty."; RL N. Engl. J. Med. 349:1614-1627(2003). RN [8] RP TISSUE SPECIFICITY, AND DIRECT STIMULATION OF GONADOTROPIN-RELEASING RP HORMONE RELEASE. RX PubMed=15665093; DOI=10.1073/pnas.0409330102; RA Messager S., Chatzidaki E.E., Ma D., Hendrick A.G., Zahn D., Dixon J., RA Thresher R.R., Malinge I., Lomet D., Carlton M.B., Colledge W.H., RA Caraty A., Aparicio S.A.J.R.; RT "Kisspeptin directly stimulates gonadotropin-releasing hormone release RT via G protein-coupled receptor 54."; RL Proc. Natl. Acad. Sci. U.S.A. 102:1761-1766(2005). CC -!- FUNCTION: Receptor for metastin (kisspeptin-52 or kp-52), a C- CC terminally amidated peptide of KiSS1. KiSS1 is a metastasis CC suppressor protein. Activation of the receptor inhibits cell CC proliferation and cell migration, key characteristics of tumor CC metastasis. The receptor is essential for normal gonadotropin- CC released hormone physiology and for puberty. The hypothalamic CC KiSS1/KISS1R system is a pivotal factor in central regulation of CC the gonadotropic axis at puberty and in adulthood. Analysis of the CC transduction pathways activated by the receptor identifies CC coupling to phospholipase C and intracellular calcium release CC through pertussis toxin-insensitive G(q) proteins. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Highest level in the heart and 15- and 17-day CC embryos. Low level in other tissues. Colocalized with CC gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF343726; AAK83236.1; -; mRNA. DR EMBL; AY044228; AAK95814.1; -; mRNA. DR EMBL; AK039628; BAC30404.1; -; mRNA. DR EMBL; BC016531; AAH16531.1; -; mRNA. DR UniGene; Mm.191035; -. DR Ensembl; ENSMUSG00000035773; Mus musculus. DR MGI; MGI:2148793; Gpr54. DR GO; GO:0009986; C:cell surface; IDA. DR GO; GO:0008528; F:peptide receptor activity, G-protein coupled; IDA. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0030336; P:negative regulation of cell migration; IPI. DR GO; GO:0008285; P:negative regulation of cell proliferation; IPI. DR GO; GO:0007165; P:signal transduction; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008103; KiSS_1_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01728; KISS1RECEPTR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 396 KiSS-1 receptor. FT /FTId=PRO_0000069696. FT TOPO_DOM 1 43 Extracellular (Potential). FT TRANSMEM 44 66 1 (Potential). FT TOPO_DOM 67 78 Cytoplasmic (Potential). FT TRANSMEM 79 101 2 (Potential). FT TOPO_DOM 102 116 Extracellular (Potential). FT TRANSMEM 117 138 3 (Potential). FT TOPO_DOM 139 157 Cytoplasmic (Potential). FT TRANSMEM 158 180 4 (Potential). FT TOPO_DOM 181 203 Extracellular (Potential). FT TRANSMEM 204 224 5 (Potential). FT TOPO_DOM 225 260 Cytoplasmic (Potential). FT TRANSMEM 261 283 6 (Potential). FT TOPO_DOM 284 305 Extracellular (Potential). FT TRANSMEM 306 330 7 (Potential). FT TOPO_DOM 331 396 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT DISULFID 115 191 By similarity. FT CONFLICT 82 82 Missing (in Ref. 2). SQ SEQUENCE 396 AA; 43061 MW; B5354E739A1F185B CRC64; MATEATLAPN VTWWAPSNAS GCPGCGVNAS DDPGSAPRPL DAWLVPLFFA TLMLLGLVGN SLVIYVICRH KHMQTVTNFY IANLAATDVT FLLCCVPFTA LLYPLPAWVL GDFMCKFVNY IQQVSVQATC ATLTAMSVDR WYVTVFPLRA LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL HRLSPGPRTY CSEAFPSRAL ERAFALYNLL ALYLLPLLAT CACYGAMLRH LGRAAVRPAP TDGALQGQLL AQRAGAVRTK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP SGAWHPRSYA AYAVKIWAHC MSYSNSALNP LLYAFLGSHF RQAFCRVCPC CRQRQRRPHT SAHSDRAATH TVPHSRAAHP VRIRSPEPGN PVVRSPCAQS ERTASL // ID MCHR1_HUMAN STANDARD; PRT; 422 AA. AC Q99705; Q5R3J1; Q96S47; Q9BV08; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 15-AUG-2003, sequence version 2. DT 18-APR-2006, entry version 53. DE Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCHR-1) DE (MCH-R1) (MCH1R) (MCH-1R) (MCHR) (G-protein coupled receptor 24) DE (Somatostatin receptor-like protein) (SLC-1). GN Name=MCHR1; Synonyms=GPR24, SLC1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=99373129; PubMed=10441476; DOI=10.1006/bbrc.1999.1104; RA Shimomura Y., Mori M., Sugo T., Ishibashi Y., Abe M., Kurokawa T., RA Onda H., Nishimura O., Sumino Y., Fujino M.; RT "Isolation and identification of melanin-concentrating hormone as the RT endogenous ligand of the SLC-1 receptor."; RL Biochem. Biophys. Res. Commun. 261:622-626(1999). RN [2] RP NUCLEOTIDE SEQUENCE, AND VARIANT ASP-32. RA Wermter A.-K., Reichwald K., Platzer M., Preibisch G., Geller F., RA Schaefer H., Remschmidt H., Platzer C., Siefried W., RA Goldschmidt H.-P., Huse K., Gudermann T., Hinney A., Hebebrand J.; RT "Contribution of a nonsynonymous cSNP in the MCHR gene to human RT obesity."; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32. RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84; RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., RA Beare D.M., Dunham I.; RT "A genome annotation-driven approach to cloning the human ORFeome."; RL Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32. RC TISSUE=Brain; RA King M.M., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=20057165; PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., RA Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., RA Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., RA Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J., RA Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., RA Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., RA Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., RA Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., RA Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., RA Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., RA Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., RA Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., RA Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., RA Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., RA Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., RA Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., RA Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., RA Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., RA Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., RA Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., RA Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., RA Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., RA Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., RA Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., RA Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., RA Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., RA Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., RA Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., RA Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., RA Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., RA Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., RA Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., RA Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., RA O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., RA Khan A.S., Lane L., Tilahun Y., Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-32. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-422. RX MEDLINE=97131607; PubMed=8977118; DOI=10.1016/S0014-5793(96)01160-X; RA Kolakowski L.F. Jr., Jung B.P., Nguyen T., Johnson M.P., Lynch K.R., RA Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.; RT "Characterization of a human gene related to genes encoding RT somatostatin receptors."; RL FEBS Lett. 398:253-258(1996). RN [9] RP FUNCTION. RX MEDLINE=99347735; PubMed=10421367; DOI=10.1038/22313; RA Chambers J., Ames R.S., Bergsma D., Muir A., Fitzgerald L.R., RA Hervieu G., Dytko G.M., Foley J.J., Martin J., Liu W.S., Park J., RA Ellis C., Ganguly S., Konchar S., Cluderay J., Leslie R., Wilson S., RA Sarau H.M.; RT "Melanin-concentrating hormone is the cognate ligand for the orphan G- RT protein-coupled receptor SLC-1."; RL Nature 400:261-265(1999). CC -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to CC both G proteins that inhibit adenylyl cyclase and G proteins that CC activate phosphoinositide hydrolysis. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Highest level in brain, particularly in the CC frontal cortex and hypothalamus, lower levels in the liver and CC heart. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: It is uncertain whether Met-1, Met-6 or Met-70 is the CC initiator. CC -!- CAUTION: Ref.8 sequence differs from that shown due to erroneous CC gene model prediction. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB063174; BAB60890.1; -; mRNA. DR EMBL; AF490537; AAO14670.1; -; mRNA. DR EMBL; BT006725; AAP35371.1; -; mRNA. DR EMBL; CR456497; CAG30383.1; -; mRNA. DR EMBL; AY562945; AAS72373.1; -; mRNA. DR EMBL; Z86090; CAI17933.1; -; Genomic_DNA. DR EMBL; BC001736; AAH01736.1; -; mRNA. DR EMBL; BC021146; AAH21146.1; -; mRNA. DR EMBL; U71092; AAC14587.1; ALT_SEQ; Genomic_DNA. DR PIR; JC7080; JC7080. DR UniGene; Hs.248122; -. DR Ensembl; ENSG00000128285; Homo sapiens. DR HGNC; HGNC:4479; MCHR1. DR MIM; 601751; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0008188; F:neuropeptide receptor activity; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS. DR GO; GO:0007631; P:feeding behavior; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0007193; P:G-protein signaling, adenylate cyclase inhi...; TAS. DR GO; GO:0006091; P:generation of precursor metabolites and energy; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR004047; MCH1_rcpt. DR InterPro; IPR008361; MCH_rcpt. DR PANTHER; PTHR19264:SF162; MCH1_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01507; MCH1RECEPTOR. DR PRINTS; PR01783; MCHRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 422 Melanin-concentrating hormone receptor 1. FT /FTId=PRO_0000069734. FT TOPO_DOM 1 113 Extracellular (Potential). FT TRANSMEM 114 136 1 (Potential). FT TOPO_DOM 137 148 Cytoplasmic (Potential). FT TRANSMEM 149 171 2 (Potential). FT TOPO_DOM 172 185 Extracellular (Potential). FT TRANSMEM 186 208 3 (Potential). FT TOPO_DOM 209 227 Cytoplasmic (Potential). FT TRANSMEM 228 250 4 (Potential). FT TOPO_DOM 251 278 Extracellular (Potential). FT TRANSMEM 279 301 5 (Potential). FT TOPO_DOM 302 321 Cytoplasmic (Potential). FT TRANSMEM 322 344 6 (Potential). FT TOPO_DOM 345 358 Extracellular (Potential). FT TRANSMEM 359 381 7 (Potential). FT TOPO_DOM 382 422 Cytoplasmic (Potential). FT CARBOHYD 82 82 N-linked (GlcNAc...) (Potential). FT CARBOHYD 85 85 N-linked (GlcNAc...) (Potential). FT CARBOHYD 92 92 N-linked (GlcNAc...) (Potential). FT VARIANT 32 32 N -> D. FT /FTId=VAR_016221. SQ SEQUENCE 422 AA; 45963 MW; 3986919A18183818 CRC64; MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP AWVEGSSARL WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP RTGSISYINI IMPSVFGTIC LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF IINLSVVDLL FLLGMPFMIH QLMGNGVWHF GETMCTLITA MDANSQFTST YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS FISITPVWLY ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS ISRPTLTFVY LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ GQLRAVSNAQ TADEERTESK GT // ID SSR1_HUMAN STANDARD; PRT; 391 AA. AC P30872; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 18-APR-2006, entry version 53. DE Somatostatin receptor type 1 (SS1R) (SRIF-2). GN Name=SSTR1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92108031; PubMed=1346068; RA Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.; RT "Cloning and functional characterization of a family of human and RT mouse somatostatin receptors expressed in brain, gastrointestinal RT tract, and kidney."; RL Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP INTERACTION WITH SKB1. RX MEDLINE=20200451; PubMed=10734105; DOI=10.1074/jbc.275.13.9557; RA Schwaerzler A., Kreienkamp H.-J., Richter D.; RT "Interaction of the somatostatin receptor subtype 1 with the human RT homolog of the Shk1 kinase-binding protein from yeast."; RL J. Biol. Chem. 275:9557-9562(2000). CC -!- FUNCTION: Receptor for somatostatin with higher affinity for CC somatostatin-14 than -28. This receptor is coupled via pertussis CC toxin sensitive G proteins to inhibition of adenylyl cyclase. In CC addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) CC exchanger via pertussis toxin insensitive G proteins. CC -!- SUBUNIT: Interacts with SKB1. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Fetal kidney, fetal liver, and adult pancreas, CC brain, lung, jejunum and stomach. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M81829; AAA58247.1; -; Genomic_DNA. DR EMBL; AY322536; AAP84349.1; -; Genomic_DNA. DR EMBL; BC035618; AAH35618.1; -; mRNA. DR PIR; A41795; A41795. DR UniGene; Hs.248160; -. DR Ensembl; ENSG00000139874; Homo sapiens. DR HGNC; HGNC:11330; SSTR1. DR MIM; 182451; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004994; F:somatostatin receptor activity; IDA. DR GO; GO:0007166; P:cell surface receptor linked signal transdu...; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0007586; P:digestion; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0008285; P:negative regulation of cell proliferation; TAS. DR GO; GO:0007584; P:response to nutrient; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000586; Somatstn_rcpt. DR InterPro; IPR001116; Somatstn_rcpt_1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00587; SOMATOSTTN1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 391 Somatostatin receptor type 1. FT /FTId=PRO_0000070116. FT TOPO_DOM 1 56 Extracellular (Potential). FT TRANSMEM 57 84 1 (Potential). FT TOPO_DOM 85 94 Cytoplasmic (Potential). FT TRANSMEM 95 120 2 (Potential). FT TOPO_DOM 121 131 Extracellular (Potential). FT TRANSMEM 132 153 3 (Potential). FT TOPO_DOM 154 175 Cytoplasmic (Potential). FT TRANSMEM 176 196 4 (Potential). FT TOPO_DOM 197 219 Extracellular (Potential). FT TRANSMEM 220 244 5 (Potential). FT TOPO_DOM 245 270 Cytoplasmic (Potential). FT TRANSMEM 271 296 6 (Potential). FT TOPO_DOM 297 303 Extracellular (Potential). FT TRANSMEM 304 327 7 (Potential). FT TOPO_DOM 328 391 Cytoplasmic (Potential). FT LIPID 339 339 S-palmitoyl cysteine (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 44 44 N-linked (GlcNAc...) (Potential). FT CARBOHYD 48 48 N-linked (GlcNAc...) (Potential). FT DISULFID 130 208 By similarity. SQ SEQUENCE 391 AA; 42686 MW; 85C99AFFF339A43D CRC64; MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCTSRITT L // ID SSR3_MOUSE STANDARD; PRT; 428 AA. AC P30935; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 18-APR-2006, entry version 43. DE Somatostatin receptor type 3 (SS3R) (SSR-28). GN Name=Sstr3; Synonyms=Smstr3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=93015924; PubMed=1328199; RA Yasuda K., Rens-Domiano S., Breder C.D., Law S.F., Saper C.B., RA Reisine T., Bell G.I.; RT "Cloning of a novel somatostatin receptor, SSTR3, coupled to RT adenylylcyclase."; RL J. Biol. Chem. 267:20422-20428(1992). CC -!- FUNCTION: Receptor for somatostatins-14 and -28. This receptor is CC coupled via pertussis toxin sensitive G proteins to inhibition of CC adenylyl cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC Internalized into endoplasmic vesicles upon somatostatin- CC stimulation (By similarity). CC -!- PTM: Phosphorylated. Phosphorylation increases upon somatostatin CC binding (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M91000; AAA40144.1; -; Genomic_DNA. DR PIR; A44021; A44021. DR UniGene; Mm.211411; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSMUSG00000044933; Mus musculus. DR MGI; MGI:98329; Sstr3. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000586; Somatstn_rcpt. DR InterPro; IPR001856; Somatstn_rcpt_3. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00589; SOMATOSTTN3R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphorylation; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 428 Somatostatin receptor type 3. FT /FTId=PRO_0000070125. FT TOPO_DOM 1 45 Extracellular (Potential). FT TRANSMEM 46 71 1 (Potential). FT TOPO_DOM 72 81 Cytoplasmic (Potential). FT TRANSMEM 82 103 2 (Potential). FT TOPO_DOM 104 118 Extracellular (Potential). FT TRANSMEM 119 140 3 (Potential). FT TOPO_DOM 141 162 Cytoplasmic (Potential). FT TRANSMEM 163 182 4 (Potential). FT TOPO_DOM 183 206 Extracellular (Potential). FT TRANSMEM 207 232 5 (Potential). FT TOPO_DOM 233 266 Cytoplasmic (Potential). FT TRANSMEM 267 288 6 (Potential). FT TOPO_DOM 289 302 Extracellular (Potential). FT TRANSMEM 303 325 7 (Potential). FT TOPO_DOM 326 428 Cytoplasmic (Potential). FT COMPBIAS 358 373 Poly-Glu. FT MOD_RES 341 341 Phosphoserine (By similarity). FT MOD_RES 346 346 Phosphoserine (By similarity). FT MOD_RES 351 351 Phosphoserine (By similarity). FT MOD_RES 357 357 Phosphothreonine (By similarity). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT DISULFID 117 192 By similarity. SQ SEQUENCE 428 AA; 47391 MW; D006E4B7BE501FAA CRC64; MATVTYPSSE PMTLDPGNTS STWPLDTTLG NTSAGASLTG LAVSGILISL VYLVVCVVGL LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF LAAQNALSYW PFGSLMCRLV MAVDGINQFT SIFCLTVMSV DRYLAVVHPT RSARWRTAPV ARTVSRAVWV ASAVVVLPVV VFSGVPRGMS TCHMQWPEPA AAWRTAFIIY MAALGFFGPL LVICLCYLLI VVKVRSTTRR VRAPSCQWVQ APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRIRSQEPG SGPPEKTEEE EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QAGTSGQQPR PCTGTAKEQQ LLPQEATAGD KASTLSHL // ID SSR2_HUMAN STANDARD; PRT; 369 AA. AC P30874; Q96GE0; Q96TF2; Q9BWH1; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 18-APR-2006, entry version 56. DE Somatostatin receptor type 2 (SS2R) (SRIF-1). GN Name=SSTR2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORM A). RX MEDLINE=92108031; PubMed=1346068; RA Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.; RT "Cloning and functional characterization of a family of human and RT mouse somatostatin receptors expressed in brain, gastrointestinal RT tract, and kidney."; RL Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992). RN [2] RP NUCLEOTIDE SEQUENCE (ISOFORMS A AND B). RX MEDLINE=20084417; PubMed=10619399; DOI=10.1016/S0303-7207(99)00161-6; RA Petersenn S., Rasch A.C., Presch S., Beil F.U., Schulte H.M.; RT "Genomic structure and transcriptional regulation of the human RT somatostatin receptor type 2."; RL Mol. Cell. Endocrinol. 157:75-85(1999). RN [3] RP NUCLEOTIDE SEQUENCE (ISOFORM A). RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "Isolation of complete coding sequence for somatostatin receptor 2 RT (SSTR2)."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE (ISOFORM A). RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). RC TISSUE=Eye; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP ALTERNATIVE SPLICING. RX MEDLINE=93236586; PubMed=8386508; RA Patel Y.C., Greenwood M., Kent G., Panetta R., Srikant C.B.; RT "Multiple gene transcripts of the somatostatin receptor SSTR2: tissue RT selective distribution and cAMP regulation."; RL Biochem. Biophys. Res. Commun. 192:288-294(1993). RN [8] RP INTERACTION WITH SHANK1. RX MEDLINE=20020275; PubMed=10551867; DOI=10.1074/jbc.274.46.32997; RA Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.; RT "Somatostatin receptor interacting protein defines a novel family of RT multidomain proteins present in human and rodent brain."; RL J. Biol. Chem. 274:32997-33001(1999). CC -!- FUNCTION: Receptor for somatostatins-14 and -28. This receptor is CC coupled via pertussis toxin sensitive G proteins to inhibition of CC adenylyl cyclase. In addition it stimulates phosphotyrosine CC phosphatase and PLC via pertussis toxin insensitive as well as CC sensitive G proteins. In RIN-5F cells, this receptor inhibits CC calcium entry by suppressing voltage dependent calcium-channels. CC -!- SUBUNIT: The C-terminus interacts with SHANK1 PDZ domain. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=A; Synonyms=SSTR2A; CC IsoId=P30874-1; Sequence=Displayed; CC Name=B; Synonyms=SSTR2B; CC IsoId=P30874-2; Sequence=VSP_001922; CC -!- TISSUE SPECIFICITY: Cerebrum and kidney. In lesser amounts in CC jejunum, colon and liver. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M81830; AAA58248.1; -; Genomic_DNA. DR EMBL; AF184174; AAF42809.1; -; Genomic_DNA. DR EMBL; AF184174; AAF42810.1; -; Genomic_DNA. DR EMBL; AB065911; BAC06126.1; -; Genomic_DNA. DR EMBL; AY236542; AAO92064.1; -; Genomic_DNA. DR EMBL; BT019926; AAV38729.1; -; mRNA. DR EMBL; BC000256; AAH00256.1; -; mRNA. DR EMBL; BC009522; AAH09522.1; -; mRNA. DR EMBL; BC019610; AAH19610.1; -; mRNA. DR PIR; B41795; B41795. DR UniGene; Hs.514451; -. DR HSSP; P02699; 1BOJ. DR Ensembl; ENSG00000180616; Homo sapiens. DR H-InvDB; HIX0014133; -. DR HGNC; HGNC:11331; SSTR2. DR MIM; 182452; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0030165; F:PDZ domain binding; IPI. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0004994; F:somatostatin receptor activity; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0007586; P:digestion; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0008285; P:negative regulation of cell proliferation; TAS. DR GO; GO:0007584; P:response to nutrient; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000586; Somatstn_rcpt. DR InterPro; IPR002074; Somatstn_rcpt_2. DR PANTHER; PTHR19264:SF169; Smtatn_receptor2; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00246; SOMATOSTATNR. DR PRINTS; PR00588; SOMATOSTTN2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; G-protein coupled receptor; Glycoprotein; KW Lipoprotein; Membrane; Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 369 Somatostatin receptor type 2. FT /FTId=PRO_0000070120. FT TOPO_DOM 1 43 Extracellular (Potential). FT TRANSMEM 44 67 1 (Potential). FT TOPO_DOM 68 78 Cytoplasmic (Potential). FT TRANSMEM 79 103 2 (Potential). FT TOPO_DOM 104 118 Extracellular (Potential). FT TRANSMEM 119 138 3 (Potential). FT TOPO_DOM 139 161 Cytoplasmic (Potential). FT TRANSMEM 162 181 4 (Potential). FT TOPO_DOM 182 207 Extracellular (Potential). FT TRANSMEM 208 229 5 (Potential). FT TOPO_DOM 230 253 Cytoplasmic (Potential). FT TRANSMEM 254 278 6 (Potential). FT TOPO_DOM 279 288 Extracellular (Potential). FT TRANSMEM 289 303 7 (Potential). FT TOPO_DOM 304 369 Cytoplasmic (Potential). FT LIPID 328 328 S-palmitoyl cysteine (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 32 32 N-linked (GlcNAc...) (Potential). FT DISULFID 115 193 By similarity. FT VARSPLIC 332 369 VSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI -> FT VDNSKSGEEGSCLDMIFRNNKNRKK (in isoform B). FT /FTId=VSP_001922. SQ SEQUENCE 369 AA; 41333 MW; 3B5D7D8A9AC246C6 CRC64; MDMADEPLNG SHTWLSIPFD LNGSVVSTNT SNQTEPYYDL TSNAVLTFIY FVVCIIGLCG NTLVIYVILR YAKMKTITNI YILNLAIADE LFMLGLPFLA MQVALVHWPF GKAICRVVMT VDGINQFTSI FCLTVMSIDR YLAVVHPIKS AKWRRPRTAK MITMAVWGVS LLVILPIMIY AGLRSNQWGR SSCTINWPGE SGAWYTGFII YTFILGFLVP LTIICLCYLF IIIKVKSSGI RVGSSKRKKS EKKVTRMVSI VVAVFIFCWL PFYIFNVSSV SMAISPTPAL KGMFDFVVVL TYANSCANPI LYAFLSDNFK KSFQNVLCLV KVSGTDDGER SDSKQDKSRL NETTETQRTL LNGDLQTSI // ID OPRM_BOVIN STANDARD; PRT; 401 AA. AC P79350; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1999, sequence version 2. DT 04-APR-2006, entry version 41. DE Mu-type opioid receptor (MOR-1). GN Name=OPRM1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Corpus striatum; RX MEDLINE=20050861; PubMed=10581406; DOI=10.1016/S0169-328X(99)00249-1; RA Onoprishvili I., Andria M.L., Vilim F.S., Hiller J.M., Simon E.J.; RT "The bovine mu-opioid receptor: cloning of cDNA and pharmacological RT characterization of the receptor expressed in mammalian cells."; RL Brain Res. Mol. Brain Res. 73:129-137(1999). CC -!- FUNCTION: Inhibits neurotransmitter release by reducing calcium CC ion currents and increasing potassium ion conductance. Receptor CC for beta-endorphin. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U89677; AAB49477.2; -; mRNA. DR UniGene; Bt.242; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000105; Mu_opioid_rcpt. DR InterPro; IPR001418; Opioid_rcpt. DR PANTHER; PTHR19264:SF166; Opioid_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00537; MUOPIOIDR. DR PRINTS; PR00384; OPIOIDR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 401 Mu-type opioid receptor. FT /FTId=PRO_0000069970. FT TOPO_DOM 1 67 Extracellular (Potential). FT TRANSMEM 68 97 1 (Potential). FT TOPO_DOM 98 106 Cytoplasmic (Potential). FT TRANSMEM 107 124 2 (Potential). FT TOPO_DOM 125 146 Extracellular (Potential). FT TRANSMEM 147 166 3 (Potential). FT TOPO_DOM 167 196 Cytoplasmic (Potential). FT TRANSMEM 197 212 4 (Potential). FT TOPO_DOM 213 237 Extracellular (Potential). FT TRANSMEM 238 260 5 (Potential). FT TOPO_DOM 261 283 Cytoplasmic (Potential). FT TRANSMEM 284 306 6 (Potential). FT TOPO_DOM 307 314 Extracellular (Potential). FT TRANSMEM 315 331 7 (Potential). FT TOPO_DOM 332 401 Cytoplasmic (Potential). FT LIPID 354 354 S-palmitoyl cysteine (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential). FT CARBOHYD 41 41 N-linked (GlcNAc...) (Potential). FT CARBOHYD 49 49 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 401 AA; 45028 MW; 6DA8592F29299C6E CRC64; MDSGAVPTNA SNCTDPFTHP SSCSPAPSPS SWVNFSHLEG NLSDPCGPNR TELGGSDRLC PSAGSPSMIT AIIIMALYSI VCVVGLFGNF LVMYVIVRYT KMKTATNIYI FNLALADALA TSTLPFQSVN YLMGTWPFGT ILCKIVISID YYNMFTSIFT LCTMSVDRYI AVCHPVKALD LRTPRNAKII NICNWILSSA IGLPVMFMAT TKYRQGSIDC TLTFSHPTWY WENLLKICVF IFAFIMPILI ITVCYGLMIL RLKSVRMLSG SKEKDRNLRR ITRMVLVVVA VFIVCWTPIH IYVIIKALIT IPETTFQTVS WHFCIALGYT NSCLNPVLYA FLDENFKRCF REFCIPTSST IEQQNSTRIR QNTRDHPSTA NTVDRTNHQL ENLEAETTPL P // ID OPRX_MOUSE STANDARD; PRT; 367 AA. AC P35377; Q60645; Q8VI74; Q9QUT5; Q9Z2M8; Q9Z2M9; Q9Z2N0; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 1. DT 18-APR-2006, entry version 58. DE Nociceptin receptor (Orphanin FQ receptor) (Kappa-type 3 opioid DE receptor) (KOR-3) (ORGC) (K3 opiate receptor). GN Name=Oprl1; Synonyms=Oor, Oprl; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORM KOR3). RC STRAIN=C57BL/6N; TISSUE=Brain; RA Yasuda K., Jones E., Reisine T., Bell G.I.; RL Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE (ISOFORM KOR3). RX MEDLINE=95100967; PubMed=7802669; RA Nishi M., Takeshima H., Mori M., Nakagawara K., Takeuchi T.; RT "Structure and chromosomal mapping of genes for the mouse kappa-opioid RT receptor and an opioid receptor homologue (MOR-C)."; RL Biochem. Biophys. Res. Commun. 205:1353-1357(1994). RN [3] RP NUCLEOTIDE SEQUENCE (ISOFORM KOR3). RC TISSUE=Brain; RX MEDLINE=96387345; PubMed=8794880; RA Matthes H.W.D., Seward E.P., Kieffer B., North R.A.; RT "Functional selectivity of orphanin FQ for its receptor coexpressed RT with potassium channel subunits in Xenopus laevis oocytes."; RL Mol. Pharmacol. 50:447-450(1996). RN [4] RP NUCLEOTIDE SEQUENCE (ISOFORM KOR3). RA Pan Y.-X., Xu J., Pasternak G.W.; RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE (ISOFORM KOR3). RX MEDLINE=95327076; PubMed=7603458; RA Pan Y.-X., Cheng J., Xu J., Rossi G., Jacobson E., Ryan-Moro J., RA Brooks A.I., Dean G.E., Standifer K.M., Pasternak G.W.; RT "Cloning and functional characterization through antisense mapping of RT a kappa 3-related opioid receptor."; RL Mol. Pharmacol. 47:1180-1188(1995). RN [6] RP NUCLEOTIDE SEQUENCE (ISOFORMS KOR3A; KOR3B; KOR3C; KOR3D AND KOR3E), RP AND TISSUE SPECIFICITY. RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=98427291; PubMed=9755860; DOI=10.1016/S0014-5793(98)01039-4; RA Pan Y.-X., Xu J., Wan B.-L., Zuckerman A., Pasternak G.W.; RT "Identification and differential regional expression of KOR-3/ORL-1 RT gene splice variants in mouse brain."; RL FEBS Lett. 435:65-68(1998). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM KOR3). RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [8] RP NUCLEOTIDE SEQUENCE OF 1-357 (ISOFORM KOR3). RC STRAIN=BALB/c; TISSUE=Spleen; RX MEDLINE=95318231; PubMed=7797625; DOI=10.1016/0165-5728(95)00030-6; RA Halford W.P., Gebhardt B.M., Carr D.J.J.; RT "Functional role and sequence analysis of a lymphocyte orphan opioid RT receptor."; RL J. Neuroimmunol. 59:91-101(1995). CC -!- FUNCTION: Receptor for the neuropeptide nocipeptin/orphanin FQ. CC Has a potential role in modulating a number of brain functions, CC including instinctive behaviors and emotions. The activity of this CC receptor is mediated by G proteins which inhibits adenylyl CC cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=6; CC Name=KOR3; CC IsoId=P35377-1; Sequence=Displayed; CC Name=KOR3A; CC IsoId=P35377-2; Sequence=VSP_001899, VSP_001900; CC Name=KOR3B; CC IsoId=P35377-3; Sequence=VSP_001903, VSP_001904; CC Name=KOR3C; CC IsoId=P35377-4; Sequence=VSP_001901, VSP_001902; CC Name=KOR3D; CC IsoId=P35377-5; Sequence=VSP_001898; CC Name=KOR3E; CC IsoId=P35377-6; Sequence=VSP_001905, VSP_001906; CC -!- TISSUE SPECIFICITY: In the brain, isoform KOR3 and isoform KOR3C CC are most abundant in hypothalamus and periaqueductal gray. Isoform CC KOR3A is highly expressed in cortex, striatum and brainstem. CC Isoform KOR3D is highly expressed in cerebellum, hypothalamus and CC brainstem. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U04952; AAA03730.1; -; mRNA. DR EMBL; D31667; BAA06509.1; -; Genomic_DNA. DR EMBL; X91813; CAA62922.1; -; mRNA. DR EMBL; U32932; AAC52669.1; -; Genomic_DNA. DR EMBL; U32928; AAC52669.1; JOINED; Genomic_DNA. DR EMBL; U32930; AAC52669.1; JOINED; Genomic_DNA. DR EMBL; U09421; AAA81333.1; -; mRNA. DR EMBL; AF043276; AAC64507.1; -; mRNA. DR EMBL; AF043277; AAC64508.1; -; mRNA. DR EMBL; AF043278; AAC64509.1; -; mRNA. DR EMBL; AF062381; AAF21258.1; -; mRNA. DR EMBL; AF075605; AAF21781.1; -; mRNA. DR EMBL; AF126469; AAL54889.1; -; mRNA. DR EMBL; BC050885; AAH50885.1; -; mRNA. DR EMBL; U14165; AAA87899.1; -; mRNA. DR PIR; I49022; I49022. DR PIR; JC2421; JC2421. DR UniGene; Mm.285075; -. DR HSSP; P34996; 1DDD. DR Ensembl; ENSMUSG00000027584; Mus musculus. DR MGI; MGI:97440; Oprl1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001418; Opioid_rcpt. DR InterPro; IPR001420; X_opioid_rcpt. DR PANTHER; PTHR19264:SF166; Opioid_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00384; OPIOIDR. DR PRINTS; PR00547; XOPIOIDR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; G-protein coupled receptor; Glycoprotein; KW Lipoprotein; Membrane; Palmitate; Phosphorylation; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 367 Nociceptin receptor. FT /FTId=PRO_0000069981. FT TOPO_DOM 1 47 Extracellular (Potential). FT TRANSMEM 48 74 1 (Potential). FT TOPO_DOM 75 84 Cytoplasmic (Potential). FT TRANSMEM 85 106 2 (Potential). FT TOPO_DOM 107 121 Extracellular (Potential). FT TRANSMEM 122 143 3 (Potential). FT TOPO_DOM 144 162 Cytoplasmic (Potential). FT TRANSMEM 163 185 4 (Potential). FT TOPO_DOM 186 208 Extracellular (Potential). FT TRANSMEM 209 233 5 (Potential). FT TOPO_DOM 234 261 Cytoplasmic (Potential). FT TRANSMEM 262 285 6 (Potential). FT TOPO_DOM 286 297 Extracellular (Potential). FT TRANSMEM 298 319 7 (Potential). FT TOPO_DOM 320 367 Cytoplasmic (Potential). FT LIPID 331 331 S-palmitoyl cysteine (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT DISULFID 120 197 By similarity. FT VARSPLIC 71 75 Missing (in isoform KOR3D). FT /FTId=VSP_001898. FT VARSPLIC 75 99 RHTKMKTATNIYIFNLALADTLVLL -> SWEGIEGNWRQQ FT AHQDEDCYQHLHI (in isoform KOR3A). FT /FTId=VSP_001899. FT VARSPLIC 76 111 HTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLG -> Q FT CPENPLRGVLRETEERRQHLSLLIPSTNSHSGTPR (in FT isoform KOR3B). FT /FTId=VSP_001903. FT VARSPLIC 76 95 HTKMKTATNIYIFNLALADT -> QHCALGRSLMNFTGSAL FT KTL (in isoform KOR3C). FT /FTId=VSP_001901. FT VARSPLIC 96 367 Missing (in isoform KOR3C). FT /FTId=VSP_001902. FT VARSPLIC 100 367 Missing (in isoform KOR3A). FT /FTId=VSP_001900. FT VARSPLIC 112 367 Missing (in isoform KOR3B). FT /FTId=VSP_001904. FT VARSPLIC 194 213 EIECLVEIPAPQDYWGPVFA -> GQWAVLLPDQSVPHGSC FT RPL (in isoform KOR3E). FT /FTId=VSP_001905. FT VARSPLIC 214 367 Missing (in isoform KOR3E). FT /FTId=VSP_001906. FT CONFLICT 348 349 SI -> TV (in Ref. 2). SQ SEQUENCE 367 AA; 40491 MW; E498CA9FE5276026 CRC64; MESLFPAPFW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI GGLLGNCLVM YVILRHTKMK TATNIYIFNL ALADTLVLLT LPFQGTDILL GFWPFGNALC KTVIAIDYYN MFTSTFTLTA MSVDRYVAIC HPIRALDVRT SSKAQAVNVA IWALASVVGV PVAIMGSAQV EDEEIECLVE IPAPQDYWGP VFAICIFLFS FIIPVLIISV CYSLMIRRLR GVRLLSGSRE KDRNLRRITR LVLVVVAVFV GCWTPVQVFV LVQGLGVQPG SETAVAILRF CTALGYVNSC LNPILYAFLD ENFKACFRKF CCASALHREM QVSDRVRSIA KDVGLGCKTS ETVPRPA // ID NPY6R_MOUSE STANDARD; PRT; 371 AA. AC Q61212; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 02-MAY-2006, entry version 48. DE Neuropeptide Y receptor type 6 (NPY6-R) (Pancreatic polypeptide DE receptor 2) (PP2). GN Name=Npy6r; Synonyms=Npy5r, Ppyr2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129; RX MEDLINE=96279200; PubMed=8663568; DOI=10.1074/jbc.271.28.16435; RA Weinberg D.H., Sirinathsinghji D.J.S., Tan C.P., Shiao L.-L., RA Morin N., Rigby M.R., Heavens R.H., Rapoport D.R., Bayne M.L., RA Cascieri M.A., Strader C.D., Linemeyer D.L., Macneil D.J.; RT "Cloning and expression of a novel neuropeptide Y receptor."; RL J. Biol. Chem. 271:16435-16438(1996). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/Sv; RX MEDLINE=97066971; PubMed=8910373; DOI=10.1074/jbc.271.44.27776; RA Gregor P., Feng Y., Decarr L.B., Cornfield L.J., McCaleb M.L.; RT "Molecular characterization of a second mouse pancreatic polypeptide RT receptor and its inactivated human homologue."; RL J. Biol. Chem. 271:27776-27781(1996). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Ovary; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank CC order of affinity of this receptor for pancreatic polypeptides is CC NPY = PYY >= NPY (2-36) = [Leu-31, Pro-34] NPY > NPY (13-36) > PP. CC The activity of this receptor is mediated by g proteins that CC inhibits adenylate cyclase activity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Kidney and discrete regions of the CC hypothalamus including the suprachiasmatic nucleus, anterior CC hypothalamus, bed nucleus stria terminalis, and the ventromedial CC nucleus. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: Was originally called NPY5-R. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U58367; AAB18624.1; -; Genomic_DNA. DR EMBL; U59430; AAB19188.1; -; Genomic_DNA. DR EMBL; AK030279; BAC26875.1; -; mRNA. DR UniGene; Mm.57234; -. DR Ensembl; ENSMUSG00000038071; Mus musculus. DR MGI; MGI:1098590; Npy6r. DR GO; GO:0001601; F:peptide YY receptor activity; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000986; NeuroY6_rcpt. DR InterPro; IPR000611; NPY_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01017; NRPEPTIDEY6R. DR PRINTS; PR01012; NRPEPTIDEYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 371 Neuropeptide Y receptor type 6. FT /FTId=PRO_0000069943. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 57 1 (Potential). FT TOPO_DOM 58 69 Cytoplasmic (Potential). FT TRANSMEM 70 90 2 (Potential). FT TOPO_DOM 91 110 Extracellular (Potential). FT TRANSMEM 111 132 3 (Potential). FT TOPO_DOM 133 152 Cytoplasmic (Potential). FT TRANSMEM 153 174 4 (Potential). FT TOPO_DOM 175 208 Extracellular (Potential). FT TRANSMEM 209 230 5 (Potential). FT TOPO_DOM 231 261 Cytoplasmic (Potential). FT TRANSMEM 262 284 6 (Potential). FT TOPO_DOM 285 297 Extracellular (Potential). FT TRANSMEM 298 321 7 (Potential). FT TOPO_DOM 322 371 Cytoplasmic (Potential). FT LIPID 336 336 S-palmitoyl cysteine (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 182 182 N-linked (GlcNAc...) (Potential). FT DISULFID 109 196 By similarity. SQ SEQUENCE 371 AA; 42714 MW; E4AABB987CEB74B7 CRC64; MEVLTNQPTP NKTSGKSNNS AFFYFESCQP PFLAILLLLI AYTVILIMGI FGNLSLIIII FKKQREAQNV TNILIANLSL SDILVCVMCI PFTVIYTLMD HWVFGNTMCK LTSYVQSVSV SVSIFSLVLI AIERYQLIVN PRGWKPRVAH AYWGIILIWL ISLTLSIPLF LSYHLTNEPF HNLSLPTDIY THQVACVEIW PSKLNQLLFS TSLFMLQYFV PLGFILICYL KIVLCLRKRT RQVDRRKENK SRLNENKRVN VMLISIVVTF GACWLPLNIF NVIFDWYHEM LMSCHHDLVF VVCHLIAMVS TCINPLFYGF LNKNFQKDLM MLIHHCWCGE PQESYENIAM STMHTDESKG SLKLAHIPTG I // ID NPFF1_HUMAN STANDARD; PRT; 430 AA. AC Q9GZQ6; Q8NGR0; Q96RN3; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 18-APR-2006, entry version 37. DE Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide- DE related peptide receptor OT7T022). GN Name=NPFFR1; Synonyms=GPR147, NPFF1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Spinal cord; RX MEDLINE=20564301; PubMed=11024015; DOI=10.1074/jbc.M004385200; RA Bonini J.A., Jones K.A., Adham N., Forray C., Artymyshyn R., RA Durkin M.M., Smith K.E., Tamm J.A., Boteju L.W., Lakhlani P.P., RA Raddatz R., Yao W.-J., Ogozalek K.L., Boyle N., Kouranova E.V., RA Quan Y., Vaysse P.J., Wetzel J.M., Branchek T.A., Gerald C., RA Borowsky B.; RT "Identification and characterization of two G protein-coupled RT receptors for neuropeptide FF."; RL J. Biol. Chem. 275:39324-39331(2000). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=20482175; PubMed=11025660; DOI=10.1038/35036326; RA Hinuma S., Shintani Y., Fukusumi S., Iijima N., Matsumoto Y., RA Hosoya M., Fujii R., Watanabe T., Kikuchi K., Terao Y., Yano T., RA Yamamoto T., Kawamata Y., Habata Y., Asada M., Kitada C., Kurokawa T., RA Onda H., Nishimura O., Tanaka M., Ibata Y., Fujino M.; RT "New neuropeptides containing carboxy-terminal RFamide and their RT receptor in mammals."; RL Nat. Cell Biol. 2:703-708(2000). RN [3] RP NUCLEOTIDE SEQUENCE. RA Liu Q., Guan X.-M., McDonald T.P., Jiang Q., Zeng Z., Marlene J., RA Williams D.L. Jr., Hong Y., Figueroa D., Clements M.K., Mallee J., RA Wang R., Evans J., Gould R., Austin C.P.; RT "Identification and characterization of two cognate receptors for RT mammalian FMRFamide-like neuropeptides."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) CC neuropeptides, also known as morphine-modulating peptides. Can CC also be activated by a variety of naturally ocurring or synthetic CC FMRF-amide like ligands. This receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: Ref.4 sequence differs from that shown due to erroneous CC gene model prediction. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF268898; AAG41397.1; -; mRNA. DR EMBL; AB040104; BAB17677.1; -; mRNA. DR EMBL; AF330055; AAK94199.1; -; mRNA. DR EMBL; AB065729; BAC05950.1; ALT_SEQ; Genomic_DNA. DR UniGene; Hs.302026; -. DR Ensembl; ENSG00000148734; Homo sapiens. DR HGNC; HGNC:17425; NPFFR1. DR MIM; 607448; gene. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; NAS. DR GO; GO:0008188; F:neuropeptide receptor activity; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005395; NPFF_rcpt. DR InterPro; IPR005396; NPFF_rcpt_1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01570; NPFFRECEPTOR. DR PRINTS; PR01571; NPFFRECEPTR1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 430 Neuropeptide FF receptor 1. FT /FTId=PRO_0000069913. FT TOPO_DOM 1 43 Extracellular (Potential). FT TRANSMEM 44 64 1 (Potential). FT TOPO_DOM 65 80 Cytoplasmic (Potential). FT TRANSMEM 81 101 2 (Potential). FT TOPO_DOM 102 117 Extracellular (Potential). FT TRANSMEM 118 138 3 (Potential). FT TOPO_DOM 139 158 Cytoplasmic (Potential). FT TRANSMEM 159 179 4 (Potential). FT TOPO_DOM 180 214 Extracellular (Potential). FT TRANSMEM 215 235 5 (Potential). FT TOPO_DOM 236 271 Cytoplasmic (Potential). FT TRANSMEM 272 292 6 (Potential). FT TOPO_DOM 293 307 Extracellular (Potential). FT TRANSMEM 308 328 7 (Potential). FT TOPO_DOM 329 430 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 113 113 N-linked (GlcNAc...) (Potential). FT CARBOHYD 195 195 N-linked (GlcNAc...) (Potential). FT DISULFID 116 203 By similarity. FT CONFLICT 376 376 V -> A (in Ref. 3). SQ SEQUENCE 430 AA; 47819 MW; BBB0146281B2B9A0 CRC64; MEGEPSQPPN SSWPLSQNGT NTEATPATNL TFSSYYQHTS PVAAMFIVAY ALIFLLCMVG NTLVCFIVLK NRHMHTVTNM FILNLAVSDL LVGIFCMPTT LVDNLITGWP FDNATCKMSG LVQGMSVSAS VFTLVAIAVE RFRCIVHPFR EKLTLRKALV TIAVIWALAL LIMCPSAVTL TVTREEHHFM VDARNRSYPL YSCWEAWPEK GMRRVYTTVL FSHIYLAPLA LIVVMYARIA RKLCQAPGPA PGGEEAADPR ASRRRARVVH MLVMVALFFT LSWLPLWALL LLIDYGQLSA PQLHLVTVYA FPFAHWLAFF NSSANPIIYG YFNENFRRGF QAAFRARLCP RPSGSHKEAY SERPGGLLHR RVFVVVRPSD SGLPSESGPS SGAPRPGRLP LRNGRVAHHG LPREGPGCSH LPLTIPAWDI // ID OX1R_MOUSE STANDARD; PRT; 416 AA. AC P58307; Q3USS9; Q6VNS3; Q80T45; DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot. DT 06-DEC-2005, sequence version 2. DT 02-MAY-2006, entry version 35. DE Orexin receptor type 1 (Ox1r) (Hypocretin receptor type 1). GN Name=Hcrtr1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC STRAIN=BALB/c; TISSUE=Brain; RX PubMed=15256537; DOI=10.1210/me.2004-0167; RA Chen J., Randeva H.S.; RT "Genomic organization of mouse orexin receptors: characterization of RT two novel tissue-specific splice variants."; RL Mol. Endocrinol. 18:2790-2804(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 134-393. RC STRAIN=C57BL/6; RA Szendro P.I., Maevers K., Eichele G.; RT "Cloning of mouse orexin receptors."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-339. RX MEDLINE=22584407; PubMed=12679517; DOI=10.1073/pnas.0230374100; RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., RA Bergmann J.E., Gaitanaris G.A.; RT "The G protein-coupled receptor repertoires of human and mouse."; RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003). RN [5] RP REVIEW. RX MEDLINE=21237974; PubMed=11340621; DOI=10.1002/bies.1058; RA Hungs M., Mignot E.; RT "Hypocretin/orexin, sleep and narcolepsy."; RL Bioessays 23:397-408(2001). RN [6] RP REVIEW. RX MEDLINE=21178476; PubMed=11283317; DOI=10.1146/annurev.neuro.24.1.429; RA Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.; RT "To eat or to sleep? Orexin in the regulation of feeding and RT wakefulness."; RL Annu. Rev. Neurosci. 24:429-458(2001). CC -!- FUNCTION: Moderately selective excitatory receptor for orexin-A CC and, with a lower affinity, for orexin-B neuropeptide. Seems to be CC exclusively coupled to the G(q) subclass of heteromeric G CC proteins, which activates the phospholipase C mediated signaling CC cascade (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Widely expressed. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY336083; AAR01326.1; -; mRNA. DR EMBL; AK140137; BAE24252.1; -; mRNA. DR EMBL; AF394596; AAK71326.1; -; mRNA. DR EMBL; AY255599; AAO85111.1; -; mRNA. DR UniGene; Mm.246595; -. DR Ensembl; ENSMUSG00000028778; Mus musculus. DR MGI; MGI:2385650; Hcrtr1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000204; Orexin_rcpt. DR InterPro; IPR004059; Orexin_rcpt_1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01521; OREXIN1R. DR PRINTS; PR01064; OREXINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 416 Orexin receptor type 1. FT /FTId=PRO_0000069985. FT TOPO_DOM 1 46 Extracellular (Potential). FT TRANSMEM 47 67 1 (Potential). FT TOPO_DOM 68 83 Cytoplasmic (Potential). FT TRANSMEM 84 104 2 (Potential). FT TOPO_DOM 105 120 Extracellular (Potential). FT TRANSMEM 121 141 3 (Potential). FT TOPO_DOM 142 162 Cytoplasmic (Potential). FT TRANSMEM 163 183 4 (Potential). FT TOPO_DOM 184 218 Extracellular (Potential). FT TRANSMEM 219 239 5 (Potential). FT TOPO_DOM 240 299 Cytoplasmic (Potential). FT TRANSMEM 300 320 6 (Potential). FT TOPO_DOM 321 336 Extracellular (Potential). FT TRANSMEM 337 357 7 (Potential). FT TOPO_DOM 358 416 Cytoplasmic (Potential). FT CARBOHYD 194 194 N-linked (GlcNAc...) (Potential). FT CONFLICT 139 139 F -> V (in Ref. 3). FT CONFLICT 232 232 G -> A (in Ref. 2). SQ SEQUENCE 416 AA; 46767 MW; A8958C594C365E00 CRC64; MEPSATPGAQ PGVPTSSGEP FHLPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFLIA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGQALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAVMVPQA AVMECSSVLP ELANRTRLFS VCDEHWADEL YPKIYHSCFF IVTYLAPLGL MGMAYFQIFR KLWGRQIPGT TSALVRNWKR PSEQLEAQHQ GLCTEPQPRA RAFLAEVKQM RARRKTAKML MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPGSSARHKS LSLQSRCSVS KVSEHVVLTT VTTVLS // ID NK1R_CANFA STANDARD; PRT; 407 AA. AC Q5DUB3; DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 29-MAR-2005, sequence version 1. DT 02-MAY-2006, entry version 12. DE Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin DE receptor 1). GN Name=TACR1; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Engberg S., Drmota T.; RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide CC substance P. It is probably associated with G proteins that CC activate a phosphatidylinositol-calcium second messenger system CC (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AJ884915; CAI58656.1; -; mRNA. DR UniGene; Cfa.3677; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001681; Neurokn_rcpt. DR InterPro; IPR000046; NK1_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01024; NEUROKININ1R. DR PRINTS; PR00244; NEUROKININR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 407 Substance-P receptor. FT /FTId=PRO_0000069883. FT TOPO_DOM 1 31 Extracellular (Potential). FT TRANSMEM 32 54 1 (Potential). FT TOPO_DOM 55 64 Cytoplasmic (Potential). FT TRANSMEM 65 86 2 (Potential). FT TOPO_DOM 87 106 Extracellular (Potential). FT TRANSMEM 107 128 3 (Potential). FT TOPO_DOM 129 148 Cytoplasmic (Potential). FT TRANSMEM 149 169 4 (Potential). FT TOPO_DOM 170 194 Extracellular (Potential). FT TRANSMEM 195 219 5 (Potential). FT TOPO_DOM 220 248 Cytoplasmic (Potential). FT TRANSMEM 249 270 6 (Potential). FT TOPO_DOM 271 283 Extracellular (Potential). FT TRANSMEM 284 308 7 (Potential). FT TOPO_DOM 309 407 Cytoplasmic (Potential). FT LIPID 322 322 S-palmitoyl cysteine (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT DISULFID 105 180 By similarity. SQ SEQUENCE 407 AA; 46464 MW; 18C8F4EA4FBF4F14 CRC64; MDNVLQVDSD LFPNISTNTS EPNQFVQPAW QIVLWAAAYT VIVVTSVVGN VVVMWIILAH KRMRTVTNYF LVNLAFAEAS MAAFNTVVNF TYAVHNEWYY GLFYCKFHNF FPIAAVFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV ICVIWVLALL LAFPQGYYST TETMPNRVVC MIEWPEHPNK IYEKVYHICV TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM IVVVCTFAIC WLPFHIFFLL PYINPDLYLE KFIQQVYLAI MWLAMSSTMY NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQGSVYK VSRLETTVST VVGAHEEELE DGPKTTPSSL DLTSNGSSRS DSKTMTESFS FYSNMLS // ID NK3R_HUMAN STANDARD; PRT; 465 AA. AC P29371; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-1992, sequence version 1. DT 18-APR-2006, entry version 55. DE Neuromedin K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) DE (NK-3R) (Tachykinin receptor 3). GN Name=TACR3; Synonyms=NK3R, TAC3R; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=92246993; PubMed=1374246; RA Huang R.-R.C., Cheung A.H., Mazina K.E., Strader C.D., Fong T.M.; RT "cDNA sequence and heterologous expression of the human neurokinin-3 RT receptor."; RL Biochem. Biophys. Res. Commun. 184:966-972(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=92183914; PubMed=1312036; DOI=10.1016/0014-5793(92)80107-R; RA Buell G., Schulz M.F., Arkinstall S.J., Maury K., Missotten M., RA Adami N., Talabot F., Kawashima E.; RT "Molecular characterisation, expression and localisation of human RT neurokinin-3 receptor."; RL FEBS Lett. 299:90-95(1992). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Placenta; RX MEDLINE=92201186; PubMed=1312928; RA Takahashi K., Tanaka A., Hara M., Nakanishi S.; RT "The primary structure and gene organization of human substance P and RT neuromedin K receptors."; RL Eur. J. Biochem. 204:1025-1033(1992). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide CC neuromedin K (neurokinin B). It is associated with G proteins that CC activate a phosphatidylinositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: The anchoring of this receptor to the plasma membrane is CC probably mediated by the palmitoylation of a cysteine residue. CC -!- MISCELLANEOUS: The rank order of affinity of this receptor to CC tachykinins is: neuromedin K > substance K > substance P. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M89473; AAA36366.1; -; mRNA. DR EMBL; S86392; AAB21706.1; -; Genomic_DNA. DR EMBL; S86371; AAB21706.1; JOINED; Genomic_DNA. DR EMBL; S86382; AAB21706.1; JOINED; Genomic_DNA. DR EMBL; S86388; AAB21706.1; JOINED; Genomic_DNA. DR EMBL; S86390; AAB21706.1; JOINED; Genomic_DNA. DR EMBL; X65172; CAA46291.1; -; Genomic_DNA. DR EMBL; X65173; CAA46291.1; JOINED; Genomic_DNA. DR EMBL; X65174; CAA46291.1; JOINED; Genomic_DNA. DR EMBL; X65175; CAA46291.1; JOINED; Genomic_DNA. DR EMBL; X65176; CAA46291.1; JOINED; Genomic_DNA. DR EMBL; AY462099; AAR23926.1; -; mRNA. DR PIR; JQ1517; JQ1517. DR UniGene; Hs.942; -. DR HSSP; P02699; 1F88. DR Ensembl; ENSG00000169836; Homo sapiens. DR HGNC; HGNC:11528; TACR3. DR MIM; 162332; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004995; F:tachykinin receptor activity; TAS. DR GO; GO:0007217; P:tachykinin signaling pathway; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001681; Neurokn_rcpt. DR InterPro; IPR001013; NK3_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01026; NEUROKININ3R. DR PRINTS; PR00244; NEUROKININR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 465 Neuromedin K receptor. FT /FTId=PRO_0000069899. FT TOPO_DOM 1 84 Extracellular (Potential). FT TRANSMEM 85 107 1 (Potential). FT TOPO_DOM 108 117 Cytoplasmic (Potential). FT TRANSMEM 118 139 2 (Potential). FT TOPO_DOM 140 159 Extracellular (Potential). FT TRANSMEM 160 181 3 (Potential). FT TOPO_DOM 182 201 Cytoplasmic (Potential). FT TRANSMEM 202 222 4 (Potential). FT TOPO_DOM 223 245 Extracellular (Potential). FT TRANSMEM 246 270 5 (Potential). FT TOPO_DOM 271 299 Cytoplasmic (Potential). FT TRANSMEM 300 321 6 (Potential). FT TOPO_DOM 322 334 Extracellular (Potential). FT TRANSMEM 335 359 7 (Potential). FT TOPO_DOM 360 465 Cytoplasmic (Potential). FT LIPID 374 374 S-palmitoyl cysteine (Potential). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT CARBOHYD 50 50 N-linked (GlcNAc...) (Potential). FT CARBOHYD 73 73 N-linked (GlcNAc...) (Potential). FT DISULFID 158 233 By similarity. FT CONFLICT 3 3 T -> I (in Ref. 2). FT CONFLICT 63 63 A -> R (in Ref. 2). FT CONFLICT 439 439 C -> F (in Ref. 3). SQ SEQUENCE 465 AA; 52202 MW; 98E88D4BC9DBD315 CRC64; MATLPAAETW IDGGGGVGAD AVNLTASLAA GAATGAVETG WLQLLDQAGN LSSSPSALGL PVASPAPSQP WANLTNQFVQ PSWRIALWSL AYGVVVAVAV LGNLIVIWII LAHKRMRTVT NYFLVNLAFS DASMAAFNTL VNFIYALHSE WYFGANYCRF QNFFPITAVF ASIYSMTAIA VDRYMAIIDP LKPRLSATAT KIVIGSIWIL AFLLAFPQCL YSKTKVMPGR TLCFVQWPEG PKQHFTYHII VIILVYCFPL LIMGITYTIV GITLWGGEIP GDTCDKYHEQ LKAKRKVVKM MIIVVMTFAI CWLPYHIYFI LTAIYQQLNR WKYIQQVYLA SFWLAMSSTM YNPIIYCCLN KRFRAGFKRA FRWCPFIKVS SYDELELKTT RFHPNRQSSM YTVTRMESMT VVFDPNDADT TRSSRKKRAT PRDPSFNGCS RRNSKSASAT SSFISSPYTS VDEYS // ID TLR2_DROME STANDARD; PRT; 519 AA. AC P30975; Q8T0S8; Q9VAD2; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 21-JUN-2005, sequence version 2. DT 04-APR-2006, entry version 49. DE Tachykinin-like peptides receptor 99D (dTKR). GN Name=Takr99D; ORFNames=CG7887; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Canton-S; RX MEDLINE=92007772; PubMed=1717263; RA Li X.-J., Wolfgang W., Wu Y.-N., North R.A., Forte M.A.; RT "Cloning, heterologous expression and developmental regulation of a RT Drosophila receptor for tachykinin-like peptides."; RL EMBO J. 10:3221-3229(1991). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Head; RX MEDLINE=22426066; PubMed=12537569; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., RA Rubin G.M., Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). CC -!- FUNCTION: Probable receptor for tachykinin-like peptides. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X62711; CAA44595.1; -; mRNA. DR EMBL; AE003771; AAF56979.2; -; Genomic_DNA. DR EMBL; AY069085; AAL39230.1; -; mRNA. DR PIR; S17783; S17783. DR UniGene; Dm.1374; -. DR Ensembl; CG7887; Drosophila melanogaster. DR FlyBase; FBgn0004622; Takr99D. DR GO; GO:0004995; F:tachykinin receptor activity; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001681; Neurokn_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00244; NEUROKININR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Complete proteome; G-protein coupled receptor; Glycoprotein; KW Lipoprotein; Membrane; Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 519 Tachykinin-like peptides receptor 99D. FT /FTId=PRO_0000070185. FT TOPO_DOM 1 100 Extracellular (Potential). FT TRANSMEM 101 123 1 (Potential). FT TOPO_DOM 124 134 Cytoplasmic (Potential). FT TRANSMEM 135 155 2 (Potential). FT TOPO_DOM 156 175 Extracellular (Potential). FT TRANSMEM 176 197 3 (Potential). FT TOPO_DOM 198 217 Cytoplasmic (Potential). FT TRANSMEM 218 238 4 (Potential). FT TOPO_DOM 239 270 Extracellular (Potential). FT TRANSMEM 271 292 5 (Potential). FT TOPO_DOM 293 324 Cytoplasmic (Potential). FT TRANSMEM 325 346 6 (Potential). FT TOPO_DOM 347 361 Extracellular (Potential). FT TRANSMEM 362 384 7 (Potential). FT TOPO_DOM 385 519 Cytoplasmic (Potential). FT COMPBIAS 471 481 Gly/Ser-rich. FT LIPID 399 399 S-palmitoyl cysteine (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT CARBOHYD 61 61 N-linked (GlcNAc...) (Potential). FT DISULFID 174 254 By similarity. FT CONFLICT 46 58 LPDFGQELALSTS -> CRTLARSSPYPPV (in Ref. FT 1). FT CONFLICT 345 345 I -> T (in Ref. 4). FT CONFLICT 456 457 Missing (in Ref. 4). SQ SEQUENCE 519 AA; 58396 MW; 57105170D4CA5AA5 CRC64; MENRSDFEAD DYGDISWSNW SNWSTPAGVL FSAMSSVLSA SNHTPLPDFG QELALSTSSF NHSQTLSTDL PAVGDVEDAA EDAAASMETG SFAFVVPWWR QVLWSILFGG MVIVATGGNL IVVWIVMTTK RMRTVTNYFI VNLSIADAMV SSLNVTFNYY YMLDSDWPFG EFYCKLSQFI AMLSICASVF TLMAISIDRY VAIIRPLQPR MSKRCNLAIA AVIWLASTLI SCPMMIIYRT EEVPVRGLSN RTVCYPEWPD GPTNHSTMES LYNILIIILT YFLPIVSMTV TYSRVGIELW GSKTIGECTP RQVENVRSKR RVVKMMIVVV LIFAICWLPF HSYFIITSCY PAITEAPFIQ ELYLAIYWLA MSNSMYNPII YCWMNSRFRY GFKMVFRWCL FVRVGTEPFS RRENLTSRYS CSGSPDHNRI KRNDTQKSIL YTCPSSPKSH RISHSGTGRS ATLRNSLPAE SLSSGGSGGG GHRKRLSYQQ EMQQRWSGPN SATAVTNSSS TANTTQLLS // ID NMUR1_HUMAN STANDARD; PRT; 426 AA. AC Q9HB89; O43664; Q7LDP6; Q8NE20; DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 18-APR-2006, entry version 31. DE Neuromedin U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G- DE protein coupled receptor FM-3). GN Name=NMUR1; Synonyms=GPR66; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY. RX MEDLINE=20490668; PubMed=10899166; DOI=10.1074/jbc.M004613200; RA Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B., RA Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., RA Dai M., Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., RA Adham N.; RT "Identification and characterization of two neuromedin U receptors RT differentially expressed in peripheral tissues and the central nervous RT system."; RL J. Biol. Chem. 275:32452-32459(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PNS, and Testis; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-426, AND TISSUE SPECIFICITY. RX MEDLINE=99000845; PubMed=9782091; DOI=10.1006/geno.1998.5441; RA Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., RA Hreniuk D.L., Smith R.G., Howard A.D.; RT "Cloning and characterization of a human and murine T-cell orphan G- RT protein-coupled receptor similar to the growth hormone secretagogue RT and neurotensin receptors."; RL Genomics 52:223-229(1998). CC -!- FUNCTION: Receptor for the neuromedin U neuropeptide. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in greatest abundance in peripheral CC organs, particularly in elements of the gastrointestinal and CC urogenital systems with highest levels in testes. In central CC nervous system structures express levels are much lower than those CC seen in peripheral organs. Within the CNS, has been detected in CC highest abundance in the cerebellum, dorsal root ganglia, CC hippocampus, and spinal cord. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: It is uncertain whether Met-1 or Met-24 is the initiator. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF272362; AAG24793.1; -; mRNA. DR EMBL; AC017104; AAY24249.1; -; Genomic_DNA. DR EMBL; BC036543; AAH36543.1; -; mRNA. DR EMBL; BC051914; AAH51914.1; -; mRNA. DR EMBL; AF044601; AAC02680.1; -; Genomic_DNA. DR EMBL; AF044600; AAC02680.1; JOINED; Genomic_DNA. DR UniGene; Hs.471619; -. DR Ensembl; ENSG00000171596; Homo sapiens. DR HGNC; HGNC:4518; NMUR1. DR MIM; 604153; gene. DR GO; GO:0016021; C:integral to membrane; IDA. DR GO; GO:0005624; C:membrane fraction; IDA. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0001607; F:neuromedin U receptor activity; IDA. DR GO; GO:0006816; P:calcium ion transport; IDA. DR GO; GO:0019722; P:calcium-mediated signaling; IDA. DR GO; GO:0006821; P:chloride transport; IDA. DR GO; GO:0048016; P:inositol phosphate-mediated signaling; IDA. DR GO; GO:0007218; P:neuropeptide signaling pathway; TAS. DR GO; GO:0007202; P:phospholipase C activation; IDA. DR GO; GO:0045045; P:secretory pathway; IEP. DR GO; GO:0006939; P:smooth muscle contraction; IEP. DR GO; GO:0019226; P:transmission of nerve impulse; IEP. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR005390; NeuromedU_rcpt. DR InterPro; IPR005391; NeuromedU_rcpt_1. DR PANTHER; PTHR19264:SF55; NeuromedinU1; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01565; NEUROMEDINUR. DR PRINTS; PR01566; NEUROMEDNU1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 426 Neuromedin U receptor 1. FT /FTId=PRO_0000069906. FT TOPO_DOM 1 65 Extracellular (Potential). FT TRANSMEM 66 86 1 (Potential). FT TOPO_DOM 87 97 Cytoplasmic (Potential). FT TRANSMEM 98 118 2 (Potential). FT TOPO_DOM 119 138 Extracellular (Potential). FT TRANSMEM 139 161 3 (Potential). FT TOPO_DOM 162 181 Cytoplasmic (Potential). FT TRANSMEM 182 202 4 (Potential). FT TOPO_DOM 203 235 Extracellular (Potential). FT TRANSMEM 236 256 5 (Potential). FT TOPO_DOM 257 294 Cytoplasmic (Potential). FT TRANSMEM 295 315 6 (Potential). FT TOPO_DOM 316 338 Extracellular (Potential). FT TRANSMEM 339 359 7 (Potential). FT TOPO_DOM 360 426 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 27 27 N-linked (GlcNAc...) (Potential). FT CARBOHYD 41 41 N-linked (GlcNAc...) (Potential). FT DISULFID 134 219 By similarity. FT CONFLICT 203 203 R -> Q (in Ref. 3; AAH36543). SQ SEQUENCE 426 AA; 47351 MW; F8DD781C020F04AA CRC64; MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK YLGPQQTELF MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF SLAVSDLLVL LVGLPLELYE MWHNYPFLLG VGGCYFRTLL FEMVCLASVL NVTALSVERY VAVVHPLQAR SMVTRAHVRR VLGAVWGLAM LCSLPNTSLH GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF CLPMAIMSVL YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA ANPVLYSLMS SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD VGSLGSWVHP LAGNDGPEAQ QETDPS // ID NTR1_MOUSE STANDARD; PRT; 424 AA. AC O88319; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 18-APR-2006, entry version 44. DE Neurotensin receptor type 1 (NT-R-1). GN Name=Ntsr1; Synonyms=Ntsr; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RA Snider J., Sano H., Ohta M.; RT "Neurotensin receptor type 1."; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for the tridecapeptide neurotensin. It is CC associated with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB017027; BAA33013.1; -; mRNA. DR UniGene; Mm.301712; -. DR Ensembl; ENSMUSG00000027568; Mus musculus. DR MGI; MGI:97386; Ntsr1. DR GO; GO:0008188; F:neuropeptide receptor activity; TAS. DR GO; GO:0008344; P:adult locomotory behavior; IGI. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR003985; NT1_rcpt. DR InterPro; IPR003984; NT_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01479; NEUROTENSINR. DR PRINTS; PR01480; NEUROTENSN1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 424 Neurotensin receptor type 1. FT /FTId=PRO_0000069947. FT TOPO_DOM 1 64 Extracellular (Potential). FT TRANSMEM 65 87 1 (Potential). FT TOPO_DOM 88 96 Cytoplasmic (Potential). FT TRANSMEM 97 121 2 (Potential). FT TOPO_DOM 122 143 Extracellular (Potential). FT TRANSMEM 144 165 3 (Potential). FT TOPO_DOM 166 188 Cytoplasmic (Potential). FT TRANSMEM 189 210 4 (Potential). FT TOPO_DOM 211 235 Extracellular (Potential). FT TRANSMEM 236 260 5 (Potential). FT TOPO_DOM 261 308 Cytoplasmic (Potential). FT TRANSMEM 309 330 6 (Potential). FT TOPO_DOM 331 348 Extracellular (Potential). FT TRANSMEM 349 372 7 (Potential). FT TOPO_DOM 373 424 Cytoplasmic (Potential). FT LIPID 388 388 S-palmitoyl cysteine (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). FT CARBOHYD 42 42 N-linked (GlcNAc...) (Potential). FT CARBOHYD 211 211 N-linked (GlcNAc...) (Potential). FT DISULFID 141 224 By similarity. SQ SEQUENCE 424 AA; 47217 MW; 8E9A723171A48711 CRC64; MHLNSSVQQG APSEPGAQPF PHPQFGLETM LLALSLSNGS GNSSESILEP NSNLDVNTDI YSKVLVTAVY LALFVVGTVG NSVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLILLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA VPMLFTMGLQ NRSADGQHPG GLVCTPTVDT ATVKVVIQVN TFMSFLFPML IISILNTVIA NKLTVMVHQA AEQGRGVCTV GTHNSLEHST FNMSIEPGRV QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRRRRKKRPT FSRKPNSMSS NHAFSTSATR ETLY // ID GASR_HUMAN STANDARD; PRT; 447 AA. AC P32239; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 18-APR-2006, entry version 59. DE Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) DE (Cholecystokinin-2 receptor) (CCK2-R). GN Name=CCKBR; Synonyms=CCKRB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RX MEDLINE=93216795; PubMed=7681836; RA Lee Y.-M., Beinborn M., McBride E.W., Lu M., Kolakowski L.F. Jr., RA Kopin A.S.; RT "The human brain cholecystokinin-B/gastrin receptor. Cloning and RT characterization."; RL J. Biol. Chem. 268:8164-8169(1993). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RX MEDLINE=93080572; PubMed=1280419; RA Pisegna J.R., de Weerth A., Huppi K., Wank S.A.; RT "Molecular cloning of the human brain and gastric cholecystokinin RT receptor: structure, functional expression and chromosomal RT localization."; RL Biochem. Biophys. Res. Commun. 189:296-303(1992). RN [3] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta; RX MEDLINE=94022320; PubMed=8415658; RA Song I., Brown D.R., Wiltshire R.N., Gantz I., Trent J.M., Yamada T.; RT "The human gastrin/cholecystokinin type B receptor gene: alternative RT splice donor site in exon 4 generates two variant mRNAs."; RL Proc. Natl. Acad. Sci. U.S.A. 90:9085-9089(1993). RN [4] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RX MEDLINE=93352657; PubMed=8349705; RA Ito M., Matsui T., Taniguchi T., Tsukamoto T., Murayama T., Arima N., RA Nakata H., Chiba T., Chihara K.; RT "Functional characterization of a human brain cholecystokinin-B RT receptor. A trophic effect of cholecystokinin and gastrin."; RL J. Biol. Chem. 268:18300-18305(1993). RN [5] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Temporal cortex; RA Tate S.N., Gray J., Denyer J., Stolz M., Foord S., Lee M.G.; RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [8] RP STRUCTURE BY NMR OF 351-380. RX PubMed=11926817; DOI=10.1021/bi0160009; RA Giragossian C., Mierke D.F.; RT "Intermolecular interactions between cholecystokinin-8 and the third RT extracellular loop of the cholecystokinin-2 receptor."; RL Biochemistry 41:4560-4566(2002). CC -!- FUNCTION: Receptor for gastrin and cholecystokinin. The CKK-B CC receptors occur throughout the central nervous system where they CC modulate anxiety, analgesia, arousal, and neuroleptic activity. CC This receptor mediates its action by association with G proteins CC that activate a phosphatidylinositol-calcium second messenger CC system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L08112; AAA35657.1; -; mRNA. DR EMBL; L04473; AAA35660.1; -; mRNA. DR EMBL; L10822; AAC37528.1; -; Unassigned_DNA. DR EMBL; D13305; BAA02564.1; -; mRNA. DR EMBL; L07746; AAA91831.1; -; mRNA. DR EMBL; AY322551; AAP84364.1; -; mRNA. DR EMBL; BT006789; AAP35435.1; -; mRNA. DR PIR; A47430; A47430. DR UniGene; Hs.203; -. DR PDB; 1L4T; NMR; A=352-379. DR Ensembl; ENSG00000110148; Homo sapiens. DR H-InvDB; HIX0009396; -. DR HGNC; HGNC:1571; CCKBR. DR MIM; 118445; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004951; F:cholecystokinin receptor activity; TAS. DR GO; GO:0046935; F:phosphatidylinositol 3-kinase regulator act...; TAS. DR GO; GO:0004435; F:phosphoinositide phospholipase C activity; TAS. DR GO; GO:0008283; P:cell proliferation; TAS. DR GO; GO:0007166; P:cell surface receptor linked signal transdu...; TAS. DR GO; GO:0007586; P:digestion; TAS. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS. DR GO; GO:0007631; P:feeding behavior; TAS. DR GO; GO:0007202; P:phospholipase C activation; TAS. DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS. DR GO; GO:0007600; P:sensory perception; TAS. DR InterPro; IPR009126; Cholcskin_rcpt. DR InterPro; IPR000314; Gastrin_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01822; CCYSTOKININR. DR PRINTS; PR00527; GASTRINR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW 3D-structure; G-protein coupled receptor; Glycoprotein; Lipoprotein; KW Membrane; Palmitate; Polymorphism; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 447 Gastrin/cholecystokinin type B receptor. FT /FTId=PRO_0000069474. FT TOPO_DOM 1 57 Extracellular (Potential). FT TRANSMEM 58 79 1 (Potential). FT TOPO_DOM 80 87 Cytoplasmic (Potential). FT TRANSMEM 88 109 2 (Potential). FT TOPO_DOM 110 131 Extracellular (Potential). FT TRANSMEM 132 150 3 (Potential). FT TOPO_DOM 151 170 Cytoplasmic (Potential). FT TRANSMEM 171 189 4 (Potential). FT TOPO_DOM 190 219 Extracellular (Potential). FT TRANSMEM 220 242 5 (Potential). FT TOPO_DOM 243 333 Cytoplasmic (Potential). FT TRANSMEM 334 355 6 (Potential). FT TOPO_DOM 356 373 Extracellular (Potential). FT TRANSMEM 374 394 7 (Potential). FT TOPO_DOM 395 447 Cytoplasmic (Potential). FT LIPID 408 408 S-palmitoyl cysteine (By similarity). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 30 30 N-linked (GlcNAc...) (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT DISULFID 127 205 By similarity. FT VARIANT 37 37 L -> F (in dbSNP:1805000). FT /FTId=VAR_014684. FT VARIANT 125 125 V -> I (in dbSNP:1805002). FT /FTId=VAR_014685. FT VARIANT 215 215 R -> H (in dbSNP:1805004). FT /FTId=VAR_014686. FT VARIANT 319 319 R -> Q (in dbSNP:1805001). FT /FTId=VAR_014687. FT CONFLICT 171 171 A -> P (in Ref. 5). FT CONFLICT 249 249 L -> V (in Ref. 5). FT HELIX 353 358 FT STRAND 359 359 FT HELIX 363 368 FT STRAND 369 370 FT HELIX 372 378 SQ SEQUENCE 447 AA; 48419 MW; BAEEFAD4C1F85915 CRC64; MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR ELELAIRITL YAVIFLMSVG GNMLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF IFGTVICKAV SYLMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIVATWL LSGLLMVPYP VYTVVQPVGP RVLQCVHRWP SARVRQTWSV LLLLLLFFIP GVVMAVAYGL ISRELYLGLR FDGDSDSDSQ SRVRNQGGLP GAVHQNGRCR PETGAVGEDS DGCYVQLPRS RPALELTALT APGPGSGSRP TQAKLLAKKR VVRMLLVIVV LFFLCWLPVY SANTWRAFDG PGAHRALSGA PISFIHLLSY ASACVNPLVY CFMHRRFRQA CLETCARCCP RPPRARPRAL PDEDPPTPSI ASLSRLSYTT ISTLGPG // ID CCKAR_CAVPO STANDARD; PRT; 430 AA. AC Q63931; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 07-MAR-2006, entry version 42. DE Cholecystokinin type A receptor (CCK-A receptor) (CCK-AR) DE (Cholecystokinin-1 receptor) (CCK1-R). GN Name=CCKAR; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Gall bladder, and Pancreas; RX MEDLINE=94106629; PubMed=7916580; RA de Weerth A., Pisegna J.R., Wank S.A.; RT "Guinea pig gallbladder and pancreas possess identical CCK-A receptor RT subtypes: receptor cloning and expression."; RL Am. J. Physiol. 265:G1116-G1121(1993). CC -!- FUNCTION: Receptor for cholecystokinin. Mediates pancreatic growth CC and enzyme secretion, smooth muscle contraction of the gall CC bladder and stomach. Has a 1000-fold higher affinity for CCK CC rather than for gastrin. It modulates feeding and dopamine-induced CC behavior in the central and peripheral nervous system. This CC receptor mediates its action by association with G proteins that CC activate a phosphatidylinositol-calcium second messenger system CC (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; S68242; AAB29504.1; -; mRNA. DR PIR; I51898; I51898. DR HSSP; P32238; 1HZN. DR SMR; Q63931; 1-47. DR InterPro; IPR009126; Cholcskin_rcpt. DR InterPro; IPR000596; Cholcy_rcpt_A. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01822; CCYSTOKININR. DR PRINTS; PR00524; CCYSTOKNINAR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 430 Cholecystokinin type A receptor. FT /FTId=PRO_0000069222. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 67 1 (Potential). FT TOPO_DOM 68 77 Cytoplasmic (Potential). FT TRANSMEM 78 104 2 (Potential). FT TOPO_DOM 105 115 Extracellular (Potential). FT TRANSMEM 116 137 3 (Potential). FT TOPO_DOM 138 157 Cytoplasmic (Potential). FT TRANSMEM 158 178 4 (Potential). FT TOPO_DOM 179 210 Extracellular (Potential). FT TRANSMEM 211 234 5 (Potential). FT TOPO_DOM 235 315 Cytoplasmic (Potential). FT TRANSMEM 316 336 6 (Potential). FT TOPO_DOM 337 351 Extracellular (Potential). FT TRANSMEM 352 375 7 (Potential). FT TOPO_DOM 376 430 Cytoplasmic (Potential). FT LIPID 389 389 S-palmitoyl cysteine (By similarity). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 190 190 N-linked (GlcNAc...) (Potential). FT DISULFID 18 29 By similarity. FT DISULFID 114 196 By similarity. SQ SEQUENCE 430 AA; 48211 MW; FC9F5D34032076C9 CRC64; MDVVDSLFVN GSNITSACEL GFENETLFCL DRPRPSKEWQ PAVQILLYSL IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI PSLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICKPLQSR VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTGNMCRFLL PNDVMQQTWH TFLLLILFLI PGIVMMVAYG LISLELYQGI KFDAIQKKSA KERKTSTGSS GPMEDSDGCY LQKSRHPRKL ELRQLSPSSS GSNRINRIRS SSSTANLMAK KRVIRMLIVI VVLFFLCWMP IFSANAWRAY DTVSAERHLS GTPISFILLL SYTSSCVNPI IYCFMNKRFR LGFMATFPCC PNPGTPGVRG EMGEEEEGRT TGASLSRYSY SHMSTSAPPP // ID AVT_CATCO STANDARD; PRT; 434 AA. AC Q90352; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 21-MAR-2006, entry version 38. DE [Arg8]vasotocin receptor (AVT). OS Catostomus commersoni (White sucker). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Catostomidae; Catostomus. OX NCBI_TaxID=7971; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=94151326; PubMed=7509069; RA Mahlmann S., Meyerhof W., Hausmann H., Heierhorst J., Schoenrock C., RA Zwiers H., Lederis K., Richter D.; RT "Structure, function, and phylogeny of [Arg8]vasotocin receptors from RT teleost fish and toad."; RL Proc. Natl. Acad. Sci. U.S.A. 91:1342-1345(1994). CC -!- FUNCTION: Binds to vasotocin. Produces an induction of membrane CC chloride currents indicating that it is coupled to the inositol CC phosphate/calcium pathway. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in pituitary, liver, gills, swim CC bladder and lateral line. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X76321; CAA53958.1; -; mRNA. DR PIR; I50132; I50132. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001817; Vasoprsn_rcpt. DR InterPro; IPR001224; Vprs_V1A_rcpt. DR PANTHER; PTHR19264:SF32; Vprs_receptorV1A; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PRINTS; PR00752; VASOPRSNV1AR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 434 [Arg8]vasotocin receptor. FT /FTId=PRO_0000069178. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 48 1 (Potential). FT TOPO_DOM 49 67 Cytoplasmic (Potential). FT TRANSMEM 68 88 2 (Potential). FT TOPO_DOM 89 98 Extracellular (Potential). FT TRANSMEM 99 119 3 (Potential). FT TOPO_DOM 120 141 Cytoplasmic (Potential). FT TRANSMEM 142 162 4 (Potential). FT TOPO_DOM 163 191 Extracellular (Potential). FT TRANSMEM 192 212 5 (Potential). FT TOPO_DOM 213 257 Cytoplasmic (Potential). FT TRANSMEM 258 278 6 (Potential). FT TOPO_DOM 279 295 Extracellular (Potential). FT TRANSMEM 296 316 7 (Potential). FT TOPO_DOM 317 434 Cytoplasmic (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT DISULFID 97 176 By similarity. SQ SEQUENCE 434 AA; 49498 MW; 2C2A4A49EE1C2BA5 CRC64; MGRIANQTTA SNDTDPFGRN EEVAKMEITV LSVTFFVAVI GNLSVLLAMH NTKKKSSRMH LFIKHLSLAD MVVAFFQVLP QLCWEITFRF YGPDFLCRIV KHLQVLGMFA STYMMVMMTL DRYIAICHPL KTLQQPTQRA YIMIGSTWLC SLLLSTPQYF IFSLSEIQNG SYVYDCWGHF IEPWGIRAYI TWITVGIFLI PVIILMICYG FICHSIWKNI KCKTMRGTRN TKDGMIGKVS VSSVTIISRA KLRTVKMTLV IVLAYIVCWA PFFIVQMWSV WDENFSWDDS ENAAVTLSAL LASLNSCCNP WIYMLFSGHL LYDFLRCFPC CKKPRNMLQK EDSDSSIRRN TLLTKLAAGR MTNDGFGSWR DPCNSRKSSQ SIGLDCFCKS SQCLEHDCSR KSSQCIPLDC SRKSSQCIPL DCSRKSSQCM SKES // ID MTR_BUFMA STANDARD; PRT; 389 AA. AC Q90252; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 21-MAR-2006, entry version 37. DE Mesotocin receptor (MTR). OS Bufo marinus (Giant toad) (Cane toad). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Bufo. OX NCBI_TaxID=8386; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Urinary bladder; RX MEDLINE=96235243; PubMed=8647123; RA Akhundova A., Getmanova E., Gorboulev V., Garnazzi E., Eggena P., RA Fahrenholz F.; RT "Cloning and functional characterization of the amphibian mesotocin RT receptor, a member of the oxytocin/vasopressin receptor superfamily."; RL Eur. J. Biochem. 237:759-767(1996). CC -!- FUNCTION: Binds to mesotocin and may play a role in the regulation CC of water and salt transport. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Highly expressed in the bladder. Also CC expressed in kidney, brain and skeletal muscle. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X93313; CAA63713.1; -; mRNA. DR PIR; S71336; S71336. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR002062; Oxytocn_rcpt. DR InterPro; IPR001817; Vasoprsn_rcpt. DR PANTHER; PTHR19264:SF31; Oxytocn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00665; OXYTOCINR. DR PRINTS; PR00896; VASOPRESSINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 389 Mesotocin receptor. FT /FTId=PRO_0000069882. FT TOPO_DOM 1 50 Extracellular (Potential). FT TRANSMEM 51 71 1 (Potential). FT TOPO_DOM 72 87 Cytoplasmic (Potential). FT TRANSMEM 88 108 2 (Potential). FT TOPO_DOM 109 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT TOPO_DOM 141 159 Cytoplasmic (Potential). FT TRANSMEM 160 180 4 (Potential). FT TOPO_DOM 181 207 Extracellular (Potential). FT TRANSMEM 208 228 5 (Potential). FT TOPO_DOM 229 275 Cytoplasmic (Potential). FT TRANSMEM 276 296 6 (Potential). FT TOPO_DOM 297 308 Extracellular (Potential). FT TRANSMEM 309 329 7 (Potential). FT TOPO_DOM 330 389 Cytoplasmic (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT CARBOHYD 27 27 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT DISULFID 117 192 By similarity. SQ SEQUENCE 389 AA; 44384 MW; D24EBF372EBB6B38 CRC64; MEGLCLNLDC SELPNSSWVN SSMENQNHSS NSTRDPLKRN EEVAKVEVTV LALILFLALA GNICVLLGIY INRHKHSRMY FFMKHLSIAD LVVAIFQVLP QLIWDITFRF YAPDLVCRLV TYLQVVGMFA STYMLLLMSL DRCLAICQPL RSLHRRSDCV YVLFTWILSF LLSTPQTVIF SLTEVGNGVY DCRADFIQPW GPKAYITWIT LAVYIIPVMI LSVCYGLISY KIWQNIRLKT VCESNLRLST SRRATLSRVS SVRLISKAKI RTVKMTFIIV LAYIVCWTPF FFVQMWSVWD PNPPKEASLF IIAMLLGSLN SCCNPWIYML FTGHLFHDLL QSFLCCSARY LKTQQQGSDL SASRKSNSST FVLSRKSSSQ KSITQPSTA // ID V1BR_MOUSE STANDARD; PRT; 421 AA. AC Q9WU02; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 18-APR-2006, entry version 38. DE Vasopressin V1b receptor (V1bR) (AVPR V1b) (Vasopressin V3 receptor) DE (AVPR V3) (Antidiuretic hormone receptor 1b). GN Name=Avpr1b; Synonyms=V1br; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; RX MEDLINE=99280345; PubMed=10343284; DOI=10.1677/jme.0.0220251; RA Ventura M.A., Rene P., de Keyzer Y., Bertagna X., Clauser E.; RT "Gene and cDNA cloning and characterization of the mouse V3/V1b RT pituitary vasopressin receptor."; RL J. Mol. Endocrinol. 22:251-260(1999). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX MEDLINE=20132529; PubMed=10669045; DOI=10.1254/jjp.81.388; RA Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.; RT "Structure and sequence of the mouse V1a and V1b vasopressin receptor RT genes."; RL Jpn. J. Pharmacol. 81:388-392(1999). CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this CC receptor is mediated by G proteins which activate a phosphatidyl- CC inositol-calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF098867; AAD27957.1; -; Genomic_DNA. DR EMBL; AF098866; AAD27957.1; JOINED; Genomic_DNA. DR EMBL; AB030449; BAA89205.1; -; Genomic_DNA. DR UniGene; Mm.89986; -. DR Ensembl; ENSMUSG00000026432; Mus musculus. DR MGI; MGI:1347010; Avpr1b. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001817; Vasoprsn_rcpt. DR InterPro; IPR000628; Vprs_rcpt_V1B. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PRINTS; PR00897; VASOPRSNV1BR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 421 Vasopressin V1b receptor. FT /FTId=PRO_0000070204. FT TOPO_DOM 1 35 Extracellular (Potential). FT TRANSMEM 36 59 1 (Potential). FT TOPO_DOM 60 71 Cytoplasmic (Potential). FT TRANSMEM 72 93 2 (Potential). FT TOPO_DOM 94 108 Extracellular (Potential). FT TRANSMEM 109 130 3 (Potential). FT TOPO_DOM 131 151 Cytoplasmic (Potential). FT TRANSMEM 152 173 4 (Potential). FT TOPO_DOM 174 202 Extracellular (Potential). FT TRANSMEM 203 223 5 (Potential). FT TOPO_DOM 224 280 Cytoplasmic (Potential). FT TRANSMEM 281 300 6 (Potential). FT TOPO_DOM 301 318 Extracellular (Potential). FT TRANSMEM 319 338 7 (Potential). FT TOPO_DOM 339 421 Cytoplasmic (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT DISULFID 107 186 By similarity. SQ SEQUENCE 421 AA; 46539 MW; E867DC0C700F596F CRC64; MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLILG LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE RRGWPKSSSS AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR ACCRGSKPRV HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP AGSLKDLEQV DGEATMETSI S // ID ANR_EISFO STANDARD; PRT; 420 AA. AC Q75W84; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 21-MAR-2006, entry version 16. DE Annetocin receptor. GN Name=anr; OS Eisenia foetida (Common brandling worm) (Common dung-worm). OC Eukaryota; Metazoa; Annelida; Clitellata; Oligochaeta; Haplotaxida; OC Lumbricina; Lumbricidae; Eisenia. OX NCBI_TaxID=6396; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY. RX PubMed=15175002; DOI=10.1042/BJ20040555; RA Kawada T., Kanda A., Minakata H., Matsushima O., Satake H.; RT "Identification of a novel receptor for an invertebrate RT oxytocin/vasopressin superfamily peptide: molecular and functional RT evolution of the oxytocin/vasopressin superfamily."; RL Biochem. J. 382:231-237(2004). CC -!- FUNCTION: Receptor for annetocin. Activation by annetocin may CC induce egg-laying behavior through calcium-dependent signaling. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Nephridia in clitellum region. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB121771; BAD15088.1; -; mRNA. DR GO; GO:0016021; C:integral to membrane; IC. DR GO; GO:0016500; F:protein-hormone receptor activity; IDA. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IC. DR GO; GO:0018991; P:oviposition; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001817; Vasoprsn_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 420 Annetocin receptor. FT /FTId=PRO_0000069172. FT TOPO_DOM 1 54 Extracellular (Potential). FT TRANSMEM 55 75 1 (Potential). FT TOPO_DOM 76 83 Cytoplasmic (Potential). FT TRANSMEM 84 104 2 (Potential). FT TOPO_DOM 105 124 Extracellular (Potential). FT TRANSMEM 125 145 3 (Potential). FT TOPO_DOM 146 166 Cytoplasmic (Potential). FT TRANSMEM 167 187 4 (Potential). FT TOPO_DOM 188 212 Extracellular (Potential). FT TRANSMEM 213 233 5 (Potential). FT TOPO_DOM 234 328 Cytoplasmic (Potential). FT TRANSMEM 329 349 6 (Potential). FT TOPO_DOM 350 360 Extracellular (Potential). FT TRANSMEM 361 381 7 (Potential). FT TOPO_DOM 382 420 Cytoplasmic (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT DISULFID 122 201 By similarity. SQ SEQUENCE 420 AA; 46410 MW; AC6A8B8114BC9275 CRC64; MEMDDDEAIL LDDIYALAST PNQTIVTSSF PQTVSPGFLA RRNEALAMVE VAVQSTILIL TVVGNAAVLA MIVSLSRHKD LGRMYTMIGH LSCADLFVAI FNLLPQLLWD VTHRFRGGRV LCKLVKYVQV VAMYASAYVL MSTAVDRYTA ICHPMRSHTW TSTTAHYLVI GAWVLALVFA VPQLVIFDYV EVVPGSGVYD CVDHFRPRWT LPVYITWFAL AVYVIPLVVL ATIYLRICVV VWKSANRKST PMINVAARTS GATEQPSLDD ASVSFNVADG GGVDLDPSGG GGSLSRHAAQ LSHRQQQQQA NNVVLSRAKT KTVKLTLTVV ISYLVCWAPF FVSHIWSAWD PHAPFEGTEM VITLLLGSLN SCINPWIYLA FSDQLRRKVT QCCPRSWGQR PSTLSHDSTD FRSGSRPTHS // ID DUFFY_BOVIN STANDARD; PRT; 330 AA. AC Q9GLX0; DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 18-APR-2006, entry version 26. DE Duffy antigen/chemokine receptor (CD234 antigen). GN Name=DARC; Synonyms=FY; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Tournamille C., Colin Y.; RT "Bovine DARC gene."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Non-specific receptor for many chemokines (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Duffy CC family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF109158; AAG31021.1; -; Genomic_DNA. DR UniGene; Bt.27077; -. DR InterPro; IPR005384; Duffy_cmk_rcpt. DR PANTHER; PTHR14181; Dufatg/cmkrecept; 1. DR PRINTS; PR01559; DUFFYANTIGEN. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 330 Duffy antigen/chemokine receptor. FT /FTId=PRO_0000152582. FT TOPO_DOM 1 57 Extracellular (Potential). FT TRANSMEM 58 78 1 (Potential). FT TOPO_DOM 79 89 Cytoplasmic (Potential). FT TRANSMEM 90 110 2 (Potential). FT TOPO_DOM 111 123 Extracellular (Potential). FT TRANSMEM 124 147 3 (Potential). FT TOPO_DOM 148 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT TOPO_DOM 182 201 Extracellular (Potential). FT TRANSMEM 202 222 5 (Potential). FT TOPO_DOM 223 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT TOPO_DOM 260 281 Extracellular (Potential). FT TRANSMEM 282 302 7 (Potential). FT TOPO_DOM 303 330 Cytoplasmic (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT CARBOHYD 35 35 N-linked (GlcNAc...) (Potential). FT CARBOHYD 52 52 N-linked (GlcNAc...) (Potential). FT DISULFID 45 270 By similarity. FT DISULFID 123 189 By similarity. SQ SEQUENCE 330 AA; 35473 MW; EB731B87848973EB CRC64; MGNCLYPVAD DNSTKLAIKE DFLIDFPEDY YPDYNETDVE AAAPCHSCSL LNYSSLPFFI LVSILGILAS GTILYALLRP LFRWQLYQDR STLVQLAVGS ALFSIVVPIL ARGLSGALIT SLCHLAHLVA YGSAFAQALL IGYHACLGPR LGAGQVPGLR LGVTVGLWGV AALLSLPVVL GSDTSQGLCT VTFSGEWETL RYIHAAACFA IFVLLPLGLL GTKGLKTVLG RAPCPWVDVL WVWFIFWWPQ GMTLGLDSLV RSKAIVVSTC PAQQALDMLL DVAEALAILH CVATPLLLAW VCYQATHTSP PSLPLPTTQT SHLDTLGSKS // ID AGTR2_MOUSE STANDARD; PRT; 363 AA. AC P35374; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 1. DT 02-MAY-2006, entry version 51. DE Type-2 angiotensin II receptor (AT2). GN Name=Agtr2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c; TISSUE=Fetus; RX MEDLINE=94092107; PubMed=8267573; RA Nakajima M., Mukoyama M., Pratt R.E., Horiuchi M., Dzau V.J.; RT "Cloning of cDNA and analysis of the gene for mouse angiotensin II RT type 2 receptor."; RL Biochem. Biophys. Res. Commun. 197:393-399(1993). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c; RX MEDLINE=94122216; PubMed=8292631; DOI=10.1016/0005-2736(94)90072-8; RA Ichiki T., Herold C.L., Kambayashi Y., Bardhan S., Inagami T.; RT "Cloning of the cDNA and the genomic DNA of the mouse angiotensin II RT type 2 receptor."; RL Biochim. Biophys. Acta 1189:247-250(1994). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96337434; PubMed=8726696; RA Nahmias C., Cazaubon S.M., Sutren M., Masson M., Lazard D., RA Villageois P., Elbaz N., Strosberg A.D.; RT "Molecular and functional characterization of angiotensin II AT2 RT receptor in neuroblastoma N1E-115 cells."; RL Adv. Exp. Med. Biol. 396:167-173(1996). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c; TISSUE=Liver; RX MEDLINE=95378283; PubMed=7650042; DOI=10.1074/jbc.270.34.20225; RA Horiuchi M., Koike G., Yamada T., Mukoyama M., Nakajima M., Dzau V.J.; RT "The growth-dependent expression of angiotensin II type 2 receptor is RT regulated by transcription factors interferon regulatory factor-1 and RT -2."; RL J. Biol. Chem. 270:20225-20230(1995). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Head; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Mammary gland; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP DISULFIDE BONDS. RX PubMed=11444984; DOI=10.1021/bi002805p; RA Heerding J.N., Hines J., Fluharty S.J., Yee D.K.; RT "Identification and function of disulfide bridges in the extracellular RT domains of the angiotensin II type 2 receptor."; RL Biochemistry 40:8369-8377(2001). CC -!- FUNCTION: Receptor for angiotensin II. May have a role in cell CC morphogenesis and related events in growth and development. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Abundant in fetus, lower levels in adult CC brain. CC -!- PTM: Carboxyl-terminal Ser or Thr residues may be phosphorylated. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; S67465; AAB29336.1; -; mRNA. DR EMBL; U04828; AAC52128.1; -; mRNA. DR EMBL; U00766; AAC04933.1; -; mRNA. DR EMBL; L32840; AAB49539.1; ALT_INIT; mRNA. DR EMBL; U11073; AAA82184.1; -; Genomic_DNA. DR EMBL; AK086334; BAC39650.1; -; mRNA. DR EMBL; BC003811; AAH03811.1; -; mRNA. DR PIR; I48261; I48261. DR UniGene; Mm.2679; -. DR HSSP; P34996; 1DDD. DR MGI; MGI:87966; Agtr2. DR GO; GO:0004945; F:angiotensin type II receptor activity; IDA. DR GO; GO:0002033; P:angiotensin mediated vasodilation during re...; IMP. DR GO; GO:0002035; P:brain renin-angiotensin system; IDA. DR InterPro; IPR000248; Angtn2_rcpt. DR InterPro; IPR000147; AT2_rcpt. DR InterPro; IPR001186; BK_rcpt_B1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19264:SF178; AT2_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00636; ANGIOTENSN2R. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphorylation; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 363 Type-2 angiotensin II receptor. FT /FTId=PRO_0000069169. FT TOPO_DOM 1 45 Extracellular (Potential). FT TRANSMEM 46 71 1 (Potential). FT TOPO_DOM 72 80 Cytoplasmic (Potential). FT TRANSMEM 81 102 2 (Potential). FT TOPO_DOM 103 119 Extracellular (Potential). FT TRANSMEM 120 140 3 (Potential). FT TOPO_DOM 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 179 4 (Potential). FT TOPO_DOM 180 208 Extracellular (Potential). FT TRANSMEM 209 234 5 (Potential). FT TOPO_DOM 235 256 Cytoplasmic (Potential). FT TRANSMEM 257 278 6 (Potential). FT TOPO_DOM 279 297 Extracellular (Potential). FT TRANSMEM 298 318 7 (Potential). FT TOPO_DOM 319 363 Cytoplasmic (Potential). FT MOD_RES 354 354 Phosphoserine (by PKC) (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential). FT DISULFID 35 290 FT DISULFID 117 195 SQ SEQUENCE 363 AA; 41374 MW; 6C7D6E3B026D1E80 CRC64; MKDNFSFAAT SRNITSSRPF DNLNATGTNE SAFNCSHKPS DKHLEAIPVL YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLALAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR KGSSLREMDT FVS // ID GPR44_HUMAN STANDARD; PRT; 395 AA. AC Q9Y5Y4; O94765; Q4QRI6; DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot. DT 11-JUL-2001, sequence version 2. DT 18-APR-2006, entry version 45. DE Putative G-protein coupled receptor 44 (Chemoattractant receptor- DE homologous molecule expressed on Th2 cells) (CD294 antigen). GN Name=GPR44; Synonyms=CRTH2, DL1R; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=99156852; PubMed=10036181; DOI=10.1006/geno.1998.5655; RA Marchese A., Sawzdargo M., Nguyen T., Cheng R., Heng H.H., Nowak T., RA Im D.-S., Lynch K.R., George S.R., O'Dowd B.F.; RT "Discovery of three novel orphan G-protein-coupled receptors."; RL Genomics 56:12-21(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Blood; RX MEDLINE=99138803; PubMed=9973380; RA Nagata K., Tanaka K., Ogawa K., Kemmotsu K., Imai T., Yoshie O., RA Abe H., Tada K., Nakamura M., Sugamura K., Takano S.; RT "Selective expression of a novel surface molecule by human Th2 cells RT in vivo."; RL J. Immunol. 162:1278-1286(1999). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Placenta; RA Methner A., Schroeder S.; RT "Tissue expression and chromosomal organization of a novel G protein- RT coupled receptor."; RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta; RA King M.M., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF118265; AAD21055.1; ALT_INIT; Genomic_DNA. DR EMBL; AB008535; BAA74518.1; -; mRNA. DR EMBL; AF144308; AAD34539.1; -; mRNA. DR EMBL; AY507142; AAR92484.1; -; mRNA. DR EMBL; BC096841; AAH96841.1; -; mRNA. DR UniGene; Hs.299567; -. DR Ensembl; ENSG00000183134; Homo sapiens. DR HGNC; HGNC:4502; GPR44. DR MIM; 604837; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0006955; P:immune response; TAS. DR InterPro; IPR000826; Frt_met_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00526; FMETLEUPHER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 395 Putative G-protein coupled receptor 44. FT /FTId=PRO_0000069572. FT TOPO_DOM 1 33 Extracellular (Potential). FT TRANSMEM 34 56 1 (Potential). FT TOPO_DOM 57 67 Cytoplasmic (Potential). FT TRANSMEM 68 89 2 (Potential). FT TOPO_DOM 90 106 Extracellular (Potential). FT TRANSMEM 107 127 3 (Potential). FT TOPO_DOM 128 146 Cytoplasmic (Potential). FT TRANSMEM 147 168 4 (Potential). FT TOPO_DOM 169 210 Extracellular (Potential). FT TRANSMEM 211 231 5 (Potential). FT TOPO_DOM 232 247 Cytoplasmic (Potential). FT TRANSMEM 248 269 6 (Potential). FT TOPO_DOM 270 288 Extracellular (Potential). FT TRANSMEM 289 308 7 (Potential). FT TOPO_DOM 309 395 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 25 25 N-linked (GlcNAc...) (Potential). FT DISULFID 104 182 Potential. FT CONFLICT 375 395 GSCAASPQTGPLNRALSSTSS -> VQLRSVPADGPPEPGA FT EQHLELEPGPRRAALTRESITRVPRFNSISGLLPQ (in FT Ref. 1). SQ SEQUENCE 395 AA; 43240 MW; 9DBBB53B2008C1D1 CRC64; MSANATLKPL CPILEQMSRL QSHSNTSIRY IDHAAVLLHG LASLLGLVEN GVILFVVGCR MRQTVVTTWV LHLALSDLLA SASLPFFTYF LAVGHSWELG TTFCKLHSSI FFLNMFASGF LLSAISLDRC LQVVRPVWAQ NHRTVAAAHK VCLVLWALAV LNTVPYFVFR DTISRLDGRI MCYYNVLLLN PGPDRDATCN SRQAALAVSK FLLAFLVPLA IIASSHAAVS LRLQHRGRRR PGRFVRLVAA VVAAFALCWG PYHVFSLLEA RAHANPGLRP LVWRGLPFVT SLAFFNSVAN PVLYVLTCPD MLRKLRRSLR TVLESVLVDD SELGGAGSSR RRRTSSTARS ASPLALCSRP EEPRGPARLL GWLLGSCAAS PQTGPLNRAL SSTSS // ID PRLHR_BOVIN STANDARD; PRT; 370 AA. AC Q4EW11; DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 30-AUG-2005, sequence version 1. DT 18-APR-2006, entry version 10. DE Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G- DE protein coupled receptor 10). GN Name=PRLHR; Synonyms=GPR10; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Pituitary; RA Feng H., Yuan Z., Xiao S.D., Ying Y., Chun W.Y.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for prolactin-releasing peptide (PrRP). CC Implicated in lactation, regulation of food intake and pain-signal CC processing (By similarity). CC -!- SUBUNIT: Interacts through its C-terminal region with the PDZ CC domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with CC PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1 (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; DQ119288; AAZ09449.1; -; Genomic_DNA. DR UniGene; Bt.31846; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001402; Prolrel_pep_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01018; PRPRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 370 Prolactin-releasing peptide receptor. FT /FTId=PRO_0000069523. FT TOPO_DOM 1 62 Extracellular (Potential). FT TRANSMEM 63 83 1 (Potential). FT TOPO_DOM 84 101 Cytoplasmic (Potential). FT TRANSMEM 102 122 2 (Potential). FT TOPO_DOM 123 126 Extracellular (Potential). FT TRANSMEM 127 147 3 (Potential). FT TOPO_DOM 148 175 Cytoplasmic (Potential). FT TRANSMEM 176 196 4 (Potential). FT TOPO_DOM 197 225 Extracellular (Potential). FT TRANSMEM 226 246 5 (Potential). FT TOPO_DOM 247 276 Cytoplasmic (Potential). FT TRANSMEM 277 297 6 (Potential). FT TOPO_DOM 298 317 Extracellular (Potential). FT TRANSMEM 318 338 7 (Potential). FT TOPO_DOM 339 369 Cytoplasmic (Potential). FT REGION 365 370 Required for interaction with GRIP1, FT GRIP2 and PICK1 (By similarity). FT CARBOHYD 27 27 N-linked (GlcNAc...) (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT DISULFID 134 211 By similarity. SQ SEQUENCE 370 AA; 41226 MW; 5E4580C74236D475 CRC64; MASLPTQGPA APDFFNGLLP ASSSPVNQSS ETVVGNGSAA GPGSQAITPF QSLQLVHQLK GLIVLLYSIV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG NLALSDVLMC TACVPLTLAY AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF TLTTIAVDRY VVLVHPLRRR ISLRFSAYAV LAIWALSAVL ALPAALHTYH VELKPHRVRL CEEFWGSQER QRQLYAWGLL LVTYLLPLLV ILLSYVRVSV NLRNRVVPGC VTQSQADWDR ARRRRTFCLL VVVVVVFAVC WLPLHVFNLL RDLDPHAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKLL LAWPRKIAPH GQSMTVSVVI // ID NPY2R_HUMAN STANDARD; PRT; 381 AA. AC P49146; Q13281; Q13457; Q6AZZ6; Q9UE67; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 18-APR-2006, entry version 47. DE Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor). GN Name=NPY2R; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Hippocampus; RX MEDLINE=96070760; PubMed=7592910; DOI=10.1074/jbc.270.45.26758; RA Gerald C., Walker M.W., Vaysse P.J.-J., He C., Branchek T.A., RA Weinshank R.L.; RT "Expression cloning and pharmacological characterization of a human RT hippocampal neuropeptide Y/peptide YY Y2 receptor subtype."; RL J. Biol. Chem. 270:26758-26761(1995). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RX MEDLINE=96226058; PubMed=8632753; RA Gehlert D.R., Beavers L.S., Johnson D., Gackenheimer S.L., RA Schober D.A., Gadski R.A.; RT "Expression cloning of a human brain neuropeptide Y Y2 receptor."; RL Mol. Pharmacol. 49:224-228(1996). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96032678; PubMed=7559383; DOI=10.1074/jbc.270.39.22661; RA Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M., RA Kodukula K., Kienzle B., Seethala R.; RT "Cloning and functional expression of a cDNA encoding a human type 2 RT neuropeptide Y receptor."; RL J. Biol. Chem. 270:22661-22664(1995). RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96209788; PubMed=8643460; DOI=10.1073/pnas.93.10.4661; RA Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., RA Karbon W.; RT "Cloning and functional expression of cDNAs encoding human and rat RT pancreatic polypeptide receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996). RN [5] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97131518; PubMed=8975716; DOI=10.1006/geno.1996.0642; RA Ammar D.A., Eadie D.M., Wong D.J., Ma Y.-Y., Kolakowski L.F. Jr., RA Yang-Feng T.L., Thompson D.A.; RT "Characterization of the human type 2 neuropeptide Y receptor gene RT (NPY2R) and localization to the chromosome 4q region containing the RT type 1 neuropeptide Y receptor gene."; RL Genomics 38:392-398(1996). RN [6] RP NUCLEOTIDE SEQUENCE. RA Zastawny R.L.; RT "Human neuropeptide Y Y2 receptor gene."; RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank CC order of affinity of this receptor for pancreatic polypeptides is CC PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- CC 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: High levels in amygdala, corpus callosum, CC hippocampus and subthalamic nucleus. Also detectable in caudate CC nucleus, hypothalamus and substantia nigra. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U36269; AAC50281.1; -; mRNA. DR EMBL; U42766; AAB04120.1; -; mRNA. DR EMBL; U32500; AAA93170.1; -; mRNA. DR EMBL; U42389; AAB07760.1; -; mRNA. DR EMBL; U50146; AAC51115.1; -; Genomic_DNA. DR EMBL; U76254; AAD00248.1; -; Genomic_DNA. DR EMBL; AY236540; AAO92062.1; -; Genomic_DNA. DR EMBL; BC075053; AAH75053.2; -; mRNA. DR EMBL; BC075052; AAH75052.2; -; mRNA. DR PIR; I39187; I39187. DR UniGene; Hs.37125; -. DR Ensembl; ENSG00000185149; Homo sapiens. DR HGNC; HGNC:7957; NPY2R. DR MIM; 162642; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005246; F:calcium channel regulator activity; TAS. DR GO; GO:0004983; F:neuropeptide Y receptor activity; TAS. DR GO; GO:0004872; F:receptor activity; TAS. DR GO; GO:0007193; P:G-protein signaling, adenylate cyclase inhi...; TAS. DR GO; GO:0007626; P:locomotory behavior; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001358; NPY2_rcpt. DR InterPro; IPR000611; NPY_rcpt. DR PANTHER; PTHR19264:SF97; NPY2_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01014; NRPEPTIDEY2R. DR PRINTS; PR01012; NRPEPTIDEYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 381 Neuropeptide Y receptor type 2. FT /FTId=PRO_0000069928. FT TOPO_DOM 1 49 Extracellular (Potential). FT TRANSMEM 50 72 1 (Potential). FT TOPO_DOM 73 82 Cytoplasmic (Potential). FT TRANSMEM 83 104 2 (Potential). FT TOPO_DOM 105 124 Extracellular (Potential). FT TRANSMEM 125 146 3 (Potential). FT TOPO_DOM 147 166 Cytoplasmic (Potential). FT TRANSMEM 167 187 4 (Potential). FT TOPO_DOM 188 214 Extracellular (Potential). FT TRANSMEM 215 240 5 (Potential). FT TOPO_DOM 241 268 Cytoplasmic (Potential). FT TRANSMEM 269 291 6 (Potential). FT TOPO_DOM 292 304 Extracellular (Potential). FT TRANSMEM 305 328 7 (Potential). FT TOPO_DOM 329 381 Cytoplasmic (Potential). FT LIPID 342 342 S-palmitoyl cysteine (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT DISULFID 123 203 By similarity. FT CONFLICT 134 134 V -> A (in Ref. 3). FT CONFLICT 172 172 A -> G (in Ref. 4). FT CONFLICT 174 174 G -> R (in Ref. 4). FT CONFLICT 202 202 A -> P (in Ref. 4). FT CONFLICT 209 209 G -> A (in Ref. 4). FT CONFLICT 248 248 N -> S (in Ref. 6). FT CONFLICT 311 311 H -> Y (in Ref. 6). SQ SEQUENCE 381 AA; 42731 MW; 7D018C0169597BC7 CRC64; MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ VVLILAYCSI ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT RIWSKLKNHV SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH SEVSVTFKAK KNLEVRKNSG PNDSFTEATN V // ID CCAPR_DROME STANDARD; PRT; 506 AA. AC Q868T3; Q8ITD2; Q9VBJ8; DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 21-MAR-2006, sequence version 3. DT 04-APR-2006, entry version 20. DE Cardioacceleratory peptide receptor. GN Name=CcapR; ORFNames=CG6111; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION. RC STRAIN=Canton-S; RX MEDLINE=22177201; PubMed=12177421; DOI=10.1073/pnas.162276199; RA Park Y., Kim Y.-J., Adams M.E.; RT "Identification of G protein-coupled receptors for Drosophila PRXamide RT peptides, CCAP, corazonin, and AKH supports a theory of ligand- RT receptor coevolution."; RL Proc. Natl. Acad. Sci. U.S.A. 99:11423-11428(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND RP DEVELOPMENTAL STAGE. RX MEDLINE=22533225; PubMed=12646179; DOI=10.1016/S0006-291X(03)00302-4; RA Cazzamali G., Hauser F., Kobberup S., Williamson M., RA Grimmelikhuijzen C.J.P.; RT "Molecular identification of a Drosophila G protein-coupled receptor RT specific for crustacean cardioactive peptide."; RL Biochem. Biophys. Res. Commun. 303:146-152(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- FUNCTION: Binds to the cardioacceleratory peptide, which is a CC neuropeptide. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: In adults, expressed abundantly in the head CC and very weakly in the body. CC -!- DEVELOPMENTAL STAGE: Expressed in all stages, with abundance in CC embryo and only very weakly in larvae. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: Ref.1 sequence differs from that shown due to intron CC retention. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF522188; AAN10041.1; ALT_SEQ; mRNA. DR EMBL; AY219842; AAO66429.1; -; mRNA. DR EMBL; AE003754; AAF56536.4; -; Genomic_DNA. DR UniGene; Dm.20260; -. DR Ensembl; CG33344; Drosophila melanogaster. DR FlyBase; FBgn0039396; CcapR. DR GO; GO:0005887; C:integral to plasma membrane; NAS. DR GO; GO:0001653; F:peptide receptor activity; IDA. DR GO; GO:0018990; P:ecdysis (sensu Insecta); TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001817; Vasoprsn_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 506 Cardioacceleratory peptide receptor. FT /FTId=PRO_0000069218. FT TOPO_DOM 1 54 Extracellular (Potential). FT TRANSMEM 55 75 1 (Potential). FT TOPO_DOM 76 129 Cytoplasmic (Potential). FT TRANSMEM 130 150 2 (Potential). FT TOPO_DOM 151 164 Extracellular (Potential). FT TRANSMEM 165 185 3 (Potential). FT TOPO_DOM 186 239 Cytoplasmic (Potential). FT TRANSMEM 240 260 4 (Potential). FT TOPO_DOM 261 287 Extracellular (Potential). FT TRANSMEM 288 308 5 (Potential). FT TOPO_DOM 309 353 Cytoplasmic (Potential). FT TRANSMEM 354 374 6 (Potential). FT TOPO_DOM 375 383 Extracellular (Potential). FT TRANSMEM 384 404 7 (Potential). FT TOPO_DOM 405 506 Cytoplasmic (Potential). FT CARBOHYD 35 35 N-linked (GlcNAc...) (Potential). FT CONFLICT 45 45 A -> V (in Ref. 1). FT CONFLICT 494 494 R -> V (in Ref. 1). SQ SEQUENCE 506 AA; 55804 MW; FDFA0BDADF195F76 CRC64; MLHLRLFDSS LYYTLASASE SSGLASSTST ERSFNGTQGA GGVAAGGESL TPTDVAAVNL TYFTPAISHV MLAPTTIATT TASATMVQIQ TTAAPSHDLE TGGNSTSSDP GEFDNLNSFY FYETEQFAVL WILFTVIVLG NSAVLFVMFI NKNRKSRMNY FIKQLALADL CVGLLNVLTD IIWRITISWR AGNLACKAIR FSQVCVTYSS TYVLVAMSID RYDAITHPMN FSKSWKRARH LVAGAWLISA LFSLPILVLY EEKLIQGHPQ CWIELGSPIA WQVYMSLVSA TLFAIPALII SACYAIIVKT IWAKGSIFVP TERAGFGAAP ARRASSRGII PRAKVKTVKM TLTIVFVFII CWSPYIIFDL LQVFGQIPHS QTNIAIATFI QSLAPLNSAA NPLIYCLFSS QVFRTLSRFP PFKWFTCCCK SYRNNSQQNR CHTVGRRLHN SCDSMRTLTT SLTVSRRSTN KTNARVVICE RPTKVVTVPA MSERRGVSLK GNTDIL // ID QRFPR_MOUSE STANDARD; PRT; 433 AA. AC P83861; DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot. DT 10-MAY-2004, sequence version 1. DT 04-APR-2006, entry version 23. DE Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) DE (SP9155) (AQ27). GN Name=Gpr103; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=12714592; DOI=10.1074/jbc.M302945200; RA Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N., RA Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S., RA Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.; RT "Identification and characterization of a novel RF-amide peptide RT ligand for orphan G-protein-coupled receptor SP9155."; RL J. Biol. Chem. 278:27652-27657(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX PubMed=12960173; DOI=10.1074/jbc.M305270200; RA Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y., RA Shintani Y., Hinuma S., Fujino M.; RT "A new peptidic ligand and its receptor regulating adrenal function in RT rats."; RL J. Biol. Chem. 278:46387-46395(2003). CC -!- FUNCTION: Receptor for the orexigenic neuropeptide QRFP. The CC activity of this receptor is mediated by G proteins that modulate CC adenylate cyclase activity and intracellular calcium levels (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed widely in the brain with high levels CC in the cortex and hypothalamus, and moderate levels in the brain CC stem, caudate nucleus, midbrain hippocampus, thalamus, trigeminal CC ganglia and spinal cord. In peripheral tissues, expressed at CC moderate levels in the liver, kidney, pituitary gland and thymus. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB109631; BAC98940.1; -; mRNA. DR UniGene; Mm.330975; -. DR Ensembl; ENSMUSG00000029917; Mus musculus. DR MGI; MGI:2677633; Gpr103. DR GO; GO:0016021; C:integral to membrane; IC. DR GO; GO:0004930; F:G-protein coupled receptor activity; ISS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; ISS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000611; NPY_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01012; NRPEPTIDEYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 433 Orexigenic neuropeptide QRFP receptor. FT /FTId=PRO_0000070098. FT TOPO_DOM 1 46 Extracellular (Potential). FT TRANSMEM 47 67 1 (Potential). FT TOPO_DOM 68 81 Cytoplasmic (Potential). FT TRANSMEM 82 102 2 (Potential). FT TOPO_DOM 103 120 Extracellular (Potential). FT TRANSMEM 121 141 3 (Potential). FT TOPO_DOM 142 162 Cytoplasmic (Potential). FT TRANSMEM 163 183 4 (Potential). FT TOPO_DOM 184 212 Extracellular (Potential). FT TRANSMEM 213 233 5 (Potential). FT TOPO_DOM 234 271 Cytoplasmic (Potential). FT TRANSMEM 272 292 6 (Potential). FT TOPO_DOM 293 313 Extracellular (Potential). FT TRANSMEM 314 334 7 (Potential). FT TOPO_DOM 335 433 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 433 AA; 49245 MW; 014D5AA21BD73055 CRC64; MQALNITAEQ FSRLLSAHNL TREQFIHRYG LRPLVYTPEL PARAKLAFAL AGALIFALAL FGNSLVIYVV TRSKAMRTVT NIFICSLALS DLLIAFFCIP VTMLQNISDK WLGGAFICKM VPFVQSTAVV TEILTMTCIA VERHQGLIHP FKMKWQYTTR RAFTILGVVW LAAIIVGSPM WHVQRLEIKY DFLYEKEHVC CLEEWASPMH QRIYTTFILV ILFLLPLVVM LVLYSKIGYE LWIKKRVGDS SALQTIHGKE MSKIARKKKR AVVMMVTVVA LFAACWAPFH VVHMMVEYSN FEKEYDDVTI KMVFAVAQTI GFFNSICNPF VYAFMNENFK KNFLSAVCYC IVRETFSPGQ KPGNSGISMM QKRAKLSRSQ RPVAEAKGDL FSDANVDVKL CEQPGEKRQL KRQLAFFSSE LSENSTFGSG HEL // ID PKR1_BOVIN STANDARD; PRT; 393 AA. AC Q8SPN2; DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 04-APR-2006, entry version 27. DE Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G- DE protein coupled receptor ZAQ). GN Name=PROKR1; Synonyms=GPR73, PKR1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=22050031; PubMed=12054613; DOI=10.1016/S0006-291X(02)00239-5; RA Masuda Y., Takatsu Y., Terao Y., Kumano S., Ishibashi Y., Suenaga M., RA Abe M., Fukusumi S., Watanabe T., Shintani Y., Yamada T., Hinuma S., RA Inatomi N., Ohtaki T., Onda H., Fujino M.; RT "Isolation and identification of EG-VEGF/prokineticins as cognate RT ligands for two orphan G-protein-coupled receptors."; RL Biochem. Biophys. Res. Commun. 293:396-402(2002). CC -!- FUNCTION: Receptor for prokineticin 1. Exclusively coupled to the CC G(q) subclass of heteromeric G proteins. Activation leads to CC mobilization of calcium, stimulation of phosphoinositide turnover CC and activation of p44/p42 mitogen-activated protein kinase (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY089972; AAM11888.1; -; mRNA. DR UniGene; Bt.11205; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000611; NPY_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01012; NRPEPTIDEYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 393 Prokineticin receptor 1. FT /FTId=PRO_0000070078. FT TOPO_DOM 1 63 Extracellular (Potential). FT TRANSMEM 64 84 1 (Potential). FT TOPO_DOM 85 98 Cytoplasmic (Potential). FT TRANSMEM 99 119 2 (Potential). FT TOPO_DOM 120 145 Extracellular (Potential). FT TRANSMEM 146 166 3 (Potential). FT TOPO_DOM 167 179 Cytoplasmic (Potential). FT TRANSMEM 180 200 4 (Potential). FT TOPO_DOM 201 232 Extracellular (Potential). FT TRANSMEM 233 253 5 (Potential). FT TOPO_DOM 254 282 Cytoplasmic (Potential). FT TRANSMEM 283 303 6 (Potential). FT TOPO_DOM 304 322 Extracellular (Potential). FT TRANSMEM 323 343 7 (Potential). FT TOPO_DOM 344 393 Cytoplasmic (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT DISULFID 137 217 By similarity. SQ SEQUENCE 393 AA; 44603 MW; CF302DD364D8A2CC CRC64; MEITMGVMDE NATNTSTNYF PLLDPLGAQA ASFPFNFSYG DYDMPLDEDE DMTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFIAALARY KKLRNLTNLL IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCASV NYLRTVSLYV STNALLAIAI DRYLAIVHPL RPRMKYQTAT GLIALVWVVS ILVAIPSAYF TTETVLVIVK SQEKIFCGQI WPVDQQIYYK SYFLFIFGIE FVGPVVTMTL CYARISRELW FKAVPGFQTE QIRKRLRCRR KTVLVLMCIL TAYVLCWAPF YGFAIVRDFF PTVFVKEKHY LTAFYVVECI AMSNSMINTV CFVTVKNNTI KYFKKIMLLH WKASYNGSKS SGDLDLKTTG VPATEEVDCI GLK //