ID 5HT1B_FUGRU STANDARD; PRT; 416 AA. AC O42384; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 07-MAR-2006, entry version 40. DE 5-hydroxytryptamine 1A-beta receptor (5-HT-1A-beta) (Serotonin DE receptor 1A-beta) (5-HT1A-beta) (F1B). OS Fugu rubripes (Japanese pufferfish) (Takifugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; OC Tetradontoidea; Tetraodontidae; Takifugu. OX NCBI_TaxID=31033; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Testis; RX MEDLINE=97361762; PubMed=9218723; DOI=10.1016/S0378-1119(97)00064-4; RA Yamaguchi F., Brenner S.; RT "Molecular cloning of 5-hydroxytryptamine (5-HT) type 1 receptor genes RT from the Japanese puffer fish, Fugu rubripes."; RL Gene 191:219-223(1997). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X95937; CAA65176.1; -; Genomic_DNA. DR HSSP; P08913; 1HLL. DR Ensembl; SINFRUG00000129352; Fugu rubripes. DR InterPro; IPR000610; 5HT1A_rcpt. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF103; 5HT1A_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00512; 5HT1ARECEPTR. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 416 5-hydroxytryptamine 1A-beta receptor. FT /FTId=PRO_0000068924. FT TOPO_DOM 1 33 Extracellular (Potential). FT TRANSMEM 34 59 1 (Potential). FT TOPO_DOM 60 70 Cytoplasmic (Potential). FT TRANSMEM 71 95 2 (Potential). FT TOPO_DOM 96 106 Extracellular (Potential). FT TRANSMEM 107 129 3 (Potential). FT TOPO_DOM 130 149 Cytoplasmic (Potential). FT TRANSMEM 150 170 4 (Potential). FT TOPO_DOM 171 193 Extracellular (Potential). FT TRANSMEM 194 219 5 (Potential). FT TOPO_DOM 220 339 Cytoplasmic (Potential). FT TRANSMEM 340 361 6 (Potential). FT TOPO_DOM 362 372 Extracellular (Potential). FT TRANSMEM 373 397 7 (Potential). FT TOPO_DOM 398 416 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT DISULFID 106 189 By similarity. SQ SEQUENCE 416 AA; 47031 MW; 9B4CC415BEC750FE CRC64; MEGTNNTTGW THFDSTSNRT SKSFDEEVKL SYQVVTSFLL GALILCSIFG NACVVAAIAL ERSLQNVANY LIGSLAVTDL MVSVLVLPMA ALYQVLNRWT LGQIPCDIFI SLDMLCCTSS ILHLCVIALD RYWAITEPID YMKKRTPRRA AVLISVTWLV GFSISIPPML IMRSQPSSMA EDRANSKQCK ITQDPWYTIY STFGAFYIPL TLMLVLYGRI FKAARFRIRR TVRKTEKKKV SDTCLALSPA MFHRKTPGDA HGKSWKRSVE PRPLPNVNGA VKHAGEGESL DIIEVQSNSR CNLPLPNTPG TVPLFENRHE KATETKRKIA LARERKTVKT LGIIMGTFIL CWLPFFIVAL VMPFCQESCF MPHWLKDVIN WLGYSNSLLN PIIYAYFNKD FQSAFKKIIK CHFCRA // ID 5HT1D_MOUSE STANDARD; PRT; 374 AA. AC Q61224; Q61615; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 18-APR-2006, entry version 45. DE 5-hydroxytryptamine 1D receptor (5-HT-1D) (Serotonin receptor 1D). GN Name=Htr1d; Synonyms=Gpcr14; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NMRI; TISSUE=Brain; RX MEDLINE=97133356; PubMed=8978753; RA Wurch T., Palmier C., Colpaert F.C., Pauwels P.J.; RT "Sequence and functional analysis of cloned guinea pig and rat RT serotonin 5-HT1D receptors: common pharmacological features within the RT 5-HT1D receptor subfamily."; RL J. Neurochem. 68:410-418(1997). RN [2] RP NUCLEOTIDE SEQUENCE OF 135-306. RC TISSUE=Testis; RX MEDLINE=94116980; PubMed=8288218; RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., RA Copeland N.G., Jenkins N.A.; RT "Identification, chromosomal location, and genome organization of RT mammalian G-protein-coupled receptors."; RL Genomics 18:175-184(1993). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X94908; CAA64395.1; -; Genomic_DNA. DR EMBL; L20335; AAA16847.1; -; mRNA. DR PIR; F48909; F48909. DR UniGene; Mm.40573; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSMUSG00000036956; Mus musculus. DR MGI; MGI:96276; Htr1d. DR InterPro; IPR000505; 5HT1D_rcpt. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF128; 5HT1D_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00514; 5HT1DRECEPTR. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 374 5-hydroxytryptamine 1D receptor. FT /FTId=PRO_0000068928. FT TOPO_DOM 1 35 Extracellular (Potential). FT TRANSMEM 36 59 1 (Potential). FT TOPO_DOM 60 72 Cytoplasmic (Potential). FT TRANSMEM 73 95 2 (Potential). FT TOPO_DOM 96 105 Extracellular (Potential). FT TRANSMEM 106 131 3 (Potential). FT TOPO_DOM 132 151 Cytoplasmic (Potential). FT TRANSMEM 152 173 4 (Potential). FT TOPO_DOM 174 191 Extracellular (Potential). FT TRANSMEM 192 215 5 (Potential). FT TOPO_DOM 216 299 Cytoplasmic (Potential). FT TRANSMEM 300 323 6 (Potential). FT TOPO_DOM 324 332 Extracellular (Potential). FT TRANSMEM 333 357 7 (Potential). FT TOPO_DOM 358 374 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT DISULFID 108 185 By similarity. SQ SEQUENCE 374 AA; 41540 MW; 1FC6ABF901785D88 CRC64; MSLPNQSLEG LPQEASNRSL NATGAWDPEV LQALRISLVV VLSVITLATV LSNAFVLTTI LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT WNFGQILCDI WVSSDITCCT ASILHLCVIA LDRYWAITDA LEYSKRRTAG HAAAMIAAVW IISICISIPP LFWRQATAHE EMSDCLVNTS QISYTIYSTC GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ LITGSAGSSL CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP VIYTVFNEDF RQAFQKVVHF RKAS // ID 5HT1B_CANFA STANDARD; PRT; 389 AA. AC P79250; Q6VVV0; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 12-APR-2005, sequence version 2. DT 02-MAY-2006, entry version 40. DE 5-hydroxytryptamine 1B receptor (5-HT-1B) (Serotonin receptor 1B) (5- DE HT1B) (5-HTR1B) (5-HT1D subtype beta). GN Name=HTR1B; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=14729271; DOI=10.1016/j.gene.2003.10.028; RA van den Berg L., Imholz S., Versteeg S.A., Leegwater P.A.J., RA Zijlstra C., Bosma A.A., van Oost B.A.; RT "Isolation and characterization of the canine serotonin receptor 1B RT gene (htr1B)."; RL Gene 326:131-139(2004). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Beagle; RX PubMed=15353848; DOI=10.1292/jvms.66.965; RA Masuda K., Hashizume C., Ogata N., Kikusui T., Takeuchi Y., Mori Y.; RT "Sequencing of canine 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, 2C RT genes and identification of polymorphisms in the 5-HTR1B gene."; RL J. Vet. Med. Sci. 66:965-972(2004). RN [3] RP NUCLEOTIDE SEQUENCE. RX PubMed=15220384; DOI=10.1093/jhered/esh033; RA Kukekova A.V., Trut L.N., Oskina I.N., Kharlamova A.V., RA Shikhevich S.G., Kirkness E.F., Aguirre G.D., Acland G.M.; RT "A marker set for construction of a genetic map of the silver fox RT (Vulpes vulpes)."; RL J. Hered. 95:185-194(2004). RN [4] RP NUCLEOTIDE SEQUENCE OF 192-352. RC STRAIN=Alsatian, and Beagle; TISSUE=Artery; RX MEDLINE=96296365; PubMed=8763409; DOI=10.1016/0008-6363(96)00014-4; RA Sgard F., Faure C., Graham D.; RT "Evidence for 5-HT1D beta but not 5-HT1D alpha receptor subtype RT expression in canine large coronary arteries and saphenous vein."; RL Cardiovasc. Res. 31:793-799(1996). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY323909; AAQ89935.1; -; Genomic_DNA. DR EMBL; AB193090; BAD60920.1; -; mRNA. DR EMBL; AY204572; AAP12469.1; -; Genomic_DNA. DR EMBL; S82461; AAB37488.2; -; mRNA. DR UniGene; Cfa.3604; -. DR InterPro; IPR002147; 5HT1B_rcpt. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00513; 5HT1BRECEPTR. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 389 5-hydroxytryptamine 1B receptor. FT /FTId=PRO_0000068910. FT TOPO_DOM 1 50 Extracellular (Potential). FT TRANSMEM 51 74 1 (Potential). FT TOPO_DOM 75 85 Cytoplasmic (Potential). FT TRANSMEM 86 112 2 (Potential). FT TOPO_DOM 113 122 Extracellular (Potential). FT TRANSMEM 123 144 3 (Potential). FT TOPO_DOM 145 166 Cytoplasmic (Potential). FT TRANSMEM 167 186 4 (Potential). FT TOPO_DOM 187 207 Extracellular (Potential). FT TRANSMEM 208 227 5 (Potential). FT TOPO_DOM 228 314 Cytoplasmic (Potential). FT TRANSMEM 315 335 6 (Potential). FT TOPO_DOM 336 349 Extracellular (Potential). FT TRANSMEM 350 372 7 (Potential). FT TOPO_DOM 373 389 Cytoplasmic (Potential). FT LIPID 387 387 S-palmitoyl cysteine (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT DISULFID 121 198 By similarity. SQ SEQUENCE 389 AA; 42930 MW; 4CCB4CCB5792936D CRC64; MEAAGAPCAP PPPAGSQTGA PPANLSSAPH NCSAEGYIYQ DSVALPWKVL LVILLALITL ATTLSNAFVI ATVYRTRKLH TPANYLIASL AVTDLLVSIL VMPISTMYTV TGRWTLGQVV CDLWLSSDIT CCTASILHLC VIALDRYWAI TDAVEYSAKR TPKRAAVMIA LVWVFSISIS LPPFFWRQAK AEEEVSDCVV NTDHILYTVY STVGAFYFPT LLLIALYGRI YVEARSRILK QTPNRTGKRL TRAQLITDSP GSTSSVTSVN SRAPDVPSES GSPVYVNQVK VRVSDALLEK KKLMAARERK ATKTLGIILG AFIVCWLPFF IISLVMPICK DACWFHLAIF DFFTWLGYLN SLINPIIYTM SNEDFKQAFH KLIRFKCAG // ID 5HT1E_HUMAN STANDARD; PRT; 365 AA. AC P28566; Q9P1Y1; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-1992, sequence version 1. DT 18-APR-2006, entry version 61. DE 5-hydroxytryptamine 1E receptor (5-HT-1E) (Serotonin receptor 1E) (5- DE HT1E) (S31). GN Name=HTR1E; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RX MEDLINE=92302274; PubMed=1608964; RA McAllister G., Charlesworth A., Snodin C., Beer M.S., Noble A.J., RA Middlemiss D.N., Iversen L.L., Whiting P.; RT "Molecular cloning of a serotonin receptor from human brain (5HT1E): a RT fifth 5HT1-like subtype."; RL Proc. Natl. Acad. Sci. U.S.A. 89:5517-5521(1992). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92128546; PubMed=1733778; DOI=10.1016/0014-5793(92)80379-U; RA Levy F.O., Gudermann T., Birnbaumer M., Kaumann A.J., Birnbaumer L.; RT "Molecular cloning of a human gene (S31) encoding a novel serotonin RT receptor mediating inhibition of adenylyl cyclase."; RL FEBS Lett. 296:201-206(1992). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92382553; PubMed=1513320; RA Zgombick J.M., Schechter L.E., Macchi M., Hartig P.R., Branchek T.A., RA Weinshank R.L.; RT "Human gene S31 encodes the pharmacologically defined serotonin 5- RT hydroxytryptamine1E receptor."; RL Mol. Pharmacol. 42:180-185(1992). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-363. RA Kitano T., Kobayakawa H., Saitou N.; RT "Silver project."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. RN [8] RP VARIANT PHE-262. RX MEDLINE=99318093; PubMed=10391209; DOI=10.1038/10290; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [9] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M91467; AAA58353.1; -; mRNA. DR EMBL; Z11166; CAA77558.1; -; Genomic_DNA. DR EMBL; M92826; AAA58355.1; -; Genomic_DNA. DR EMBL; AF498980; AAM21127.1; -; mRNA. DR EMBL; AL157777; CAC10582.1; -; Genomic_DNA. DR EMBL; BC069751; AAH69751.1; -; mRNA. DR EMBL; AB041373; BAA94458.1; -; Genomic_DNA. DR PIR; S20579; A45260. DR UniGene; Hs.1611; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSG00000168830; Homo sapiens. DR HGNC; HGNC:5291; HTR1E. DR MIM; 182132; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR000450; 5HT1F_rcpt. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00515; 5HT1FRECEPTR. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 365 5-hydroxytryptamine 1E receptor. FT /FTId=PRO_0000068933. FT TOPO_DOM 1 22 Extracellular (Potential). FT TRANSMEM 23 47 1 (Potential). FT TOPO_DOM 48 59 Cytoplasmic (Potential). FT TRANSMEM 60 81 2 (Potential). FT TOPO_DOM 82 96 Extracellular (Potential). FT TRANSMEM 97 118 3 (Potential). FT TOPO_DOM 119 138 Cytoplasmic (Potential). FT TRANSMEM 139 159 4 (Potential). FT TOPO_DOM 160 179 Extracellular (Potential). FT TRANSMEM 180 201 5 (Potential). FT TOPO_DOM 202 291 Cytoplasmic (Potential). FT TRANSMEM 292 314 6 (Potential). FT TOPO_DOM 315 324 Extracellular (Potential). FT TRANSMEM 325 347 7 (Potential). FT TOPO_DOM 348 365 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT DISULFID 95 173 By similarity. FT VARIANT 208 208 A -> T (in dbSNP:3828741). FT /FTId=VAR_022061. FT VARIANT 262 262 S -> F (in dbSNP:6303). FT /FTId=VAR_014165. SQ SEQUENCE 365 AA; 41682 MW; 4C31DD783A3F7483 CRC64; MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT KKLHQPANYL ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS VDMTCCTCSI LHLCVIALDR YWAITNAIEY ARKRTAKRAA LMILTVWTIS IFISMPPLFW RSHRRLSPPP SQCTIQHDHV IYTIYSTLGA FYIPLTLILI LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ TFCVSDFSTS DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED FKLAFKKLIR CREHT // ID 5HTR_HELVI STANDARD; PRT; 466 AA. AC Q25190; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 07-MAR-2006, entry version 33. DE 5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor). OS Heliothis virescens (Noctuid moth) (Owlet moth). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; OC Noctuidae; Heliothinae; Heliothis. OX NCBI_TaxID=7102; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Antenna; RX MEDLINE=97166608; PubMed=9014328; DOI=10.1016/S0965-1748(96)00031-8; RA von Nickisch-Rosenegk E., Krieger J., Kubick S., Laage R., Strobel J., RA Strotmann J., Breer H.; RT "Cloning of biogenic amine receptors from moths (Bombyx mori and RT Heliothis virescens)."; RL Insect Biochem. Mol. Biol. 26:817-827(1996). CC -!- FUNCTION: This is a receptor for 5-hydroxytryptamine (serotonin), CC a biogenic hormone that function as a neurotransmitter, a hormone, CC and a mitogen (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X95605; CAA64863.1; -; mRNA. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 466 5-hydroxytryptamine receptor. FT /FTId=PRO_0000068986. FT TOPO_DOM 1 66 Extracellular (Potential). FT TRANSMEM 67 89 1 (Potential). FT TOPO_DOM 90 99 Cytoplasmic (Potential). FT TRANSMEM 100 121 2 (Potential). FT TOPO_DOM 122 136 Extracellular (Potential). FT TRANSMEM 137 158 3 (Potential). FT TOPO_DOM 159 177 Cytoplasmic (Potential). FT TRANSMEM 178 200 4 (Potential). FT TOPO_DOM 201 228 Extracellular (Potential). FT TRANSMEM 229 250 5 (Potential). FT TOPO_DOM 251 386 Cytoplasmic (Potential). FT TRANSMEM 387 410 6 (Potential). FT TOPO_DOM 411 419 Extracellular (Potential). FT TRANSMEM 420 442 7 (Potential). FT TOPO_DOM 443 466 Cytoplasmic (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 41 41 N-linked (GlcNAc...) (Potential). FT CARBOHYD 45 45 N-linked (GlcNAc...) (Potential). FT CARBOHYD 50 50 N-linked (GlcNAc...) (Potential). FT DISULFID 135 215 By similarity. SQ SEQUENCE 466 AA; 52094 MW; AD29A38EC37106EB CRC64; MNASRLPGFN DTSQDQPYPT SSEWFDGSNC SWVDAVSWGC NVTINGTSTN ATSTDVTSFV LMAVTSVVLA LIILATIVGN VFVIAAIIIE RNLQNVANYL VASLAVADLM VACLVMPLGA VYEVSQGWIL GPELCDMWTS SDVLCSSASI LHLVAIATDR YWAVTDVDYI HIRNEKRIFT MIVLVWGAAL VVSLAPQLGW KDPDYLARIT QQQKCLVSQD LAYQIFATMS TFYVPLAVIL ILYWKIFQTA RRRIRRRRDP PPPRPTSADG ATPSGRPVQS ARDRRFVKKR FLNLKKCNQR TRAETLAAAL LLTEGQSTST VDTLDEEPRT TAFTINEKVP PSVSPEKSSS TVTNGSKPER AIVPAPTHRE KKESLEAKRE RKAAKTLAII TGAFVFCWLP FFIMALVMPI CQTCVISDYL ASFFLWLGYF NSTLNPVIYT IFSPDFRQAF ARILFGTHRR RRYKKF // ID 5HTR_BOMMO STANDARD; PRT; 446 AA. AC Q17239; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 21-MAR-2006, entry version 34. DE 5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor). OS Bombyx mori (Silk moth). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; OC Bombycidae; Bombyx. OX NCBI_TaxID=7091; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Antenna; RX MEDLINE=97166608; PubMed=9014328; DOI=10.1016/S0965-1748(96)00031-8; RA von Nickisch-Rosenegk E., Krieger J., Kubick S., Laage R., Strobel J., RA Strotmann J., Breer H.; RT "Cloning of biogenic amine receptors from moths (Bombyx mori and RT Heliothis virescens)."; RL Insect Biochem. Mol. Biol. 26:817-827(1996). CC -!- FUNCTION: This is a receptor for 5-hydroxytryptamine (serotonin), CC a biogenic hormone that function as a neurotransmitter, a hormone, CC and a mitogen (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X95604; CAA64862.1; -; mRNA. DR HSSP; P08913; 1HLL. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 446 5-hydroxytryptamine receptor. FT /FTId=PRO_0000068985. FT TOPO_DOM 1 65 Extracellular (Potential). FT TRANSMEM 66 88 1 (Potential). FT TOPO_DOM 89 98 Cytoplasmic (Potential). FT TRANSMEM 99 120 2 (Potential). FT TOPO_DOM 121 135 Extracellular (Potential). FT TRANSMEM 136 157 3 (Potential). FT TOPO_DOM 158 176 Cytoplasmic (Potential). FT TRANSMEM 177 199 4 (Potential). FT TOPO_DOM 200 227 Extracellular (Potential). FT TRANSMEM 228 249 5 (Potential). FT TOPO_DOM 250 367 Cytoplasmic (Potential). FT TRANSMEM 368 391 6 (Potential). FT TOPO_DOM 392 399 Extracellular (Potential). FT TRANSMEM 400 422 7 (Potential). FT TOPO_DOM 423 446 Cytoplasmic (Potential). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT CARBOHYD 27 27 N-linked (GlcNAc...) (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CARBOHYD 42 42 N-linked (GlcNAc...) (Potential). FT DISULFID 134 214 By similarity. SQ SEQUENCE 446 AA; 48599 MW; 85D4E52C63726AA4 CRC64; MEGAEGQEEL DWEALYLRLP LQNCSWNSTG WEPNWNVTVV PNTTWWQASA PFDTPAALVR AAAKAVVLGL LILATVVGNV FVIAAILLER HLRSAANNLI LSLAVADLLV ACLVMPLGAV YEVVQRWTLG PELCDMWTSG DVLCCTASIL HLVAIALDRY WAVTNIDYIH ASTAKRVGMM IACVWTVSFF VCIAQLLGWK DPDWNQRVSE DLRCVVSQDV GYQIFATASS FYVPVLIILI LYWRIYQTAR KRIRRRRGAT ARGGVGPPPV PAGGALVAGG GSGGIAAAVV AVIGRPLPTI SETTTTGFTN VSSNNTSPEK QSCANGLEAD PPTTGYGAVA AAYYPSLVRR KPKEAADSKR ERKAAKTLAI ITGAFVACWL PFFVLAILVP TCDCEVSPVL TSLSLWLGYF NSTLNPVIYT VFSPEFRHAF QRLLCGRRVR RRRAPQ // ID 5HT5A_MOUSE STANDARD; PRT; 357 AA. AC P30966; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 18-APR-2006, entry version 47. DE 5-hydroxytryptamine 5A receptor (5-HT-5A) (Serotonin receptor 5A) (5- DE HT-5). GN Name=Htr5a; Synonyms=5ht5a; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Brain; RX MEDLINE=93099851; PubMed=1464308; RA Plassat J.-L., Boschert U., Amlaiky N., Hen R.; RT "The mouse 5HT5 receptor reveals a remarkable heterogeneity within the RT 5HT1D receptor family."; RL EMBO J. 11:4779-4786(1992). RN [2] RP CHARACTERIZATION. RC TISSUE=Brain; RX MEDLINE=93196607; PubMed=8450829; RA Matthes H., Boschert U., Amlaiky N., Grailhe R., Plassat J.-L., RA Muscatelli F., Mattei M.-G., Hen R.; RT "Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors RT define a new family of serotonin receptors: cloning, functional RT expression, and chromosomal localization."; RL Mol. Pharmacol. 43:313-319(1993). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed predominantly in the central nervous CC system; in the cerebral cortex, hippocampus, habenula, olfactory CC bulb and granular layer of the cerebellum. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Z18278; CAA79155.1; -; Genomic_DNA. DR UniGene; Mm.4835; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSMUSG00000039106; Mus musculus. DR MGI; MGI:96283; Htr5a. DR InterPro; IPR001397; 5HT5A_rcpt. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00518; 5HT5ARECEPTR. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 357 5-hydroxytryptamine 5A receptor. FT /FTId=PRO_0000068970. FT TOPO_DOM 1 40 Extracellular (Potential). FT TRANSMEM 41 63 1 (Potential). FT TOPO_DOM 64 78 Cytoplasmic (Potential). FT TRANSMEM 79 99 2 (Potential). FT TOPO_DOM 100 115 Extracellular (Potential). FT TRANSMEM 116 137 3 (Potential). FT TOPO_DOM 138 158 Cytoplasmic (Potential). FT TRANSMEM 159 181 4 (Potential). FT TOPO_DOM 182 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT TOPO_DOM 220 282 Cytoplasmic (Potential). FT TRANSMEM 283 303 6 (Potential). FT TOPO_DOM 304 320 Extracellular (Potential). FT TRANSMEM 321 341 7 (Potential). FT TOPO_DOM 342 357 Cytoplasmic (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT DISULFID 120 192 By similarity. SQ SEQUENCE 357 AA; 40805 MW; 5F5D856AC477BFAC CRC64; MDLPVNLTSF SLSTPSSLEP NRSLDTEVLR PSRPFLSAFR VLVLTLLGFL AAATFTWNLL VLATILKVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHLEYT LRTRKRVSNV MILLTWALST VISLAPLLFG WGETYSEPSE ECQVSREPSY TVFSTVGAFY LPLWLVLFVY WKIYRAAKFR MGSRKTNSVS PVPEAVEVKN ATQHPQMVFT ARHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP FFVTELISPL CSWDVPAIWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK VFFSKQQ // ID OAR1_LOCMI STANDARD; PRT; 484 AA. AC Q25321; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 07-MAR-2006, entry version 41. DE Tyramine receptor 1 (Tyr-Loc1). GN Name=GCR1; OS Locusta migratoria (Migratory locust). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Orthopteroidea; Orthoptera; Caelifera; Acridomorpha; OC Acridoidea; Acrididae; Oedipodinae; Locusta. OX NCBI_TaxID=7004; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RC TISSUE=Neuron; RX MEDLINE=95279966; PubMed=7760020; RA Vanden Broeck J.J.M., Vulsteke V., Huybrechts R., de Loof A.; RT "Characterization of a cloned locust tyramine receptor cDNA by RT functional expression in permanently transformed Drosophila S2 RT cells."; RL J. Neurochem. 64:2387-2395(1995). CC -!- FUNCTION: G-protein coupled receptor for tyramine, a known CC neurotransmitter and neuromodulator and direct precursor of CC octopamine. The rank order of potency for agonists of this CC receptor is tyramine > naphazoline > tolazoline > DL-octopamine > CC dopamine > epinephrine > 5-hydroxytryptamine. For antagonists, the CC rank order is yohimbine > chlorpromazine > mianserin > CC phentolamine > metoclopramide. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Present mainly in the central nervous system, CC especially in the supra- and suboesophageal, thoracic and CC abdominal ganglia. Not found in the distal part of optic lobes. CC -!- DEVELOPMENTAL STAGE: Expressed in the nervous system by the first CC larval stage. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X69520; CAA49268.1; -; mRNA. DR PIR; S58868; S58868. DR HSSP; P08913; 1HLL. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR002002; Octopmn_rcpt. DR PANTHER; PTHR19266:SF124; Octopmn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00664; OCTOPAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 484 Tyramine receptor 1. FT /FTId=PRO_0000069954. FT TOPO_DOM 1 54 Extracellular (Potential). FT TRANSMEM 55 77 1 (Potential). FT TOPO_DOM 78 87 Cytoplasmic (Potential). FT TRANSMEM 88 109 2 (Potential). FT TOPO_DOM 110 126 Extracellular (Potential). FT TRANSMEM 127 147 3 (Potential). FT TOPO_DOM 148 167 Cytoplasmic (Potential). FT TRANSMEM 168 190 4 (Potential). FT TOPO_DOM 191 215 Extracellular (Potential). FT TRANSMEM 216 237 5 (Potential). FT TOPO_DOM 238 411 Cytoplasmic (Potential). FT TRANSMEM 412 433 6 (Potential). FT TOPO_DOM 434 448 Extracellular (Potential). FT TRANSMEM 449 470 7 (Potential). FT TOPO_DOM 471 484 Cytoplasmic (Potential). FT COMPBIAS 286 292 Poly-Pro. FT COMPBIAS 294 307 Arg/Lys-rich (basic). FT COMPBIAS 348 360 Poly-Thr. FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 198 198 N-linked (GlcNAc...) (Potential). FT DISULFID 124 203 By similarity. SQ SEQUENCE 484 AA; 53531 MW; 4484FBC85A810619 CRC64; MVRVELQAAS LMNGSSAAEE PQDALVGGDA CGGRRPPSVL GVRLAVPEWE VAVTAVSLSL IILITIVGNV LVVLSVFTYK PLRIVQNFFI VSLAVADLTV AVLVMPFNVA YSLIQRWVFG IVVCKMWLTC DVLCCTASIL NLCAIALDRY WAITDPINYA QKRTLRRVLA MIAGVWLLSG VISSPPLIGW NDWPMEFNDT TPCQLTEEQG YVIYSSLGSF FIPLFIMTIV YVEIFIATKR RLRERAKASK LNSAMKQQMA AQAVPSSVPS HDQESVSSET NHNELPPPPA PPSKEKRRKT KKKSKKKEQA AEEGRFLAPA MVAEDSVTDN SVSVGPVARN HLAEDGYTCT TTTTTTTTTT AVTDSPRSRT ASQKGSTAPP TPVQPKSIPV YQFIEEKQRI SLSKERRAAR TLGIIMGVFV VCWLPFFLMY VIVPFCNPSC KPSPKLVNFI TWLGYINSAL NPIIYTIFNL DFRRAFKKLL HFKT // ID OAR_DROME STANDARD; PRT; 601 AA. AC P22270; Q95YF4; Q9VNW3; DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2000, sequence version 2. DT 04-APR-2006, entry version 64. DE Tyramine/octopamine receptor precursor (Tyr/Oct-Dro). GN Name=TyrR; Synonyms=OcR, OctyR99AB, TYR; ORFNames=CG7485; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Oregon-R; RX MEDLINE=90198291; PubMed=2156539; DOI=10.1016/0896-6273(90)90047-J; RA Arakawa S., Gocayne J.D., McCombie W.R., Urquhart D.A., Hall L.M., RA Fraser C.M., Venter J.C.; RT "Cloning, localization, and permanent expression of a Drosophila RT octopamine receptor."; RL Neuron 4:343-354(1990). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Oregon-R; TISSUE=Head; RX MEDLINE=91006061; PubMed=2170118; RA Saudou F., Amlaiky N., Plassat J.-L., Borelli E., Hen R.; RT "Cloning and characterization of a Drosophila tyramine receptor."; RL EMBO J. 9:3611-3617(1990). RN [3] RP NUCLEOTIDE SEQUENCE, AND FUNCTION. RX MEDLINE=20179681; PubMed=10713442; DOI=10.1016/S0378-1119(99)00569-7; RA Kutsukake M., Komatsu A., Yamamoto D., Chigusa S.I.; RT "A tyramine receptor gene mutation causes a defective olfactory RT behavior in Drosophila melanogaster."; RL Gene 245:31-42(2000). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [5] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- FUNCTION: Receptor for both octopamine and tyramine, invertebrate CC neurotransmitters, and neuromodulators. The activity of this CC receptor is mediated by G proteins which activate adenylyl CC cyclase. The rank order of potency for agonists is tyramine > CC octopamine > dopamine > epinephrine > norepinephrine > serotonin > CC histamine. For antagonists, the rank order is yohimbine > CC chlorpromazine > phentolamine > mianserine > cyproheptadine > CC dihydroergotamine > clonidine > synephrine. Tyramine has a CC functional role in the olfactory system as a neurotransmitter or a CC neuromodulator. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Preferentially expressed in Drosophila heads. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M60789; AAA28731.1; -; mRNA. DR EMBL; X54794; CAA38565.1; -; mRNA. DR EMBL; AB073914; BAB71788.1; -; mRNA. DR EMBL; AE003596; AAF51802.1; -; Genomic_DNA. DR PIR; JH0170; JH0170. DR PIR; S12004; S12004. DR UniGene; Dm.3507; -. DR HSSP; P08913; 1HLL. DR Ensembl; CG7485; Drosophila melanogaster. DR FlyBase; FBgn0004514; TyrR. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-017815-MONOMER; -. DR GO; GO:0007211; P:octopamine/tyramine signaling pathway; IMP. DR GO; GO:0007608; P:sensory perception of smell; IMP. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR002002; Octopmn_rcpt. DR PANTHER; PTHR19266:SF124; Octopmn_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00664; OCTOPAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Signal; Transducer; Transmembrane. FT SIGNAL 1 26 Potential. FT CHAIN 27 601 Tyramine/octopamine receptor. FT /FTId=PRO_0000012737. FT TOPO_DOM 27 112 Extracellular (Potential). FT TRANSMEM 113 135 1 (Potential). FT TOPO_DOM 136 145 Cytoplasmic (Potential). FT TRANSMEM 146 167 2 (Potential). FT TOPO_DOM 168 184 Extracellular (Potential). FT TRANSMEM 185 205 3 (Potential). FT TOPO_DOM 206 225 Cytoplasmic (Potential). FT TRANSMEM 226 248 4 (Potential). FT TOPO_DOM 249 273 Extracellular (Potential). FT TRANSMEM 274 295 5 (Potential). FT TOPO_DOM 296 530 Cytoplasmic (Potential). FT TRANSMEM 531 552 6 (Potential). FT TOPO_DOM 553 566 Extracellular (Potential). FT TRANSMEM 567 588 7 (Potential). FT TOPO_DOM 589 601 Cytoplasmic (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 57 57 N-linked (GlcNAc...) (Potential). FT DISULFID 182 261 By similarity. FT CONFLICT 34 34 S -> N (in Ref. 1 and 3). SQ SEQUENCE 601 AA; 64674 MW; 7E7581A11674B4C9 CRC64; MPSADQILFV NVTTTVAAAA LTAAAAVSTT KSGSGNAARG YTDSDDDAGM GTEAVANISG SLVEGLTTVT AALSTAQADK DSAGECEGAV EELHASILGL QLAVPEWEAL LTALVLSVII VLTIIGNILV ILSVFTYKPL RIVQNFFIVS LAVADLTVAL LVLPFNVAYS ILGRWEFGIH LCKLWLTCDV LCCTSSILNL CAIALDRYWA ITDPINYAQK RTVGRVLLLI SGVWLLSLLI SSPPLIGWND WPDEFTSATP CELTSQRGYV IYSSLGSFFI PLAIMTIVYI EIFVATRRRL RERARANKLN TIALKSTELE PMANSSPVAA SNSGSKSRLL ASWLCCGRDR AQFATPMIQN DQESISSETH QPQDSSKAGP HGNSDPQQQH VVVLVKKSRR AKTKDSIKHG KTRGGRKSQS SSTCEPHGEQ QLLPAGGDGG SCQPGGGHSG GGKSDAEIST ESGSDPKGCI QVCVTQADEQ TSLKLTPPQS STGVAAVSVT PLQKKTSGVN QFIEEKQKIS LSKERRAART LGIIMGVFVI CWLPFFLMYV ILPFCQTCCP TNKFKNFITW LGYINSGLNP VIYTIFNLDY RRAFKRLLGL N // ID ADA2C_BRARE STANDARD; PRT; 432 AA. AC Q90WY6; DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 04-APR-2006, entry version 27. DE Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C DE adrenoreceptor) (Alpha(2C)AR). GN Name=adra2c; OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12949138; DOI=10.1093/molbev/msg224; RA Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., RA Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.; RT "Identification of duplicated fourth alpha2-adrenergic receptor RT subtype by cloning and mapping of five receptor genes in zebrafish."; RL Mol. Biol. Evol. 21:14-28(2004). RN [2] RP FUNCTION, AND 3D-STRUCTURE MODELING. RX PubMed=15655522; DOI=10.1038/sj.bjp.0706057; RA Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., RA Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.; RT "Conserved structural, pharmacological and functional properties among RT the three human and five zebrafish alpha2-adrenoceptors."; RL Br. J. Pharmacol. 144:165-177(2005). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. The order of potency for this receptor is CC dexmedetomidine > norepinephrine > epinephrine. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY048969; AAL07508.1; -; Genomic_DNA. DR UniGene; Dr.30876; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSDARG00000015704; Danio rerio. DR ZFIN; ZDB-GENE-021010-3; adra2c. DR GO; GO:0005887; C:integral to plasma membrane; IC. DR GO; GO:0004938; F:alpha2-adrenergic receptor activity; IDA. DR GO; GO:0007194; P:negative regulation of adenylate cyclase ac...; IDA. DR InterPro; IPR000735; Adren_rcpt_A2C. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00560; ADRENRGCA2CR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 432 Alpha-2C adrenergic receptor. FT /FTId=PRO_0000069108. FT TOPO_DOM 1 35 Extracellular (Potential). FT TRANSMEM 36 60 1 (Potential). FT TOPO_DOM 61 72 Cytoplasmic (Potential). FT TRANSMEM 73 98 2 (Potential). FT TOPO_DOM 99 108 Extracellular (Potential). FT TRANSMEM 109 131 3 (Potential). FT TOPO_DOM 132 152 Cytoplasmic (Potential). FT TRANSMEM 153 175 4 (Potential). FT TOPO_DOM 176 191 Extracellular (Potential). FT TRANSMEM 192 215 5 (Potential). FT TOPO_DOM 216 351 Cytoplasmic (Potential). FT TRANSMEM 352 379 6 (Potential). FT TOPO_DOM 380 392 Extracellular (Potential). FT TRANSMEM 393 413 7 (Potential). FT TOPO_DOM 414 432 Cytoplasmic (Potential). FT COMPBIAS 281 331 Ser-rich. FT SITE 115 115 Implicated in ligand binding (By FT similarity). FT SITE 198 198 Implicated in catechol agonist binding FT and receptor activation (By similarity). FT SITE 202 202 Implicated in catechol agonist binding FT and receptor activation (By similarity). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential). FT DISULFID 108 186 By similarity. SQ SEQUENCE 432 AA; 49137 MW; 1A52F0283C663DA7 CRC64; MHNLSYASEE DTYTDTDFTP SGNSTNSTSY SPATIIGLAG LVSFLILFTI VGNVLVVIAV LTSRALKPPQ NLFLVSLASA DILVATLIIP FSLANELMGY WFFGEVWCNI YLALDVLFCT SSIVHLCAIS LDRYWSVTQA VEYNLKRTPR RVKGMIVVVW LISAVISFPP LISMDRNTVD ERRPMCQLND HTWYILYSSI GSFFAPCVIM ILVYIRIYQV AKTRTRNMSE KRRDPDGGSG TPRLENGLSR EDSRRENGHC SSSPGERKPA EDNPDADLED SSSSDEKAKR SQNETAPSKK DRRSSRKNSS SSKHSSRKSR ASSKSLDLFS SRRKRRNTIS RKKISQAREK RFTFVLAVVM GVFVVCWFPF FFSYSLYGIC REPCAIPDPL FKFFFWIGYC NSSLNPVIYT IFNQDFRRAF QKILCKSWKR SF // ID ADA2C_MOUSE STANDARD; PRT; 458 AA. AC Q01337; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 18-APR-2006, entry version 46. DE Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C DE adrenoreceptor) (Alpha-2 adrenergic receptor subtype C4). GN Name=Adra2c; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=92342131; PubMed=1353249; RA Link R.E., Daunt D.A., Barsh G., Chruscinski A.J., Kobilka B.K.; RT "Cloning of two mouse genes encoding alpha 2-adrenergic receptor RT subtypes and identification of a single amino acid in the mouse alpha RT 2-C10 homolog responsible for an interspecies variation in antagonist RT binding."; RL Mol. Pharmacol. 42:16-27(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=DBA/2; RX MEDLINE=93250567; PubMed=8387367; RA Chang Y.-H., Chang A.C., Chen W.-M., Chang N.-C.A.; RT "Molecular characterization of a murine homologue of alpha 2C4 RT adrenoceptor subtype gene."; RL Biochem. Mol. Biol. Int. 29:467-474(1993). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. CC -!- INTERACTION: CC Q14232:EIF2B1 (xeno); NbExp=1; IntAct=EBI-491121, EBI-491065; CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M99376; AAA37212.1; -; Genomic_DNA. DR EMBL; M97516; AAA37183.1; -; Genomic_DNA. DR PIR; A48392; A48392. DR PIR; I49480; I49480. DR UniGene; Mm.57205; -. DR HSSP; P08913; 1HLL. DR IntAct; Q01337; -. DR Ensembl; ENSMUSG00000045318; Mus musculus. DR MGI; MGI:87936; Adra2c. DR GO; GO:0004938; F:alpha2-adrenergic receptor activity; TAS. DR GO; GO:0004930; F:G-protein coupled receptor activity; IDA. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IDA. DR InterPro; IPR000735; Adren_rcpt_A2C. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00560; ADRENRGCA2CR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphorylation; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 458 Alpha-2C adrenergic receptor. FT /FTId=PRO_0000069106. FT TOPO_DOM 1 51 Extracellular (Potential). FT TRANSMEM 52 76 1 (Potential). FT TOPO_DOM 77 88 Cytoplasmic (Potential). FT TRANSMEM 89 114 2 (Potential). FT TOPO_DOM 115 124 Extracellular (Potential). FT TRANSMEM 125 147 3 (Potential). FT TOPO_DOM 148 168 Cytoplasmic (Potential). FT TRANSMEM 169 191 4 (Potential). FT TOPO_DOM 192 207 Extracellular (Potential). FT TRANSMEM 208 231 5 (Potential). FT TOPO_DOM 232 379 Cytoplasmic (Potential). FT TRANSMEM 380 403 6 (Potential). FT TOPO_DOM 404 416 Extracellular (Potential). FT TRANSMEM 417 437 7 (Potential). FT TOPO_DOM 438 458 Cytoplasmic (Potential). FT COMPBIAS 291 305 Arg-rich (basic). FT SITE 131 131 Implicated in ligand binding (By FT similarity). FT SITE 214 214 Implicated in catechol agonist binding FT and receptor activation (By similarity). FT SITE 218 218 Implicated in catechol agonist binding FT and receptor activation (By similarity). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT DISULFID 124 202 By similarity. FT CONFLICT 196 196 G -> V (in Ref. 2). FT CONFLICT 296 296 G -> A (in Ref. 2). FT CONFLICT 298 298 L -> V (in Ref. 2). SQ SEQUENCE 458 AA; 49906 MW; C0A8BDF0302BF1FB CRC64; MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWV PPPGQYSAGA VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSF YRRPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRGP AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE FFLSRRRRAR SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL YGICREACQL PEPLFKFFFW IGYCNSSLNP VIYTVFNQDF RRSFKHILFR RRRRGFRQ // ID AA2DA_BRARE STANDARD; PRT; 408 AA. AC Q8JG70; DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 04-APR-2006, entry version 21. DE Alpha-2Da adrenergic receptor (Alpha-2Da adrenoceptor) (Alpha-2Da DE adrenoreceptor) (Alpha(2Da)AR). GN Name=adra2da; OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12949138; DOI=10.1093/molbev/msg224; RA Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., RA Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.; RT "Identification of duplicated fourth alpha2-adrenergic receptor RT subtype by cloning and mapping of five receptor genes in zebrafish."; RL Mol. Biol. Evol. 21:14-28(2004). RN [2] RP FUNCTION, AND 3D-STRUCTURE MODELING. RX PubMed=15655522; DOI=10.1038/sj.bjp.0706057; RA Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., RA Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.; RT "Conserved structural, pharmacological and functional properties among RT the three human and five zebrafish alpha2-adrenoceptors."; RL Br. J. Pharmacol. 144:165-177(2005). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. The order of potency for this receptor is CC dexmedetomidine > norepinephrine > epinephrine > oxymetazoline. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY120895; AAM78031.1; -; Genomic_DNA. DR UniGene; Dr.27182; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSDARG00000012740; Danio rerio. DR ZFIN; ZDB-GENE-021010-4; adra2da. DR GO; GO:0005887; C:integral to plasma membrane; IC. DR GO; GO:0004938; F:alpha2-adrenergic receptor activity; IDA. DR GO; GO:0007194; P:negative regulation of adenylate cyclase ac...; IDA. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 408 Alpha-2Da adrenergic receptor. FT /FTId=PRO_0000069007. FT TOPO_DOM 1 30 Extracellular (Potential). FT TRANSMEM 31 55 1 (Potential). FT TOPO_DOM 56 67 Cytoplasmic (Potential). FT TRANSMEM 68 93 2 (Potential). FT TOPO_DOM 94 103 Extracellular (Potential). FT TRANSMEM 104 126 3 (Potential). FT TOPO_DOM 127 147 Cytoplasmic (Potential). FT TRANSMEM 148 170 4 (Potential). FT TOPO_DOM 171 181 Extracellular (Potential). FT TRANSMEM 182 205 5 (Potential). FT TOPO_DOM 206 332 Cytoplasmic (Potential). FT TRANSMEM 333 356 6 (Potential). FT TOPO_DOM 357 369 Extracellular (Potential). FT TRANSMEM 370 390 7 (Potential). FT TOPO_DOM 391 408 Cytoplasmic (Potential). FT SITE 110 110 Implicated in ligand binding (By FT similarity). FT SITE 188 188 Implicated in catechol agonist binding FT and receptor activation (By similarity). FT SITE 192 192 Implicated in catechol agonist binding FT and receptor activation (By similarity). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT DISULFID 103 176 By similarity. SQ SEQUENCE 408 AA; 46199 MW; 5535ADE8177FB860 CRC64; MSVTPTANST EEAANITASP RLWPYTEPAS AIIILVVSLI ILLTIVGNVL VIVAVLTSRA LRAPQNLFLV SLACADILVA TLVIPFSLAN EIMGYWYFGS TWCAFYLALD VLFCTSSIVH LCAISLDRYW SVTKAVRYNL KRTPRRIKCM IAVVWLISAV ISFPPLIMTK HDEKECLIND ETWYILSSCA VSFFAPGLIM ITVYCKIYRV AKQRSSTVFV AKNGLERQPS QSETCFVRKD KFEKESPSSN SSESAQRQEE LDDIDLEESA ASDSRARGSR FSKRRRVEGE RRGPQRSCRV SWAAHQEPGS RQQQLASKSK VAQMREKRFT FVLAVVMGVF VLCWFPFFFT YSLQAVCGER CGPPEALFKL FFWIGYCNSS VNPIIYTIFN RDFRKAFKKV VCWSAQRT // ID ADA2A_BRARE STANDARD; PRT; 388 AA. AC Q90WY4; DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 04-APR-2006, entry version 24. DE Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A DE adrenoreceptor) (Alpha(2A)AR). GN Name=adra2a; OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12949138; DOI=10.1093/molbev/msg224; RA Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., RA Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.; RT "Identification of duplicated fourth alpha2-adrenergic receptor RT subtype by cloning and mapping of five receptor genes in zebrafish."; RL Mol. Biol. Evol. 21:14-28(2004). RN [2] RP FUNCTION, AND 3D-STRUCTURE MODELING. RX PubMed=15655522; DOI=10.1038/sj.bjp.0706057; RA Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., RA Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.; RT "Conserved structural, pharmacological and functional properties among RT the three human and five zebrafish alpha2-adrenoceptors."; RL Br. J. Pharmacol. 144:165-177(2005). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. The order of potency for this receptor is CC dexmedetomidine > oxymetazoline = epinephrine > norepinephrine. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY048971; AAL07510.1; -; Genomic_DNA. DR UniGene; Dr.30878; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSDARG00000028820; Danio rerio. DR ZFIN; ZDB-GENE-021010-1; adra2a. DR GO; GO:0005887; C:integral to plasma membrane; IC. DR GO; GO:0004938; F:alpha2-adrenergic receptor activity; IDA. DR GO; GO:0007194; P:negative regulation of adenylate cyclase ac...; IDA. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 388 Alpha-2A adrenergic receptor. FT /FTId=PRO_0000069084. FT TOPO_DOM 1 22 Extracellular (Potential). FT TRANSMEM 23 48 1 (Potential). FT TOPO_DOM 49 59 Cytoplasmic (Potential). FT TRANSMEM 60 85 2 (Potential). FT TOPO_DOM 86 95 Extracellular (Potential). FT TRANSMEM 96 118 3 (Potential). FT TOPO_DOM 119 138 Cytoplasmic (Potential). FT TRANSMEM 139 162 4 (Potential). FT TOPO_DOM 163 173 Extracellular (Potential). FT TRANSMEM 174 198 5 (Potential). FT TOPO_DOM 199 311 Cytoplasmic (Potential). FT TRANSMEM 312 337 6 (Potential). FT TOPO_DOM 338 344 Extracellular (Potential). FT TRANSMEM 345 368 7 (Potential). FT TOPO_DOM 369 388 Cytoplasmic (Potential). FT COMPBIAS 309 352 Phe-rich. FT SITE 102 102 Implicated in ligand binding (By FT similarity). FT SITE 181 181 Implicated in catechol agonist binding FT and receptor activation (By similarity). FT SITE 185 185 Implicated in catechol agonist binding FT and receptor activation (By similarity). FT LIPID 380 380 S-palmitoyl cysteine (By similarity). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT DISULFID 95 169 By similarity. SQ SEQUENCE 388 AA; 43997 MW; 431965A04E1986DD CRC64; MICGANATNG TNATKEYTLL VALPLSIAVG LLILLIIFGN VLVIIAVFTS RALRAPQNLF LVSLASADIL VATLVMPFSL ANELMGMWTF GGVWCEIYLA LDVLFCTASI THLCAISLDR YWSITQAIEY NLKRTPQRIK RIIFIVWIIA AVISCPPLIT MKKSEGDICD INKEKWYIVS SCIGSFFLPC IIMVLVYIRI YQIAKKRTRA PPGDHRKNEV GKKENDPHEK LNGIQNAEPD DKDEINGVDM EESSSSDHKV SNPCSLKKKS SKGKTKLSQI KPGDGDKTEA CQTTKASRWK GRQNREKRFT FVLAVVIGVF VICWFPFFFT YTFTAFCDCC VPETLFKFFF WFGYCNSSLN PIIYTIFNND FRRSFKKILC RRDKRRVV // ID ADA2B_CAVPO STANDARD; PRT; 448 AA. AC Q60475; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 21-MAR-2006, entry version 40. DE Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2B DE adrenoreceptor). GN Name=ADRA2B; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Hartley; RX MEDLINE=96152573; PubMed=8573196; DOI=10.1016/0006-2952(95)02179-5; RA Svensson S.P., Bailey T.J., Porter A.C., Richman J.G., Regan J.W.; RT "Heterologous expression of the cloned guinea pig alpha 2A, alpha 2B, RT and alpha 2C adrenoceptor subtypes. Radioligand binding and functional RT coupling to a cAMP-responsive reporter gene."; RL Biochem. Pharmacol. 51:291-300(1996). CC -!- FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- CC induced inhibition of adenylate cyclase through the action of G CC proteins. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U25723; AAA67075.1; -; Genomic_DNA. DR HSSP; P08913; 1HLL. DR InterPro; IPR000207; Adren_rcpt_A2B. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF89; A_receptorA1B; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00559; ADRENRGCA2BR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Lipoprotein; Membrane; Palmitate; KW Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 448 Alpha-2B adrenergic receptor. FT /FTId=PRO_0000069087. FT TOPO_DOM 1 12 Extracellular (Potential). FT TRANSMEM 13 38 1 (Potential). FT TOPO_DOM 39 49 Cytoplasmic (Potential). FT TRANSMEM 50 75 2 (Potential). FT TOPO_DOM 76 85 Extracellular (Potential). FT TRANSMEM 86 108 3 (Potential). FT TOPO_DOM 109 130 Cytoplasmic (Potential). FT TRANSMEM 131 153 4 (Potential). FT TOPO_DOM 154 168 Extracellular (Potential). FT TRANSMEM 169 192 5 (Potential). FT TOPO_DOM 193 370 Cytoplasmic (Potential). FT TRANSMEM 371 394 6 (Potential). FT TOPO_DOM 395 403 Extracellular (Potential). FT TRANSMEM 404 427 7 (Potential). FT TOPO_DOM 428 448 Cytoplasmic (Potential). FT COMPBIAS 294 309 Asp/Glu-rich (acidic). FT SITE 92 92 Implicated in ligand binding (By FT similarity). FT SITE 175 175 Implicated in catechol agonist binding FT (By similarity). FT SITE 179 179 Implicated in catechol agonist binding FT (By similarity). FT LIPID 440 440 S-palmitoyl cysteine (Potential). FT DISULFID 85 163 By similarity. SQ SEQUENCE 448 AA; 49597 MW; 8384F8757E404777 CRC64; MDHQEPYSVQ ATAAIAAVIT FLILFTIFGN ALVILAVLTS RSLPAPQNLF LVSLAAADIL VATLIIPFSL ANELLGYWYF WRTWCEVYLA LDVLFCTSSI VHLCAISLDR YWAVSRALEY NSKRTPRRIK CIILTVWLIA AVISLPPLIY KGDQGPSPRG PQCKINQEAW YILASSIGSF FAPCLIMILV YLRIYLIAKR SHRRGPRAKG GPGEGESKES RPSPGGAPAS AKVPPLASPL SSTGEANGHP KPTGEKEEGE TSEDPGARTL PPSWAALPTS GQGQKKAVVL APAEEEAEEE EEEEGDECEP QAAPGLPASM CSPSLQQPQG SRVLATLRGQ VLLGRGVGAV DGQWWRRRTQ MTREKRFTFV LAVVIGVFVL CWFPFFFTYS LGAICPQHCK VPHGLFQFFF WIGYCNSSLN PVIYTIFNQD FRRAFRRILC RQWTQTAW // ID DRD2L_FUGRU STANDARD; PRT; 463 AA. AC P53453; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 07-MAR-2006, entry version 32. DE D(2)-like dopamine receptor. GN Name=D215; OS Fugu rubripes (Japanese pufferfish) (Takifugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; OC Tetradontoidea; Tetraodontidae; Takifugu. OX NCBI_TaxID=31033; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=95309911; PubMed=7789977; RA Machae A.D., Brenner S.; RT "Analysis of the dopamine receptor family in the compact genome of the RT puffer fish Fugu rubripes."; RL Genomics 25:436-446(1995). CC -!- FUNCTION: Receptor for dopamine. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X80175; CAA56456.1; -; Genomic_DNA. DR HSSP; P08913; 1HLL. DR InterPro; IPR001922; Dopa_D2_rcpt. DR InterPro; IPR000929; Dopamine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00567; DOPAMINED2R. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 463 D(2)-like dopamine receptor. FT /FTId=PRO_0000069392. FT TOPO_DOM 1 35 Extracellular (Potential). FT TRANSMEM 36 58 1 (Potential). FT TOPO_DOM 59 69 Cytoplasmic (Potential). FT TRANSMEM 70 95 2 (Potential). FT TOPO_DOM 96 106 Extracellular (Potential). FT TRANSMEM 107 128 3 (Potential). FT TOPO_DOM 129 149 Cytoplasmic (Potential). FT TRANSMEM 150 172 4 (Potential). FT TOPO_DOM 173 187 Extracellular (Potential). FT TRANSMEM 188 211 5 (Potential). FT TOPO_DOM 212 392 Cytoplasmic (Potential). FT TRANSMEM 393 416 6 (Potential). FT TOPO_DOM 417 425 Extracellular (Potential). FT TRANSMEM 426 449 7 (Potential). FT TOPO_DOM 450 463 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 16 16 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). FT DISULFID 105 183 By similarity. SQ SEQUENCE 463 AA; 52120 MW; A54B178D7718AF6B CRC64; MDVFTQYAYN DSIFDNGTWS ANETTKDETH PYNYYAMLLT LLIFVIVFGN VLVCMAVSRE KALQTTTNYL IVSLAVADLL VATLVMPWVV YLEVVGEWRF SKIHCDIFVT LDVMMCTASI LNLCAISIDR YTAVAMPMLY NTRYSSRRRV TVMISVVWVL SFAISCPLLF GLNNTATRDQ SLCFIANPAF VVYSSIVSFY VPFIVTLLVY VQIYVVLRKR RKRVNTKPKQ RLCQAADPDI PTSLKDKCTH PEDVRLCTMI VKSNGSFPVN KKKVIFIKDG VNEVEGLELD ELNYCGGSHK QPPPQQQPRA LGDTPATSHQ LLMSTKANAS PTSTPPTPPE EGQRTEKNGD PTKEAQGNPA PVVALRNGKT QTSLKTLSKR KISQQKEKKA TQMLAIVLGV FIICWLPFFI THILNTHCTR CKVPAEMYNA FTWLGYVNSA VNPIIYTTFN VEFRKAFIKI LHC // ID DRD4_HUMAN STANDARD; PRT; 467 AA. AC P21917; DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 2. DT 18-APR-2006, entry version 64. DE D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine DE receptor). GN Name=DRD4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ALLELE D4.7). RX MEDLINE=92310588; PubMed=1319557; DOI=10.1038/358149a0; RA van Tol H.H., Wu C.M., Guan H.C., Ohara K., Bunzow J.R., Civelli O., RA Kennedy J., Seeman P., Niznik H.B., Jovanovic V.; RT "Multiple dopamine D4 receptor variants in the human population."; RL Nature 358:149-152(1992). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE D4.2). RC TISSUE=Brain; RX MEDLINE=91204054; PubMed=1840645; DOI=10.1038/350610a0; RA van Tol H.H.M., Bunzow J.R., Guan H.-C., Sunahara R.K., Seeman P., RA Niznik H.B., Civelli O.; RT "Cloning of the gene for a human dopamine D4 receptor with high RT affinity for the antipsychotic clozapine."; RL Nature 350:610-614(1991). RN [3] RP 3D-STRUCTURE MODELING. RX MEDLINE=93038566; PubMed=1358063; RA Livingstone C.D., Strange P.G., Naylor L.H.; RT "Molecular modelling of D2-like dopamine receptors."; RL Biochem. J. 287:277-282(1992). RN [4] RP VARIANT GLY-194. RX MEDLINE=95243275; PubMed=7726213; RA Seeman P., Ulpian C., Chouinard G., van Tol H.H.M., Dwosh H., RA Lieberman J.A., Siminovitch K., Liu I.S.C., Waye J., Voruganti P., RA Hudson C., Serjeant G.R., Masibay A.S., Seeman M.V.; RT "Dopamine D4 receptor variant, D4-glycine-194, in Africans, but not in RT Caucasians: no association with schizophrenia."; RL Am. J. Med. Genet. 54:384-390(1994). CC -!- FUNCTION: This is one of the five types (D1 to D5) of receptors CC for dopamine. The activity of this receptor is mediated by G CC proteins which inhibit adenylyl cyclase. CC -!- SUBUNIT: Interacts with CLIC6 (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- POLYMORPHISM: The number of repeats is highly polymorphic and CC varies among different alleles. The sequence shown is that of CC allele D4.7. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L12398; AAB59386.1; -; mRNA. DR EMBL; L12397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; S15079; DYHUD4. DR UniGene; Hs.99922; -. DR HGNC; HGNC:3025; DRD4. DR MIM; 126452; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004952; F:dopamine receptor activity; TAS. DR GO; GO:0007166; P:cell surface receptor linked signal transdu...; TAS. DR GO; GO:0007212; P:dopamine receptor signaling pathway; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR002185; DopaD4_rcpt. DR InterPro; IPR000929; Dopamine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00569; DOPAMINED4R. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Repeat; Transducer; Transmembrane. FT CHAIN 1 467 D(4) dopamine receptor. FT /FTId=PRO_0000069401. FT TOPO_DOM 1 37 Extracellular (Potential). FT TRANSMEM 38 60 1 (Potential). FT TOPO_DOM 61 70 Cytoplasmic (Potential). FT TRANSMEM 71 93 2 (Potential). FT TOPO_DOM 94 109 Extracellular (Potential). FT TRANSMEM 110 131 3 (Potential). FT TOPO_DOM 132 151 Cytoplasmic (Potential). FT TRANSMEM 152 175 4 (Potential). FT TOPO_DOM 176 191 Extracellular (Potential). FT TRANSMEM 192 213 5 (Potential). FT TOPO_DOM 214 394 Cytoplasmic (Potential). FT TRANSMEM 395 417 6 (Potential). FT TOPO_DOM 418 426 Extracellular (Potential). FT TRANSMEM 427 449 7 (Potential). FT TOPO_DOM 450 467 Cytoplasmic (Potential). FT REPEAT 249 264 1 (approximate). FT REPEAT 265 280 2. FT REPEAT 281 296 3. FT REPEAT 297 312 4. FT REPEAT 313 328 5. FT REPEAT 329 344 6. FT REPEAT 345 360 7 (approximate). FT REGION 249 360 7 X 16 AA approximate tandem repeats of FT [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A- FT P. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 108 185 By similarity. FT VARIANT 194 194 V -> G (in Afro-Caribbeans; FT dbSNP:1800443). FT /FTId=VAR_003464. FT VARIANT 265 344 Missing (in allele D4.2). FT /FTId=VAR_003465. FT VARIANT 281 328 Missing (in allele D4.4). FT /FTId=VAR_003466. FT VARIANT 329 329 P -> A (in allele D4.4). FT /FTId=VAR_003467. FT VARIANT 332 332 G -> S (in allele D4.4). FT /FTId=VAR_003468. SQ SEQUENCE 467 AA; 48361 MW; B6FF2E09269A02AF CRC64; MGNRSTADAD GLLAGRGPAA GASAGASAGL AGQGAAALVG GVLLIGAVLA GNSLVCVSVA TERALQTPTN SFIVSLAAAD LLLALLVLPL FVYSEVQGGA WLLSPRLCDA LMAMDVMLCT ASIFNLCAIS VDRFVAVAVP LRYNRQGGSR RQLLLIGATW LLSAAVAAPV LCGLNDVRGR DPAVCRLEDR DYVVYSSVCS FFLPCPLMLL LYWATFRGLQ RWEVARRAKL HGRAPRRPSG PGPPSPTPPA PRLPQDPCGP DCAPPAPGLP RGPCGPDCAP AAPGLPPDPC GPDCAPPAPG LPQDPCGPDC APPAPGLPRG PCGPDCAPPA PGLPQDPCGP DCAPPAPGLP PDPCGSNCAP PDAVRAAALP PQTPPQTRRR RRAKITGRER KAMRVLPVVV GAFLLCWTPF FVVHITQALC PACSVPPRLV SAVTWLGYVN SALNPVIYTV FNAEFRNVFR KALRACC // ID GPR9_BALAM STANDARD; PRT; 476 AA. AC Q93126; Q93128; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 21-MAR-2006, entry version 44. DE Probable G-protein coupled receptor No9. OS Balanus amphitrite (Barnacle). OC Eukaryota; Metazoa; Arthropoda; Crustacea; Maxillopoda; Cirripedia; OC Thoracica; Sessilia; Balanidae; Balanus. OX NCBI_TaxID=32267; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Darwin; RX MEDLINE=97074655; PubMed=8917082; DOI=10.1016/0378-1119(96)00130-8; RA Isoai A., Kawahara H., Okazaki Y., Shizuri Y.; RT "Molecular cloning of a new member of the putative G protein-coupled RT receptor gene from barnacle Balanus amphitrite."; RL Gene 175:95-100(1996). CC -!- FUNCTION: Orphan G-protein coupled receptor. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; D78363; BAA11375.1; -; Genomic_DNA. DR EMBL; D78587; BAA11424.1; -; Genomic_DNA. DR PIR; JC5042; JC5042. DR HSSP; P08913; 1HLL. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 476 Probable G-protein coupled receptor No9. FT /FTId=PRO_0000069659. FT TOPO_DOM 1 36 Extracellular (Potential). FT TRANSMEM 37 60 1 (Potential). FT TOPO_DOM 61 69 Cytoplasmic (Potential). FT TRANSMEM 70 93 2 (Potential). FT TOPO_DOM 94 103 Extracellular (Potential). FT TRANSMEM 104 127 3 (Potential). FT TOPO_DOM 128 152 Cytoplasmic (Potential). FT TRANSMEM 153 172 4 (Potential). FT TOPO_DOM 173 200 Extracellular (Potential). FT TRANSMEM 201 221 5 (Potential). FT TOPO_DOM 222 375 Cytoplasmic (Potential). FT TRANSMEM 376 396 6 (Potential). FT TOPO_DOM 397 406 Extracellular (Potential). FT TRANSMEM 407 430 7 (Potential). FT TOPO_DOM 431 476 Cytoplasmic (Potential). FT SITE 113 113 Implicated in ligand binding (By FT similarity). FT SITE 208 208 Implicated in ligand binding (By FT similarity). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT CARBOHYD 17 17 N-linked (GlcNAc...) (Potential). FT DISULFID 106 192 By similarity. FT CONFLICT 454 454 R -> A (in Ref. 1; BAA11424). SQ SEQUENCE 476 AA; 53246 MW; 0F55B51595D5CD06 CRC64; MEGPPLSPAP ADNVTLNVSC GRPATLFDWA DHRLISLLAL AFLNLMVVAG NLLVVMAVFV HSKLRTVTNL FIVSLACADL LVGMLVLPFS ATLEVLDVWL YGDVWCSVWL AVDVWMCTSS ILNLCAISLD RYLAVSQPIS YPSLMSTRRA KQLIAAVWVL SFVICFPPLV GWNDRPGTLI GSRGSSACRL TCELTNERGY VIYSALGSFF LPSTVMLFFY GRIYRTAVST TRAIAQGFRT TKEDEEGRLT LRIHRGRSVT QRAEQAAAGG ARAHGQVRLT LSEPGARRQN KPSFVVHCRE DSRAKNQYEI YTVVEGDSRP GRRVPQPQRP AKKLSSASQS SEDDSRPPRF ISRVSRRNVR HQARRFRMET KAAKTVGIIV GLFILCWLPF FVCYLVRGFC ADCVPPLLFS VFFWLGYCNS AVNPCVYALC SRDFRFAFSS ILCKCVCRRG AMERRFRRTL LVGNRSQTEE DCEVAD // ID 5HT7R_MOUSE STANDARD; PRT; 448 AA. AC P32304; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 18-APR-2006, entry version 49. DE 5-hydroxytryptamine 7 receptor (5-HT-7) (Serotonin receptor 7) (5-HT- DE X) (5HT7). GN Name=Htr7; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=93360913; PubMed=8394987; RA Plassat J.-L., Amlaiky N., Hen R.; RT "Molecular cloning of a mammalian serotonin receptor that activates RT adenylate cyclase."; RL Mol. Pharmacol. 44:229-236(1993). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that stimulate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Z23107; CAA80654.1; -; mRNA. DR PIR; I48779; S36402. DR UniGene; Mm.254266; -. DR Ensembl; ENSMUSG00000024798; Mus musculus. DR MGI; MGI:99841; Htr7. DR InterPro; IPR001069; 5HT_7_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Melcrt_ACTH_rcpt. DR PANTHER; PTHR19266:SF115; 5HT7_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00652; 5HT7RECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 448 5-hydroxytryptamine 7 receptor. FT /FTId=PRO_0000068980. FT TOPO_DOM 1 84 Extracellular (Potential). FT TRANSMEM 85 111 1 (Potential). FT TOPO_DOM 112 121 Cytoplasmic (Potential). FT TRANSMEM 122 147 2 (Potential). FT TOPO_DOM 148 159 Extracellular (Potential). FT TRANSMEM 160 181 3 (Potential). FT TOPO_DOM 182 201 Cytoplasmic (Potential). FT TRANSMEM 202 225 4 (Potential). FT TOPO_DOM 226 240 Extracellular (Potential). FT TRANSMEM 241 263 5 (Potential). FT TOPO_DOM 264 331 Cytoplasmic (Potential). FT TRANSMEM 332 355 6 (Potential). FT TOPO_DOM 356 367 Extracellular (Potential). FT TRANSMEM 368 390 7 (Potential). FT TOPO_DOM 391 448 Cytoplasmic (Potential). FT LIPID 404 404 S-palmitoyl cysteine (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 69 69 N-linked (GlcNAc...) (Potential). FT DISULFID 158 234 By similarity. SQ SEQUENCE 448 AA; 49861 MW; 01C7380300991C30 CRC64; MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA GNCLVVISVC FVKNVRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK CMAKMILSVW PLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK EVEECANLSR LLKHERKNIS SFKREQKAAT TLGIIVGAFT VCWLPFFLLS TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYSFF NRDLRTTYRS LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT // ID 5HT1R_DROME STANDARD; PRT; 564 AA. AC P20905; Q9VA21; DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1991, sequence version 1. DT 04-APR-2006, entry version 66. DE 5-hydroxytryptamine receptor 1 (5-HT receptor) (Serotonin receptor 1) DE (5HT-dro). GN Name=5-HT7; Synonyms=5HT-R1; ORFNames=CG12073; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY. RC STRAIN=Oregon-R; TISSUE=Head; RX MEDLINE=91062395; PubMed=2174167; RA Witz P., Amlaiky N., Plassat J.-L., Maroteaux L., Borrelli E., Hen R.; RT "Cloning and characterization of a Drosophila serotonin receptor that RT activates adenylate cyclase."; RL Proc. Natl. Acad. Sci. U.S.A. 87:8940-8944(1990). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Embryo; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.E.; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins which activate adenylate CC cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed predominantly in adult heads. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M55533; AAA28305.1; -; mRNA. DR EMBL; AE003776; AAF57104.1; -; Genomic_DNA. DR EMBL; AY118491; AAM49860.1; -; mRNA. DR UniGene; Dm.1903; -. DR HSSP; P08913; 1HLL. DR Ensembl; CG12073; Drosophila melanogaster. DR FlyBase; FBgn0004573; 5-HT7. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-014259-MONOMER; -. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007192; P:serotonin receptor, adenylate cyclase activ...; TAS. DR InterPro; IPR000929; Dopamine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Complete proteome; G-protein coupled receptor; Membrane; Receptor; KW Repeat; Transducer; Transmembrane. FT CHAIN 1 564 5-hydroxytryptamine receptor 1. FT /FTId=PRO_0000068941. FT TRANSMEM 29 51 0 (Potential). FT TRANSMEM 165 188 1 (Potential). FT TOPO_DOM 189 198 Cytoplasmic (Potential). FT TRANSMEM 199 222 2 (Potential). FT TOPO_DOM 223 236 Extracellular (Potential). FT TRANSMEM 237 258 3 (Potential). FT TOPO_DOM 259 278 Cytoplasmic (Potential). FT TRANSMEM 279 302 4 (Potential). FT TOPO_DOM 303 330 Extracellular (Potential). FT TRANSMEM 331 353 5 (Potential). FT TOPO_DOM 354 454 Cytoplasmic (Potential). FT TRANSMEM 455 476 6 (Potential). FT TOPO_DOM 477 487 Extracellular (Potential). FT TRANSMEM 488 510 7 (Potential). FT TOPO_DOM 511 564 Cytoplasmic (Potential). FT REPEAT 89 90 1. FT REPEAT 91 92 2. FT REPEAT 93 94 3. FT REPEAT 95 96 4. FT REPEAT 97 98 5. FT REPEAT 99 100 6. FT REPEAT 101 102 7. FT REPEAT 103 104 8. FT REPEAT 105 106 9. FT REGION 89 106 9 X 2 AA tandem repeats of G-S. FT DISULFID 235 314 By similarity. SQ SEQUENCE 564 AA; 60861 MW; 0C8B9F8DA63D8095 CRC64; MALSGQDWRR HQSHRQHRNH RTQGNHQKLI STATLTLFVL FLSSWIAYAA GKATVPAPLV EGETESATSQ DFNSSSAFLG AIASASSTGS GSGSGSGSGS GSGSGSYGLA SMNSSPIAIV SYQGITSSNL GDSNTTLVPL SDTPLLLEEF AAGEFVLPPL TSIFVSIVLL IVILGTVVGN VLVCIAVCMV RKLRRPCNYL LVSLALSDLC VALLVMPMAL LYEVLEKWNF GPLLCDIWVS FDVLCCTASI LNLCAISVDR YLAITKPLEY GVKRTPRRMM LCVGIVWLAA ACISLPPLLI LGNEHEDEEG QPICTVCQNF AYQIYATLGS FYIPLSVMLF VYYQIFRAAR RIVLEEKRAQ THLQQALNGT GSPSAPQAPP LGHTELASSG NGQRHSSVGN TSLTYSTCGG LSSGGGALAG HGSGGGVSGS TGLLGSPHHK KLRFQLAKEK KASTTLGIIM SAFTVCWLPF FILALIRPFE TMHVPASLSS LFLWLGYANS LLNPIIYATL NRDFRKPFQE ILYFRCSSLN TMMRENYYQD QYGEPPSQRV MLGDERHGAR ESFL // ID OCTB3_DROME STANDARD; PRT; 440 AA. AC Q4LBB6; Q2PDR1; Q2PDR3; Q2PDR4; Q2PDR5; Q2PDR6; Q4LBB5; Q4LBB7; AC Q4LBB8; Q8INI6; Q8INI7; Q9VG57; DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot. DT 25-OCT-2005, sequence version 3. DT 04-APR-2006, entry version 11. DE Octopamine receptor beta-3R (DmOct-beta-3R). GN Name=Oct-beta-3R; Synonyms=Oct-beta-3; ORFNames=CG33959; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D). RC TISSUE=Head; RX PubMed=15998303; DOI=10.1111/j.1471-4159.2005.03251.x; RA Maqueira B., Chatwin H., Evans P.D.; RT "Identification and characterization of a novel family of Drosophila RT beta-adrenergic-like octopamine G-protein coupled receptors."; RL J. Neurochem. 94:547-560(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- FUNCTION: Receptor for octopamine. Octopamine (OA) is a CC neurotransmitter, neurohormone, and neuromodulator in CC invertebrates. The activity of this receptor is mediated by G CC proteins which activate adenylyl cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein CC (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=D; Synonyms=variant A; CC IsoId=Q4LBB6-4; Sequence=Displayed; CC Name=A; Synonyms=variant D; CC IsoId=Q4LBB6-2; Sequence=VSP_051835; CC Name=B; Synonyms=variant C; CC IsoId=Q4LBB6-1; Sequence=VSP_051839; CC Name=C; Synonyms=variant B; CC IsoId=Q4LBB6-3; Sequence=VSP_051837; CC Name=E; CC IsoId=Q4LBB6-5; Sequence=VSP_051836; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AJ884591; CAI56424.1; -; mRNA. DR EMBL; AJ884592; CAI56425.1; -; mRNA. DR EMBL; AJ884593; CAI56426.1; -; mRNA. DR EMBL; AJ884594; CAI56427.1; -; mRNA. DR EMBL; AE003696; ABC66169.1; -; Genomic_DNA. DR EMBL; AE003696; ABC66170.1; -; Genomic_DNA. DR EMBL; AE003696; ABC66171.1; -; Genomic_DNA. DR EMBL; AE003696; ABC66172.1; -; Genomic_DNA. DR EMBL; AE003696; ABC66174.1; -; Genomic_DNA. DR FlyBase; FBgn0053959; Oct-beta-3R. DR GO; GO:0016021; C:integral to membrane; ISS. DR GO; GO:0004989; F:octopamine receptor activity; ISS. DR GO; GO:0007189; P:G-protein signaling, adenylate cyclase acti...; ISS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001671; Melcrt_ACTH_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00534; MCRFAMILY. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; Complete proteome; G-protein coupled receptor; KW Glycoprotein; Membrane; Receptor; Transducer; Transmembrane. FT CHAIN 1 440 Octopamine receptor beta-3R. FT /FTId=PRO_0000069961. FT TOPO_DOM 1 143 Extracellular (Potential). FT TRANSMEM 144 164 1 (Potential). FT TOPO_DOM 165 171 Cytoplasmic (Potential). FT TRANSMEM 172 192 2 (Potential). FT TOPO_DOM 193 218 Extracellular (Potential). FT TRANSMEM 219 241 3 (Potential). FT TOPO_DOM 242 258 Cytoplasmic (Potential). FT TRANSMEM 259 279 4 (Potential). FT TOPO_DOM 280 305 Extracellular (Potential). FT TRANSMEM 306 326 5 (Potential). FT TOPO_DOM 327 353 Cytoplasmic (Potential). FT TRANSMEM 354 374 6 (Potential). FT TOPO_DOM 375 386 Extracellular (Potential). FT TRANSMEM 387 407 7 (Potential). FT TOPO_DOM 408 440 Cytoplasmic (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CARBOHYD 113 113 N-linked (GlcNAc...) (Potential). FT CARBOHYD 117 117 N-linked (GlcNAc...) (Potential). FT CARBOHYD 196 196 N-linked (GlcNAc...) (Potential). FT VARSPLIC 262 350 Missing (in isoform A). FT /FTId=VSP_051835. FT VARSPLIC 330 351 KEAIRQRKALSRTSSNILLNSA -> N (in isoform FT E). FT /FTId=VSP_051836. FT VARSPLIC 331 440 Missing (in isoform C). FT /FTId=VSP_051837. FT VARSPLIC 351 440 ARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVV FT LFWIGYFNSTLNPLIYAYFNRDFREAFRNTLECVLPCLEKR FT NPYNAYYV -> VHMGHTQQPTSLSYLHPSDCDLNATSARE FT ETHSALSNLEAVPCDRPKDGRPNTRPPAPWASSWASFCSAG FT CPSFCGMSSHRSAVRPAHVPMCSWWCYSGSVTSTPR (in FT isoform B). FT /FTId=VSP_051839. FT CONFLICT 12 12 T -> A (in Ref. 1; CAI56425). FT CONFLICT 98 98 L -> S (in Ref. 1; CAI56426). FT CONFLICT 122 122 A -> T (in Ref. 1). FT CONFLICT 132 132 S -> G (in Ref. 1; CAI56426). FT CONFLICT 211 211 F -> L (in Ref. 1; CAI56426). FT CONFLICT 211 211 F -> P (in Ref. 1; CAI56425). FT CONFLICT 351 351 A -> TSSA (in Ref. 1; CAI56427). FT CONFLICT 370 370 L -> M (in Ref. 1; CAI56427). SQ SEQUENCE 440 AA; 48398 MW; BA0AE6B550A7288A CRC64; MSGVNVADLL ATTMTLPITA AAGAATSQAA ATSATNASHL QPATLTGHIS TTAAAKTTTT PTSSLPITSQ FVDASLTSLS LTATSSDASY SSPFSSYLSS DSTFELLSTV GPNITANGSD IAVDNQAELE ESWLDLSLLL LKGFIFSSII LAAVLGNALV IISVQRNRKL RVITNYFVVS LAMADMLVAL CAMTFNASVE LSGGKWMFGP FMCNVYNSLD VYFSTASILH LCCISVDRYY AIVRPLEYPL NMTHKTVCFM LANVWILPAL ISFTPIFLGW YTTEEHLREI SLHPDQCSFV VNKAYALISS SVSFWIPGIV MLVMYWRIFK EAIRQRKALS RTSSNILLNS ARTLGIIMGV FLLCWLPFFL WYVITSLCGP ACPCPDVLVV VLFWIGYFNS TLNPLIYAYF NRDFREAFRN TLECVLPCLE KRNPYNAYYV // ID 5HT4R_CAVPO STANDARD; PRT; 388 AA. AC O70528; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 21-MAR-2006, entry version 38. DE 5-hydroxytryptamine 4 receptor (5-HT-4) (Serotonin receptor 4) (5- DE HT4). GN Name=HTR4; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Van den Wyngaert I., Gommeren W., Jurzak M., Verhasselt P., Gordon R., RA Leysen J., Luyten W., Bender E.; RT "Cloning and expression of 5-HT4 receptor species and splice RT variants."; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that stimulate adenylate CC cyclase (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=1; CC Comment=A number of isoforms are produced; CC Name=1; CC IsoId=O70528-1; Sequence=Displayed; CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y13585; CAA73912.1; -; mRNA. DR HSSP; P08913; 1HLL. DR InterPro; IPR001520; 5HT4_rcpt. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF48; 5HT4_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01059; 5HT4RECEPTR. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; G-protein coupled receptor; Glycoprotein; KW Lipoprotein; Membrane; Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 388 5-hydroxytryptamine 4 receptor. FT /FTId=PRO_0000068964. FT TOPO_DOM 1 19 Extracellular (Potential). FT TRANSMEM 20 40 1 (Potential). FT TOPO_DOM 41 58 Cytoplasmic (Potential). FT TRANSMEM 59 79 2 (Potential). FT TOPO_DOM 80 93 Extracellular (Potential). FT TRANSMEM 94 116 3 (Potential). FT TOPO_DOM 117 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 4 (Potential). FT TOPO_DOM 159 192 Extracellular (Potential). FT TRANSMEM 193 213 5 (Potential). FT TOPO_DOM 214 260 Cytoplasmic (Potential). FT TRANSMEM 261 281 6 (Potential). FT TOPO_DOM 282 294 Extracellular (Potential). FT TRANSMEM 295 315 7 (Potential). FT TOPO_DOM 316 388 Cytoplasmic (Potential). FT LIPID 329 329 S-palmitoyl cysteine (By similarity). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT DISULFID 93 184 By similarity. SQ SEQUENCE 388 AA; 43726 MW; 3D45B3A37F60D02B CRC64; MDKLDANVSS KEGFGSVEKV VLLTFLSAVI LMAILGNLLV MVAVCRDRQL RKIKTNYFIV SLAFADLLVS VLVMPFGAIE LVQDIWVYGE MFCLVRTSLD VLLTTASIFH LCCISLDRYY AICCQPLVYR NKMTPLRIAL MLGGCWVIPM FISFLPIMQG WNNIGIVDLI EKRKFNQNSN STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHARQIQVLQ RAGAPAEGRP QPADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQLWTAFLWL GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD TVECGGQWES QCHPAASSPL VAAQPIDT // ID DOPR2_DROME STANDARD; PRT; 539 AA. AC Q24563; Q24569; Q9VAJ8; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 04-APR-2006, entry version 53. DE Dopamine receptor 2. GN Name=DopR2; Synonyms=DAMB, DopR99B; ORFNames=CG18741; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORM A), AND FUNCTION. RC STRAIN=Canton-S; TISSUE=Head; RX MEDLINE=96242088; PubMed=8656286; RA Feng G., Hannan F., Reale V., Hon Y.Y., Kousky C.T., Evans P.D., RA Hall L.M.; RT "Cloning and functional characterization of a novel dopamine receptor RT from Drosophila melanogaster."; RL J. Neurosci. 16:3925-3933(1996). RN [2] RP NUCLEOTIDE SEQUENCE (ISOFORM B), FUNCTION, AND TISSUE SPECIFICITY. RC STRAIN=Canton-S; RX MEDLINE=96258265; PubMed=8663989; DOI=10.1016/S0896-6273(00)80139-7; RA Han K.-A., Millar N.S., Grotewiel M.S., Davis R.L.; RT "DAMB, a novel dopamine receptor expressed specifically in Drosophila RT mushroom bodies."; RL Neuron 16:1127-1135(1996). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP NUCLEOTIDE SEQUENCE (ISOFORM B). RC STRAIN=Berkeley; TISSUE=Head; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.E.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for dopamine. The activity of this receptor is CC mediated by G proteins which activate adenylyl cyclase. Also CC capable of generating a calcium signal. In terms of antagonist CC responses, would be classed with the D1-like dopamine receptor CC group. This receptor an attractive candidate for initiating CC biochemical cascades underlying olfactory learning. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=A; CC IsoId=Q24563-1; Sequence=Displayed; CC Name=B; CC IsoId=Q24563-2; Sequence=VSP_001877; CC Note=No experimental confirmation available; CC -!- TISSUE SPECIFICITY: Expressed in both central and peripheral CC nervous systems. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U34383; AAC47161.1; -; mRNA. DR EMBL; U61264; AAB08000.1; -; mRNA. DR EMBL; AE003770; AAF56908.2; -; Genomic_DNA. DR EMBL; AE003770; AAN14180.1; -; Genomic_DNA. DR EMBL; BT010212; AAQ23530.1; -; mRNA. DR UniGene; Dm.2334; -. DR HSSP; P08913; 1HLL. DR Ensembl; CG18741; Drosophila melanogaster. DR FlyBase; FBgn0015129; DopR2. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-013984-MONOMER; -. DR GO; GO:0001590; F:dopamine D1 receptor activity; IDA. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR001174; Galkinase. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00960; LMBPPROTEIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; Complete proteome; G-protein coupled receptor; KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphorylation; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 539 Dopamine receptor 2. FT /FTId=PRO_0000069370. FT TOPO_DOM 1 113 Extracellular (Potential). FT TRANSMEM 114 134 1 (Potential). FT TOPO_DOM 135 145 Cytoplasmic (Potential). FT TRANSMEM 146 166 2 (Potential). FT TOPO_DOM 167 189 Extracellular (Potential). FT TRANSMEM 190 206 3 (Potential). FT TOPO_DOM 207 227 Cytoplasmic (Potential). FT TRANSMEM 228 248 4 (Potential). FT TOPO_DOM 249 266 Extracellular (Potential). FT TRANSMEM 267 287 5 (Potential). FT TOPO_DOM 288 420 Cytoplasmic (Potential). FT TRANSMEM 421 441 6 (Potential). FT TOPO_DOM 442 453 Extracellular (Potential). FT TRANSMEM 454 474 7 (Potential). FT TOPO_DOM 475 539 Cytoplasmic (Potential). FT COMPBIAS 86 89 Poly-Gly. FT COMPBIAS 338 351 Poly-Gly. FT COMPBIAS 357 367 Poly-His. FT LIPID 492 492 S-palmitoyl cysteine (Potential). FT LIPID 493 493 S-palmitoyl cysteine (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT CARBOHYD 47 47 N-linked (GlcNAc...) (Potential). FT CARBOHYD 68 68 N-linked (GlcNAc...) (Potential). FT DISULFID 182 261 By similarity. FT VARSPLIC 511 539 RFATRRCYSTCSLHGIQHVRHNSCEQTYI -> CHVAAAMV FT AASTSFGYHSVNQIDRTLM (in isoform B). FT /FTId=VSP_001877. FT CONFLICT 496 496 K -> E (in Ref. 5). SQ SEQUENCE 539 AA; 59505 MW; 32FDDC0E935AF4B3 CRC64; MVDDNGSSPE VEGAEGAGAP LLALLRVDGL NQTQTRSPSP SFFGSYNISE DVYFYFNGLP TSTELVLNAT TSATSATLSP AMVATGGGGT TTPEPDLSEF LEALPNDRVG LLAFLFLFSF ATVFGNSLVI LAVIRERYLH TATNYFITSL AVADCLVGLV VMPFSALYEV LENTWFFGTD WCDIWRSLDV LFSTASILNL CVISLDRYWA ITDPFSYPMR MTVKRAAGLI AAVWICSSAI SFPAIVWWRA ARDGEMPAYK CTFTEHLGYL VFSSTISFYL PLLVMVFTYC RIYRAAVIQT RSLKIGTKQV LMASGELQLT LRIHRGGTTR DQQNQVSGGG GGGGGGGGGG GSLSHSHSHS HHHHHNHGGG TTTSTPEEPD DEPLSALHNN GLARHRHMGK NFSLSRKLAK FAKEKKAAKT LGIVMGVFII CWLPFFVVNL LSGFCIECIE HEEIVSAIVT WLGWINSCMN PVIYACWSRD FRRAFVRLLC MCCPRKIRRK YQPTMRSKSQ RFATRRCYST CSLHGIQHVR HNSCEQTYI // ID ADRB1_XENLA STANDARD; PRT; 385 AA. AC O42574; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 04-APR-2006, entry version 38. DE Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1 DE adrenoreceptor) (X-BETA1AR). GN Name=adrb1; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98055670; PubMed=9395292; DOI=10.1016/S0014-5793(97)01278-7; RA Devic E., Paquereau L., Kaghad M., Steinberg R., Caput D., RA Audigier Y.; RT "Early expression of a beta1-adrenergic receptor and catecholamines in RT Xenopus oocytes and embryos."; RL FEBS Lett. 417:184-190(1997). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Homologous desensitization of the receptor is mediated by its CC phosphorylation by beta-adrenergic receptor kinase (By CC similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y09213; CAA70415.1; -; mRNA. DR UniGene; Xl.14992; -. DR HSSP; P07700; 1DEP. DR InterPro; IPR000507; Adrgc_rcpt_B1. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF58; Adrgc_receptorB1; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00561; ADRENRGCB1AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 385 Beta-1 adrenergic receptor. FT /FTId=PRO_0000069126. FT TOPO_DOM 1 37 Extracellular (Potential). FT TRANSMEM 38 61 1 (Potential). FT TOPO_DOM 62 71 Cytoplasmic (Potential). FT TRANSMEM 72 88 2 (Potential). FT TOPO_DOM 89 109 Extracellular (Potential). FT TRANSMEM 110 131 3 (Potential). FT TOPO_DOM 132 153 Cytoplasmic (Potential). FT TRANSMEM 154 174 4 (Potential). FT TOPO_DOM 175 200 Extracellular (Potential). FT TRANSMEM 201 223 5 (Potential). FT TOPO_DOM 224 272 Cytoplasmic (Potential). FT TRANSMEM 273 297 6 (Potential). FT TOPO_DOM 298 303 Extracellular (Potential). FT TRANSMEM 304 326 7 (Potential). FT TOPO_DOM 327 385 Cytoplasmic (Potential). FT LIPID 340 340 S-palmitoyl cysteine (By similarity). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Potential). FT DISULFID 108 187 By similarity. SQ SEQUENCE 385 AA; 43309 MW; 0153D05AE49E0C1B CRC64; MGDGWGPMEC RNRSGTPTTV PSPMHPLPEL THQWTMGMTM FMAAIILLIV MGNIMVIVAI GRNQRLQTLT NVFITSLACA DLIMGLFVVP LGATLVVSGR WLYGSIFCEF WTSVDVLCVT ASIETLCVIS IDRYIAITSP FRYQSLLTKG RAKGIVCSVW GISALVSFLP IMMHWWRDTG DPLAMKCYED PGCCDFVTNR AYAIASSIIS FYFPLIIMIF VYIRVFKEAQ KQMKKIDKCE GRFSHSHVLS HGRSSRRILS KILVAKEQKA LKTLGIIMGT FTLCWLPFFL ANVVNVFYRN LIPDKLFLFL NWLGYANSAF NPIIYCRSPD FRKAFKRLLC CPKKADRHLH TTGELSRYSG GFVNSLDTNA LGMCSECNGV RTSLD // ID ADB4C_MELGA STANDARD; PRT; 428 AA. AC P43141; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 21-MAR-2006, entry version 37. DE Beta-4C adrenergic receptor (Beta-4C adrenoceptor) (Beta-4C DE adrenoreceptor). GN Name=ADRB4C; OS Meleagris gallopavo (Common turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Meleagris. OX NCBI_TaxID=9103; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=95014249; PubMed=7929160; RA Chen X.-H., Harden T.K., Nicholas R.A.; RT "Molecular cloning and characterization of a novel beta-adrenergic RT receptor."; RL J. Biol. Chem. 269:24810-24819(1994). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Broad tissue distribution. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U13977; AAA62150.1; -; mRNA. DR EMBL; U13978; AAA62151.1; -; Genomic_DNA. DR PIR; A55044; A55044. DR InterPro; IPR000507; Adrgc_rcpt_B1. DR InterPro; IPR000681; Adrgc_rcpt_B3. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF55; Adrgc_receptorB3; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00561; ADRENRGCB1AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 428 Beta-4C adrenergic receptor. FT /FTId=PRO_0000069111. FT TOPO_DOM 1 25 Extracellular (Potential). FT TRANSMEM 26 49 1 (Potential). FT TOPO_DOM 50 58 Cytoplasmic (Potential). FT TRANSMEM 59 77 2 (Potential). FT TOPO_DOM 78 97 Extracellular (Potential). FT TRANSMEM 98 119 3 (Potential). FT TOPO_DOM 120 141 Cytoplasmic (Potential). FT TRANSMEM 142 164 4 (Potential). FT TOPO_DOM 165 189 Extracellular (Potential). FT TRANSMEM 190 211 5 (Potential). FT TOPO_DOM 212 261 Cytoplasmic (Potential). FT TRANSMEM 262 283 6 (Potential). FT TOPO_DOM 284 294 Extracellular (Potential). FT TRANSMEM 295 315 7 (Potential). FT TOPO_DOM 316 428 Cytoplasmic (Potential). FT LIPID 329 329 S-palmitoyl cysteine (By similarity). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT DISULFID 96 175 By similarity. SQ SEQUENCE 428 AA; 47398 MW; E82DC920BE3B6889 CRC64; MTPLPAGNGS VPNCSWAAVL SRQWAVGAAL SITILVIVAG NLLVIVAIAK TPRLQTMTNV FVTSLACADL VMGLLVVPPG ATILLSGHWP YGTVVCELWT SLDVLCVTAS IETLCAIAVD RYLAITAPLQ YEALVTKGRA WAVVCMVWAI SAFISFLPIM NHWWRDGADE QAVRCYDDPR CCDFVTNMTY AIVSSTVSFY VPLLVMIFVY VRVFAVATRH VQLIGKDKVR FLQENPSLSS RGGRWRRPSR LLAIKEHKAL KTLGIIMGTF TLCWLPFFVA NIIKVFCRPL VPDQLFLFLN WLGYVNSAFN PIIYCRSPDF RSAFRKLLCC PRRADRRLHA APQDPQHCSC AFSPRGDPME DSKAVDPGHL REDSEVQGSG RREENASSHG GGHQQRPLGE CWLQGMQSML CEQLDEFTST EMPAGPSV // ID ADRB2_CANFA STANDARD; PRT; 415 AA. AC P54833; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 02-MAY-2006, entry version 43. DE Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2 DE adrenoreceptor). GN Name=ADRB2; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Heart muscle; RX MEDLINE=97034778; PubMed=8880434; RA Emala C.W., Kuhl J., Hirshman C.A., Levine M.A.; RT "Rapid communication: cloning and sequencing of a canine beta 2- RT adrenergic receptor cDNA."; RL J. Anim. Sci. 74:2285-2286(1996). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97364078; PubMed=9220370; RA Huang R.-R.C., Rapoport D., Schaeffer M.-T., Cascieri M.A., Fong T.M.; RT "Molecular cloning of the dog beta 1 and beta 2 adrenergic RT receptors."; RL J. Recept. Signal Transduct. Res. 17:599-607(1997). CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine- CC induced activation of adenylate cyclase through the action of G CC proteins. The beta-2-adrenergic receptor binds epinephrine with an CC approximately 30-fold greater affinity than it does CC norepinephrine. CC -!- SUBUNIT: Binds SLC9A3R1 (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Palmitoylated; may reduce accessibility of Ser-345 and Ser- CC 346 by anchoring Cys-341 to the plasma membrane. Agonist CC stimulation promotes depalmitoylation and further allows Ser-345 CC and Ser-346 phosphorylation (By similarity). CC -!- PTM: Phosphorylated by PKA and BARK; mediate homologous CC desensitization of the receptor. PKA-mediated phosphorylation CC seems to facilitate phosphorylation by BARK (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X94608; CAA64316.1; -; mRNA. DR EMBL; U73206; AAB93647.1; -; Genomic_DNA. DR UniGene; Cfa.3770; -. DR Ensembl; ENSCAFG00000018339; Canis familiaris. DR InterPro; IPR000332; Adrgc_rcpt_B2. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF57; Adrgc_receptorB2; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00562; ADRENRGCB2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 415 Beta-2 adrenergic receptor. FT /FTId=PRO_0000069128. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 58 1 (Potential). FT TOPO_DOM 59 71 Cytoplasmic (Potential). FT TRANSMEM 72 95 2 (Potential). FT TOPO_DOM 96 106 Extracellular (Potential). FT TRANSMEM 107 129 3 (Potential). FT TOPO_DOM 130 150 Cytoplasmic (Potential). FT TRANSMEM 151 174 4 (Potential). FT TOPO_DOM 175 196 Extracellular (Potential). FT TRANSMEM 197 220 5 (Potential). FT TOPO_DOM 221 274 Cytoplasmic (Potential). FT TRANSMEM 275 298 6 (Potential). FT TOPO_DOM 299 305 Extracellular (Potential). FT TRANSMEM 306 329 7 (Potential). FT TOPO_DOM 330 415 Cytoplasmic (Potential). FT SITE 113 113 Implicated in catechol agonist and FT antagonist binding (By similarity). FT SITE 204 204 Implicated in catechol agonist binding FT (By similarity). FT SITE 207 207 Implicated in catechol agonist binding FT (By similarity). FT MOD_RES 261 261 Phosphoserine (by PKA) (Potential). FT MOD_RES 262 262 Phosphoserine (by PKA) (Potential). FT MOD_RES 345 345 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 346 346 Phosphoserine (by PKA) (upon agonist FT stimulation) (By similarity). FT MOD_RES 355 355 Phosphoserine (by BARK) (Probable). FT LIPID 341 341 S-palmitoyl cysteine. FT CARBOHYD 6 6 N-linked (GlcNAc...) (Probable). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Probable). FT DISULFID 106 184 By similarity. SQ SEQUENCE 415 AA; 46589 MW; 392588623833445E CRC64; MGQPANRSVF LLAPNGSHAP DQGDSQERSE AWVVGMGIVM SLIVLAIVFG NVLVITAIAR FERLQTVTNY FITSLACADL VMGLAVVPFG ASHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVVILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYAKETC CDFFTNQAYA IASSIVSFYL PLVVMVFVYS RVFQVAQRQL QKIDRSEGRF HAQNLSQVEQ DGRSGHGHRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD NLIPKEVYIL LNWVGYVNSA FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSNNSNS RSDYAGEHSG CHLGQEKDSE LLCEDPPGTE DRQGTVPSDS VDSQGRNCST NDSLL // ID DRD1L_OREMO STANDARD; PRT; 386 AA. AC P47800; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 07-MAR-2006, entry version 37. DE D(1)-like dopamine receptor. OS Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Labroidei; OC Cichlidae; African cichlids; Pseudocrenilabrinae; Tilapiini; OC Oreochromis. OX NCBI_TaxID=8127; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=96328259; PubMed=8765745; DOI=10.1016/0167-4781(96)00086-3; RA Lamers A.E., Groneveld D., de Kleijn D.P.V., Ceeraedts F.C.G., RA Leunissen J.A.M., Flik G., Wendelaar Bonga S.E., Martens G.J.M.; RT "Cloning and sequence analysis of a hypothalamic cDNA encoding a D1c RT dopamine receptor in tilapia."; RL Biochim. Biophys. Acta 1308:17-22(1996). CC -!- FUNCTION: This is one of the five types (D1 to D5) of receptors CC for dopamine. The activity of this receptor is mediated by G CC proteins which activate adenylyl cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X81969; CAA57494.1; -; mRNA. DR PIR; S72168; S72168. DR HSSP; P08913; 1HLL. DR InterPro; IPR000929; Dopamine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 386 D(1)-like dopamine receptor. FT /FTId=PRO_0000069383. FT TOPO_DOM 1 35 Extracellular (Potential). FT TRANSMEM 36 56 1 (Potential). FT TOPO_DOM 57 72 Cytoplasmic (Potential). FT TRANSMEM 73 92 2 (Potential). FT TOPO_DOM 93 109 Extracellular (Potential). FT TRANSMEM 110 131 3 (Potential). FT TOPO_DOM 132 150 Cytoplasmic (Potential). FT TRANSMEM 151 175 4 (Potential). FT TOPO_DOM 176 195 Extracellular (Potential). FT TRANSMEM 196 220 5 (Potential). FT TOPO_DOM 221 266 Cytoplasmic (Potential). FT TRANSMEM 267 292 6 (Potential). FT TOPO_DOM 293 305 Extracellular (Potential). FT TRANSMEM 306 325 7 (Potential). FT TOPO_DOM 326 386 Cytoplasmic (Potential). FT CARBOHYD 189 189 N-linked (GlcNAc...) (Potential). FT CARBOHYD 193 193 N-linked (GlcNAc...) (Potential). FT DISULFID 108 188 By similarity. SQ SEQUENCE 386 AA; 42732 MW; FF9560396BD20756 CRC64; MEIFTTTRGT SAGPEPAPGG HGGTDSPRTS DLSLRALTGC VLCILIVSTL LGNALVCAAV IKFRHLRSKV TNAFVISLAV SDLFVAVLVM PWRAVSEVAG VWLFGAFCDT WVAFDIMCST ASILHLCIIS MDRYWAISSP FRYERRMTPR FGCVMIGVAW TLSVLISFIP VQLNWHARGR ERTDPGDCNA SLNRTYAISS SLISFYIPVL IMVGTYTRIF RIGRTQIRRI SSLERAAPRA TRGPALCDEE SSLKTSFRRE TKVLKTLSVI MGVFVFCWLP FFVLNCMVPF CRLEPAAAPC VSDTTFSVFV WFGWANSSLN PVIYAFNADF RKAFSTILGC SRYCRTSAVE AVDFSNELAS YHHDTTLQKE ASSRGNSRGG PYQFAL // ID DRD1_CARAU STANDARD; PRT; 363 AA. AC P35406; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 1. DT 07-MAR-2006, entry version 37. DE D(1) dopamine receptor. OS Carassius auratus (Goldfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Carassius. OX NCBI_TaxID=7957; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Retina; RX MEDLINE=94088471; PubMed=8264547; RA Frail D.E., Manelli A.M., Witte D.G., Lin C.W., Steffey M.E., RA MacKenzie R.G.; RT "Cloning and characterization of a truncated dopamine D1 receptor from RT goldfish retina: stimulation of cyclic AMP production and calcium RT mobilization."; RL Mol. Pharmacol. 44:1113-1118(1993). CC -!- FUNCTION: This is one of the five types (D1 to D5) of receptors CC for dopamine. the activity of this receptor is mediated by G CC proteins which activate adenylyl cyclase. Could be involved in CC growth hormone release. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Retina. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L08602; AAA16322.1; -; Unassigned_DNA. DR PIR; I50475; I50475. DR HSSP; P08913; 1HLL. DR InterPro; IPR000929; Dopamine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 363 D(1) dopamine receptor. FT /FTId=PRO_0000069379. FT TOPO_DOM 1 24 Extracellular (Potential). FT TRANSMEM 25 45 1 (Potential). FT TOPO_DOM 46 61 Cytoplasmic (Potential). FT TRANSMEM 62 81 2 (Potential). FT TOPO_DOM 82 98 Extracellular (Potential). FT TRANSMEM 99 120 3 (Potential). FT TOPO_DOM 121 139 Cytoplasmic (Potential). FT TRANSMEM 140 164 4 (Potential). FT TOPO_DOM 165 194 Extracellular (Potential). FT TRANSMEM 195 219 5 (Potential). FT TOPO_DOM 220 271 Cytoplasmic (Potential). FT TRANSMEM 272 297 6 (Potential). FT TOPO_DOM 298 310 Extracellular (Potential). FT TRANSMEM 311 330 7 (Potential). FT TOPO_DOM 331 363 Cytoplasmic (Potential). FT LIPID 345 345 S-palmitoyl cysteine (By similarity). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT DISULFID 97 187 By similarity. SQ SEQUENCE 363 AA; 40652 MW; 4B47FDE240D65DD0 CRC64; MAVLDLNLTT VIDSGFMESD RSVRVLTGCF LSVLILSTLL GNTLVCAAVT KFRHLRSKVT NFFVISLAVS DLLVAVLVMP WKAVTEVAGF WPFGAFCDIW VAFDIMCSTA SILNLCVISV DRYWAISSPF RYERKMTPRV AFVMISGAWT LSVLISFIPV QLKWHKAQPI GFLEVNASRR DLPTDNCDSS LNRTYAISSS LISFYIPVAI MIVTYTQIYR IAQKQIRRIS ALERAAESAQ IRHDSMGSGS NMDLESSFKL SFKRETKVLK TLSVIMGVFV CCWLPFFILN CMVPFCKRTS NGLPCISPTT FDVFVWFGWA NSSLNPIIYA FNADFRRAFA ILLGCQRLCP GSISMETPSL NKN // ID DRD5_XENLA STANDARD; PRT; 457 AA. AC P42290; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 07-MAR-2006, entry version 36. DE D(1B) dopamine receptor (D(5) dopamine receptor). OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=95024150; PubMed=7937989; RA Sugamori K.S., Demchyshyn L.L., Chung M., Niznik H.B.; RT "D1A, D1B, and D1C dopamine receptors from Xenopus laevis."; RL Proc. Natl. Acad. Sci. U.S.A. 91:10536-10540(1994). CC -!- FUNCTION: This is one of the five types (D1 to D5) of receptors CC for dopamine. The activity of this receptor is mediated by G CC proteins which activate adenylyl cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain and kidney. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U07864; AAA50829.1; -; Genomic_DNA. DR PIR; I51660; I51660. DR HSSP; P08913; 1HLL. DR InterPro; IPR000497; Dopa_1B_rcpt. DR InterPro; IPR000929; Dopamine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00566; DOPAMINED1BR. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 457 D(1B) dopamine receptor. FT /FTId=PRO_0000069410. FT TOPO_DOM 1 41 Extracellular (Potential). FT TRANSMEM 42 67 1 (Potential). FT TOPO_DOM 68 78 Cytoplasmic (Potential). FT TRANSMEM 79 105 2 (Potential). FT TOPO_DOM 106 114 Extracellular (Potential). FT TRANSMEM 115 137 3 (Potential). FT TOPO_DOM 138 156 Cytoplasmic (Potential). FT TRANSMEM 157 181 4 (Potential). FT TOPO_DOM 182 205 Extracellular (Potential). FT TRANSMEM 206 231 5 (Potential). FT TOPO_DOM 232 282 Cytoplasmic (Potential). FT TRANSMEM 283 309 6 (Potential). FT TOPO_DOM 310 326 Extracellular (Potential). FT TRANSMEM 327 351 7 (Potential). FT TOPO_DOM 352 457 Cytoplasmic (Potential). FT LIPID 361 361 S-palmitoyl cysteine (By similarity). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT DISULFID 114 199 By similarity. SQ SEQUENCE 457 AA; 51657 MW; A0A389311E4CD2FB CRC64; MYQPFQHLDS DQVASWQSPE MLMNKSVSRE SQRRKELVAG QIVTGSLLLL LIFWTLFGNI LVCTAVMRFR HLRSRVTNIF IVSLAVSDLL VALLVMPWKA VAEVAGHWPF GAFCDIWVAF DIMCSTASIL NLCVISVDRY WAISSPFRYE RKMTQRVALL MISTAWALSV LISFIPVQLS WHKSETEDHL LSNHSTGNCD SSLNRTYAIS SSLISFYIPV AIMIVTYTRI YRIAQIQIKR ISTLERAAEH AQSCRSNRVD SCSRHHQTSL RTSIKKETKV LKTLSIIMGV FVCCWLPFFI LNCMVPFCDR SPGHPQAGLP CVSETTFDIF VWFGWANSSL NPIIYAFNAD FRKVFSSLLG CGHWCSTTPV ETVNISNELI SYNQDTLFHK DIVTAYVNMI PNVVDCIDDN EDAFDHMSQI SQTSANNELA TDSMCELDSE VDISLHKITP SMSNGIH // ID TAA7A_MOUSE STANDARD; PRT; 358 AA. AC Q5QD12; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 04-JAN-2005, sequence version 1. DT 18-APR-2006, entry version 17. DE Trace amine-associated receptor 7a. GN Name=Taar7a; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C57BL/6; RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010; RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., RA Hoener M.C.; RT "Trace amine-associated receptors form structurally and functionally RT distinct subfamilies of novel G protein-coupled receptors."; RL Genomics 85:372-385(2005). CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Trace amines are biogenic amines present in very low levels in CC mammalian tissues. Although some trace amines have clearly defined CC roles as neurotransmitters in invertebrates, the extent to which CC they function as true neurotransmitters in vertebrates has CC remained speculative. Trace amines are likely to be involved in a CC variety of physiological functions that have yet to be fully CC understood (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY702331; AAV70141.1; -; Genomic_DNA. DR UniGene; Mm.377238; -. DR Ensembl; ENSMUSG00000059340; Mus musculus. DR MGI; MGI:2685075; Taar7a. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR009132; Trace_amine_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 358 Trace amine-associated receptor 7a. FT /FTId=PRO_0000070162. FT TOPO_DOM 1 47 Extracellular (Potential). FT TRANSMEM 48 68 1 (Potential). FT TOPO_DOM 69 83 Cytoplasmic (Potential). FT TRANSMEM 84 104 2 (Potential). FT TOPO_DOM 105 121 Extracellular (Potential). FT TRANSMEM 122 143 3 (Potential). FT TOPO_DOM 144 166 Cytoplasmic (Potential). FT TRANSMEM 167 187 4 (Potential). FT TOPO_DOM 188 212 Extracellular (Potential). FT TRANSMEM 213 233 5 (Potential). FT TOPO_DOM 234 274 Cytoplasmic (Potential). FT TRANSMEM 275 295 6 (Potential). FT TOPO_DOM 296 309 Extracellular (Potential). FT TRANSMEM 310 333 7 (Potential). FT TOPO_DOM 334 358 Cytoplasmic (Potential). FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential). FT CARBOHYD 210 210 N-linked (GlcNAc...) (Potential). FT DISULFID 120 205 By similarity. SQ SEQUENCE 358 AA; 40368 MW; 96E9A0053C0EB707 CRC64; MDKLVDHFLS DQSRTMNEDL FSATSTELCY ENLNRSCVRS PYSPGPRLIL YAVFGFGAAL AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGLTV MPFSTVRSVE GCWYFGESYC KFHSCFEGSF CYSSIFHLCF ISVDRYIAVS DPLTYPTRFT ASVSGKCITF SWLLSIIYSF SLLYTGANEA GLEDLVSVLT CVGGCQIAVN QSWVFINFLL FLIPTLVMMT VYSKIFLIAK QQAQNIEKMS KQTARASESY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG FITPTYVYEI LVWIAYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRENS STTNLFPE // ID TAA8A_MOUSE STANDARD; PRT; 344 AA. AC Q5QD07; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 04-JAN-2005, sequence version 1. DT 18-APR-2006, entry version 18. DE Trace amine-associated receptor 8a. GN Name=Taar8a; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C57BL/6; RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010; RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., RA Hoener M.C.; RT "Trace amine-associated receptors form structurally and functionally RT distinct subfamilies of novel G protein-coupled receptors."; RL Genomics 85:372-385(2005). CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Trace amines are biogenic amines present in very low levels in CC mammalian tissues. Although some trace amines have clearly defined CC roles as neurotransmitters in invertebrates, the extent to which CC they function as true neurotransmitters in vertebrates has CC remained speculative. Trace amines are likely to be involved in a CC variety of physiological functions that have yet to be fully CC understood (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY702337; AAV70146.1; -; Genomic_DNA. DR UniGene; Mm.377239; -. DR Ensembl; ENSMUSG00000050804; Mus musculus. DR MGI; MGI:2685076; Taar8a. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR009132; Trace_amine_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 344 Trace amine-associated receptor 8a. FT /FTId=PRO_0000070175. FT TOPO_DOM 1 31 Extracellular (Potential). FT TRANSMEM 32 52 1 (Potential). FT TOPO_DOM 53 67 Cytoplasmic (Potential). FT TRANSMEM 68 88 2 (Potential). FT TOPO_DOM 89 111 Extracellular (Potential). FT TRANSMEM 112 132 3 (Potential). FT TOPO_DOM 133 146 Cytoplasmic (Potential). FT TRANSMEM 147 167 4 (Potential). FT TOPO_DOM 168 195 Extracellular (Potential). FT TRANSMEM 196 216 5 (Potential). FT TOPO_DOM 217 260 Cytoplasmic (Potential). FT TRANSMEM 261 281 6 (Potential). FT TOPO_DOM 282 282 Extracellular (Potential). FT TRANSMEM 283 303 7 (Potential). FT TOPO_DOM 304 344 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT DISULFID 104 189 By similarity. SQ SEQUENCE 344 AA; 37848 MW; F1A94890116107CA CRC64; MTSNFSQPAL QLCYENTNGS CIKTPYSPGP RVILYMVYGF GAVLAVCGNL LVVISVLHFK QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG DAFCSLHSCC DVAFCYSSVL HLCFISVDRY IAVTDPLVYP TKFTVSVSGI CISISWILPL VYSSAVFYTG ISAKGIESLV SALNCVGGCQ IVINQDFVLI SFLLFFIPTL VMIILYSKIF LVAKQQAVKI ETSVSGNRGE SSSESHKARV AKRERKAAKT LGVTVVAFMV SWLPYTIDAL VDAFMGFITP AYVYEICCWG TYYNSAMNPL IYAFFFPWFK KAIKLILSGE ILKGHSSTAN LFSE // ID TAAR2_MOUSE STANDARD; PRT; 339 AA. AC Q5QD17; Q80T53; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 04-JAN-2005, sequence version 1. DT 18-APR-2006, entry version 17. DE Trace amine-associated receptor 2 (G-protein coupled receptor 58). GN Name=Taar2; Synonyms=Gpr58; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/6; RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010; RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., RA Hoener M.C.; RT "Trace amine-associated receptors form structurally and functionally RT distinct subfamilies of novel G protein-coupled receptors."; RL Genomics 85:372-385(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-313. RX MEDLINE=22584407; PubMed=12679517; DOI=10.1073/pnas.0230374100; RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., RA Bergmann J.E., Gaitanaris G.A.; RT "The G protein-coupled receptor repertoires of human and mouse."; RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY702326; AAV70136.1; -; mRNA. DR EMBL; AY255589; AAO85101.1; -; mRNA. DR UniGene; Mm.300611; -. DR Ensembl; ENSMUSG00000059763; Mus musculus. DR MGI; MGI:2685071; Taar2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR009132; Trace_amine_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 339 Trace amine-associated receptor 2. FT /FTId=PRO_0000070147. FT TOPO_DOM 1 36 Extracellular (Potential). FT TRANSMEM 37 57 1 (Potential). FT TOPO_DOM 58 67 Cytoplasmic (Potential). FT TRANSMEM 68 88 2 (Potential). FT TOPO_DOM 89 106 Extracellular (Potential). FT TRANSMEM 107 127 3 (Potential). FT TOPO_DOM 128 150 Cytoplasmic (Potential). FT TRANSMEM 151 171 4 (Potential). FT TOPO_DOM 172 195 Extracellular (Potential). FT TRANSMEM 196 216 5 (Potential). FT TOPO_DOM 217 251 Cytoplasmic (Potential). FT TRANSMEM 252 272 6 (Potential). FT TOPO_DOM 273 287 Extracellular (Potential). FT TRANSMEM 288 310 7 (Potential). FT TOPO_DOM 311 339 Cytoplasmic (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 277 277 N-linked (GlcNAc...) (Potential). FT DISULFID 104 189 By similarity. SQ SEQUENCE 339 AA; 38517 MW; 8F38253A3C677B20 CRC64; MASFEAQQET FDCSEYGNGS CPENERSLGV RAAMYSLMAC AIFITIFGNL AMIISISYFK QLHTPTNLLI LSMAVTDFLL GFTIMPYSMV RSVENCWYFG LTFCKIHYSF DLMLSITSIF HLCSVAVDRF YAICHPLHYC TKMTIPVVRR LLLVCWSVPG AFAFGVVFSE AYADGIEGYD ILVACSSSCP VMFNKLWGTT LFVAGFFTPS SMMVGIYGKI FAVSKKHARV IDNLPENQNN QMRKDKKAAK TLGIVMGVFL LCWFPCFFTI LLDPFLNFST PAVLFDALTW FGYFNSTCNP LIYGFFYPWF RRALKYILLG KIFSSHFHNT NLFTQKETE // ID TAAR4_MOUSE STANDARD; PRT; 347 AA. AC Q5QD15; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 04-JAN-2005, sequence version 1. DT 18-APR-2006, entry version 18. DE Trace amine-associated receptor 4. GN Name=Taar4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=C57BL/6; RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010; RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., RA Hoener M.C.; RT "Trace amine-associated receptors form structurally and functionally RT distinct subfamilies of novel G protein-coupled receptors."; RL Genomics 85:372-385(2005). CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. CC Of the biogenic trace amine tested, activated only by beta- CC phenylethylamine (beta-PEA) and tryptamine; however, the response CC is of low potency. Trace amines are biogenic amines present in CC very low levels in mammalian tissues. Although some trace amines CC have clearly defined roles as neurotransmitters in invertebrates, CC the extent to which they function as true neurotransmitters in CC vertebrates has remained speculative. Trace amines are likely to CC be involved in a variety of physiological functions that have yet CC to be fully understood. This receptor seems to be mediated by the CC G(s)-class of G-proteins which activate adenylate cyclase (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY702328; AAV70138.1; -; Genomic_DNA. DR UniGene; Mm.300612; -. DR Ensembl; ENSMUSG00000069707; Mus musculus. DR MGI; MGI:2685072; Taar4. DR InterPro; IPR001520; 5HT4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR009132; Trace_amine_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01059; 5HT4RECEPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01830; TRACEAMINER. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Transducer; Transmembrane. FT CHAIN 1 347 Trace amine-associated receptor 4. FT /FTId=PRO_0000070152. FT TOPO_DOM 1 37 Extracellular (Potential). FT TRANSMEM 38 58 1 (Potential). FT TOPO_DOM 59 69 Cytoplasmic (Potential). FT TRANSMEM 70 90 2 (Potential). FT TOPO_DOM 91 110 Extracellular (Potential). FT TRANSMEM 111 129 3 (Potential). FT TOPO_DOM 130 149 Cytoplasmic (Potential). FT TRANSMEM 150 170 4 (Potential). FT TOPO_DOM 171 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT TOPO_DOM 219 260 Cytoplasmic (Potential). FT TRANSMEM 261 281 6 (Potential). FT TOPO_DOM 282 296 Extracellular (Potential). FT TRANSMEM 297 317 7 (Potential). FT TOPO_DOM 318 347 Cytoplasmic (Potential). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Potential). FT DISULFID 106 191 By similarity. SQ SEQUENCE 347 AA; 38904 MW; B1564F458416C9C0 CRC64; MNTPDPWSSP EVQFCFAAAN SSCPRKARPA LVVCAMYLIM IGAIVMTMLG NMAVIISIAH FKQLHSPTNF LILSMATTDF LLSCVVMPFS MIRSIESCWY FGDLFCKVHS CCDIMLCTTS IFHLCFISVD RHYAVCDPLH YVTQITTRVV GVFLLISWSV PIFFAFGLVF SELNLIGAED FVAAIDCTGL CVLIFNKLWG VLASFIAFFL PGTVMVGIYI HIFTVAQKHA RQIGTGPRTK QALSESKMKA TSKKESKATK TLSIVMGVFV LCWLPFFVLT ITDPFIDFTT PEDLYNVFLW LGYFNSTFNP IIYGMFYPWF RKALRMIVTG TIFRSDSSTS SLHPAHP // ID ADA1A_CAVPO STANDARD; PRT; 466 AA. AC Q9WU25; DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 2. DT 21-MAR-2006, entry version 37. DE Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A- DE adrenoreceptor) (Alpha-1C adrenergic receptor). GN Name=ADRA1A; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RX MEDLINE=21419075; PubMed=11527538; DOI=10.1016/S0014-2999(01)01217-1; RA Gonzalez-Espinosa C., Romero-Avila M.T., Mora-Rodriguez D.M., RA Gonzalez-Espinosa D., Garcia-Sainz J.A.; RT "Molecular cloning and functional expression of the guinea pig RT alpha(1a)-adrenoceptor."; RL Eur. J. Pharmacol. 426:147-155(2001). CC -!- FUNCTION: This alpha-adrenergic receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. Its effect is mediated by G(q) CC and G(11) proteins (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF108016; AAD22540.2; -; mRNA. DR InterPro; IPR001004; Adrene_rcpt_A1Cs. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF119; A_receptorA1Cs; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00557; ADRENRGCA1AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 466 Alpha-1A adrenergic receptor. FT /FTId=PRO_0000069062. FT TOPO_DOM 1 25 Extracellular (Potential). FT TRANSMEM 26 51 1 (Potential). FT TOPO_DOM 52 63 Cytoplasmic (Potential). FT TRANSMEM 64 89 2 (Potential). FT TOPO_DOM 90 99 Extracellular (Potential). FT TRANSMEM 100 122 3 (Potential). FT TOPO_DOM 123 143 Cytoplasmic (Potential). FT TRANSMEM 144 168 4 (Potential). FT TOPO_DOM 169 181 Extracellular (Potential). FT TRANSMEM 182 205 5 (Potential). FT TOPO_DOM 206 272 Cytoplasmic (Potential). FT TRANSMEM 273 297 6 (Potential). FT TOPO_DOM 298 304 Extracellular (Potential). FT TRANSMEM 305 329 7 (Potential). FT TOPO_DOM 330 466 Cytoplasmic (Potential). FT LIPID 345 345 S-palmitoyl cysteine (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 466 AA; 51578 MW; E0E27E4FF5D3D0CD CRC64; MVFLSGNASD SSNCTQPPAP VNIPKAILLG VILGVLILFG VPGNILVILS VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN IWAAVDVLCC TASIMSLCII SIDRYIGVSY PLRYPTIVTQ RRGLRALLCL WALSLVISIG PLFGWRQPAP QDETICQINE DPSYVLFSAL GSFYVPLAII LVMYCRVYVV AKRESRGLTS GLKTDKSDSE QVTLRIHRKN APLGGSGVAS SKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LKIQCLRRKQ SSKHALGYTL HPPSQAVEGQ HKDMVRIPVG SRETFYKISK TDGVCEWKFF SSMPRGSARI TVPKDQSACT TARVRSKSFL QVCCCVGPST PNPGENHQVP TIKIHTISLS ENGEEV // ID ADA1B_MOUSE STANDARD; PRT; 514 AA. AC P97717; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 2. DT 18-APR-2006, entry version 43. DE Alpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B- DE adrenoreceptor). GN Name=Adra1b; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/c; TISSUE=Brain; RA Cotecchia S., Lattion-Zellweger A.; RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 238-276. RX MEDLINE=96064818; PubMed=7595531; RA Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., RA Chinchetru M.A.; RT "Molecular cloning of alpha 1d-adrenergic receptor and tissue RT distribution of three alpha 1-adrenergic receptor subtypes in mouse."; RL J. Neurochem. 65:2387-2392(1995). CC -!- FUNCTION: This alpha-adrenergic receptor mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y12738; CAA73272.1; -; mRNA. DR EMBL; S80219; AAB47043.1; -; mRNA. DR UniGene; Mm.39086; -. DR HSSP; P29274; 1MMH. DR Ensembl; ENSMUSG00000050541; Mus musculus. DR MGI; MGI:104774; Adra1b. DR GO; GO:0000299; C:integral to membrane of membrane fraction; IDA. DR GO; GO:0004937; F:alpha1-adrenergic receptor activity; IDA. DR GO; GO:0007512; P:adult heart development; IGI. DR GO; GO:0048148; P:behavioral response to cocaine; IMP. DR GO; GO:0001974; P:blood vessel remodeling; IMP. DR GO; GO:0016049; P:cell growth; IGI. DR GO; GO:0042593; P:glucose homeostasis; IMP. DR GO; GO:0001997; P:increased strength of heart contraction by ...; IGI. DR GO; GO:0007626; P:locomotory behavior; IMP. DR GO; GO:0045818; P:negative regulation of glycogen catabolism; IMP. DR GO; GO:0035265; P:organ growth; IGI. DR GO; GO:0045819; P:positive regulation of glycogen catabolism; IMP. DR GO; GO:0001996; P:positive regulation of heart contraction ra...; IGI. DR GO; GO:0001975; P:response to amphetamine; IMP. DR GO; GO:0043278; P:response to morphine; IMP. DR GO; GO:0001987; P:vasoconstriction of artery during barorecep...; IMP. DR GO; GO:0008542; P:visual learning; IMP. DR InterPro; IPR001115; Adrene_rcpt_A1B. DR InterPro; IPR002233; Adrnrgc_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00556; ADRENRGCA1BR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 514 Alpha-1B adrenergic receptor. FT /FTId=PRO_0000069071. FT TOPO_DOM 1 45 Extracellular (Potential). FT TRANSMEM 46 69 1 (Potential). FT TOPO_DOM 70 82 Cytoplasmic (Potential). FT TRANSMEM 83 104 2 (Potential). FT TOPO_DOM 105 114 Extracellular (Potential). FT TRANSMEM 115 140 3 (Potential). FT TOPO_DOM 141 160 Cytoplasmic (Potential). FT TRANSMEM 161 181 4 (Potential). FT TOPO_DOM 182 200 Extracellular (Potential). FT TRANSMEM 201 223 5 (Potential). FT TOPO_DOM 224 294 Cytoplasmic (Potential). FT TRANSMEM 295 318 6 (Potential). FT TOPO_DOM 319 325 Extracellular (Potential). FT TRANSMEM 326 339 7 (Potential). FT TOPO_DOM 340 514 Cytoplasmic (Potential). FT COMPBIAS 370 377 Poly-Arg. FT LIPID 364 364 S-palmitoyl cysteine (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT CARBOHYD 34 34 N-linked (GlcNAc...) (Potential). FT DISULFID 117 194 By similarity. SQ SEQUENCE 514 AA; 56418 MW; 17CFD10123DC2B29 CRC64; MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGC LGAFILFAIV GNILVILSVA CNRHLRTPTN YFIVNLAIAD LLLSFTDLPF SATLEVLGYW VLGRIFCDIW AAVDVLCCTA SILSLCAISI DRYIGVRYSL QYPTLVTRRK AILALLSVWV LSTVISIGPL LGWKEPAPND DKECGVTEEP FYALFSSLGS FYIPLAVILV MYCRVYIVAK RTTKNLEAGV MKEMSNSKEL TLRIHSKNFH EDTLSSTKAK GHNPRSSIAV KLFKFSREKK AAKTLGIVVG MFILCWLPFF IALPLGSLFS TLKPPDAVFK VVFWLGYFNS CLNPIIYPCS SKEFKRAFMR ILGCQCRGGR RRRRRRRLGA CAYTYRPWTR GGSLERSQSR KDSLDDSGSC MSGSQRTLPS ASPSPGYLGR GTQPPVELCA FPEWKPGALL SLPEPPGRRG RLDSGPLFTF KLLGEPESPG TEGDASNGGC DTTTDLANGQ PGFKSNMPLA PGHF // ID 5HT2A_HUMAN STANDARD; PRT; 471 AA. AC P28223; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 2. DT 18-APR-2006, entry version 65. DE 5-hydroxytryptamine 2A receptor (5-HT-2A) (Serotonin receptor 2A) (5- DE HT-2). GN Name=HTR2A; Synonyms=HTR2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain stem; RX MEDLINE=92109767; PubMed=1722404; RA Saltzman A.G., Morse B., Whitman M.M., Ivanshchenko Y., Jaye M., RA Felder S.; RT "Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes."; RL Biochem. Biophys. Res. Commun. 181:1469-1478(1991). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92356792; PubMed=1323014; DOI=10.1016/0169-328X(92)90005-V; RA Chen K., Yang W., Grimsby J., Shih J.C.; RT "The human 5-HT2 receptor is encoded by a multiple intron-exon gene."; RL Brain Res. Mol. Brain Res. 14:20-26(1992). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94308772; PubMed=8035173; RA Cook E.H. Jr., Fletcher K.E., Wainwright M., Marks N., Yan S.Y., RA Leventhal B.L.; RT "Primary structure of the human platelet serotonin 5-HT2A receptor: RT identify with frontal cortex serotonin 5-HT2A receptor."; RL J. Neurochem. 63:465-469(1994). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [6] RP NUCLEOTIDE SEQUENCE OF 9-464. RC TISSUE=Brain; RA Tritch R.J., Robinson D.L., Sahagan B.G., Horlick R.A.; RT "Cloning and nucleotide sequence of the human(5HT) type 2 receptor."; RL Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE OF 105-218. RX MEDLINE=93049882; PubMed=1330647; DOI=10.1016/0922-4106(92)90123-D; RA Stam N.J., van Huizen F., van Alebeek C., Brands J., Dijkema R., RA Tonnaer J.A., Olijve W.; RT "Genomic organization, coding sequence and functional expression of RT human 5-HT2 and 5-HT1A receptor genes."; RL Eur. J. Pharmacol. 227:153-162(1992). RN [8] RP INTERACTION WITH MPDZ. RX MEDLINE=21201137; PubMed=11150294; DOI=10.1074/jbc.M008089200; RA Becamel C., Figge A., Poliak S., Dumuis A., Peles E., Bockaert J., RA Luebbert H., Ullmer C.; RT "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with RT PDZ10 of the multi-PDZ domain protein MUPP1."; RL J. Biol. Chem. 276:12974-12982(2001). RN [9] RP INTERACTIONS WITH INADL; MPP3; PRDX6; DLG4; DLG1; CASK; APBA1 AND RP AIP1, AND MUTAGENESIS OF GLY-463; ASN-465; CYS-470 AND VAL-471. RX PubMed=14988405; DOI=10.1074/jbc.M312106200; RA Becamel C., Gavarini S., Chanrion B., Alonso G., Galeotti N., RA Dumuis A., Bockaert J., Marin P.; RT "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets RT of PDZ proteins."; RL J. Biol. Chem. 279:20257-20266(2004). RN [10] RP VARIANTS ASN-25 AND TYR-452. RX MEDLINE=96209907; PubMed=8655141; DOI=10.1007/s004390050104; RA Erdmann J., Shimron-Abarbanell D., Rietschel M., Albus M., Maier W., RA Koerner J., Bondy B., Chen K., Shih J.C., Knapp M., Propping P., RA Noethen M.M.; RT "Systematic screening for mutations in the human serotonin-2A (5-HT2A) RT receptor gene: identification of two naturally occurring receptor RT variants and association analysis in schizophrenia."; RL Hum. Genet. 97:614-619(1996). RN [11] RP VARIANTS ASN-25 AND TYR-452. RX MEDLINE=20049881; PubMed=10581480; RX DOI=10.1002/(SICI)1096-8628(19991215)88:6<621::AID-AJMG9>3.0.CO;2-H; RA Marshall S.E., Bird T.G., Hart K., Welsh K.I.; RT "Unified approach to the analysis of genetic variation in serotonergic RT pathways."; RL Am. J. Med. Genet. 88:621-627(1999). RN [12] RP VARIANTS VAL-197; VAL-447 AND TYR-452. RX MEDLINE=99318093; PubMed=10391209; DOI=10.1038/10290; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [13] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. This receptor CC mediates its action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. This CC receptor is involved in tracheal smooth muscle contraction, CC bronchoconstriction, and control of aldosterone production. CC -!- SUBUNIT: Interacts with MPDZ and INADL. May interact with MPP3, CC PRDX6, DLG4, DLG1, CASK, APBA1 and AIP1. CC -!- SUBCELLULAR LOCATION: Cell membrane; multi-pass membrane protein. CC Localizes to the post-synaptic thickening of axo-dendritic CC synapses (By similarity). CC -!- DOMAIN: The PDZ domain-binding motif is involved in the CC interaction with INADL, CASK, APBA1, DLG1 and DLG4. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; S42168; AAB22791.2; -; Genomic_DNA. DR EMBL; S42165; AAB22791.2; JOINED; Genomic_DNA. DR EMBL; S42167; AAB22791.2; JOINED; Genomic_DNA. DR EMBL; X57830; CAA40963.1; -; mRNA. DR EMBL; S71229; AAB31320.1; -; mRNA. DR EMBL; AF498982; AAM21129.1; -; mRNA. DR EMBL; BC069356; AAH69356.1; -; mRNA. DR EMBL; BC069576; AAH69576.1; -; mRNA. DR EMBL; BC074848; AAH74848.1; -; mRNA. DR EMBL; BC074849; AAH74849.1; -; mRNA. DR EMBL; M86841; AAA58354.1; -; mRNA. DR EMBL; S50130; AAB24166.2; -; Genomic_DNA. DR EMBL; S49737; AAB24166.2; JOINED; Genomic_DNA. DR EMBL; S50113; AAB24166.2; JOINED; Genomic_DNA. DR PIR; A43956; A43956. DR UniGene; Hs.424980; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSG00000102468; Homo sapiens. DR HGNC; HGNC:5293; HTR2A. DR MIM; 182135; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007210; P:serotonin receptor signaling pathway; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR000455; 5HT2A_rcpt. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF63; 5HT2A_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00516; 5HT2ARECEPTR. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 471 5-hydroxytryptamine 2A receptor. FT /FTId=PRO_0000068946. FT TOPO_DOM 1 75 Extracellular (Potential). FT TRANSMEM 76 99 1 (Potential). FT TOPO_DOM 100 110 Cytoplasmic (Potential). FT TRANSMEM 111 132 2 (Potential). FT TOPO_DOM 133 147 Extracellular (Potential). FT TRANSMEM 148 171 3 (Potential). FT TOPO_DOM 172 191 Cytoplasmic (Potential). FT TRANSMEM 192 215 4 (Potential). FT TOPO_DOM 216 233 Extracellular (Potential). FT TRANSMEM 234 254 5 (Potential). FT TOPO_DOM 255 324 Cytoplasmic (Potential). FT TRANSMEM 325 346 6 (Potential). FT TOPO_DOM 347 362 Extracellular (Potential). FT TRANSMEM 363 384 7 (Potential). FT TOPO_DOM 385 471 Cytoplasmic (Potential). FT MOTIF 469 471 PDZ-binding. FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). FT CARBOHYD 44 44 N-linked (GlcNAc...) (Potential). FT CARBOHYD 51 51 N-linked (GlcNAc...) (Potential). FT CARBOHYD 54 54 N-linked (GlcNAc...) (Potential). FT DISULFID 148 227 By similarity. FT VARIANT 25 25 T -> N (in dbSNP:1805055). FT /FTId=VAR_003448. FT VARIANT 197 197 I -> V (in dbSNP:6304). FT /FTId=VAR_013901. FT VARIANT 447 447 A -> V (in dbSNP:6308). FT /FTId=VAR_013902. FT VARIANT 452 452 H -> Y (in dbSNP:6314). FT /FTId=VAR_003449. FT MUTAGEN 463 463 G->V: Loss of interaction with INADL. FT MUTAGEN 465 465 N->S: No effect on interaction with FT INADL. Acquires the binding properties of FT HTR2C; when associated with S-470. FT MUTAGEN 470 470 C->S: No effect on interaction with FT INADL. Acquires the binding properties of FT HTR2C; when associated with S-465. FT MUTAGEN 471 471 V->A: Loss of interaction with INADL, FT CASK, APBA1, DLG1 and DLG4. SQ SEQUENCE 471 AA; 52603 MW; EF8AAC0BC5379DA2 CRC64; MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK QHSEEASKDN SDGVNEKVSC V // ID 5HT2B_MOUSE STANDARD; PRT; 479 AA. AC Q02152; Q8JZK5; Q9QWS2; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 21-JUN-2005, sequence version 2. DT 02-MAY-2006, entry version 54. DE 5-hydroxytryptamine 2B receptor (5-HT-2B) (Serotonin receptor 2B) (5- DE HT-2F) (NP75 protein). GN Name=Htr2b; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=93050195; PubMed=1426253; DOI=10.1016/0014-5793(92)80936-B; RA Loric S., Launay J.-M., Colas J.-F., Maroteaux L.; RT "New mouse 5-HT2-like receptor. Expression in brain, heart and RT intestine."; RL FEBS Lett. 312:203-207(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; RA Choi D.S., Maroteaux L.; RT "Genomic sequence of the 5-HT2B receptor locus."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=ILS, and ISS; RX MEDLINE=21363810; PubMed=11471062; DOI=10.1007/s00335-001-1001-x; RA Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., RA Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.; RT "High-throughput sequence identification of gene coding variants RT within alcohol-related QTLs."; RL Mamm. Genome 12:657-663(2001). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Cecum; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary tumor; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. This receptor CC mediates its action by association with G proteins that activate a CC phosphatidylinositol-calcium second messenger system. CC -!- SUBUNIT: Interacts with MPDZ (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Intestine and heart, but also in brain and CC kidney. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- CAUTION: Ref.1 sequence differs from that shown due to a Leu codon CC in position 480 which was translated as a stop codon to shorten CC the sequence. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Z15119; CAA78824.1; ALT_SEQ; mRNA. DR EMBL; AJ012488; CAA10051.1; -; Genomic_DNA. DR EMBL; AF498254; AAM22971.1; -; mRNA. DR EMBL; AF498255; AAM22972.1; -; mRNA. DR EMBL; AK033713; BAC28441.1; -; mRNA. DR EMBL; BC023690; AAH23690.1; -; mRNA. DR PIR; S27269; S27269. DR UniGene; Mm.280013; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSMUSG00000026228; Mus musculus. DR MGI; MGI:109323; Htr2b. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007507; P:heart development; IMP. DR GO; GO:0007208; P:serotonin receptor, phospholipase C activat...; TAS. DR InterPro; IPR000482; 5HT2B_rcpt. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR PANTHER; PTHR19266:SF61; 5HT2B_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00651; 5HT2BRECEPTR. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 479 5-hydroxytryptamine 2B receptor. FT /FTId=PRO_0000068954. FT TOPO_DOM 1 55 Extracellular (Potential). FT TRANSMEM 56 78 1 (Potential). FT TOPO_DOM 79 90 Cytoplasmic (Potential). FT TRANSMEM 91 112 2 (Potential). FT TOPO_DOM 113 128 Extracellular (Potential). FT TRANSMEM 129 150 3 (Potential). FT TOPO_DOM 151 170 Cytoplasmic (Potential). FT TRANSMEM 171 191 4 (Potential). FT TOPO_DOM 192 215 Extracellular (Potential). FT TRANSMEM 216 238 5 (Potential). FT TOPO_DOM 239 323 Cytoplasmic (Potential). FT TRANSMEM 324 344 6 (Potential). FT TOPO_DOM 345 359 Extracellular (Potential). FT TRANSMEM 360 382 7 (Potential). FT TOPO_DOM 383 479 Cytoplasmic (Potential). FT MOTIF 477 479 PDZ-binding. FT LIPID 396 396 S-palmitoyl cysteine (Potential). FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential). FT DISULFID 127 206 By similarity. FT CONFLICT 167 167 S -> T (in Ref. 1). FT CONFLICT 227 227 V -> A (in Ref. 3, 4 and 5). FT CONFLICT 449 449 S -> C (in Ref. 1). SQ SEQUENCE 479 AA; 53625 MW; FDB030D809079B6D CRC64; MASSYKMSEQ STTSEHILQK TCDHLILTNR SGLETDSVAE EMKQTVEGQG HTVHWAALLI LAVIIPTIGG NILVILAVAL EKRLQYATNY FLMSLAIADL LVGLFVMPIA LLTIMFEAIW PLPLALCPAW LFLDVLFSTA SIMHLCAISL DRYIAIKKPI QANQCNSRAT AFIKITVVWL ISIGIAIPVP IKGIETDVIN PHNVTCELTK DRFGSFMVFG SLAAFFVPLT IMVVTYFLTI HTLQKKAYLV KNKPPQRLTR WTVPTVFLRE DSSFSSPEKV AMLDGSHRDK ILPNSSDETL MRRMSSVGKR SAQTISNEQR ASKALGVVFF LFLLMWCPFF ITNLTLALCD SCNQTTLKTL LEIFVWIGYV SSGVNPLIYT LFNKTFREAF GRYITCNYRA TKSVKALRKF SSTLCFGNSM VENSKFFTKH GIRNGINPAM YQSPMRLRSS TIQSSSIILL DTLLTENDGD KAEEQVSYI // ID HRH1_CAVPO STANDARD; PRT; 488 AA. AC P31389; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 07-MAR-2006, entry version 43. DE Histamine H1 receptor. GN Name=HRH1; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Hartley; TISSUE=Liver; RX MEDLINE=94110266; PubMed=8282735; RA Horio Y., Mori Y., Higuchi I., Fujimoto K., Ito S., Fukui H.; RT "Molecular cloning of the guinea-pig histamine H1 receptor gene."; RL J. Biochem. 114:408-414(1993). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=94125094; PubMed=8294913; RA Traiffort E., Leurs R., Arrang J.-M., Tardivel-Lacombe J., Diaz J., RA Schwartz J.C., Ruat M.; RT "Guinea pig histamine H1 receptor. I. Gene cloning, characterization, RT and tissue expression revealed by in situ hybridization."; RL J. Neurochem. 62:507-518(1994). CC -!- FUNCTION: In peripheral tissues, the H1 subclass of histamine CC receptors mediates the contraction of smooth muscles, increase in CC capillary permeability due to contraction of terminal venules, and CC catecholamine release from adrenal medulla, as well as mediating CC neurotransmission in the central nervous system. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Potential sites of phosphorylation in the third cytoplasmic CC loop may play an important role in regulating signal transduction CC through the receptor molecule. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; D15074; BAA03669.1; -; Genomic_DNA. DR EMBL; S68706; AAC60674.1; -; Genomic_DNA. DR PIR; I56507; I56507. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000921; H1_rcpt. DR PANTHER; PTHR19266:SF77; H1_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00530; HISTAMINEH1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane. FT CHAIN 1 488 Histamine H1 receptor. FT /FTId=PRO_0000069674. FT TOPO_DOM 1 38 Extracellular (Potential). FT TRANSMEM 39 58 1 (Potential). FT TOPO_DOM 59 72 Cytoplasmic (Potential). FT TRANSMEM 73 92 2 (Potential). FT TOPO_DOM 93 110 Extracellular (Potential). FT TRANSMEM 111 132 3 (Potential). FT TOPO_DOM 133 154 Cytoplasmic (Potential). FT TRANSMEM 155 174 4 (Potential). FT TOPO_DOM 175 198 Extracellular (Potential). FT TRANSMEM 199 219 5 (Potential). FT TOPO_DOM 220 419 Cytoplasmic (Potential). FT TRANSMEM 420 439 6 (Potential). FT TOPO_DOM 440 451 Extracellular (Potential). FT TRANSMEM 452 471 7 (Potential). FT TOPO_DOM 472 488 Cytoplasmic (Potential). FT LIPID 445 445 S-palmitoyl cysteine (Potential). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT CARBOHYD 27 27 N-linked (GlcNAc...) (Potential). FT DISULFID 109 189 By similarity. SQ SEQUENCE 488 AA; 55620 MW; 7E58C681E1A2178E CRC64; MSFLPGMTPV TLSNFSWALE DRMLEGNSTT TPTRQLMPLV VVLSSVSLVT VALNLLVLYA VRSERKLHTV GNLYIVSLSV ADLIVGAVVM PMSILYLHRS AWILGRPLCL FWLSMDYVAS TASIFSVFIL CIDRYRSVQQ PLRYLRYRTK TRASATILGA WLLSFLWVIP ILGWHHFMAP TSEPREKKCE TDFYDVTWFK VMTAIINFYL PTLLMLWFYI RIYKAVRRHC QHRQLINSSL PSFSEMKLKL ENAKVDTRRM GKESPWEDPK RCSKDASGVH TPMPSSQHLV DMPCAAVLSE DEGGEVGTRQ MPMLAVGDGR CCEALNHMHS QLELSGQSRA THSISARPEE WTVVDGQSFP ITDSDTSTEA APMGGQPRSG SNSGLDYIKF TWRRLRSHSR QYTSGLHLNR ERKAAKQLGC IMAAFILCWI PYFVFFMVIA FCKSCSNEPV HMFTIWLGYL NSTLNPLIYP LCNENFRKTF KRILRIPP // ID ACM5_HUMAN STANDARD; PRT; 532 AA. AC P08912; Q96RG7; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 2. DT 18-APR-2006, entry version 65. DE Muscarinic acetylcholine receptor M5. GN Name=CHRM5; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=90166521; PubMed=3272174; DOI=10.1016/0896-6273(88)90190-0; RA Bonner T.I., Young A.C., Brann M.R., Buckley N.J.; RT "Cloning and expression of the human and rat m5 muscarinic RT acetylcholine receptor genes."; RL Neuron 1:403-410(1988). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Lens epithelium; RA Rae J.L., Shepard A.R.; RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RA Wang H., Yeomans J.; RT "Human muscarinic acetylcholine receptor 5 is localized on 15q13.1 and RT its expression in SH-SY5Y cells."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE OF 1-526. RC TISSUE=Keratinocyte; RA Arredondo J., Grando S.A.; RT "Cloning cholinergic receptors in human keratinocytes."; RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is Pi turnover. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M80333; AAA51569.1; -; Genomic_DNA. DR EMBL; AF026263; AAB95158.1; -; mRNA. DR EMBL; AB084282; BAB91222.1; -; mRNA. DR EMBL; AF498919; AAM18942.1; -; mRNA. DR EMBL; AF385591; AAK68116.1; -; mRNA. DR UniGene; Hs.584747; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSG00000184984; Homo sapiens. DR HGNC; HGNC:1954; CHRM5. DR MIM; 118496; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004981; F:muscarinic acetylcholine receptor activity; TAS. DR GO; GO:0004435; F:phosphoinositide phospholipase C activity; TAS. DR GO; GO:0007213; P:acetylcholine receptor signaling, muscarini...; TAS. DR GO; GO:0008283; P:cell proliferation; TAS. DR GO; GO:0007197; P:muscarinic acetylcholine receptor, adenylat...; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000502; Musac_M5_rcpt. DR InterPro; IPR000995; Musac_rcpt. DR PANTHER; PTHR19266:SF88; M5_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PRINTS; PR00542; MUSCRINICM5R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphorylation; KW Postsynaptic membrane; Receptor; Transducer; Transmembrane. FT CHAIN 1 532 Muscarinic acetylcholine receptor M5. FT /FTId=PRO_0000069042. FT TOPO_DOM 1 29 Extracellular (Potential). FT TRANSMEM 30 53 1 (Potential). FT TOPO_DOM 54 66 Cytoplasmic (Potential). FT TRANSMEM 67 87 2 (Potential). FT TOPO_DOM 88 104 Extracellular (Potential). FT TRANSMEM 105 126 3 (Potential). FT TOPO_DOM 127 146 Cytoplasmic (Potential). FT TRANSMEM 147 169 4 (Potential). FT TOPO_DOM 170 191 Extracellular (Potential). FT TRANSMEM 192 214 5 (Potential). FT TOPO_DOM 215 443 Cytoplasmic (Potential). FT TRANSMEM 444 464 6 (Potential). FT TOPO_DOM 465 478 Extracellular (Potential). FT TRANSMEM 479 498 7 (Potential). FT TOPO_DOM 499 532 Cytoplasmic (Potential). FT MOD_RES 501 501 Phosphothreonine (Potential). FT MOD_RES 505 505 Phosphothreonine (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT DISULFID 103 183 By similarity. FT CONFLICT 526 526 Q -> P (in Ref. 5). SQ SEQUENCE 532 AA; 60074 MW; EE846186F645DD9B CRC64; MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLISFI LWAPAILCWQ YLVGKRTVPL DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE KRKPAHRALF RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE TEKSDYDTPN YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV KIMPCPFPVA KEPSTKGLNP NPSHQMTKRK RVVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTV NPICYALCNR TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP // ID ACM4_MOUSE STANDARD; PRT; 479 AA. AC P32211; Q64056; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 18-APR-2006, entry version 47. DE Muscarinic acetylcholine receptor M4 (Mm4 mAChR). GN Name=Chrm4; Synonyms=Chrm-4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=93305731; PubMed=7916637; DOI=10.1016/0167-4781(93)90135-Z; RA van Koppen C.J., Lenz W., Nathanson N.M.; RT "Isolation, sequence and functional expression of the mouse m4 RT muscarinic acetylcholine receptor gene."; RL Biochim. Biophys. Acta 1173:342-344(1993). RN [2] RP NUCLEOTIDE SEQUENCE OF 235-355. RC TISSUE=Brain; RX MEDLINE=95179320; PubMed=7874308; RA Andre C., Dos Santos G., Koulakoff A.; RT "Cultured neurons from mouse brain reproduce the muscarinic receptor RT profile of their tissue of origin."; RL Eur. J. Neurosci. 6:1691-1701(1994). CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is inhibition of adenylate cyclase. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X63473; CAA45071.1; -; Genomic_DNA. DR EMBL; S74916; AAB33577.1; -; mRNA. DR PIR; S33776; S33776. DR UniGene; Mm.330405; -. DR HSSP; P02699; 1BOJ. DR Ensembl; ENSMUSG00000040495; Mus musculus. DR MGI; MGI:88399; Chrm4. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001432; Musac_M4_rcpt. DR InterPro; IPR000995; Musac_rcpt. DR PANTHER; PTHR19266:SF85; M4_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PRINTS; PR00541; MUSCRINICM4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphorylation; KW Postsynaptic membrane; Receptor; Transducer; Transmembrane. FT CHAIN 1 479 Muscarinic acetylcholine receptor M4. FT /FTId=PRO_0000069038. FT TOPO_DOM 1 30 Extracellular (Potential). FT TRANSMEM 31 53 1 (Potential). FT TOPO_DOM 54 67 Cytoplasmic (Potential). FT TRANSMEM 68 88 2 (Potential). FT TOPO_DOM 89 105 Extracellular (Potential). FT TRANSMEM 106 127 3 (Potential). FT TOPO_DOM 128 147 Cytoplasmic (Potential). FT TRANSMEM 148 170 4 (Potential). FT TOPO_DOM 171 192 Extracellular (Potential). FT TRANSMEM 193 215 5 (Potential). FT TOPO_DOM 216 401 Cytoplasmic (Potential). FT TRANSMEM 402 422 6 (Potential). FT TOPO_DOM 423 436 Extracellular (Potential). FT TRANSMEM 437 456 7 (Potential). FT TOPO_DOM 457 479 Cytoplasmic (Potential). FT MOD_RES 459 459 Phosphothreonine (Potential). FT MOD_RES 463 463 Phosphothreonine (Potential). FT MOD_RES 477 477 Phosphothreonine (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential). FT DISULFID 104 184 By similarity. FT CONFLICT 322 323 AL -> V (in Ref. 2). FT CONFLICT 351 351 S -> N (in Ref. 2). SQ SEQUENCE 479 AA; 52973 MW; 04F301E78814CD70 CRC64; MANFTPVNGS SANQSVRLVT TAHNHLETVE MVFIATVTGS LSLVTVVGNI LVMLSIKVNR QLQTVNNYFL FSLACADLII GAFSMNLYTL YIIKGYWPLG AVVCDLWLAL DYVVSNASVM NLLIISFDRY FCVTKPLTYP ARRTTKMAGL MIAAAWVLSF VLWAPAILFW QFVVGKRTVP DNQCFIQFLS NPAVTFGTAI AAFYLPVVIM TVLYIHISLA SRSRVHKHRP EGPKEKKAKT LAFLKSPLMK PSIKKPPPGG ASREELRNGK LEEAPPPALP PPPRPVADKD TSNESSSGSA TQNTKERPPT ELSTTEAATT PALPAPTLQP RTLNPASKWS KIQIVTKQTG SECVTAIEIV PATPAGMRPA ANVARKFASI ARNQVRKKRQ MAARERKVTR TIFAILLAFI LTWTPYNVMV LVNTFCQSCI PERVWSIGYW LCYVNSTINP ACYALCNATF KKTFRHLLLC QYRNIGTAR // ID ACM2_HUMAN STANDARD; PRT; 466 AA. AC P08172; Q9P1X9; DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1988, sequence version 1. DT 18-APR-2006, entry version 66. DE Muscarinic acetylcholine receptor M2. GN Name=CHRM2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=87263421; PubMed=3037705; RA Bonner T.I., Buckley N.J., Young A.C., Brann M.R.; RT "Identification of a family of muscarinic acetylcholine receptor RT genes."; RL Science 237:527-532(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=88166632; PubMed=3443095; RA Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J., RA Capon D.J.; RT "Distinct primary structures, ligand-binding properties and tissue- RT specific expression of four human muscarinic acetylcholine RT receptors."; RL EMBO J. 6:3923-3929(1987). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-466. RA Kitano T., Kobayakawa H., Saitou N.; RT "Silver project."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is adenylate cyclase inhibition. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M16404; AAA51570.1; -; Genomic_DNA. DR EMBL; X15264; CAA33335.1; -; Genomic_DNA. DR EMBL; AF498916; AAM18939.1; -; mRNA. DR EMBL; AB041391; BAA94476.1; -; Genomic_DNA. DR PIR; S10126; S10126. DR UniGene; Hs.535891; -. DR PDB; 1LUB; Model; A=1-50. DR Ensembl; ENSG00000181072; Homo sapiens. DR H-InvDB; HIX0007117; -. DR HGNC; HGNC:1951; CHRM2. DR MIM; 118493; gene. DR LinkHub; P08172; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0004981; F:muscarinic acetylcholine receptor activity; TAS. DR GO; GO:0007188; P:G-protein signaling, coupled to cAMP nucleo...; TAS. DR GO; GO:0007207; P:muscarinic acetylcholine receptor, phosphol...; TAS. DR GO; GO:0007399; P:nervous system development; TAS. DR GO; GO:0008016; P:regulation of heart contraction; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001065; Musac_M2_rcpt. DR InterPro; IPR000995; Musac_rcpt. DR PANTHER; PTHR19266:SF84; M2_receptor; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PRINTS; PR00539; MUSCRINICM2R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW 3D-structure; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Postsynaptic membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 466 Muscarinic acetylcholine receptor M2. FT /FTId=PRO_0000069021. FT TOPO_DOM 1 22 Extracellular (Potential). FT TRANSMEM 23 45 1 (Potential). FT TOPO_DOM 46 59 Cytoplasmic (Potential). FT TRANSMEM 60 80 2 (Potential). FT TOPO_DOM 81 97 Extracellular (Potential). FT TRANSMEM 98 119 3 (Potential). FT TOPO_DOM 120 139 Cytoplasmic (Potential). FT TRANSMEM 140 162 4 (Potential). FT TOPO_DOM 163 184 Extracellular (Potential). FT TRANSMEM 185 207 5 (Potential). FT TOPO_DOM 208 388 Cytoplasmic (Potential). FT TRANSMEM 389 409 6 (Potential). FT TOPO_DOM 410 423 Extracellular (Potential). FT TRANSMEM 424 443 7 (Potential). FT TOPO_DOM 444 466 Cytoplasmic (Potential). FT MOD_RES 446 446 Phosphothreonine (Potential). FT MOD_RES 450 450 Phosphothreonine (Potential). FT MOD_RES 465 465 Phosphothreonine (Potential). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT DISULFID 96 176 By similarity. FT STRAND 5 7 FT TURN 8 9 FT STRAND 10 14 FT HELIX 16 18 FT TURN 24 26 FT STRAND 27 27 FT TURN 30 32 FT STRAND 33 33 FT HELIX 35 49 SQ SEQUENCE 466 AA; 51715 MW; 2FC2FD7748C22BEC CRC64; MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI VKPNNNNMPS SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR // ID ACM3_CAEEL STANDARD; PRT; 611 AA. AC Q9U7D5; Q7JKV1; Q9XW31; DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot. DT 23-NOV-2004, sequence version 2. DT 04-APR-2006, entry version 38. DE Muscarinic acetylcholine receptor gar-3 (G-protein linked DE acetylcholine receptor 3). GN Name=gar-3; ORFNames=Y40H4A.1; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND FUNCTION. RC STRAIN=Bristol N2; RX MEDLINE=20100976; PubMed=10635059; RA Hwang J.M., Chang D.-J., Kim U.S., Lee Y.-S., Park Y.-S., Kaang B.-K., RA Cho N.J.; RT "Cloning and functional characterization of a Caenorhabditis elegans RT muscarinic acetylcholine receptor."; RL Recept. Channels 6:415-424(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, AND RP DEVELOPMENTAL STAGE. RX MEDLINE=22808153; PubMed=12927813; DOI=10.1016/S0006-291X(03)01508-0; RA Park Y.-S., Kim S., Shin Y., Choi B., Cho N.J.; RT "Alternative splicing of the muscarinic acetylcholine receptor GAR-3 RT in Caenorhabditis elegans."; RL Biochem. Biophys. Res. Commun. 308:961-965(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). RN [4] RP SEQUENCE REVISION, AND ALTERNATIVE SPLICING. RG WormBase consortium; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is Pi turnover. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=b; Synonyms=GAR-3a; CC IsoId=Q9U7D5-1; Sequence=Displayed; CC Name=a; Synonyms=GAR-3b; CC IsoId=Q9U7D5-2; Sequence=VSP_012003; CC -!- DEVELOPMENTAL STAGE: Isoform a and isoform b are expressed at all CC developmental stages examined, isoform a is more abundant at CC embryonic and early larval stages and isoform b at first larval CC instar. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF139093; AAD48771.1; -; mRNA. DR EMBL; AY221631; AAP97492.1; -; mRNA. DR EMBL; AL034391; CAA22301.2; -; Genomic_DNA. DR EMBL; Z81486; CAA22301.2; JOINED; Genomic_DNA. DR EMBL; AL034391; CAE47471.1; -; Genomic_DNA. DR EMBL; Z81486; CAE47471.1; JOINED; Genomic_DNA. DR EMBL; Z81486; CAC42272.1; -; Genomic_DNA. DR EMBL; AL034391; CAC42272.1; JOINED; Genomic_DNA. DR EMBL; Z81486; CAE47465.1; -; Genomic_DNA. DR EMBL; AL034391; CAE47465.1; JOINED; Genomic_DNA. DR PIR; T20171; T20171. DR UniGene; Cel.19494; -. DR Ensembl; Y40H4A.1; Caenorhabditis elegans. DR WormBase; WBGene00001519; gar-3. DR WormPep; Y40H4A.1a; CE27783. DR WormPep; Y40H4A.1b; CE35800. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000995; Musac_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; Complete proteome; G-protein coupled receptor; KW Glycoprotein; Membrane; Receptor; Transducer; Transmembrane. FT CHAIN 1 611 Muscarinic acetylcholine receptor gar-3. FT /FTId=PRO_0000069050. FT TOPO_DOM 1 67 Extracellular (Potential). FT TRANSMEM 68 88 1 (Potential). FT TOPO_DOM 89 101 Cytoplasmic (Potential). FT TRANSMEM 102 122 2 (Potential). FT TOPO_DOM 123 140 Extracellular (Potential). FT TRANSMEM 141 161 3 (Potential). FT TOPO_DOM 162 181 Cytoplasmic (Potential). FT TRANSMEM 182 202 4 (Potential). FT TOPO_DOM 203 227 Extracellular (Potential). FT TRANSMEM 228 248 5 (Potential). FT TOPO_DOM 249 525 Cytoplasmic (Potential). FT TRANSMEM 526 546 6 (Potential). FT TOPO_DOM 547 557 Extracellular (Potential). FT TRANSMEM 558 578 7 (Potential). FT TOPO_DOM 579 611 Cytoplasmic (Potential). FT CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). FT CARBOHYD 33 33 N-linked (GlcNAc...) (Potential). FT DISULFID 138 218 By similarity. FT VARSPLIC 271 296 Missing (in isoform a). FT /FTId=VSP_012003. SQ SEQUENCE 611 AA; 69563 MW; F1DD615020CA3180 CRC64; MQSSSLGNAD DPRFRQTHLF QMLVKVINTS AENATKTAIA TSSTSTPSFV DTYSTSSLLG EEGRMVMIVV IGAMFALVTS LGNLMVMVSF KIDKQLQTIS NYFLFSLAVA DIAIGVISIP MFTYYTAIQK WDLGYTMCQF WLCIDYLMSN ASVLNLLLIS FDRYFSVTRP LSYRPRRTTK KALTMIACTY IISLILWPPW IISWPYIEGK FTAEPGTCVV QFLQTNPYVT VGTAVAAFYL PVTIMCILYT RVYWETQKRQ KEFGKLQATQ TWASDVVDRP STQSFRNSKM WKKVKKFSRR SMKRDVSSTS IIKSSGSMRK KNNQDGYVED SVTPCTSSRN SKRKSWLRNC TGKSNSSSED SSEAVAMNLD DTSLSSSHFA LSGSRRRNIS PPCTPMPTNF EDEEQTDAGA SMRNGSARFR SRPSDTGKNN NSDTYTVLIE LNDEGSRPSV RLSSCEPYLD EPISTRNRSK SDCNSEIDER RHSLLNKQSP FKNGRILKNF SSQERKSEKE QRKNERKQES KAAKTLSAIL CAFIATWTPY NLIVCWEAFF PNTVPNVLWT FSYFLCYINS TINPLCYALC NARFRHTYMR ILRCKFKAER PTMNQGYVRR N // ID HRH4_HUMAN STANDARD; PRT; 390 AA. AC Q9H3N8; Q9GZQ0; DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 2. DT 18-APR-2006, entry version 45. DE Histamine H4 receptor (HH4R) (GPRv53) (G-protein coupled receptor 105) DE (GPCR105) (SP9144) (AXOR35). GN Name=HRH4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=20538417; PubMed=10973974; DOI=10.1074/jbc.M006480200; RA Oda T., Morikawa N., Saito Y., Masuho Y., Matsumoto S.; RT "Molecular cloning and characterization of a novel type of histamine RT receptor preferentially expressed in leukocytes."; RL J. Biol. Chem. 275:36781-36786(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RC TISSUE=Leukocyte; RX MEDLINE=20568725; PubMed=11118334; DOI=10.1006/bbrc.2000.4008; RA Nakamura T., Itadani H., Hidaka Y., Ohta M., Tanaka K.; RT "Molecular cloning and characterization of a new human histamine RT receptor, HH4R."; RL Biochem. Biophys. Res. Commun. 279:615-620(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Jones P.G., Wu S., Betty M.; RT "Cloning of a novel histamine receptor."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RC TISSUE=Bone marrow; RX PubMed=11179434; RA Liu C., Ma X.-J., Jiang X., Wilson S.J., Hofstra C.L., Blevitt J., RA Pyati J., Li X., Chai W., Carruthers N., Lovenberg T.W.; RT "Cloning and pharmacological characterization of a fourth histamine RT receptor (H4) expressed in bone marrow."; RL Mol. Pharmacol. 59:420-426(2001). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RC TISSUE=Eosinophil; RX MEDLINE=21104636; PubMed=11181941; RA Morse K.L., Behan J., Laz T.M., West R.E. Jr., Greenfeder S.A., RA Anthes J.C., Umland S., Wan Y., Hipkin R.W., Gonsiorek W., Shin N., RA Gustafson E.L., Qiao X., Wang S., Hedrick J.A., Greene J., Bayne M., RA Monsma F.J. Jr.; RT "Cloning and characterization of a novel human histamine receptor."; RL J. Pharmacol. Exp. Ther. 296:1058-1066(2001). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=21106320; PubMed=11179436; RA Zhu Y., Michalovich D., Wu H.-L., Tan K.B., Dytko G.M., Mannan I.J., RA Boyce R., Alston J., Tierney L.A., Li X., Herrity N.C., Vawter L., RA Sarau H.M., Ames R.S., Davenport C.M., Hieble P., Wilson S., RA Bergsma D.J., Fitzgerald L.R.; RT "Cloning, expression, and pharmacological characterization of a novel RT human histamine receptor."; RL Mol. Pharmacol. 59:434-441(2001). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA]. RA O'Reilly M.A.; RT "Identification of a histamine H4 receptor on human eosinophils - Role RT in eosinophil chemotaxis."; RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The H4 subclass of histamine receptors could mediate the CC histamine signals in peripheral tissues. Displays a significant CC level of constitutive activity (spontaneous activity in the CC absence of agonist). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed primarily in the bone marrow and CC eosinophils. Shows preferential distribution in cells of CC immunological relevance such as T-cells, dendritic cells, CC monocytes, mast cells, neutrophils. Also expressed in a wide CC variety of peripheral tissues, including the heart, kidney, liver, CC lung, pancreas, skeletal muscle, prostate, small intestine, CC spleen, fetal liver and lymph node. CC -!- INDUCTION: Expression is either up-regulated or down-regulated CC upon activation of the lymphoid tissues and this regulation may CC depend on the presence of IL-10 or IL-13. CC -!- MISCELLANEOUS: Does not bind diphenhydramine, loratadine, CC ranitidine, cimetidine and chlorpheniramine. Shows modest affinity CC for dimaprit, impromidine, clobenpropit, thioperamide, burimamide CC clozapine, immepip and imetit. The order of inhibitory activity CC was imetit > clobenpropit > burimamide > thioperamide. CC Clobenpropit behaves as a partial agonist, dimaprit and CC impromidine show some agonist activity while clozapine behaves as CC a full agonist. Thioperamide shows inverse agonism (enhances cAMP CC activity). The order of inhibitory activity of histamine CC derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha- CC methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha- CC methylhistamine > R(-)-alpha-methylhistamine behave as full CC agonists. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB044934; BAB13698.1; -; mRNA. DR EMBL; AB045370; BAB20091.1; -; mRNA. DR EMBL; AF307973; AAG32052.1; -; mRNA. DR EMBL; AF312230; AAK12081.1; -; mRNA. DR EMBL; AF329449; AAK43542.1; -; mRNA. DR EMBL; AF325356; AAL01684.1; -; mRNA. DR EMBL; AJ298292; CAC83493.1; -; mRNA. DR EMBL; AY136745; AAN01271.1; -; mRNA. DR PIR; JC7566; JC7566. DR UniGene; Hs.287388; -. DR Ensembl; ENSG00000134489; Homo sapiens. DR HGNC; HGNC:17383; HRH4. DR MIM; 606792; gene. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0004969; F:histamine receptor activity; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR008102; Histamn_H4_rcpt. DR PANTHER; PTHR19266:SF82; Histamnrecept_H4; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01726; HISTAMINEH4R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Receptor; Transducer; Transmembrane. FT CHAIN 1 390 Histamine H4 receptor. FT /FTId=PRO_0000069693. FT TOPO_DOM 1 19 Extracellular (Potential). FT TRANSMEM 20 40 1 (Potential). FT TOPO_DOM 41 52 Cytoplasmic (Potential). FT TRANSMEM 53 73 2 (Potential). FT TOPO_DOM 74 87 Extracellular (Potential). FT TRANSMEM 88 108 3 (Potential). FT TOPO_DOM 109 131 Cytoplasmic (Potential). FT TRANSMEM 132 152 4 (Potential). FT TOPO_DOM 153 172 Extracellular (Potential). FT TRANSMEM 173 193 5 (Potential). FT TOPO_DOM 194 304 Cytoplasmic (Potential). FT TRANSMEM 305 325 6 (Potential). FT TOPO_DOM 326 341 Extracellular (Potential). FT TRANSMEM 342 362 7 (Potential). FT TOPO_DOM 363 390 Cytoplasmic (Potential). FT LIPID 374 374 S-palmitoyl cysteine (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT DISULFID 87 164 By similarity. FT CONFLICT 138 138 A -> V (in Ref. 1). FT CONFLICT 206 206 H -> R (in Ref. 1). FT CONFLICT 253 253 Q -> R (in Ref. 1). SQ SEQUENCE 390 AA; 44496 MW; C986B8AE7FF912C3 CRC64; MPDTNSTINL SLSTRVTLAF FMSLVAFAIM LGNALVILAF VVDKNLRHRS SYFFLNLAIS DFFVGVISIP LYIPHTLFEW DFGKEICVFW LTTDYLLCTA SVYNIVLISY DRYLSVSNAV SYRTQHTGVL KIVTLMVAVW VLAFLVNGPM ILVSESWKDE GSECEPGFFS EWYILAITSF LEFVIPVILV AYFNMNIYWS LWKRDHLSRC QSHPGLTAVS SNICGHSFRG RLSSRRSLSA STEVPASFHS ERQRRKSSLM FSSRTKMNSN TIASKMGSFS QSDSVALHQR EHVELLRARR LAKSLAILLG VFAVCWAPYS LFTIVLSFYS SATGPKSVWY RIAFWLQWFN SFVNPLLYPL CHKRFQKAFL KIFCIKKQPL PSQHSRSVSS // ID 5HT6R_HUMAN STANDARD; PRT; 440 AA. AC P50406; Q13640; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 18-APR-2006, entry version 46. DE 5-hydroxytryptamine 6 receptor (5-HT-6) (Serotonin receptor 6). GN Name=HTR6; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Corpus striatum; RX MEDLINE=96102917; PubMed=8522988; RA Kohen R., Metcalf M.A., Khan N., Druck T., Huebner K., Lachowicz J.E., RA Sibley D.R., Roth B., Hamblin M.W.; RT "Cloning, characterization, and chromosomal localization of a human 5- RT HT6 serotonin receptor."; RL J. Neurochem. 66:47-56(1996). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Fetal brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 215-280. RC TISSUE=Corpus striatum; RX MEDLINE=95385798; PubMed=7656980; DOI=10.1016/0014-5793(95)00828-W; RA Ullmer C., Schmuck K., Kalkman H.O., Luebbert H.; RT "Expression of serotonin receptor mRNAs in blood vessels."; RL FEBS Lett. 370:215-221(1995). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that stimulate adenylate CC cyclase. It has a high affinity for tricyclic psychotropic drugs. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in several human brain regions, most CC prominently in the caudate nucleus. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L41147; AAA92622.1; -; mRNA. DR EMBL; AY429105; AAR07900.1; -; mRNA. DR EMBL; BC074995; AAH74995.1; -; mRNA. DR EMBL; BC074996; AAH74996.1; -; mRNA. DR EMBL; Z49119; CAA88929.1; -; mRNA. DR PIR; JC5520; JC5520. DR UniGene; Hs.22180; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSG00000158748; Homo sapiens. DR HGNC; HGNC:5301; HTR6. DR MIM; 601109; gene. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004969; F:histamine receptor activity; TAS. DR GO; GO:0007187; P:G-protein signaling, coupled to cyclic nucl...; TAS. DR GO; GO:0007268; P:synaptic transmission; TAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Membrane; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 440 5-hydroxytryptamine 6 receptor. FT /FTId=PRO_0000068974. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 57 1 (Potential). FT TOPO_DOM 58 64 Cytoplasmic (Potential). FT TRANSMEM 65 85 2 (Potential). FT TOPO_DOM 86 100 Extracellular (Potential). FT TRANSMEM 101 122 3 (Potential). FT TOPO_DOM 123 144 Cytoplasmic (Potential). FT TRANSMEM 145 166 4 (Potential). FT TOPO_DOM 167 184 Extracellular (Potential). FT TRANSMEM 185 208 5 (Potential). FT TOPO_DOM 209 265 Cytoplasmic (Potential). FT TRANSMEM 266 290 6 (Potential). FT TOPO_DOM 291 295 Extracellular (Potential). FT TRANSMEM 296 320 7 (Potential). FT TOPO_DOM 321 440 Cytoplasmic (Potential). FT DISULFID 99 180 By similarity. FT CONFLICT 247 247 V -> M (in Ref. 4). SQ SEQUENCE 440 AA; 46954 MW; C888F47650C1D2EF CRC64; MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN // ID ACM1_CAEEL STANDARD; PRT; 713 AA. AC Q18007; Q9NJS7; Q9NJS8; Q9XTK1; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 06-JUN-2002, sequence version 3. DT 04-APR-2006, entry version 48. DE Probable muscarinic acetylcholine receptor gar-1 (G-protein linked DE acetylcholine receptor 1). GN Name=gar-1; ORFNames=C15B12.5; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). RC STRAIN=Bristol N2; RX MEDLINE=99101145; PubMed=9886054; RA Lee Y.-S., Park Y.-S., Chang D.-J., Hwang J.M., Min C.K., Kaang B.-K., RA Cho N.J.; RT "Cloning and expression of a G protein-linked acetylcholine receptor RT from Caenorhabditis elegans."; RL J. Neurochem. 72:58-65(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING. RC STRAIN=Bristol N2; RX MEDLINE=20145436; PubMed=10679207; DOI=10.1006/bbrc.2000.2108; RA Park Y.-S., Lee Y.-S., Cho N.J., Kaang B.-K.; RT "Alternative splicing of gar-1, a Caenorhabditis elegans G-protein- RT linked acetylcholine receptor gene."; RL Biochem. Biophys. Res. Commun. 268:354-358(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). RN [4] RP SEQUENCE REVISION, AND ALTERNATIVE SPLICING. RG WormBase consortium; RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. RN [5] RP TISSUE SPECIFICITY. RX MEDLINE=20490918; PubMed=11032868; RA Lee Y.-S., Park Y.-S., Nam S., Suh S.J., Lee J., Kaang B.-K., RA Cho N.J.; RT "Characterization of GAR-2, a novel G protein-linked acetylcholine RT receptor from Caenorhabditis elegans."; RL J. Neurochem. 75:1800-1809(2000). CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is Pi turnover. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=B; Synonyms=A, Large; CC IsoId=Q18007-1; Sequence=Displayed; CC Name=A; Synonyms=B, Medium; CC IsoId=Q18007-2; Sequence=VSP_001860; CC Name=C; Synonyms=Small; CC IsoId=Q18007-3; Sequence=VSP_001860, VSP_001861; CC -!- TISSUE SPECIFICITY: Expressed in head region of the larva. In CC adults, expression is seen in the periventricularis CC magnocellularis (PVM) neuron. CC -!- DEVELOPMENTAL STAGE: Expressed throughout development from CC embryonic to adult stage, highest level seen in early larvae. CC Isoform A is the most abundant and isoform C is the least. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF075245; AAD13747.1; -; mRNA. DR EMBL; AF117300; AAF26201.1; -; mRNA. DR EMBL; AF117301; AAF26202.1; -; mRNA. DR EMBL; U23529; AAL32209.1; -; Genomic_DNA. DR EMBL; U23529; AAL32210.1; -; Genomic_DNA. DR EMBL; U23529; AAL32211.1; -; Genomic_DNA. DR PIR; T43292; T43292. DR UniGene; Cel.19523; -. DR Ensembl; C15B12.5; Caenorhabditis elegans. DR WormBase; WBGene00001517; gar-1. DR WormPep; C15B12.5a; CE29666. DR WormPep; C15B12.5b; CE29667. DR WormPep; C15B12.5c; CE29668. DR GO; GO:0045211; C:postsynaptic membrane; IDA. DR GO; GO:0016907; F:G-protein coupled acetylcholine receptor ac...; IDA. DR GO; GO:0007271; P:synaptic transmission, cholinergic; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR000995; Musac_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; Complete proteome; G-protein coupled receptor; KW Glycoprotein; Membrane; Receptor; Transducer; Transmembrane. FT CHAIN 1 713 Probable muscarinic acetylcholine FT receptor gar-1. FT /FTId=PRO_0000069048. FT TOPO_DOM 1 20 Extracellular (Potential). FT TRANSMEM 21 41 1 (Potential). FT TOPO_DOM 42 66 Cytoplasmic (Potential). FT TRANSMEM 67 87 2 (Potential). FT TOPO_DOM 88 101 Extracellular (Potential). FT TRANSMEM 102 122 3 (Potential). FT TOPO_DOM 123 144 Cytoplasmic (Potential). FT TRANSMEM 145 165 4 (Potential). FT TOPO_DOM 166 189 Extracellular (Potential). FT TRANSMEM 190 210 5 (Potential). FT TOPO_DOM 211 633 Cytoplasmic (Potential). FT TRANSMEM 634 656 6 (Potential). FT TOPO_DOM 657 670 Extracellular (Potential). FT TRANSMEM 671 693 7 (Potential). FT TOPO_DOM 694 713 Cytoplasmic (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 99 180 By similarity. FT VARSPLIC 275 305 Missing (in isoform A and isoform C). FT /FTId=VSP_001860. FT VARSPLIC 533 593 DDSSSEVEGEEKPEVRNNGLKIPQLTVNNENRGETSSQPGR FT DRLAPPNKTDTFLSASGVSR -> E (in isoform C). FT /FTId=VSP_001861. SQ SEQUENCE 713 AA; 80404 MW; 114EA5065876DEBF CRC64; MPNYTVPPDP ADTSWDSPYS IPVQIVVWII IIVLSLETII GNAMVVMAYR IERNISKQVS NRYIVSLAIS DLIIGIEGFP FFTVYVLNGD RWPLGWVACQ TWLFLDYTLC LVSILTVLLI TADRYLSVCH TAKYLKWQSP TKTQLLIVMS WLLPAIIFGI MIYGWQAMTG QSTSMSGAEC SAPFLSNPYV NMGMYVAYYW TTLVAMLILY KGIHQAAKNL EKKAKAKERR HIALILSQRL GTQVGVSLML QSKAEKEKAE EAQKDSGYTS NQAGDANNLR RFGFSEPETS QFRVDPNSNN NLNVEGSLNT ENDQNLGVIE EERSGFLSRR ESNESYYPGP HPTAANSRRC SEMEKVSLLS ESDGVPSTRP AKSYGRLSLR SRYSASESIT TTHENDEKEV EKADSLQKLF ADDELGSVLN FKEEKLKNTD SNNDSDTTSV ILQRSRKYKK NKRPRSSRRS EHSTPRQIAK VKQAEGTAAQ LIEESVPDDD QTETIEVKRT DRWVVSMKKR IARALIRRRS TTRPERGSSS NSDDSSSEVE GEEKPEVRNN GLKIPQLTVN NENRGETSSQ PGRDRLAPPN KTDTFLSASG VSRKISTIST VITREKVISS IFAPIAVFNR GRKQTKAEKR AHKAFRTITF IVGFFAILWS PYYIMATVYG FCKGECIPSF LYTLSYYMCY LNSSGNPFAY ALANRQFRSA FMRMFRGNFN KVA // ID OP1S1_BRARE STANDARD; PRT; 336 AA. AC Q9W6A9; Q8AYM5; DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-2005, sequence version 2. DT 04-APR-2006, entry version 36. DE Opsin-1, short-wave-sensitive 1 (Ultraviolet-sensitive opsin) DE (Ultraviolet cone photoreceptor pigment) (Opsin SWS-1). GN Name=opn1sw1; Synonyms=opn1sw2, sws1, uvops; OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Eye; RX MEDLINE=99277479; PubMed=10349976; RA Vihtelic T.S., Doro C.J., Hyde D.R.; RT "Cloning and characterization of six zebrafish photoreceptor opsin RT cDNAs and immunolocalization of their corresponding proteins."; RL Vis. Neurosci. 16:571-585(1999). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND BIOPHYSICOCHEMICAL RP PROPERTIES. RC STRAIN=AB; TISSUE=Eye; RX MEDLINE=22505400; PubMed=12618404; RA Chinen A., Hamaoka T., Yamada Y., Kawamura S.; RT "Gene duplication and spectral diversification of cone visual pigments RT of zebrafish."; RL Genetics 163:663-675(2003). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Absorption: CC Abs(max)=355 nm; CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Retinal short single cones, outer and inner CC segments. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF109373; AAD24756.1; -; mRNA. DR EMBL; AB087810; BAC24134.1; -; Genomic_DNA. DR UniGene; Dr.8194; -. DR HSSP; P02699; 1FDF. DR Ensembl; ENSDARG00000001917; Danio rerio. DR ZFIN; ZDB-GENE-991109-25; opn1sw1. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0009881; F:photoreceptor activity; NAS. DR GO; GO:0007601; P:visual perception; NAS. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR001521; Opsin_blue. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00574; OPSINBLUE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 336 Opsin-1, short-wave-sensitive 1. FT /FTId=PRO_0000197805. FT TOPO_DOM 1 29 Extracellular (By similarity). FT TRANSMEM 30 54 1 (Potential). FT TOPO_DOM 55 66 Cytoplasmic (By similarity). FT TRANSMEM 67 91 2 (Potential). FT TOPO_DOM 92 106 Extracellular (By similarity). FT TRANSMEM 107 126 3 (Potential). FT TOPO_DOM 127 145 Cytoplasmic (By similarity). FT TRANSMEM 146 169 4 (Potential). FT TOPO_DOM 170 195 Extracellular (By similarity). FT TRANSMEM 196 223 5 (Potential). FT TOPO_DOM 224 245 Cytoplasmic (By similarity). FT TRANSMEM 246 269 6 (Potential). FT TOPO_DOM 270 277 Extracellular (By similarity). FT TRANSMEM 278 302 7 (Potential). FT TOPO_DOM 303 336 Cytoplasmic (By similarity). FT BINDING 289 289 Retinal chromophore (covalent) (By FT similarity). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT DISULFID 103 180 By similarity. FT CONFLICT 88 88 F -> S (in Ref. 1). FT CONFLICT 97 97 F -> S (in Ref. 1). FT CONFLICT 104 104 A -> S (in Ref. 1). FT CONFLICT 292 292 C -> S (in Ref. 1). SQ SEQUENCE 336 AA; 37268 MW; 0D6F7D4ADD616293 CRC64; MDAWAVQFGN ASKVSPFEGE QYHIAPKWAF YLQAAFMGFV FIVGTPMNGI VLFVTMKYKK LRQPLNYILV NISLAGFIFD TFSVSQVFVC AARGYYFLGY TLCAMEAAMG SIAGLVTGWS LAVLAFERYV VICKPFGSFK FGQGQAVGAV VFTWIIGTAC ATPPFFGWSR YIPEGLGTAC GPDWYTKSEE YNSESYTYFL LITCFMMPMT IIIFSYSQLL GALRAVAAQQ AESESTQKAE REVSRMVVVM VGSFVLCYAP YAVTAMYFAN SDEPNKDYRL VAIPAFFSKS SCVYNPLIYA FMNKQFNACI METVFGKKID ESSEVSSKTE TSSVSA // ID OPSB_MOUSE STANDARD; PRT; 346 AA. AC P51491; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 18-APR-2006, entry version 48. DE Blue-sensitive opsin (BOP) (Blue cone photoreceptor pigment). GN Name=Opn1sw; Synonyms=Bcp; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Retina; RX MEDLINE=94375074; PubMed=8088841; RA Chiu M.I., Zack D.J., Wang Y., Nathans J.; RT "Murine and bovine blue cone pigment genes: cloning and RT characterization of two new members of the S family of visual RT pigments."; RL Genomics 21:440-443(1994). RN [2] RP NUCLEOTIDE SEQUENCE. RA Chiu M.I., Zack D.J., Wang Y., Nathans J.; RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone CC photoreceptor cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U49720; AAA92458.1; -; mRNA. DR EMBL; U92562; AAB53320.1; -; Genomic_DNA. DR EMBL; U92558; AAB53320.1; JOINED; Genomic_DNA. DR EMBL; U92559; AAB53320.1; JOINED; Genomic_DNA. DR EMBL; U92560; AAB53320.1; JOINED; Genomic_DNA. DR EMBL; U92561; AAB53320.1; JOINED; Genomic_DNA. DR EMBL; BC026021; AAH26021.1; -; mRNA. DR EMBL; BC058267; AAH58267.1; -; mRNA. DR PIR; B54679; B54679. DR UniGene; Mm.56987; -. DR HSSP; P02699; 1FDF. DR Ensembl; ENSMUSG00000058831; Mus musculus. DR MGI; MGI:99438; Opn1sw. DR GO; GO:0001750; C:photoreceptor outer segment; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR001521; Opsin_blue. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00574; OPSINBLUE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 346 Blue-sensitive opsin. FT /FTId=PRO_0000197766. FT TOPO_DOM 1 31 Extracellular. FT TRANSMEM 32 56 1 (Potential). FT TOPO_DOM 57 68 Cytoplasmic. FT TRANSMEM 69 94 2 (Potential). FT TOPO_DOM 95 108 Extracellular. FT TRANSMEM 109 128 3 (Potential). FT TOPO_DOM 129 147 Cytoplasmic. FT TRANSMEM 148 171 4 (Potential). FT TOPO_DOM 172 197 Extracellular. FT TRANSMEM 198 225 5 (Potential). FT TOPO_DOM 226 247 Cytoplasmic. FT TRANSMEM 248 271 6 (Potential). FT TOPO_DOM 272 279 Extracellular. FT TRANSMEM 280 304 7 (Potential). FT TOPO_DOM 305 346 Cytoplasmic. FT BINDING 291 291 Retinal chromophore (covalent). FT CARBOHYD 12 12 N-linked (GlcNAc...) (Probable). FT DISULFID 105 182 Potential. SQ SEQUENCE 346 AA; 38922 MW; 8BEEAB0198EE6863 CRC64; MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN AIVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF GRHVCALEAF LGSVAGLVTG WSLAFLAFER YVVICKPFGS IRFNSKHALM VVLATWIIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEYYTW FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK AEREVSHMVV VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH // ID OPSB_ORYLA STANDARD; PRT; 352 AA. AC P87365; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 07-FEB-2006, entry version 35. DE Blue-sensitive opsin (Blue cone photoreceptor pigment) (KFH-B). OS Oryzias latipes (Medaka fish) (Japanese ricefish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Atherinomorpha; OC Beloniformes; Adrianichthyidae; Oryziinae; Oryzias. OX NCBI_TaxID=8090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Retina; RA Hisatomi O., Satoh T., Tokunaga F.; RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: The color pigments are found in the cone CC photoreceptor cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB001602; BAA19419.1; -; mRNA. DR HSSP; P02699; 1EDV. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR001521; Opsin_blue. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00574; OPSINBLUE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 352 Blue-sensitive opsin. FT /FTId=PRO_0000197758. FT TOPO_DOM 1 42 Extracellular (Potential). FT TRANSMEM 43 67 1 (Potential). FT TOPO_DOM 68 79 Cytoplasmic (Potential). FT TRANSMEM 80 105 2 (Potential). FT TOPO_DOM 106 119 Extracellular (Potential). FT TRANSMEM 120 139 3 (Potential). FT TOPO_DOM 140 158 Cytoplasmic (Potential). FT TRANSMEM 159 182 4 (Potential). FT TOPO_DOM 183 208 Extracellular (Potential). FT TRANSMEM 209 236 5 (Potential). FT TOPO_DOM 237 258 Cytoplasmic (Potential). FT TRANSMEM 259 282 6 (Potential). FT TOPO_DOM 283 290 Extracellular (Potential). FT TRANSMEM 291 315 7 (Potential). FT TOPO_DOM 316 352 Cytoplasmic (Potential). FT BINDING 302 302 Retinal chromophore (covalent) (By FT similarity). FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). FT CARBOHYD 206 206 N-linked (GlcNAc...) (Potential). FT DISULFID 116 193 Potential. SQ SEQUENCE 352 AA; 38906 MW; 68BC44A44F54057D CRC64; MRGNRLVEFP DDFWIPIPLD TNNVTALSPF LVPQDHLGSP TIFYSMSALM FVLFVAGTAI NLLTIACTLQ YKKLRSHLNY ILVNMAVANL IVASTGSSTC FVCFAFKYMV LGPLGCKIEG FTAALGGMVS LWSLAVIAFE RWLVICKPLG NFVFKSEHAL LCCALTWVCG LCASVPPLVG WSRYIPEGMQ CSCGPDWYTT GNKFNNESFV MFLFCFCFAV PFSIIVFCYS QLLFTLKMAA KAQADSASTQ KAEKEVTRMV VVMVVAFLVC YVPYASFALW VINNRGQTFD LRLATIPSCV SKASTVYNPV IYVLLNKQFR LCMKKMLGMS ADEDEESSTS QSTTEVSKVG PS // ID OPSB_ANOCA STANDARD; PRT; 355 AA. AC P51471; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 07-FEB-2006, entry version 37. DE Blue-sensitive opsin (Blue photoreceptor pigment) (RH2 opsin). OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Iguania; Iguanidae; Polychrotinae; Anolis. OX NCBI_TaxID=28377; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=95371134; PubMed=7643409; RA Kawamura S., Yokoyama S.; RT "Paralogous origin of the rhodopsinlike opsin genes in lizards."; RL J. Mol. Evol. 40:594-600(1995). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This opsin uses a vitamin A2 chromophore. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Absorption: CC Abs(max)=~503 nm; CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; S79167; AAB35062.1; -; Genomic_DNA. DR EMBL; S79124; AAB35062.1; JOINED; Genomic_DNA. DR EMBL; S79134; AAB35062.1; JOINED; Genomic_DNA. DR EMBL; S79165; AAB35062.1; JOINED; Genomic_DNA. DR EMBL; S79166; AAB35062.1; JOINED; Genomic_DNA. DR PIR; I51319; I51319. DR HSSP; P02699; 1EDX. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR000732; Rhodopsin. DR PANTHER; PTHR19264:SF16; Rhodopsin; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Lipoprotein; KW Membrane; Palmitate; Phosphorylation; Photoreceptor protein; Receptor; KW Retinal protein; Sensory transduction; Transducer; Transmembrane; KW Vision. FT CHAIN 1 355 Blue-sensitive opsin. FT /FTId=PRO_0000197753. FT TOPO_DOM 1 36 Extracellular. FT TRANSMEM 37 61 1 (Potential). FT TOPO_DOM 62 73 Cytoplasmic. FT TRANSMEM 74 98 2 (Potential). FT TOPO_DOM 99 113 Extracellular. FT TRANSMEM 114 133 3 (Potential). FT TOPO_DOM 134 152 Cytoplasmic. FT TRANSMEM 153 176 4 (Potential). FT TOPO_DOM 177 202 Extracellular. FT TRANSMEM 203 230 5 (Potential). FT TOPO_DOM 231 252 Cytoplasmic. FT TRANSMEM 253 276 6 (Potential). FT TOPO_DOM 277 284 Extracellular. FT TRANSMEM 285 309 7 (Potential). FT TOPO_DOM 310 355 Cytoplasmic. FT BINDING 296 296 Retinal chromophore (covalent) (By FT similarity). FT LIPID 322 322 S-palmitoyl cysteine (By similarity). FT LIPID 323 323 S-palmitoyl cysteine (By similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 By similarity. SQ SEQUENCE 355 AA; 39983 MW; 555B671A4DE96EA6 CRC64; MNGTEGINFY VPLSNKTGLV RSPFEYPQYY LAEPWKYKVV CCYIFFLIFT GLPINILTLL VTFKHKKLRQ PLNYILVNLA VADLFMACFG FTVTFYTAWN GYFIFGPIGC AIEGFFATLG GQVALWSLVV LAIERYIVVC KPMGNFRFSA THALMGISFT WFMSFSCAAP PLLGWSRYIP EGMQCSCGPD YYTLNPDYHN ESYVLYMFGV HFVIPVVVIF FSYGRLICKV REAAAQQQES ASTQKAEREV TRMVILMVLG FLLAWTPYAM VAFWIFTNKG VDFSATLMSV PAFFSKSSSL YNPIIYVLMN KQFRNCMITT ICCGKNPFGD EDVSSSVSQS KTEVSSVSSS QVSPA // ID OPSB_CONCO STANDARD; PRT; 350 AA. AC O13227; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1997, sequence version 1. DT 07-FEB-2006, entry version 40. DE Blue-sensitive opsin (Blue cone photoreceptor pigment). OS Conger conger (Conger eel). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Congridae; OC Conger. OX NCBI_TaxID=82655; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=96288978; PubMed=8763796; RA Archer S., Hirano J.; RT "Absorbance spectra and molecular structure of the blue-sensitive rod RT visual pigment in the conger eel (Conger conger)."; RL Proc. R. Soc. Lond., B, Biol. Sci. 263:761-767(1996). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Absorption: CC Abs(max)=~487 nm; CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates CC vision in dim light. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; S82619; AAB37721.1; -; mRNA. DR HSSP; P02699; 1F88. DR SMR; O13227; 1-345. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR000732; Rhodopsin. DR PANTHER; PTHR19264:SF16; Rhodopsin; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00579; RHODOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 350 Blue-sensitive opsin. FT /FTId=PRO_0000197757. FT TOPO_DOM 1 36 Extracellular (Potential). FT TRANSMEM 37 61 1 (Potential). FT TOPO_DOM 62 73 Cytoplasmic (Potential). FT TRANSMEM 74 98 2 (Potential). FT TOPO_DOM 99 113 Extracellular (Potential). FT TRANSMEM 114 133 3 (Potential). FT TOPO_DOM 134 152 Cytoplasmic (Potential). FT TRANSMEM 153 176 4 (Potential). FT TOPO_DOM 177 202 Extracellular (Potential). FT TRANSMEM 203 230 5 (Potential). FT TOPO_DOM 231 252 Cytoplasmic (Potential). FT TRANSMEM 253 276 6 (Potential). FT TOPO_DOM 277 284 Extracellular (Potential). FT TRANSMEM 285 309 7 (Potential). FT TOPO_DOM 310 350 Cytoplasmic (Potential). FT BINDING 296 296 Retinal chromophore (covalent) (By FT similarity). FT CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT DISULFID 110 187 By similarity. SQ SEQUENCE 350 AA; 39478 MW; 3F7445C609900358 CRC64; MNGTEGPNFY VPMSNATGVV RSPFEYPQYY LAEPWAFSIL AAYMFFLIIT GFPINFLTLY VTIEHKKLRT PLNYILLNLA VADLFMVFGG FTTTMYTSMH GYFVFGETGC NLEGYFATLG GEISLWSLVV LAIERWVVVC KPISNFRFGE NHAIMGLTLT WVMANACAMP PLFGWSRYIP EGLQCSCGID YYTLKPEVNN ESFVIYMFLV HFTIPLTIIS FCYGRLVCAV KEAAAQQQES ETTQRAEREV TRMVVIMVIS FLVCWIPYAS VAWYIFTHQG STFGPIFMTV PSFFAKSSSI YNPMIYICMN KQFRNCMITT LFCGKNPFEG EEEGSTTKTE ASAVSSVSPA // ID OPSP_CHICK STANDARD; PRT; 351 AA. AC P51475; P79794; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 04-APR-2006, entry version 42. DE Pinopsin (Pineal opsin) (P-opsin) (Pineal gland-specific opsin). OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; OC Gallus. OX NCBI_TaxID=9031; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Pineal gland; RX MEDLINE=95184012; PubMed=7878470; RA Max M., McKinnon P.J., Seidenman K.J., Barrett R.K., Applebury M.L., RA Takahashi J.S., Margolskee R.F.; RT "Pineal opsin: a nonvisual opsin expressed in chick pineal."; RL Science 267:1502-1506(1995). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Pineal gland; RX MEDLINE=95059405; PubMed=7969427; DOI=10.1038/372094a0; RA Okano T., Yoshizawa T., Fukada Y.; RT "Pinopsin is a chicken pineal photoreceptive molecule."; RL Nature 372:94-97(1994). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=White leghorn; TISSUE=Pineal gland; RX MEDLINE=98434598; PubMed=9756926; DOI=10.1074/jbc.273.41.26820; RA Max M., Surya A., Takahashi J.S., Margolskee R.F., Knox B.E.; RT "Light-dependent activation of rod transducin by pineal opsin."; RL J. Biol. Chem. 273:26820-26826(1998). CC -!- FUNCTION: Produces a slow and prolonged phototransduction response CC consistent with the nonvisual function of pineal photoreception. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Absorption: CC Abs(max)=~470 nm; CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Pineal gland. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U15762; AAA64223.1; -; mRNA. DR EMBL; U87449; AAB47565.1; -; Genomic_DNA. DR PIR; A55962; A55962. DR UniGene; Gga.786; -. DR HSSP; P02699; 1FDF. DR Ensembl; ENSGALG00000004924; Gallus gallus. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR002206; Opsin_pineal. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00666; PINOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Lipoprotein; KW Membrane; Palmitate; Phosphorylation; Photoreceptor protein; Receptor; KW Retinal protein; Sensory transduction; Transducer; Transmembrane. FT CHAIN 1 351 Pinopsin. FT /FTId=PRO_0000197807. FT TOPO_DOM 1 30 Extracellular. FT TRANSMEM 31 55 1 (Potential). FT TOPO_DOM 56 67 Cytoplasmic. FT TRANSMEM 68 92 2 (Potential). FT TOPO_DOM 93 107 Extracellular. FT TRANSMEM 108 127 3 (Potential). FT TOPO_DOM 128 146 Cytoplasmic. FT TRANSMEM 147 170 4 (Potential). FT TOPO_DOM 171 194 Extracellular. FT TRANSMEM 195 222 5 (Potential). FT TOPO_DOM 223 244 Cytoplasmic. FT TRANSMEM 245 268 6 (Potential). FT TOPO_DOM 269 276 Extracellular. FT TRANSMEM 277 301 7 (Potential). FT TOPO_DOM 302 351 Cytoplasmic. FT BINDING 288 288 Retinal chromophore (covalent). FT LIPID 314 314 S-palmitoyl cysteine (By similarity). FT LIPID 315 315 S-palmitoyl cysteine (By similarity). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 192 192 N-linked (GlcNAc...) (Potential). FT DISULFID 104 181 By similarity. FT CONFLICT 28 28 Q -> W (in Ref. 3). FT CONFLICT 135 135 K -> R (in Ref. 2). FT CONFLICT 163 163 A -> T (in Ref. 2). SQ SEQUENCE 351 AA; 38174 MW; 56BDFAD187008338 CRC64; MSSNSSQAPP NGTPGPFDGP QWPYQAPQST YVGVAVLMGT VVACASVVNG LVIVVSICYK KLRSPLNYIL VNLAVADLLV TLCGSSVSLS NNINGFFVFG RRMCELEGFM VSLTGIVGLW SLAILALERY VVVCKPLGDF QFQRRHAVSG CAFTWGWALL WSAPPLLGWS SYVPEGLRTS CGPNWYTGGS NNNSYILSLF VTCFVLPLSL ILFSYTNLLL TLRAAAAQQK EADTTQRAER EVTRMVIVMV MAFLLCWLPY STFALVVATH KGIIIQPVLA SLPSYFSKTA TVYNPIIYVF MNKQFQSCLL EMLCCGYQPQ RTGKASPGTP GPHADVTAAG LRNKVMPAHP V // ID OPSP_PETMA STANDARD; PRT; 444 AA. AC O42490; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 07-FEB-2006, entry version 36. DE Pineal opsin (P-opsin) (Pineal gland-specific opsin). OS Petromyzon marinus (Sea lamprey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Hyperoartia; OC Petromyzontiformes; Petromyzontidae; Petromyzon. OX NCBI_TaxID=7757; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=98087422; PubMed=9427550; DOI=10.1016/S0378-1119(97)00458-7; RA Yokoyama S., Zhang H.; RT "Cloning and characterization of the pineal gland-specific opsin gene RT of marine lamprey (Petromyzon marinus)."; RL Gene 202:89-93(1997). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Pineal gland. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U90671; AAC41240.1; -; Genomic_DNA. DR EMBL; U90667; AAC41240.1; JOINED; Genomic_DNA. DR EMBL; U90668; AAC41240.1; JOINED; Genomic_DNA. DR EMBL; U90669; AAC41240.1; JOINED; Genomic_DNA. DR EMBL; U90670; AAC41240.1; JOINED; Genomic_DNA. DR HSSP; P02699; 1FDF. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR002206; Opsin_pineal. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00666; PINOPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Lipoprotein; KW Membrane; Palmitate; Phosphorylation; Photoreceptor protein; Receptor; KW Retinal protein; Sensory transduction; Transducer; Transmembrane. FT CHAIN 1 444 Pineal opsin. FT /FTId=PRO_0000197810. FT TOPO_DOM 1 46 Extracellular. FT TRANSMEM 47 71 1 (Potential). FT TOPO_DOM 72 83 Cytoplasmic. FT TRANSMEM 84 108 2 (Potential). FT TOPO_DOM 109 123 Extracellular. FT TRANSMEM 124 143 3 (Potential). FT TOPO_DOM 144 162 Cytoplasmic. FT TRANSMEM 163 186 4 (Potential). FT TOPO_DOM 187 210 Extracellular. FT TRANSMEM 211 238 5 (Potential). FT TOPO_DOM 239 260 Cytoplasmic. FT TRANSMEM 261 284 6 (Potential). FT TOPO_DOM 285 292 Extracellular. FT TRANSMEM 293 317 7 (Potential). FT TOPO_DOM 318 444 Cytoplasmic. FT COMPBIAS 409 418 Poly-Gln. FT BINDING 304 304 Retinal chromophore (covalent). FT LIPID 331 331 S-palmitoyl cysteine (By similarity). FT CARBOHYD 25 25 N-linked (GlcNAc...) (Potential). FT DISULFID 120 197 By similarity. SQ SEQUENCE 444 AA; 48080 MW; 4F62BDA3BA925600 CRC64; MDALQESPPS HHSLPSALPS ATGGNGTVAT MHNPFERPLE GIAPWNFTML AALMGTITAL SLGENFAVIV VTARFRQLRQ PLNYVLVNLA AADLLVSAIG GSVSFFTNIK GYFFLGVHAC VLEGFAVTYF GVVALWSLAL LAFERYFVIC RPLGNFRLQS KHAVLGLAVV WVFSLACTLP PVLGWSSYRP SMIGTTCEPN WYSGELHDHT FILMFFSTCF IFPLAVIFFS YGKLIQKLKK ASETQRGLES TRRAEQQVTR MVVVMILAFL VCWMPYATFS IVVTACPTIH LDPLLAAVPA FFSKTATVYN PVIYIFMNKQ FRDCFVQVLP CKGLKKVSAT QTAGAQDTEH TASVNTQSPG NRHNIALAAG SLRFTGAVAP SPATGVVEPT MSAAGSMGAP PNKSTAPCQQ QGQQQQQQGT PIPAITHVQP LLTHSESVSK ICPV // ID OPS1_DROME STANDARD; PRT; 373 AA. AC P06002; Q4QPQ2; Q9TX56; Q9VDS8; DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot. DT 13-AUG-1987, sequence version 1. DT 04-APR-2006, entry version 69. DE Opsin Rh1 (Outer R1-R6 photoreceptor cells opsin) (Neither DE inactivation nor afterpotential E protein). GN Name=ninaE; Synonyms=Rh1; ORFNames=CG4550; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85176937; PubMed=2985266; DOI=10.1016/0092-8674(85)90343-5; RA O'Tousa J.E., Baehr W., Martin R.L., Hirsh J., Pak W.L., RA Applebury M.L.; RT "The Drosophila ninaE gene encodes an opsin."; RL Cell 40:839-850(1985). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85176938; PubMed=2580638; DOI=10.1016/0092-8674(85)90344-7; RA Zuker C.S., Cowman A.F., Rubin G.M.; RT "Isolation and structure of a rhodopsin gene from D. melanogaster."; RL Cell 40:851-858(1985). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Head; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.E.; RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE OF 26-346. RX MEDLINE=94275868; PubMed=8006992; DOI=10.1007/BF00176087; RA Carulli J.P., Chen D.M., Stark W.S., Hartl D.L.; RT "Phylogeny and physiology of Drosophila opsins."; RL J. Mol. Evol. 38:250-262(1994). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Absorption: CC Abs(max)=480 nm; CC -!- INTERACTION: CC Q04787:bsh; NbExp=1; IntAct=EBI-100064, EBI-96948; CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Each Drosophila eye is composed of 800 facets or CC ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), CC the R1 to R6 cells are outer cells, while R7 and R8 are inner CC cells. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; K02315; AAA28733.1; -; Genomic_DNA. DR EMBL; K02320; AAA28735.1; ALT_SEQ; Genomic_DNA. DR EMBL; K02316; AAA28735.1; JOINED; Genomic_DNA. DR EMBL; K02317; AAA28735.1; JOINED; Genomic_DNA. DR EMBL; K02318; AAA28735.1; JOINED; Genomic_DNA. DR EMBL; K02319; AAA28735.1; JOINED; Genomic_DNA. DR EMBL; AE003728; AAF55712.1; -; Genomic_DNA. DR EMBL; BT010221; AAQ23539.1; -; mRNA. DR EMBL; BT023714; AAY85114.1; -; mRNA. DR PIR; A90864; OOFF. DR UniGene; Dm.6744; -. DR HSSP; P02699; 1EDV. DR IntAct; P06002; -. DR Ensembl; CG4550; Drosophila melanogaster. DR FlyBase; FBgn0002940; ninaE. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-012413-MONOMER; -. DR GO; GO:0016023; C:cytoplasmic membrane-bound vesicle; IDA. DR GO; GO:0016027; C:inaD signaling complex; IPI. DR GO; GO:0005771; C:multivesicular body; IDA. DR GO; GO:0005791; C:rough endoplasmic reticulum; IDA. DR GO; GO:0005767; C:secondary lysosome; IDA. DR GO; GO:0016029; C:subrhabdomeral cisterna; IDA. DR GO; GO:0008020; F:G-protein coupled photoreceptor activity; NAS. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0008594; P:photoreceptor cell morphogenesis (sensu End...; IMP. DR GO; GO:0007602; P:phototransduction; NAS. DR GO; GO:0042052; P:rhabdomere development; IMP. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR001735; Opsin_RH1/RH2. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00576; OPSINRH1RH2. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; Complete proteome; G-protein coupled receptor; KW Glycoprotein; Membrane; Phosphorylation; Photoreceptor protein; KW Receptor; Retinal protein; Sensory transduction; Transducer; KW Transmembrane; Vision. FT CHAIN 1 373 Opsin Rh1. FT /FTId=PRO_0000197622. FT TOPO_DOM 1 49 Extracellular. FT TRANSMEM 50 74 1 (Potential). FT TOPO_DOM 75 86 Cytoplasmic. FT TRANSMEM 87 112 2 (Potential). FT TOPO_DOM 113 126 Extracellular. FT TRANSMEM 127 146 3 (Potential). FT TOPO_DOM 147 165 Cytoplasmic. FT TRANSMEM 166 189 4 (Potential). FT TOPO_DOM 190 213 Extracellular. FT TRANSMEM 214 241 5 (Potential). FT TOPO_DOM 242 276 Cytoplasmic. FT TRANSMEM 277 300 6 (Potential). FT TOPO_DOM 301 307 Extracellular. FT TRANSMEM 308 332 7 (Potential). FT TOPO_DOM 333 373 Cytoplasmic. FT BINDING 319 319 Retinal chromophore (covalent). FT CARBOHYD 20 20 N-linked (GlcNAc...) (Probable). FT DISULFID 123 200 Potential. SQ SEQUENCE 373 AA; 41495 MW; FFF36C90DDD68294 CRC64; MESFAVAAAQ LGPHFAPLSN GSVVDKVTPD MAHLISPYWN QFPAMDPIWA KILTAYMIMI GMISWCGNGV VIYIFATTKS LRTPANLLVI NLAISDFGIM ITNTPMMGIN LYFETWVLGP MMCDIYAGLG SAFGCSSIWS MCMISLDRYQ VIVKGMAGRP MTIPLALGKI AYIWFMSSIW CLAPAFGWSR YVPEGNLTSC GIDYLERDWN PRSYLIFYSI FVYYIPLFLI CYSYWFIIAA VSAHEKAMRE QAKKMNVKSL RSSEDAEKSA EGKLAKVALV TITLWFMAWT PYLVINCMGL FKFEGLTPLN TIWGACFAKS AACYNPIVYG ISHPKYRLAL KEKCPCCVFG KVDDGKSSDA QSQATASEAE SKA // ID OPS1_SCHGR STANDARD; PRT; 381 AA. AC Q94741; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 07-FEB-2006, entry version 39. DE Opsin-1. GN Name=Lo1; OS Schistocerca gregaria (Desert locust). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Orthopteroidea; Orthoptera; Caelifera; Acridomorpha; OC Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca. OX NCBI_TaxID=7010; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=97301174; PubMed=9156194; DOI=10.1016/S0042-6989(96)00198-8; RA Towner P., Harris P., Wolstenholme A.J., Hill C., Worm K., Gartner W.; RT "Primary structure of locust opsins: a speculative model which may RT account for ultraviolet wavelength light detection."; RL Vision Res. 37:495-503(1997). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X80071; CAA56377.1; -; mRNA. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR001391; Opsin_lateye. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00578; OPSINLTRLEYE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 381 Opsin-1. FT /FTId=PRO_0000197635. FT TOPO_DOM 1 53 Extracellular (Potential). FT TRANSMEM 54 78 1 (Potential). FT TOPO_DOM 79 90 Cytoplasmic (Potential). FT TRANSMEM 91 115 2 (Potential). FT TOPO_DOM 116 130 Extracellular (Potential). FT TRANSMEM 131 150 3 (Potential). FT TOPO_DOM 151 169 Cytoplasmic (Potential). FT TRANSMEM 170 193 4 (Potential). FT TOPO_DOM 194 217 Extracellular (Potential). FT TRANSMEM 218 245 5 (Potential). FT TOPO_DOM 246 280 Cytoplasmic (Potential). FT TRANSMEM 281 304 6 (Potential). FT TOPO_DOM 305 311 Extracellular (Potential). FT TRANSMEM 312 336 7 (Potential). FT TOPO_DOM 337 381 Cytoplasmic (Potential). FT BINDING 323 323 Retinal chromophore (covalent) (By FT similarity). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...) (Potential). FT DISULFID 127 204 By similarity. SQ SEQUENCE 381 AA; 42399 MW; 50D38FF9038D5BA3 CRC64; MASASLISEP SFSAYWGGSG GFANQTVVDK VPPEMLYLVD PHWYQFPPMN PLWHGLLGFV IGVLGVISVI GNGMVIYIFS TTKSLRTPSN LLVVNLAFSD FLMMFTMSAP MGINCYYETW VLGPFMCELY ALFGSLFGCG SIWTMTMIAL DRYNVIVKGL SAKPMTNKTA MLRILFIWAF SVAWTIMPLF GWNRYVPEGN MTACGTDYLT KDWVSRSYIL VYSFFVYLLP LGTIIYSYFF ILQAVSAHEK QMREQRKKMN VASLRSAEAS QTSAECKLAK VALMTISLWF FGWTPYLIIN FTGIFETMKI SPLLTIWGSL FAKANAVFNP IVYGISHPKY RAALEKKFPS LACASSSDDN TSVASGATTV SDEKSEKSAS A // ID OPSD_CAMHU STANDARD; PRT; 301 AA. AC O18312; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 07-FEB-2006, entry version 37. DE Rhodopsin (Fragment). GN Name=RHO; OS Cambarus hubrichti (Crayfish). OC Eukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca; OC Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea; OC Astacoidea; Cambaridae; Cambarus. OX NCBI_TaxID=61487; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=97336094; PubMed=9192889; DOI=10.1038/42628; RA Crandall K.A., Hillis D.M.; RT "Rhodopsin evolution in the dark."; RL Nature 387:667-668(1997). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF005385; AAB63376.1; -; Genomic_DNA. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR001391; Opsin_lateye. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00578; OPSINLTRLEYE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN <1 >301 Rhodopsin. FT /FTId=PRO_0000197737. FT TOPO_DOM <1 18 Extracellular. FT TRANSMEM 19 43 1 (Potential). FT TOPO_DOM 44 55 Cytoplasmic. FT TRANSMEM 56 80 2 (Potential). FT TOPO_DOM 81 95 Extracellular. FT TRANSMEM 96 115 3 (Potential). FT TOPO_DOM 116 134 Cytoplasmic. FT TRANSMEM 135 158 4 (Potential). FT TOPO_DOM 159 188 Extracellular. FT TRANSMEM 189 210 5 (Potential). FT TOPO_DOM 211 245 Cytoplasmic. FT TRANSMEM 246 269 6 (Potential). FT TOPO_DOM 270 279 Extracellular. FT TRANSMEM 280 301 7 (Potential). FT BINDING 288 288 Retinal chromophore (covalent) (By FT similarity). FT CARBOHYD 165 165 N-linked (GlcNAc...) (Potential). FT DISULFID 92 169 By similarity. FT NON_TER 1 1 FT NON_TER 301 301 SQ SEQUENCE 301 AA; 34542 MW; 8D456BD50036EC82 CRC64; LHMIHLHWYQ YPPMNPMMYP LLLIFMLFTG ILCLAGNFVT IWVFMNTKSL RTPANLLVVN LAMSDFLMMF TMFPPMMVTC YYHTWTLGPT FCQVYAFLGN LCGCASIWTM VFITFDRYNV IVKGVAGEPL STKKASLWIL SVWVLSTAWC IAPFFGWNHY VPEGNLTGCG TDYLSEDILS RSYLYIYSTW VYFLPLAITI YCYVFIIKAV AAHEKGMRDQ AKKMGIKSLR NEEAQKTSAE CRLAKNAMTT VALWFIAWTP CLLINWVGMF ARSYLSPVYT IWGYVFAKAN AVYNPIVYAI S // ID OPSC1_HEMSA STANDARD; PRT; 377 AA. AC Q25157; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 07-FEB-2006, entry version 38. DE Compound eye opsin BCRH1. OS Hemigrapsus sanguineus (Crab). OC Eukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca; OC Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura; OC Eubrachyura; Grapsoidea; Varunidae; Hemigrapsus. OX NCBI_TaxID=40176; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Eye; RX PubMed=9318091; RA Sakamoto K., Hisatomi O., Tokunaga F., Eguchi E.; RT "Two opsins from the compound eye of the crab Hemigrapsus RT sanguineus."; RL J. Exp. Biol. 199:441-450(1996). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This opsin produces visual pigments with CC maximal absorption in the blue-green region of the spectrum. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in all of the seven retinular cells CC (R1-R7) forming the main rhabdom in each ommatidium. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; D50583; BAA09132.1; -; mRNA. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR001391; Opsin_lateye. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00578; OPSINLTRLEYE. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 377 Compound eye opsin BCRH1. FT /FTId=PRO_0000197749. FT TOPO_DOM 1 53 Extracellular. FT TRANSMEM 54 78 1 (Potential). FT TOPO_DOM 79 90 Cytoplasmic. FT TRANSMEM 91 115 2 (Potential). FT TOPO_DOM 116 131 Extracellular. FT TRANSMEM 132 151 3 (Potential). FT TOPO_DOM 152 170 Cytoplasmic. FT TRANSMEM 171 194 4 (Potential). FT TOPO_DOM 195 218 Extracellular. FT TRANSMEM 219 246 5 (Potential). FT TOPO_DOM 247 281 Cytoplasmic. FT TRANSMEM 282 305 6 (Potential). FT TOPO_DOM 306 313 Extracellular. FT TRANSMEM 314 338 7 (Potential). FT TOPO_DOM 339 377 Cytoplasmic. FT BINDING 325 325 Retinal chromophore (covalent) (By FT similarity). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 128 205 By similarity. SQ SEQUENCE 377 AA; 42196 MW; E994CD2957FE1FCB CRC64; MANVTGPQMA FYGSGAATFG YPEGMTVADF VPDRVKHMVL DHWYNYPPVN PMWHYLLGVV YLFLGVISIA GNGLVIYLYM KSQALKTPAN MLIVNLALSD LIMLTTNFPP FCYNCFSGGR WMFSGTYCEI YAALGAITGV CSIWTLCMIS FDRYNIICNG FNGPKLTQGK ATFMCGLAWV ISVGWSLPPF FGWGSYTLEG ILDSCSYDYF TRDMNTITYN ICIFIFDFFL PASVIVFSYV FIVKAIFAHE AAMRAQAKKM NVTNLRSNEA ETQRAEIRIA KTALVNVSLW FICWTPYAAI TIQGLLGNAE GITPLLTTLP ALLAKSCSCY NPFVYAISHP KFRLAITQHL PWFCVHEKDP NDVEENQSSN TQTQEKS // ID OPS2_SCHGR STANDARD; PRT; 380 AA. AC Q26495; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 07-FEB-2006, entry version 39. DE Opsin-2. GN Name=Lo2; OS Schistocerca gregaria (Desert locust). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Orthopteroidea; Orthoptera; Caelifera; Acridomorpha; OC Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca. OX NCBI_TaxID=7010; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=97301174; PubMed=9156194; DOI=10.1016/S0042-6989(96)00198-8; RA Towner P., Harris P., Wolstenholme A.J., Hill C., Worm K., Gartner W.; RT "Primary structure of locust opsins: a speculative model which may RT account for ultraviolet wavelength light detection."; RL Vision Res. 37:495-503(1997). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X80072; CAA56378.1; -; mRNA. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR000856; Opsin_RH3/RH4. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 380 Opsin-2. FT /FTId=PRO_0000197636. FT TOPO_DOM 1 51 Extracellular. FT TRANSMEM 52 76 1 (Potential). FT TOPO_DOM 77 88 Cytoplasmic. FT TRANSMEM 89 115 2 (Potential). FT TOPO_DOM 116 128 Extracellular. FT TRANSMEM 129 148 3 (Potential). FT TOPO_DOM 149 166 Cytoplasmic. FT TRANSMEM 167 191 4 (Potential). FT TOPO_DOM 192 215 Extracellular. FT TRANSMEM 216 243 5 (Potential). FT TOPO_DOM 244 279 Cytoplasmic. FT TRANSMEM 280 303 6 (Potential). FT TOPO_DOM 304 311 Extracellular. FT TRANSMEM 312 336 7 (Potential). FT TOPO_DOM 337 380 Cytoplasmic. FT BINDING 323 323 Retinal chromophore (covalent) (By FT similarity). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 125 202 Potential. SQ SEQUENCE 380 AA; 42531 MW; 113504F71027C07A CRC64; MVNTTDFYPV PAAMAYESSV GLPLLGWNVP TEHLDLVHPH WRSFQVPNKY WHFGLAFVYF MLMCMSSLGN GIVLWIYATT KSIRTPSNMF IVNLALFDVL MLLEMPMLVV SSLFYQRPVG WELGCDIYAA LGSVAGIGSA INNAAIAFDR YRTISCPIDG RLTQGQVLAL IAGTWVWTLP FTLMPLLRIW SRFTAEGFLT TCSFDYLTDD EDTKVFVGCI FAWSYAFPLC LICCFYYRLI GAVREHEKML RDQAKKMNVK SLQSNADTEA QSAEIRIAKV ALTIFFLFLC SWTPYAVVAM IGAFGNRAAL TPLSTMIPAV TAKIVSCIDP WVYAINHPRF RAEVQKRMKW LHLGEDARSS KSDTSSTATD RTVGNVSASA // ID OPS5_DROME STANDARD; PRT; 382 AA. AC P91657; P91671; Q9VKD1; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 04-APR-2006, entry version 49. DE Opsin Rh5. GN Name=Rh5; ORFNames=CG5279; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Canton-S; TISSUE=Retina; RX MEDLINE=97136782; PubMed=8982159; DOI=10.1016/S0896-6273(00)80243-3; RA Chou W.-H., Hall K.J., Wilson D.B., Wideman C.L., Townson S.M., RA Chadwell L.V., Britt S.G.; RT "Identification of a novel Drosophila opsin reveals specific RT patterning of the R7 and R8 photoreceptor cells."; RL Neuron 17:1101-1115(1996). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97307773; PubMed=9165115; RA Papatsenko D., Sheng G., Desplan C.; RT "A new rhodopsin in R8 photoreceptors of Drosophila: evidence for RT coordinate expression with Rh3 in R7 cells."; RL Development 124:1665-1673(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Head; RX MEDLINE=22426066; PubMed=12537569; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., RA Rubin G.M., Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed specifically in the retina. Each CC Drosophila eye is composed of 800 facets or ommatidia. Each CC ommatidium contains 8 photoreceptor cells (R1-R8), the R1 to R6 CC cells are outer cells, while R7 and R8 are inner cells. Rh5 is CC expressed only in the R8 cells of ommatidia in which Rh3 is CC expressed in the overlying R7 cells. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U67905; AAC47426.1; -; Genomic_DNA. DR EMBL; U80667; AAB38966.1; -; mRNA. DR EMBL; AE003634; AAF53145.1; -; Genomic_DNA. DR EMBL; AY069237; AAL39382.1; -; mRNA. DR UniGene; Dm.409; -. DR HSSP; P02699; 1F88. DR Ensembl; CG5279; Drosophila melanogaster. DR FlyBase; FBgn0014019; Rh5. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-008619-MONOMER; -. DR GO; GO:0016028; C:rhabdomere; IDA. DR GO; GO:0008020; F:G-protein coupled photoreceptor activity; IGI. DR GO; GO:0016038; P:absorption of visible light; IMP. DR GO; GO:0007602; P:phototransduction; IGI. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR000856; Opsin_RH3/RH4. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; Complete proteome; G-protein coupled receptor; KW Glycoprotein; Membrane; Phosphorylation; Photoreceptor protein; KW Receptor; Retinal protein; Sensory transduction; Transducer; KW Transmembrane; Vision. FT CHAIN 1 382 Opsin Rh5. FT /FTId=PRO_0000197633. FT TOPO_DOM 1 49 Extracellular. FT TRANSMEM 50 76 1 (Potential). FT TOPO_DOM 77 88 Cytoplasmic. FT TRANSMEM 89 112 2 (Potential). FT TOPO_DOM 113 127 Extracellular. FT TRANSMEM 128 147 3 (Potential). FT TOPO_DOM 148 165 Cytoplasmic. FT TRANSMEM 166 190 4 (Potential). FT TOPO_DOM 191 214 Extracellular. FT TRANSMEM 215 242 5 (Potential). FT TOPO_DOM 243 278 Cytoplasmic. FT TRANSMEM 279 302 6 (Potential). FT TOPO_DOM 303 310 Extracellular. FT TRANSMEM 311 335 7 (Potential). FT TOPO_DOM 336 382 Cytoplasmic. FT BINDING 322 322 Retinal chromophore (covalent) (By FT similarity). FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential). FT DISULFID 124 201 Potential. FT CONFLICT 21 22 SV -> RL (in Ref. 2). FT CONFLICT 56 56 Y -> N (in Ref. 2). FT CONFLICT 147 147 F -> S (in Ref. 2). FT CONFLICT 180 180 F -> W (in Ref. 2). FT CONFLICT 190 190 G -> D (in Ref. 2). FT CONFLICT 263 263 A -> P (in Ref. 2). SQ SEQUENCE 382 AA; 42705 MW; 722B4B40015345FE CRC64; MHINGPSGPQ AYVNDSLGDG SVFPMGHGYP AEYQHMVHAH WRGFREAPIY YHAGFYIAFI VLMLSSIFGN GLVIWIFSTS KSLRTPSNLL ILNLAIFDLF MCTNMPHYLI NATVGYIVGG DLGCDIYALN GGISGMGASI TNAFIAFDRY KTISNPIDGR LSYGQIVLLI LFTWLWATPF SVLPLFQIWG RYQPEGFLTT CSFDYLTNTD ENRLFVRTIF VWSYVIPMTM ILVSYYKLFT HVRVHEKMLA EQAKKMNVKS LSANANADNM SVELRIAKAA LIIYMLFILA WTPYSVVALI GCFGEQQLIT PFVSMLPCLA CKSVSCLDPW VYATSHPKYR LELERRLPWL GIREKHATSG TSGGQESVAS VSGDTLALSV QN // ID OPS4_DROME STANDARD; PRT; 378 AA. AC P08255; Q9VVB3; DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2000, sequence version 2. DT 04-APR-2006, entry version 64. DE Opsin Rh4 (Inner R7 photoreceptor cells opsin). GN Name=Rh4; ORFNames=CG9668; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=87197541; PubMed=2952772; RA Montell C., Jones K., Zuker C.S., Rubin G.M.; RT "A second opsin gene expressed in the ultraviolet-sensitive R7 RT photoreceptor cells of Drosophila melanogaster."; RL J. Neurosci. 7:1558-1566(1987). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- MISCELLANEOUS: Each Drosophila eye is composed of 800 facets or CC ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), CC the R1 to R6 cells are outer cells, while R7 and R8 are inner CC cells. CC -!- MISCELLANEOUS: Opsin Rh4 is sensitive to UV light. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M17730; AAA28856.1; -; Genomic_DNA. DR EMBL; M17719; AAA28856.1; JOINED; Genomic_DNA. DR EMBL; AE003526; AAF49400.1; -; Genomic_DNA. DR PIR; S28789; S28789. DR UniGene; Dm.4810; -. DR Ensembl; CG9668; Drosophila melanogaster. DR FlyBase; FBgn0003250; Rh4. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-017031-MONOMER; -. DR GO; GO:0008020; F:G-protein coupled photoreceptor activity; IDA. DR GO; GO:0007604; P:phototransduction, UV; IDA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR000856; Opsin_RH3/RH4. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; Complete proteome; G-protein coupled receptor; KW Glycoprotein; Membrane; Phosphorylation; Photoreceptor protein; KW Receptor; Retinal protein; Sensory transduction; Transducer; KW Transmembrane; Vision. FT CHAIN 1 378 Opsin Rh4. FT /FTId=PRO_0000197630. FT TOPO_DOM 1 53 Extracellular. FT TRANSMEM 54 78 1 (Potential). FT TOPO_DOM 79 90 Cytoplasmic. FT TRANSMEM 91 111 2 (Potential). FT TOPO_DOM 112 127 Extracellular. FT TRANSMEM 128 148 3 (Potential). FT TOPO_DOM 149 167 Cytoplasmic. FT TRANSMEM 168 192 4 (Potential). FT TOPO_DOM 193 216 Extracellular. FT TRANSMEM 217 244 5 (Potential). FT TOPO_DOM 245 280 Cytoplasmic. FT TRANSMEM 281 304 6 (Potential). FT TOPO_DOM 305 312 Extracellular. FT TRANSMEM 313 337 7 (Potential). FT TOPO_DOM 338 378 Cytoplasmic. FT BINDING 324 324 Retinal chromophore (covalent). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Probable). FT DISULFID 126 203 Potential. FT CONFLICT 111 112 Missing (in Ref. 1). FT CONFLICT 120 120 A -> AIY (in Ref. 1). FT CONFLICT 313 313 P -> Q (in Ref. 1). SQ SEQUENCE 378 AA; 42658 MW; 9A33C1E6F7BD11AD CRC64; MEPLCNASEP PLRPEARSSG NGDLQFLGWN VPPDQIQYIP EHWLTQLEPP ASMHYMLGVF YIFLFCASTV GNGMVIWIFS TSKSLRTPSN MFVLNLAVFD LIMCLKAPIF IYNSFHRGFA LGNTWCQIFA SIGSYSGIGA GMTNAAIGYD RYNVITKPMN RNMTFTKAVI MNIIIWLYCT PWVVLPLTQF WDRFVPEGYL TSCSFDYLSD NFDTRLFVGT IFFFSFVCPT LMILYYYSQI VGHVFSHEKA LREQAKKMNV ESLRSNVDKS KETAEIRIAK AAITICFLFF VSWTPYGVMS LIGAFGDKSL LTPGATMIPA CTCKLVACID PFVYAISHPR YRLELQKRCP WLGVNEKSGE ISSAQSTTTQ EQQQTTAA // ID OPSD_LOLFO STANDARD; PRT; 452 AA. AC P24603; DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-1992, sequence version 1. DT 07-FEB-2006, entry version 48. DE Rhodopsin. GN Name=RHO; OS Loligo forbesi (Northern European squid). OC Eukaryota; Metazoa; Mollusca; Cephalopoda; Coleoidea; Neocoleoidea; OC Decapodiformes; Loliginidae; Loligo. OX NCBI_TaxID=6618; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Retina; RX MEDLINE=91158727; PubMed=1900420; RA Hall M.D., Hoon M.A., Ryba N.J.P., Pottinger J.D.D., Keen J.N., RA Saibil H.R., Findlay J.B.C.; RT "Molecular cloning and primary structure of squid (Loligo forbesi) RT rhodopsin, a phospholipase C-directed G-protein-linked receptor."; RL Biochem. J. 274:35-40(1991). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. This receptor is coupled to the activation CC of phospholipase C. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Absorption: CC Abs(max)=494 nm; CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X56788; CAA40108.1; -; mRNA. DR PIR; S14332; S14332. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR006031; XYPPX. DR Pfam; PF00001; 7tm_1; 1. DR Pfam; PF02162; XYPPX; 8. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Lipoprotein; KW Membrane; Palmitate; Phosphorylation; Photoreceptor protein; Receptor; KW Retinal protein; Sensory transduction; Transducer; Transmembrane; KW Vision. FT CHAIN 1 452 Rhodopsin. FT /FTId=PRO_0000197732. FT TOPO_DOM 1 33 Extracellular (Potential). FT TRANSMEM 34 58 1 (Potential). FT TOPO_DOM 59 70 Cytoplasmic (Potential). FT TRANSMEM 71 97 2 (Potential). FT TOPO_DOM 98 111 Extracellular (Potential). FT TRANSMEM 112 131 3 (Potential). FT TOPO_DOM 132 151 Cytoplasmic (Potential). FT TRANSMEM 152 175 4 (Potential). FT TOPO_DOM 176 199 Extracellular (Potential). FT TRANSMEM 200 227 5 (Potential). FT TOPO_DOM 228 261 Cytoplasmic (Potential). FT TRANSMEM 262 285 6 (Potential). FT TOPO_DOM 286 294 Extracellular (Potential). FT TRANSMEM 295 318 7 (Potential). FT TOPO_DOM 319 452 Cytoplasmic (Potential). FT COMPBIAS 370 380 Met-rich. FT COMPBIAS 381 452 Gln/Pro-rich. FT BINDING 305 305 Retinal chromophore (covalent) (By FT similarity). FT LIPID 336 336 S-palmitoyl cysteine (By similarity). FT LIPID 337 337 S-palmitoyl cysteine (By similarity). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Probable). FT DISULFID 108 186 By similarity. SQ SEQUENCE 452 AA; 50576 MW; 6AA9E26DE4C4DFA4 CRC64; MGRDIPDNET WWYNPYMDIH PHWKQFDQVP AAVYYSLGIF IAICGIIGCV GNGVVIYLFT KTKSLQTPAN MFIINLAFSD FTFSLVNGFP LMTISCFMKY WVFGNAACKV YGLIGGIFGL MSIMTMTMIS IDRYNVIGRP MSASKKMSHR KAFIMIIFVW IWSTIWAIGP IFGWGAYTLE GVLCNCSFDY ITRDTTTRSN ILCMYIFAFM CPIVVIFFCY FNIVMSVSNH EKEMAAMAKR LNAKELRKAQ AGANAEMKLA KISIVIVTQF LLSWSPYAVV ALLAQFGPIE WVTPYAAQLP VMFAKASAIH NPMIYSVSHP KFRERIASNF PWILTCCQYD EKEIEDDKDA EAEIPAGEQS GGETADAAQM KEMMAMMQKM QAQQQQQPAY PPQGYPPQGY PPPPPQGYPP QGYPPQGYPP QGYPPPPQGP PPQGPPPQAA PPQGVDNQAY QA // ID OPN4_FELCA STANDARD; PRT; 487 AA. AC Q5YKK9; DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot. DT 23-NOV-2004, sequence version 1. DT 02-MAY-2006, entry version 15. DE Melanopsin (Opsin-4). GN Name=OPN4; OS Felis silvestris catus (Cat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=15842746; DOI=10.1017/S0952523805001069; RA Semo M., Munoz Llamosas M., Foster R.G., Jeffery G.; RT "Melanopsin (Opn4) positive cells in the cat retina are randomly RT distributed across the ganglion cell layer."; RL Vis. Neurosci. 22:111-116(2005). CC -!- FUNCTION: Light receptor required for regulation of circadian CC rhythm. Contributes to pupillar reflex and other non-image forming CC responses to light. May be able to isomerize covalently bound all- CC trans retinal back to 11-cis retinal (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. Found CC in soma, dendrites and proximal part of axons of certain retinal CC ganglion cells (By similarity). CC -!- TISSUE SPECIFICITY: Eye. Expression is restricted within the CC ganglion cell layer. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY382594; AAR36861.1; -; mRNA. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Membrane; KW Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane. FT CHAIN 1 487 Melanopsin. FT /FTId=PRO_0000226728. FT TOPO_DOM 1 67 Extracellular (Potential). FT TRANSMEM 68 88 1 (Potential). FT TOPO_DOM 89 102 Cytoplasmic (Potential). FT TRANSMEM 103 123 2 (Potential). FT TOPO_DOM 124 139 Extracellular (Potential). FT TRANSMEM 140 160 3 (Potential). FT TOPO_DOM 161 183 Cytoplasmic (Potential). FT TRANSMEM 184 204 4 (Potential). FT TOPO_DOM 205 233 Extracellular (Potential). FT TRANSMEM 234 254 5 (Potential). FT TOPO_DOM 255 291 Cytoplasmic (Potential). FT TRANSMEM 292 312 6 (Potential). FT TOPO_DOM 313 353 Extracellular (Potential). FT TRANSMEM 354 370 7 (Potential). FT TOPO_DOM 371 487 Cytoplasmic (Potential). FT BINDING 335 335 Retinal chromophore (covalent) (By FT similarity). FT DISULFID 138 216 Potential. SQ SEQUENCE 487 AA; 53681 MW; B867E24B4D322D57 CRC64; MNPPSGPRTQ EPSCVATPAS PSRWDGYRSS TSSLDQPLPI SPTAARAQAA AWIPFPTVDV PDHAHYTLGT VILLVGLTGI LGNLMVIYTF CRSRGLRTPA NMFIINLAVS DFFMSFTQAP VFFASSLHKR WLFGEAGCEF YAFCGALFGI TSMITLMAIA LDRYLVITHP LATIGVVSKR RAALVLLGVW LYALAWSLPP FFGWSAYVPE GLLTSCSWDY MSFTPSVRAY TMLLFCFVFF LPLLVIVYCY IFIFRAIRET GQALQTFRAC EGGGRSPRQR QRLQREWKMA KIELLVILLF VLSWAPYSIV ALMAFAGYAH VLTPYMNSVP AVIAKASAIH NPIIYAITHP KYRMAIAQHL PCLGVLLGVS GQHTGPYASY RSTHRSTLSS QASDLSWISG RRRQASLGSE SEVGWMDTEA AAVWGAAQQV SGRFPCSQGL EDREAKAPVR PQGREAETPG QAMTMAMAPW DTPANCELPL HPGWAFH // ID OPSD2_PATYE STANDARD; PRT; 399 AA. AC O15974; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 07-FEB-2006, entry version 36. DE Rhodopsin, G0-coupled (G0-rhodopsin). GN Name=SCOP2; OS Patinopecten yessoensis (Ezo giant scallop) (Yesso scallop). OC Eukaryota; Metazoa; Mollusca; Bivalvia; Pteriomorphia; Pectinoida; OC Pectinoidea; Pectinidae; Mizuhopecten. OX NCBI_TaxID=6573; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Eye; RX MEDLINE=97435252; PubMed=9287291; DOI=10.1074/jbc.272.37.22979; RA Kojima D., Terakita A., Ishikawa T., Tsukahara Y., Maeda A., RA Shichida Y.; RT "A novel Go-mediated phototransduction cascade in scallop visual RT cells."; RL J. Biol. Chem. 272:22979-22989(1997). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to cis-retinal. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Retina. Expressed in the hyperpolarizing cell CC layer of the photoreceptor cells with its photoreceptive region CC adjacent to the lens. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB006455; BAA22218.1; -; mRNA. DR HSSP; P02699; 1F88. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR002962; Peropsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01244; PEROPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Membrane; KW Phosphorylation; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane; Vision. FT CHAIN 1 399 Rhodopsin, G0-coupled. FT /FTId=PRO_0000197736. FT TOPO_DOM 1 17 Extracellular. FT TRANSMEM 18 43 1 (Potential). FT TOPO_DOM 44 55 Cytoplasmic. FT TRANSMEM 56 81 2 (Potential). FT TOPO_DOM 82 95 Extracellular. FT TRANSMEM 96 115 3 (Potential). FT TOPO_DOM 116 134 Cytoplasmic. FT TRANSMEM 135 158 4 (Potential). FT TOPO_DOM 159 182 Extracellular. FT TRANSMEM 183 210 5 (Potential). FT TOPO_DOM 211 240 Cytoplasmic. FT TRANSMEM 241 263 6 (Potential). FT TOPO_DOM 264 271 Extracellular. FT TRANSMEM 272 295 7 (Potential). FT TOPO_DOM 296 399 Cytoplasmic. FT BINDING 282 282 Retinal chromophore (covalent). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT DISULFID 92 169 By similarity. SQ SEQUENCE 399 AA; 45097 MW; 5AA6857ABC912100 CRC64; MPFPLNRTDT ALVISPSEFR IIGIFISICC IIGVLGNLLI IIVFAKRRSV RRPINFFVLN LAVSDLIVAL LGYPMTAASA FSNRWIFDNI GCKIYAFLCF NSGVISIMTH AALSFCRYII ICQYGYRKKI TQTTVLRTLF SIWSFAMFWT LSPLFGWSSY VIEVVPVSCS VNWYGHGLGD VSYTISVIVA VYVFPLSIIV FSYGMILQEK VCKDSRKNGI RAQQRYTPRF IQDIEQRVTF ISFLMMAAFM VAWTPYAIMS ALAIGSFNVE NSFAALPTLF AKASCAYNPF IYAFTNANFR DTVVEIMAPW TTRRVGVSTL PWPQVTYYPR RRTSAVNTTD IEFPDDNIFI VNSSVNGPTV KREKIVQRNP INVRLGIKIE PRDSRAATEN TFTADFSVI // ID OPN5_HUMAN STANDARD; PRT; 353 AA. AC Q6U736; Q5T5B9; Q5T886; Q7Z603; Q86SL5; DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 07-JUN-2005, sequence version 2. DT 18-APR-2006, entry version 18. DE Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein DE coupled receptor PGR12) (Transmembrane protein 13). GN Name=OPN5; Synonyms=GPR136, PGR12, TMEM13; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX MEDLINE=22985418; PubMed=14623103; DOI=10.1016/S0014-5793(03)01212-2; RA Tarttelin E.E., Bellingham J., Hankins M.W., Foster R.G., Lucas R.J.; RT "Neuropsin (Opn5): a novel opsin identified in mammalian neural RT tissue."; RL FEBS Lett. 554:410-416(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=22985413; PubMed=14623098; DOI=10.1016/S0014-5793(03)01196-7; RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., RA Schioeth H.B.; RT "Seven evolutionarily conserved human rhodopsin G protein-coupled RT receptors lacking close relatives."; RL FEBS Lett. 554:381-388(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-231. RX MEDLINE=22584407; PubMed=12679517; DOI=10.1073/pnas.0230374100; RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., RA Bergmann J.E., Gaitanaris G.A.; RT "The G protein-coupled receptor repertoires of human and mouse."; RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Detected in brain and retina and cell lines CC derived from neural retina. CC -!- PTM: It is uncertain whether Cys-315 or Cys-316 is palmitoylated. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY377391; AAR21109.1; -; mRNA. DR EMBL; AY288419; AAP72128.1; -; mRNA. DR EMBL; AY255615; AAO85127.1; -; mRNA. DR EMBL; AL356421; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL161622; CAI20454.1; -; Genomic_DNA. DR UniGene; Hs.213717; -. DR Ensembl; ENSG00000124818; Homo sapiens. DR HGNC; HGNC:19992; OPN5. DR MIM; 609042; gene. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR InterPro; IPR002962; Peropsin. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01244; PEROPSIN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; G-protein coupled receptor; Glycoprotein; Lipoprotein; KW Membrane; Palmitate; Photoreceptor protein; Receptor; Retinal protein; KW Sensory transduction; Transducer; Transmembrane. FT CHAIN 1 353 Opsin-5. FT /FTId=PRO_0000197817. FT TOPO_DOM 1 33 Extracellular (Potential). FT TRANSMEM 34 54 1 (Potential). FT TOPO_DOM 55 74 Cytoplasmic (Potential). FT TRANSMEM 75 95 2 (Potential). FT TOPO_DOM 96 108 Extracellular (Potential). FT TRANSMEM 109 129 3 (Potential). FT TOPO_DOM 130 150 Cytoplasmic (Potential). FT TRANSMEM 151 171 4 (Potential). FT TOPO_DOM 172 197 Extracellular (Potential). FT TRANSMEM 198 218 5 (Potential). FT TOPO_DOM 219 252 Cytoplasmic (Potential). FT TRANSMEM 253 273 6 (Potential). FT TOPO_DOM 274 288 Extracellular (Potential). FT TRANSMEM 289 309 7 (Potential). FT TOPO_DOM 310 353 Cytoplasmic (Potential). FT BINDING 296 296 Retinal chromophore (covalent). FT LIPID 315 315 S-palmitoyl cysteine (Potential). FT LIPID 316 316 S-palmitoyl cysteine (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT DISULFID 106 183 Potential. FT CONFLICT 84 86 Missing (in Ref. 2). FT CONFLICT 133 145 Missing (in Ref. 3). FT CONFLICT 353 353 V -> WE (in Ref. 1). SQ SEQUENCE 353 AA; 39511 MW; A18FA2C07410058E CRC64; MALNHTALPQ DERLPHYLRD GDPFASKLSW EADLVAGFYL TIIGILSTFG NGYVLYMSSR RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV FGWIGCRWYG WAGFFFGCGS LITMTAVSLD RYLKICYLSY GVWLKRKHAY ICLAAIWAYA SFWTTMPLVG LGDYVPEPFG TSCTLDWWLA QASVGGQVFI LNILFFCLLL PTAVIVFSYV KIIAKVKSSS KEVAHFDSRI HSSHVLEMKL TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM YNPIIYQVID YKFACCQTGG LKATKKKSLE GFRLHTVTTV RKSSAVLEIH EEV // ID REIS_TODPA STANDARD; PRT; 301 AA. AC P23820; DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1991, sequence version 1. DT 07-FEB-2006, entry version 38. DE Retinochrome (Retinal photoisomerase). OS Todarodes pacificus (Japanese flying squid). OC Eukaryota; Metazoa; Mollusca; Cephalopoda; Coleoidea; Neocoleoidea; OC Decapodiformes; Oegopsida; Ommastrephidae; Todarodes. OX NCBI_TaxID=6637; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Retina; RX MEDLINE=91032043; PubMed=2226795; DOI=10.1016/0014-5793(90)80383-T; RA Hara-Nishimura I., Matsumoto T., Mori H., Nishimura M., Hara R., RA Hara T.; RT "Cloning and nucleotide sequence of cDNA for retinochrome, retinal RT photoisomerase from the squid retina."; RL FEBS Lett. 271:106-110(1990). RN [2] RP PROTEIN SEQUENCE OF 1-15 AND 114-128. RC TISSUE=Retina; RA Uematsu J., Hara-Nishimura I., Wada K., Matsubara H., Hara T.; RT "Amino-terminal sequence of squid retinochrome."; RL Photobiochem. Photobiophys. 13:197-201(1986). RN [3] RP PROTEIN SEQUENCE OF 274-281, AND RETINAL-BINDING SITE. RC TISSUE=Retina; RX MEDLINE=94063090; PubMed=8243675; DOI=10.1016/0014-5793(93)80447-3; RA Hara-Nishimura I., Kondo M., Nishimura M., Hara R., Hara T.; RT "Amino acid sequence surrounding the retinal-binding site in RT retinochrome of the squid, Todarodes pacificus."; RL FEBS Lett. 335:94-98(1993). CC -!- FUNCTION: Retinochrome is capable of acting as an effective CC catalyst in the light to convert various isomers of retinal into CC 11-cis, the form that is required by opsin to resynthesize CC rhodopsin. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. Myeloid membrane. CC -!- TISSUE SPECIFICITY: Mainly stored in myeloid bodies of the inner CC segments. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X57143; CAA40422.1; -; mRNA. DR PIR; S12864; S12864. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR001760; Opsin. DR Pfam; PF00001; 7tm_1; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. KW Chromophore; Direct protein sequencing; G-protein coupled receptor; KW Glycoprotein; Membrane; Photoreceptor protein; Receptor; KW Retinal protein; Sensory transduction; Transducer; Transmembrane; KW Vision. FT CHAIN 1 301 Retinochrome. FT /FTId=PRO_0000197812. FT TOPO_DOM 1 17 Extracellular (Potential). FT TRANSMEM 18 43 1 (Potential). FT TOPO_DOM 44 54 Cytoplasmic (Potential). FT TRANSMEM 55 76 2 (Potential). FT TOPO_DOM 77 94 Extracellular (Potential). FT TRANSMEM 95 120 3 (Potential). FT TOPO_DOM 121 132 Cytoplasmic (Potential). FT TRANSMEM 133 153 4 (Potential). FT TOPO_DOM 154 180 Extracellular (Potential). FT TRANSMEM 181 208 5 (Potential). FT TOPO_DOM 209 230 Cytoplasmic (Potential). FT TRANSMEM 231 255 6 (Potential). FT TOPO_DOM 256 264 Extracellular (Potential). FT TRANSMEM 265 289 7 (Potential). FT TOPO_DOM 290 301 Cytoplasmic (Potential). FT BINDING 275 275 Retinal chromophore (covalent). FT CARBOHYD 170 170 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 301 AA; 33490 MW; CBB37317486B27FC CRC64; MFGNPAMTGL HQFTMWEHYF TGSIYLVLGC VVFSLCGMCI IFLARQSPKP RRKYAILIHV LITAMAVNGG DPAHASSSIV GRWLYGSVGC QLMGFWGFFG GMSHIWMLFA FAMERYMAVC HREFYQQMPS VYYSIIVGLM YTFGTFWATM PLLGWASYGL EVHGTSCTIN YSVSDESYQS YVFFLAIFSF IFPMVSGWYA ISKAWSGLSA IPDAEKEKDK DILSEEQLTA LAGAFILISL ISWSGFGYVA IYSALTHGGA QLSHLRGHVP PIMSKTGCAL FPLLIFLLTA RSLPKSDTKK P //