Supplementary figure 1: The template multiple alignments of the 28 vertebrate olfactory receptors (plus one outgroup sequence OPSD_BOVIN; a.) and the 23 lipocalin sequences (b). On top of each alignment the invariable arrays used with indel-Seq-Gen are shown. The GPCR invariable array contains the motif patterns (shown with '1', '2', and '3') identified by Fuchs et al. (2001). a. 000000000000000000000000000000000000000000000000000000002000 OR4C6_HUMAN ------------------ENQN--NV--TEF--ILLGLTENLELWK-IFSAVFLVMYVAT OR4N4_HUMAN ----------------KIANNT--VV--TEF--ILLGLTQSQDIQL-LVFVLILIFYLII O12D3_HUMAN ------------------ENVT--TM--NEF--LLLGLTGVQELQP-FFFGIFLIIYLIN O12D2_HUMAN ------------------LNTT--SV--TEF--LLLGVTDIQELQP-FLFVVFLTIYFIS O1078_RAT ----------------DSSNRT--RV--SEF--LLLGFVENKDLQP-LIYGLFLSMYLVT OR7AH_HUMAN ----------------EPENDT--GI--SEF--VLLGLSEEPELQP-FLFGLFLSMYLVT OR1G1_PANTR ----------------EGKNLT--SI--SEF--FLLGFSEQLEEQK-ALFGSFLFMYLVM OLFI8_RAT ------------------NNKT--VI--THF--LLLGLPIPPEHQQ-LFFALFLIMYLTT OR6J1_HUMAN ------------------GNWT-AAV--TEF--VLLGFSLSREVEL-LLLVLLLPTFLLT OL287_RAT -------------AWSTGQNLS--TP--GPF--ILLGFPGPRSMRI-GLFLLFLVMYLLT O11A1_HUMAN -------------EIVSTGNET---I--TEF--VLLGFYDIPELHF-LFFIVFTAVYVFI O11H6_HUMAN FFIIHSLVTSVFLTALGPQNRTMHFV--TEF--VLLGFHGQREMQS-CFFSFILVLYLLT O10K1_HUMAN ----------------EQVNKT--VV--REF--VVLGFSSLARLQQ-LLFVIFLLLYLFT OR2K1_HUMAN ----------------QGENFT--IW--SIF--FLEGFSQYPGLEV-VLFVFSLVMYLTT O13C3_HUMAN ----------------GEINQT--LV--SEF--LLLGLSGYPKIEI-VYFALILVMYLVI OR2F1_HUMAN ----------------GTDNQT--WV--SEF--ILLGLSSDWDTRV-SLFVLFLVMYVVT O2A12_HUMAN -----------------ESNQT--WI--TEV--ILLGFQVDPALEL-FLFGFFLLFYSLT OR9G1_HUMAN ----------------QRSNHT---V--TEF--ILLGFTTDPGMQL-GLFVVFLGVYSLT OR9G5_HUMAN ----------------QRSNHT---V--TEF--ILLGFTTDPGMQL-GLFVVFLGVYSLT OLF2_CANFA ----------------DGKNCS--SV--NEF--LLVGISNKPGVKV-TLFITFLIVYLII O1044_MOUSE ----------------AQINCT--QV--TEF--ILVGLTDREELKM-PLFVVFLSIYLFT OR8D2_HUMAN ----------------ATSNHS--SG--AEF--ILAGLTQRPELQL-PLFLLFLGIYVVT OL502_MOUSE -------------AFLEDGNHT--AV--TGF--ILLGLTDDPVLRV-VLFVIILCIYLVT OR3A3_PANTR -------------ESEAGTNRT--AV--AEF--MLLGLVQTEEMQS-VIFVLLLFAYLVT OR3A1_HUMAN -------------QPESGANGT--VI--AEF--ILLGLLEAPGLQP-VVFVLFLFAYLVT O10AD_HUMAN -----------------LRNGS--IV--TEF--ILVGFQQSSTSTRALLFALFLALYSLT O56A4_HUMAN ---------------ASPNNDSTAPV--SEF--LLICFPNFQSWQH-WLSLPLSLLFLLA O51A4_HUMAN ----------------SIINTSYVEI--TTF--FLVGMPGLEYAHI-WISIPICSMYLIA OPSD_BOVIN ------NGTEGPNFYVPFSNKT--GVVRSPFEAPQYYLAEPWQFSM-----LAAYMFLLI 002000200000000000000000000000001000200000000100000000000000 OR4C6_HUMAN VLE---NLLIV-VTIITSQSLRS-PMYFFLTFLSLLDVMFSSVVAPKVIVDTLSKSTTIS OR4N4_HUMAN LPG---NFLII-FTIRSDPGL-TAPLYFFLGNLAFLDASYSFIVAPRMLVDFFSEKKVIS O12D3_HUMAN LIG---NGSIL-VMVVLEPQLHS-PMYFFLGNLSCLDISYSSVTLPKLLVNLVCSRRAIS O12D2_HUMAN VTG---NGAVL-MIVISDPRLHS-LMYFFLGNLSYLDICYSTVTLPKMLQNFLSTHKAIS O1078_RAT VIG---NISII-VAIISDPCLHT-PMYFFLSNLSFVDICFISTTVPKMLVNIQTQNNVIT OR7AH_HUMAN VLG---NLLII-LATISDSHLHT-PMYFFLSNLSFADICFISTTIPKMLINIQTQSRVIT OR1G1_PANTR VAG---NLLII-LVIITDTQLHT-PMYFFLANLSLADACFVSTTVPKMLANIQIQSQAIS OLFI8_RAT FLG---NLLIV-VLVQLDSHLHT-PMYLFLSNLSFSDLCFSSVTMLKLLQNIQSQVPSIS OR6J1_HUMAN LLG---NLLII-STVLSCSRLHT-PMYFFLCNLSILDILFTSVISPKVLANLGSRDKTIS OL287_RAT VVG---NLAII-SLVGAHRCLQT-PMYFFLCNLSFLEIWFTTACVPKTLATFAPRGGVIS O11A1_HUMAN IIG---NMLII-VAVVSSQRLHK-PMYIFLANLSFLDILYTSAVMPKMLEGFL-QEATIS O11H6_HUMAN LLG---NGAIV-CAVKLDRRLHT-PMYILLGNFAFLEIWYISSTVPNMLVNILSEIKTIS O10K1_HUMAN LGT---NAIII-STIVLDRALHT-PMYFFLAILSCSEICYTFVIVPKMLVDLLSQKKTIS OR2K1_HUMAN LLG---NSTLI-LITILDSRLKT-PMYLFLGNLSFMDICYTSASVPTLLVNLLSSQKTII O13C3_HUMAN LIG---NGVLI-IASIFDSHFHT-PMYFFLGNLSFLDICYTSSSVPSTLVSLISKKRNIS OR2F1_HUMAN VLG---NCLIV-LLIRLDSRLHT-PMYFFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIP O2A12_HUMAN LMG---NGIIL-GLIYLDSRLHT-PMYVFLSHLAIVDMSYASSTVPKMLANLVMHKKVIS OR9G1_HUMAN VVG---NSTLI-VLICNDSCLHT-PMYFFTGNLSFLDLWYSSVYTPKILVTCISEDKSIS OR9G5_HUMAN VVG---NSTLI-VLICNDSHLHT-PMYFVVGNLSFLDLWYSSVYTPKILVICISEDKSIS OLF2_CANFA LVA---NLGMI-ILIRMDSQLHT-PMYFFLSHLSFSDARYSTAVGPRMLVGFIAKNKSIP O1044_MOUSE TLG---NLGLI-LVIRTDARLHT-PMYFFLSNLAFVDFCYSSVITPKMLGNFLYKQNMIS OR8D2_HUMAN VVG---NLGMI-FLIALSSQLYP-PVYYFLSHLSFIDLCYSSVITPKMLVNFVPEENIIS OL502_MOUSE VSG---NLSTI-LLIRVSSQLHH-PMYFFLSHLASADIGYSSSVTPNMLVNFLVERNTIS OR3A3_PANTR TGG---NLSIL-AAILVEPKLHT-PMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTIS OR3A1_HUMAN VRG---NLSIL-AAVLVEPKLHT-PMYFFLGNLSVLDVGCISVTVPSMLSRLLSRKRAVP O10AD_HUMAN MAM---NGLIIFITSWTDPKLNS-PMYFFLGHLSLLDVCFITTTIPQMLIHLVVRDHIVS O56A4_HUMAN MGA---NTTLL-ITIQLEASLHQ-PLYYLLSLLSLLDIVLCLTVIPKVLAIFWFDLRSIS O51A4_HUMAN ILG---NGTIL-FIIKTEPSLHE-PMYYFLSMLAMSDLGLSLSSLPTVLSIFLFNAPEIS OPSD_BOVIN MLGFPINFLTLYVTVQ-HKKLRT-PLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFG 000100100000000000000000333322222300101000000000000000001000 OR4C6_HUMAN LKGCLTQLFVEHFFGGVGIILLTVMAYDRYVAICKPLHYTIIMSPR-VCCLMVGGAWV-G OR4N4_HUMAN YRGCITQLFFLHFLGGGEGLLLVVMAFDRYIAICRPLHCSTVMNPR-ACYAMMLALWL-G O12D3_HUMAN FLGCITQLHFFHFLGSTEAILLAIMAFDRFVAICNPLRYTVIMNPQ-VCILLAAAAWL-I O12D2_HUMAN FLGCISQLHFFHFLGSTESMLFAVMAFDLSVAICKPLRYTVIMNPQ-LCTQMAITIWV-I O1078_RAT YAGCITQIYFFLLFVELDNFLLTIMAYDRYVAICHPMHYTVIMNYK-LCGFLVLVSWI-V OR7AH_HUMAN YAGCITQMCFFVLFGGLDSLLLAVMAYDRFVAICHPLHYTVIMNPR-LCGLLVLASWM-I OR1G1_PANTR YSGCLLQLYFFMLFVMLEAFLLAVMAYDHYVAICHPLHYILIMSPG-LCVFLVSASWI-M OLFI8_RAT YAGCLTQIFFFLLFGYLGNFLLVAMAYDRYVAICFPLHYTNIMSHK-LCTCLLLVFWI-M OR6J1_HUMAN FAGCITQCYFYFFLGTVEFLLLTVMSYDRYATICCPLRYTTIMRPS-VCIGTVVFSWV-G OL287_RAT LAGCATQMYFVFSLGCTEYFLLAVMAYDRYLAICLPLRYGGIMTPG-LAMRLALGSWL-C O11A1_HUMAN VAGCLLQFFIFGSLATAECLLLAVMAYDRYLAICYPLHYPLLMGPR-RYMGLVVTTWL-S O11H6_HUMAN FSGCFLQFYFFFSLGTTECFFLSVMAYDRYLAICRPLHYPSIMTGK-FCIILVCVCWV-G O10K1_HUMAN FLGCAIQMFSFLFFGSSHSFLLAAMGYDRYMAICNPLRYSVLMGHG-VCMGLMAAACA-C OR2K1_HUMAN FSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYSIIMNRC-VCARMATVSWV-T O13C3_HUMAN FSGCAVQMFFGFAMGSTECLLLGMMAFDRYVAICNPLRYPIILSKV-AYVLMASVSWL-S OR2F1_HUMAN FQSCAAQLFFSLALGGIEFVLLAVMAYDRYVAVCDALRYSAIMHGG-LCARLAITSWV-S O2A12_HUMAN FAPCILQTFLYLAFAITECLILVMMCYDRYVAICHPLQYTLIMNWR-VCTVLASTCWI-F OR9G1_HUMAN FAGCLCQFFFSAGLAYSECYLLAAVAYDRYVAISKPLLYAQAMSIK-LCALLVAVSYC-G OR9G5_HUMAN FAGCLCQFFFSAGLAYSECCLLAAMAYDRYVAISKPLLYAQAMSIK-LCALLVAVSYC-G OLF2_CANFA FYSCAMQWLVFCTFVDSECLLLAVMAFDRYKAISHPLLYTVSMSSR-VCSLLMAGVYL-V O1044_MOUSE FNACAAQLGCFLAFMTAECLLLASMAYDRYVAICNPLLYMVLMSPG-ICFQLVAAPYS-Y OR8D2_HUMAN FLECITQLYFFLIFVIAEGYLLTAMEYDRYVAICRPLLYNIVMSHR-VCSIMMAVVYS-L OL502_MOUSE YLGCGIQLGSAVFFGTVECFLLAAMAYDRFIAICSPLLYSNKMSTQ-VCVQLLVGSYI-G OR3A3_PANTR YDACLSQLFFFHLLAGMDCFLLTAMAYDRFLAICRPLTYSTHMNQR-VQRMLVAVSWT-C OR3A1_HUMAN CGACLTQLFFFHLFVGVDCFLLTAMAYDQFLAICRPLTYSTRMSQT-VQRMLVAASWA-C O10AD_HUMAN FVCCMTQMYFVFCVGVAECILLAFMAYDRYVAICYPLNYVPIISQK-VCVRLVGTAWF-F O56A4_HUMAN FPACFLQMFIMNSFLTMESCTFMVMAYDRYVAICHPLRYPSIITDQFVARAVVFVI-ARN O51A4_HUMAN SNACFAQEFFIHGFSVLESSVLLIMSFDRFLAIHNPLRYTSILTTV--RVAQIGIVFSFK OPSD_BOVIN PTGCNLEGFFATLGGEIALWSLVVLA-ERYVVVCKPMSNFRFGENH--AIMGVAFTWV-M 000000000000000000000000010000000001000000000100000000000000 OR4C6_HUMAN GFMHAMI--QLLFMYQ---IP---FCGPNIIDHFICDLFQLLTLACTDTHILGLLVTLNS OR4N4_HUMAN GFVHSII--QVVLILR---LP---FCGPNQLDNFFCDVRQVIKLACTDMFVVELLMVFNS O12D3_HUMAN SFFYALM--HSVMTAH---LS---FCGSQKLNHFFYDVKPLLELACSDTLLNQWLLSIVT O12D2_HUMAN GFFHALL--HSVMTSR---LN---FCGSNRIHHFLCDIKPLLKLACGNTELNQWLLSTVT O1078_RAT SVLHALF--QSLMMLA---LP---FCTHLEIPHYFCEPNQVIQLTCSDAFLNDLVIYFTL OR7AH_HUMAN AALNSLS--QSLMVLW---LS---FCTDLEIPHFFCELNQVIHLACSDTFLNDMGMYFAA OR1G1_PANTR NALYSLL--HTLLMNS---LS---FCANHEIPHFFCDIDPLLSLSCADPFTNELVIFITG OLFI8_RAT TSSHAMM--HTLLAAR---LS---FCENNVLLNFFCDLFVLLKLACSDTYVNELMIHIMG OR6J1_HUMAN GFLSVLF--PTILISQ---LP---FCGSNIINHFFCDSGPLLALACADTTAIELMDFMLS OL287_RAT GFSAITV--PATLIAR---LS---FCGSRVINHFFCDISPWIVLSCTDTQVVELVSFGIA O11A1_HUMAN GFVVDGL--VVALVAQ---LR---FCGPNHIDQFYCDFMLFVGLACSDPRVAQVTTLILS O11H6_HUMAN GFLCYPV--PIVLISQ---LP---FCGPNIIDHLVCDPGPLFALACISAPSTELICYTFN O10K1_HUMAN GFTVSLV--TTSLVFH---LP---FHSSNQLHHFFCDISPVLKLASQHSGFSQLVIFMLG OR2K1_HUMAN GCLTALL--ETSFALQ---IP---LCG-NLIDHFTCEILAVLKLACTSSLLMNTIMLVVS O13C3_HUMAN GGINSAV--QTLLAMR---LP---FCGNNIINHFACEILAVLKLACADISLNIITMVISN OR2F1_HUMAN GFISSPV--QTAITFQ---LP---MCRNKFIDHISCELLAVVRLACVDTSSNEVTIMVSS O2A12_HUMAN SFLLALV-QHITLILR---LP---FCGPQKINHFFCQIMSVFKLACADTRLN-VVLFAGS OR9G1_HUMAN GFINSSI--ITKKTFS---FN---FCRENIIDDFFCDLLPLVELACGEKGGYKIMMYFLL OR9G5_HUMAN GFINSSI--ITKKTFS---FN---FCRENIIDDFFCDLLPLVELACGEKGGYKIMMYFLL OLF2_CANFA GIMDASV--NTILTFR---LC---FCESNVINHFFCDVPPLLLLSCSDTQVNELVIFTIF O1044_MOUSE SFLVALF--HAILTFR---LC---YCHSNAINHFYCDDMPLLRLTCSDTHSKQLWIFVCA OR8D2_HUMAN GFLWATV--HTTRMSV---LS---FCRSHTVSHYFCDILPLLTLSCSSTHINEILLFIIG OL502_MOUSE GFLNASS--FTLSFFS---LV---FCGPNRVNHFFCDFAPLVKLSCSDVSVPAVVPSFTA OR3A3_PANTR AFTNALT--HTIALTT---LN---FCGPSVINHFYCDLPQLFQLSCSSTQLNELLLFVAA OR3A1_HUMAN AFTNALT--HTVAMST---LN---FCGPNVINHFYCDLPQLFQLSCSSTQLNELLLFAVG O10AD_HUMAN GLINGIF--LEYISFR---EP---FRRDNHIESFFCEAPIVIGLSCGDPQFSLWAIFADA O56A4_HUMAN AFVSLP---VPMLSAR---LR---YCAGNIIKNCICSNLSVSKLSCDDITFNQLYQFVAG O51A4_HUMAN SMLLVLP---FPFTLR--NLR---YCKKNQLSHSYCLHQDVMKLACSDNRID-VIYGFFG OPSD_BOVIN ALACAAPP----LVGWSRYIPEGMQC--------SCGIDYYTP---HEETNNESFVIYMF 000000020000032000000000000000000000010000000000000020000032 OR4C6_HUMAN GMMCVAIFLILIASYT-VILCS-----LKSYSSKGRHKLLVTLNSGMMCVAIFLILIASY OR4N4_HUMAN GLMTLLCFLGLLASYA-VILC-----HVRRAASEGKNKLLMVFNSGLMTLLCFLGLLASY O12D3_HUMAN GSISMGAFFLTLLSCFYVIGFL----LFKNRSCRILHKWLLSIVTGSISMGAFFLTLLSC O12D2_HUMAN GTIAMGPFFLTLLSYFYIITYL----FFKTRSCSMLCKWLLSTVTGTIAMGPFFLTLLSY O1078_RAT VLLATVPLAGIFYSYFKIVSSI-----CAISSVHGKYKLVIYFTLVLLATVPLAGIFYSY OR7AH_HUMAN GLLAGGPLVGILCSYSKIVSSI-----RAISSAQGKYKMGMYFAAGLLAGGPLVGILCSY OR1G1_PANTR GLTGLICVLCLIISYTNVFSTI-----LKIPSAQGKRKLVIFITGGLTGLICVLCLIISY OLFI8_RAT VIIIVIPFVLIVISYAKIISSI-----LKVPSTQSIHKLMIHIMGVIIIVIPFVLIVISY OR6J1_HUMAN SMVILCCIVLVAYSYTYIILTI-----VRIPSASGRKKLMDFMLSSMVILCCIVLVAYSY OL287_RAT FCVILGSCGITLVSYAYIITTI-----IKIPSARGRHRLVSFGIAFCVILGSCGITLVSY O11A1_HUMAN VFCLTIPFGLILTSYARIVVAV-----LRVPAGASRRRVTTLILSVFCLTIPFGLILTSY O11H6_HUMAN SMIIFGPFLSILGSYTLVIRAV-----LCIPSGAGRTKLICYTFNSMIIFGPFLSILGSY O10K1_HUMAN VFALVIPLLLILVSYIRIISAI-----LKIPSSVGRYKLVIFMLGVFALVIPLLLILVSY OR2K1_HUMAN ILLLPIPMLLVCISYIFILSTI-----LRITSAEGRNKTIMLVVSILLLPIPMLLVCISY O13C3_HUMAN MAFLVLPLMVIFFSYMFILYTI-----LQMNSATGRRKITMVISNMAFLVLPLMVIFFSY OR2F1_HUMAN IVLLMTPFCLVLLSYIQIISTI-----LKIQSREGRKKVTIMVSSIVLLMTPFCLVLLSY O2A12_HUMAN AFILVGPLCLVLVSYLHILVAI-----LRIQSGEGRRKVVLFAGSAFILVGPLCLVLVSY OR9G1_HUMAN ASNVICPAVLILASYLFIITSV-----LRISSSKGYLKIMMYFLLASNVICPAVLILASY OR9G5_HUMAN ASNVICPAVLILASYLFIITSV-----LRISSSKGYLKIMMYFLLASNVICPAVLILASY OLF2_CANFA GFIELITLSGLFVSYCYIILAV-----RKINSAEGRFKLVIFTIFGFIELITLSGLFVSY O1044_MOUSE GIMFISSLLIVFISYTFIISAI-----LRMRSAEGRRKLWIFVCAGIMFISSLLIVFISY OR8D2_HUMAN GVNTLATTLAVLISYAFIFSSI-----LGIHSTEGQSKILLFIIGGVNTLATTLAVLISY OL502_MOUSE GSIIIVTIFVIAVSYIYILITI-----LKMRSTEGRQKVVPSFTAGSIIIVTIFVIAVSY OR3A3_PANTR AVMAVAPLVFISVSYAHVVAAV-----LQIHSAEGRKKLLLFVAAAVMAVAPLVFISVSY OR3A1_HUMAN FIMAGTPMALIVISYIHVAAAV-----LRIRSVEGRKKLLLFAVGFIMAGTPMALIVISY O10AD_HUMAN IVVILSPMVLTVTSYVHILATI-----LSKASSSGRGKWAIFADAIVVILSPMVLTVTSY O56A4_HUMAN WTLLGSDLILIVISYSFILKVV-----LRIKAEGAVAKLYQFVAGWTLLGSDLILIVISY O51A4_HUMAN ALCLMVDFILIAVSYTLILKTV-----LGIASKKEQLKVIYGFFGALCLMVDFILIAVSY OPSD_BOVIN VVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESAT-TQKSFVIYMFVVHFIIPLIVIFFCY 000000000000000000000000000000000000000003300320000000000000 OR4C6_HUMAN T---MRPVVTHPI--DK-----------AMAVSDSIITPMLNPLIYTLRNAEVKSA-MKK OR4N4_HUMAN A---MCP--FRALPADK-----------MVSLFHTVIFPLMNPMIYTLRNQEVKTS-MKR O12D3_HUMAN FY--IRPASATSMIQDR-----------IMAIMYSAVTPVLNPLIYTLRNKEVMMA-LKK O12D2_HUMAN FY--IHPALESFMDQDR-----------IVAIMYTVVTPVLNPLIYTLRNKEVKGA-LGR O1078_RAT FK--LSSAANNSSQASA-----------TASVMYTVVTPMVNPFIYSLRNKDVKSV-LKK OR7AH_HUMAN SK--LTSAATHNSHTSA-----------TASVMYTVATPMLNPFIYSLRNKDIKRA-LKM OR1G1_PANTR TN--FSPPSTRXA--QK----DT-----VASVMYTVVTPMLNPFIYSLRNQEIKSS-LRK OLFI8_RAT AK--LCPSGDNFSLKGS-----------AMAMMYTVVTPMLNPFIYSLRNRDMKQA-LIR OR6J1_HUMAN TY--VTPSQKEYLEINK-----------IPLVLSSVVTPFLNPFIYTLRNDTVQGV-LRD OL287_RAT AY--VRTSVESSLDLTK-----------AITVLNTIVTPVLNPFIYTLRNKDVKEA-LRR O11A1_HUMAN AR--VAPSAVHSQLLSK-----------VFSLLYTVVTPLFNPVIYTMRNKEVHQA-LRK O11H6_HUMAN TL--VSPTSGNPAGMQK-----------IITLVYTAMTPFLNPLIYSLRNKDMKDA-LKR O10K1_HUMAN IR--LRPKTNYTSSQDT-----------LISVSYTILTPLFNPMIYSLRNKEFKSA-LRR OR2K1_HUMAN IF--LKPSSSNAQKIDK-----------IISLLYGVLTPMLNPIIYSLRNKEVKDA-MKK O13C3_HUMAN MF--AKPKSQDLIGEEKLQALDK-----LISLFYGVVTPMLNPILYSLRNKDVKAA-VKY OR2F1_HUMAN IQ--IQPHSSPSVLQEK-----------LFSVFYAILTPMLNPMIYSLRNKEVKGA-WQK O2A12_HUMAN LH--MAPKSSHSQERRK-----------ILSLFYSLFNPILNPLIYSLRNAEVKGA-LKR OR9G1_HUMAN LF--ALPRSSYSFDMDK-----------IVSTFYTVVFPMLNLMIYSLRNKDVKEA-LKK OR9G5_HUMAN LF--ALPRSSYSFDMDK-----------IVSTFYTVVFPMLNLMIYSLRNKDVKEA-LKK OLF2_CANFA CY--FRPSSSYSLDQDK-----------IISLFYSLVIPMLNPLIYSLRNKDVKEA-LKK O1044_MOUSE TF--LQPSSNHSLDTDK-----------MASVFYTVIIPMLNPLIYSLRNKEVKDA-LKK OR8D2_HUMAN AF--FKPPSSTTMEKEK-----------VSSVFYITIIPMLNPLIYSLRNKDVKNA-LKK OL502_MOUSE IY--VMPKSSYSTDQNK-----------VVSVFYMVVVPMLNPLIYSLRNKEIKGA-LKR OR3A3_PANTR AH--MRLGSVESSDKDK-----------GVGVFMTVINPMLNPLIYSLRNTDVQGA-LCQ OR3A1_HUMAN IH--MRLGSTKLSDKDK-----------AVGIFNTVINPMLNPIIYSFRNPDVQSA-IWR O10AD_HUMAN VH--MNPHSTHGPDKDK-----------PFSLLYTIITPMCNPIIYSFRNKEIKEA-MVR O56A4_HUMAN SF-------VITNLARKRIPPDV-PI--LLNILHHLIPPALNPIVYGVRTKEIKQG-IQN O51A4_HUMAN TLVVHRFARHVSPLINV-----------LMANVLLLVPPLTNPIVYCVKTKQIRVRVVAK OPSD_BOVIN GQ--AGVAFYIFTHQGS----DFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTT 000000000000000000000000000000000000000000000 OR4C6_HUMAN LWMKWEALAGK---------------------------------- OR4N4_HUMAN LLS-RHVVCQVDFIIRN---------------------------- O12D3_HUMAN IFG-RKLFKDWQQHH------------------------------ O12D2_HUMAN VIR-RL--------------------------------------- O1078_RAT TLCEEVIRSPPSLLHFFLVLCHLPCFIFCY--------------- OR7AH_HUMAN SFRG-KQ-------------------------------------- OR1G1_PANTR LIW-VRKIHSP---------------------------------- OLFI8_RAT VTCSKKISLPW---------------------------------- OR6J1_HUMAN VWVRVRGVFEKRMRAVLRSRLSSNKDHQGRACSSPPCVYSVKLQC OL287_RAT TVKGK---------------------------------------- O11A1_HUMAN ILC-IKQTETLD--------------------------------- O11H6_HUMAN VLGLTVSQN------------------------------------ O10K1_HUMAN TIGQTFYPLS----------------------------------- OR2K1_HUMAN LLG-KITLHQTHEHL------------------------------ O13C3_HUMAN LLN-KKPIH------------------------------------ OR2F1_HUMAN LLWKFSGLTSKLAT------------------------------- O2A12_HUMAN VLW-KQRSM------------------------------------ OR9G1_HUMAN LLP------------------------------------------ OR9G5_HUMAN LLP------------------------------------------ OLF2_CANFA LKN-KKWFH------------------------------------ O1044_MOUSE LIA-SKNQMLSS--------------------------------- OR8D2_HUMAN MTRG-RQSS------------------------------------ OL502_MOUSE QLA-KNTFS------------------------------------ OR3A3_PANTR LLV-VKRSLT----------------------------------- OR3A1_HUMAN MLT-GRRSLA----------------------------------- O10AD_HUMAN ALG-RTRLAQPQSV------------------------------- O56A4_HUMAN LLKRL---------------------------------------- O51A4_HUMAN LCQRKI--------------------------------------- OPSD_BOVIN LCCGKNPLGDDEASTTVSKTETSQVAPA----------------- b. 00000000000000000000000000000000000000000000000000000000000 Ddis.Lip VTYAYNSFKRYIPEGVHAVKPFYPEKYVGKWYEIARLYTYEKD--------LDKITAEY Atha.OML ---------MTEKKEMEVVKGLNVERYMGRWYEIASFPSRQPKN-------GVDTRATY Hsap.ApoD -----QAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTENG---------RCIQANY Dmel.NLaz ----AQVPFPGKCPDVKLLDTFDAEAYMGVWYEYAAYPFAEIG--------KKCIYANY Dmel.GLaz --AGTDAYGFGRCPNYPSMPKFNMSRVLGHWYEVERSFYLEIASGCTTFQFEPYNKGEQ Dmel.Karl YQTRRRSGPSNRCPKVGAIKNFDLERMMGCWHVVQYYASTELP---------EYACMRS Same.Laz ------AQETMGCADRSAINDFNATLYMGKWYEYAKMGSMYEE--------GGVCVTAE Msex.IcyA ----GDIFYPGYCPEVKPVDDFDLSAFAGAWHEIAKLPLEENE--------GKCTVAEY Rnor.RBP -------ERDCRVSSFRVKENFDKARFSGLWYAIAKKDPELFL--------QDNIIAEF Btau.BLB ------------LIVTQTMKGLDIQKVAGTWYSLAMAASDISL--------LDAQSAPL Hsap.Glyc ---------VPAMDIPQTKQDLELPKLAGTWHSMAMATNNISL--------MATLKAPL Meug.BL ------------VENIRSKNDLGVEKFVGSWYLREAAKT-------------MFSIPLF Rnor.PGDS ------------QGHDTVQPNFQQDKFLGRWYSAGLASNSSW---------FREKKELL Hsap.NGAL QDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAI----------LREDKDPQ Mmus.A1mg -------DPASTLPDIQVQENFSESRIYGKWYNLAVGSTCWLS-------RIKDKMSVQ Hsap.C8GC QKPQRPRRPASPISTIQPKANFDAQQFAGTWLLVAVGSACFLQ---------EQGHRAE Rnor.ERBP ----------------AVVKDFDISKFLGFWYEIAFASKM------------TGLAHKE Ggal.QS21 -----------------AATVPDSSEVAGKWYIVALASNTS----------FLREKGKM Mmus.MUP1 ----------HAEEASSTGRNFNVEKINGEWHTIILASDKEKI---------EDNGNFR Sscr.VEG -------------AQEFPAVGQPLQDLLGRWYLKAMTSDPIP----------GKKPESV Maur.Aphr ---------------------QDFAELQGKWYTIVIAADNEKI---------EEGGPLR Hsap.OBP2 ------------------SFTLEEEDITGTWYVKAMVVDKFPE---------DRRPRKV Hsap.a1G2 ------QIPLCANLVPVPITNATLDRITGKWFYIASAFRNEYN-------KSVQEIQAT 00000000000000000000000000000000000000000000222222220000000 Ddis.Lip SINKDGSITVVNSGYNYKKKKRE-----AKGIAYFVNGSD----EGMLKVSFFG----- Atha.OML TLNPDGTIHVLNETWS-NGKRGF-----EGSAYKADPKSDEAKLKVKFYVPPFLPI--- Hsap.ApoD SLMENGKIKVLNQELRADGTVNQ-----EGEATPVNLTEP---AKLEVKFSWFMP---- Dmel.NLaz SLIDNSTVSVVNAAINRFTGQPS-----VTGQAKVLGPGQ-----LAVAFYPTQP---L Dmel.GLaz SKFSNFKLAVAIKNINRITGNPNVNIGYAPENSRSSIMDF--KFTTRFPFPDVIARLLP Dmel.Karl HFSFSKEDQHITMNFSYIFAEDPL--RKLVGNITWMIPKFQEPGHWQHTEDIYEG---- Same.Laz YSMSSNNITVVNSMKDNTTHEVNT---TTGWAEFASEL-HT-DGKLSVHFPNSPSVG-- Msex.IcyA KYDGKKASVYNSFVINGVKEYME----GDLEIAPDAKLTK--QGKYVMTFKFGPR---V Rnor.RBP SVDEKGHMSATAKGRVRLLSNWE----VCADMVGTFTDTE-DPAKFKMKYWGVASFLQR Btau.BLB RVYVEELKPTPEGDLEILLQKWE----NGECAQKKIIAEKTKIPAVFKIDAL------- Hsap.Glyc RVHITSLLPTPEDNLEIVLHRWE----NNSCVEKKVLGEKTGNPKKFKINYTVA----- Meug.BL DMDIKEVNLTPEGNLELVLLEKA-----DRCVEKKLLLKKTQKPTEFEIYISSES---- Rnor.PGDS FMCQTVVAPSTEGGLNLTSTFLR----KNQCETKVMVLQPAGVPGQYTYNSPHWG---- Hsap.NGAL KMYATIYELKEDKSYNVTSVLFR----KKKCDYWIRTFVPGCQPGEFTLGNIKSYP-GL Mmus.A1mg TLVLQEGATETEISMTSTRWRRG----VCEEITGAYQKTD--IDGKFLYHKSKWN---- Hsap.C8GC ATTLHVAPQGTAMAVSTFRKLDG----ICWQVRQLYGDTG--VLGRFLLQARGAR---- Rnor.ERBP EKMGAMVVELKENLLALTTTYYS---DHCVLEKVTATEGDG-PAKFQVTRLSG------ Ggal.QS21 KMVMARISFLGEDELEVSYAAPS---KGCRKWETTF-KKTS--DDGELYYSEEA----- Mmus.MUP1 LFLEQIHVLENSLVLKFHTVRDE----ECSELSMVADKTEK--AGEYSVTYDG------ Sscr.VEG TPLILKALEGGDLEAQITFLIDG----QCQDVTLVLKKTN---QPFTFTAYDG------ Maur.Aphr FYFRHIDCYKNCSEMEITFYVIT----NNQCSKTTVIGYLK-GNGTYQTQFEG------ Hsap.OBP2 SPVKVTALGGGNLEATFTFMRED----RCIQKKILMRKTEE--PGKYSAYGGR-----K Hsap.a1G2 FFYFTPNKTEDTIFLREYQTRQN----QCFYNSSYLNVQRE--NGTVSRYEGG-----R 00002222222222222222222000000022222222220000000000000000000 Ddis.Lip ---PFYSGYNVIAIDPDYKYAIAGQ----SFDYMWILSKEPTIPEKIKNSYLELAKSVG Atha.OML --IPVTGDYWVLYIDPDYQHAIGQP----SRSYLWILSRTAQMEEETYKQLVEKAVEEG Hsap.ApoD -SAPYWILATDYENYAVYSCTCIIQ--LFHVDFAWILARNPNLPPETVDSLKNILTSNN Dmel.NLaz TKANYLVLGTDYESYAVYSCTSVTP--LANFKIVWILTRQREPSAEAVDAARKILEDND Dmel.GLaz GSGKYQVLYTDYENFALWSCGSIGS--LGHSDQIWILGRDRDFEVDIRSKVYDVLKRLS Dmel.Karl -IYNTYVLDTDYDTWGVMHCAEKKK--QPRYLSALLLSRKTSLADNEISFLRGKLPQD- Same.Laz ---NYWILSTDYDNYSVWSCVKRP-DSAASTEISWILLRSRNSSNMTLERVEDELKNLQ Msex.IcyA VVQVPWVLATDYKNYANYNCNYHP-DKKAHSIHAWVLSRNKVLEGNTKEVVDNVLKTFS Rnor.RBP GNDDHWIIDTDYDTFAQYSCRLQNLDGTCADSYSFVFSRDPNGLTPETRRLVRQRQEEL Btau.BLB NENKVLVLDTDYKKYLFCMENSAE---PEQSLACQCLVRTPEVDDEALEKFDKALKALP Hsap.Glyc --NEATLLDTDYDNFLLCLQDTTTP---IQSMMCQYLARVLVEDDEIMQGFIRAFRPLP Meug.BL ASYTFSVMETDYDSYFFCLYNISDR----EKMACAHYVRRIE-ENKGMNEFKKILRTLA Rnor.PGDS SFHSLSVVETDYDEYALFSKGTKGP--GQDFRMATLYSRAQLLKEELKEKFITFSKDQG Hsap.NGAL TSYLVRVVSTNYNQHAVFFKKVSQN---REYFKITLYGRTKELTSELKENFIRFSKSLG Mmus.A1mg ITLESYVVHTNYDEYAFLTKKSSHH--HGLTITAKLYGREPQLRDSLLQEFKDVALNVG Hsap.C8GC GAVHVVVAETDYQSFALYLERAG-------QLSVKLYARSLPVSDSVLSGFEQRVQEAH Rnor.ERBP -KKEVVVEATDYLTYAIDITSLVAG---AVHRTMKLYSRSLDDNGEALYNFRKITSDHG Ggal.QS21 -EKTVEVLDTDYKSYAIFATRVKDG---RTLHMMRLYSRSREVSPTAMAIFRKLARERN Mmus.MUP1 -FNTFTIPKTDYDNFLAHLINEKDG---ETFQLMGLYGREPDLSSDIKERFAQLCEKHG Sscr.VEG KRVVYILPSKVKDHYIYCEGELDG----QEVRMAKLVGRDPENNPEALEEFKEVARAKG Maur.Aphr -NNIFQPLYITSDKIFTNKNMDRAG---QETNMIVVAGKGNALTPEENEILVQFAHEKK Hsap.OBP2 LIYLQELPGTDDYVFYKDQRRGGL------RYMGKLVGRNPNTNNLEALEEFKKLVQHK Hsap.a1G2 EHVAHLLFLRDTKTLMGSYLDDEKN-----WGLSFYADKPETTKEQLGEFYEALDCLCI 0000000000000000000000000000000000000 Ddis.Lip YDITK-LIWSKQNENEN-------------------- Atha.OML YDISK-LHKTPQSDTPPESNTAPEDSKGVWWFKSLFG Hsap.ApoD IDVKK-MTVTDQVNCPKLS------------------ Dmel.NLaz VSQAF-LIDTVQKNCPRLDGNGTGLAGEDGLDVDDFV Dmel.GLaz LDPER-LIISKNKQCPEAL------------------ Dmel.Karl IDTSF-MFNIGQESCDNLMESSRDDPLAYVVNGRQRA Same.Laz LDLNKYKTEQSAKYCA--------------------- Msex.IcyA HLIDASFMSNEFSEAACQYSTTYSLTGPDRH------ Rnor.RBP CLERQ-RWIEHNGYCQSRPSRNSL------------- Btau.BLB MHIRLSNPTQLEEQCHI-------------------- Hsap.Glyc RHLWY-DLKQMEEPCRF-------------------- Meug.BL MPYTV-IEVRTRDMCHV-------------------- Rnor.PGDS LTEED-VFLPQPDKCIQE------------------- Hsap.NGAL LPENH-VFPVPIDQCIDG------------------- Mmus.A1mg ISENS-IFMPDRGECVPGDREVEPTSIAR-------- Hsap.C8GC LTEDQ-FYFPKYGFCEAADQFHVLDEVRR-------- Rnor.ERBP FSETD-YILKHDLTCVKVLQSAAESRP---------- Ggal.QS21 YTDEM-AVLPSQEECSVDEV----------------- Mmus.MUP1 ILREN-IDLSNANRCLQARE----------------- Sscr.VEG L-NPD-VRPQQSETCSPGGN----------------- Maur.Aphr IPVEN-LNILATDTCPE-------------------- Hsap.OBP2 GLSEEDFTPLQTGSCVLEH------------------ Hsap.a1G2 PRSDV-YTDWKKDKCEPLEKQHEKERKQEEGES----