25 1219 1_CG15585 ---------- ---------- ------MLL- ---------- ---------- 2_CG1148 ---------- ---------- ---------- ---------- ---------- 3_CG1150 ---------- ---------- --------M- ---------- ---------- 4_CG10303 ---------- ---------- ------MPR- ---------- ---------- 5_CG15590 ---------- ---------- ---------- ---------- ---------- 6_CG1151 MNTPVISVVP KEFSLRNHQS TNPATSMKF- ---------- ---------- 7_CG1153 ---------- ---------- ---------- ---------- ---------- 8_CG15591 ---------- ---------- ---------- ---------- ---------- 9_CG15592 ---------- ---------- ---------- ---------- ---------- 11_CG15596 ---------- ---------- ---------- ---------- ---------- 12_CG1154 ---------- ---------- ------MIF- ---------- ---------- 13_CG15595 ---------- ---------- --------M- ---------- ---------- 14_CG1155 ---------- ---------- ---------- ---------- ---------- 15_CG1157 ---------- ---------- ---------- ---------- ---------- 16_CG31561 ---------- ---------- ---------- ---------- ---------- 18_CG1169 ---------- ---------- ---------- ---------- ---------- 19_CG15189 ---------- ---------- ---------- ---------- ---------- 20_CG15188 ---------- ---------- ------M--- ---------- ---------- 21_CG14925 ---------- ---------- ------M--- ---------- ---------- 22_CG8644 ---------- ---------- ---------- ---------- ---------- 23_CG15538 ---------- ---------- ------M--- ---------- ---------- 24_CG15589 -------MKM GSQYIDG--- ----AKLKA- ---------- ---------- a10_CG1559 ---------- ---------- ---------- ---------- ---------- b10_CG1559 ---------- ---------- ---------- ---------- ---------- 17_CG15598 -------MPN TYSAL----- PH--NRSSGE SQQQWTSSSR NRTCHPVSMA --------CR ----VVLAL- --LLL--VLL HY-----CQA KDEGETTQRG ---------- MAMRALIFL- --ALA----- -------TLV AGEGLRLPDQ --------QT FKVCALLAF- --CFV-LVSA R--------- ---------- --------HL VASCLLLAL- --G-L--NMS LA-----AIH KRSGANS--- ---------- ----MFRTF- PLLCL--LFL T--------- ---------- --------FV ATACILLLA- AGISADPVKA A--------- ---------- --------MA SHKVTFGVL- --CLV--ALS AA-------- ---------- ---------- ----MIKYV- --WHV--AAL MIVFCWLSSA RSASYQH--- ---------- --MFKFVCL- --FAL-IAST A--------- ---------- ---------- MESRLGLLI- --ALL-LAAF QA-------- ---------- --------KQ WPWQ--ALI- --SLLSVLFL A--------- ---------- --------FK SSISIVVLH- --LLL--LVS FG-----GAY TL-------- ---------- --MKVFAIA- CVTLL-AASC V--------- ---------- ---------- --MCAKFVC- --VVL--LAS LV-----C-G SMALPSQDNT ---------- --MLLTKTV- KYLFY-LALF A--------- ---------- ---------- ----MKSTA- ACLIV--ALA AL-----STA HSA------- ---------- -------MAK LLLVIVGVAA L--------- ---------- --------AF R---STSLL- --AFG--CAL LL-----VAS TSVSGAAIEN ---------- --KRLEWLL- --LLA--LVA SV-----STA VTPRRRRHSA ---------- ---MSDLVR- --FLL--LSV LC-----SSL ALAQASSSDG --------R- --VPSVLVT- --FLL--GVI LV-----DRY AAGEDLADK- --------NS HRKRRCSPL- --LYG--IIL LC-----KVA MIPAAVPE-S ---------- -----MSPL- DIVLL--LVS F------HQV IGSDFSAMSL ---------- ---------- ---------- ---------- ---------- RSTSGHLIFL L--LICLIN- --SAA----K AD-----GTA RN----GRLG AVLVSLT--- ---------- ---------- ---------- ---------- QSSNNIQQVY APQPPAQQ-- ---------- ----IQQPQQ QQQFPQAQQP ---------- ---------- ---------- ---------- ---------- LGVD------ PE-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---QNPNSLS SAPRPQVQN- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- A--------- ---------- ---------- ---------- ---------- VESA----TT SS-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ELDAGALYSQ PLTTMAGQPR NDD-TFRPIL PIDISPEFIS RNVFTKSGQY E--------- ---------- ---------- ---------- ---------- ---------L LASSVEQE-- --GELLLRNF QDPH---RME GWQAVD---- RHLSTTPLSH PTVESQPTEE QEMFTESPTE SPEDVELATT ---TELPPEE ---------- ---------- ---------- ---------E NMAKSAGSQL GVGEERGRSS LLSIFGL--- ---------- ---------- ---------- ---------- ---------- ---------- ---GSKRRDG TVTISESERK ---------- ---------- ---------- ---------G KPA-ANPAVS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------LPAE ETRGHARNAI ---------- ---------- ---------- ---------- SNPGMGSTGL ---------- ---------- ---------- ---------- ----AATSEA ---------- ---------- ---------- ---WAMEA-- PSNYNQNSTE ---------- ---------- ----SS--CG AATEQL---- GSPPGPSPSQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FAAPSVQDNQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------FM CKYATAASVQ PTEVP-AVAP ---------- ---------- ---------- ---------- PTEGQV--AP ---------- ---------- ---------- ---------V AAGQAAGGST ---------- ---------- ---------- ---------- --V---TPRI ---------- ---------- ---------- ---------- PGDWGTAWGL ---------- ---------- ---------- ---------N QETST---VS ---------- ---------- ---------- ---------- --------SW RVFQPAESES DLRLAVAMRR RNFKHPSDS- ---------P RKQESESSAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DWQPLINA-- ---------- --TKF----- ---------P T----RKPMD -V--QADPFI SRNQKQC--- ---------- ------FET- RSLVSCIKYK --GNDNDPFL ARTNSNCL-- ---------- --------G- GDLSECFKTQ -N--IEDFLL AKLKQNCR-- ---------- ------QED- --DRACKMVK -V--ENTDLL DKLSWKC--- ---------- ---------- ANNASCLYGV ---------- AVRSENC--- ---------- ------DQDA GATLYCRGER -------EEQ PGAFAQCL-- ---------- ------ESD- --SISCLQLT -G--GENDIM DSIYSDCL-- ---------- ------RKD- --SVSCVKYK -W--KDMSMV YRIYQQCS-- ---------- ------GDN- --MSVCLKVK -D--SLLTSA LKMVKDCG-- ---------- ------ERS- --MVLCMKER -S--GLLRTV RHIYGQC--- ---------- ------AYS- EDVFWCCKIQ -S--AGARTL LRVYDECT-- ---------- ------RAE- AGFVPCLKKK ---------- ---------- ---------- ---------- ---------- VEGDNTLGRA ARYLGAC--- ---------- ------LES- DDMATCLAVK ---------- ---------- ---------- ---------- -------ERD ETIRIPQRA- ESLLSGC--- ---------- ------EAS- SFSWMCLKIE -Q--SATQLA LDMYHGC--- ---------- ------L-K- DLSVSCVRPK E---KMQRLI AEEQNKC--- ---------- ------ASG- QDSMACIKER -H--SSDELI STIVDKCF-- ---------- ------H--- ANAMHCLKEK -G--PEMALV RRVYDDC--- ---------- ------QDK- NDFIGCLKQK -Q--EAARGL A-SSYEPEDK QALRKNSHIF MGIYKNYKS- TYLGNKTTSE -I--SQMKKL RSDLRDCYQS GIHQS----- ---------- --LWSCFRSR -A--FK---- ---------- ------N--- ---QTITSI- DAELKGLEDL ---------- ---FKQCVRG ---------- ------SQK- PKIGECLGRS ---------- ---------- ---------- ---------- -----CLGSE -K--MAPSDS LLLRLARR-- --FASGNELW DGLVRDCYL- KPDVSCFQKN TS-KLIWKLA ---TNSMGFF PSEYGRDLAG D--------- ---RGRWLRL AL-NTFDEIF F--------- ------KDQY K--------- ---LSDFARV MS-IVMNHLY --L------- ------NTRI D--------- ---LGDRFKV AN-GLMASYR R--------- ------GETL K--------- -LGLFDLVKL ALRNVLRNLN --RS------ ------DKPL V--------- ---VIRGLEI LF-RKAKSVF ---D------ ------NPQI E--------- ---LFGGVSL LF-SFVDKVL --GA------ ------RDQF A--------- ---LTEGVTV LL-TGLEKAF --RS------ ------AKSL S--------- ---LMEGIQF AL-HYFDAE- ---------- ------NGDV R--------- ---LTEGIAL GV-RLLGRAL --K------- ------VPQL G--------- ---IVDGVSL AI-SFIDRLA --P------- ------IDAI N--------- ---VAEGIKL ---------- ---------- ------PPVV Q--------- ---MGGAIVA GI-TALNRAA --R------- ------SNNI E--------- ---LASGVTF LV-NMLNRLD ---S------ ------EESV A--------- ---LFGGLRI FV-KIMEKLA ---E------ ------QEEL N--------- ---VLPGISV AL-QWFNSAL ---R------ ------QPEV R--------- ---ITERLSI AM-RFVDNVM ---S------ ------KDSF Q--------- ---VSN-LEV VL-TYLDTVA --NV------ ------EEEV S--------- -GRA----LG AL-HALSRAL ---D------ ------QDSI K--------- ---IVDGLAL YKKRLRDRVS A--------- -PQMAENETP EMVEPDQEDQ RDSLAQEIRQ SL-HIFEGIM ---S------ ------SPEI S--------- ---IYDGVRL LV-DYVEQFF S--------- ------NGRY E--------- ---PTPGLVL AL-NFIQKLD ---E------ ------SDNV K--------- ---FVEDFVT SE-QLLDGAT --RD------ ------NSTW Q--------- ---ITDYLSI VF-SYLDNVL DV-------- -------QDV N--------- ---VTQRLKF VQL------- ---------- ---------- ---------- ---------G VRLPE----- -----TQQR- -SLLQEPF-- ---------- ---------- TENGN----- -----ISMV- ---------- ---------- --------PD PELDA----- -----SRKHK W----GTGRG ---------- ---------- VPLQN----- -----NSIS- ---------- ---------- ---------- VKSNE----- -----GRQG- ---------- ---------- -------KSL VRSPD----- -----APQQ- ---------- ---------- ---------- VSSGG----- -----ESEE- ---------- ---------- ---TKRAPIS VKTDE----- -----IPVG- ---------- ---------- ---------- VRR------- -----ESFT- ---------- -------QDT RSGRSSLLES VRLET----- -----APRP- ---------- ---------- ------PATS AVEQD----- -----AEQE- -AAAEER--- ---------- ---------- QRDPA----- -----SPVS- ---------- ---------- ---RTGKSMS DRSES----- -----GRSF- -GASKAV--- ---------- ---------- VKDEN----- -----A---- -TELKTS--- ---------- ---------- VRTAE----- -----KVE-- ---------- ---------- ---------- RSNGE----- -----KTTPI NEARAS---- ---------- ---------- DDV------- ---------- ---------- ---------- ---------- EKQNQ----- ---------- ---SETESIL G--------- ---------- DAQAE----- -----ALME- -TQTESPNYD DSESLAAKKR RKRKRKDRNK VAA------- ---------- ---------- ---------- ----P----N ALQQN----- -----HSHP- -QSYTG---- ---------- ------KR-- VKSET----- -----AAVR- ---------- SLSNVLDTDP VDF------- EPK------- --------V- -GISKPE--- ---------- ---------- FKNQVDYQVD KEKEEH---- ------SEAR AA-------- SAETPIEE-- EPADEVVVFN DAKSLEGDSE LTM------- ----ILKFL- ----KRAMET ---------- -------EYS EEPRGDDDEW --NQLLKYG- ----LRRAER DPEVNQLLSR SM-----GSD EET------- ----FALLM- ----ANKLWK ---------- ---------- ---------- ---------- ----LSGFMD ---------- ---------- ---------D EEPDQEQGL- ----LDSLSF DNSLAVEAAP TV-----EAR TAE------- ----MGNYF- ----MDNAKS ------EAAR SI------SG DES------- ----FESLA- ----LNRISS EKDIEAVLPR SV-----DAK EQV------- ----LNNMI- ----LKRVGN RSLNEMQLPE EV-----EAR EAE------- ----VDSLL- ----VERVAR Q-LSNRDLE- -------HLS GKS------- ----LDALL- ----LERFLN ENELESSLPR SG-----SDR DAK------- ----LTNML- ----IERLSY ---------- --------QR VERHWLSMAE --TQLHSLIT DDLSTEEVNN EQDVYAELPQ NA-----DER TGR------- ----LVDLA- ----VSSAAD ---------- ---------- ---------- ------ESF- ----EDRAER --ELMAEVAR SYP----SDP STR------- ----LNGYI- ----VAKLEN ---------- ---------- -------SRS --MNPEERL- ----FDDIDS ---------- ---------- ---------- ----SADGF- ----LDAIEN ---------- ---------- ---------- ----IDKVI- ----VDRLGR ---------- -------SLT DARQFG--NL --SPIDRAL- ----LSKADK RKDE------ -V-------- -----ESETD --QPDPAPE- ----DETIQR S---TD-NAT RPDDERKDLK HLT------- ----WFDQL- ----AVSLAK ---------- ---------- ---------- ----TTRSI- ----LE---- ---------- ---------- ---------- ------RGI- ----LENAGA ---------- -------TRR MD-------- ------MGL- ----PGKLLE ---------- ---------- ---------- ----VTSAL- ----YGKSIK FGRNH-GLQL RLN---SEGG ARVMEES--- ---------- ---------- FIKST-ALEV EWP---E-EL TEAGRYEARF IGNDIDGELD LIDDG----- FIRSR-SLRY KFS---E-NT DFVI----NS DPEGSLNLGV SVRPLEALQ- FVTEN-AIRV PVG---P-MV FSVQRAEDDS DYIEVALLKK TSSST----- YLRTH-EINV KLA---D-LL EDES---QVS ---------- ---------- FFAER-SLNF NFA------- ----NAARSV ARAIPDDIKA DLRELVV--- FLNSH-TIKV ELK---G-AD IVQA--VSST GR-------- --------AL FLQDH-TLQV KFDN----EA NSV------- ---------- ---------- FFGTH-TLQF KVP---K--- ----DSIQDM QRALE----- ---------- FVHSH-QLQV NLP-----RL LRFGE--RNV QDWLLHVVGY FMPASE---- FFNGH-SLQV SFP---K--- ----LTSDEI GRGLE----- ---------- ML-------- ---------- ---------- ---------- ---------- FLSTH-NLEF KLP---A--- ----ETTQQV ARALD----- ---------- YLETH-ELNL SFS---G-DE QDENSENEYT GRAMD----- ---------- LLRTR-FLRF RLL---D-DK SLV------- ---------- ---------- YLGSH-SLRI QAP---E-YF RTSE-ARSLV PDFLMSNPLT QGGLVPLAAA YIRGH-DVSM DLP---L-AD AKVTVSARNL VNNQLSLNLQ LNGDDGDEGT ILNTN-EMRL QLP---Q-TF FAGSVVTYRS DRG---FDLE -LPKDEGRA- LMRTH-TLKI DMDVGGGEDS ----VGR--- ---------- ---------- YNVGP-GLNV SLD--MS-ND IVHVKLDGEN LKEIIGARWL TLDNSE---- GLTTH-TLQV NLG---K-LT ERYLSSDP-- -----VG--- ---------- ---------- ---------- ---------- ---------- ---------- VMGQR-SMEW HMD------- ---------- ---------- --------GL LVQGR-ALRL QLP---R-QL TISNAIDDFG SELGLD---- ---------- FAMTHDLEVD LPE------- ---------- ---------- --VM--FNGA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EDASESLF-- -----GSNDP NAPE------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- S--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- N--------- ---------- ---------- ---------- ---------- DV-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------DTN VEL------- ---------N YPGLMFKIGP TADANSVAEF VLDGA---AQ GER------- ---------Q ---------- ---------- ---------- ---------- ---------- TFRISPRA-I EGN-----GI IAKLELIPKQ VVKARLAGAI IQKKIQKFLR --------E- ----AR---- ---------- ---------- ---------- --------QR AGHFSR---- ---------- ---------- ---------- --------E- ----GR---- ---------- ---------- ---------- ---------- ----GRLQVN GGGLLGGGGG LGGNGGGGGG LLGGGGGDNG --------E- ----AR---- ---------- ---------- ---------- --------E- ----SR---- ---------- ---------- ---------- --------E- ----SR---- ---------- ---------- ---------- --------E- ----GR---- ---------- ---------- ---------- --------E- ----SR---- ---------- ---------- ---------- --------E- ----GR---- ---------- ---------- ---------- --------E- ----GR---- ---------- ---------- ---------- --------ET WSTEGR---- ---------- ---------- ---------- --------E- ----GR---- ---------- ---------- ---------- --------E- ----SR---- ---------- ---------- ---------- --------E- ----GR---- ---------- ---------- ---------- --------E- ----GR---- ---------- ---------- ---------- --------E- ----AR---- ---------- ---------- ---------- --------E- ----KK---- ---------- ---------- ---N------ ---------- ----EH---- ---------- ---------- ---------- --------E- ----GRG--- ---------- ---------- ---------- --------S- ----AR---- ---------- ---------- ---V------ VPRAFESARL LFFSGL---- ---------- ---------- ---------- FGFE-DPST- ----GR---- ---------- ---------- ---------- --------Q- ----GR---- ---------- ---------- ---------- SKLVLSFLAL LLIIKI---- ---------- ---------- ---------- ---------- --------LK -RKKKK---W LI----ILPL VILMKIA--H ---------- ---------K -KL-KK---- -M----IIPL LLVLKIF-KL ---------- ---------G -KM--K---- -N----MGPL LMMMAAK--- GGGGLLGG-- RRRHQH-QDK -KQ-FQ---- -M----FIPM YLAATTF--- ---------- ---------- -KK-DK---- -G----QGML LAMALMF--- ---------- ------TRKK -KL-LK---- -K----FLPI LLGVGAK--- ---------- ------GKKK -KA-AK---- -I----LGPI LALVALK--- ---------- ---------K -KKEKK---- -G----NGAM IMIPLLL--- ---------- ------GKKK -EK-KK---- -Y----LMPL LMLFKLK--- ---------- ---------K KKDDKK---- -Y----LGPF IAAVLLK--- ---------- ---------G -KM-KK---- -M----MGMM MMGMAMK--- ---------- GKH---KKQK -KL-MK---- -M----VYPL LAAVAVA--- ---------- ---------G -KI-KK---- -M----LGPV ALAIGAK--- ---------- --------SK -RM-KK---- -M----LLPL LLALKLK--- ---------- ----KHKFGK -KG------- -G----LEAL VAAGVMM--- ---------- ---------G -MI-RK---- -A----VLPF LLGLKLK--- -------GKK GNIFKKGKKH -RL-RK---- -L----AMPI LVLILLK--- ---------- ---------- --K-DK---- -L----FLPL LLLMKFK--- ---------- ---------G HKK-KKHKEG GH----IKYV VAALLTA--- ---------- ---------- ----KKYDMI TK----VLPL FILPFLI--- ---------- --------RR -HR-YN---- -M----IITM MFGVTAL--- ---------- ---------- ----KK---- -V----MWPI YMGLQVLKSV ---------- ---------V -LT-KQ---- -Y----LLPF LLGLKFN--- ---------- ---------K -KK-DK---- -D----KNMA MMGGMIM--- ---------- ---------- ----IK---- -IKLFWLLPI VIGVGAAKKL LK--MTLVSM LMG---VLGM NVL------- ---------- ---------- KL--LLFLPF ILGIAGLKK- ---------- ---------- ---------- -T--GMVGAL LLKGLFLLAG KAL------- ---------- ---------- -----GWTMV AAKAVGLLTL KAL------- ---------- ---------- -G--KMMAVM GLGGIAALAM KAL------- ---------- ---------- -I--AVLGVG SIFGLLFLAK KAL------- ---------- ---------- -A--AALLPL LLGAIALIAG KAL------- ---------- ---------- -G--GTIVPL AYGALAMLAG KAL------- ---------- ---------- -M--AALLPL AIGFLALISF KAL------- ---------- ---------- ----TAILKM AYHSIAIVAG KAL------- ---------- ---------- -M--MGMIPI AMGALYILAG KAL------- ---------- ---------- -K--VVLLPL ILKWLTALST SSF------- ---------- ---------- -L--FAVIPL VLGFLALLTF KAV------- ---------- ---------- -K--AVVVKI MFTIIKFISL KAL------- ---------- ---------- -K--GMLMAM GLGAIALMAG KAL------- ---------- ---------- -T--TVLVPL ALGLIALKTW KAM------- ---------- ---------- -A--ITVIPM AIGILKIKAF NAL------- ---------- ---------- -L--KVIMPI LLALIGLKAT KAL------- ---------- ---------- -M--GIAGPL GLKALAAIAG KAL------- ---------- ---------- -Q--SAIVPF LVTKLKLLLV KSI------- ---------- ---------- -G--AILVPM GFQMLSIVSG KAL------- ---------- ---------- LF--AMFLPT IISSVSRLIG KGITSGSAGS VPLFIRP--- ---------- -L--VALVPL IFAGICLLLK KSL------- ---------- ---------- -M--ATLAQM FLGKVILIAG SAF------- ---------- ---------- LLKFLLFLFP ALSHLFKLCS HYQQSYHAPA KYHHHHHLID HHHTVVPPWH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------IE-- ---------- PP-------- ----QELDF- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SGEHHSVPEI IYTHPPKGHP SAYLHGAPVH ESYGPGFEHF EGAWENSGPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RDNSMN FDDDSKFSLA DEGKTPAGYE YNAEASQQQA QYAQVNGNSV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGSD------ ---------- ---------- ------SRPA HTQHHPV--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NQATLSRY-- GGQQMMQDTY LSALQSIGAA SFKNSQSMSG SFSAGAGGGA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----YVPGQG HHP-PQNVP- GLTAAAQIAA QYDPSRNNQH PQQPPQQPNH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PGMTKKP-TP AVMNTFQSFQ KVPSSSLLLS N--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- A-VQEPQLSP EIAAQLKEAI RIQTEQRLIQ QQQKILEHQP FVQDGQPLYP ---------L VGGVGWLIHY LKYKTMCKIH P--------- ---------- ---------I LGLAAIVLPG L-----FAYF K--------- ------LCRP ---------I VSKIALLLAV I-----ISLK K--------- ------LL-S ---------I LSKIAFVVAA I-----VLIK K--------- ------LMDN ---------G VSLVALMMAG M-----LGLK T--------- ------AA-Q ---------V VSVIAFFLAL A-----AGAS S--------- ------GLGR ---------L IGKIALVLSA V-----IGLK K--------- ------LL-S ---------I VSKLALVLAS I-----IGIK K--------- ------LL-S ---------V IGKIALLLSG I-----IGLK K--------- ------LL-E ---------I VGKIALIISA I-----IGLK K--------- ------LV-G ---------I ISKIALLLAG I-----IGLK K--------- ------LM-S ---------V MGKIALVTSG I-----LALK W--------- ------ILSG ---------I VAKLAFFLAI L-----VGGS R--------- ------LL-G ---------A ISFLALILAG A-----TFFK D--------- ------LL-A ---------M TALMALTLSG V-----LGLK S--------- ------LA-G ---------T LGLLSLVLSG A-----LVIF K--------- ------IAKP ---------A LGFFSFIVSV G-----LAIF Q--------- ------LCKK ---------I LSKIAIKLVL G-----FLIY N--------- ------LI-Q ---------V ISKVALTIAG I-----IALK K--------- ------LFSH ---------L VGKLAIFLLI I-----SAIK N--------- ---------- ---------L LAKMALLLAS I-----NGLK R--------- ------VA-- --YDPFYSPL LSRLDSVFAQ L--------- -KLNPENEAC REKLICLMYA ---------F LVKLAIYVSS F-----LGLG G--------- ------IVGG ---------I MAKIALVISL L-----GSLK K--------- ------GS-T LNYDPFYSPI LLKIDKIIEQ L--------- -GVKN--DLC KERIVCSMYK ---------- ---------- ---------- ---------- ---------- PGGVGGA-FG GGLSGLFGGK NT-------- ---------- ---------- ---SK----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---HG----- ---------- -----GESSH SISYVTGEGH HHKRRRRSSG IGGSGG-GGG LLGGLGGLFG GKNAGGSSA- ---------- ---------- ---QE----- ---------- -----KHVT- ---------- ---------- ---GGGG-G- ---------- -----KESS- ---------- ---------- ---SK----- ---------- ------KEN- ---------- ---------- ---HDGG--- ---------- -----EKTT- ---------- ---------- ---GKSS-GG SSGWSS---- ---------- ---------- ---------- GHAHDRL-E- ---------- ---------- ---------- ---------- ---GFGN-KF GG---NSFAG AYNSNAWSA- ---------- ---------- ---KKK---- ---------- -----EHIT- ---------- ----TAYITG ---GGG---- ---------- -----KSTT- ---------- ---------- ---------- ---------- -----KIVN- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---KLG---G MK--MNMVPM PAPV------ ---------- ---------- ---------- ---------- --DHSEETS- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NPAKYAP-YS NLVSAQLSRE LNELRKPTSD NPDILRF--- ---------- L--------- --------GG LGGGFG--GA SFGAANFGLG G---FSGHRP ---GHS---- ---------- ---------- ---------- ---------- DPATYSP-HS NFISAELSRD TSELEPVTHA NEAVRRF--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----KTIV-- ---------- ---------- ---------- -EVPSHH--- ---------- ---------- ---------- -------ASE KMMYQFP-EQ QQP------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----YEVV-- ---------- ---------- ---------- -AHPHHS-SS ----HEVV-- ---------- ---------- ---------- ---------- ----YEVV-- ---------- ---------- ---------- -AHPHYE--- ----YEIV-- ---------- ---------- ---------- -KHPQVQ-QS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SPLNADIVHS D--------- ---------- ---------- ---------- ----YEIVAK P--------- ---------- ---IYTSSHS HSVTHEDGGH ----YEVVHY P--HHVDHVV PHHIEHVVPH HIEHVVPHHI ------E-HI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----FQVHA- GEHNRRNTYV IR-PVSKTSA AAGAGGVGVT AAGGSSS-V- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IGQFPGKT-- ---------- ---------- ---------- ---------- ---------G S--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---FPEYNPQ GVG------- ----AATYYH ---------- ---------- ---------- ---------- ---------- TPYMMP-YG- MDY-PLHGAE ISPEMYPSSL HHLAMAGGGQ LPGHPGHPGL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AST GGWSSGGGA- HSTSH--DSY ---------- ---------- -------GSG YSADAGASSA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- HTYSSS-HQG EYDT------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- -GGGGGGGGW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------PAS ---------- ---------- ---------- ---------- ---------- SHSPHFAA-G GGGGGTASG- ---------- ---------- ---------- VPHHID-HHL EHHI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PAS-EYGV-P STT----ASS Y-DPS-SWE- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------GGG SGTEHVVVHS ---------- ---------- ---------- ---------- ---------- ---------- -HLVQTHSHV YESDPSDYSQ FVGSGSYSNS YSPYSSGSGA HHEHFEGGHG --GAPGPY-Y RQEPSFAKPY TDYYSKSYQ- --GQQVQGQQ ------DSYS SGWSRAFDGF VEGLVDVPAD ILAKEVQHQQ E-Q------- ESLSAESHLH SAQVSSDGSN NTQVLAALGG LGGLGHKIKR EDSWMAKTTP ---------- ---------- ---------- ---------- ---------- SSAGWSSGGS SGWDTHGAYS SPV------- ---------- ---------- SY---GSSGH GGWGR----S ID-------- ---------- ---------- ----VSSGGH SGWGR----- ---------- ---------- ---------- --------HE HSYGR----S LPSDDSQ--- ---------- ---------- ---GGHD--G GSYHR----S IDDEMM---- ---------- ---------- SS-GGGGGGG GGWDRRSLTE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AGWSSGASSS YPYARSISED GSD------- ---------- ---------- ---------- --WSRNGQAG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------D HHVDLPVEHI EHLEHPSPAW D-PHAWARSS ---------- ---------- --IAHDHHHT A-HITAHGPW DGRTFSSV-- PM------SG GPYAR-WD-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---GNKMVQS YEV-PSYWAG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SHESG----- --WHR----S MP-------- ---------- ----THD-TY ---------- ---------- ---------- ---------- ---------- PHELGGNSYS KDWATSKAYN A-HNYLDTIS KRIQ------ ---------- VGGNSVSFGD ---PQEAAYN GYYGRNSGKD IVAEQQPQKS ---------- ---------- ---AQNMAYS G-QQPGKVAQ ---------- ---------- ARRPLIYNYV QPHM--PYYR S--------- ---------- ---------- ---------- ------LAYR G-WD------ ---------- ---------- ---------- ---AQTIAYQ G-YKQARR-- ---------- ---------- ---------- ---AQDLAYG A-QKPVQA-- ---------- ---------- ---------- ---ELDTAYS G-WKPAAKES AGSAKSL--- ---------- ---------- ---AQQLAYA A-YKQ----- ---------- ---------- ---------- ---MQDKAYQ A-WMPHVAAS PSPVAKGS-- ---------- ---------- ---AQELAYR A-HHQEQVAH AQSRPQ---- -LQHLHPKAA ---------- ------IIHS H--APLVKGL H---ASDLSS SGSSWMPIRQ ---------- ---AQQLAYA G-QQQQ---- ---------- ---------- ---------- ---AADLAYN H-YGLAQPF- ---------- ---------- ---------- ------FGYG G-YARSLKVD QSANKI---- ---------- QEPQD----- ---AQDLAYA GQK------- ---------- ---------- PAPVVEQ--P QKLGQALAYQ A-YA------ ---------- ---------- ---------- ---SQNLAYS S-YHPSSSSS YSSGSSSGSS GSSSSYS--- ---------- ------DPYR YYYEYHQQ-- ---------- ---------- EPSRRSELAA AASSAAAAYN G-YRVEGKPT TWIS------ ---------- ---------- ---NNGLHYG LYHVPGE--- HLGGY-YDRG DVSHPRNVPI ---------- ------FKYM RAAKDGQDGV DCDESFAKCK ELKD----LE ---------- ------TVFG KGQDEFHH-- -------QYD V-HE------ SQLDQ-VEEP PLGSHMEYYQ A-YQMEPLKR R--------- -LHQAAAYPD ---------- ------YRLI QAARDGQDQK DCQSLYPQCN MPAK------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -R-------- ---------- ---------- ---------- ---------- APQVTKS--- ---------- ---------- ---------- ---------- PFIPLVSKDP -----NLYKP FL-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----SSS-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PVAVAP---- ---------- ---------- ------TLDM GLK------- NPAMLSTYND INKLVQARK- ---------- ---------- ---------- ---------- -------TSP YRRSERKVRF EQPRMAETPG QAPPVNPKPP QPRPEATKST RGFI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- --------- ---------- -------LA TQDRFYDFEN QRRPSNK-- ---------- --------- ---------- ---------